SIMILAR PATTERNS OF AMINO ACIDS FOR 5ND7_B_TA1B601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		3 THR A 661
PRO A 651
ARG A 652
 None
 0.86A 5nd7B-1b0kA:
undetectable		 5nd7B-1b0kA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		3 THR L 418
PRO L 267
ARG L 337
 None
 0.53A 5nd7B-1cc1L:
undetectable		 5nd7B-1cc1L:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR

(Bos taurus) 		PF00996
(GDI) 		3 THR A 413
PRO A 389
ARG A 292
 None
 0.77A 5nd7B-1d5tA:
1.3		 5nd7B-1d5tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00116
(COX2)
PF06481
(COX_ARM) 		3 THR B 111
PRO B 119
ARG B 192
 None
 0.87A 5nd7B-1fftB:
undetectable		 5nd7B-1fftB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR B 125
PRO B 205
ARG B 206
 None
 0.82A 5nd7B-1fn4B:
undetectable		 5nd7B-1fn4B:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE

(Streptomyces
clavuligerus) 		PF00491
(Arginase) 		3 THR A 249
PRO A 163
ARG A 165
 None
 0.82A 5nd7B-1gq7A:
2.7		 5nd7B-1gq7A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv3 MANGANESE SUPEROXIDE
DISMUTASE

(Nostoc sp. PCC
7120) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 THR A 182
PRO A 173
ARG A 171
 None
 0.82A 5nd7B-1gv3A:
undetectable		 5nd7B-1gv3A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1a IG GAMMA-2A CHAIN C
REGION

(Rattus
norvegicus) 		PF07654
(C1-set) 		3 THR C 394
PRO C 346
ARG C 344
 None
 0.77A 5nd7B-1i1aC:
undetectable		 5nd7B-1i1aC:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iok CHAPERONIN 60

(Paracoccus
denitrificans) 		PF00118
(Cpn60_TCP1) 		3 THR A 124
PRO A 450
ARG A 452
 None
 0.54A 5nd7B-1iokA:
undetectable		 5nd7B-1iokA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		3 THR A 210
PRO A 315
ARG A 316
 None
 0.86A 5nd7B-1izeA:
undetectable		 5nd7B-1izeA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j8s PYELONEPHRITIC
ADHESIN

(Escherichia
coli) 		PF03627
(PapG_N) 		3 THR A  72
PRO A  26
ARG A  25
 None
 0.74A 5nd7B-1j8sA:
undetectable		 5nd7B-1j8sA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		3 THR A 502
PRO A 425
ARG A 423
 None
 0.79A 5nd7B-1jmyA:
2.3		 5nd7B-1jmyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxv CAMELID VHH DOMAIN
CAB10

(Camelus
dromedarius) 		PF07686
(V-set) 		3 THR C  11
PRO C  41
ARG C  39
 None
 0.75A 5nd7B-1kxvC:
undetectable		 5nd7B-1kxvC:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H 379
PRO H 331
ARG H 329
 None
 0.85A 5nd7B-1mcoH:
undetectable		 5nd7B-1mcoH:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 THR A  26
PRO A 102
ARG A  77
 None
None
SO4  A 999 (-3.0A)
 0.57A 5nd7B-1mdfA:
undetectable		 5nd7B-1mdfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		3 THR D 283
PRO D 329
ARG D 330
 None
 0.70A 5nd7B-1mhzD:
undetectable		 5nd7B-1mhzD:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ntg TYROSYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF01588
(tRNA_bind) 		3 THR A  19
PRO A 105
ARG A  13
 None
 0.77A 5nd7B-1ntgA:
undetectable		 5nd7B-1ntgA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5l TRANSCRIPTIONAL
REGULATOR, CRP
FAMILY

(Thermotoga
maritima) 		PF00027
(cNMP_binding) 		3 THR A  50
PRO A  75
ARG A  73
 None
 0.88A 5nd7B-1o5lA:
undetectable		 5nd7B-1o5lA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odu PUTATIVE
ALPHA-L-FUCOSIDASE

(Thermotoga
maritima) 		PF01120
(Alpha_L_fucos) 		3 THR A 125
PRO A 149
ARG A 147
 None
 0.76A 5nd7B-1oduA:
undetectable		 5nd7B-1oduA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 THR A 392
PRO A 407
ARG A 410
 None
 0.85A 5nd7B-1p2zA:
undetectable		 5nd7B-1p2zA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcv OSMOTIN

(Nicotiana
tabacum) 		PF00314
(Thaumatin) 		3 THR A 148
PRO A 134
ARG A 135
 None
 0.82A 5nd7B-1pcvA:
undetectable		 5nd7B-1pcvA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv9 XAA-PRO DIPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 THR A 329
PRO A 294
ARG A 295
 None
 0.85A 5nd7B-1pv9A:
undetectable		 5nd7B-1pv9A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q33 ADP-RIBOSE
PYROPHOSPHATASE

(Homo sapiens) 		PF00293
(NUDIX) 		3 THR A 100
PRO A 147
ARG A 148
 None
 0.87A 5nd7B-1q33A:
undetectable		 5nd7B-1q33A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 THR A 525
PRO A 383
ARG A 384
 None
 0.82A 5nd7B-1tmoA:
undetectable		 5nd7B-1tmoA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		3 THR A 140
PRO A 130
ARG A 131
 None
 0.82A 5nd7B-1urjA:
undetectable		 5nd7B-1urjA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmi PUTATIVE PHOSPHATE
ACETYLTRANSFERASE

(Escherichia
coli) 		PF01515
(PTA_PTB) 		3 THR A 193
PRO A 155
ARG A 287
 None
 0.71A 5nd7B-1vmiA:
2.8		 5nd7B-1vmiA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x6d INTERLEUKIN-16

(Homo sapiens) 		PF00595
(PDZ) 		3 THR A  19
PRO A  93
ARG A  94
 None
 0.77A 5nd7B-1x6dA:
undetectable		 5nd7B-1x6dA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		3 THR A  21
PRO A  40
ARG A 163
 None
 0.81A 5nd7B-1xr5A:
undetectable		 5nd7B-1xr5A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		3 THR 1 247
PRO 1 592
ARG 1 593
 None
None
ASP  1 704 (-3.9A)
 0.74A 5nd7B-1y791:
undetectable		 5nd7B-1y791:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzp PEROXIDASE
MANGANESE-DEPENDENT
I

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 THR A  44
PRO A 121
ARG A 122
 None
 0.72A 5nd7B-1yzpA:
undetectable		 5nd7B-1yzpA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 THR A  37
PRO A  49
ARG A  91
 None
 0.87A 5nd7B-1zk7A:
undetectable		 5nd7B-1zk7A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auk DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN

(Escherichia
coli) 		no annotation 3 THR A 108
PRO A 186
ARG A 184
 None
 0.68A 5nd7B-2aukA:
undetectable		 5nd7B-2aukA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b81 LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		3 THR A 271
PRO A 221
ARG A 219
 None
SO4  A2447 (-3.5A)
SO4  A2448 (-3.5A)
 0.83A 5nd7B-2b81A:
undetectable		 5nd7B-2b81A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR

(Homo sapiens) 		PF00515
(TPR_1)
PF13432
(TPR_16) 		3 THR A 378
PRO A 592
ARG A 590
 None
 0.87A 5nd7B-2c0lA:
undetectable		 5nd7B-2c0lA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1f WERNER SYNDROME
ATP-DEPENDENT
HELICASE

(Homo sapiens) 		PF00570
(HRDC) 		3 THR A1180
PRO A1192
ARG A1191
 None
 0.82A 5nd7B-2e1fA:
undetectable		 5nd7B-2e1fA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Gallus gallus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		3 THR A  36
PRO A  58
ARG A 157
 None
 0.80A 5nd7B-2fafA:
undetectable		 5nd7B-2fafA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima) 		PF00579
(tRNA-synt_1b) 		3 THR A 189
PRO A 222
ARG A 224
 None
None
SF4  A 400 (-4.4A)
 0.81A 5nd7B-2g36A:
undetectable		 5nd7B-2g36A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb3 ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		3 THR A 320
PRO A  15
ARG A  17
 None
 0.73A 5nd7B-2gb3A:
undetectable		 5nd7B-2gb3A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz4 HYPOTHETICAL PROTEIN
ATU1052

(Agrobacterium
fabrum) 		no annotation 3 THR A  65
PRO A 166
ARG A 167
 None
 0.65A 5nd7B-2gz4A:
undetectable		 5nd7B-2gz4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j76 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4B

(Homo sapiens) 		PF00076
(RRM_1) 		3 THR E   2
PRO E  32
ARG E  33
 None
 0.87A 5nd7B-2j76E:
undetectable		 5nd7B-2j76E:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kup FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 3

(Homo sapiens) 		PF02174
(IRS) 		3 THR A 120
PRO A  58
ARG A  56
 None
 0.86A 5nd7B-2kupA:
undetectable		 5nd7B-2kupA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 THR A 362
PRO A 377
ARG A 380
 2HP  A1620 (-4.7A)
None
None
 0.80A 5nd7B-2obeA:
undetectable		 5nd7B-2obeA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 THR A1642
PRO A1368
ARG A1373
 None
 0.62A 5nd7B-2pffA:
5.3		 5nd7B-2pffA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		3 THR A  83
PRO A  52
ARG A  47
 None
 0.88A 5nd7B-2ph3A:
7.2		 5nd7B-2ph3A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rik TITIN

(Oryctolagus
cuniculus) 		PF07679
(I-set) 		3 THR A 167
PRO A  95
ARG A  96
 None
 0.75A 5nd7B-2rikA:
undetectable		 5nd7B-2rikA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		3 THR A 368
PRO A 437
ARG A 435
 None
 0.75A 5nd7B-2vxoA:
undetectable		 5nd7B-2vxoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w59 IGY FCU3-4

(Gallus gallus) 		PF07654
(C1-set) 		3 THR A 420
PRO A 484
ARG A 485
 None
 0.87A 5nd7B-2w59A:
undetectable		 5nd7B-2w59A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wj9 INTERGENIC-REGION
PROTEIN

(Escherichia
coli) 		PF03230
(Antirestrict) 		3 THR A   9
PRO A  28
ARG A  32
 None
 0.85A 5nd7B-2wj9A:
undetectable		 5nd7B-2wj9A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Plasmodium
falciparum) 		PF00692
(dUTPase) 		3 THR A 123
PRO A  90
ARG A  91
 None
 0.64A 5nd7B-2y8cA:
undetectable		 5nd7B-2y8cA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		3 THR A 439
PRO A 434
ARG A 435
 None
 0.85A 5nd7B-2yiaA:
undetectable		 5nd7B-2yiaA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		3 THR A 442
PRO A 434
ARG A 435
 None
 0.83A 5nd7B-2yiaA:
undetectable		 5nd7B-2yiaA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		3 THR D 439
PRO D 434
ARG D 435
 None
 0.85A 5nd7B-2yibD:
undetectable		 5nd7B-2yibD:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		3 THR D 442
PRO D 434
ARG D 435
 None
 0.83A 5nd7B-2yibD:
undetectable		 5nd7B-2yibD:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywm GLUTAREDOXIN-LIKE
PROTEIN

(Aquifex
aeolicus) 		PF13192
(Thioredoxin_3) 		3 THR A 146
PRO A  83
ARG A  81
 None
 0.83A 5nd7B-2ywmA:
undetectable		 5nd7B-2ywmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 THR A 316
PRO A 342
ARG A 286
 None
 0.84A 5nd7B-2yyzA:
undetectable		 5nd7B-2yyzA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		3 THR A 128
PRO A 471
ARG A   7
 None
 0.85A 5nd7B-3al0A:
undetectable		 5nd7B-3al0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brn LIPOCALIN

(Argas
monolakensis) 		PF02098
(His_binding) 		3 THR A  76
PRO A 111
ARG A 109
 None
 0.65A 5nd7B-3brnA:
undetectable		 5nd7B-3brnA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxz PREPROTEIN
TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF07517
(SecA_DEAD) 		3 THR A 178
PRO A 222
ARG A 220
 None
 0.81A 5nd7B-3bxzA:
undetectable		 5nd7B-3bxzA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		no annotation 3 THR A  80
PRO A 192
ARG A 194
 None
 0.87A 5nd7B-3cjiA:
undetectable		 5nd7B-3cjiA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		no annotation 3 THR A 205
PRO A 192
ARG A 194
 None
 0.63A 5nd7B-3cjiA:
undetectable		 5nd7B-3cjiA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT

(Mus musculus) 		PF00503
(G-alpha) 		3 THR A 127
PRO A 202
ARG A 201
 None
 0.88A 5nd7B-3cx6A:
2.0		 5nd7B-3cx6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0k PUTATIVE
POLY(3-HYDROXYBUTYRA
TE) DEPOLYMERASE
LPQC

(Bordetella
parapertussis) 		no annotation 3 THR A 193
PRO A 110
ARG A 111
 None
 0.79A 5nd7B-3d0kA:
undetectable		 5nd7B-3d0kA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2

(Mus musculus) 		PF04916
(Phospholip_B) 		3 THR A 209
PRO A 290
ARG A 287
 NAG  A  12 (-3.6A)
None
None
 0.82A 5nd7B-3fgwA:
undetectable		 5nd7B-3fgwA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		3 THR A4340
PRO A4336
ARG A4334
 NA  A5001 (-4.9A)
None
None
 0.79A 5nd7B-3g1nA:
undetectable		 5nd7B-3g1nA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		3 THR A  58
PRO A 110
ARG A 100
 None
None
AMP  A 401 (-2.8A)
 0.87A 5nd7B-3g1zA:
undetectable		 5nd7B-3g1zA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4s 50S RIBOSOMAL
PROTEIN L6P

(Haloarcula
marismortui) 		PF00347
(Ribosomal_L6) 		3 THR E  61
PRO E   1
ARG E   2
 A  02792 ( 3.9A)
None
None
 0.87A 5nd7B-3g4sE:
undetectable		 5nd7B-3g4sE:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdo UNCHARACTERIZED
OXIDOREDUCTASE YVAA

(Bacillus
subtilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 THR A 156
PRO A 245
ARG A 246
 None
 0.86A 5nd7B-3gdoA:
undetectable		 5nd7B-3gdoA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3god CAS1

(Pseudomonas
aeruginosa) 		PF01867
(Cas_Cas1) 		3 THR A  11
PRO A 106
ARG A  76
 None
 0.85A 5nd7B-3godA:
undetectable		 5nd7B-3godA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrx PROBABLE ENOYL-COA
HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		3 THR A 233
PRO A 249
ARG A 250
 None
 0.85A 5nd7B-3hrxA:
undetectable		 5nd7B-3hrxA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		3 THR A 251
PRO A 349
ARG A 352
 None
 0.71A 5nd7B-3i6rA:
3.2		 5nd7B-3i6rA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN

(Cupriavidus
pinatubonensis) 		PF07063
(DUF1338) 		3 THR A 217
PRO A 148
ARG A 150
 None
MLY  A  88 ( 4.6A)
None
 0.76A 5nd7B-3iuzA:
undetectable		 5nd7B-3iuzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP3

(Saccharomyces
cerevisiae) 		PF06544
(DUF1115)
PF08572
(PRP3) 		3 THR K 427
PRO K 377
ARG K 371
 None
None
C  D  85 ( 3.8A)
 0.78A 5nd7B-3jcmK:
undetectable		 5nd7B-3jcmK:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv3 INTERSECTIN-1

(Mus musculus) 		PF00621
(RhoGEF)
PF14604
(SH3_9) 		3 THR A1253
PRO A1371
ARG A1374
 None
 0.76A 5nd7B-3jv3A:
undetectable		 5nd7B-3jv3A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6f T-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 THR A  56
PRO A  18
ARG A  19
 None
 0.68A 5nd7B-3k6fA:
undetectable		 5nd7B-3k6fA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl7 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Parabacteroides
distasonis) 		PF13483
(Lactamase_B_3) 		3 THR A  78
PRO A 147
ARG A 148
 None
 0.84A 5nd7B-3kl7A:
undetectable		 5nd7B-3kl7A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krb ALDOSE REDUCTASE

(Giardia
intestinalis) 		PF00248
(Aldo_ket_red) 		3 THR A  29
PRO A   5
ARG A   6
 None
 0.78A 5nd7B-3krbA:
undetectable		 5nd7B-3krbA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		3 THR A 273
PRO A 120
ARG A 123
 None
None
HEM  A 481 (-3.4A)
 0.83A 5nd7B-3l4dA:
undetectable		 5nd7B-3l4dA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lao ENOYL-COA
HYDRATASE/ISOMERASE

(Pseudomonas
aeruginosa) 		PF00378
(ECH_1) 		3 THR A  67
PRO A  93
ARG A 101
 None
 0.77A 5nd7B-3laoA:
undetectable		 5nd7B-3laoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE

(Idiomarina
loihiensis) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		3 THR A 239
PRO A  43
ARG A 233
 None
None
LLP  A  46 ( 3.6A)
 0.86A 5nd7B-3llxA:
undetectable		 5nd7B-3llxA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00496
(SBP_bac_5) 		3 THR A 364
PRO A 355
ARG A 356
 None
 0.68A 5nd7B-3lvuA:
undetectable		 5nd7B-3lvuA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE

(Enterovirus A) 		PF00680
(RdRP_1) 		3 THR A  21
PRO A  40
ARG A 163
 None
None
BUP  A 464 (-2.6A)
 0.76A 5nd7B-3n6nA:
undetectable		 5nd7B-3n6nA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nip 3-GUANIDINOPROPIONAS
E

(Pseudomonas
aeruginosa) 		PF00491
(Arginase) 		3 THR A 254
PRO A 168
ARG A 170
 None
 0.87A 5nd7B-3nipA:
undetectable		 5nd7B-3nipA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		3 THR A 144
PRO A 139
ARG A 140
 None
 0.83A 5nd7B-3nnkA:
undetectable		 5nd7B-3nnkA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 SEMAPHORIN-4D

(Homo sapiens) 		PF00047
(ig)
PF01403
(Sema)
PF01437
(PSI) 		3 THR A 266
PRO A 365
ARG A 366
 None
 0.86A 5nd7B-3ol2A:
undetectable		 5nd7B-3ol2A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouu BIOTIN CARBOXYLASE

(Campylobacter
jejuni) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 THR A 252
PRO A 244
ARG A 228
 None
 0.86A 5nd7B-3ouuA:
undetectable		 5nd7B-3ouuA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p13 D-RIBOSE PYRANASE

(Staphylococcus
aureus) 		PF05025
(RbsD_FucU) 		3 THR A  27
PRO A  51
ARG A  52
 None
 0.69A 5nd7B-3p13A:
undetectable		 5nd7B-3p13A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		3 THR A 293
PRO A 344
ARG A 341
 HEM  A 501 (-4.0A)
None
None
 0.86A 5nd7B-3p3lA:
undetectable		 5nd7B-3p3lA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 THR A 234
PRO A 343
ARG A 317
 None
 0.46A 5nd7B-3p4sA:
undetectable		 5nd7B-3p4sA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aspergillus
nidulans) 		PF01179
(Cu_amine_oxid)
PF09248
(DUF1965) 		3 THR A 206
PRO A 164
ARG A 198
 None
 0.84A 5nd7B-3pgbA:
undetectable		 5nd7B-3pgbA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pig BETA-FRUCTOFURANOSID
ASE

(Bifidobacterium
longum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 THR A   5
PRO A 182
ARG A 180
 None
 0.82A 5nd7B-3pigA:
undetectable		 5nd7B-3pigA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		3 THR A 894
PRO A 586
ARG A 584
 None
 0.83A 5nd7B-3pihA:
undetectable		 5nd7B-3pihA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnr PBICP-C

(Plasmodium
berghei) 		PF09394
(Inhibitor_I42)
PF12628
(Inhibitor_I71) 		3 THR B 258
PRO B 340
ARG B 336
 None
 0.86A 5nd7B-3pnrB:
undetectable		 5nd7B-3pnrB:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbv INTERSECTIN-1

(Homo sapiens) 		PF00621
(RhoGEF)
PF16652
(PH_13) 		3 THR B1260
PRO B1378
ARG B1381
 None
 0.77A 5nd7B-3qbvB:
undetectable		 5nd7B-3qbvB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qit POLYKETIDE SYNTHASE

(Moorea
producens) 		PF00561
(Abhydrolase_1) 		3 THR A 204
PRO A 155
ARG A 195
 None
 0.82A 5nd7B-3qitA:
4.0		 5nd7B-3qitA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE

(Francisella
tularensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 THR A 161
PRO A  58
ARG A 166
 None
 0.82A 5nd7B-3qtyA:
undetectable		 5nd7B-3qtyA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rvx PEPTIDASE 1

(Dermatophagoides
pteronyssinus) 		PF00112
(Peptidase_C1) 		3 THR A  21
PRO A  11
ARG A 128
 None
 0.83A 5nd7B-3rvxA:
undetectable		 5nd7B-3rvxA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tek THERMODBP-SINGLE
STRANDED DNA BINDING
PROTEIN

(Thermoproteus
tenax) 		no annotation 3 THR A  32
PRO A  46
ARG A  49
 None
 0.73A 5nd7B-3tekA:
undetectable		 5nd7B-3tekA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3th1 CHLOROCATECHOL
1,2-DIOXYGENASE

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		3 THR A  94
PRO A 138
ARG A 143
 None
 0.79A 5nd7B-3th1A:
undetectable		 5nd7B-3th1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tov GLYCOSYL TRANSFERASE
FAMILY 9

(Veillonella
parvula) 		PF01075
(Glyco_transf_9) 		3 THR A 304
PRO A 199
ARG A 197
 None
 0.78A 5nd7B-3tovA:
5.5		 5nd7B-3tovA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo5 AP-4-A PHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF01230
(HIT) 		3 THR A 183
PRO A 131
ARG A 130
 None
 0.59A 5nd7B-3wo5A:
undetectable		 5nd7B-3wo5A:
18.59