SIMILAR PATTERNS OF AMINO ACIDS FOR 5ND7_B_TA1B601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c72 PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Gallus gallus) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 VAL A 162
LEU A  99
ALA A 159
PHE A 147
LEU A 180
 None
 1.17A 5nd7B-1c72A:
undetectable		 5nd7B-1c72A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcq PYK2-ASSOCIATED
PROTEIN BETA

(Mus musculus) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		5 VAL A 382
LEU A 417
ALA A 420
SER A 423
LEU A 429
 None
 1.19A 5nd7B-1dcqA:
undetectable		 5nd7B-1dcqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnn CELL DIVISION
CONTROL PROTEIN 6

(Pyrobaculum
aerophilum) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 VAL A 170
LEU A 136
ALA A 133
ARG A 146
LEU A 161
 None
 1.22A 5nd7B-1fnnA:
undetectable		 5nd7B-1fnnA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH

(Escherichia
coli) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		5 VAL A 103
ASP A 105
ARG A 114
ARG A 153
LEU A 134
 None
 1.18A 5nd7B-1gz0A:
2.1		 5nd7B-1gz0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL B 293
ASP B 292
LEU B 165
ALA B 345
SER B 348
 None
 1.19A 5nd7B-1tqyB:
undetectable		 5nd7B-1tqyB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5v CITE

(Mycobacterium
tuberculosis) 		PF03328
(HpcH_HpaI) 		5 VAL A  39
ASP A  37
LEU A  80
LEU A  51
ALA A  15
 None
 1.08A 5nd7B-1u5vA:
undetectable		 5nd7B-1u5vA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		5 ASP A 360
GLU A 450
LEU A 403
LEU A 348
ALA A 349
 None
 1.20A 5nd7B-1ua4A:
4.1		 5nd7B-1ua4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unp RAC-ALPHA
SERINE/THREONINE
KINASE

(Homo sapiens) 		PF00169
(PH) 		5 VAL A 106
LEU A  12
ALA A 102
ARG A  86
LEU A  62
 None
 1.21A 5nd7B-1unpA:
undetectable		 5nd7B-1unpA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7n THROMBOPOIETIN

(Homo sapiens) 		PF00758
(EPO_TPO) 		5 LEU V 135
LEU V 100
ALA V 103
SER V 106
ARG V  17
 None
 1.11A 5nd7B-1v7nV:
undetectable		 5nd7B-1v7nV:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Bacillus
subtilis) 		PF02504
(FA_synthesis) 		5 VAL A  72
LEU A 284
LEU A 104
ALA A 103
ARG A 114
 None
 1.20A 5nd7B-1vi1A:
2.5		 5nd7B-1vi1A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 GLU A 408
HIS A 432
LEU A 433
ALA A 436
LEU A 406
 None
 1.17A 5nd7B-1wdtA:
2.6		 5nd7B-1wdtA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxq GTP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF08438
(MMR_HSR1_C) 		5 VAL A 312
ASP A 315
LEU A 134
LEU A 105
ALA A 104
 None
 1.16A 5nd7B-1wxqA:
2.1		 5nd7B-1wxqA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2b PROLINE
IMINOPEPTIDASE

(Serratia
marcescens) 		PF00561
(Abhydrolase_1) 		5 VAL A 130
GLU A 128
LEU A 279
LEU A 120
ALA A 123
 None
 1.08A 5nd7B-1x2bA:
3.3		 5nd7B-1x2bA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bas YKUI PROTEIN

(Bacillus
subtilis) 		PF00563
(EAL)
PF10388
(YkuI_C) 		5 ASP A 367
LEU A 206
LEU A 192
SER A 185
ARG A 200
 None
 1.17A 5nd7B-2basA:
undetectable		 5nd7B-2basA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE

(Vitis vinifera) 		PF00201
(UDPGT) 		5 ASP A 407
ALA A 346
ARG A 391
ARG A 419
LEU A 418
 None
 1.22A 5nd7B-2c1zA:
5.8		 5nd7B-2c1zA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgr RING FINGER AND KH
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00013
(KH_1) 		5 GLU A 166
HIS A 171
LEU A 174
ALA A 170
ARG A 132
 None
 1.16A 5nd7B-2dgrA:
undetectable		 5nd7B-2dgrA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 LEU A 337
LEU A 420
ALA A 419
ARG A 332
LEU A  55
 None
 1.20A 5nd7B-2e7uA:
undetectable		 5nd7B-2e7uA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4i HYPOTHETICAL PROTEIN
TM0957

(Thermotoga
maritima) 		PF10054
(DUF2291) 		5 VAL A 167
GLU A 166
LEU A  60
ARG A  46
LEU A 159
 None
 1.15A 5nd7B-2f4iA:
undetectable		 5nd7B-2f4iA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		5 VAL A 209
ASP A 210
LEU A 377
LEU A  69
ARG A 183
 None
ZN  A1001 (-2.0A)
None
None
None
 1.07A 5nd7B-2gsnA:
undetectable		 5nd7B-2gsnA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 VAL A 406
ASP A 357
HIS A 479
LEU A 482
LEU A 354
 VAL  A 406 ( 0.6A)
ASP  A 357 ( 0.6A)
HIS  A 479 ( 1.0A)
LEU  A 482 ( 0.6A)
LEU  A 354 ( 0.6A)
 1.14A 5nd7B-2nvvA:
undetectable		 5nd7B-2nvvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyo UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Deinococcus
geothermalis) 		PF02627
(CMD) 		5 GLU A 135
LEU A 105
ALA A 131
ARG A 102
ARG A 119
 None
 1.20A 5nd7B-2oyoA:
undetectable		 5nd7B-2oyoA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rpb HYPOTHETICAL
MEMBRANE PROTEIN

(Pyrococcus
horikoshii) 		PF01145
(Band_7) 		5 VAL A  75
ASP A  74
LEU A 146
ALA A 119
ARG A 163
 None
 1.13A 5nd7B-2rpbA:
undetectable		 5nd7B-2rpbA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus) 		PF14589
(NrfD_2) 		5 GLU C  12
LEU C 194
HIS C 201
LEU C 202
ALA C 245
 None
 1.05A 5nd7B-2vpwC:
undetectable		 5nd7B-2vpwC:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvg KINESIN-2

(Giardia
intestinalis) 		PF00225
(Kinesin) 		5 LEU A 237
HIS A 123
LEU A 124
ALA A 127
SER A 130
 None
 1.15A 5nd7B-2vvgA:
undetectable		 5nd7B-2vvgA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		5 VAL A 352
LEU A 297
LEU A 145
ALA A 148
SER A 151
 None
 1.05A 5nd7B-2wsxA:
undetectable		 5nd7B-2wsxA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgd 3 REPEAT SYNTHETIC
ANKYRIN

(-) 		PF12796
(Ank_2) 		5 VAL A  40
ASP A  38
GLU A  39
LEU A 105
ALA A  32
 None
CD  A 413 ( 2.4A)
CD  A 410 ( 2.1A)
None
None
 1.09A 5nd7B-2zgdA:
undetectable		 5nd7B-2zgdA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2

(Escherichia
coli) 		PF00730
(HhH-GPD)
PF06029
(AlkA_N) 		5 ASP A 201
LEU A 235
LEU A 225
ALA A 230
ARG A 217
 None
 1.19A 5nd7B-3cwuA:
undetectable		 5nd7B-3cwuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxl N-CHIMERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		5 VAL A 404
LEU A 394
PHE A 422
ARG A 281
LEU A 343
 None
 1.12A 5nd7B-3cxlA:
undetectable		 5nd7B-3cxlA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN

(Neisseria
gonorrhoeae) 		PF00588
(SpoU_methylase) 		5 VAL A  93
GLU A  91
LEU A 151
LEU A  96
ALA A  99
 None
 0.94A 5nd7B-3ic6A:
undetectable		 5nd7B-3ic6A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iie 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Yersinia
pseudotuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 ASP A  58
GLU A  59
LEU A  88
ARG A  66
LEU A  65
 None
 0.93A 5nd7B-3iieA:
4.0		 5nd7B-3iieA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrv PROTEIN K7

(Vaccinia virus) 		PF06227
(Poxvirus) 		5 VAL A  63
ASP A  62
LEU A 131
LEU A  98
LEU A  57
 None
 1.18A 5nd7B-3jrvA:
undetectable		 5nd7B-3jrvA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR

(Homo sapiens) 		PF13621
(Cupin_8) 		5 ASP A  49
GLU A  53
LEU A  69
PHE A 206
ARG A 177
 None
 1.11A 5nd7B-3kcxA:
undetectable		 5nd7B-3kcxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		5 GLU A  86
LEU A  75
ALA A  78
SER A  81
PHE A 494
 None
 1.06A 5nd7B-3nbuA:
undetectable		 5nd7B-3nbuA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz APC VARIANT PROTEIN

(Homo sapiens) 		PF00514
(Arm) 		5 GLU A 443
LEU A 488
SER A 494
ARG A 527
LEU A 479
 None
 1.18A 5nd7B-3nmzA:
undetectable		 5nd7B-3nmzA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nu8 AMINOTRANSFERASE
WBPE

(Pseudomonas
aeruginosa) 		PF01041
(DegT_DnrJ_EryC1) 		5 ASP A 156
GLU A 155
LEU A 238
LEU A 187
SER A 170
 LLP  A 185 ( 2.9A)
None
None
None
None
 1.10A 5nd7B-3nu8A:
undetectable		 5nd7B-3nu8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		5 LEU A 201
LEU A 213
ALA A 216
SER A 219
ARG A 173
 None
 1.19A 5nd7B-3o7wA:
undetectable		 5nd7B-3o7wA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnz PHOSPHOTRIESTERASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF02126
(PTE) 		5 VAL A  64
ASP A  65
GLU A  23
LEU A 211
SER A 270
 None
 1.13A 5nd7B-3pnzA:
undetectable		 5nd7B-3pnzA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pw9 UPF0603 PROTEIN
AT1G54780,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04536
(TPM_phosphatase) 		5 LEU A 107
LEU A 115
ALA A 219
PHE A 132
LEU A 202
 None
 1.11A 5nd7B-3pw9A:
undetectable		 5nd7B-3pw9A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shu TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ) 		5 VAL A  35
ALA A  41
SER A  39
PHE A  12
LEU A  72
 None
 1.01A 5nd7B-3shuA:
undetectable		 5nd7B-3shuA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shw TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		5 VAL A 450
ALA A 456
SER A 454
PHE A 427
LEU A 487
 None
 1.11A 5nd7B-3shwA:
2.8		 5nd7B-3shwA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		5 VAL A 210
GLU A 247
LEU A  39
ALA A 281
ARG A 288
 None
 1.17A 5nd7B-3tbhA:
undetectable		 5nd7B-3tbhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsv TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ) 		5 VAL A 450
ALA A 456
SER A 454
PHE A 427
LEU A 487
 None
 1.14A 5nd7B-3tsvA:
undetectable		 5nd7B-3tsvA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdj ENCA BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		5 GLU A 197
LEU A 148
LEU A 152
ARG A  83
LEU A 199
 None
 1.11A 5nd7B-3zdjA:
undetectable		 5nd7B-3zdjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 VAL A 289
LEU A 193
LEU A 267
ALA A 266
ARG A 189
 None
 1.20A 5nd7B-4b45A:
31.8		 5nd7B-4b45A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b46 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 LEU A 197
LEU A 296
ALA A 295
SER A 324
ARG A 193
 None
 1.18A 5nd7B-4b46A:
31.5		 5nd7B-4b46A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzk PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12931
(Sec16_C) 		5 VAL A 740
GLU A 736
LEU A 422
LEU A 718
LEU A 726
 None
 1.11A 5nd7B-4bzkA:
undetectable		 5nd7B-4bzkA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN

(Arabidopsis
thaliana) 		PF16035
(Chalcone_2) 		5 ASP A  50
LEU A 196
ALA A 199
PHE A  76
LEU A  57
 None
 1.19A 5nd7B-4dooA:
undetectable		 5nd7B-4dooA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f67 UPF0176 PROTEIN
LPG2838

(Legionella
pneumophila) 		PF00581
(Rhodanese) 		5 ASP A 135
GLU A 137
LEU A 165
ARG A 163
ARG A 182
 None
 1.10A 5nd7B-4f67A:
undetectable		 5nd7B-4f67A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8k 2-5A-DEPENDENT
RIBONUCLEASE

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 VAL A  33
ASP A  37
GLU A  36
LEU A  63
ALA A  66
 None
 0.98A 5nd7B-4g8kA:
undetectable		 5nd7B-4g8kA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 VAL A 136
LEU A 160
HIS A 176
LEU A 177
ARG A 164
 None
None
None
B7N  A 401 (-4.3A)
None
 1.21A 5nd7B-4j7qA:
undetectable		 5nd7B-4j7qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kws D-MANNONATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLU A 131
LEU A 235
ALA A 199
ARG A 149
ARG A 203
 None
 1.17A 5nd7B-4kwsA:
undetectable		 5nd7B-4kwsA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 VAL A  90
GLU A  71
LEU A  86
ALA A  83
LEU A 170
 None
SAH  A 301 ( 4.7A)
None
None
None
 1.10A 5nd7B-4lecA:
undetectable		 5nd7B-4lecA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 VAL A 137
GLU A 118
LEU A 133
ALA A 130
LEU A 220
 None
UNX  A1016 ( 2.6A)
None
None
None
 1.14A 5nd7B-4mtlA:
2.4		 5nd7B-4mtlA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqw ECF RNA POLYMERASE
SIGMA FACTOR SIGK

(Mycobacterium
tuberculosis) 		PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		5 VAL A 158
GLU A 157
LEU A 177
ALA A 148
ARG A 174
 None
 1.12A 5nd7B-4nqwA:
undetectable		 5nd7B-4nqwA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3m BLOOM SYNDROME
PROTEIN

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF00570
(HRDC)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 GLU A 900
HIS A 963
LEU A 991
ARG A1000
LEU A1001
 None
 1.22A 5nd7B-4o3mA:
undetectable		 5nd7B-4o3mA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 VAL B  33
ASP B  37
GLU B  36
LEU B  63
ALA B  66
 None
 0.98A 5nd7B-4oavB:
undetectable		 5nd7B-4oavB:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obs ALPHA-L-IDURONIDASE

(Homo sapiens) 		PF01229
(Glyco_hydro_39) 		5 VAL A 172
LEU A  94
LEU A 159
ALA A 160
LEU A 218
 None
 1.15A 5nd7B-4obsA:
undetectable		 5nd7B-4obsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqs CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 ASP A 187
GLU A 188
LEU A 235
LEU A 196
ALA A 192
 None
 1.15A 5nd7B-4oqsA:
undetectable		 5nd7B-4oqsA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pll AT1G02740

(Arabidopsis
thaliana) 		PF11717
(Tudor-knot) 		5 VAL A  85
ASP A  95
GLU A  96
LEU A  59
ALA A  60
 None
 1.09A 5nd7B-4pllA:
undetectable		 5nd7B-4pllA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru4 TAIL SPIKE PROTEIN
GP49

(Pseudomonas
virus LKA1) 		PF13229
(Beta_helix) 		5 LEU A 682
ALA A 764
PHE A 703
ARG A 685
LEU A 742
 None
 1.15A 5nd7B-4ru4A:
undetectable		 5nd7B-4ru4A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvo MALATE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASP A  60
GLU A  58
LEU A  22
ARG A  41
LEU A  52
 None
 1.04A 5nd7B-4tvoA:
5.6		 5nd7B-4tvoA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		5 LEU B 455
ALA B 265
PHE B 318
ARG B 439
LEU B 248
 None
 1.14A 5nd7B-4tx2B:
undetectable		 5nd7B-4tx2B:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yx7 OXYGEN-REGULATED
INVASION PROTEIN
ORGB,ENDOLYSIN

(Escherichia
virus T4;
Salmonella
enterica) 		PF00959
(Phage_lysozyme) 		5 VAL C 136
GLU C 141
ALA C 107
ARG C 113
LEU C 112
 None
 1.20A 5nd7B-4yx7C:
undetectable		 5nd7B-4yx7C:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA

(Mycolicibacterium
thermoresistibile) 		no annotation 5 VAL C 299
LEU C 291
ALA C 264
SER C 127
LEU C 261
 None
 1.21A 5nd7B-5cw2C:
3.0		 5nd7B-5cw2C:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgt BENZOYLFORMATE
DECARBOXYLASE

(Pseudomonas
putida) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A 211
ASP A 210
LEU A 197
LEU A 223
ALA A 322
 None
 1.20A 5nd7B-5dgtA:
undetectable		 5nd7B-5dgtA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 VAL A 968
LEU A1028
LEU A1002
ALA A1005
ARG A 985
 None
 1.07A 5nd7B-5eawA:
undetectable		 5nd7B-5eawA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed7 TEGUMENT PROTEIN
UL21

(Human
alphaherpesvirus
1) 		PF03252
(Herpes_UL21) 		5 VAL A 495
ASP A 494
ALA A 403
PHE A 462
LEU A 488
 None
 1.22A 5nd7B-5ed7A:
undetectable		 5nd7B-5ed7A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ekz TRANSLATIONAL
ACTIVATOR OF
CYTOCHROME C OXIDASE
1

(Mus musculus) 		PF01709
(Transcrip_reg) 		5 VAL A 215
GLU A 217
LEU A 206
ALA A 203
ARG A 240
 None
 1.08A 5nd7B-5ekzA:
undetectable		 5nd7B-5ekzA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exk LIPOYL SYNTHASE

(Mycobacterium
tuberculosis) 		PF04055
(Radical_SAM)
PF16881
(LIAS_N) 		5 ASP A 227
GLU A 228
LEU A 236
ALA A 232
LEU A 220
 None
 1.21A 5nd7B-5exkA:
3.4		 5nd7B-5exkA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg STRIGOLACTONE
ESTERASE D14

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		5 VAL A  76
ASP A  78
LEU A 119
ALA A 106
PHE A 114
 None
 1.14A 5nd7B-5hzgA:
3.4		 5nd7B-5hzgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 ASP A 331
LEU A 194
LEU A  53
ALA A 337
ARG A 134
 None
 1.22A 5nd7B-5ihrA:
undetectable		 5nd7B-5ihrA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5il6 POLYKETIDE
SYNTHASE/NONRIBOSOMA
L PEPTIDE SYNTHETASE
HYBRID RZXB

(Pseudomonas
protegens) 		PF14765
(PS-DH) 		5 VAL A4511
LEU A4624
ARG A4611
ARG A4519
LEU A4577
 None
 1.16A 5nd7B-5il6A:
undetectable		 5nd7B-5il6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in1 MRG701

(Oryza sativa) 		PF11717
(Tudor-knot) 		5 VAL A  44
ASP A  54
GLU A  55
LEU A  18
ALA A  19
 None
 1.12A 5nd7B-5in1A:
undetectable		 5nd7B-5in1A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		5 VAL A 648
LEU A 569
LEU A 634
SER A 703
LEU A 695
 None
 1.19A 5nd7B-5jjhA:
undetectable		 5nd7B-5jjhA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9o HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 GLU F  89
LEU F  71
ALA F  67
ARG F 229
ARG F 109
 None
 1.22A 5nd7B-5k9oF:
undetectable		 5nd7B-5k9oF:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 ASP A  26
LEU A 215
HIS A 227
ARG A 317
LEU A 360
 None
 1.09A 5nd7B-5mjsA:
55.5		 5nd7B-5mjsA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 6 ASP A  26
LEU A 215
HIS A 227
LEU A 228
ALA A 231
LEU A 360
 None
 0.93A 5nd7B-5mjsA:
55.5		 5nd7B-5mjsA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 GLU A  27
LEU A 215
HIS A 227
ARG A 317
LEU A 360
 None
 1.19A 5nd7B-5mjsA:
55.5		 5nd7B-5mjsA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 6 GLU A  27
LEU A 215
HIS A 227
LEU A 228
ALA A 231
LEU A 360
 None
 1.16A 5nd7B-5mjsA:
55.5		 5nd7B-5mjsA:
59.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms7 LEGIONELLA
PNEUMOPHILA EFFECTOR
PROTEIN RAVZ

(Legionella
pneumophila) 		no annotation 5 ASP A 236
LEU A 180
LEU A 143
ALA A 231
LEU A 239
 None
 1.08A 5nd7B-5ms7A:
undetectable		 5nd7B-5ms7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtf RHOMBOID PROTEASE
GLPG

(Escherichia
coli) 		no annotation 5 VAL A 203
LEU A 179
ALA A 182
SER A 185
LEU A 143
 None
 1.16A 5nd7B-5mtfA:
undetectable		 5nd7B-5mtfA:
15.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 9 VAL B  23
ASP B  26
GLU B  27
LEU B 217
HIS B 229
ALA B 233
SER B 236
PHE B 272
LEU B 371
 None
 1.22A 5nd7B-5n5nB:
55.8		 5nd7B-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 10 VAL B  23
ASP B  26
GLU B  27
LEU B 217
HIS B 229
LEU B 230
ALA B 233
PHE B 272
ARG B 320
LEU B 371
 None
 1.23A 5nd7B-5n5nB:
55.8		 5nd7B-5n5nB:
97.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 5 ASP A 363
GLU A 453
LEU A 406
LEU A 351
ALA A 352
 None
 1.16A 5nd7B-5o0jA:
4.2		 5nd7B-5o0jA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oar BETA-HEXOSAMINIDASE

(Aspergillus
oryzae) 		no annotation 5 VAL B 113
LEU B 150
ALA B 149
PHE B 153
LEU A  46
 None
 1.21A 5nd7B-5oarB:
undetectable		 5nd7B-5oarB:
13.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ucy TUBULIN ALPHA CHAIN

(Tetrahymena
thermophila) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 GLU A  27
LEU A 217
LEU A 230
SER A 236
ARG A 320
 None
 0.86A 5nd7B-5ucyA:
50.2		 5nd7B-5ucyA:
41.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 5 VAL A 123
ASP A  52
PHE A  79
ARG A  64
LEU A  92
 None
 1.09A 5nd7B-5vm9A:
undetectable		 5nd7B-5vm9A:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		7 VAL B  23
ASP B  26
GLU B  27
LEU B 215
LEU B 228
ARG B 318
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
None
None
None
TA1  B 502 (-3.7A)
 1.12A 5nd7B-5w3jB:
55.9		 5nd7B-5w3jB:
75.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		6 VAL B  23
ASP B  26
GLU B  27
SER B 234
ARG B 318
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
TA1  B 502 ( 4.9A)
None
TA1  B 502 (-3.7A)
 1.10A 5nd7B-5w3jB:
55.9		 5nd7B-5w3jB:
75.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 5 VAL A 122
LEU A 265
LEU A  47
ALA A 206
LEU A 209
 None
 1.18A 5nd7B-5wm4A:
undetectable		 5nd7B-5wm4A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wql TAIL-SPECIFIC
PROTEASE

(Escherichia
coli) 		no annotation 5 VAL C 469
LEU C 392
ALA C 458
ARG C 448
ARG C 513
 None
 1.21A 5nd7B-5wqlC:
2.0		 5nd7B-5wqlC:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvc CASPASE

(Homo sapiens) 		no annotation 5 ASP D 223
LEU D 289
LEU D 216
ALA D 255
LEU D 229
 None
None
CSO  D 212 ( 3.4A)
None
None
 1.12A 5nd7B-5wvcD:
undetectable		 5nd7B-5wvcD:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 5 ASP A 545
LEU A 560
ALA A 563
SER A 566
PHE A 606
 None
 1.16A 5nd7B-5x3jA:
undetectable		 5nd7B-5x3jA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 5 VAL A 688
ASP A 686
LEU A 698
ALA A 701
LEU A 604
 None
ANP  A 901 (-2.7A)
None
None
None
 1.08A 5nd7B-5x9wA:
undetectable		 5nd7B-5x9wA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS02G0668100 PROTEIN

(Oryza sativa) 		PF00348
(polyprenyl_synt) 		5 VAL C  14
ASP C  13
GLU C  17
ALA C  74
ARG C 278
 None
 1.20A 5nd7B-5xn6C:
undetectable		 5nd7B-5xn6C:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 5 VAL A  75
ASP A  77
LEU A 118
ALA A 105
PHE A 113
 None
 1.18A 5nd7B-6ap6A:
3.2		 5nd7B-6ap6A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5v TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5

(Oryctolagus
cuniculus) 		no annotation 5 GLU A 104
LEU A  61
LEU A  65
ALA A 101
LEU A  83
 None
 1.21A 5nd7B-6b5vA:
undetectable		 5nd7B-6b5vA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 5 VAL K 903
LEU K 702
ALA K 705
SER K 708
LEU K 736
 None
 1.22A 5nd7B-6d6qK:
undetectable		 5nd7B-6d6qK:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Homo sapiens) 		no annotation 5 ASP A 635
GLU A 634
LEU A 316
ARG A 632
LEU A 277
 None
 0.94A 5nd7B-6d7tA:
undetectable		 5nd7B-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj POLYADENYLATION
FACTOR SUBUNIT
2,POLYADENYLATION
FACTOR SUBUNIT 2
PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 5 ASP A  62
LEU A 117
ALA A  83
PHE A 109
ARG D  74
 None
 1.03A 5nd7B-6eojA:
undetectable		 5nd7B-6eojA:
16.26