SIMILAR PATTERNS OF AMINO ACIDS FOR 5ND3_B_TA1B601_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ak0 | P1 NUCLEASE (Penicilliumcitrinum) |
PF02265(S1-P1_nuclease) | 5 | GLU A 46HIS A 164LEU A 4ALA A 3SER A 42 | None | 1.26A | 5nd3B-1ak0A:undetectable | 5nd3B-1ak0A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dcq | PYK2-ASSOCIATEDPROTEIN BETA (Mus musculus) |
PF01412(ArfGap)PF12796(Ank_2) | 5 | VAL A 382LEU A 442LEU A 417ALA A 420SER A 423 | None | 1.23A | 5nd3B-1dcqA:undetectable | 5nd3B-1dcqA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jr1 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 (Cricetulusgriseus) |
PF00478(IMPDH)PF00571(CBS) | 5 | LEU A 377ALA A 381SER A 351THR A 52PRO A 360 | None | 1.22A | 5nd3B-1jr1A:undetectable | 5nd3B-1jr1A:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k85 | CHITINASE A1 (Bacilluscirculans) |
PF00041(fn3) | 5 | VAL A 589LEU A 600ALA A 626SER A 583THR A 602 | None | 1.27A | 5nd3B-1k85A:undetectable | 5nd3B-1k85A:13.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kbl | PYRUVATE PHOSPHATEDIKINASE ([Clostridium]symbiosum) |
PF00391(PEP-utilizers)PF01326(PPDK_N)PF02896(PEP-utilizers_C) | 5 | ASP A 355GLU A 356LEU A 373ALA A 350ARG A 259 | None | 1.23A | 5nd3B-1kblA:2.0 | 5nd3B-1kblA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kbl | PYRUVATE PHOSPHATEDIKINASE ([Clostridium]symbiosum) |
PF00391(PEP-utilizers)PF01326(PPDK_N)PF02896(PEP-utilizers_C) | 5 | ASP A 355GLU A 356LEU A 376ALA A 350ARG A 259 | None | 1.26A | 5nd3B-1kblA:2.0 | 5nd3B-1kblA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kbl | PYRUVATE PHOSPHATEDIKINASE ([Clostridium]symbiosum) |
PF00391(PEP-utilizers)PF01326(PPDK_N)PF02896(PEP-utilizers_C) | 5 | VAL A 354ASP A 355GLU A 356LEU A 373ARG A 259 | None | 1.17A | 5nd3B-1kblA:2.0 | 5nd3B-1kblA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kbl | PYRUVATE PHOSPHATEDIKINASE ([Clostridium]symbiosum) |
PF00391(PEP-utilizers)PF01326(PPDK_N)PF02896(PEP-utilizers_C) | 5 | VAL A 354ASP A 355GLU A 356LEU A 864ARG A 259 | None | 1.26A | 5nd3B-1kblA:2.0 | 5nd3B-1kblA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m64 | FLAVOCYTOCHROME C3 (Shewanellafrigidimarina) |
PF00890(FAD_binding_2)PF14537(Cytochrom_c3_2) | 5 | VAL A 220ASP A 221HIS A 245ALA A 174THR A 186 | None | 1.13A | 5nd3B-1m64A:undetectable | 5nd3B-1m64A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1px5 | 2'-5'-OLIGOADENYLATESYNTHETASE 1 (Sus scrofa) |
PF01909(NTP_transf_2)PF10421(OAS1_C) | 5 | VAL A 78ASP A 76LEU A 172ALA A 151ARG A 94 | None | 0.76A | 5nd3B-1px5A:undetectable | 5nd3B-1px5A:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q51 | MENB (Mycobacteriumtuberculosis) |
PF00378(ECH_1) | 5 | ASP A 81LEU A 34HIS A 75ALA A 76THR A 38 | None | 1.24A | 5nd3B-1q51A:undetectable | 5nd3B-1q51A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkz | PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (Thermotogamaritima) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 5 | HIS A 365LEU A 364ALA A 347THR A 393ARG A 395 | None | 1.00A | 5nd3B-1vkzA:undetectable | 5nd3B-1vkzA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c0h | MANNANENDO-1,4-BETA-MANNOSIDASE (Mytilus edulis) |
PF00150(Cellulase) | 5 | VAL A 96GLU A 89LEU A 156ALA A 155THR A 124 | None | 1.18A | 5nd3B-2c0hA:3.2 | 5nd3B-2c0hA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2db0 | 253AA LONGHYPOTHETICAL PROTEIN (Pyrococcushorikoshii) |
PF02985(HEAT) | 5 | VAL A 33GLU A 31LEU A 24ALA A 27ARG A 63 | None | 1.15A | 5nd3B-2db0A:undetectable | 5nd3B-2db0A:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ghp | U4/U6SNRNA-ASSOCIATEDSPLICING FACTORPRP24 (Saccharomycescerevisiae) |
PF00076(RRM_1) | 5 | VAL A 165ASP A 164LEU A 178ARG A 268ARG A 134 | None | 1.26A | 5nd3B-2ghpA:undetectable | 5nd3B-2ghpA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gju | 252AA LONGHYPOTHETICAL PROTEIN (Pyrococcushorikoshii) |
no annotation | 5 | VAL A 53GLU A 52LEU A 99LEU A 46ARG A 232 | NoneNonePO4 A3005 (-4.5A)NoneNone | 1.14A | 5nd3B-2gjuA:undetectable | 5nd3B-2gjuA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gwn | DIHYDROOROTASE (Porphyromonasgingivalis) |
PF01979(Amidohydro_1) | 5 | GLU A 263LEU A 148ALA A 179THR A 102ARG A 112 | NoneKCX A 149 ( 3.7A)KCX A 149 ( 4.4A)NoneNone | 1.22A | 5nd3B-2gwnA:1.8 | 5nd3B-2gwnA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hun | 336AA LONGHYPOTHETICALDTDP-GLUCOSE4,6-DEHYDRATASE (Pyrococcushorikoshii) |
PF16363(GDP_Man_Dehyd) | 5 | VAL A 63HIS A 81LEU A 82ALA A 83THR A 127 | NAD A 801 (-3.7A)NoneNAD A 801 (-4.3A)NAD A 801 (-3.5A)NAD A 801 (-4.2A) | 1.12A | 5nd3B-2hunA:5.4 | 5nd3B-2hunA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isq | CYSTEINE SYNTHASE (Arabidopsisthaliana) |
PF00291(PALP) | 5 | VAL A 205GLU A 242LEU A 21ALA A 276ARG A 283 | None | 1.11A | 5nd3B-2isqA:undetectable | 5nd3B-2isqA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jg7 | ANTIQUITIN (Acanthopagrusschlegelii) |
PF00171(Aldedh) | 5 | VAL A 159ASP A 239LEU A 209ALA A 179PRO A 155 | None | 1.23A | 5nd3B-2jg7A:undetectable | 5nd3B-2jg7A:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogi | HYPOTHETICAL PROTEINSAG1661 (Streptococcusagalactiae) |
PF01966(HD) | 5 | VAL A 131ASP A 135LEU A 14LEU A 53ALA A 54 | None FE A 301 ( 2.5A)NoneNoneNone | 1.26A | 5nd3B-2ogiA:undetectable | 5nd3B-2ogiA:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qcv | PUTATIVE5-DEHYDRO-2-DEOXYGLUCONOKINASE (Bacillushalodurans) |
PF00294(PfkB) | 5 | VAL A 157LEU A 123ALA A 147THR A 98PRO A 46 | None | 1.26A | 5nd3B-2qcvA:6.6 | 5nd3B-2qcvA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vk2 | ABC TRANSPORTERPERIPLASMIC-BINDINGPROTEIN YTFQ (Escherichiacoli) |
PF13407(Peripla_BP_4) | 5 | VAL A 55LEU A 88LEU A 76ALA A 79THR A 103 | None | 1.20A | 5nd3B-2vk2A:2.5 | 5nd3B-2vk2A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vvg | KINESIN-2 (Giardiaintestinalis) |
PF00225(Kinesin) | 5 | LEU A 237HIS A 123LEU A 124ALA A 127SER A 130 | None | 0.87A | 5nd3B-2vvgA:undetectable | 5nd3B-2vvgA:23.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vwq | GLUCOSEDEHYDROGENASE (Haloferaxmediterranei) |
PF08240(ADH_N)PF16912(Glu_dehyd_C) | 5 | VAL A 299LEU A 192LEU A 159ALA A 162SER A 165 | None | 1.15A | 5nd3B-2vwqA:undetectable | 5nd3B-2vwqA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wnb | - (Sus scrofa) |
PF00777(Glyco_transf_29) | 5 | VAL A 242GLU A 200LEU A 217LEU A 209THR A 215 | None | 1.26A | 5nd3B-2wnbA:undetectable | 5nd3B-2wnbA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsx | L-CARNITINE/GAMMA-BUTYROBETAINEANTIPORTER (Escherichiacoli) |
PF02028(BCCT) | 5 | VAL A 352LEU A 297LEU A 145ALA A 148SER A 151 | None | 1.11A | 5nd3B-2wsxA:undetectable | 5nd3B-2wsxA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wvl | MANNOSYL-3-PHOSPHOGLYCERATE SYNTHASE (Thermusthermophilus) |
PF09488(Osmo_MPGsynth) | 5 | VAL A 176GLU A 251LEU A 99LEU A 73ARG A 65 | None ZN A1393 (-2.4A)NoneNoneNone | 1.19A | 5nd3B-2wvlA:undetectable | 5nd3B-2wvlA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x1c | ACYL-COENZYME (Penicilliumchrysogenum) |
PF03417(AAT) | 5 | ASP A 199LEU A 185ALA A 188SER A 191PRO A 194 | None | 1.18A | 5nd3B-2x1cA:undetectable | 5nd3B-2x1cA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z3t | CYTOCHROME P450 (Streptomycessp. TP-A0274) |
PF00067(p450) | 5 | LEU A 113HIS A 250LEU A 251ALA A 254THR A 114 | NoneHEM A 500 ( 4.8A)NoneHEM A 500 ( 3.4A)None | 1.16A | 5nd3B-2z3tA:undetectable | 5nd3B-2z3tA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zwv | PROBABLE RIBOSOMALRNA SMALL SUBUNITMETHYLTRANSFERASE (Thermusthermophilus) |
PF05175(MTS) | 5 | GLU A 73LEU A 3ALA A 77SER A 75ARG A 28 | None | 1.19A | 5nd3B-2zwvA:2.4 | 5nd3B-2zwvA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a1n | NDP-SUGAR EPIMERASE (Thermoplasmavolcanium) |
PF01370(Epimerase) | 5 | VAL A 48HIS A 68LEU A 69ALA A 70THR A 112 | NAD A3001 (-4.2A)NoneNAD A3001 (-4.6A)NAD A3001 (-3.3A)NAD A3001 ( 4.5A) | 1.19A | 5nd3B-3a1nA:5.7 | 5nd3B-3a1nA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a5v | ALPHA-GALACTOSIDASE (Umbelopsisvinacea) |
PF16499(Melibiase_2) | 5 | VAL A 293ASP A 296LEU A 313ALA A 263PRO A 301 | 1PG A 851 ( 4.5A)1PG A 851 (-4.3A)NoneNoneNone | 1.03A | 5nd3B-3a5vA:undetectable | 5nd3B-3a5vA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3euo | TYPE III PENTAKETIDESYNTHASE (Neurosporacrassa) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 5 | LEU A 282ALA A 303SER A 329THR A 278ARG A 160 | None | 1.18A | 5nd3B-3euoA:undetectable | 5nd3B-3euoA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fwt | MACROPHAGE MIGRATIONINHIBITORYFACTOR-LIKE PROTEIN (Leishmaniamajor) |
PF01187(MIF) | 5 | GLU A 29LEU A 19ALA A 22THR A 85ARG A 79 | None | 1.18A | 5nd3B-3fwtA:undetectable | 5nd3B-3fwtA:12.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hkz | DNA-DIRECTED RNAPOLYMERASE SUBUNITA'DNA-DIRECTED RNAPOLYMERASE SUBUNIT B (Sulfolobussolfataricus) |
PF00562(RNA_pol_Rpb2_6)PF00623(RNA_pol_Rpb1_2)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5)PF04983(RNA_pol_Rpb1_3)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 5 | VAL B 940ASP B 941LEU A 648ARG B 881PRO B 656 | None | 0.96A | 5nd3B-3hkzB:undetectable | 5nd3B-3hkzB:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ic6 | PUTATIVE METHYLASEFAMILY PROTEIN (Neisseriagonorrhoeae) |
PF00588(SpoU_methylase) | 5 | VAL A 93GLU A 91LEU A 151LEU A 96ALA A 99 | None | 1.18A | 5nd3B-3ic6A:undetectable | 5nd3B-3ic6A:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j9d | OUTER CAPSID PROTEINVP2 (Bluetonguevirus) |
PF00898(Orbi_VP2) | 5 | HIS A 658LEU A 631ALA A 656THR A 625ARG A 563 | None | 1.27A | 5nd3B-3j9dA:undetectable | 5nd3B-3j9dA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k5h | PHOSPHORIBOSYL-AMINOIMIDAZOLECARBOXYLASE (Aspergillusclavatus) |
PF01262(AlaDh_PNT_C)PF02222(ATP-grasp) | 5 | LEU A 170LEU A 145ALA A 180THR A 128ARG A 122 | None | 1.22A | 5nd3B-3k5hA:undetectable | 5nd3B-3k5hA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khf | MICROTUBULE-ASSOCIATEDSERINE/THREONINE-PROTEIN KINASE 3 (Homo sapiens) |
PF00595(PDZ) | 5 | VAL A 979LEU A1023HIS A 981LEU A 964ALA A 966 | None | 1.20A | 5nd3B-3khfA:undetectable | 5nd3B-3khfA:14.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m4a | PUTATIVE TYPE ITOPOISOMERASE (Deinococcusradiodurans) |
PF01028(Topoisom_I) | 5 | LEU A 195LEU A 126ALA A 125ARG A 216ARG A 121 | None | 1.27A | 5nd3B-3m4aA:undetectable | 5nd3B-3m4aA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n23 | SODIUM/POTASSIUM-TRANSPORTING ATPASESUBUNIT ALPHA-1 (Sus scrofa) |
PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF13246(Cation_ATPase) | 5 | VAL A 734ASP A 733ALA A 264SER A 268THR A 254 | None | 0.99A | 5nd3B-3n23A:2.1 | 5nd3B-3n23A:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nyi | FAT ACID-BINDINGPROTEIN (Eubacteriumventriosum) |
PF02645(DegV) | 5 | VAL A 272LEU A 17ALA A 9THR A 23PRO A 65 | STE A 301 ( 4.9A)NoneNoneNoneNone | 1.09A | 5nd3B-3nyiA:2.1 | 5nd3B-3nyiA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pvl | MYOSIN VIIA ISOFORM1 (Mus musculus) |
PF00784(MyTH4) | 5 | GLU A1248LEU A1212LEU A1231SER A1276ARG A1240 | None | 1.15A | 5nd3B-3pvlA:undetectable | 5nd3B-3pvlA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qk8 | ENOYL-COA HYDRATASEECHA15 (Mycobacteriummarinum) |
PF00378(ECH_1) | 5 | VAL A 33LEU A 235HIS A 38ALA A 117ARG A 85 | NoneNoneUNL A 291 ( 4.0A)UNL A 291 ( 3.3A)None | 1.08A | 5nd3B-3qk8A:undetectable | 5nd3B-3qk8A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qk8 | ENOYL-COA HYDRATASEECHA15 (Mycobacteriummarinum) |
PF00378(ECH_1) | 5 | VAL A 33LEU A 235HIS A 38SER A 67ARG A 85 | NoneNoneUNL A 291 ( 4.0A)NoneNone | 1.17A | 5nd3B-3qk8A:undetectable | 5nd3B-3qk8A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rd8 | FUMARATE HYDRATASECLASS II (Mycolicibacteriumsmegmatis) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | GLU A 306ALA A 400THR A 408ARG A 463ARG A 183 | None | 1.24A | 5nd3B-3rd8A:undetectable | 5nd3B-3rd8A:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s4w | FANCONI ANEMIA GROUPD2 PROTEIN HOMOLOG (Mus musculus) |
PF14631(FancD2) | 5 | VAL B 694LEU B 762LEU B 681ALA B 680PRO B 670 | None | 1.04A | 5nd3B-3s4wB:undetectable | 5nd3B-3s4wB:15.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t3o | METAL DEPENDENTHYDROLASE (Thermusthermophilus) |
PF07521(RMMBL)PF12706(Lactamase_B_2) | 5 | GLU A 292LEU A 304ALA A 262ARG A 266ARG A 286 | None | 1.13A | 5nd3B-3t3oA:undetectable | 5nd3B-3t3oA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tbh | O-ACETYL SERINESULFHYDRYLASE (Leishmaniadonovani) |
PF00291(PALP) | 5 | VAL A 210GLU A 247LEU A 27ALA A 281ARG A 288 | None | 1.27A | 5nd3B-3tbhA:undetectable | 5nd3B-3tbhA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tbh | O-ACETYL SERINESULFHYDRYLASE (Leishmaniadonovani) |
PF00291(PALP) | 5 | VAL A 210GLU A 247LEU A 39ALA A 281ARG A 288 | None | 1.19A | 5nd3B-3tbhA:undetectable | 5nd3B-3tbhA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3umm | PHOSPHORIBOSYLFORMYLGLYCINAMIDINESYNTHASE (Salmonellaenterica) |
PF02769(AIRS_C)PF13507(GATase_5) | 5 | VAL A1099GLU A 476LEU A 106ALA A 91ARG A 57 | None | 1.25A | 5nd3B-3ummA:undetectable | 5nd3B-3ummA:15.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v4o | MUCOSA-ASSOCIATEDLYMPHOID TISSUELYMPHOMATRANSLOCATIONPROTEIN 1 (Homo sapiens) |
PF00656(Peptidase_C14) | 5 | GLU A 500LEU A 372LEU A 515THR A 370PRO A 362 | None | 1.16A | 5nd3B-3v4oA:3.3 | 5nd3B-3v4oA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vps | NAD-DEPENDENTEPIMERASE/DEHYDRATASE (Streptomyceschartreusis) |
PF01370(Epimerase) | 5 | VAL A 59HIS A 75LEU A 76ALA A 77THR A 119 | NAD A 401 (-4.1A)NoneNAD A 401 (-4.2A)NAD A 401 (-3.6A)UD1 A 400 (-3.0A) | 1.10A | 5nd3B-3vpsA:6.4 | 5nd3B-3vpsA:23.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wt0 | CELL DIVISIONPROTEIN FTSA (Staphylococcusaureus) |
PF02491(SHS2_FTSA)PF14450(FtsA) | 5 | VAL A 211ASP A 210GLU A 229LEU A 76SER A 227 | ATP A 400 (-4.0A)NoneNoneNoneNone | 1.19A | 5nd3B-3wt0A:undetectable | 5nd3B-3wt0A:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cca | SYNTAXIN-BINDINGPROTEIN 2 (Homo sapiens) |
PF00995(Sec1) | 5 | ASP A 255GLU A 246LEU A 444ALA A 543SER A 545 | None | 1.24A | 5nd3B-4ccaA:undetectable | 5nd3B-4ccaA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cke | MRNA-CAPPING ENZYMEREGULATORY SUBUNIT (Vaccinia virus) |
PF03341(Pox_mRNA-cap) | 5 | ASP B 192HIS B 260LEU B 263SER B 188THR B 58 | None | 1.09A | 5nd3B-4ckeB:undetectable | 5nd3B-4ckeB:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ecn | LEUCINE-RICH REPEATPROTEIN (Bacteroidesthetaiotaomicron) |
PF14660(DUF4458) | 5 | VAL A 677ASP A 678LEU A 758ALA A 703THR A 759 | None | 1.26A | 5nd3B-4ecnA:undetectable | 5nd3B-4ecnA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eyo | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Rhodopseudomonaspalustris) |
PF13458(Peripla_BP_6) | 5 | VAL A 161ASP A 215LEU A 373LEU A 149THR A 375 | None | 1.20A | 5nd3B-4eyoA:undetectable | 5nd3B-4eyoA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fqd | NIKO PROTEIN (Streptomycestendae) |
PF00275(EPSP_synthase) | 5 | VAL A 147ASP A 146LEU A 200ALA A 199THR A 242 | None | 1.24A | 5nd3B-4fqdA:undetectable | 5nd3B-4fqdA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h53 | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 5 | ASP A 406GLU A 227LEU A 159SER A 180THR A 138 | SLB A 512 ( 4.1A)NoneNoneNoneNone | 1.23A | 5nd3B-4h53A:undetectable | 5nd3B-4h53A:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i1p | MUCOSA-ASSOCIATEDLYMPHOID TISSUELYMPHOMATRANSLOCATIONPROTEIN 1 (Homo sapiens) |
PF00656(Peptidase_C14) | 5 | GLU A 500LEU A 372LEU A 515THR A 370PRO A 362 | None | 1.20A | 5nd3B-4i1pA:undetectable | 5nd3B-4i1pA:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i8p | AMINOALDEHYDEDEHYDROGENASE 1 (Zea mays) |
PF00171(Aldedh) | 5 | VAL A 157ASP A 234LEU A 208ALA A 177PRO A 153 | None | 1.25A | 5nd3B-4i8pA:undetectable | 5nd3B-4i8pA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k22 | PROTEIN VISC (Escherichiacoli) |
PF01494(FAD_binding_3) | 5 | ASP A 5LEU A 135LEU A 32ALA A 30THR A 148 | None | 1.24A | 5nd3B-4k22A:undetectable | 5nd3B-4k22A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kws | D-MANNONATEDEHYDRATASE (Chromohalobactersalexigens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLU A 131LEU A 235ALA A 199ARG A 149ARG A 203 | None | 1.05A | 5nd3B-4kwsA:2.3 | 5nd3B-4kwsA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lk3 | UDP-GLUCURONIC ACIDDECARBOXYLASE 1 (Homo sapiens) |
PF16363(GDP_Man_Dehyd) | 5 | VAL A 145HIS A 158LEU A 159ALA A 160THR A 202 | NAD A 501 (-3.6A)NoneNAD A 501 (-4.4A)NAD A 501 (-3.9A)NAD A 501 (-4.0A) | 1.13A | 5nd3B-4lk3A:undetectable | 5nd3B-4lk3A:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lma | CYSTEINE SYNTHASE (Microcystisaeruginosa) |
PF00291(PALP) | 5 | VAL A 205GLU A 242LEU A 19ALA A 276ARG A 283 | None | 1.09A | 5nd3B-4lmaA:undetectable | 5nd3B-4lmaA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lmb | CYSTEINE SYNTHASE (Microcystisaeruginosa) |
PF00291(PALP) | 5 | VAL A 205GLU A 242LEU A 19ALA A 276ARG A 283 | None | 1.06A | 5nd3B-4lmbA:undetectable | 5nd3B-4lmbA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lmb | CYSTEINE SYNTHASE (Microcystisaeruginosa) |
PF00291(PALP) | 5 | VAL A 205GLU A 242LEU A 274ALA A 276ARG A 283 | None | 1.02A | 5nd3B-4lmbA:undetectable | 5nd3B-4lmbA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2c | CRISPR-ASSOCIATEDHELICASE CAS3 (Thermobaculumterrenum) |
PF00271(Helicase_C) | 5 | VAL A 317GLU A 316LEU A 296LEU A 339ALA A 314 | None | 1.20A | 5nd3B-4q2cA:undetectable | 5nd3B-4q2cA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tuf | MAJOR EXTRACELLULARENDOGLUCANASE (Xanthomonascampestris) |
PF00150(Cellulase) | 5 | ASP A 134GLU A 303LEU A 249LEU A 258ALA A 259 | None | 1.15A | 5nd3B-4tufA:undetectable | 5nd3B-4tufA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uul | L-LACTATEDEHYDROGENASE (Trichomonasvaginalis) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | GLU A 323LEU A 331ALA A 327THR A 111PRO A 131 | None | 1.21A | 5nd3B-4uulA:5.6 | 5nd3B-4uulA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w6q | GLUCOSYLTRANSFERASE (Streptococcusagalactiae) |
no annotation | 5 | VAL A 126ASP A 125LEU A 319ALA A 323THR A 25 | None | 1.13A | 5nd3B-4w6qA:undetectable | 5nd3B-4w6qA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wis | LIPID SCRAMBLASE ([Nectria]haematococca) |
PF04547(Anoctamin) | 5 | VAL A 500ASP A 499LEU A 565SER A 184THR A 563 | None | 1.14A | 5nd3B-4wisA:undetectable | 5nd3B-4wisA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5af7 | ACYL-COADEHYDROGENASE (Advenellamimigardefordensis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | VAL A 87ASP A 88LEU A 372ALA A 250THR A 368 | NoneGOL A 510 ( 4.6A)NoneNoneFAD A 410 (-2.8A) | 1.13A | 5nd3B-5af7A:undetectable | 5nd3B-5af7A:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b01 | MOEN5 (Streptomycesviridosporus) |
no annotation | 5 | ASP A 10LEU A 68LEU A 32ALA A 30ARG A 90 | None | 1.24A | 5nd3B-5b01A:undetectable | 5nd3B-5b01A:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5csl | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF00289(Biotin_carb_N)PF00364(Biotin_lipoyl)PF01039(Carboxyl_trans)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2)PF08326(ACC_central) | 5 | VAL A2003ASP A2004LEU A1950ALA A1951ARG A2125 | None | 1.14A | 5nd3B-5cslA:3.3 | 5nd3B-5cslA:12.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dgt | BENZOYLFORMATEDECARBOXYLASE (Pseudomonasputida) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | VAL A 211ASP A 210LEU A 197LEU A 223ALA A 322 | None | 1.28A | 5nd3B-5dgtA:2.4 | 5nd3B-5dgtA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k9o | HEMAGGLUTININ (Influenza Avirus) |
PF00509(Hemagglutinin) | 5 | GLU F 89LEU F 71ALA F 67ARG F 229ARG F 109 | None | 1.24A | 5nd3B-5k9oF:undetectable | 5nd3B-5k9oF:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lb3 | ATP-DEPENDENT DNAHELICASE Q5 (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C)PF16124(RecQ_Zn_bind) | 5 | VAL B 203ASP B 202LEU B 191ALA B 159THR B 54 | NoneNoneNoneNoneADP B 502 (-4.1A) | 1.24A | 5nd3B-5lb3B:undetectable | 5nd3B-5lb3B:20.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mjs | TUBULIN BETA CHAIN (Schizosaccharomycespombe) |
no annotation | 6 | ASP A 26GLU A 27LEU A 215HIS A 227ARG A 317PRO A 357 | None | 1.16A | 5nd3B-5mjsA:55.5 | 5nd3B-5mjsA:59.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mjs | TUBULIN BETA CHAIN (Schizosaccharomycespombe) |
no annotation | 6 | ASP A 26GLU A 27LEU A 215HIS A 227LEU A 228PRO A 357 | None | 1.02A | 5nd3B-5mjsA:55.5 | 5nd3B-5mjsA:59.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mjs | TUBULIN BETA CHAIN (Schizosaccharomycespombe) |
no annotation | 6 | ASP A 26GLU A 27LEU A 215LEU A 228ALA A 231PRO A 357 | None | 1.16A | 5nd3B-5mjsA:55.5 | 5nd3B-5mjsA:59.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 8 | VAL B 23ASP B 26GLU B 27LEU B 217HIS B 229LEU B 230THR B 276ARG B 320 | None | 1.25A | 5nd3B-5n5nB:55.8 | 5nd3B-5n5nB:97.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 8 | VAL B 23ASP B 26GLU B 27LEU B 217HIS B 229SER B 236THR B 276ARG B 320 | None | 1.23A | 5nd3B-5n5nB:55.8 | 5nd3B-5n5nB:97.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 9 | VAL B 23GLU B 27LEU B 217HIS B 229ALA B 233SER B 236THR B 276ARG B 320PRO B 360 | None | 1.04A | 5nd3B-5n5nB:55.8 | 5nd3B-5n5nB:97.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 9 | VAL B 23GLU B 27LEU B 217HIS B 229LEU B 230ALA B 233THR B 276ARG B 320PRO B 360 | None | 1.05A | 5nd3B-5n5nB:55.8 | 5nd3B-5n5nB:97.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o9h | C5A ANAPHYLATOXINCHEMOTACTIC RECEPTOR1 (Homo sapiens) |
no annotation | 5 | VAL A 58LEU A 127ALA A 79THR A 129ARG A 134 | NoneNoneNone9P2 A 401 (-4.4A)None | 1.22A | 5nd3B-5o9hA:undetectable | 5nd3B-5o9hA:11.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tr1 | CHLORIDE CHANNELPROTEIN (Bos taurus) |
PF00654(Voltage_CLC) | 5 | GLU A 490LEU A 56ALA A 210THR A 54ARG A 238 | NoneNoneNoneNoneY01 A 701 (-4.1A) | 0.99A | 5nd3B-5tr1A:undetectable | 5nd3B-5tr1A:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tr1 | CHLORIDE CHANNELPROTEIN (Bos taurus) |
PF00654(Voltage_CLC) | 5 | GLU A 490LEU A 56THR A 54ARG A 238PRO A 216 | NoneNoneNoneY01 A 701 (-4.1A)None | 1.15A | 5nd3B-5tr1A:undetectable | 5nd3B-5tr1A:20.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w3f | TUBULIN ALPHA-1CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 6 | GLU A 27LEU A 218LEU A 231SER A 237ARG A 321PRO A 361 | None | 1.19A | 5nd3B-5w3fA:55.3 | 5nd3B-5w3fA:42.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w3j | TUBULIN BETA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 7 | VAL B 23ASP B 26GLU B 27LEU B 215LEU B 228THR B 274ARG B 318 | TA1 B 502 (-3.9A)TA1 B 502 (-4.1A)TA1 B 502 (-3.6A)NoneNoneTA1 B 502 (-4.7A)None | 1.19A | 5nd3B-5w3jB:56.2 | 5nd3B-5w3jB:75.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w3j | TUBULIN BETA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 7 | VAL B 23ASP B 26GLU B 27LEU B 215SER B 234ARG B 318PRO B 358 | TA1 B 502 (-3.9A)TA1 B 502 (-4.1A)TA1 B 502 (-3.6A)NoneTA1 B 502 ( 4.9A)NoneNone | 1.17A | 5nd3B-5w3jB:56.2 | 5nd3B-5w3jB:75.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w3j | TUBULIN BETA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 7 | VAL B 23ASP B 26GLU B 27LEU B 215THR B 274ARG B 318PRO B 358 | TA1 B 502 (-3.9A)TA1 B 502 (-4.1A)TA1 B 502 (-3.6A)NoneTA1 B 502 (-4.7A)NoneNone | 1.22A | 5nd3B-5w3jB:56.2 | 5nd3B-5w3jB:75.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wql | TAIL-SPECIFICPROTEASE (Escherichiacoli) |
no annotation | 5 | VAL C 469LEU C 392ALA C 458ARG C 448ARG C 513 | None | 1.28A | 5nd3B-5wqlC:2.0 | 5nd3B-5wqlC:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wyb | PROBABLE ENOYL-COAHYDRATASE/ISOMERASE (Pseudomonasaeruginosa) |
no annotation | 5 | VAL B 195ASP B 196GLU B 137LEU B 206ALA B 203 | NoneNoneNoneNoneACT B 302 ( 4.4A) | 1.25A | 5nd3B-5wybB:undetectable | 5nd3B-5wybB:11.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtc | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN2NADH-UBIQUINONEOXIDOREDUCTASE CHAIN4L (Homo sapiens) |
no annotation | 5 | GLU i 34LEU k 26LEU i 61ALA i 64SER i 67 | None | 1.23A | 5nd3B-5xtci:undetectable | 5nd3B-5xtci:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y7o | UGGT (Thermomycesdupontii) |
PF06427(UDP-g_GGTase) | 5 | LEU A 73LEU A 49ALA A 53ARG A 67ARG A 177 | None | 1.20A | 5nd3B-5y7oA:undetectable | 5nd3B-5y7oA:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zbh | NEUROPEPTIDE YRECEPTOR TYPE 1,T4LYSOZYME,NEUROPEPTIDE Y RECEPTOR TYPE 1 (Escherichiavirus T4;Homo sapiens) |
no annotation | 5 | LEU A1014LEU A1012THR A1058ARG A 241PRO A 145 | None | 1.23A | 5nd3B-5zbhA:undetectable | 5nd3B-5zbhA:13.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b2y | SOLUTE-BINDINGPERIPLASMIC PROTEINOF IRON/SIDEROPHOREABC TRANSPORTER (Yersinia pestis) |
no annotation | 5 | VAL A 3LEU A 27LEU A 141ALA A 144PRO A 120 | None | 1.22A | 5nd3B-6b2yA:undetectable | 5nd3B-6b2yA:22.16 |