SIMILAR PATTERNS OF AMINO ACIDS FOR 5N8J_E_DVAE7

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bol PROTEIN
(RIBONUCLEASE RH)

(Rhizopus niveus) 		PF00445
(Ribonuclease_T2) 		3 TYR A  84
SER A  74
TRP A 102
 None
 0.87A 5n8jB-1bolA:
0.0		 5n8jB-1bolA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfe PATHOGENESIS-RELATED
PROTEIN P14A

(Solanum
lycopersicum) 		PF00188
(CAP) 		3 TYR A   7
SER A 120
TRP A  25
 None
 0.76A 5n8jB-1cfeA:
undetectable		 5n8jB-1cfeA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ept PORCINE E-TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		3 TYR C 217
SER C 171
TRP C 215
 None
 0.90A 5n8jB-1eptC:
0.0		 5n8jB-1eptC:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1etz FAB NC10.14 - HEAVY
CHAIN

(Mus musculus) 		no annotation 3 TYR H 111
SER H 103
TRP H  54
 GAS  H 229 (-3.5A)
None
GAS  H 229 ( 4.3A)
 0.83A 5n8jB-1etzH:
0.0		 5n8jB-1etzH:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		3 TYR A 126
SER A 199
TRP A 471
 None
None
EDO  A1713 ( 3.6A)
 0.97A 5n8jB-1gqjA:
undetectable		 5n8jB-1gqjA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		3 TYR E 217
SER E 171
TRP E 215
 None
 0.84A 5n8jB-1h9hE:
0.0		 5n8jB-1h9hE:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		3 TYR A  78
SER A  76
TRP A 220
 None
 1.04A 5n8jB-1k72A:
0.0		 5n8jB-1k72A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kho ALPHA-TOXIN

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		3 TYR A 235
SER A 233
TRP A 188
 None
 1.02A 5n8jB-1khoA:
0.0		 5n8jB-1khoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		3 TYR A 161
SER A 163
TRP A  64
 None
 1.07A 5n8jB-1l5aA:
0.0		 5n8jB-1l5aA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbq TRYPSIN

(Oncorhynchus
keta) 		PF00089
(Trypsin) 		3 TYR A 217
SER A 171
TRP A 215
 None
 0.96A 5n8jB-1mbqA:
undetectable		 5n8jB-1mbqA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		3 TYR A 116
SER A 189
TRP A 470
 GOL  A 751 (-4.8A)
None
GOL  A 751 (-3.6A)
 1.00A 5n8jB-1mqqA:
undetectable		 5n8jB-1mqqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ouo NUCLEASE

(Vibrio
vulnificus) 		PF04231
(Endonuclease_1) 		3 TYR A  35
SER A  41
TRP A  78
 None
 0.76A 5n8jB-1ouoA:
undetectable		 5n8jB-1ouoA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 TYR A  99
SER A  97
TRP A 398
 None
 1.05A 5n8jB-1p2zA:
undetectable		 5n8jB-1p2zA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 TYR A 129
SER A 280
TRP A 160
 None
 1.05A 5n8jB-1qorA:
undetectable		 5n8jB-1qorA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0f ENDO-ALPHA-SIALIDASE

(Enterobacteria
phage K1F) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		3 TYR A 592
SER A 610
TRP A 678
 TYR  A 592 ( 1.3A)
SER  A 610 ( 0.0A)
TRP  A 678 ( 0.5A)
 0.98A 5n8jB-1v0fA:
undetectable		 5n8jB-1v0fA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v29 NITRILE HYDRATASE A
CHAIN
NITRILE HYDRATASE B
CHAIN

(Bacillus
smithii;
Bacillus
smithii) 		PF02979
(NHase_alpha)
PF02211
(NHase_beta) 		3 TYR B 164
SER A 145
TRP B 207
 None
 0.78A 5n8jB-1v29B:
undetectable		 5n8jB-1v29B:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 TYR A 358
SER A 278
TRP A 165
 None
 0.93A 5n8jB-1w1kA:
undetectable		 5n8jB-1w1kA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3b GLUCOSE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF01547
(SBP_bac_1) 		3 TYR A 329
SER A 314
TRP A 125
 None
 0.85A 5n8jB-2b3bA:
undetectable		 5n8jB-2b3bA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		3 TYR A 222
SER A 122
TRP A 228
 None
 0.61A 5n8jB-2bihA:
undetectable		 5n8jB-2bihA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bii NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		3 TYR A 222
SER A 122
TRP A 228
 None
 0.54A 5n8jB-2biiA:
undetectable		 5n8jB-2biiA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb4 MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		no annotation 3 TYR A 215
SER A 293
TRP A  98
 None
 1.03A 5n8jB-2cb4A:
undetectable		 5n8jB-2cb4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9y CARBAMATE KINASE

(Aeropyrum
pernix) 		PF00696
(AA_kinase) 		3 TYR A  61
SER A  63
TRP A  88
 None
 0.92A 5n8jB-2e9yA:
undetectable		 5n8jB-2e9yA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7e ENDONUCLEASE I

(Vibrio cholerae) 		PF04231
(Endonuclease_1) 		3 TYR A  35
SER A  41
TRP A  78
 None
CL  A 300 (-3.1A)
None
 0.74A 5n8jB-2g7eA:
undetectable		 5n8jB-2g7eA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 TYR A 780
SER A 778
TRP A 797
 None
 0.98A 5n8jB-2ivfA:
undetectable		 5n8jB-2ivfA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jep XYLOGLUCANASE

(Paenibacillus
pabuli) 		PF00150
(Cellulase) 		3 TYR A 266
SER A 326
TRP A 269
 EDO  A1396 (-3.9A)
None
None
 1.08A 5n8jB-2jepA:
undetectable		 5n8jB-2jepA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pu3 ENDONUCLEASE I

(Aliivibrio
salmonicida) 		PF04231
(Endonuclease_1) 		3 TYR A  35
SER A  41
TRP A  78
 None
CL  A 301 (-3.1A)
None
 0.74A 5n8jB-2pu3A:
undetectable		 5n8jB-2pu3A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		3 TYR A 469
SER A 472
TRP A 127
 None
 1.00A 5n8jB-2pyxA:
undetectable		 5n8jB-2pyxA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnu UNCHARACTERIZED
PROTEIN PA0076

(Pseudomonas
aeruginosa) 		PF09867
(DUF2094) 		3 TYR A  86
SER A  79
TRP A  48
 None
MLZ  A   9 ( 2.6A)
None
 1.07A 5n8jB-2qnuA:
undetectable		 5n8jB-2qnuA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxl HEAT SHOCK PROTEIN
HOMOLOG SSE1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		3 TYR A 404
SER A 444
TRP A 462
 None
 1.06A 5n8jB-2qxlA:
undetectable		 5n8jB-2qxlA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjh PHYCOERYTHRIN ALPHA
CHAIN
PHYCOERYTHRIN BETA
SUBUNIT

(Gloeobacter
violaceus;
Gloeobacter
violaceus) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		3 TYR A  95
SER B  11
TRP A 108
 None
 0.74A 5n8jB-2vjhA:
undetectable		 5n8jB-2vjhA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2n VIRGINIAMYCIN B
LYASE

(Staphylococcus
aureus) 		no annotation 3 TYR A 134
SER A 170
TRP A 113
 None
None
CL  A 300 (-4.4A)
 0.98A 5n8jB-2z2nA:
undetectable		 5n8jB-2z2nA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3by9 SENSOR PROTEIN

(Vibrio cholerae) 		PF02743
(dCache_1) 		3 TYR A 264
SER A 190
TRP A 209
 None
 0.90A 5n8jB-3by9A:
undetectable		 5n8jB-3by9A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4q PREDICTED
GLYCOSYLTRANSFERASES

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		3 TYR A  27
SER A 194
TRP A 391
 None
 1.03A 5n8jB-3c4qA:
undetectable		 5n8jB-3c4qA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		3 TYR B 446
SER B 328
TRP B 337
 None
 0.75A 5n8jB-3egwB:
undetectable		 5n8jB-3egwB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5a FMN
ADENYLYLTRANSFERASE

([Candida]
glabrata) 		PF01507
(PAPS_reduct) 		3 TYR A 216
SER A 222
TRP A 202
 APC  A 305 (-4.7A)
APC  A 305 (-2.5A)
None
 0.98A 5n8jB-3g5aA:
undetectable		 5n8jB-3g5aA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 TYR B 127
SER B  83
TRP B 210
 None
 0.92A 5n8jB-3hhsB:
undetectable		 5n8jB-3hhsB:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igq GLR4197 PROTEIN

(Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		3 TYR A 102
SER A  44
TRP A  47
 ACY  A 701 ( 4.8A)
None
None
 0.99A 5n8jB-3igqA:
undetectable		 5n8jB-3igqA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
mutans) 		PF01791
(DeoC) 		3 TYR A   8
SER A 327
TRP A 322
 None
 0.97A 5n8jB-3iv3A:
undetectable		 5n8jB-3iv3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Lactobacillus
brevis) 		PF13407
(Peripla_BP_4) 		3 TYR A 223
SER A 221
TRP A 252
 None
 0.96A 5n8jB-3jy6A:
undetectable		 5n8jB-3jy6A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9x D-XYLOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		3 TYR A  89
SER A 103
TRP A  17
 None
 0.95A 5n8jB-3m9xA:
undetectable		 5n8jB-3m9xA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE

(Bacteroides
ovatus) 		no annotation 3 TYR A 256
SER A 224
TRP A 367
 None
 0.86A 5n8jB-3n6zA:
undetectable		 5n8jB-3n6zA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Mycobacteroides
abscessus) 		PF01259
(SAICAR_synt) 		3 TYR A 105
SER A 133
TRP A 224
 TYR  A 105 ( 1.3A)
SER  A 133 ( 0.0A)
TRP  A 224 ( 0.5A)
 0.80A 5n8jB-3r9rA:
undetectable		 5n8jB-3r9rA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryl PROTEIN VPA1370

(Vibrio
parahaemolyticus) 		no annotation 3 TYR A 307
SER A 386
TRP A 284
 None
 0.99A 5n8jB-3rylA:
undetectable		 5n8jB-3rylA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vib MTRR

(Neisseria
gonorrhoeae) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		3 TYR A 106
SER A 101
TRP A 177
 None
 1.05A 5n8jB-3vibA:
undetectable		 5n8jB-3vibA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2l TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		3 TYR A 250
SER A 293
TRP A 229
 None
 0.85A 5n8jB-4a2lA:
undetectable		 5n8jB-4a2lA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axn CHITINASE C1

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		3 TYR A  59
SER A 301
TRP A 317
 None
 1.04A 5n8jB-4axnA:
undetectable		 5n8jB-4axnA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzg ALDOSE 1-EPIMERASE

(Bacillus
subtilis) 		PF01263
(Aldose_epim) 		3 TYR A 259
SER A 317
TRP A 268
 None
 0.88A 5n8jB-4bzgA:
2.4		 5n8jB-4bzgA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		3 TYR A 298
SER A 296
TRP A 315
 None
 1.08A 5n8jB-4ccdA:
2.0		 5n8jB-4ccdA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drr OUTER CAPSID PROTEIN
VP4

(Rotavirus sp.) 		no annotation 3 TYR A 175
SER A 187
TRP A  81
 None
 0.74A 5n8jB-4drrA:
undetectable		 5n8jB-4drrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqh CAPSID PROTEIN

(Tobacco mosaic
virus) 		PF00721
(TMV_coat) 		3 TYR A 139
SER A 148
TRP A  17
 None
 1.04A 5n8jB-4gqhA:
undetectable		 5n8jB-4gqhA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		3 TYR A 429
SER A 433
TRP A  34
 None
GOL  A 503 ( 4.6A)
None
 1.06A 5n8jB-4ha4A:
undetectable		 5n8jB-4ha4A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		3 TYR A1206
SER A1218
TRP A1221
 None
 0.88A 5n8jB-4iglA:
0.3		 5n8jB-4iglA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A   9
SER A 359
TRP A  46
 None
None
IOD  A 401 (-4.8A)
 0.88A 5n8jB-4izgA:
undetectable		 5n8jB-4izgA:
18.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jo6 STREPTAVIDIN

(Streptomyces
avidinii) 		PF01382
(Avidin) 		3 TYR A  43
SER A  45
TRP A  79
 None
 0.41A 5n8jB-4jo6A:
23.2		 5n8jB-4jo6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1

(Rattus
norvegicus) 		PF00777
(Glyco_transf_29) 		3 TYR A 278
SER A 280
TRP A 162
 None
 0.83A 5n8jB-4mpsA:
undetectable		 5n8jB-4mpsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		3 TYR A 955
SER A 960
TRP A 860
 None
 0.78A 5n8jB-4o9xA:
undetectable		 5n8jB-4o9xA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy7 PUTATIVE SECRETED
CELLULOSE BINDING
PROTEIN

(Streptomyces
coelicolor) 		PF03067
(LPMO_10) 		3 TYR A 116
SER A 114
TRP A 123
 None
 0.87A 5n8jB-4oy7A:
undetectable		 5n8jB-4oy7A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdd 3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE

(Rhodococcus
rhodochrous) 		PF00355
(Rieske) 		3 TYR A 239
SER A 243
TRP A 339
 None
 1.02A 5n8jB-4qddA:
undetectable		 5n8jB-4qddA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 TYR A 523
SER A 675
TRP A 726
 None
 1.06A 5n8jB-4rbnA:
undetectable		 5n8jB-4rbnA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 TYR A1281
SER A1286
TRP A1349
 None
 0.98A 5n8jB-4rh7A:
undetectable		 5n8jB-4rh7A:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryi INTEGRAL MEMBRANE
PROTEIN

(Bacillus cereus) 		PF03073
(TspO_MBR) 		3 TYR A 144
SER A 146
TRP A  40
 None
PKA  A 201 ( 4.4A)
None
 1.03A 5n8jB-4ryiA:
undetectable		 5n8jB-4ryiA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		3 TYR A  61
SER A  59
TRP A   9
 None
 1.00A 5n8jB-4upiA:
undetectable		 5n8jB-4upiA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		3 TYR A 154
SER A 116
TRP A 131
 None
 0.97A 5n8jB-4uw2A:
undetectable		 5n8jB-4uw2A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w9u ACYL-COA
DEHYDROGENASE

(Brucella
abortus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 TYR A 114
SER A 240
TRP A 182
 None
 0.87A 5n8jB-4w9uA:
undetectable		 5n8jB-4w9uA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh3 N-ACETYLHEXOSAMINE
1-KINASE

(Bifidobacterium
longum) 		PF01636
(APH) 		3 TYR A  36
SER A   4
TRP A  99
 None
 0.90A 5n8jB-4wh3A:
undetectable		 5n8jB-4wh3A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN

(Homo sapiens;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		3 TYR A 102
SER A  44
TRP A  47
 None
 0.83A 5n8jB-4x5tA:
undetectable		 5n8jB-4x5tA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8k RNA POLYMERASE SIGMA
FACTOR SIGA
RNA
POLYMERASE-BINDING
PROTEIN RBPA

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF00140
(Sigma70_r1_2)
PF04542
(Sigma70_r2)
PF13397
(RbpA) 		3 TYR A 258
SER B  90
TRP B  82
 None
 1.08A 5n8jB-4x8kA:
undetectable		 5n8jB-4x8kA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		3 TYR A 112
SER A 126
TRP A  40
 None
 1.06A 5n8jB-4ywhA:
undetectable		 5n8jB-4ywhA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		3 TYR A 341
SER A 319
TRP A 122
 None
 1.08A 5n8jB-4z2aA:
undetectable		 5n8jB-4z2aA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		3 TYR A1934
SER A1913
TRP A2036
 None
 0.74A 5n8jB-5a22A:
undetectable		 5n8jB-5a22A:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		3 TYR A 234
SER A 275
TRP A 592
 None
 0.98A 5n8jB-5a2rA:
undetectable		 5n8jB-5a2rA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 TYR A 737
SER A 683
TRP A 694
 None
 0.84A 5n8jB-5a7mA:
undetectable		 5n8jB-5a7mA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb7 OUTER CAPSID PROTEIN
VP4

(Rotavirus A) 		no annotation 3 TYR A 175
SER A 187
TRP A  81
 None
 0.71A 5n8jB-5cb7A:
undetectable		 5n8jB-5cb7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 TYR A  84
SER A 608
TRP A 614
 None
 0.93A 5n8jB-5dmyA:
undetectable		 5n8jB-5dmyA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dum 65C6 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H  57
SER H  56
TRP H  33
 None
 1.06A 5n8jB-5dumH:
undetectable		 5n8jB-5dumH:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4m HYDROXYNITRILE LYASE

(Davallia
tyermannii) 		no annotation 3 TYR A  99
SER A 122
TRP A  35
 None
 0.77A 5n8jB-5e4mA:
undetectable		 5n8jB-5e4mA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7g IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		no annotation 3 TYR A 466
SER A 368
TRP A 364
 XYS  A 504 ( 3.1A)
None
BGC  A 507 (-3.2A)
 1.02A 5n8jB-5e7gA:
undetectable		 5n8jB-5e7gA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7h IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		PF01833
(TIG) 		3 TYR A 466
SER A 368
TRP A 364
 None
 1.03A 5n8jB-5e7hA:
undetectable		 5n8jB-5e7hA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai PORTAL PROTEIN

(Salmonella
virus P22) 		PF16510
(P22_portal) 		3 TYR A  48
SER A  46
TRP A  41
 None
 1.03A 5n8jB-5gaiA:
undetectable		 5n8jB-5gaiA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		3 TYR A 334
SER A 347
TRP A 289
 None
 1.06A 5n8jB-5gslA:
undetectable		 5n8jB-5gslA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzh ENDO-BETA-1,2-GLUCAN
ASE

(Chitinophaga
pinensis) 		PF10091
(Glycoamylase) 		3 TYR A 183
SER A 181
TRP A 200
 None
None
IOD  A 509 ( 4.9A)
 1.03A 5n8jB-5gzhA:
undetectable		 5n8jB-5gzhA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiy NON-STRUCTURAL
PROTEIN 9

(Porcine
epidemic
diarrhea virus) 		PF08710
(nsp9) 		3 TYR A  29
SER A  13
TRP A  53
 None
 1.04A 5n8jB-5hiyA:
undetectable		 5n8jB-5hiyA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1u GERMACRADIEN-4-OL
SYNTHASE

(Streptomyces
citricolor) 		no annotation 3 TYR A 303
SER A 215
TRP A 299
 None
 1.08A 5n8jB-5i1uA:
undetectable		 5n8jB-5i1uA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		3 TYR A 508
SER A 496
TRP A 537
 None
 0.94A 5n8jB-5j44A:
undetectable		 5n8jB-5j44A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjo UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08238
(Sel1) 		3 TYR A  88
SER A  86
TRP A  92
 None
 1.03A 5n8jB-5jjoA:
undetectable		 5n8jB-5jjoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnp PROBABLE CELLULOSE
SYNTHASE A CATALYTIC
SUBUNIT 8
[UDP-FORMING]

(Oryza sativa) 		PF03552
(Cellulose_synt) 		3 TYR A 433
SER A 435
TRP A 416
 None
 1.05A 5n8jB-5jnpA:
undetectable		 5n8jB-5jnpA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2x DNA-DIRECTED
PRIMASE/POLYMERASE
PROTEIN

(Homo sapiens) 		no annotation 3 TYR A 293
SER A 295
TRP A  87
 None
 1.02A 5n8jB-5l2xA:
undetectable		 5n8jB-5l2xA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens;
Homo sapiens) 		no annotation
PF04858
(TH1) 		3 TYR B 238
SER B 277
TRP A  24
 None
 0.86A 5n8jB-5l3xB:
undetectable		 5n8jB-5l3xB:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Mus musculus;
Gloeobacter
violaceus) 		no annotation 3 TYR A 101
SER A  43
TRP A  46
 None
 0.90A 5n8jB-5osbA:
undetectable		 5n8jB-5osbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swn FLUOROACETATE
DEHALOGENASE

(Rhodopseudomonas
palustris) 		PF00561
(Abhydrolase_1) 		3 TYR A 117
SER A 116
TRP A 264
 None
 0.95A 5n8jB-5swnA:
undetectable		 5n8jB-5swnA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacterium
smegmatis) 		PF01261
(AP_endonuc_2) 		3 TYR A 282
SER A 284
TRP A 137
 None
 0.70A 5n8jB-5tnvA:
undetectable		 5n8jB-5tnvA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans) 		PF03639
(Glyco_hydro_81) 		3 TYR A 176
SER A  99
TRP A  80
 None
 0.93A 5n8jB-5v1wA:
1.4		 5n8jB-5v1wA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 3 TYR C 102
SER C  44
TRP C  47
 None
 0.91A 5n8jB-5v6nC:
undetectable		 5n8jB-5v6nC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veh KYNURENINE
AMINOTRANSFERASE

(Aedes aegypti) 		no annotation 3 TYR A 268
SER A  87
TRP A 244
 None
 0.75A 5n8jB-5vehA:
undetectable		 5n8jB-5vehA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veh KYNURENINE
AMINOTRANSFERASE

(Aedes aegypti) 		no annotation 3 TYR A 268
SER A  91
TRP A 244
 None
 1.07A 5n8jB-5vehA:
undetectable		 5n8jB-5vehA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9j PRHC

(Penicillium
brasilianum) 		no annotation 3 TYR A 104
SER A  96
TRP A  63
 None
 0.91A 5n8jB-5x9jA:
2.1		 5n8jB-5x9jA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbf UNCONVENTIONAL
MYOSIN-VIIB

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4) 		3 TYR A2085
SER A2082
TRP A1869
 None
 1.03A 5n8jB-5xbfA:
undetectable		 5n8jB-5xbfA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y33 ALGINATE LYASE

(Flavobacterium
sp. UMI-01) 		no annotation 3 TYR A 115
SER A 108
TRP A 150
 None
 0.76A 5n8jB-5y33A:
undetectable		 5n8jB-5y33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 3 TYR A 452
SER A 450
TRP A 471
 None
 0.96A 5n8jB-5z06A:
undetectable		 5n8jB-5z06A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE

(Bacillus
licheniformis) 		no annotation 3 TYR A  82
SER A  76
TRP A 111
 None
 1.01A 5n8jB-6b7kA:
undetectable		 5n8jB-6b7kA:
undetectable