SIMILAR PATTERNS OF AMINO ACIDS FOR 5N5D_B_SAMB303_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7j PHOSPHORIBULOKINASE

(Rhodobacter
sphaeroides) 		PF00485
(PRK) 		4 GLY A  41
SER A  14
ARG A  94
ASP A  42
 None
 0.98A 5n5dB-1a7jA:
undetectable		 5n5dB-1a7jA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhe POLYGALACTURONASE

(Pectobacterium
carotovorum) 		PF00295
(Glyco_hydro_28) 		4 GLY A 184
PHE A 185
SER A 209
ASN A 110
 None
 1.10A 5n5dB-1bheA:
undetectable		 5n5dB-1bheA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5y ROB TRANSCRIPTION
FACTOR

(Escherichia
coli) 		PF06445
(GyrI-like)
PF12833
(HTH_18) 		4 GLY A 235
PHE A 239
SER A 153
ASN A 278
 None
 1.05A 5n5dB-1d5yA:
undetectable		 5n5dB-1d5yA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLY A  27
PHE A 528
GLU A 511
ARG A 132
 None
 1.08A 5n5dB-1fepA:
undetectable		 5n5dB-1fepA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h32 CYTOCHROME C

(Rhodovulum
sulfidophilum) 		PF00034
(Cytochrom_C) 		4 GLY B 124
GLU B   2
ARG B 118
ASP B 128
 None
 1.03A 5n5dB-1h32B:
undetectable		 5n5dB-1h32B:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8g HYPOTHETICAL PROTEIN
YBDK

(Escherichia
coli) 		PF04107
(GCS2) 		4 GLY A 134
PHE A 133
GLU A  19
ASP A 242
 None
 1.02A 5n5dB-1r8gA:
undetectable		 5n5dB-1r8gA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt4 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF04107
(GCS2) 		4 GLY A 134
PHE A 133
GLU A  19
ASP A 242
 None
 1.05A 5n5dB-1tt4A:
undetectable		 5n5dB-1tt4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udq RIBONUCLEASE PH

(Aquifex
aeolicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 GLY A 123
SER A 163
ARG A  68
ASP A 180
 PO4  A 701 (-3.6A)
None
None
None
 0.82A 5n5dB-1udqA:
undetectable		 5n5dB-1udqA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE

(Sulfolobus
solfataricus) 		PF00701
(DHDPS) 		4 GLY A  95
PHE A  71
SER A 123
ASN A  67
 None
None
GOL  A1297 ( 4.8A)
None
 0.98A 5n5dB-1w3iA:
undetectable		 5n5dB-1w3iA:
23.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2avd CATECHOL-O-METHYLTRA
NSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		5 GLY A 110
PHE A 112
SER A 116
GLU A 134
ASP A 185
 SAM  A 501 (-3.4A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.0A)
SAM  A 501 (-2.9A)
SAM  A 501 (-3.4A)
 0.25A 5n5dB-2avdA:
28.6		 5n5dB-2avdA:
34.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1l RESTRICTION
ENDONUCLEASE

(Bacillus firmus) 		PF13091
(PLDc_2) 		4 GLY A  18
PHE A   4
SER A 122
ASN A   9
 None
 1.08A 5n5dB-2c1lA:
2.5		 5n5dB-2c1lA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e11 HYDROLASE

(Xanthomonas
campestris) 		PF00795
(CN_hydrolase) 		4 GLY A 259
PHE A 156
ARG A 190
ASP A 258
 None
 0.98A 5n5dB-2e11A:
undetectable		 5n5dB-2e11A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 SER A  71
ARG A 303
ASP A 207
ASN A 306
 None
 0.98A 5n5dB-2eb0A:
undetectable		 5n5dB-2eb0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 GLY A 497
PHE A 499
ASP A 488
ASN A 494
 None
 1.09A 5n5dB-2gv9A:
undetectable		 5n5dB-2gv9A:
11.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE

(Leptospira
interrogans) 		PF01596
(Methyltransf_3) 		4 GLY A  68
PHE A  70
SER A  74
ASP A 154
 SAH  A2001 (-3.3A)
SAH  A2001 (-4.4A)
SAH  A2001 (-2.9A)
SAH  A2001 (-3.3A)
 0.34A 5n5dB-2hnkA:
28.1		 5n5dB-2hnkA:
30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01842
(ACT) 		4 GLY A 199
SER A  39
ARG A 305
ASP A 202
 ASP  A 502 (-3.1A)
ASP  A 502 (-3.4A)
None
MG  A 900 (-3.9A)
 1.12A 5n5dB-2j0wA:
undetectable		 5n5dB-2j0wA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE

(Caenorhabditis
elegans) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 GLY A  21
PHE A  91
SER A 135
ARG A  70
 None
 1.04A 5n5dB-2o3jA:
6.7		 5n5dB-2o3jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1

(Streptococcus
agalactiae) 		PF13672
(PP2C_2) 		4 GLY A  37
SER A 119
ASP A  18
ASN A  15
 MG  A 501 (-4.0A)
None
MG  A 502 ( 4.7A)
None
 1.09A 5n5dB-2pk0A:
undetectable		 5n5dB-2pk0A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		4 GLY A  86
GLU A 121
ASP A 198
ASN A 205
 None
 0.72A 5n5dB-2qy6A:
12.0		 5n5dB-2qy6A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N
LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Thermosynechococcus
elongatus;
Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro)
PF00148
(Oxidored_nitro) 		4 PHE A  50
ARG B  43
ASP B  36
ASN B  40
 None
None
SF4  A 602 (-2.8A)
None
 1.02A 5n5dB-2xdqA:
undetectable		 5n5dB-2xdqA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfb E1 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF01589
(Alpha_E1_glycop) 		4 GLY A 201
PHE A 240
ARG A 206
ASP A 202
 None
 0.90A 5n5dB-2xfbA:
undetectable		 5n5dB-2xfbA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymz GALECTIN 2

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		4 GLY A 121
PHE A  31
SER A  25
ASN A 118
 None
None
SO4  A1132 ( 3.9A)
None
 1.01A 5n5dB-2ymzA:
undetectable		 5n5dB-2ymzA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bit FACT COMPLEX SUBUNIT
SPT16

(Saccharomyces
cerevisiae) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 PHE A 143
SER A  38
GLU A 146
ASN A 106
 None
 1.07A 5n5dB-3bitA:
undetectable		 5n5dB-3bitA:
17.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bwm CATECHOL
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		4 GLY A  66
SER A  72
GLU A  90
ASP A 141
 SAM  A 301 (-3.2A)
SAM  A 301 (-2.9A)
SAM  A 301 (-2.8A)
MG  A 300 (-2.4A)
 0.19A 5n5dB-3bwmA:
22.8		 5n5dB-3bwmA:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3y O-METHYLTRANSFERASE

(Mesembryanthemum
crystallinum) 		PF01596
(Methyltransf_3) 		4 GLY A  78
PHE A  80
SER A  84
ASP A 154
 SAH  A 464 (-3.7A)
SAH  A 464 (-4.9A)
SAH  A 464 (-2.8A)
CA  A 238 ( 2.2A)
 0.33A 5n5dB-3c3yA:
27.7		 5n5dB-3c3yA:
27.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cbg O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF01596
(Methyltransf_3) 		4 GLY A  68
PHE A  70
SER A  74
ASP A 143
 SAH  A 301 (-3.7A)
SAH  A 301 (-4.8A)
SAH  A 301 (-2.9A)
MG  A 401 ( 2.7A)
 0.34A 5n5dB-3cbgA:
28.6		 5n5dB-3cbgA:
33.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION

(Ruegeria
pomeroyi) 		no annotation 4 GLY A  37
SER A  41
GLU A  57
ASP A 128
 None
 0.26A 5n5dB-3cvoA:
13.5		 5n5dB-3cvoA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		4 GLY A 105
GLU A 261
ARG A 411
ASP A 107
 None
 1.10A 5n5dB-3djdA:
2.1		 5n5dB-3djdA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewm UNCHARACTERIZED
SUGAR KINASE PH1459

(Pyrococcus
horikoshii) 		PF00294
(PfkB) 		4 GLY A  20
SER A 100
GLU A  19
ASP A  21
 None
 0.89A 5n5dB-3ewmA:
3.1		 5n5dB-3ewmA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h75 PERIPLASMIC
SUGAR-BINDING DOMAIN
PROTEIN

(Pseudomonas
protegens) 		PF13407
(Peripla_BP_4) 		4 GLY A  60
PHE A  66
SER A  71
GLU A  64
 None
GOL  A 402 ( 4.0A)
None
None
 1.12A 5n5dB-3h75A:
2.8		 5n5dB-3h75A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		4 GLY A  12
GLU A  35
ARG A 138
ASP A 179
 FAD  A 536 (-3.1A)
FAD  A 536 (-2.9A)
SO4  A 544 (-3.2A)
None
 1.08A 5n5dB-3ihgA:
3.1		 5n5dB-3ihgA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqx TAIL-ANCHORED
PROTEIN TARGETING
FACTOR GET3

(Chaetomium
thermophilum) 		PF02374
(ArsA_ATPase) 		4 GLY A  33
PHE A  31
SER A  44
ARG A 252
 None
 0.76A 5n5dB-3iqxA:
undetectable		 5n5dB-3iqxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLY A 286
SER A 211
GLU A 289
ASP A 284
 None
 0.99A 5n5dB-3iv0A:
undetectable		 5n5dB-3iv0A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izq ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF08938
(HBS1_N) 		4 GLY 1 428
ARG 1 588
ASP 1 399
ASN 1 586
 None
 1.06A 5n5dB-3izq1:
undetectable		 5n5dB-3izq1:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kc2 UNCHARACTERIZED
PROTEIN YKR070W

(Saccharomyces
cerevisiae) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 GLY A  55
PHE A 161
SER A 103
ASN A 204
 None
 0.99A 5n5dB-3kc2A:
3.5		 5n5dB-3kc2A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3km5 LYSINE SPECIFIC
CYSTEINE PROTEASE

(Porphyromonas
gingivalis) 		PF07675
(Cleaved_Adhesin) 		4 GLY A1246
PHE A1244
SER A1211
ASN A1272
 None
 1.12A 5n5dB-3km5A:
undetectable		 5n5dB-3km5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l76 ASPARTOKINASE

(Synechocystis
sp. PCC 6803) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		4 GLY A 153
SER A  41
ARG A 368
ASP A 156
 None
 1.05A 5n5dB-3l76A:
undetectable		 5n5dB-3l76A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocj PUTATIVE EXPORTED
PROTEIN

(Bordetella
parapertussis) 		PF13847
(Methyltransf_31) 		4 GLY A 125
ARG A  70
ASP A 147
ASN A  64
 None
 0.99A 5n5dB-3ocjA:
13.2		 5n5dB-3ocjA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLY A  66
GLU A 101
ASP A 178
ASN A 185
 SAM  A 670 (-3.5A)
SAM  A 670 (-2.6A)
SAM  A 670 (-3.4A)
SAM  A 670 ( 4.1A)
 0.72A 5n5dB-3ps9A:
11.5		 5n5dB-3ps9A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7x MAJOR CAPSID PROTEIN
VP1

(Human
polyomavirus 4) 		PF00718
(Polyoma_coat) 		4 GLY A 254
GLU A 118
ARG A 121
ASP A 249
 None
 1.07A 5n5dB-3s7xA:
undetectable		 5n5dB-3s7xA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 GLY A 462
PHE A 460
SER A 422
ASN A 808
 None
 1.08A 5n5dB-3s9vA:
undetectable		 5n5dB-3s9vA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 302
PHE A 303
GLU A 326
ASP A  45
 None
 1.05A 5n5dB-3sjnA:
undetectable		 5n5dB-3sjnA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
ulcerans) 		PF13561
(adh_short_C2) 		4 GLY A 191
SER A 151
ARG A 194
ASP A 249
 None
 1.07A 5n5dB-3svtA:
8.4		 5n5dB-3svtA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 GLY A1558
PHE A1560
ARG A1591
ASP A1555
 None
ACR  A   1 (-3.7A)
None
None
 0.97A 5n5dB-3topA:
undetectable		 5n5dB-3topA:
13.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tr6 O-METHYLTRANSFERASE

(Coxiella
burnetii) 		PF01596
(Methyltransf_3) 		4 GLY A  69
PHE A  71
SER A  75
ASP A 144
 SAH  A 224 (-3.9A)
SAH  A 224 (-4.8A)
SAH  A 224 (-2.8A)
NI  A 223 ( 2.5A)
 0.30A 5n5dB-3tr6A:
28.8		 5n5dB-3tr6A:
30.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twd BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep) 		4 GLY A 373
SER A 359
GLU A 371
ASP A 374
 None
 1.11A 5n5dB-3twdA:
undetectable		 5n5dB-3twdA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		4 GLY A 104
GLU A 133
ASP A 193
ASN A 200
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.2A)
 0.72A 5n5dB-3vywA:
11.9		 5n5dB-3vywA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 GLU D 450
ARG D 453
ASP D 408
ASN D 388
 None
 1.11A 5n5dB-3w3aD:
undetectable		 5n5dB-3w3aD:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpw POMB

(Vibrio
alginolyticus) 		PF00691
(OmpA) 		4 GLY A 199
PHE A 196
GLU A 192
ASN A 244
 None
 1.00A 5n5dB-3wpwA:
undetectable		 5n5dB-3wpwA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz4 DOTI

(Legionella
pneumophila) 		PF11393
(T4BSS_DotI_IcmL) 		4 GLY A 198
PHE A 107
SER A 193
ARG A 159
 None
None
None
MPD  A 504 (-2.7A)
 0.87A 5n5dB-3wz4A:
undetectable		 5n5dB-3wz4A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 GLY A 371
PHE A 281
ARG A 353
ASN A 356
 None
 1.02A 5n5dB-4azvA:
14.2		 5n5dB-4azvA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 GLY A 371
PHE A 281
ARG A 353
ASN A 356
 None
None
None
MG  A1452 ( 2.7A)
 1.10A 5n5dB-4azwA:
13.6		 5n5dB-4azwA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF14574
(DUF4445) 		4 GLY I 460
GLU I 426
ASP I 469
ASN I 473
 None
 0.99A 5n5dB-4c1nI:
undetectable		 5n5dB-4c1nI:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 GLY A 534
GLU A 474
ASP A 536
ASN A 347
 None
 1.11A 5n5dB-4c22A:
2.8		 5n5dB-4c22A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2t DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 GLY A  96
PHE A  92
SER A  90
ARG A 205
 None
 0.94A 5n5dB-4c2tA:
undetectable		 5n5dB-4c2tA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 GLY A  96
PHE A  92
SER A  90
ARG A 205
 None
 0.93A 5n5dB-4c30A:
3.4		 5n5dB-4c30A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 GLY A 394
GLU A 648
ASP A 373
ASN A 675
 None
 1.02A 5n5dB-4cakA:
undetectable		 5n5dB-4cakA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpg LYSINE--TRNA LIGASE

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 GLY A 326
GLU A 325
ASP A 328
ASN A 332
 None
APC  A 602 ( 4.7A)
None
None
 1.02A 5n5dB-4dpgA:
undetectable		 5n5dB-4dpgA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk1 PUTATIVE THIOREDOXIN
REDUCTASE

(Bacillus
anthracis) 		PF07992
(Pyr_redox_2) 		4 GLY C 111
PHE C 231
GLU C 269
ASN C  37
 FAD  C 500 (-3.5A)
None
FAD  C 500 (-3.2A)
FAD  C 500 (-4.6A)
 1.10A 5n5dB-4fk1C:
3.6		 5n5dB-4fk1C:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbu VIRULENCE-ASSOCIATED
V ANTIGEN

(Yersinia pestis) 		PF04792
(LcrV) 		4 PHE A 104
SER A 108
ARG A 150
ASP A 141
 None
 1.05A 5n5dB-4jbuA:
undetectable		 5n5dB-4jbuA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLY A 435
PHE A 431
SER A 177
ARG A 275
 None
None
2JG  A 176 ( 4.0A)
None
 0.80A 5n5dB-4na3A:
undetectable		 5n5dB-4na3A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nek ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE

(Magnetospirillum
magneticum) 		PF00378
(ECH_1) 		4 GLY A  42
PHE A  39
GLU A  43
ASN A  49
 None
 1.10A 5n5dB-4nekA:
undetectable		 5n5dB-4nekA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opf NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A6514
PHE A6510
SER A6275
ARG A6373
 None
 1.02A 5n5dB-4opfA:
undetectable		 5n5dB-4opfA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4o DNA POLYMERASE BETA

(Leishmania
infantum) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 GLY A 193
PHE A 191
SER A 158
ASN A 150
 D3T  A 401 (-3.7A)
None
None
None
 0.80A 5n5dB-4p4oA:
undetectable		 5n5dB-4p4oA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		4 GLY A 109
SER A 115
GLU A 133
ASP A 184
 2F6  A 301 (-3.6A)
None
2F6  A 301 (-2.7A)
None
 0.70A 5n5dB-4p58A:
21.9		 5n5dB-4p58A:
28.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN

(Anaplasma
phagocytophilum) 		PF01596
(Methyltransf_3) 		5 GLY A  64
SER A  70
GLU A  88
ASP A 136
ASN A 138
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-2.6A)
MN  A 303 ( 2.7A)
SAM  A 301 (-3.4A)
 0.21A 5n5dB-4pclA:
29.3		 5n5dB-4pclA:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlo HOMOSERINE
O-ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF00561
(Abhydrolase_1) 		4 GLY A 263
PHE A 288
ASP A 272
ASN A 293
 None
 1.04A 5n5dB-4qloA:
2.7		 5n5dB-4qloA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLY A2965
PHE A2961
SER A2712
ARG A2810
 None
 0.86A 5n5dB-4qyrA:
undetectable		 5n5dB-4qyrA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		no annotation
no annotation 		4 GLY B  59
PHE B 196
ARG A  63
ASN B  57
 None
 0.92A 5n5dB-4r1dB:
undetectable		 5n5dB-4r1dB:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ymg PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE

(Podospora
anserina) 		PF01596
(Methyltransf_3) 		5 GLY A  73
SER A  79
GLU A  98
ASP A 144
ASN A 146
 SAM  A1001 (-3.3A)
SAM  A1001 (-2.7A)
SAM  A1001 (-2.7A)
SAM  A1001 (-3.6A)
SAM  A1001 ( 3.5A)
 0.21A 5n5dB-4ymgA:
25.5		 5n5dB-4ymgA:
30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yo0 LIGHT CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B  84
PHE B  82
ARG B  70
ASN B  54
 None
 0.94A 5n5dB-4yo0B:
undetectable		 5n5dB-4yo0B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE

(Sinorhizobium
meliloti) 		PF06253
(MTTB) 		4 GLY A 178
PHE A 207
SER A 175
ARG A 191
 None
 1.03A 5n5dB-4yycA:
undetectable		 5n5dB-4yycA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 PHE A  38
SER A  33
GLU A  83
ASP A  40
 None
 1.04A 5n5dB-4zajA:
undetectable		 5n5dB-4zajA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgz ANTIZYME INHIBITOR 1
ORNITHINE
DECARBOXYLASE
ANTIZYME 1

(Homo sapiens;
Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
PF02100
(ODC_AZ) 		4 SER B 191
GLU A  94
ASP A 387
ASN A  71
 None
 1.10A 5n5dB-4zgzB:
2.0		 5n5dB-4zgzB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4znj PHAGE TERMINASE
LARGE SUBUNIT

(Thermus virus
P74-26) 		PF03237
(Terminase_6) 		4 GLY A 201
PHE A 252
SER A 205
ARG A 236
 None
 0.96A 5n5dB-4znjA:
4.8		 5n5dB-4znjA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrx F5/8 TYPE C DOMAIN
PROTEIN

(Bacteroides
ovatus) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		4 GLY A 443
SER A 472
ARG A 254
ASN A 259
 None
 1.09A 5n5dB-4zrxA:
undetectable		 5n5dB-4zrxA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqe MATRIX PROTEIN 1

(Influenza A
virus) 		PF00598
(Flu_M1) 		4 GLY A  58
PHE A  62
ARG A  78
ASN A  85
 None
 1.07A 5n5dB-5cqeA:
undetectable		 5n5dB-5cqeA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eef HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 GLY A 191
PHE A 205
SER A 164
ASN A 200
 None
 0.83A 5n5dB-5eefA:
4.4		 5n5dB-5eefA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 GLY A1926
SER A1906
ARG A2227
ASP A1866
 None
 1.07A 5n5dB-5i6gA:
undetectable		 5n5dB-5i6gA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 GLY A1926
SER A1906
ARG A2227
ASP A1866
 None
 1.09A 5n5dB-5i6hA:
undetectable		 5n5dB-5i6hA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 GLY A1926
SER A1906
ARG A2227
ASP A1866
 None
 0.99A 5n5dB-5i6iA:
undetectable		 5n5dB-5i6iA:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN

(Trichodesmium
erythraeum) 		no annotation 4 GLY A 158
PHE A 156
SER A 133
ASP A 127
 None
None
2PO  A 301 ( 4.4A)
None
 1.00A 5n5dB-5jvbA:
2.4		 5n5dB-5jvbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens;
Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3)
PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 GLY A 655
SER A 710
GLU B1793
ASN B1805
 None
 1.02A 5n5dB-5k8dA:
undetectable		 5n5dB-5k8dA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR

(Yersinia
enterocolitica) 		PF03472
(Autoind_bind) 		4 GLY A  27
PHE A 136
ARG A  22
ASP A  28
 None
None
EDO  A 203 (-3.9A)
None
 1.11A 5n5dB-5l09A:
undetectable		 5n5dB-5l09A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa) 		PF00305
(Lipoxygenase) 		4 GLY A 429
ARG A 422
ASP A 432
ASN A  85
 None
None
GOL  A 702 (-2.9A)
None
 1.10A 5n5dB-5lc8A:
undetectable		 5n5dB-5lc8A:
15.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5log PUTATIVE
O-METHYLTRANSFERASE

(Myxococcus
xanthus) 		PF01596
(Methyltransf_3) 		4 GLY A  67
PHE A  69
SER A  73
ASP A 142
 SAH  A1001 (-3.5A)
None
SAH  A1001 (-2.7A)
MG  A1002 (-2.5A)
 0.29A 5n5dB-5logA:
29.3		 5n5dB-5logA:
34.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv1 PTXB

(Prochlorococcus
marinus) 		no annotation 4 GLY A 158
PHE A 156
SER A 133
ASP A 127
 None
None
78T  A 301 ( 4.6A)
None
 1.00A 5n5dB-5lv1A:
2.3		 5n5dB-5lv1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m86 TA1207

(Thermoplasma
acidophilum) 		no annotation 4 GLY A 235
PHE A 254
GLU A 236
ASN A 210
 None
 0.89A 5n5dB-5m86A:
undetectable		 5n5dB-5m86A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C)
PF04616
(Glyco_hydro_43) 		4 GLY A 258
SER A 248
GLU A 279
ARG A 283
 None
 1.10A 5n5dB-5msxA:
undetectable		 5n5dB-5msxA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5d METHYLTRANSFERASE

(Streptomyces
regensis) 		PF01596
(Methyltransf_3) 		7 GLY A  65
PHE A  67
SER A  71
GLU A  89
ARG A 117
ASP A 139
ASN A 141
 SAM  A 306 (-3.2A)
SAM  A 306 (-4.2A)
SAM  A 306 (-2.2A)
SAM  A 306 (-2.4A)
None
SAM  A 306 (-2.3A)
SAM  A 306 ( 2.9A)
 0.38A 5n5dB-5n5dA:
40.6		 5n5dB-5n5dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5d METHYLTRANSFERASE

(Streptomyces
regensis) 		PF01596
(Methyltransf_3) 		6 GLY A  65
PHE A  67
SER A  72
GLU A  89
ARG A 117
ASN A 141
 SAM  A 306 (-3.2A)
SAM  A 306 (-4.2A)
None
SAM  A 306 (-2.4A)
None
SAM  A 306 ( 2.9A)
 1.12A 5n5dB-5n5dA:
40.6		 5n5dB-5n5dA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2j PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN PTXB

(Pseudomonas
stutzeri) 		no annotation 4 GLY A 153
PHE A 151
SER A 127
ASP A 121
 None
None
2PO  A 301 ( 4.7A)
None
 1.11A 5n5dB-5o2jA:
2.6		 5n5dB-5o2jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vu2 E1 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		no annotation 4 GLY M 201
PHE M 240
ARG M 206
ASP M 202
 None
 0.90A 5n5dB-5vu2M:
undetectable		 5n5dB-5vu2M:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C

(Mycobacterium
tuberculosis) 		PF01596
(Methyltransf_3) 		4 GLY A  66
SER A  72
ARG A 119
ASP A 138
 SAM  A 301 (-3.5A)
SAM  A 301 (-2.8A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.6A)
 0.79A 5n5dB-5x7fA:
26.8		 5n5dB-5x7fA:
34.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcv VL-SARAH(S37C)
CHIMERA,VL-SARAH(S37
C) CHIMERA

(Homo sapiens;
Rattus) 		no annotation 4 GLY B  64
PHE B  62
ARG B  50
ASN B  34
 None
 0.92A 5n5dB-5xcvB:
undetectable		 5n5dB-5xcvB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 4 SER A 265
GLU A 297
ARG A 224
ASP A 236
 None
A  B  12 ( 2.6A)
A  B  19 ( 3.2A)
U  B  16 ( 3.8A)
 0.92A 5n5dB-5xwyA:
undetectable		 5n5dB-5xwyA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM

(Bacillus
subtilis) 		no annotation 4 GLY A  62
SER A  68
GLU A  85
ASP A 133
 SAM  A 302 (-3.4A)
SAM  A 302 (-2.7A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.6A)
 0.19A 5n5dB-5zw4A:
24.5		 5n5dB-5zw4A:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cr0 (S)-6-HYDROXYNICOTIN
E OXIDASE

(Shinella sp.
HZN7) 		no annotation 4 GLY A 172
SER A 378
ARG A 147
ASP A 289
 None
 1.10A 5n5dB-6cr0A:
undetectable		 5n5dB-6cr0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE

(Schizosaccharomyces
pombe) 		no annotation 4 GLY A  17
SER A 311
GLU A  11
ASN A  24
 SAH  A 401 ( 4.7A)
SAH  A 401 (-2.8A)
None
None
 1.07A 5n5dB-6fdfA:
8.7		 5n5dB-6fdfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C1,
MITOCHONDRIAL

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 GLY O  64
PHE c   2
ASP O  65
ASN O 309
 None
 1.11A 5n5dB-6g2jO:
undetectable		 5n5dB-6g2jO:
undetectable