SIMILAR PATTERNS OF AMINO ACIDS FOR 5N5D_A_SAMA306_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis)
PF00405
(Transferrin)
4 LEU A 299
PHE A 300
GLU A  80
ASP A 302
None
1.04A 5n5dA-1biyA:
undetectable
5n5dA-1biyA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em2 MLN64 PROTEIN

(Homo sapiens)
PF01852
(START)
4 LEU A 434
PHE A 430
ILE A 284
ASP A 269
None
1.06A 5n5dA-1em2A:
undetectable
5n5dA-1em2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE


(Nicotiana
tabacum)
PF01053
(Cys_Met_Meta_PP)
4 LEU A 133
SER A 124
ILE A 304
ASN A 113
None
1.05A 5n5dA-1i41A:
4.4
5n5dA-1i41A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis)
PF00026
(Asp)
4 LEU A 297
SER A 293
ILE A 289
ASP A 223
None
1.06A 5n5dA-1ibqA:
undetectable
5n5dA-1ibqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jct GLUCARATE
DEHYDRATASE


(Escherichia
coli)
PF13378
(MR_MLE_C)
4 LEU A  28
ILE A 220
GLU A 216
ASP A 235
None
None
None
MG  A 498 ( 2.6A)
0.87A 5n5dA-1jctA:
undetectable
5n5dA-1jctA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1


(Paracoccus
denitrificans)
PF01011
(PQQ)
PF13360
(PQQ_2)
4 LEU A 367
ILE A 346
ASP A 364
ASN A 217
None
0.95A 5n5dA-1lrwA:
undetectable
5n5dA-1lrwA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsa PROCARBOXYPEPTIDASE
B


(Sus scrofa)
PF00246
(Peptidase_M14)
PF02244
(Propep_M14)
4 SER A 207
ILE A 202
GLU A 270
ASP A 255
BEN  A   1 (-3.5A)
None
ZN  A 501 ( 4.9A)
BEN  A   1 (-3.1A)
1.01A 5n5dA-1nsaA:
undetectable
5n5dA-1nsaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr7 PHENYLALANINE-REGULA
TED
3-DEOXY-D-ARABINO-HE
PTULOSONATE-7-PHOSPH
ATE SYNTHASE


(Escherichia
coli)
PF00793
(DAHP_synth_1)
4 LEU A 107
PHE A  95
ILE A 148
ASN A 120
None
1.01A 5n5dA-1qr7A:
undetectable
5n5dA-1qr7A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE


(Staphylococcus
aureus)
PF00348
(polyprenyl_synt)
4 LEU A  63
SER A  67
ILE A 135
ASP A 126
None
0.89A 5n5dA-1rtrA:
undetectable
5n5dA-1rtrA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tx4 P50-RHOGAP

(Homo sapiens)
PF00620
(RhoGAP)
4 LEU A 226
PHE A 222
ILE A 216
ASN A 202
None
1.02A 5n5dA-1tx4A:
undetectable
5n5dA-1tx4A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlu GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE


(Saccharomyces
cerevisiae)
PF00171
(Aldedh)
4 SER A   2
ILE A 199
GLU A 197
ASP A 191
None
1.06A 5n5dA-1vluA:
undetectable
5n5dA-1vluA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT


(Acetoanaerobium
sticklandii)
PF09043
(Lys-AminoMut_A)
4 LEU A   7
PHE A   9
GLU A  13
ASN A 462
None
0.81A 5n5dA-1xrsA:
undetectable
5n5dA-1xrsA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP


(Escherichia
coli)
PF01432
(Peptidase_M3)
4 LEU 1  90
PHE 1  94
SER 1 169
GLU 1  97
None
1.06A 5n5dA-1y791:
undetectable
5n5dA-1y791:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztc HYPOTHETICAL PROTEIN
TM0894


(Thermotoga
maritima)
PF00753
(Lactamase_B)
4 LEU A  80
SER A 114
ILE A 107
ASN A  41
None
0.82A 5n5dA-1ztcA:
undetectable
5n5dA-1ztcA:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2avd CATECHOL-O-METHYLTRA
NSFERASE


(Homo sapiens)
PF01596
(Methyltransf_3)
4 PHE A 112
SER A 116
GLU A 134
ASP A 185
SAM  A 501 (-4.7A)
SAM  A 501 (-3.0A)
SAM  A 501 (-2.9A)
SAM  A 501 (-3.4A)
0.28A 5n5dA-2avdA:
28.4
5n5dA-2avdA:
34.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE


(Prosthecochloris
vibrioformis)
PF00490
(ALAD)
4 SER A 158
ILE A 103
GLU A  96
ASP A 100
None
1.05A 5n5dA-2c1hA:
2.2
5n5dA-2c1hA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM


(Oryctolagus
cuniculus)
PF00343
(Phosphorylase)
4 LEU A 652
ILE A 125
GLU A 124
ASP A 128
None
0.96A 5n5dA-2gj4A:
3.1
5n5dA-2gj4A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmy HYPOTHETICAL PROTEIN
ATU0492


(Agrobacterium
fabrum)
PF02627
(CMD)
4 ILE A  98
GLU A 100
ASP A  93
ASN A  46
None
0.92A 5n5dA-2gmyA:
undetectable
5n5dA-2gmyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ngr PROTEIN (GTPASE
ACTIVATING PROTEIN
(RHG))


(Homo sapiens)
PF00620
(RhoGAP)
4 LEU B 446
PHE B 442
ILE B 436
ASN B 422
None
1.01A 5n5dA-2ngrB:
undetectable
5n5dA-2ngrB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvp D-ALANINE-D-ALANINE
LIGASE


(Helicobacter
pylori)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
4 LEU A 279
PHE A 280
ILE A 117
ASP A 281
None
0.96A 5n5dA-2pvpA:
undetectable
5n5dA-2pvpA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhp FRUCTOKINASE

(Bacteroides
thetaiotaomicron)
PF00294
(PfkB)
4 LEU A 164
PHE A 168
ILE A 149
ASN A 153
None
EDO  A 298 ( 4.9A)
None
None
1.02A 5n5dA-2qhpA:
3.9
5n5dA-2qhpA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE


(Streptococcus
pneumoniae)
PF01128
(IspD)
4 ILE A 107
GLU A 105
ASP A 134
ASN A 132
None
0.94A 5n5dA-2vsiA:
3.4
5n5dA-2vsiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbv FIBER PROTEIN

(Canine
mastadenovirus
A)
no annotation 4 LEU A 512
PHE A 514
SER A 419
ILE A 477
None
None
SIA  A1545 (-4.4A)
None
1.06A 5n5dA-2wbvA:
undetectable
5n5dA-2wbvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF00171
(Aldedh)
4 LEU A 415
SER A 411
ILE A 388
GLU A 387
NAD  A 500 ( 4.6A)
None
None
NAD  A 500 (-2.8A)
0.99A 5n5dA-3b4wA:
5.3
5n5dA-3b4wA:
18.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bwm CATECHOL
O-METHYLTRANSFERASE


(Homo sapiens)
PF01596
(Methyltransf_3)
4 SER A  72
ILE A  89
GLU A  90
ASP A 141
SAM  A 301 (-2.9A)
SAM  A 301 ( 4.9A)
SAM  A 301 (-2.8A)
MG  A 300 (-2.4A)
0.29A 5n5dA-3bwmA:
22.8
5n5dA-3bwmA:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3y O-METHYLTRANSFERASE

(Mesembryanthemum
crystallinum)
PF01596
(Methyltransf_3)
4 PHE A  80
SER A  84
ILE A 101
ASP A 154
SAH  A 464 (-4.9A)
SAH  A 464 (-2.8A)
None
CA  A 238 ( 2.2A)
0.40A 5n5dA-3c3yA:
27.3
5n5dA-3c3yA:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM


(Homo sapiens)
PF00343
(Phosphorylase)
4 LEU A 652
ILE A 125
GLU A 124
ASP A 128
None
0.91A 5n5dA-3cemA:
3.2
5n5dA-3cemA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'


(Homo sapiens)
PF00069
(Pkinase)
4 ILE X  85
GLU X 181
ASP X  26
ASN X  17
None
1.05A 5n5dA-3e3bX:
undetectable
5n5dA-3e3bX:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqz RESPONSE REGULATOR

(Colwellia
psychrerythraea)
PF00072
(Response_reg)
4 LEU A  41
SER A  72
ILE A  77
ASP A  47
LEU  A  41 ( 0.6A)
SER  A  72 ( 0.0A)
ILE  A  77 ( 0.7A)
ASP  A  47 ( 0.6A)
0.94A 5n5dA-3eqzA:
3.2
5n5dA-3eqzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7w PUTATIVE
FRUCTOSAMINE-3-KINAS
E


(Thermobifida
fusca)
PF03881
(Fructosamin_kin)
4 LEU A  86
SER A  25
ILE A 127
ASP A 210
None
0.99A 5n5dA-3f7wA:
undetectable
5n5dA-3f7wA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg9 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
OXIDOREDUCTASE
PROTEIN


(Ralstonia
solanacearum)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
4 LEU A 234
ILE A  98
GLU A  66
ASP A  93
None
1.03A 5n5dA-3gg9A:
5.1
5n5dA-3gg9A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtu GLUTATHIONE
S-TRANSFERASE


(Homo sapiens)
PF00043
(GST_C)
PF02798
(GST_N)
4 LEU B  23
PHE B 161
ILE B 166
ASN B  77
None
0.91A 5n5dA-3gtuB:
undetectable
5n5dA-3gtuB:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus)
PF00759
(Glyco_hydro_9)
PF02927
(CelD_N)
4 PHE A 409
ILE A 480
ASP A 475
ASN A   6
None
1.00A 5n5dA-3h7lA:
undetectable
5n5dA-3h7lA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN


(Shewanella
oneidensis)
PF16113
(ECH_2)
4 LEU A 315
PHE A 319
GLU A 322
ASN A 173
None
0.95A 5n5dA-3ju1A:
undetectable
5n5dA-3ju1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ku0 RIBOSOME-INACTIVATIN
G PROTEIN GELONIN


(Suregada
multiflora)
PF00161
(RIP)
4 LEU A  63
ILE A 135
ASP A 141
ASN A  60
None
1.06A 5n5dA-3ku0A:
undetectable
5n5dA-3ku0A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxi GTP-BINDING PROTEIN
(HFLX)


(Sulfolobus
solfataricus)
PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M)
4 LEU A 274
SER A 320
ILE A 331
ASN A 300
None
None
None
GDP  A 500 (-3.0A)
0.98A 5n5dA-3kxiA:
2.6
5n5dA-3kxiA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm7 PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE /
2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE


(Yersinia
enterocolitica)
PF07071
(KDGP_aldolase)
4 ILE A 221
GLU A 232
ASP A 223
ASN A  23
None
1.07A 5n5dA-3lm7A:
2.3
5n5dA-3lm7A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lms CARBOXYPEPTIDASE B2

(Homo sapiens)
PF00246
(Peptidase_M14)
4 SER A 207
ILE A 202
GLU A 270
ASP A 255
None
None
GLY  A 501 ( 4.6A)
None
0.91A 5n5dA-3lmsA:
undetectable
5n5dA-3lmsA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A


(Thermotoga
maritima)
PF00005
(ABC_tran)
4 LEU A 152
SER A 221
ILE A 209
ASN A 237
None
1.02A 5n5dA-3pihA:
undetectable
5n5dA-3pihA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2j DIPEPTIDASE

(Streptomyces
coelicolor)
PF01244
(Peptidase_M19)
4 LEU A 186
SER A 190
ILE A 317
ASN A 361
None
0.97A 5n5dA-3s2jA:
undetectable
5n5dA-3s2jA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3two MANNITOL
DEHYDROGENASE


(Helicobacter
pylori)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 PHE A 337
ILE A  41
ASP A 316
ASN A 329
None
0.94A 5n5dA-3twoA:
7.7
5n5dA-3twoA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE


(Gluconobacter
oxydans)
PF00171
(Aldedh)
4 LEU A 389
SER A 385
ILE A 362
GLU A 361
None
0.93A 5n5dA-3vz0A:
6.0
5n5dA-3vz0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0l CULLIN-4B

(Homo sapiens)
PF00888
(Cullin)
PF10557
(Cullin_Nedd8)
4 SER E 282
ILE E 354
GLU E 355
ASP E 348
None
0.73A 5n5dA-4a0lE:
undetectable
5n5dA-4a0lE:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5r A49

(Vaccinia virus)
PF06489
(Orthopox_A49R)
4 LEU A  65
PHE A  61
ILE A  42
ASN A  49
None
0.93A 5n5dA-4d5rA:
undetectable
5n5dA-4d5rA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1t INVASIN

(Yersinia
pseudotuberculosis)
PF11924
(IAT_beta)
4 LEU A 301
PHE A 302
GLU A 341
ASN A 384
None
1.05A 5n5dA-4e1tA:
undetectable
5n5dA-4e1tA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
4 LEU A 103
PHE A 202
ILE A 207
ASN A  87
None
MLY  A 138 ( 3.9A)
MLY  A 206 ( 4.0A)
None
1.01A 5n5dA-4f6eA:
undetectable
5n5dA-4f6eA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE


(Pseudomonas
mendocina)
PF13378
(MR_MLE_C)
4 LEU A  30
ILE A 237
GLU A 233
ASP A 252
None
0.98A 5n5dA-4hn8A:
undetectable
5n5dA-4hn8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyl ENOYL-COA HYDRATASE

(Thermoplasma
volcanium)
PF00378
(ECH_1)
4 ILE A   5
GLU A   4
ASP A  32
ASN A  -5
None
0.86A 5n5dA-4jylA:
undetectable
5n5dA-4jylA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrh COPN
CHAPERONE SYCD


(Chlamydia
pneumoniae;
Chlamydia
pneumoniae)
PF07201
(HrpJ)
PF07720
(TPR_3)
4 SER B  51
ILE A 136
GLU A 111
ASN A 104
None
1.04A 5n5dA-4nrhB:
undetectable
5n5dA-4nrhB:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o89 RNA 3'-TERMINAL
PHOSPHATE CYCLASE


(Pyrococcus
horikoshii)
PF01137
(RTC)
PF05189
(RTC_insert)
4 LEU A 140
PHE A 291
SER A 295
ILE A 335
None
0.92A 5n5dA-4o89A:
4.0
5n5dA-4o89A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE


(Streptococcus
pyogenes)
PF00171
(Aldedh)
4 LEU A 388
SER A 384
ILE A 361
GLU A 360
None
1.07A 5n5dA-4ohtA:
5.5
5n5dA-4ohtA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pav GLYOXALASE FAMILY
PROTEIN


(Staphylococcus
aureus)
PF00903
(Glyoxalase)
4 SER A  17
ILE A  51
GLU A  52
ASP A 116
None
0.92A 5n5dA-4pavA:
undetectable
5n5dA-4pavA:
18.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN


(Anaplasma
phagocytophilum)
PF01596
(Methyltransf_3)
4 LEU A  35
ILE A  87
GLU A  88
ASN A 138
None
None
SAM  A 301 (-2.6A)
SAM  A 301 (-3.4A)
1.01A 5n5dA-4pclA:
29.6
5n5dA-4pclA:
31.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN


(Anaplasma
phagocytophilum)
PF01596
(Methyltransf_3)
5 SER A  70
ILE A  87
GLU A  88
ASP A 136
ASN A 138
SAM  A 301 (-2.9A)
None
SAM  A 301 (-2.6A)
MN  A 303 ( 2.7A)
SAM  A 301 (-3.4A)
0.22A 5n5dA-4pclA:
29.6
5n5dA-4pclA:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A


(Saccharomyces
cerevisiae)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
4 LEU A 439
PHE A 377
ILE A 374
ASP A 290
None
None
None
CA  A1204 (-2.8A)
0.95A 5n5dA-4ptfA:
undetectable
5n5dA-4ptfA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puc SUSD HOMOLOG

(Bacteroides
uniformis)
PF12741
(SusD-like)
4 PHE A  67
SER A 107
ILE A  58
ASP A  61
None
0.86A 5n5dA-4pucA:
undetectable
5n5dA-4pucA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B


(Danio rerio)
PF06662
(C5-epim_C)
4 LEU A 484
SER A 420
ILE A 181
ASN A 478
None
None
SGN  A 802 (-4.4A)
UAP  A 801 ( 4.6A)
1.04A 5n5dA-4pxqA:
undetectable
5n5dA-4pxqA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR


(Homo sapiens)
PF00021
(UPAR_LY6)
4 LEU U 184
PHE U 165
ILE U 130
ASN U 162
None
0.89A 5n5dA-4qtiU:
undetectable
5n5dA-4qtiU:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2h STIV B204 ATPASE

(Sulfolobus
turreted
icosahedral
virus 1)
no annotation 4 PHE A  53
ILE A  37
ASP A  40
ASN A  56
None
1.06A 5n5dA-4r2hA:
3.0
5n5dA-4r2hA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1


(Streptomyces
avermitilis)
PF00698
(Acyl_transf_1)
4 LEU A 263
SER A 130
ILE A 124
GLU A 123
None
0.97A 5n5dA-4rl1A:
undetectable
5n5dA-4rl1A:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wat PFRH5

(Plasmodium
falciparum)
no annotation 4 LEU A 479
SER A 485
ILE A 235
GLU A 416
None
IMD  A1102 (-3.0A)
None
None
1.05A 5n5dA-4watA:
undetectable
5n5dA-4watA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE


(Streptomyces
lividans)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N)
4 LEU A 437
SER A 419
ILE A 441
GLU A 443
EDO  A 705 (-4.1A)
EDO  A 706 (-3.4A)
None
None
1.06A 5n5dA-4wd1A:
4.4
5n5dA-4wd1A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP


(Pseudomonas
putida)
PF03480
(DctP)
4 LEU A 175
PHE A 176
ILE A 188
ASN A 181
None
1.06A 5n5dA-4xfeA:
undetectable
5n5dA-4xfeA:
20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ymg PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE


(Podospora
anserina)
PF01596
(Methyltransf_3)
4 SER A  79
GLU A  98
ASP A 144
ASN A 146
SAM  A1001 (-2.7A)
SAM  A1001 (-2.7A)
SAM  A1001 (-3.6A)
SAM  A1001 ( 3.5A)
0.15A 5n5dA-4ymgA:
25.4
5n5dA-4ymgA:
30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzf BAND 3 ANION
TRANSPORT PROTEIN


(Homo sapiens)
PF00955
(HCO3_cotransp)
4 LEU A 530
PHE A 526
SER A 799
ILE A 684
None
0.93A 5n5dA-4yzfA:
undetectable
5n5dA-4yzfA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
4 LEU A 336
ILE A 316
ASP A 338
ASN A 311
None
None
None
NAG  A 705 (-1.8A)
1.05A 5n5dA-4z64A:
undetectable
5n5dA-4z64A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE


(Homo sapiens)
PF02350
(Epimerase_2)
4 SER A 229
ILE A 142
GLU A  81
ASP A 225
None
0.92A 5n5dA-4zhtA:
2.8
5n5dA-4zhtA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE


(Helicobacter
pylori)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
4 LEU A 260
SER A 286
ILE A 187
ASN A 235
ZN  A 501 ( 4.8A)
None
None
None
0.97A 5n5dA-4zi6A:
2.2
5n5dA-4zi6A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus)
PF04196
(Bunya_RdRp)
PF15518
(L_protein_N)
4 LEU A1001
ILE A1193
GLU A1056
ASN A1189
None
0.99A 5n5dA-5amqA:
undetectable
5n5dA-5amqA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axh DEXTRANASE

(Thermoanaerobacter
pseudethanolicus)
PF13199
(Glyco_hydro_66)
4 LEU A 458
PHE A 420
SER A 461
ASN A 541
None
None
PO4  A 705 ( 2.6A)
None
1.05A 5n5dA-5axhA:
undetectable
5n5dA-5axhA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME


(Homo sapiens)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48)
4 SER A 255
ILE A 176
ASP A 298
ASN A 170
None
0.93A 5n5dA-5clwA:
undetectable
5n5dA-5clwA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG


(Homo sapiens)
PF02724
(CDC45)
5 LEU A 311
PHE A 300
SER A 304
ILE A 430
ASN A 292
None
1.48A 5n5dA-5dgoA:
undetectable
5n5dA-5dgoA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5


(Homo sapiens)
PF00005
(ABC_tran)
PF01061
(ABC2_membrane)
4 LEU A 422
PHE A 426
SER A 572
ILE A 539
None
1.05A 5n5dA-5do7A:
undetectable
5n5dA-5do7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejy MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum)
PF00784
(MyTH4)
4 SER A 305
ILE A 253
ASP A 302
ASN A 216
None
1.01A 5n5dA-5ejyA:
undetectable
5n5dA-5ejyA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT


(Escherichia
coli;
Escherichia
coli)
PF00111
(Fer2)
PF01799
(Fer2_2)
PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
4 LEU B  96
SER B 236
ILE A 199
GLU A 198
None
0.72A 5n5dA-5g5gB:
undetectable
5n5dA-5g5gB:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17


(Sphingomonas
sp. PAMC 26605)
PF00067
(p450)
4 LEU A 157
SER A 219
GLU A 114
ASN A 121
None
1.05A 5n5dA-5h1zA:
undetectable
5n5dA-5h1zA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris)
PF12783
(Sec7_N)
PF16213
(DCB)
4 LEU A 346
PHE A 316
SER A 320
ILE A 380
None
0.96A 5n5dA-5hasA:
undetectable
5n5dA-5hasA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM


(Homo sapiens)
PF00343
(Phosphorylase)
4 LEU A 652
ILE A 125
GLU A 124
ASP A 128
None
0.95A 5n5dA-5ikpA:
undetectable
5n5dA-5ikpA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))


(Thermoplasma
acidophilum)
PF00171
(Aldedh)
4 LEU A 409
SER A 405
ILE A 382
GLU A 381
None
0.87A 5n5dA-5izdA:
5.6
5n5dA-5izdA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans)
PF03055
(RPE65)
4 PHE A 309
SER A   9
ASP A  56
ASN A 103
None
0.99A 5n5dA-5j55A:
undetectable
5n5dA-5j55A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE


(Rhizobium
leguminosarum)
PF00920
(ILVD_EDD)
4 LEU A  40
PHE A  80
SER A  13
ILE A 244
None
1.00A 5n5dA-5j84A:
2.4
5n5dA-5j84A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8b ALPHA-L-ARABINOFURAN
OSIDASE II


(Lactobacillus
brevis)
PF04616
(Glyco_hydro_43)
4 LEU A 140
PHE A 138
ILE A 162
ASN A 201
TRS  A 402 (-4.3A)
None
None
None
1.04A 5n5dA-5m8bA:
undetectable
5n5dA-5m8bA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8e ALPHA-N-ARABINOFURAN
OSIDASE


(Weissella
cibaria)
PF04616
(Glyco_hydro_43)
4 LEU A 138
PHE A 136
ILE A 160
ASN A 199
GOL  A 404 (-4.3A)
GOL  A 404 (-4.0A)
None
None
1.03A 5n5dA-5m8eA:
undetectable
5n5dA-5m8eA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
ALPHA-1


(Mus musculus)
PF00054
(Laminin_G_1)
PF06009
(Laminin_II)
4 PHE A2217
SER A2517
ILE A2214
ASN A2286
None
1.03A 5n5dA-5mc9A:
undetectable
5n5dA-5mc9A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqc VP1
VP2
VP3


(Black queen
cell virus;
Black queen
cell virus;
Black queen
cell virus)
PF08762
(CRPV_capsid)
PF00073
(Rhv)
no annotation
4 LEU C 257
ILE A  74
GLU A 111
ASN B 139
None
0.90A 5n5dA-5mqcC:
undetectable
5n5dA-5mqcC:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5d METHYLTRANSFERASE

(Streptomyces
regensis)
PF01596
(Methyltransf_3)
4 LEU A  39
PHE A  67
SER A  71
ILE A  64
SAM  A 306 (-3.5A)
SAM  A 306 (-4.2A)
SAM  A 306 (-2.2A)
None
0.82A 5n5dA-5n5dA:
43.4
5n5dA-5n5dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5d METHYLTRANSFERASE

(Streptomyces
regensis)
PF01596
(Methyltransf_3)
7 LEU A  39
PHE A  67
SER A  71
ILE A  88
GLU A  89
ASP A 139
ASN A 141
SAM  A 306 (-3.5A)
SAM  A 306 (-4.2A)
SAM  A 306 (-2.2A)
SAM  A 306 ( 4.2A)
SAM  A 306 (-2.4A)
SAM  A 306 (-2.3A)
SAM  A 306 ( 2.9A)
0.00A 5n5dA-5n5dA:
43.4
5n5dA-5n5dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5d METHYLTRANSFERASE

(Streptomyces
regensis)
PF01596
(Methyltransf_3)
5 PHE A  67
SER A  72
ILE A  88
GLU A  89
ASN A 141
SAM  A 306 (-4.2A)
None
SAM  A 306 ( 4.2A)
SAM  A 306 (-2.4A)
SAM  A 306 ( 2.9A)
1.16A 5n5dA-5n5dA:
43.4
5n5dA-5n5dA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL


(Homo sapiens)
PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C)
4 ILE A 507
GLU A 506
ASP A 548
ASN A 504
None
1.00A 5n5dA-5o1pA:
7.0
5n5dA-5o1pA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG


(Desulfovibrio
vulgaris;
Homo sapiens)
PF00258
(Flavodoxin_1)
PF01392
(Fz)
PF01534
(Frizzled)
4 LEU A 221
PHE A 222
SER A 385
GLU A 226
836  A1201 (-4.8A)
None
None
None
1.06A 5n5dA-5v57A:
undetectable
5n5dA-5v57A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 MAJOR CAPSID PROTEIN

(Escherichia
virus T4)
PF07068
(Gp23)
4 PHE A 434
ILE A 425
ASP A 432
ASN A 384
None
1.00A 5n5dA-5vf3A:
undetectable
5n5dA-5vf3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgz 26S PROTEASOME
REGULATORY SUBUNIT 7
26S PROTEASOME
REGULATORY SUBUNIT 4


(Homo sapiens;
Homo sapiens)
no annotation
no annotation
4 LEU A 153
ILE B 115
GLU B 114
ASP B 118
None
1.05A 5n5dA-5vgzA:
undetectable
5n5dA-5vgzA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE


(Bifidobacterium
adolescentis)
no annotation 4 LEU A 471
SER A  78
ILE A 498
GLU A 468
None
0.97A 5n5dA-5wabA:
undetectable
5n5dA-5wabA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x00 NUCLEOSIDE
DIPHOSPHATE KINASE


(Vibrio cholerae)
no annotation 4 LEU A  63
SER A  69
ILE A  10
ASN A 114
None
0.90A 5n5dA-5x00A:
undetectable
5n5dA-5x00A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC


(Zea mays)
no annotation 4 LEU 4 178
SER 4 166
ILE 4 155
ASP 4 160
CHL  4 618 ( 3.8A)
None
CHL  1 601 (-4.1A)
CHL  4 608 (-3.8A)
1.04A 5n5dA-5zji4:
undetectable
5n5dA-5zji4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM


(Bacillus
subtilis)
no annotation 4 SER A  68
ILE A  84
GLU A  85
ASP A 133
SAM  A 302 (-2.7A)
SAM  A 302 ( 4.7A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.6A)
0.15A 5n5dA-5zw4A:
25.0
5n5dA-5zw4A:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-)
no annotation 4 LEU A 662
PHE A 663
SER A 690
ILE A 668
None
0.89A 5n5dA-6a91A:
undetectable
5n5dA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM


(Saccharomyces
cerevisiae)
no annotation 4 PHE A  19
SER A  29
ILE A 334
ASN A 327
None
0.94A 5n5dA-6c6lA:
undetectable
5n5dA-6c6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED


(Escherichia
coli;
Xenopus laevis)
no annotation 4 LEU A 194
PHE A 195
SER A 358
GLU A 199
None
1.00A 5n5dA-6d35A:
undetectable
5n5dA-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3


(Rattus rattus)
PF00043
(GST_C)
PF02798
(GST_N)
4 LEU A  19
PHE A 157
ILE A 162
ASN A  73
None
0.90A 5n5dA-6gswA:
undetectable
5n5dA-6gswA:
23.46