SIMILAR PATTERNS OF AMINO ACIDS FOR 5N4T_A_BEZA507

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dp2 RHODANESE

(Bos taurus) 		PF00581
(Rhodanese) 		3 THR A  93
HIS A 120
ASN A  91
 None
 0.64A 5n4tA-1dp2A:
0.0		 5n4tA-1dp2A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvg PEPTIDE METHIONINE
SULFOXIDE REDUCTASE

(Bos taurus) 		PF01625
(PMSR) 		3 THR A  89
HIS A  48
ASN A  53
 None
 0.90A 5n4tA-1fvgA:
undetectable		 5n4tA-1fvgA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3v CAPSID PROTEIN VP2

(Ungulate
protoparvovirus
1) 		PF00740
(Parvo_coat) 		3 THR A 194
HIS A 381
ASN A 462
 None
 0.98A 5n4tA-1k3vA:
0.0		 5n4tA-1k3vA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 THR A 309
HIS A  77
ASN A 313
 None
 0.93A 5n4tA-1mlzA:
0.2		 5n4tA-1mlzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n4k INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Mus musculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR) 		3 THR A 596
HIS A 600
ASN A 602
 None
 0.95A 5n4tA-1n4kA:
0.0		 5n4tA-1n4kA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p50 ARGININE KINASE

(Limulus
polyphemus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 THR A 166
HIS A 212
ASN A 213
 None
 1.00A 5n4tA-1p50A:
0.0		 5n4tA-1p50A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 THR A 138
HIS A 141
ASN A 135
 FLC  A 742 (-2.7A)
None
None
 1.00A 5n4tA-1po0A:
0.0		 5n4tA-1po0A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 THR A 461
HIS A 500
ASN A 459
 None
 0.84A 5n4tA-1po0A:
0.0		 5n4tA-1po0A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 THR A 450
HIS A 459
ASN A 518
 EPE  A1111 ( 4.6A)
EPE  A1111 (-4.7A)
None
 0.98A 5n4tA-1sb3A:
undetectable		 5n4tA-1sb3A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 THR A 297
HIS A  75
ASN A 301
 SO4  A1213 ( 4.7A)
None
None
 0.69A 5n4tA-1szsA:
2.7		 5n4tA-1szsA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uar RHODANESE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		3 THR A  80
HIS A 105
ASN A  78
 None
 0.80A 5n4tA-1uarA:
undetectable		 5n4tA-1uarA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 THR A 124
HIS A 319
ASN A 148
 None
 0.82A 5n4tA-1v59A:
undetectable		 5n4tA-1v59A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1

(Aquifex
aeolicus) 		PF00072
(Response_reg) 		3 THR A  73
HIS A  44
ASN A   2
 None
 1.00A 5n4tA-1zy2A:
undetectable		 5n4tA-1zy2A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		3 THR A 181
HIS A 209
ASN A  29
 None
 0.88A 5n4tA-2a30A:
undetectable		 5n4tA-2a30A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atz H. PYLORI PREDICTED
CODING REGION HP0184

(Helicobacter
pylori) 		PF08966
(DUF1882) 		3 THR A 103
HIS A 118
ASN A 101
 None
 0.83A 5n4tA-2atzA:
undetectable		 5n4tA-2atzA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE

(Klebsiella
pneumoniae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		3 THR A 339
HIS A 229
ASN A 337
 None
 1.00A 5n4tA-2bi7A:
undetectable		 5n4tA-2bi7A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cmh SPERMIDINE SYNTHASE

(Helicobacter
pylori) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 THR A 127
HIS A  96
ASN A 125
 None
 0.89A 5n4tA-2cmhA:
undetectable		 5n4tA-2cmhA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddh ACYL-COA OXIDASE

(Rattus
norvegicus) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 THR A 183
HIS A 215
ASN A 185
 None
 0.90A 5n4tA-2ddhA:
undetectable		 5n4tA-2ddhA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e54 ACETYLORNITHINE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00202
(Aminotran_3) 		3 THR A 268
HIS A  62
ASN A 272
 None
 0.77A 5n4tA-2e54A:
undetectable		 5n4tA-2e54A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh6 ACETYLORNITHINE
AMINOTRANSFERASE

(Aquifex
aeolicus) 		PF00202
(Aminotran_3) 		3 THR A 270
HIS A  62
ASN A 274
 None
 0.77A 5n4tA-2eh6A:
1.7		 5n4tA-2eh6A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 THR A 325
HIS A 252
ASN A 322
 None
 0.81A 5n4tA-2g3nA:
2.9		 5n4tA-2g3nA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 THR A 600
HIS A 682
ASN A 685
 None
 0.92A 5n4tA-2g5tA:
1.6		 5n4tA-2g5tA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu0 NONSTRUCTURAL
PROTEIN 2

(Rotavirus C) 		PF02509
(Rota_NS35) 		3 THR A 152
HIS A 110
ASN A 113
 None
 0.84A 5n4tA-2gu0A:
undetectable		 5n4tA-2gu0A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw0 REPLICASE

(Porcine
circovirus 2) 		PF02407
(Viral_Rep) 		3 THR A  20
HIS A  57
ASN A  22
 None
 0.70A 5n4tA-2hw0A:
undetectable		 5n4tA-2hw0A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 THR A  48
HIS A 400
ASN A 233
 None
 0.98A 5n4tA-2ibuA:
undetectable		 5n4tA-2ibuA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 THR X  36
HIS X 187
ASN X 186
 None
 0.89A 5n4tA-2iv2X:
undetectable		 5n4tA-2iv2X:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqc PENICILLIN V ACYLASE

(Bacillus
subtilis) 		PF02275
(CBAH) 		3 THR A 150
HIS A  13
ASN A 284
 None
 1.00A 5n4tA-2oqcA:
undetectable		 5n4tA-2oqcA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00121
(TIM) 		3 THR A  31
HIS A  57
ASN A  29
 None
 0.81A 5n4tA-2x2gA:
undetectable		 5n4tA-2x2gA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3h K5 LYASE

(Escherichia
virus K1-5) 		no annotation 3 THR A  90
HIS A  86
ASN A 112
 None
 0.95A 5n4tA-2x3hA:
undetectable		 5n4tA-2x3hA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE

(Homo sapiens) 		PF00198
(2-oxoacid_dh) 		3 THR A 476
HIS A 421
ASN A 409
 None
 0.99A 5n4tA-3b8kA:
undetectable		 5n4tA-3b8kA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs6 INNER MEMBRANE
PROTEIN OXAA

(Escherichia
coli) 		PF14849
(YidC_periplas) 		3 THR A 306
HIS A 267
ASN A 304
 None
None
PGE  A 338 (-3.4A)
 0.91A 5n4tA-3bs6A:
undetectable		 5n4tA-3bs6A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byi RHO GTPASE
ACTIVATING PROTEIN
15

(Homo sapiens) 		PF00620
(RhoGAP) 		3 THR A 445
HIS A 451
ASN A 447
 None
 0.95A 5n4tA-3byiA:
undetectable		 5n4tA-3byiA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 THR A 493
HIS A 438
ASN A 495
 None
 0.86A 5n4tA-3dkhA:
undetectable		 5n4tA-3dkhA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8p UNCHARACTERIZED
PROTEIN

(Shewanella
oneidensis) 		PF03061
(4HBT) 		3 THR A 127
HIS A 147
ASN A 148
 None
 1.00A 5n4tA-3e8pA:
undetectable		 5n4tA-3e8pA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5k RIBOSOME-INACTIVATIN
G PROTEIN
PD-L1/PD-L2

(Phytolacca
dioica) 		PF00161
(RIP) 		3 THR A 257
HIS A 215
ASN A 255
 None
 0.79A 5n4tA-3h5kA:
2.3		 5n4tA-3h5kA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis) 		PF01266
(DAO) 		3 THR A 237
HIS A  91
ASN A  92
 None
 0.86A 5n4tA-3if9A:
undetectable		 5n4tA-3if9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 3 THR B 608
HIS B 724
ASN B 723
 None
 0.97A 5n4tA-3iz3B:
undetectable		 5n4tA-3iz3B:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Bacillus
cytotoxicus) 		PF13377
(Peripla_BP_3) 		3 THR A 117
HIS A 276
ASN A 113
 None
None
MAL  A 501 (-3.4A)
 0.69A 5n4tA-3k4hA:
undetectable		 5n4tA-3k4hA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l1z UBIQUITIN
CONJUGATION FACTOR
E4 B

(Homo sapiens) 		PF04564
(U-box) 		3 THR B1267
HIS B1261
ASN B1264
 None
 0.90A 5n4tA-3l1zB:
undetectable		 5n4tA-3l1zB:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l60 BRANCHED-CHAIN
ALPHA-KETO ACID
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00198
(2-oxoacid_dh) 		3 THR A 239
HIS A 252
ASN A 237
 None
 0.89A 5n4tA-3l60A:
undetectable		 5n4tA-3l60A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 THR A 508
HIS A 310
ASN A 510
 None
None
FDA  A 547 (-4.6A)
 0.85A 5n4tA-3ljpA:
undetectable		 5n4tA-3ljpA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE

(Listeria
monocytogenes) 		PF00198
(2-oxoacid_dh) 		3 THR A 265
HIS A 274
ASN A 263
 GOL  A 425 ( 4.7A)
GOL  A 425 (-3.5A)
None
 0.96A 5n4tA-3maeA:
undetectable		 5n4tA-3maeA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 THR A 200
HIS A  96
ASN A 244
 AZM  A 264 (-3.5A)
ZN  A 263 ( 3.2A)
None
 1.01A 5n4tA-3ml5A:
undetectable		 5n4tA-3ml5A:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9o PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF02373
(JmjC) 		3 THR A 205
HIS A 252
ASN A 237
 None
ZN  A   2 (-3.2A)
None
 0.99A 5n4tA-3n9oA:
undetectable		 5n4tA-3n9oA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		3 THR A 321
HIS A  91
ASN A 325
 None
 0.70A 5n4tA-3oksA:
1.3		 5n4tA-3oksA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om5 LEVANSUCRASE

(Bacillus
megaterium) 		PF02435
(Glyco_hydro_68) 		3 THR A 237
HIS A 253
ASN A 274
 None
None
CA  A   1 ( 4.8A)
 0.90A 5n4tA-3om5A:
undetectable		 5n4tA-3om5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		3 THR A 248
HIS A 167
ASN A 246
 None
 0.94A 5n4tA-3p27A:
undetectable		 5n4tA-3p27A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8n 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		3 THR A 322
HIS A  98
ASN A 326
 None
 0.71A 5n4tA-3q8nA:
1.7		 5n4tA-3q8nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk3 BETA-CRYSTALLIN B3

(Homo sapiens) 		PF00030
(Crystall) 		3 THR A 157
HIS A 114
ASN A 155
 None
None
SO4  A   2 (-4.9A)
 0.94A 5n4tA-3qk3A:
undetectable		 5n4tA-3qk3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT

(Mycobacterium
marinum) 		PF00202
(Aminotran_3) 		3 THR A 320
HIS A  90
ASN A 324
 None
 0.72A 5n4tA-3r4tA:
undetectable		 5n4tA-3r4tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rev TCR NB20 ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 THR A  25
HIS A  76
ASN A  69
 None
 0.94A 5n4tA-3revA:
undetectable		 5n4tA-3revA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3riq TAILSPIKE PROTEIN

(Salmonella
virus 9NA) 		PF09251
(PhageP22-tail) 		3 THR A 294
HIS A 214
ASN A 313
 None
 0.90A 5n4tA-3riqA:
undetectable		 5n4tA-3riqA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 3 THR A 217
HIS A 201
ASN A 173
 None
 0.94A 5n4tA-3sbqA:
undetectable		 5n4tA-3sbqA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 THR A 199
HIS A  96
ASN A 243
 None
ZN  A 261 (-3.3A)
None
 0.98A 5n4tA-3uyqA:
undetectable		 5n4tA-3uyqA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ade SUCCINYLORNITHINE
TRANSAMINASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 THR A 281
HIS A  73
ASN A 285
 None
 0.77A 5n4tA-4adeA:
undetectable		 5n4tA-4adeA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atq 4-AMINOBUTYRATE
TRANSAMINASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		3 THR A 324
HIS A  98
ASN A 328
 None
 0.67A 5n4tA-4atqA:
1.7		 5n4tA-4atqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhl ARGININE KINASE

(Litopenaeus
vannamei) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 THR A 166
HIS A 212
ASN A 213
 None
 0.93A 5n4tA-4bhlA:
undetectable		 5n4tA-4bhlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db1 MYOSIN-7

(Homo sapiens) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 THR A 481
HIS A 651
ASN A 654
 None
 0.89A 5n4tA-4db1A:
undetectable		 5n4tA-4db1A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)

(Mycobacteroides
abscessus) 		PF00202
(Aminotran_3) 		3 THR A 319
HIS A  94
ASN A 323
 None
 0.71A 5n4tA-4ffcA:
undetectable		 5n4tA-4ffcA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE

(Parabacteroides
distasonis) 		PF13859
(BNR_3)
PF14873
(BNR_assoc_N) 		3 THR A 252
HIS A 261
ASN A 264
 None
PO4  A 605 (-3.6A)
None
 0.87A 5n4tA-4fj6A:
undetectable		 5n4tA-4fj6A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hku TETR TRANSCRIPTIONAL
REGULATOR

(Listeria
monocytogenes) 		PF00440
(TetR_N) 		3 THR A 144
HIS A 150
ASN A 151
 None
 0.88A 5n4tA-4hkuA:
undetectable		 5n4tA-4hkuA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 THR A 165
HIS A 304
ASN A 396
 None
 0.98A 5n4tA-4jb6A:
undetectable		 5n4tA-4jb6A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 THR A  97
HIS A 127
ASN A 128
 None
 1.01A 5n4tA-4jr7A:
undetectable		 5n4tA-4jr7A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jvu IG MU CHAIN C REGION
MEMBRANE-BOUND FORM

(Mus musculus) 		PF07654
(C1-set) 		3 THR A 263
HIS A 324
ASN A 232
 None
 0.62A 5n4tA-4jvuA:
undetectable		 5n4tA-4jvuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lut ALANINE RACEMASE

(Clostridioides
difficile) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 THR A 343
HIS A 231
ASN A 355
 None
 1.01A 5n4tA-4lutA:
2.1		 5n4tA-4lutA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 THR A 151
HIS A 156
ASN A 149
 None
 0.99A 5n4tA-4okdA:
undetectable		 5n4tA-4okdA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		3 THR A 481
HIS A 651
ASN A 654
 None
 0.99A 5n4tA-4p7hA:
undetectable		 5n4tA-4p7hA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwv P450 MONOOXYGENASE

(Streptomyces
sp. Acta 2897) 		PF00067
(p450) 		3 THR A  98
HIS A 355
ASN A  78
 None
HEM  A 501 (-3.7A)
HEM  A 501 (-3.9A)
 0.80A 5n4tA-4pwvA:
undetectable		 5n4tA-4pwvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		3 THR A 746
HIS A 531
ASN A 748
 None
None
FAD  A 901 (-4.2A)
 0.84A 5n4tA-4qi4A:
undetectable		 5n4tA-4qi4A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		3 THR A 746
HIS A 531
ASN A 748
 None
None
FAD  A 902 (-4.5A)
 0.87A 5n4tA-4qi6A:
undetectable		 5n4tA-4qi6A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE

(Neurospora
crassa) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		3 THR A 745
HIS A 530
ASN A 747
 None
None
FAD  A 902 (-3.8A)
 0.81A 5n4tA-4qi7A:
undetectable		 5n4tA-4qi7A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 THR A 200
HIS A  96
ASN A 233
 None
ZN  A 301 (-3.2A)
None
 0.97A 5n4tA-4qk3A:
undetectable		 5n4tA-4qk3A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8g UNCONVENTIONAL
MYOSIN-IC

(Mus musculus) 		PF00612
(IQ)
PF06017
(Myosin_TH1) 		3 THR E 989
HIS E 945
ASN E 982
 None
 0.97A 5n4tA-4r8gE:
undetectable		 5n4tA-4r8gE:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1b LMO1466 PROTEIN

(Listeria
monocytogenes) 		PF01966
(HD) 		3 THR A 661
HIS A 708
ASN A 704
 None
 0.80A 5n4tA-4s1bA:
undetectable		 5n4tA-4s1bA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trg SIDC

(Legionella
pneumophila) 		no annotation 3 THR A 232
HIS A 236
ASN A 258
 None
 0.86A 5n4tA-4trgA:
undetectable		 5n4tA-4trgA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 THR A 509
HIS A 307
ASN A 511
 None
None
FAD  A 700 (-4.7A)
 0.78A 5n4tA-4udrA:
undetectable		 5n4tA-4udrA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		3 THR A 318
HIS A  89
ASN A 322
 None
 0.90A 5n4tA-4w1wA:
2.9		 5n4tA-4w1wA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woe TAUROCYAMINE KINASE

(Schistosoma
mansoni) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 THR A 526
HIS A 572
ASN A 573
 None
 0.96A 5n4tA-4woeA:
undetectable		 5n4tA-4woeA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x09 RIBONUCLEASE K6

(Homo sapiens) 		PF00074
(RnaseA) 		3 THR A  79
HIS A  45
ASN A  77
 None
 0.93A 5n4tA-4x09A:
undetectable		 5n4tA-4x09A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I

(Oryctolagus
cuniculus) 		PF00400
(WD40) 		3 THR I 213
HIS I 195
ASN I 219
 None
 0.94A 5n4tA-5a5uI:
undetectable		 5n4tA-5a5uI:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aca VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 THR 1 113
HIS 1  84
ASN 1 111
 None
 0.87A 5n4tA-5aca1:
undetectable		 5n4tA-5aca1:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		3 THR X 198
HIS X  95
ASN X 242
 None
ZN  X 301 (-3.2A)
None
 0.97A 5n4tA-5eztX:
undetectable		 5n4tA-5eztX:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkc BETA-FRUCTOFURANOSID
ASE

(Xanthophyllomyces
dendrorhous) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 THR A 173
HIS A 256
ASN A 175
 None
None
NAG  A1215 (-3.3A)
 0.99A 5n4tA-5fkcA:
undetectable		 5n4tA-5fkcA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyq SPIKE GLYCOPROTEIN

(Rousettus bat
coronavirus
HKU9) 		PF09408
(Spike_rec_bind) 		3 THR A  88
HIS A  77
ASN A  80
 NAG  A 802 ( 3.9A)
NAG  A 801 (-4.3A)
None
 0.94A 5n4tA-5gyqA:
undetectable		 5n4tA-5gyqA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iku COLLAGENASE

(Hathewaya
histolytica) 		PF04151
(PPC) 		3 THR A 836
HIS A 877
ASN A 834
 None
 0.81A 5n4tA-5ikuA:
undetectable		 5n4tA-5ikuA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrm ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00457
(Glyco_hydro_11) 		3 THR A  21
HIS A  45
ASN A  44
 SO4  A 202 (-4.3A)
None
None
 0.92A 5n4tA-5jrmA:
undetectable		 5n4tA-5jrmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 3 THR A 249
HIS A 233
ASN A 251
 None
 0.89A 5n4tA-5n6vA:
undetectable		 5n4tA-5n6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o75 UBIQUITIN
CONJUGATION FACTOR
E4 B

(Homo sapiens) 		no annotation 3 THR A1138
HIS A1132
ASN A1135
 None
 0.95A 5n4tA-5o75A:
undetectable		 5n4tA-5o75A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oki SISTER CHROMATID
COHESION PROTEIN
DCC1

(Saccharomyces
cerevisiae) 		no annotation 3 THR C 104
HIS C  65
ASN C  67
 None
 0.97A 5n4tA-5okiC:
undetectable		 5n4tA-5okiC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE

(Azospirillum
brasilense) 		no annotation 3 THR A 157
HIS A 123
ASN A 160
 None
 0.93A 5n4tA-5ovoA:
undetectable		 5n4tA-5ovoA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgg RADICAL SAM DOMAIN
PROTEIN

(Ruminiclostridium
thermocellum) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12) 		3 THR A 354
HIS A 102
ASN A 123
 None
 0.74A 5n4tA-5wggA:
undetectable		 5n4tA-5wggA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnw ADENYLATE CYCLASE
EXOY

(Pseudomonas
aeruginosa) 		no annotation 3 THR A 113
HIS A 104
ASN A 120
 None
 0.95A 5n4tA-5xnwA:
undetectable		 5n4tA-5xnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0k IOTA-CARRAGEENAN
SULFATASE

(Pseudoalteromonas) 		no annotation 3 THR A 186
HIS A 159
ASN A 160
 None
 0.89A 5n4tA-6b0kA:
undetectable		 5n4tA-6b0kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5v TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5

(Oryctolagus
cuniculus) 		no annotation 3 THR A 198
HIS A 201
ASN A 237
 None
 0.94A 5n4tA-6b5vA:
undetectable		 5n4tA-6b5vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 3 THR A  30
HIS A 216
ASN A 214
 None
None
CA  A 401 (-3.0A)
 0.85A 5n4tA-6bk5A:
undetectable		 5n4tA-6bk5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 3 THR A 826
HIS A  57
ASN A1311
 None
 0.77A 5n4tA-6eojA:
undetectable		 5n4tA-6eojA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 3 THR B 947
HIS B 867
ASN B 890
 None
None
SF4  B1102 (-3.7A)
 1.00A 5n4tA-6f0kB:
undetectable		 5n4tA-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 3 THR A 716
HIS A 694
ASN A 670
 None
 0.86A 5n4tA-6fnwA:
undetectable		 5n4tA-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-) 		no annotation 3 THR A 481
HIS A 651
ASN A 654
 None
 0.92A 5n4tA-6fsaA:
undetectable		 5n4tA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 3 THR A 716
HIS A 694
ASN A 670
 None
 0.88A 5n4tA-6g9oA:
undetectable		 5n4tA-6g9oA:
undetectable