SIMILAR PATTERNS OF AMINO ACIDS FOR 5N3H_A_NCAA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  70
VAL A  78
ALA A  91
MET A 138
LEU A 193
THR A 206
 STU  A 401 (-3.9A)
STU  A 401 (-4.7A)
STU  A 401 (-3.4A)
STU  A 401 (-3.2A)
STU  A 401 (-4.7A)
STU  A 401 (-3.2A)
 0.80A 5n3hA-1nxkA:
22.0		 5n3hA-1nxkA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  70
VAL A  78
ALA A  91
VAL A 118
MET A 138
THR A 206
 STU  A 401 (-3.9A)
STU  A 401 (-4.7A)
STU  A 401 (-3.4A)
None
STU  A 401 (-3.2A)
STU  A 401 (-3.2A)
 0.66A 5n3hA-1nxkA:
22.0		 5n3hA-1nxkA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
VAL A 603
ALA A 621
VAL A 654
TYR A 672
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
 0.48A 5n3hA-1t46A:
21.9		 5n3hA-1t46A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 344
VAL A 352
ALA A 367
VAL A 399
MET A 414
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.6A)
STU  A 100 (-4.5A)
 0.66A 5n3hA-1u59A:
24.3		 5n3hA-1u59A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
VAL A  68
TYR A  86
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
 0.66A 5n3hA-1zltA:
26.1		 5n3hA-1zltA:
26.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 259
ALA A 272
VAL A 307
TYR A 325
VAL A 326
LEU A 376
THR A 386
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-4.4A)
BI1  A1000 (-4.2A)
BI1  A1000 (-3.9A)
BI1  A1000 (-4.8A)
BI1  A1000 (-3.2A)
 0.81A 5n3hA-1zrzA:
36.4		 5n3hA-1zrzA:
36.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A 605
VAL A 613
ALA A 626
VAL A 656
MET A 788
TYR A 790
 None
None
GOL  A 998 ( 3.7A)
GOL  A 998 (-4.9A)
GOL  A 998 ( 4.2A)
GOL  A 998 (-4.6A)
 0.77A 5n3hA-1zy4A:
21.5		 5n3hA-1zy4A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
VAL X  25
ALA X  37
VAL X  67
TYR X  84
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
 0.68A 5n3hA-2dq7X:
25.7		 5n3hA-2dq7X:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
ALA A 293
VAL A 323
TYR A 340
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-4.3A)
H8H  A 534 (-4.5A)
 0.76A 5n3hA-2h8hA:
22.2		 5n3hA-2h8hA:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 348
VAL A 356
ALA A 369
MET A 420
TYR A 422
VAL A 423
 PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 ( 4.8A)
PDS  A 901 (-4.7A)
PDS  A 901 (-4.3A)
 0.54A 5n3hA-2i0eA:
37.5		 5n3hA-2i0eA:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  29
VAL A  37
ALA A  50
VAL A  82
MET A  98
VAL A 101
 J60  A1305 (-3.9A)
J60  A1305 (-4.8A)
J60  A1305 (-3.3A)
J60  A1305 ( 4.7A)
EDO  A1304 (-4.6A)
J60  A1305 (-3.9A)
 0.68A 5n3hA-2jamA:
20.1		 5n3hA-2jamA:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
ALA A 271
VAL A 301
TYR A 318
LEU A 371
 None
None
1N8  A 501 ( 3.4A)
None
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.3A)
 0.79A 5n3hA-2og8A:
21.5		 5n3hA-2og8A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 588
VAL A 596
ALA A 614
VAL A 647
TYR A 665
LEU A 785
 None
 0.71A 5n3hA-2ogvA:
20.8		 5n3hA-2ogvA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 LEU A 344
VAL A 352
ALA A 367
VAL A 399
MET A 414
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.83A 5n3hA-2ozoA:
19.7		 5n3hA-2ozoA:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU X  70
VAL X  78
ALA X  91
MET X 138
LEU X 193
THR X 206
 F10  X 401 (-3.9A)
None
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
F10  X 401 ( 4.4A)
F10  X 401 (-3.8A)
 0.82A 5n3hA-2p3gX:
20.0		 5n3hA-2p3gX:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU X  70
VAL X  78
ALA X  91
VAL X 118
MET X 138
THR X 206
 F10  X 401 (-3.9A)
None
F10  X 401 (-3.4A)
None
F10  X 401 ( 4.0A)
F10  X 401 (-3.8A)
 0.59A 5n3hA-2p3gX:
20.0		 5n3hA-2p3gX:
30.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		6 VAL B  55
ALA B  67
VAL B  98
TYR B 116
LEU B 171
THR B 181
 None
 0.67A 5n3hA-2qkwB:
22.9		 5n3hA-2qkwB:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 724
VAL A 732
ALA A 749
VAL A 781
LEU A 850
THR A 860
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
 0.49A 5n3hA-2r4bA:
10.4		 5n3hA-2r4bA:
24.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  90
ALA A 103
VAL A 137
MET A 153
TYR A 155
LEU A 205
PHE A 368
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.7A)
ANP  A1480 (-4.1A)
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
ANP  A1480 (-4.5A)
 0.72A 5n3hA-2v55A:
35.2		 5n3hA-2v55A:
34.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU C  55
VAL C  63
ALA C  76
MET C 129
TYR C 131
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
 0.69A 5n3hA-2wtkC:
29.9		 5n3hA-2wtkC:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 112
VAL A 120
ALA A 133
MET A 180
TYR A 182
VAL A 183
LEU A 234
 16X  A1374 (-4.1A)
16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
16X  A1374 (-4.2A)
16X  A1374 (-4.1A)
16X  A1374 (-4.0A)
16X  A1374 ( 4.8A)
 0.93A 5n3hA-2x4fA:
26.0		 5n3hA-2x4fA:
25.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  68
VAL A  76
ALA A  92
VAL A 125
LEU A 194
THR A 204
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
STU  A   1 (-3.6A)
 0.52A 5n3hA-2z7rA:
29.7		 5n3hA-2z7rA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  97
VAL A 105
ALA A 121
VAL A 156
TYR A 174
THR A 235
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
None
STU  A 400 (-4.7A)
STU  A 400 (-4.4A)
 0.70A 5n3hA-3a62A:
32.1		 5n3hA-3a62A:
35.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
MET A 117
TYR A 119
LEU A 173
 DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
DRK  A 384 (-3.8A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
 0.70A 5n3hA-3eb0A:
25.7		 5n3hA-3eb0A:
25.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 VAL A  70
ALA A  83
VAL A 116
MET A 132
TYR A 134
LEU A 185
 None
 0.84A 5n3hA-3fe3A:
21.1		 5n3hA-3fe3A:
32.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 431
VAL A 439
ALA A 455
VAL A 487
MET A 502
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
None
AGS  A 999 (-4.5A)
 0.77A 5n3hA-3fzpA:
22.0		 5n3hA-3fzpA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 112
ALA A 125
VAL A 160
TYR A 178
LEU A 229
THR A 239
 None
GMG  A   1 (-3.4A)
None
GMG  A   1 ( 4.9A)
GMG  A   1 ( 4.9A)
GMG  A   1 (-3.8A)
 0.76A 5n3hA-3hdnA:
29.6		 5n3hA-3hdnA:
39.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 833
VAL A 841
ALA A 859
VAL A 892
TYR A 911
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
 0.60A 5n3hA-3hngA:
22.0		 5n3hA-3hngA:
22.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 VAL A  67
ALA A  80
VAL A 113
MET A 129
TYR A 131
LEU A 182
 None
 0.75A 5n3hA-3iecA:
29.4		 5n3hA-3iecA:
32.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 171
VAL A 179
ALA A 192
VAL A 224
TYR A 242
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.2A)
 0.64A 5n3hA-3mtlA:
24.0		 5n3hA-3mtlA:
27.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  49
VAL A  57
ALA A  70
VAL A 104
MET A 120
TYR A 122
VAL A 123
LEU A 173
THR A 183
PHE A 327
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.2A)
XFE  A 351 (-4.6A)
XFE  A 351 (-3.7A)
XFE  A 351 (-4.4A)
 0.54A 5n3hA-3mvjA:
53.3		 5n3hA-3mvjA:
93.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
VAL A  96
ALA A 109
VAL A 143
TYR A 161
LEU A 212
THR A 222
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
None
None
None
JOZ  A 361 (-3.7A)
 0.68A 5n3hA-3nuuA:
35.0		 5n3hA-3nuuA:
34.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		6 LEU A 348
VAL A 356
ALA A 369
MET A 420
TYR A 422
VAL A 423
 ANP  A 800 ( 4.4A)
ANP  A 800 ( 4.7A)
ANP  A 800 (-3.6A)
ANP  A 800 (-4.8A)
ANP  A 800 (-4.2A)
ANP  A 800 (-4.0A)
 0.49A 5n3hA-3pfqA:
37.1		 5n3hA-3pfqA:
23.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  90
ALA A 103
MET A 153
TYR A 155
LEU A 207
PHE A 370
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
NM7  A 416 (-3.6A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
NM7  A 416 (-3.3A)
 0.48A 5n3hA-3qfvA:
35.8		 5n3hA-3qfvA:
33.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  50
VAL A  58
ALA A  71
VAL A  98
MET A 118
LEU A 173
THR A 186
 I85  A 350 (-3.7A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
None
I85  A 350 ( 3.9A)
None
I85  A 350 ( 4.0A)
 0.75A 5n3hA-3sheA:
20.4		 5n3hA-3sheA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 423
VAL A 431
ALA A 443
VAL A 473
TYR A 491
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
None
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.42A 5n3hA-3sxsA:
17.9		 5n3hA-3sxsA:
25.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 361
VAL A 369
ALA A 382
MET A 433
VAL A 436
LEU A 486
PHE A 644
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.3A)
07U  A   1 (-3.8A)
07U  A   1 (-4.3A)
None
 0.57A 5n3hA-3txoA:
24.7		 5n3hA-3txoA:
38.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 544
VAL A 552
ALA A 570
VAL A 601
TYR A 619
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.2A)
0F4  A 902 (-4.5A)
 0.56A 5n3hA-3v5qA:
21.1		 5n3hA-3v5qA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  75
VAL A  83
ALA A  96
VAL A 128
MET A 144
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 (-4.8A)
 0.84A 5n3hA-3wigA:
24.2		 5n3hA-3wigA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 560
VAL A 568
ALA A 586
VAL A 617
TYR A 635
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
LTI  A1839 (-4.2A)
 0.75A 5n3hA-4at3A:
21.6		 5n3hA-4at3A:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A  91
ALA A 104
MET A 154
TYR A 156
LEU A 208
PHE A 371
 None
EDO  A1420 (-3.4A)
None
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
EDO  A1420 ( 4.6A)
 0.39A 5n3hA-4aw2A:
36.5		 5n3hA-4aw2A:
30.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  40
VAL A  73
TYR A  91
VAL A  92
LEU A 142
 38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
None
38R  A1000 (-4.8A)
38R  A1000 (-4.1A)
38R  A1000 ( 4.5A)
 0.44A 5n3hA-4bgqA:
25.6		 5n3hA-4bgqA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		6 LEU A 246
VAL A 254
ALA A 267
TYR A 320
LEU A 371
THR A 381
 None
 0.56A 5n3hA-4c0tA:
30.6		 5n3hA-4c0tA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-3.8A)
STU  A1550 (-4.3A)
 0.70A 5n3hA-4cfhA:
31.5		 5n3hA-4cfhA:
24.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
VAL A 671
ALA A 684
VAL A 721
MET A 737
TYR A 739
LEU A 789
PHE A 946
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
AGS  A1985 (-4.8A)
 0.61A 5n3hA-4crsA:
39.0		 5n3hA-4crsA:
40.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		7 LEU A  16
VAL A  24
ALA A  37
VAL A  71
MET A  87
TYR A  89
LEU A 140
 ANP  A 300 (-4.7A)
ANP  A 300 ( 4.7A)
ANP  A 300 ( 3.8A)
None
ANP  A 300 (-3.6A)
ANP  A 300 (-4.3A)
ANP  A 300 (-4.7A)
 0.74A 5n3hA-4eqmA:
25.3		 5n3hA-4eqmA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
VAL A  68
MET A  86
THR A 156
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
BX7  A 401 (-4.5A)
IOD  A 402 ( 3.4A)
 0.73A 5n3hA-4eutA:
14.2		 5n3hA-4eutA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
VAL A  68
MET A  86
THR A 156
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
BX7  A 401 (-3.7A)
IOD  A 402 ( 3.5A)
 0.70A 5n3hA-4euuA:
26.1		 5n3hA-4euuA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 515
VAL A 523
ALA A 541
VAL A 572
TYR A 590
LEU A 656
 None
 0.80A 5n3hA-4f0iA:
15.0		 5n3hA-4f0iA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 377
VAL A 385
ALA A 400
VAL A 433
MET A 448
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
0SB  A 701 (-3.6A)
0SB  A 701 (-4.4A)
 0.69A 5n3hA-4f4pA:
23.6		 5n3hA-4f4pA:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  26
VAL A  34
ALA A  47
MET A  95
VAL A  98
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 ( 4.3A)
ATP  A 401 (-3.9A)
ATP  A 401 (-4.6A)
 0.82A 5n3hA-4fg8A:
24.1		 5n3hA-4fg8A:
30.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 LEU A 377
VAL A 385
ALA A 400
VAL A 433
MET A 448
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 3.7A)
ANP  A 701 (-4.5A)
 0.78A 5n3hA-4fl3A:
21.1		 5n3hA-4fl3A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
VAL A 863
ALA A 880
VAL A 911
MET A 929
TYR A 931
LEU A 983
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
None
IZA  A2001 (-4.4A)
None
IZA  A2001 ( 4.7A)
 0.69A 5n3hA-4gl9A:
24.0		 5n3hA-4gl9A:
25.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 156
VAL A 164
ALA A 177
MET A 227
TYR A 229
THR A 291
PHE A 438
 0XZ  A 501 ( 4.1A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
0XZ  A 501 (-3.8A)
0XZ  A 501 ( 4.9A)
0XZ  A 501 ( 4.1A)
0XZ  A 501 (-4.8A)
 0.51A 5n3hA-4gv1A:
41.5		 5n3hA-4gv1A:
39.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
VAL A 836
ALA A 853
VAL A 884
MET A 902
TYR A 904
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
19S  A1201 (-3.6A)
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
 0.53A 5n3hA-4hviA:
24.8		 5n3hA-4hviA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
VAL A  68
MET A  86
THR A 156
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
None
SU6  A 701 (-3.4A)
SU6  A 701 (-3.5A)
 0.72A 5n3hA-4jlcA:
17.4		 5n3hA-4jlcA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
ALA A 293
VAL A 323
TYR A 340
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
None
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.5A)
 0.69A 5n3hA-4k11A:
21.7		 5n3hA-4k11A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A  50
ALA A  61
VAL A  90
MET A 104
TYR A 106
LEU A 163
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-3.6A)
1UL  A 501 (-4.1A)
1UL  A 501 (-4.3A)
 0.60A 5n3hA-4l52A:
22.9		 5n3hA-4l52A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  33
VAL A  41
ALA A  54
VAL A  83
MET A  99
LEU A 153
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 (-4.1A)
GOL  A 403 (-2.7A)
GOL  A 403 ( 4.4A)
 0.83A 5n3hA-4lg4A:
24.6		 5n3hA-4lg4A:
29.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  33
VAL A  41
ALA A  54
VAL A  83
MET A  99
TYR A 101
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 (-4.1A)
GOL  A 403 (-2.7A)
GOL  A 404 ( 4.9A)
 0.54A 5n3hA-4lg4A:
24.6		 5n3hA-4lg4A:
29.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
ALA A 293
VAL A 323
TYR A 340
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 (-4.5A)
 0.72A 5n3hA-4lggA:
20.6		 5n3hA-4lggA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
VAL A 911
ALA A 928
TYR A 980
VAL A 981
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
2TT  A1202 (-3.7A)
2TT  A1202 (-4.4A)
 0.64A 5n3hA-4oliA:
23.9		 5n3hA-4oliA:
19.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 627
VAL A 635
ALA A 648
VAL A 685
MET A 701
TYR A 703
 None
 0.79A 5n3hA-4otdA:
39.8		 5n3hA-4otdA:
36.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 627
VAL A 635
ALA A 648
VAL A 685
TYR A 703
LEU A 753
PHE A 910
 None
 0.68A 5n3hA-4otdA:
39.8		 5n3hA-4otdA:
36.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pds SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 VAL A 212
VAL A 257
MET A 273
VAL A 276
LEU A 326
THR A 338
 ANP  A 601 (-4.4A)
None
ANP  A 601 (-4.3A)
ANP  A 601 (-4.3A)
ANP  A 601 (-4.7A)
ANP  A 601 ( 4.4A)
 0.72A 5n3hA-4pdsA:
11.5		 5n3hA-4pdsA:
28.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 386
VAL A 394
ALA A 407
MET A 458
TYR A 460
LEU A 511
PHE A 664
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.8A)
PZW  A 801 (-4.3A)
 0.68A 5n3hA-4q9zA:
39.7		 5n3hA-4q9zA:
37.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 345
VAL A 353
ALA A 366
MET A 417
TYR A 419
VAL A 420
 3KZ  A 701 ( 4.1A)
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
3KZ  A 701 (-4.2A)
None
3KZ  A 701 (-4.1A)
 0.67A 5n3hA-4ra4A:
38.2		 5n3hA-4ra4A:
36.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  24
VAL A  32
ALA A  45
MET A  95
TYR A  97
VAL A  98
 None
 0.48A 5n3hA-4redA:
22.0		 5n3hA-4redA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  24
VAL A  32
ALA A  45
MET A  95
TYR A  97
VAL A  98
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.3A)
STU  A 601 (-4.4A)
STU  A 601 (-4.1A)
STU  A 601 (-4.2A)
 0.61A 5n3hA-4rewA:
31.2		 5n3hA-4rewA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
VAL A 624
ALA A 642
VAL A 675
TYR A 693
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
 0.52A 5n3hA-4rt7A:
16.1		 5n3hA-4rt7A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
VAL A  22
ALA A  35
VAL A  65
TYR A  83
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
 0.59A 5n3hA-4ueuA:
24.7		 5n3hA-4ueuA:
23.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		10 LEU A 104
VAL A 112
ALA A 125
VAL A 159
MET A 175
TYR A 177
VAL A 178
LEU A 228
THR A 238
PHE A 382
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.2A)
ATP  A 501 (-4.5A)
ATP  A 501 (-3.1A)
ATP  A 501 (-4.5A)
 0.57A 5n3hA-4wb7A:
53.1		 5n3hA-4wb7A:
83.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
VAL A 201
ALA A 214
VAL A 248
MET A 264
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
ANW  A 601 (-3.2A)
ANW  A 601 (-4.9A)
 0.51A 5n3hA-4wboA:
36.9		 5n3hA-4wboA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  52
VAL A  60
ALA A  72
VAL A 104
MET A 126
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 ( 3.7A)
KSA  A 405 (-4.6A)
 0.41A 5n3hA-4wsqA:
26.0		 5n3hA-4wsqA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
VAL A 624
ALA A 642
VAL A 675
TYR A 693
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
 0.45A 5n3hA-4xufA:
14.7		 5n3hA-4xufA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		6 LEU A 408
VAL A 416
ALA A 428
VAL A 458
TYR A 476
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-4.4A)
746  A 702 (-4.4A)
 0.69A 5n3hA-4y93A:
21.9		 5n3hA-4y93A:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
ALA A  44
VAL A  76
MET A  92
TYR A  94
LEU A 145
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.9A)
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
 0.50A 5n3hA-5ci7A:
28.6		 5n3hA-5ci7A:
30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
VAL A 911
ALA A 928
MET A 978
TYR A 980
VAL A 981
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.4A)
 0.57A 5n3hA-5f1zA:
24.3		 5n3hA-5f1zA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
VAL A 607
ALA A 625
VAL A 658
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.52A 5n3hA-5grnA:
14.7		 5n3hA-5grnA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 LEU A  20
VAL A  28
ALA A  41
VAL A  74
VAL A  93
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.0A)
ADP  A 301 (-4.7A)
 0.54A 5n3hA-5hu3A:
30.5		 5n3hA-5hu3A:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  57
VAL A  65
ALA A  77
VAL A 109
MET A 130
TYR A 132
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.63A 5n3hA-5i3oA:
25.8		 5n3hA-5i3oA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.0A)
STU  A 601 (-4.5A)
 0.61A 5n3hA-5isoA:
31.0		 5n3hA-5isoA:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 404
ALA A 417
VAL A 449
MET A 465
VAL A 468
LEU A 518
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.0A)
GUI  A 701 (-4.4A)
 0.55A 5n3hA-5jznA:
29.3		 5n3hA-5jznA:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 284
ALA A 297
VAL A 328
MET A 344
TYR A 346
LEU A 396
THR A 406
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
None
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.77A 5n3hA-5kbrA:
26.6		 5n3hA-5kbrA:
26.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  49
ALA A  60
VAL A  94
MET A 110
TYR A 112
LEU A 163
THR A 173
 None
STU  A 901 (-3.3A)
None
STU  A 901 (-3.7A)
STU  A 901 (-4.6A)
STU  A 901 (-4.5A)
STU  A 901 (-3.5A)
 0.65A 5n3hA-5lohA:
29.2		 5n3hA-5lohA:
34.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		6 LEU A  18
VAL A  26
ALA A  39
MET A  89
TYR A  91
VAL A  92
 None
 0.62A 5n3hA-5m09A:
20.1		 5n3hA-5m09A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 6 VAL A 366
ALA A 379
VAL A 413
MET A 429
LEU A 482
PHE A 700
 ANP  A 801 (-4.7A)
ANP  A 801 ( 3.9A)
ANP  A 801 ( 4.9A)
ANP  A 801 ( 4.5A)
ANP  A 801 (-4.8A)
ANP  A 801 (-4.4A)
 0.83A 5n3hA-5nclA:
29.8		 5n3hA-5nclA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 106
ALA A 119
VAL A 153
MET A 169
TYR A 171
LEU A 221
PHE A 384
 None
 0.56A 5n3hA-5u7qA:
36.6		 5n3hA-5u7qA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 7 LEU A  17
VAL A  25
ALA A  38
VAL A  72
MET A  92
TYR A  94
VAL A  95
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-4.0A)
G93  A 301 (-2.7A)
None
G93  A 301 (-4.1A)
 0.73A 5n3hA-5u94A:
27.9		 5n3hA-5u94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 6 LEU A 686
VAL A 694
ALA A 707
MET A 754
VAL A 757
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.9A)
9E1  A1001 (-4.5A)
 0.60A 5n3hA-5vilA:
22.6		 5n3hA-5vilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 6 VAL A 694
ALA A 707
VAL A 738
MET A 754
VAL A 757
LEU A 810
 9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-4.1A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.9A)
9E1  A1001 (-4.5A)
 0.50A 5n3hA-5vilA:
22.6		 5n3hA-5vilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 LEU A 891
VAL A 899
ALA A 917
TYR A 965
LEU A1017
THR A1027
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
 0.45A 5n3hA-5wnoA:
20.9		 5n3hA-5wnoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 7 VAL A 212
ALA A 225
VAL A 257
MET A 273
VAL A 276
LEU A 326
THR A 338
 None
 0.87A 5n3hA-5xzwA:
22.5		 5n3hA-5xzwA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 LEU A  33
VAL A  41
ALA A  54
VAL A  83
TYR A 101
LEU A 153
 ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
None
ANP  A 501 ( 4.2A)
ANP  A 501 (-4.6A)
 0.84A 5n3hA-6ao5A:
22.1		 5n3hA-6ao5A:
28.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		no annotation 6 VAL A  27
ALA A  40
MET A  95
VAL A  98
LEU A 148
THR A 158
 CJJ  A 301 (-4.6A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.6A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-4.5A)
CJJ  A 301 (-3.1A)
 0.78A 5n3hA-6b2qA:
25.6		 5n3hA-6b2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 6 LEU A  22
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
 EDJ  A 301 (-3.9A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.2A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 (-3.7A)
 0.46A 5n3hA-6bx6A:
23.8		 5n3hA-6bx6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 6 LEU A  22
VAL A  30
ALA A  43
TYR A  95
VAL A  96
LEU A 146
 EDJ  A 301 (-3.9A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 (-3.7A)
EDJ  A 301 ( 4.5A)
 0.68A 5n3hA-6bx6A:
23.8		 5n3hA-6bx6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 LEU A 881
VAL A 889
ALA A 906
VAL A 938
MET A 956
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
ADP  A1201 (-4.2A)
ADP  A1201 (-4.5A)
 0.78A 5n3hA-6c7yA:
24.0		 5n3hA-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 6 VAL A  74
ALA A  87
VAL A 120
MET A 136
TYR A 138
LEU A 189
 None
 0.81A 5n3hA-6c9dA:
30.4		 5n3hA-6c9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE

(Pediculus
humanus) 		no annotation 6 VAL C 173
ALA C 191
VAL C 247
MET C 290
LEU C 341
THR C 356
 None
 0.77A 5n3hA-6eqiC:
21.5		 5n3hA-6eqiC:
25.16