SIMILAR PATTERNS OF AMINO ACIDS FOR 5N1T_W_CUW201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4t PROTEIN (CU/ZN
SUPEROXIDE
DISMUTASE)

(Saccharomyces
cerevisiae) 		PF00080
(Sod_Cu) 		3 HIS A  63
ASP A  83
HIS A  71
 ZN  A 155 (-3.0A)
ZN  A 155 ( 2.3A)
ZN  A 155 ( 3.2A)
 0.76A 5n1tW-1b4tA:
2.4		 5n1tW-1b4tA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo sapiens) 		PF00080
(Sod_Cu) 		3 HIS A 147
ASP A 167
HIS A 155
 ZN  A  28 (-3.1A)
ZN  A  28 (-2.2A)
ZN  A  28 (-3.2A)
 0.73A 5n1tW-1do5A:
2.7		 5n1tW-1do5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqw CU,ZN SUPEROXIDE
DISMUTASE

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		3 HIS A  61
ASP A  81
HIS A  69
 ZN  A 501 ( 3.2A)
ZN  A 501 (-2.4A)
ZN  A 501 (-2.9A)
 0.71A 5n1tW-1eqwA:
2.2		 5n1tW-1eqwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eso CU, ZN SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00080
(Sod_Cu) 		3 HIS A  61
ASP A  81
HIS A  69
 ZN  A 149 ( 3.2A)
ZN  A 149 ( 2.4A)
ZN  A 149 ( 3.0A)
 0.79A 5n1tW-1esoA:
undetectable		 5n1tW-1esoA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eso CU, ZN SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00080
(Sod_Cu) 		3 HIS A  78
ASP A  81
HIS A  69
 ZN  A 149 ( 3.0A)
ZN  A 149 ( 2.4A)
ZN  A 149 ( 3.0A)
 0.91A 5n1tW-1esoA:
undetectable		 5n1tW-1esoA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		3 HIS A 198
ASP A 441
HIS A 443
 None
 0.85A 5n1tW-1f0iA:
undetectable		 5n1tW-1f0iA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzy UBIQUITIN-CONJUGATIN
G ENZYME E2-24 KDA

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		3 HIS A  34
ASP A  31
HIS A  33
 None
 0.91A 5n1tW-1fzyA:
undetectable		 5n1tW-1fzyA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqp DIPEPTIDYL PEPTIDASE
I

(Rattus
norvegicus) 		PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc) 		3 HIS A 352
ASP A 354
HIS A 365
 SO4  A 504 (-3.9A)
None
SO4  A 504 ( 4.9A)
 0.76A 5n1tW-1jqpA:
undetectable		 5n1tW-1jqpA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 435
ASP A 166
HIS A 541
 None
 0.90A 5n1tW-1llaA:
2.3		 5n1tW-1llaA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oal SUPEROXIDE DISMUTASE

(Photobacterium
leiognathi) 		PF00080
(Sod_Cu) 		3 HIS A  70
ASP A  91
HIS A  79
 ZN  A 152 ( 3.1A)
ZN  A 152 (-2.2A)
ZN  A 152 (-3.1A)
 0.66A 5n1tW-1oalA:
1.8		 5n1tW-1oalA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofm CHONDROITINASE B

(Pedobacter
heparinus) 		PF14592
(Chondroitinas_B) 		3 HIS A 164
ASP A 201
HIS A 202
 None
None
MAN  A 601 ( 3.9A)
 0.92A 5n1tW-1ofmA:
undetectable		 5n1tW-1ofmA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1v SUPEROXIDE DISMUTASE
[CU-ZN]

(Homo sapiens) 		PF00080
(Sod_Cu) 		3 HIS A  63
ASP A  83
HIS A  71
 ZN  A 202 (-3.1A)
ZN  A 202 (-2.1A)
ZN  A 202 (-3.1A)
 0.68A 5n1tW-1p1vA:
undetectable		 5n1tW-1p1vA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 HIS A 236
ASP A 234
HIS A 235
 CO  A3000 (-3.2A)
None
CO  A3000 (-3.4A)
 0.93A 5n1tW-1r6xA:
undetectable		 5n1tW-1r6xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srd COPPER,ZINC
SUPEROXIDE DISMUTASE

(Spinacia
oleracea) 		PF00080
(Sod_Cu) 		3 HIS A  63
ASP A  83
HIS A  71
 CU  A 155 ( 3.2A)
ZN  A 156 (-2.7A)
ZN  A 156 (-3.3A)
 0.94A 5n1tW-1srdA:
2.2		 5n1tW-1srdA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxz PROTEIN (CU-ZN
SUPEROXIDE
DISMUTASE)

(Bos taurus) 		PF00080
(Sod_Cu) 		3 HIS A  61
ASP A  81
HIS A  69
 ZN  A 153 ( 3.1A)
ZN  A 153 ( 2.2A)
ZN  A 153 ( 3.2A)
 0.84A 5n1tW-1sxzA:
2.6		 5n1tW-1sxzA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to5 SUPEROXIDE DISMUTASE

(Schistosoma
mansoni) 		PF00080
(Sod_Cu) 		3 HIS A  62
ASP A  82
HIS A  70
 ZN  A 711 ( 3.1A)
ZN  A 711 (-2.2A)
ZN  A 711 (-3.1A)
 0.78A 5n1tW-1to5A:
undetectable		 5n1tW-1to5A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xso COPPER,ZINC
SUPEROXIDE DISMUTASE

(Xenopus laevis) 		PF00080
(Sod_Cu) 		3 HIS A  61
ASP A  81
HIS A  69
 ZN  A 152 (-3.1A)
ZN  A 152 ( 2.2A)
ZN  A 152 ( 3.1A)
 0.85A 5n1tW-1xsoA:
undetectable		 5n1tW-1xsoA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzz INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Mus musculus) 		PF08709
(Ins145_P3_rec) 		3 HIS A 226
ASP A  13
HIS A  10
 None
 0.95A 5n1tW-1xzzA:
undetectable		 5n1tW-1xzzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9n SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		3 HIS A  95
ASP A 116
HIS A 104
 ZN  A 201 ( 3.1A)
ZN  A 201 (-2.1A)
ZN  A 201 (-3.1A)
 0.61A 5n1tW-1z9nA:
2.8		 5n1tW-1z9nA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9p SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		3 HIS A  95
ASP A 116
HIS A 104
 ZN  A 201 ( 3.1A)
ZN  A 201 (-2.2A)
ZN  A 201 (-3.1A)
 0.63A 5n1tW-1z9pA:
2.4		 5n1tW-1z9pA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anp LEUCYL
AMINOPEPTIDASE

(Vibrio
proteolyticus) 		PF04389
(Peptidase_M28) 		3 HIS A  97
ASP A 229
HIS A 151
 ZN  A 502 (-3.3A)
None
ZN  A 502 (-4.2A)
 0.58A 5n1tW-2anpA:
undetectable		 5n1tW-2anpA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anp LEUCYL
AMINOPEPTIDASE

(Vibrio
proteolyticus) 		PF04389
(Peptidase_M28) 		3 HIS A 151
ASP A  99
HIS A  97
 ZN  A 502 (-4.2A)
None
ZN  A 502 (-3.3A)
 0.80A 5n1tW-2anpA:
undetectable		 5n1tW-2anpA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aps PROTEIN (CU,ZN
SUPEROXIDE
DISMUTASE)

(Actinobacillus
pleuropneumoniae) 		PF00080
(Sod_Cu) 		3 HIS A  85
ASP A 106
HIS A  94
 ZN  A 400 (-3.2A)
ZN  A 400 (-2.2A)
ZN  A 400 ( 3.1A)
 0.67A 5n1tW-2apsA:
2.5		 5n1tW-2apsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqt SUPEROXIDE DISMUTASE
[CU-ZN]

(Neisseria
meningitidis) 		no annotation 3 HIS C 104
ASP C 125
HIS C 113
 ZN  C 201 ( 3.1A)
ZN  C 201 (-2.2A)
ZN  C 201 (-3.2A)
 0.65A 5n1tW-2aqtC:
2.5		 5n1tW-2aqtC:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)

(Escherichia
virus phiX174) 		PF02305
(Phage_F) 		3 HIS 1 387
ASP 1 391
HIS 1 388
 None
 0.78A 5n1tW-2bpa1:
undetectable		 5n1tW-2bpa1:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Homo sapiens) 		PF00149
(Metallophos) 		3 HIS X 219
ASP X 220
HIS X 193
 FE2  X1306 (-3.2A)
None
None
 0.90A 5n1tW-2bq8X:
undetectable		 5n1tW-2bq8X:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cir HEXOSE-6-PHOSPHATE
MUTAROTASE

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim) 		3 HIS A 267
ASP A 234
HIS A 269
 None
 0.91A 5n1tW-2cirA:
undetectable		 5n1tW-2cirA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drq XYLANASE Y

(Bacillus
halodurans) 		PF01270
(Glyco_hydro_8) 		3 HIS A 163
ASP A 215
HIS A 167
 None
 0.73A 5n1tW-2drqA:
undetectable		 5n1tW-2drqA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e47 TIME INTERVAL
MEASURING ENZYME
TIME

(Bombyx mori) 		PF00080
(Sod_Cu) 		3 HIS A  67
ASP A  87
HIS A  75
 ZN  A 172 ( 3.1A)
ZN  A 172 (-2.4A)
ZN  A 172 (-3.1A)
 0.80A 5n1tW-2e47A:
2.2		 5n1tW-2e47A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6k METAL-DEPENDENT
HYDROLASE

(Lactobacillus
plantarum) 		PF04909
(Amidohydro_2) 		3 HIS A 205
ASP A 239
HIS A   7
 None
None
MN  A 402 (-3.3A)
 0.92A 5n1tW-2f6kA:
undetectable		 5n1tW-2f6kA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jch PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		3 HIS A 678
ASP A 680
HIS A 682
 None
 0.92A 5n1tW-2jchA:
undetectable		 5n1tW-2jchA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jlp EXTRACELLULAR
SUPEROXIDE DISMUTASE
(CU-ZN)

(Homo sapiens) 		PF00080
(Sod_Cu) 		3 HIS A 113
ASP A 127
HIS A 121
 ZN  A 226 ( 3.1A)
ZN  A 226 (-2.1A)
ZN  A 226 (-3.2A)
 0.79A 5n1tW-2jlpA:
undetectable		 5n1tW-2jlpA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4w SUPEROXIDE DISMUTASE
[CU-ZN]

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		3 HIS A  73
ASP A  93
HIS A  82
 ZN  A 156 ( 3.2A)
ZN  A 156 (-1.6A)
ZN  A 156 (-3.3A)
 0.90A 5n1tW-2k4wA:
1.9		 5n1tW-2k4wA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE

(Zymomonas
mobilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 HIS A 217
ASP A 166
HIS A 215
 None
None
MG  A 402 ( 4.9A)
 0.91A 5n1tW-2ox4A:
undetectable		 5n1tW-2ox4A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0u STILBENECARBOXYLATE
SYNTHASE 2

(Marchantia
polymorpha) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 HIS A 284
ASP A 225
HIS A 223
 None
 0.89A 5n1tW-2p0uA:
undetectable		 5n1tW-2p0uA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2l SUPEROXIDE DISMUTASE

(Potentilla
atrosanguinea) 		PF00080
(Sod_Cu) 		3 HIS A  62
ASP A  82
HIS A  70
 ZN  A1001 (-3.1A)
ZN  A1001 (-2.2A)
ZN  A1001 (-3.3A)
 0.71A 5n1tW-2q2lA:
2.7		 5n1tW-2q2lA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3l UNCHARACTERIZED
PROTEIN

(Shewanella
loihica) 		PF11964
(SpoIIAA-like) 		3 HIS A  68
ASP A  72
HIS A  31
 None
 0.82A 5n1tW-2q3lA:
undetectable		 5n1tW-2q3lA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgq PROTEIN TM_1862

(Thermotoga
maritima) 		PF04055
(Radical_SAM) 		3 HIS A 232
ASP A 193
HIS A 229
 None
 0.92A 5n1tW-2qgqA:
undetectable		 5n1tW-2qgqA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 HIS A 499
ASP A 492
HIS A 491
 None
 0.86A 5n1tW-2wdwA:
undetectable		 5n1tW-2wdwA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wli POTASSIUM CHANNEL

(Magnetospirillum
magnetotacticum) 		PF01007
(IRK) 		3 HIS A 221
ASP A 219
HIS A 220
 None
 0.90A 5n1tW-2wliA:
5.3		 5n1tW-2wliA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 HIS A  84
ASP A 283
HIS A  29
 None
 0.85A 5n1tW-2wskA:
2.2		 5n1tW-2wskA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwo SUPEROXIDE DISMUTASE
[CU-ZN]

(Yersinia
pseudotuberculosis) 		PF00080
(Sod_Cu) 		3 HIS A  79
ASP A 100
HIS A  88
 ZN  A1162 ( 3.2A)
ZN  A1162 (-2.3A)
ZN  A1162 (-3.2A)
 0.74A 5n1tW-2wwoA:
undetectable		 5n1tW-2wwoA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		3 HIS A 484
ASP A 411
HIS A 461
 None
 0.96A 5n1tW-3a1iA:
undetectable		 5n1tW-3a1iA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5m OLIGOGALACTURONATE
LYASE

(Vibrio
parahaemolyticus) 		PF14583
(Pectate_lyase22) 		3 HIS A 355
ASP A 300
HIS A 287
 MN  A 401 (-3.3A)
None
MN  A 401 (-3.1A)
 0.86A 5n1tW-3c5mA:
undetectable		 5n1tW-3c5mA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce1 SUPEROXIDE DISMUTASE
[CU-ZN]

(Naganishia
liquefaciens) 		PF00080
(Sod_Cu) 		3 HIS A  67
ASP A  87
HIS A  75
 ZN  A 202 ( 3.1A)
ZN  A 202 (-2.1A)
ZN  A 202 (-3.1A)
 0.79A 5n1tW-3ce1A:
2.4		 5n1tW-3ce1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		3 HIS A 117
ASP A 110
HIS A 113
 None
 0.64A 5n1tW-3dqzA:
undetectable		 5n1tW-3dqzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE

(Alvinella
pompejana) 		PF00080
(Sod_Cu) 		3 HIS A  61
ASP A  81
HIS A  69
 ZN  A 203 (-3.1A)
ZN  A 203 (-2.2A)
ZN  A 203 (-3.1A)
 0.70A 5n1tW-3f7lA:
undetectable		 5n1tW-3f7lA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 300
ASP A 188
HIS A 241
 None
 0.85A 5n1tW-3g5wA:
undetectable		 5n1tW-3g5wA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtt SUPEROXIDE DISMUTASE
[CU-ZN]

(Mus musculus) 		PF00080
(Sod_Cu) 		3 HIS A  63
ASP A  83
HIS A  71
 ZN  A 155 (-3.2A)
ZN  A 155 (-2.3A)
ZN  A 155 (-3.3A)
 0.75A 5n1tW-3gttA:
undetectable		 5n1tW-3gttA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 484
ASP A 208
HIS A 593
 None
 0.96A 5n1tW-3hhsA:
2.6		 5n1tW-3hhsA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibm CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN

(Halorhodospira
halophila) 		PF07883
(Cupin_2) 		3 HIS A  72
ASP A 132
HIS A  74
 ZN  A 200 (-3.3A)
None
None
 0.83A 5n1tW-3ibmA:
undetectable		 5n1tW-3ibmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzv UNCHARACTERIZED
PROTEIN RRU_A2000

(Rhodospirillum
rubrum) 		PF07883
(Cupin_2) 		3 HIS A  69
ASP A 128
HIS A  71
 MN  A 200 (-3.3A)
None
None
 0.83A 5n1tW-3jzvA:
undetectable		 5n1tW-3jzvA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA

(Methylobacillus
flagellatus) 		PF08886
(GshA) 		3 HIS A 115
ASP A 147
HIS A 149
 GOL  A 445 (-3.4A)
None
None
 0.56A 5n1tW-3k1tA:
undetectable		 5n1tW-3k1tA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgz CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Rhodopseudomonas
palustris) 		PF07883
(Cupin_2) 		3 HIS A  78
ASP A 137
HIS A  80
 MN  A   1 (-3.5A)
None
None
 0.87A 5n1tW-3kgzA:
undetectable		 5n1tW-3kgzA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3km2 SUPEROXIDE DISMUTASE
[CU-ZN],
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00080
(Sod_Cu) 		3 HIS A  63
ASP A  83
HIS A  71
 ZN  A 155 (-3.2A)
ZN  A 155 (-2.3A)
ZN  A 155 (-3.2A)
 0.79A 5n1tW-3km2A:
undetectable		 5n1tW-3km2A:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9y SUPEROXIDE DISMUTASE
[CU-ZN]

(Bombyx mori) 		PF00080
(Sod_Cu) 		3 HIS A  62
ASP A  82
HIS A  70
 ZN  A 155 ( 3.1A)
ZN  A 155 (-2.1A)
ZN  A 155 (-3.2A)
 0.70A 5n1tW-3l9yA:
undetectable		 5n1tW-3l9yA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnd SUPEROXIDE DISMUTASE
[CU-ZN]

(Taenia solium) 		PF00080
(Sod_Cu) 		3 HIS A  60
ASP A  80
HIS A  68
 ZN  A 153 ( 3.1A)
ZN  A 153 (-2.3A)
ZN  A 153 (-3.4A)
 0.82A 5n1tW-3mndA:
2.0		 5n1tW-3mndA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6n APL1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		3 HIS A 437
ASP A 459
HIS A 460
 None
 0.94A 5n1tW-3o6nA:
undetectable		 5n1tW-3o6nA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		3 HIS B 437
ASP B 459
HIS B 460
 None
 0.93A 5n1tW-3ojaB:
undetectable		 5n1tW-3ojaB:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe7 OLIGOGALACTURONATE
LYASE

(Yersinia
enterocolitica) 		PF14583
(Pectate_lyase22) 		3 HIS A 355
ASP A 300
HIS A 287
 MN  A 389 ( 3.3A)
None
MN  A 389 ( 3.3A)
 0.81A 5n1tW-3pe7A:
undetectable		 5n1tW-3pe7A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		3 HIS A 150
ASP A 204
HIS A 376
 None
 0.87A 5n1tW-3t3oA:
undetectable		 5n1tW-3t3oA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		3 HIS A 955
ASP A 531
HIS A 887
 None
 0.95A 5n1tW-3u44A:
undetectable		 5n1tW-3u44A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uan HEPARAN SULFATE
GLUCOSAMINE
3-O-SULFOTRANSFERASE
1

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		3 HIS A 290
ASP A 152
HIS A 311
 None
 0.75A 5n1tW-3uanA:
undetectable		 5n1tW-3uanA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve2 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 HIS A 235
ASP A 234
HIS A 273
 None
 0.88A 5n1tW-3ve2A:
undetectable		 5n1tW-3ve2A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a69 HISTONE DEACETYLASE
3,

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 HIS A 134
ASP A 175
HIS A 135
 ACT  A 501 (-4.0A)
None
ACT  A 501 (-3.7A)
 0.96A 5n1tW-4a69A:
undetectable		 5n1tW-4a69A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		3 HIS A 477
ASP A 437
HIS A 478
 CD  A1984 (-3.9A)
None
CD  A1984 (-4.6A)
 0.90A 5n1tW-4cvuA:
4.9		 5n1tW-4cvuA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3h ARGINASE (ROCF)

(Helicobacter
pylori) 		PF00491
(Arginase) 		3 HIS A 118
ASP A 120
HIS A 133
 MN  A 501 (-3.4A)
MN  A 500 (-2.6A)
None
 0.94A 5n1tW-4g3hA:
undetectable		 5n1tW-4g3hA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha6 PYRIDOXINE 4-OXIDASE

(Mesorhizobium
loti) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 HIS A 143
ASP A 148
HIS A 151
 None
 0.89A 5n1tW-4ha6A:
undetectable		 5n1tW-4ha6A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifr 2-AMINO-3-CARBOXYMUC
ONATE 6-SEMIALDEHYDE
DECARBOXYLASE

(Pseudomonas
fluorescens) 		PF04909
(Amidohydro_2) 		3 HIS A 228
ASP A 268
HIS A   9
 ZN  A 401 ( 4.7A)
None
ZN  A 401 (-3.5A)
 0.96A 5n1tW-4ifrA:
undetectable		 5n1tW-4ifrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN

(Micromonospora
viridifaciens) 		PF13088
(BNR_2) 		3 HIS A 131
ASP A  85
HIS A  69
 None
 0.94A 5n1tW-4j9tA:
undetectable		 5n1tW-4j9tA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc0 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E RIMO

(Thermotoga
maritima) 		PF00919
(UPF0004)
PF04055
(Radical_SAM) 		3 HIS A 232
ASP A 193
HIS A 229
 None
FS5  A 501 ( 4.8A)
FS5  A 501 ( 4.9A)
 0.96A 5n1tW-4jc0A:
undetectable		 5n1tW-4jc0A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzy CRYPTOCHROME-1

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 HIS A 138
ASP A 109
HIS A  13
 None
 0.69A 5n1tW-4jzyA:
undetectable		 5n1tW-4jzyA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kp2 HOMOACONITASE LARGE
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		3 HIS A  32
ASP A  61
HIS A  62
 None
 0.77A 5n1tW-4kp2A:
undetectable		 5n1tW-4kp2A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l05 SUPEROXIDE DISMUTASE
[CU-ZN]

(Brucella
abortus) 		PF00080
(Sod_Cu) 		3 HIS A  73
ASP A  93
HIS A  82
 ZN  A 203 (-3.1A)
ZN  A 203 (-2.2A)
ZN  A 203 (-3.1A)
 0.82A 5n1tW-4l05A:
undetectable		 5n1tW-4l05A:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkp PUTATIVE
EXTRACELLULAR
HEME-BINDING PROTEIN

(Desulfovibrio
piger) 		PF03928
(Haem_degrading) 		3 HIS A  81
ASP A  79
HIS A  80
 None
 0.79A 5n1tW-4nkpA:
undetectable		 5n1tW-4nkpA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oja SUPEROXIDE DISMUTASE
[CU-ZN]

(Hydra vulgaris) 		PF00080
(Sod_Cu) 		3 HIS A  62
ASP A  82
HIS A  70
 ZN  A 202 ( 3.2A)
ZN  A 202 (-2.1A)
ZN  A 202 (-3.1A)
 0.78A 5n1tW-4ojaA:
undetectable		 5n1tW-4ojaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvp SUPEROXIDE DISMUTASE

(Sedum alfredii) 		PF00080
(Sod_Cu) 		3 HIS A  75
ASP A  95
HIS A  83
 ZN  A 201 (-3.2A)
ZN  A 201 (-2.0A)
ZN  A 201 (-3.1A)
 0.83A 5n1tW-4rvpA:
undetectable		 5n1tW-4rvpA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 HIS A  86
ASP A 133
HIS A  87
 ZN  A 802 (-3.6A)
None
ZN  A 802 (-3.2A)
 0.76A 5n1tW-4rvwA:
undetectable		 5n1tW-4rvwA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		3 HIS A 572
ASP A 570
HIS A 502
 None
 0.91A 5n1tW-4ufcA:
undetectable		 5n1tW-4ufcA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyu PROTEIN SCRIBBLE
HOMOLOG

(Homo sapiens) 		PF00595
(PDZ) 		3 HIS A  81
ASP A  33
HIS A  34
 None
 0.92A 5n1tW-4wyuA:
undetectable		 5n1tW-4wyuA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B

(Anopheles
gambiae) 		PF13855
(LRR_8) 		3 HIS A 278
ASP A 300
HIS A 301
 None
 0.94A 5n1tW-4xgoA:
undetectable		 5n1tW-4xgoA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		3 HIS A 153
ASP A 209
HIS A 381
 ZN  A 601 (-3.4A)
None
U5P  A 606 (-3.9A)
 0.96A 5n1tW-4xwtA:
undetectable		 5n1tW-4xwtA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yd8 PROTEIN PTHB1

(Homo sapiens) 		PF14727
(PHTB1_N) 		3 HIS A 328
ASP A 351
HIS A 353
 None
 0.72A 5n1tW-4yd8A:
undetectable		 5n1tW-4yd8A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		3 HIS A 167
ASP A 165
HIS A 156
 ST9  A 403 ( 4.7A)
None
ZN  A 402 (-3.4A)
 0.93A 5n1tW-4ymkA:
undetectable		 5n1tW-4ymkA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5y COENZYME PQQ
SYNTHESIS PROTEIN B

(Pseudomonas
putida) 		PF12706
(Lactamase_B_2) 		3 HIS A 306
ASP A 215
HIS A 307
 None
 0.90A 5n1tW-4z5yA:
undetectable		 5n1tW-4z5yA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 HIS A 929
ASP A 775
HIS A 777
 None
 0.87A 5n1tW-4zdnA:
undetectable		 5n1tW-4zdnA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 3 HIS A 171
ASP A 169
HIS A 160
 ST9  A 403 (-4.3A)
None
ZN  A 402 (-3.2A)
 0.92A 5n1tW-4zyoA:
undetectable		 5n1tW-4zyoA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aho 5' EXONUCLEASE
APOLLO

(Homo sapiens) 		PF07522
(DRMBL) 		3 HIS A  99
ASP A 145
HIS A 276
 ZN  A1321 ( 3.4A)
None
TLA  A1319 ( 3.9A)
 0.90A 5n1tW-5ahoA:
undetectable		 5n1tW-5ahoA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		3 HIS A 138
ASP A 168
HIS A 169
 None
 0.91A 5n1tW-5gkqA:
undetectable		 5n1tW-5gkqA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icu COPC

(Methylosinus
trichosporium) 		PF04234
(CopC) 		3 HIS A  23
ASP A 105
HIS A 107
 CU  A 201 ( 3.1A)
CU  A 201 (-2.5A)
CU  A 201 (-3.0A)
 0.30A 5n1tW-5icuA:
11.7		 5n1tW-5icuA:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in2 EXTRACELLULAR
SUPEROXIDE DISMUTASE
[CU-ZN]

(Onchocerca
volvulus) 		PF00080
(Sod_Cu) 		3 HIS A  63
ASP A  83
HIS A  71
 ZN  A 202 (-3.1A)
ZN  A 202 (-2.1A)
ZN  A 202 (-3.1A)
 0.72A 5n1tW-5in2A:
undetectable		 5n1tW-5in2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		3 HIS A 108
ASP A 131
HIS A 132
 None
 0.90A 5n1tW-5lfnA:
undetectable		 5n1tW-5lfnA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m49 AMINOTRANSFERASE
CLASS-III

(Rhizobium
freirei) 		PF00202
(Aminotran_3) 		3 HIS A 108
ASP A 112
HIS A 297
 None
 0.96A 5n1tW-5m49A:
undetectable		 5n1tW-5m49A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqo NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bacteroides
thetaiotaomicron) 		PF07944
(Glyco_hydro_127) 		3 HIS A 296
ASP A 280
HIS A 364
 None
 0.78A 5n1tW-5mqoA:
undetectable		 5n1tW-5mqoA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx0 FIBROMODULIN

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 HIS A 164
ASP A 184
HIS A 185
 None
 0.95A 5n1tW-5mx0A:
undetectable		 5n1tW-5mx0A:
18.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n1t COPC

(Thioalkalivibrio
paradoxus) 		no annotation 3 HIS M   1
ASP M 110
HIS M 112
 None
 0.40A 5n1tW-5n1tM:
23.7		 5n1tW-5n1tM:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1r GNA2132

(Neisseria
meningitidis) 		no annotation 3 HIS A 327
ASP A 359
HIS A 362
 None
 0.75A 5n1tW-5o1rA:
undetectable		 5n1tW-5o1rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oes GLUTATHIONE
SYNTHETASE

(Solanum
tuberosum) 		no annotation 3 HIS A  16
ASP A  14
HIS A 417
 None
 0.78A 5n1tW-5oesA:
undetectable		 5n1tW-5oesA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		3 HIS A 469
ASP A  69
HIS A  74
 None
 0.86A 5n1tW-5xfaA:
undetectable		 5n1tW-5xfaA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fi2 VEXL

(Achromobacter
denitrificans) 		no annotation 3 HIS A 136
ASP A 162
HIS A 163
 None
 0.96A 5n1tW-6fi2A:
undetectable		 5n1tW-6fi2A:
undetectable