SIMILAR PATTERNS OF AMINO ACIDS FOR 5N0X_B_SAMB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg4 ENDO-1,4-BETA-XYLANA
SE

(Penicillium
simplicissimum) 		PF00331
(Glyco_hydro_10) 		5 ILE A 205
GLY A 206
PHE A 134
ALA A 229
VAL A 185
 None
None
None
NA  A 619 ( 3.8A)
None
 1.18A 5n0xB-1bg4A:
undetectable		 5n0xB-1bg4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ILE A 262
GLY A 264
PHE A 460
TYR A 161
ALA A 198
 None
 1.16A 5n0xB-1br2A:
0.5		 5n0xB-1br2A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egz ENDOGLUCANASE Z

(Dickeya
chrysanthemi) 		PF00150
(Cellulase) 		5 GLY A  23
VAL A 280
GLN A 285
ALA A 291
MET A  91
 None
 1.18A 5n0xB-1egzA:
undetectable		 5n0xB-1egzA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 ILE A  88
GLY A  84
HIS A  83
TYR A 195
ALA A 102
 None
 1.14A 5n0xB-1ex9A:
2.1		 5n0xB-1ex9A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A 253
GLY A 255
PHE A 449
TYR A 163
ALA A 200
 None
 1.06A 5n0xB-1g8xA:
0.0		 5n0xB-1g8xA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		5 ILE A 402
GLY A 403
HIS A 405
VAL A 466
ALA A 445
 None
None
None
None
TTP  A1589 (-4.8A)
 1.02A 5n0xB-1h79A:
2.4		 5n0xB-1h79A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		5 ILE A 241
GLY A 290
PHE A 294
MET A 233
VAL A 211
 None
 1.28A 5n0xB-1hjuA:
undetectable		 5n0xB-1hjuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		5 ILE S 262
GLY S 264
PHE S 460
TYR S 161
ALA S 198
 None
 1.08A 5n0xB-1i84S:
1.4		 5n0xB-1i84S:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ILE A 264
GLY A 266
PHE A 460
TYR A 174
ALA A 211
 None
 1.03A 5n0xB-1jx2A:
0.0		 5n0xB-1jx2A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1d D-HYDANTOINASE

(Geobacillus
stearothermophilus) 		PF01979
(Amidohydro_1) 		5 ILE A 118
GLY A 450
PHE A 443
ALA A  81
VAL A 430
 None
 1.24A 5n0xB-1k1dA:
undetectable		 5n0xB-1k1dA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		5 GLY A 118
HIS A 117
PHE A  58
GLN A  59
ALA A 127
 None
 1.16A 5n0xB-1kl7A:
1.6		 5n0xB-1kl7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		5 ILE A 309
GLY A 147
PHE A 202
ALA A 216
VAL A 297
 None
 1.22A 5n0xB-1l8wA:
undetectable		 5n0xB-1l8wA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		5 ILE A 424
GLY A 423
VAL A 293
PHE A 220
ALA A 106
 None
None
None
None
HEA  A 601 (-3.3A)
 1.24A 5n0xB-1qleA:
undetectable		 5n0xB-1qleA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txk GLUCANS BIOSYNTHESIS
PROTEIN G

(Escherichia
coli) 		PF04349
(MdoG) 		5 ILE A 193
PHE A 130
VAL A  93
PHE A  82
VAL A 135
 None
 1.28A 5n0xB-1txkA:
undetectable		 5n0xB-1txkA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		5 ILE A 110
GLY A  93
PHE A 309
TYR A 160
ALA A 161
 None
SEP  A  92 ( 2.4A)
None
None
None
 1.12A 5n0xB-1zefA:
2.3		 5n0xB-1zefA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		5 ILE A 182
HIS A 143
PHE A  93
VAL A  95
ALA A 208
 None
None
EDO  A 404 ( 4.6A)
None
None
 1.09A 5n0xB-2ashA:
undetectable		 5n0xB-2ashA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Homo sapiens) 		PF00698
(Acyl_transf_1) 		5 ILE A  88
GLY A  33
PHE A 233
ALA A  87
VAL A 139
 None
AE4  A1346 (-3.7A)
None
None
None
 1.15A 5n0xB-2c2nA:
undetectable		 5n0xB-2c2nA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddt SPHINGOMYELIN
PHOSPHODIESTERASE

(Bacillus cereus) 		PF03372
(Exo_endo_phos) 		5 ILE A 255
GLY A 193
VAL A 103
ALA A 301
VAL A  48
 None
 1.18A 5n0xB-2ddtA:
undetectable		 5n0xB-2ddtA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddt SPHINGOMYELIN
PHOSPHODIESTERASE

(Bacillus cereus) 		PF03372
(Exo_endo_phos) 		5 ILE A 255
GLY A 194
VAL A 103
ALA A 301
VAL A  48
 None
 1.24A 5n0xB-2ddtA:
undetectable		 5n0xB-2ddtA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		5 GLY A  28
VAL A  62
ALA A 333
MET A 329
VAL A 310
 None
 1.02A 5n0xB-2e28A:
undetectable		 5n0xB-2e28A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 ILE A  76
GLY A  92
TYR A 398
ALA A  75
MET A  72
 None
 1.19A 5n0xB-2e4uA:
2.4		 5n0xB-2e4uA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY

(Deinococcus
radiodurans) 		PF00210
(Ferritin) 		5 ILE A 200
PHE A 101
ALA A 199
MET A 201
VAL A 154
 None
 1.28A 5n0xB-2f7nA:
undetectable		 5n0xB-2f7nA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i99 MU-CRYSTALLIN
HOMOLOG

(Homo sapiens) 		PF02423
(OCD_Mu_crystall) 		5 GLY A  57
HIS A  55
VAL A  88
GLN A  93
VAL A  77
 None
 1.25A 5n0xB-2i99A:
2.3		 5n0xB-2i99A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran) 		5 ILE A  49
PHE A  31
GLN A 180
ALA A  50
VAL A 154
 None
 1.29A 5n0xB-2it1A:
undetectable		 5n0xB-2it1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lss COLD SHOCK-LIKE
PROTEIN

(Rickettsia
rickettsii) 		PF00313
(CSD) 		5 ILE A   5
GLY A   7
PHE A  20
ALA A   2
VAL A  65
 None
 1.30A 5n0xB-2lssA:
undetectable		 5n0xB-2lssA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq9 ENDONUCLEASE 4

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		5 ILE A 126
GLY A 111
HIS A 109
PHE A  91
ALA A 127
 None
None
ZN  A 401 (-3.2A)
None
None
 1.02A 5n0xB-2nq9A:
undetectable		 5n0xB-2nq9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 ILE A  10
GLY A  90
VAL A 184
ALA A  29
VAL A 242
 None
 1.04A 5n0xB-2ntjA:
2.1		 5n0xB-2ntjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5r GLUTAMYL-TRNA
SYNTHETASE 1

(Thermotoga
maritima) 		PF00749
(tRNA-synt_1c) 		5 ILE A 243
GLY A  17
HIS A  15
VAL A 260
ALA A 310
 None
 1.26A 5n0xB-2o5rA:
undetectable		 5n0xB-2o5rA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6h HYPOTHETICAL PROTEIN

(Aeropyrum
pernix) 		PF01894
(UPF0047) 		5 ILE A  93
GLY A  89
HIS A  87
ALA A  49
VAL A  16
 None
 1.20A 5n0xB-2p6hA:
undetectable		 5n0xB-2p6hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prr ALKYLHYDROPEROXIDASE
AHPD CORE:
UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Cupriavidus
pinatubonensis) 		PF02627
(CMD) 		5 ILE A  96
PHE A 168
TYR A  88
ALA A  92
VAL A  78
 None
None
PEG  A 199 (-4.7A)
None
None
 1.18A 5n0xB-2prrA:
undetectable		 5n0xB-2prrA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN

(Desulfotalea
psychrophila) 		PF02634
(FdhD-NarQ) 		5 GLY A 172
HIS A 174
VAL A 177
PHE A  57
VAL A  52
 None
 1.27A 5n0xB-2pw9A:
undetectable		 5n0xB-2pw9A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q09 IMIDAZOLONEPROPIONAS
E

(unidentified) 		PF01979
(Amidohydro_1) 		5 GLY A 241
HIS A 242
PHE A 220
GLN A 224
ALA A 232
 None
FE  A 500 ( 3.5A)
None
None
None
 1.13A 5n0xB-2q09A:
undetectable		 5n0xB-2q09A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		5 ILE A 140
GLY A 139
PHE A 134
PHE A 236
ALA A 210
 None
 1.22A 5n0xB-2uw2A:
undetectable		 5n0xB-2uw2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbk TAILSPIKE-PROTEIN

(Shigella virus
Sf6) 		PF12708
(Pectate_lyase_3) 		5 ILE A 454
GLY A 434
VAL A 407
PHE A 417
VAL A 479
 None
 1.19A 5n0xB-2vbkA:
undetectable		 5n0xB-2vbkA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		5 ILE A 158
GLY A  88
TYR A 149
ALA A 151
VAL A  95
 None
 1.28A 5n0xB-2w5fA:
undetectable		 5n0xB-2w5fA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 ILE A 221
GLY A 190
HIS A 143
VAL A 195
TYR A 287
 None
None
B12  A 800 (-4.2A)
None
None
 1.27A 5n0xB-2xijA:
2.7		 5n0xB-2xijA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE

(Thermotoga
maritima) 		PF04029
(2-ph_phosp) 		5 GLY A 162
HIS A 166
VAL A 153
PHE A 146
VAL A 133
 None
 1.22A 5n0xB-2yyvA:
3.0		 5n0xB-2yyvA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1k (NEO)PULLULANASE

(Thermus
thermophilus) 		PF00128
(Alpha-amylase) 		5 ILE A 192
GLY A 198
VAL A 230
PHE A 216
ALA A 223
 None
 1.22A 5n0xB-2z1kA:
undetectable		 5n0xB-2z1kA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		5 GLY B 287
VAL B 341
TYR B 328
ALA B 296
VAL B 283
 None
 1.00A 5n0xB-3aeqB:
1.5		 5n0xB-3aeqB:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2

(Mus musculus) 		PF04916
(Phospholip_B) 		5 ILE A 319
HIS A 266
TYR A 388
ALA A 546
MET A 549
 None
 1.29A 5n0xB-3fgwA:
undetectable		 5n0xB-3fgwA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvp ADENOSYLHOMOCYSTEINA
SE 3

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLY A 339
HIS A 341
GLN A 366
ALA A 356
VAL A 359
 None
 1.24A 5n0xB-3gvpA:
undetectable		 5n0xB-3gvpA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		5 ILE A  65
GLY A  10
PHE A 198
ALA A  64
VAL A 112
 None
None
ACT  A 500 (-4.8A)
None
None
 1.04A 5n0xB-3im8A:
undetectable		 5n0xB-3im8A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		5 ILE A 262
GLY A 264
PHE A 460
TYR A 161
ALA A 198
 None
 1.04A 5n0xB-3j04A:
undetectable		 5n0xB-3j04A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkv PUTATIVE
AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 ILE A 239
GLY A 253
HIS A 252
VAL A 301
ALA A 240
 None
None
ZN  A 426 (-3.6A)
None
None
 1.25A 5n0xB-3mkvA:
undetectable		 5n0xB-3mkvA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Shewanella
loihica) 		PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 175
GLY A 174
HIS A 172
GLN A 147
ALA A 154
 None
 1.29A 5n0xB-3ntdA:
undetectable		 5n0xB-3ntdA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3org CMCLC

(Cyanidioschyzon
merolae) 		PF00654
(Voltage_CLC) 		5 ILE A 698
TYR A 688
HIS A 552
PHE A 575
VAL A 577
 None
 1.17A 5n0xB-3orgA:
undetectable		 5n0xB-3orgA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzj PROBABLE
ACETYLTRANSFERASES

(Chromobacterium
violaceum) 		PF13302
(Acetyltransf_3) 		5 TYR A  91
GLY A 106
HIS A 121
VAL A  83
ALA A 145
 None
None
EDO  A 207 (-4.0A)
NA  A 301 (-4.3A)
None
 1.03A 5n0xB-3pzjA:
undetectable		 5n0xB-3pzjA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s30 HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus) 		PF13201
(PCMD) 		5 GLY A 357
PHE A 274
TYR A 299
ALA A 295
VAL A 350
 None
 1.27A 5n0xB-3s30A:
undetectable		 5n0xB-3s30A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfw DIHYDROPYRIMIDINASE

(Brevibacillus
agri) 		PF01979
(Amidohydro_1) 		5 ILE A 118
GLY A 450
PHE A 443
ALA A  81
VAL A 430
 None
 1.20A 5n0xB-3sfwA:
undetectable		 5n0xB-3sfwA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 ILE A  51
GLY A  67
TYR A 373
ALA A  50
MET A  47
 None
 1.22A 5n0xB-3sm9A:
3.0		 5n0xB-3sm9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		5 ILE A 140
GLY A 139
PHE A 134
PHE A 236
ALA A 210
 None
 1.24A 5n0xB-3vpoA:
undetectable		 5n0xB-3vpoA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpd ALCOHOL
DEHYDROGENASE

(Thermus sp.
ATN1) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 185
GLY A 181
VAL A 266
ALA A 214
VAL A 172
 None
None
NAD  A1407 (-4.0A)
None
None
 1.22A 5n0xB-4cpdA:
2.6		 5n0xB-4cpdA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ff5 GLYCOSYL HYDROLASE
25

(Streptococcus
pneumoniae) 		PF01183
(Glyco_hydro_25) 		5 ILE A 159
GLY A 160
VAL A 132
TYR A 117
ALA A 156
 None
 1.27A 5n0xB-4ff5A:
undetectable		 5n0xB-4ff5A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hac MEVALONATE KINASE

(Methanosarcina
mazei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A 100
GLY A 123
HIS A 124
GLN A 117
ALA A   6
 None
 1.06A 5n0xB-4hacA:
undetectable		 5n0xB-4hacA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbs PUTATIVE HYDROLASE

(Bacteroides
ovatus) 		PF16396
(DUF5005) 		5 ILE A 306
GLY A 348
HIS A 345
TYR A 242
ALA A 265
 None
 1.27A 5n0xB-4hbsA:
undetectable		 5n0xB-4hbsA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		5 ILE A  27
GLY A  24
GLN A 166
ALA A 231
MET A 227
 None
 1.21A 5n0xB-4imrA:
undetectable		 5n0xB-4imrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		5 ILE A  10
GLY A  87
VAL A 179
ALA A  27
VAL A 230
 None
 1.03A 5n0xB-4ituA:
undetectable		 5n0xB-4ituA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 ILE B 163
TYR B 164
PHE B 469
GLN B  34
ALA B 463
 None
 1.23A 5n0xB-4l37B:
1.6		 5n0xB-4l37B:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 5 ILE A  49
GLY A 492
HIS A 494
VAL A 320
ALA A  44
 None
 1.11A 5n0xB-4lc9A:
2.1		 5n0xB-4lc9A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.03A 5n0xB-4o7dA:
undetectable		 5n0xB-4o7dA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A 256
GLY A 258
PHE A 454
TYR A 162
ALA A 199
 None
 1.15A 5n0xB-4pd3A:
2.8		 5n0xB-4pd3A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE

(Leishmania
major) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ILE A 307
GLY A 295
HIS A 218
PHE A 234
ALA A 415
 None
 1.28A 5n0xB-4qg5A:
undetectable		 5n0xB-4qg5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiq D-XYLOSE-PROTON
SYMPORTER

(Escherichia
coli) 		PF00083
(Sugar_tr) 		5 GLY A  58
PHE A  42
VAL A  43
PHE A 129
ALA A  64
 None
 1.28A 5n0xB-4qiqA:
undetectable		 5n0xB-4qiqA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 104
GLY A 188
GLN A  83
ALA A 143
VAL A  78
 None
 1.26A 5n0xB-4r8eA:
undetectable		 5n0xB-4r8eA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 104
GLY A 189
GLN A  83
ALA A 143
VAL A  78
 None
 1.18A 5n0xB-4r8eA:
undetectable		 5n0xB-4r8eA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rph UDP-GALACTOPYRANOSE
MUTASE

(Mycobacterium
tuberculosis) 		no annotation 5 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.92A 5n0xB-4rphB:
undetectable		 5n0xB-4rphB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 177
GLY A 173
VAL A 259
ALA A 206
VAL A 164
 None
 1.15A 5n0xB-4uekA:
2.9		 5n0xB-4uekA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 ILE A 358
GLY A 391
VAL A 206
ALA A 357
MET A 359
 None
 1.24A 5n0xB-4umvA:
undetectable		 5n0xB-4umvA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		6 ILE A 358
GLY A 391
VAL A 397
PHE A 350
ALA A 357
MET A 359
 None
 1.06A 5n0xB-4umvA:
undetectable		 5n0xB-4umvA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unf ENDONUCLEASE III-1

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		5 ILE A 179
GLY A 177
PHE A 246
ALA A 187
VAL A 169
 None
 1.07A 5n0xB-4unfA:
undetectable		 5n0xB-4unfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xin LPQH ORTHOLOGUE

(Mycobacterium
avium) 		PF05481
(Myco_19_kDa) 		5 ILE A 100
VAL A  33
ALA A  89
MET A  91
VAL A  57
 None
 1.05A 5n0xB-4xinA:
undetectable		 5n0xB-4xinA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620) 		no annotation 5 ILE A 215
TYR A 204
GLY A 214
HIS A 212
GLN A 281
 None
None
None
RAM  A1001 (-3.7A)
None
 1.16A 5n0xB-4xn3A:
undetectable		 5n0xB-4xn3A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE

(Geobacillus
stearothermophilus) 		PF00232
(Glyco_hydro_1) 		5 ILE A 175
TYR A 179
GLY A 178
HIS A 184
ALA A 201
 None
 1.21A 5n0xB-4zfmA:
undetectable		 5n0xB-4zfmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv4 ELONGATION FACTOR TU

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 ILE A  18
GLY A  19
HIS A  23
ALA A 102
VAL A  80
 None
 1.21A 5n0xB-4zv4A:
2.1		 5n0xB-4zv4A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv4 ELONGATION FACTOR TU

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 ILE A  18
TYR A  88
HIS A  23
ALA A 102
VAL A  80
 None
 1.14A 5n0xB-4zv4A:
2.1		 5n0xB-4zv4A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN

(Stackebrandtia
nassauensis) 		PF03734
(YkuD) 		5 ILE A 130
GLY A 128
PHE A 147
GLN A 148
ALA A 132
 None
 1.29A 5n0xB-5bmqA:
undetectable		 5n0xB-5bmqA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 ILE A 493
GLY A 519
HIS A 521
PHE A 473
ALA A 485
 None
 1.03A 5n0xB-5d3oA:
undetectable		 5n0xB-5d3oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejk GAG-PRO-POL
POLYPROTEIN

(Rous sarcoma
virus) 		PF00552
(IN_DBD_C)
PF00665
(rve)
PF02022
(Integrase_Zn) 		5 ILE A  88
HIS A 212
VAL A 111
ALA A 159
MET A 163
 None
 1.29A 5n0xB-5ejkA:
undetectable		 5n0xB-5ejkA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct) 		PF00291
(PALP) 		5 GLY B 132
VAL B 143
TYR B 183
ALA B 170
VAL B 128
 None
 1.23A 5n0xB-5ey5B:
undetectable		 5n0xB-5ey5B:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA

(Escherichia
coli) 		PF09481
(CRISPR_Cse1) 		5 ILE A 146
GLY A 142
PHE A 100
GLN A 102
ALA A  46
 None
 1.26A 5n0xB-5h9fA:
undetectable		 5n0xB-5h9fA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		5 GLY A 420
PHE A 451
GLN A 399
TYR A 393
ALA A 414
 None
 1.23A 5n0xB-5hvmA:
undetectable		 5n0xB-5hvmA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A 276
GLY A 278
PHE A 473
TYR A 182
ALA A 219
 None
 1.08A 5n0xB-5i4eA:
1.8		 5n0xB-5i4eA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		5 ILE A 349
GLY A 348
HIS A 370
PHE A 411
VAL A 361
 None
 1.25A 5n0xB-5j44A:
undetectable		 5n0xB-5j44A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j68 ASTROTACTIN-2

(Homo sapiens) 		PF01823
(MACPF) 		5 ILE A 846
GLY A 850
HIS A 848
VAL A 742
ALA A 978
 None
 1.26A 5n0xB-5j68A:
undetectable		 5n0xB-5j68A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j69 ASTROTACTIN-2

(Homo sapiens) 		PF01823
(MACPF) 		5 ILE A 846
GLY A 850
HIS A 848
VAL A 742
ALA A 978
 None
 1.15A 5n0xB-5j69A:
undetectable		 5n0xB-5j69A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 ILE A  78
GLY A  94
TYR A 425
ALA A  77
MET A  74
 None
 1.26A 5n0xB-5k5tA:
2.5		 5n0xB-5k5tA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 ILE A 395
GLY A 249
VAL A 329
TYR A 391
MET A 381
 None
FAD  A 901 (-3.4A)
None
None
None
 1.24A 5n0xB-5l46A:
undetectable		 5n0xB-5l46A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsr CCMP

(Synechococcus
elongatus) 		no annotation 5 ILE A 164
GLY A 181
PHE A 179
GLN A 168
ALA A 158
 None
 1.15A 5n0xB-5lsrA:
undetectable		 5n0xB-5lsrA:
19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n0o PEPTIDE
N-METHYLTRANSFERASE

(Omphalotus
olearius) 		no annotation 5 ILE A  19
GLY A  18
TYR A 211
ALA A 213
VAL A 243
 SAM  A 501 (-4.5A)
None
SAM  A 501 (-4.7A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.0A)
 0.91A 5n0xB-5n0oA:
45.7		 5n0xB-5n0oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n0o PEPTIDE
N-METHYLTRANSFERASE

(Omphalotus
olearius) 		no annotation 11 ILE A  19
TYR A  98
GLY A  99
HIS A 100
PHE A 104
VAL A 105
PHE A 171
GLN A 172
TYR A 211
ALA A 213
VAL A 243
 SAM  A 501 (-4.5A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.5A)
None
None
None
SAM  A 501 (-4.3A)
HSE  A 504 ( 3.3A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.0A)
 0.10A 5n0xB-5n0oA:
45.7		 5n0xB-5n0oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n0o PEPTIDE
N-METHYLTRANSFERASE

(Omphalotus
olearius) 		no annotation 8 ILE A  19
TYR A  98
GLY A  99
HIS A 100
VAL A 105
GLN A 172
ALA A 213
MET A 215
 SAM  A 501 (-4.5A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.5A)
None
None
HSE  A 504 ( 3.3A)
SAM  A 501 (-3.6A)
None
 0.61A 5n0xB-5n0oA:
45.7		 5n0xB-5n0oA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 5 ILE A1087
PHE A1066
GLN A1103
ALA A1158
VAL A1175
 None
 1.27A 5n0xB-5ngyA:
undetectable		 5n0xB-5ngyA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 GLY B 474
HIS B 473
VAL B 468
ALA B 509
VAL B 489
 None
 0.96A 5n0xB-5up2B:
undetectable		 5n0xB-5up2B:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqd DUMPY: SHORTER THAN
WILD-TYPE

(Caenorhabditis
elegans) 		no annotation 5 ILE A1506
GLY A1505
PHE A1409
TYR A1335
ALA A1339
 None
 1.12A 5n0xB-5uqdA:
undetectable		 5n0xB-5uqdA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase)
PF12796
(Ank_2) 		5 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.05A 5n0xB-5uqeA:
undetectable		 5n0xB-5uqeA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w76 ANCESTRAL ELOGATION
FACTOR N153

(synthetic
construct) 		no annotation 5 ILE A  18
TYR A  88
HIS A  23
ALA A 102
VAL A  80
 None
 1.21A 5n0xB-5w76A:
undetectable		 5n0xB-5w76A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wml -

(-) 		no annotation 5 ILE A 274
GLY A 303
VAL A 164
GLN A 170
TYR A 196
 PMP  A 501 ( 4.7A)
None
None
None
None
 1.17A 5n0xB-5wmlA:
2.9		 5n0xB-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER

(Klebsiella
pneumoniae) 		PF03390
(2HCT) 		5 ILE A  86
GLY A  66
PHE A  75
ALA A  90
MET A 341
 None
 1.18A 5n0xB-5x9rA:
undetectable		 5n0xB-5x9rA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8

(Homo sapiens) 		no annotation 5 ILE A  83
GLY A  99
TYR A 410
ALA A  82
MET A  79
 None
 1.28A 5n0xB-6bszA:
undetectable		 5n0xB-6bszA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6con COA-TRANSFERASE
SUBUNIT ALPHA
COA-TRANSFERASE
SUBUNIT BETA

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		no annotation
no annotation 		6 ILE A 183
TYR A 180
GLY A 182
VAL A 215
GLN A 218
ALA B  53
 None
 1.34A 5n0xB-6conA:
undetectable		 5n0xB-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bml STREPTOKINASE

(Streptococcus
dysgalactiae) 		PF02821
(Staphylokinase) 		3 SER C 105
ALA C 104
THR C  25
 None
 0.63A 5n0xB-1bmlC:
0.0		 5n0xB-1bmlC:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byr PROTEIN
(ENDONUCLEASE)

(Salmonella
enterica) 		PF13091
(PLDc_2) 		3 SER A  21
ALA A  22
THR A 104
 None
 0.72A 5n0xB-1byrA:
undetectable		 5n0xB-1byrA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eq2 ADP-L-GLYCERO-D-MANN
OHEPTOSE 6-EPIMERASE

(Escherichia
coli) 		PF01370
(Epimerase) 		3 SER A 116
ALA A 117
THR A 276
 NAP  A2400 (-3.1A)
None
None
 0.51A 5n0xB-1eq2A:
0.0		 5n0xB-1eq2A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhk IG GAMMA-1-CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  25
ALA H  24
THR H  94
 None
 0.74A 5n0xB-1jhkH:
0.0		 5n0xB-1jhkH:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		3 SER A 485
ALA A 486
THR A 392
 None
 0.75A 5n0xB-1kv9A:
0.0		 5n0xB-1kv9A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxq ANTIBODY VHH
FRAGMENT CABAMD9

(Camelus
dromedarius) 		PF07686
(V-set) 		3 SER E  25
ALA E  24
THR E  95
 None
 0.73A 5n0xB-1kxqE:
undetectable		 5n0xB-1kxqE:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l4d STREPTOKINASE

(Streptococcus
dysgalactiae) 		PF02821
(Staphylokinase) 		3 SER B 105
ALA B 104
THR B  25
 None
 0.54A 5n0xB-1l4dB:
undetectable		 5n0xB-1l4dB:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l4z STREPTOKINASE

(Streptococcus
dysgalactiae) 		PF02821
(Staphylokinase) 		3 SER B 105
ALA B 104
THR B  25
 None
 0.67A 5n0xB-1l4zB:
undetectable		 5n0xB-1l4zB:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		3 SER A 200
ALA A 201
THR A 246
 PLP  A 400 (-2.7A)
None
None
 0.63A 5n0xB-1n8pA:
1.8		 5n0xB-1n8pA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd H57 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER E  90
ALA E  33
THR E  66
 None
 0.71A 5n0xB-1nfdE:
undetectable		 5n0xB-1nfdE:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npc NEUTRAL PROTEASE

(Bacillus cereus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		3 SER A 135
ALA A  74
THR A  42
 None
 0.75A 5n0xB-1npcA:
undetectable		 5n0xB-1npcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Thermus
thermophilus) 		PF01467
(CTP_transf_like) 		3 SER A  47
ALA A  48
THR A  69
 None
 0.73A 5n0xB-1od6A:
undetectable		 5n0xB-1od6A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 SER A 251
ALA A 252
THR A   8
 None
 0.75A 5n0xB-1tqyA:
undetectable		 5n0xB-1tqyA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		3 SER A 277
ALA A 274
THR A 292
 None
 0.71A 5n0xB-1vkoA:
1.9		 5n0xB-1vkoA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		3 SER C  84
ALA C  85
THR C 176
 None
 0.36A 5n0xB-1w36C:
0.9		 5n0xB-1w36C:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlg FLAGELLAR HOOK
PROTEIN FLGE

(Salmonella
enterica) 		PF07559
(FlaE) 		3 SER A 152
ALA A 151
THR A 148
 None
 0.73A 5n0xB-1wlgA:
undetectable		 5n0xB-1wlgA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp4 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptococcus
pneumoniae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 SER A  97
ALA A  96
THR A 166
 SO4  A 464 ( 3.9A)
None
None
 0.47A 5n0xB-1xp4A:
undetectable		 5n0xB-1xp4A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2i MALATE DEHYDROGENASE

(Agrobacterium
tumefaciens) 		PF02615
(Ldh_2) 		3 SER A 248
ALA A 276
THR A  99
 None
 0.71A 5n0xB-1z2iA:
undetectable		 5n0xB-1z2iA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2clb DPS-LIKE PROTEIN

(Sulfolobus
solfataricus) 		PF00210
(Ferritin) 		3 SER A  99
ALA A 100
THR A 130
 None
 0.71A 5n0xB-2clbA:
undetectable		 5n0xB-2clbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6u ORNITHINE
CARBAMOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 SER A 283
ALA A 284
THR A 138
 None
 0.73A 5n0xB-2i6uA:
2.0		 5n0xB-2i6uA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6k FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		3 SER A 210
ALA A 211
THR A  52
 None
 0.74A 5n0xB-2m6kA:
undetectable		 5n0xB-2m6kA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5i BH3822 PROTEIN

(Bacillus
halodurans) 		PF03099
(BPL_LplA_LipB) 		3 SER A  32
ALA A  29
THR A  60
 None
 0.70A 5n0xB-2p5iA:
undetectable		 5n0xB-2p5iA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfv EXOCYST COMPLEX
COMPONENT EXO70

(Saccharomyces
cerevisiae) 		PF03081
(Exo70) 		3 SER A  73
ALA A  72
THR A  67
 None
 0.57A 5n0xB-2pfvA:
undetectable		 5n0xB-2pfvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qny 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Mycobacterium
tuberculosis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 SER A  50
ALA A  51
THR A  80
 None
 0.71A 5n0xB-2qnyA:
undetectable		 5n0xB-2qnyA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		3 SER A 433
ALA A 430
THR A 362
 None
 0.71A 5n0xB-2qzpA:
2.2		 5n0xB-2qzpA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rui LPXTG-SITE
TRANSPEPTIDASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF04203
(Sortase) 		3 SER A 140
ALA A 139
THR A 186
 None
 0.75A 5n0xB-2ruiA:
undetectable		 5n0xB-2ruiA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		3 SER A 303
ALA A 304
THR A 356
 None
 0.57A 5n0xB-2v5dA:
undetectable		 5n0xB-2v5dA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x86 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E

(Escherichia
coli) 		PF01370
(Epimerase) 		3 SER A 116
ALA A 117
THR A 276
 BMA  A 402 ( 3.2A)
None
None
 0.31A 5n0xB-2x86A:
undetectable		 5n0xB-2x86A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN

(Prochlorococcus
marinus) 		PF00142
(Fer4_NifH) 		3 SER A  54
ALA A  51
THR A 247
 None
 0.72A 5n0xB-2ynmA:
undetectable		 5n0xB-2ynmA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2

(Methanocaldococcus
jannaschii) 		PF00155
(Aminotran_1_2) 		3 SER A 203
ALA A 204
THR A 214
 None
 0.57A 5n0xB-2z61A:
undetectable		 5n0xB-2z61A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a69 FLAGELLAR HOOK
PROTEIN FLGE

(Salmonella
enterica) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07559
(FlaE) 		3 SER A 152
ALA A 151
THR A 148
 None
 0.73A 5n0xB-3a69A:
undetectable		 5n0xB-3a69A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhi CARBONYL REDUCTASE
[NADPH] 1

(Homo sapiens) 		PF00106
(adh_short) 		3 SER A 191
ALA A 192
THR A 109
 None
 0.63A 5n0xB-3bhiA:
undetectable		 5n0xB-3bhiA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		3 SER A 550
ALA A 551
THR A 557
 None
 0.74A 5n0xB-3bjcA:
undetectable		 5n0xB-3bjcA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr2 EXPORTED
GLUCONOLACTONASE

(Xanthomonas
campestris) 		PF08450
(SGL) 		3 SER A 280
ALA A 279
THR A 275
 None
 0.67A 5n0xB-3dr2A:
undetectable		 5n0xB-3dr2A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza sativa) 		PF07859
(Abhydrolase_3) 		3 SER A 293
ALA A 324
THR A 334
 None
 0.76A 5n0xB-3eblA:
1.1		 5n0xB-3eblA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		3 SER A 240
ALA A 241
THR A  80
 None
 0.69A 5n0xB-3egwA:
1.2		 5n0xB-3egwA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		3 SER A 401
ALA A 402
THR A 354
 None
 0.62A 5n0xB-3f41A:
undetectable		 5n0xB-3f41A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ico 6-PHOSPHOGLUCONOLACT
ONASE

(Mycobacterium
tuberculosis) 		PF01182
(Glucosamine_iso) 		3 SER A 160
ALA A 162
THR A 185
 None
 0.75A 5n0xB-3icoA:
undetectable		 5n0xB-3icoA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io0 ETUB PROTEIN

(Clostridium
kluyveri) 		PF00936
(BMC) 		3 SER A 287
ALA A 284
THR A 237
 None
 0.65A 5n0xB-3io0A:
undetectable		 5n0xB-3io0A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A  28
ALA A  29
THR A 297
 None
 0.62A 5n0xB-3kumA:
undetectable		 5n0xB-3kumA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luf TWO-COMPONENT SYSTEM
RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN

(Aeromonas
salmonicida) 		PF00072
(Response_reg) 		3 SER A 153
ALA A 152
THR A 161
 None
 0.70A 5n0xB-3lufA:
2.5		 5n0xB-3lufA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhu DIHYDROOROTATE
DEHYDROGENASE

(Leishmania
major) 		PF01180
(DHO_dh) 		3 SER A  36
ALA A  37
THR A 287
 None
 0.56A 5n0xB-3mhuA:
undetectable		 5n0xB-3mhuA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7x CAPSID PROTEIN

(Decapod
penstyldensovirus
1) 		PF16530
(IHHNV_capsid) 		3 SER A  92
ALA A  93
THR A 227
 None
 0.55A 5n0xB-3n7xA:
undetectable		 5n0xB-3n7xA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nro LMO1026 PROTEIN

(Listeria
monocytogenes) 		PF03816
(LytR_cpsA_psr) 		3 SER A  80
ALA A  91
THR A 139
 None
 0.69A 5n0xB-3nroA:
undetectable		 5n0xB-3nroA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aspergillus
nidulans) 		PF01179
(Cu_amine_oxid)
PF09248
(DUF1965) 		3 SER A 499
ALA A 432
THR A 450
 None
 0.69A 5n0xB-3pgbA:
undetectable		 5n0xB-3pgbA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo6 PROTEASE DO-LIKE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		3 SER A 260
ALA A 261
THR A 298
 None
 0.75A 5n0xB-3qo6A:
undetectable		 5n0xB-3qo6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE

(Helicobacter
pylori) 		PF01370
(Epimerase) 		3 SER A 138
ALA A 139
THR A 291
 NAD  A2402 (-3.3A)
None
None
 0.41A 5n0xB-3sxpA:
undetectable		 5n0xB-3sxpA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF) 		3 SER A 500
ALA A 501
THR A 549
 None
 0.71A 5n0xB-3t6gA:
undetectable		 5n0xB-3t6gA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1s FAB PGT145 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  25
ALA H  24
THR H  94
 None
 0.70A 5n0xB-3u1sH:
undetectable		 5n0xB-3u1sH:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u92 GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		3 SER A 122
ALA A 123
THR A 153
 None
 0.73A 5n0xB-3u92A:
undetectable		 5n0xB-3u92A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbo GENOME POLYPROTEIN,
CAPSID PROTEIN VP2

(Enterovirus A) 		PF00073
(Rhv) 		3 SER B 274
ALA B 275
THR B 156
 None
 0.53A 5n0xB-3vboB:
undetectable		 5n0xB-3vboB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		3 SER A 115
ALA A 114
THR A 256
 None
 0.64A 5n0xB-3vv3A:
undetectable		 5n0xB-3vv3A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 SER A 149
ALA A 150
THR A 206
 None
 0.67A 5n0xB-3zu0A:
undetectable		 5n0xB-3zu0A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 SER A 199
ALA A 198
THR A 299
 None
 0.68A 5n0xB-3zz1A:
undetectable		 5n0xB-3zz1A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap3 STEROID
MONOOXYGENASE

(Rhodococcus
rhodochrous) 		PF00743
(FMO-like) 		3 SER A 269
ALA A 270
THR A 309
 None
 0.60A 5n0xB-4ap3A:
undetectable		 5n0xB-4ap3A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyl EFF-1A

(Caenorhabditis
elegans) 		PF14884
(EFF-AFF) 		3 SER A 241
ALA A 240
THR A 187
 None
 0.76A 5n0xB-4cylA:
undetectable		 5n0xB-4cylA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		3 SER A 559
ALA A 524
THR A 531
 None
FUC  A2007 ( 4.0A)
None
 0.65A 5n0xB-4d72A:
undetectable		 5n0xB-4d72A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E

(Burkholderia
thailandensis) 		PF01370
(Epimerase) 		3 SER A 116
ALA A 117
THR A 296
 NAP  A 401 (-3.3A)
None
None
 0.35A 5n0xB-4ej0A:
undetectable		 5n0xB-4ej0A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu8 GH10 XYLANASE

(Globitermes
brachycerastes) 		PF00331
(Glyco_hydro_10)
PF02368
(Big_2) 		3 SER A  59
ALA A  58
THR A 105
 None
 0.74A 5n0xB-4hu8A:
undetectable		 5n0xB-4hu8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihb DYSFERLIN

(Homo sapiens) 		PF00168
(C2) 		3 SER A 100
ALA A  99
THR A  94
 FMT  A 202 ( 4.7A)
None
None
 0.73A 5n0xB-4ihbA:
undetectable		 5n0xB-4ihbA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzy 40S RIBOSOMAL
PROTEIN S2

(Oryctolagus
cuniculus) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		3 SER C 210
ALA C 211
THR C 215
 U  i1150 ( 4.4A)
C  i   4 ( 3.4A)
U  i   5 ( 3.4A)
 0.69A 5n0xB-4kzyC:
undetectable		 5n0xB-4kzyC:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m00 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		3 SER A 549
ALA A 548
THR A 497
 None
 0.69A 5n0xB-4m00A:
undetectable		 5n0xB-4m00A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m01 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		no annotation 3 SER A 549
ALA A 548
THR A 497
 None
 0.74A 5n0xB-4m01A:
undetectable		 5n0xB-4m01A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m02 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		3 SER A 549
ALA A 548
THR A 497
 None
 0.73A 5n0xB-4m02A:
undetectable		 5n0xB-4m02A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx9 FLAGELLIN

(Pseudomonas
aeruginosa) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C) 		3 SER A 248
ALA A 247
THR A 171
 None
 0.74A 5n0xB-4nx9A:
undetectable		 5n0xB-4nx9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovx XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

(Planctopirus
limnophila) 		PF01261
(AP_endonuc_2) 		3 SER A 250
ALA A 251
THR A 301
 None
 0.33A 5n0xB-4ovxA:
undetectable		 5n0xB-4ovxA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvr UNCHARACTERIZED
HYPOTHETICAL PROTEIN
FTT_1539C

(Francisella
tularensis) 		no annotation 3 SER A  69
ALA A  70
THR A 100
 None
 0.47A 5n0xB-4qvrA:
undetectable		 5n0xB-4qvrA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tt1 DENEDDYLASE

(Human
alphaherpesvirus
1) 		no annotation 3 SER A1703
ALA A1702
THR A1711
 None
 0.71A 5n0xB-4tt1A:
undetectable		 5n0xB-4tt1A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6w NBFEDF6

(Lama glama) 		PF07686
(V-set) 		3 SER B 825
ALA B 824
THR B 897
 None
 0.74A 5n0xB-4w6wB:
undetectable		 5n0xB-4w6wB:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		3 SER A1418
ALA A1419
THR A1450
 None
 0.61A 5n0xB-4wxxA:
2.9		 5n0xB-4wxxA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy9 PUTATIVE MCP-TYPE
SIGNAL TRANSDUCTION
PROTEIN

(Campylobacter
jejuni) 		PF02743
(dCache_1) 		3 SER A 290
ALA A 289
THR A 314
 ACT  A 401 (-2.5A)
ACT  A 401 (-3.5A)
None
 0.55A 5n0xB-4wy9A:
undetectable		 5n0xB-4wy9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y8d NANOBODY

(Lama glama) 		PF07686
(V-set) 		3 SER C  25
ALA C  24
THR C  95
 None
 0.68A 5n0xB-4y8dC:
undetectable		 5n0xB-4y8dC:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yvs CAPSID PROTEIN VP0

(Enterovirus A) 		PF00073
(Rhv) 		3 SER C 205
ALA C 206
THR C  87
 None
 0.68A 5n0xB-4yvsC:
undetectable		 5n0xB-4yvsC:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abj VP2

(Enterovirus A) 		PF00073
(Rhv) 		3 SER B 205
ALA B 206
THR B  87
 None
 0.62A 5n0xB-5abjB:
undetectable		 5n0xB-5abjB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		3 SER A 399
ALA A 400
THR A 427
 None
 0.74A 5n0xB-5bs5A:
undetectable		 5n0xB-5bs5A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT

(Streptomyces) 		PF04820
(Trp_halogenase) 		3 SER A 305
ALA A  53
THR A  96
 None
 0.68A 5n0xB-5bulA:
undetectable		 5n0xB-5bulA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8c VP0

(Enterovirus A) 		PF00073
(Rhv)
PF02226
(Pico_P1A) 		3 SER B 274
ALA B 275
THR B 156
 None
 0.58A 5n0xB-5c8cB:
undetectable		 5n0xB-5c8cB:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1) 		3 SER B 455
ALA B 454
THR B 463
 None
 0.74A 5n0xB-5d9aB:
undetectable		 5n0xB-5d9aB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4m HYDROXYNITRILE LYASE

(Davallia
tyermannii) 		no annotation 3 SER A  77
ALA A  76
THR A 109
 None
 0.72A 5n0xB-5e4mA:
undetectable		 5n0xB-5e4mA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		3 SER A 141
ALA A 175
THR A 180
 None
 0.71A 5n0xB-5fbzA:
1.0		 5n0xB-5fbzA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		3 SER A 231
ALA A 228
THR A   3
 None
None
OCS  A   2 ( 3.8A)
 0.73A 5n0xB-5hkeA:
undetectable		 5n0xB-5hkeA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4u GLUTATHIONE
TRANSFERASE FAMILY
PROTEIN

(Populus
trichocarpa) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		3 SER A  82
ALA A  83
THR A 150
 None
 0.76A 5n0xB-5j4uA:
undetectable		 5n0xB-5j4uA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5js9 GP41

(Human
immunodeficiency
virus 1) 		PF00517
(GP41) 		3 SER D 528
ALA D 525
THR D 536
 None
 0.70A 5n0xB-5js9D:
undetectable		 5n0xB-5js9D:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzd ISOCHORISMATE
SYNTHASE ENTC

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		3 SER A  87
ALA A  77
THR A 345
 None
 0.69A 5n0xB-5jzdA:
undetectable		 5n0xB-5jzdA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		3 SER A  41
ALA A  42
THR A 222
 None
 0.70A 5n0xB-5laeA:
undetectable		 5n0xB-5laeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb8 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		3 SER A 339
ALA A 341
THR A 194
 None
 0.70A 5n0xB-5lb8A:
undetectable		 5n0xB-5lb8A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfd ALLANTOIN RACEMASE

(Pseudomonas
fluorescens) 		no annotation 3 SER A 142
ALA A 141
THR A 119
 None
 0.71A 5n0xB-5lfdA:
2.6		 5n0xB-5lfdA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		3 SER A1289
ALA A1290
THR A1322
 None
 0.70A 5n0xB-5lkzA:
undetectable		 5n0xB-5lkzA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 SER A 270
ALA A 269
THR A 174
 None
 0.60A 5n0xB-5lm8A:
undetectable		 5n0xB-5lm8A:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n0o PEPTIDE
N-METHYLTRANSFERASE

(Omphalotus
olearius) 		no annotation 3 SER A 129
ALA A 130
THR A 245
 SAM  A 501 (-4.7A)
SAM  A 501 (-3.2A)
SAM  A 501 (-3.6A)
 0.00A 5n0xB-5n0oA:
45.7		 5n0xB-5n0oA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj2 MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1

(Gallus gallus) 		PF13927
(Ig_3) 		3 SER A 625
ALA A 626
THR A 719
 None
 0.69A 5n0xB-5oj2A:
undetectable		 5n0xB-5oj2A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy9 GLYCOPROTEIN G

(Indiana
vesiculovirus) 		no annotation 3 SER A 260
ALA A 261
THR A 312
 None
 0.67A 5n0xB-5oy9A:
undetectable		 5n0xB-5oy9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE

(Streptomyces
platensis) 		PF13714
(PEP_mutase) 		3 SER A 235
ALA A 236
THR A  33
 None
 0.73A 5n0xB-5uncA:
undetectable		 5n0xB-5uncA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans) 		PF03639
(Glyco_hydro_81) 		3 SER A 318
ALA A 317
THR A 286
 None
None
EDO  A 818 (-4.2A)
 0.74A 5n0xB-5v1wA:
undetectable		 5n0xB-5v1wA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		3 SER A 267
ALA A 268
THR A 304
 None
None
FAD  A 503 (-2.0A)
 0.73A 5n0xB-5vj7A:
undetectable		 5n0xB-5vj7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9s METHYLPHOSPHONATE
SYNTHASE

(Nitrosopumilus
maritimus) 		no annotation 3 SER A 245
ALA A 242
THR A 307
 None
 0.75A 5n0xB-6b9sA:
undetectable		 5n0xB-6b9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1

(Saccharomyces
cerevisiae) 		no annotation 3 SER A  19
ALA A  20
THR A 255
 None
 0.65A 5n0xB-6f42A:
undetectable		 5n0xB-6f42A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis) 		no annotation 3 SER A  97
ALA A  96
THR A 238
 None
NA  A 402 ( 4.7A)
None
 0.57A 5n0xB-6f9mA:
1.6		 5n0xB-6f9mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 3 SER A1218
ALA A1217
THR A1202
 None
 0.53A 5n0xB-6fikA:
1.8		 5n0xB-6fikA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL

(endosymbiont of
Tevnia
jerichonana) 		no annotation 3 SER A 183
ALA A 182
THR A 178
 None
 0.69A 5n0xB-6fvsA:
undetectable		 5n0xB-6fvsA:
undetectable