SIMILAR PATTERNS OF AMINO ACIDS FOR 5N0T_B_SAMB501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jpf HYPOTHETICAL PROTEIN

(Bordetella
parapertussis) 		PF11516
(DUF3220) 		4 TYR A  63
SER A  58
GLN A  88
THR A  93
 None
 1.17A 5n0tB-2jpfA:
undetectable		 5n0tB-2jpfA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 TYR A1093
SER A1150
GLN A1208
THR A1206
 None
 1.48A 5n0tB-2np0A:
0.0		 5n0tB-2np0A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsu PUTATIVE FIBER
PROTEIN

(Porcine
mastadenovirus
B) 		PF00337
(Gal-bind_lectin) 		4 TYR A 487
SER A 452
GLN A 504
THR A 427
 None
 1.46A 5n0tB-2wsuA:
0.0		 5n0tB-2wsuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 4 TYR A 328
SER A 325
GLN A  74
THR A  65
 None
 1.38A 5n0tB-3ahmA:
0.0		 5n0tB-3ahmA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae;
Homo sapiens) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 TYR A 367
SER A 387
GLN A 379
THR A 216
 None
 1.39A 5n0tB-3fjoA:
0.9		 5n0tB-3fjoA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 TYR A 502
SER A 450
GLN A 416
THR A 415
 None
 1.31A 5n0tB-3hs0A:
0.0		 5n0tB-3hs0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tj0 NUCLEOPROTEIN

(Influenza B
virus) 		PF00506
(Flu_NP) 		4 TYR A 363
SER A 436
GLN A 440
THR A 406
 None
 1.47A 5n0tB-3tj0A:
0.2		 5n0tB-3tj0A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita) 		PF00300
(His_Phos_1) 		4 TYR A  86
SER A  66
GLN A  73
THR A  74
 None
 1.30A 5n0tB-4hbzA:
3.9		 5n0tB-4hbzA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00659
(POLO_box) 		4 TYR B 573
SER B 569
GLN B 527
THR B 530
 None
 1.48A 5n0tB-4j7bB:
0.0		 5n0tB-4j7bB:
19.52