SIMILAR PATTERNS OF AMINO ACIDS FOR 5N0S_B_SAMB501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 GLY A 192
ALA A 190
MET A 109
THR A 158
 None
 1.22A 5n0sB-1brwA:
0.5		 5n0sB-1brwA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))

(Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10) 		4 GLY L 123
ALA L 113
MET L 391
THR L 260
 None
None
CYS  L 432 (-3.7A)
None
 1.34A 5n0sB-1hfeL:
0.8		 5n0sB-1hfeL:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htp H-PROTEIN

(Pisum sativum) 		PF01597
(GCV_H) 		4 GLY A  55
ALA A  58
MET A 100
THR A  65
 None
 1.46A 5n0sB-1htpA:
undetectable		 5n0sB-1htpA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		4 GLY A 475
ALA A 142
MET A  80
THR A  93
 None
 1.32A 5n0sB-1m7jA:
0.0		 5n0sB-1m7jA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE

(Enterobacter
cloacae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 419
ALA A 415
MET A 448
THR A 441
 None
 1.41A 5n0sB-1ovmA:
0.0		 5n0sB-1ovmA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1php 3-PHOSPHOGLYCERATE
KINASE

(Geobacillus
stearothermophilus) 		PF00162
(PGK) 		4 GLY A 372
ALA A 148
MET A 171
THR A 156
 None
 1.23A 5n0sB-1phpA:
1.5		 5n0sB-1phpA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		4 GLY A 173
ALA A 194
MET A 201
THR A 234
 None
 1.42A 5n0sB-1pz3A:
0.0		 5n0sB-1pz3A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpx PROTEIN
(TRANSALDOLASE (EC
2.2.1.2))

(Thermotoga
maritima) 		PF00923
(TAL_FSA) 		4 GLY A 131
ALA A 163
MET A 143
THR A 107
 None
 1.49A 5n0sB-1vpxA:
0.2		 5n0sB-1vpxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsj RIBONUCLEASE HI

(Escherichia
coli) 		PF00075
(RNase_H) 		4 GLY A  23
ALA A  37
MET A  47
THR A 145
 None
 1.43A 5n0sB-1wsjA:
0.0		 5n0sB-1wsjA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF01134
(GIDA) 		4 GLY A 122
ALA A 120
MET A  40
THR A  18
 FAD  A 301 (-3.2A)
None
None
None
 1.27A 5n0sB-2culA:
undetectable		 5n0sB-2culA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmu PUTATIVE
PYRIDOXAMINE
5-PHOSPHATE-DEPENDEN
T DEHYDRASE, WBDK

(Escherichia
coli) 		PF01041
(DegT_DnrJ_EryC1) 		4 GLY A 195
ALA A 191
MET A 164
THR A  10
 None
 1.29A 5n0sB-2gmuA:
undetectable		 5n0sB-2gmuA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imh HYPOTHETICAL PROTEIN
UNP Q5LQD5_SILPO

(Ruegeria
pomeroyi) 		PF06267
(DUF1028) 		4 GLY A  17
ALA A  19
MET A 129
THR A   2
 None
 1.23A 5n0sB-2imhA:
undetectable		 5n0sB-2imhA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imh HYPOTHETICAL PROTEIN
UNP Q5LQD5_SILPO

(Ruegeria
pomeroyi) 		PF06267
(DUF1028) 		4 GLY A  17
ALA A  19
MET A 129
THR A  21
 None
 1.23A 5n0sB-2imhA:
undetectable		 5n0sB-2imhA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvd FERREDOXIN-THIOREDOX
IN REDUCTASE,
CATALYTIC CHAIN

(Synechocystis
sp.) 		PF02943
(FeThRed_B) 		4 GLY A  42
ALA A  37
MET A 116
THR A 108
 None
 1.30A 5n0sB-2pvdA:
undetectable		 5n0sB-2pvdA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 GLY A 137
ALA A 510
MET A  48
THR A 148
 None
 1.14A 5n0sB-2yikA:
undetectable		 5n0sB-2yikA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2k TRNA(ILE)-LYSIDINE
SYNTHASE

(Geobacillus
kaustophilus) 		PF01171
(ATP_bind_3)
PF09179
(TilS)
PF11734
(TilS_C) 		4 GLY A 333
ALA A 330
MET A 418
THR A 327
 None
 1.47A 5n0sB-3a2kA:
2.4		 5n0sB-3a2kA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5p PROTEIN BAS0735 OF
UNKNOWN FUNCTION

(Bacillus
anthracis) 		PF11579
(DUF3238) 		4 GLY A  89
ALA A  91
MET A  47
THR A  93
 None
 1.49A 5n0sB-3c5pA:
undetectable		 5n0sB-3c5pA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 307
ALA A  16
MET A 314
THR A  30
 None
 1.36A 5n0sB-3cgdA:
undetectable		 5n0sB-3cgdA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5q PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Staphylococcus
aureus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 GLY A 192
ALA A 190
MET A 109
THR A 158
 None
 1.46A 5n0sB-3h5qA:
undetectable		 5n0sB-3h5qA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE

(Bacillus
subtilis) 		PF01593
(Amino_oxidase) 		4 GLY A  57
ALA A 356
MET A 403
THR A 348
 None
 1.16A 5n0sB-3i6dA:
undetectable		 5n0sB-3i6dA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Streptococcus
pyogenes) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLY A 208
ALA A 206
MET A 186
THR A 169
 None
 1.40A 5n0sB-3lgxA:
undetectable		 5n0sB-3lgxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Toxoplasma
gondii) 		PF01048
(PNP_UDP_1) 		4 GLY A  28
ALA A  94
MET A 189
THR A 239
 PO4  A 281 (-3.2A)
None
None
None
 1.49A 5n0sB-3mb8A:
1.8		 5n0sB-3mb8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nn2 CHLORITE DISMUTASE

(Nitrospira
defluvii) 		PF06778
(Chlor_dismutase) 		4 GLY A  98
ALA A  17
MET A  87
THR A  15
 None
 1.41A 5n0sB-3nn2A:
undetectable		 5n0sB-3nn2A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 GLY A 511
ALA A 195
MET A 459
THR A 357
 None
 0.99A 5n0sB-3p4sA:
undetectable		 5n0sB-3p4sA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubg NEURAL-CADHERIN

(Drosophila
melanogaster) 		PF00028
(Cadherin) 		4 GLY A 598
ALA A 569
MET A 550
THR A 635
 None
 1.45A 5n0sB-3ubgA:
undetectable		 5n0sB-3ubgA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uma HYPOTHETICAL
PEROXIREDOXIN
PROTEIN

(Sinorhizobium
meliloti) 		PF08534
(Redoxin) 		4 GLY A   6
ALA A   4
MET A 130
THR A   2
 None
 1.23A 5n0sB-3umaA:
undetectable		 5n0sB-3umaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwd PHOSPHOGLYCERATE
KINASE

(Bacillus
anthracis) 		PF00162
(PGK) 		4 GLY A 372
ALA A 148
MET A 171
THR A 156
 None
 1.33A 5n0sB-3uwdA:
2.0		 5n0sB-3uwdA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Thermococcus
kodakarensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 GLY A 297
ALA A 290
MET A 277
THR A 210
 None
 1.17A 5n0sB-3wjpA:
undetectable		 5n0sB-3wjpA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c76 FMN REDUCTASE
(NADPH)

(Pseudomonas
putida) 		PF03358
(FMN_red) 		4 GLY A 145
ALA A 114
MET A 125
THR A  21
 PGE  A 206 (-4.7A)
None
None
None
 1.43A 5n0sB-4c76A:
undetectable		 5n0sB-4c76A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 GLY A 193
ALA A 111
MET A 105
THR A 248
 ALF  A1001 (-3.1A)
GDP  A1003 (-4.1A)
None
GDP  A1003 ( 4.4A)
 1.49A 5n0sB-4c7oA:
5.6		 5n0sB-4c7oA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezb UNCHARACTERIZED
CONSERVED PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		4 GLY A  21
ALA A  25
MET A 156
THR A   2
 None
 1.36A 5n0sB-4ezbA:
undetectable		 5n0sB-4ezbA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		4 GLY A 109
ALA A 330
MET A 294
THR A 285
 None
 1.09A 5n0sB-4hxyA:
undetectable		 5n0sB-4hxyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyv PYRUVATE KINASE 1

(Trypanosoma
brucei) 		PF00224
(PK)
PF02887
(PK_C) 		4 GLY A  80
ALA A  49
MET A  42
THR A  64
 None
 1.21A 5n0sB-4hyvA:
undetectable		 5n0sB-4hyvA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5i TRANSCRIPTIONAL
REGULATOR LSRR

(Escherichia
coli) 		PF04198
(Sugar-bind) 		4 GLY A 281
ALA A 283
MET A 296
THR A 310
 None
 1.23A 5n0sB-4l5iA:
undetectable		 5n0sB-4l5iA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 GLY A 291
ALA A 325
MET A 340
THR A 367
 None
 1.00A 5n0sB-4lihA:
undetectable		 5n0sB-4lihA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 GLY A 197
ALA A 195
MET A 192
THR A 354
 None
 1.38A 5n0sB-4lq1A:
undetectable		 5n0sB-4lq1A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okr MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		4 GLY A 217
ALA A 247
MET A 186
THR A 254
 None
 1.10A 5n0sB-4okrA:
undetectable		 5n0sB-4okrA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou4 ALPHA/BETA HYDROLASE
FOLD-3 DOMAIN
PROTEIN

(Pseudomonas sp.
ECU1011) 		PF07859
(Abhydrolase_3) 		4 GLY A 143
ALA A 140
MET A  82
THR A 177
 None
 1.28A 5n0sB-4ou4A:
undetectable		 5n0sB-4ou4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0c ABGT PUTATIVE
TRANSPORTER FAMILY

(Alcanivorax
borkumensis) 		PF03806
(ABG_transport) 		4 GLY A  84
ALA A  81
MET A 341
THR A 188
 None
 1.00A 5n0sB-4r0cA:
undetectable		 5n0sB-4r0cA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf7 CARBOHYDRATE/PYRIMID
INE KINASE, PFKB
FAMILY

(Thermococcus
kodakarensis) 		no annotation 4 GLY A 227
ALA A 224
MET A 258
THR A 245
 None
None
None
ACP  A 302 (-3.8A)
 1.49A 5n0sB-4xf7A:
undetectable		 5n0sB-4xf7A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2w HYPOTHETICAL (DI
HEME) PROTEIN

(Candidatus
Kuenenia
stuttgartiensis) 		PF00034
(Cytochrom_C) 		4 GLY C 197
ALA C 352
MET C 234
THR C 208
 None
 1.31A 5n0sB-5c2wC:
undetectable		 5n0sB-5c2wC:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8y SULFITE REDUCTASE
[FERREDOXIN],
CHLOROPLASTIC

(Zea mays) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLY A 553
ALA A 576
MET A 319
THR A 574
 None
 1.05A 5n0sB-5h8yA:
undetectable		 5n0sB-5h8yA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrm HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 4 GLY A 473
ALA A 494
MET A 543
THR A 539
 None
 1.19A 5n0sB-5hrmA:
undetectable		 5n0sB-5hrmA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioj HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 4 GLY A 473
ALA A 494
MET A 543
THR A 539
 None
 1.24A 5n0sB-5iojA:
undetectable		 5n0sB-5iojA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsq AMINOPEPTIDASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00883
(Peptidase_M17) 		4 GLY A 314
ALA A 497
MET A 309
THR A 403
 None
 1.50A 5n0sB-5nsqA:
undetectable		 5n0sB-5nsqA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veh KYNURENINE
AMINOTRANSFERASE

(Aedes aegypti) 		no annotation 4 GLY A 120
ALA A 116
MET A 141
THR A 107
 None
 1.37A 5n0sB-5vehA:
1.5		 5n0sB-5vehA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
SMALL SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 4 GLY A  72
ALA A  70
MET A  18
THR A  65
 None
 1.47A 5n0sB-5y6qA:
undetectable		 5n0sB-5y6qA:
undetectable