SIMILAR PATTERNS OF AMINO ACIDS FOR 5N0S_B_SAMB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f59 IMPORTIN BETA-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 ILE A 157
VAL A 134
VAL A 137
ILE A 116
ALA A 117
 None
 0.92A 5n0sB-1f59A:
0.0		 5n0sB-1f59A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		5 ILE A  57
VAL A 262
VAL A 282
ILE A  12
VAL A  20
 None
 1.07A 5n0sB-1gynA:
undetectable		 5n0sB-1gynA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1huq RAB5C

(Mus musculus) 		PF00071
(Ras) 		5 VAL A  70
PHE A  22
GLN A  95
ILE A 129
ALA A 130
 None
 1.11A 5n0sB-1huqA:
undetectable		 5n0sB-1huqA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF00215
(OMPdecase) 		5 HIS A 128
TYR A 206
ILE A 205
ALA A 203
VAL A 201
 None
None
None
UP6  A5001 (-3.3A)
UP6  A5001 ( 4.5A)
 1.11A 5n0sB-1losA:
undetectable		 5n0sB-1losA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nh9 DNA-BINDING PROTEIN
ALBA

(Methanocaldococcus
jannaschii) 		PF01918
(Alba) 		5 ILE A   7
VAL A   4
VAL A  29
ILE A  38
ALA A  37
 None
 1.14A 5n0sB-1nh9A:
undetectable		 5n0sB-1nh9A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ILE B 275
SER B 271
ILE B 317
ALA B 316
VAL B 295
 None
 1.05A 5n0sB-1pjmB:
undetectable		 5n0sB-1pjmB:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 ILE A 157
VAL A 134
VAL A 137
ILE A 116
ALA A 117
 None
 0.91A 5n0sB-1qgrA:
undetectable		 5n0sB-1qgrA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 ILE A 157
VAL A 137
GLN A 132
ILE A 116
ALA A 117
 None
 1.03A 5n0sB-1qgrA:
undetectable		 5n0sB-1qgrA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7g NAD-DEPENDENT
DEACETYLASE 2

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		5 VAL A 189
PHE A  21
VAL A  20
ILE A  32
ALA A  28
 None
None
None
1PE  A 504 ( 4.7A)
NAD  A 703 ( 3.7A)
 0.92A 5n0sB-1s7gA:
0.6		 5n0sB-1s7gA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE

(Thermus
thermophilus) 		PF00697
(PRAI) 		5 ILE A 150
VAL A  56
VAL A  54
ILE A 155
ALA A 152
 None
 1.10A 5n0sB-1v5xA:
undetectable		 5n0sB-1v5xA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi6 EXTRAGENIC
SUPPRESSOR

(Pyrococcus
furiosus) 		PF00459
(Inositol_P) 		5 ILE A  82
VAL A  72
VAL A  70
ILE A 203
ALA A 204
 None
 1.11A 5n0sB-1xi6A:
undetectable		 5n0sB-1xi6A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkd DUF185

(Rhodopseudomonas
palustris) 		PF02636
(Methyltransf_28) 		5 ILE A  87
HIS A 140
VAL A 146
ILE A 240
ALA A 155
 None
 0.93A 5n0sB-1zkdA:
undetectable		 5n0sB-1zkdA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		5 ILE A 182
HIS A 143
PHE A  93
VAL A  95
ALA A 208
 None
None
EDO  A 404 ( 4.6A)
None
None
 1.02A 5n0sB-2ashA:
undetectable		 5n0sB-2ashA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 VAL A 304
VAL A 301
ILE A 324
ALA A 321
VAL A 126
 None
 1.15A 5n0sB-2bpqA:
undetectable		 5n0sB-2bpqA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyj HYPOTHETICAL PROTEIN
PH1505

(Pyrococcus
horikoshii) 		PF04430
(DUF498) 		5 ILE A 113
VAL A  84
PHE A  61
TYR A  25
ILE A  24
 None
 1.13A 5n0sB-2cyjA:
undetectable		 5n0sB-2cyjA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus) 		PF02171
(Piwi) 		5 ILE A 395
VAL A 420
SER A 358
TYR A 427
ALA A 397
 None
 1.09A 5n0sB-2f8tA:
undetectable		 5n0sB-2f8tA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151

(Pyrobaculum
aerophilum) 		PF01850
(PIN) 		5 ILE A  10
VAL A  27
TYR A 103
ALA A  39
VAL A  77
 None
 1.15A 5n0sB-2fe1A:
undetectable		 5n0sB-2fe1A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fim TUBBY RELATED
PROTEIN 1

(Homo sapiens) 		PF01167
(Tub) 		5 VAL A 430
PHE A 426
GLN A 439
ILE A 477
ALA A 478
 None
 1.04A 5n0sB-2fimA:
undetectable		 5n0sB-2fimA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiq PUTATIVE TAGATOSE
6-PHOSPHATE KINASE 1

(Escherichia
coli) 		PF08013
(Tagatose_6_P_K) 		5 ILE A 349
HIS A 355
VAL A 318
VAL A 314
TYR A 330
 None
 1.14A 5n0sB-2fiqA:
undetectable		 5n0sB-2fiqA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0r NICOTINAMIDASE

(Saccharomyces
cerevisiae) 		PF00857
(Isochorismatase) 		5 ILE A 192
VAL A 198
VAL A 202
SER A 193
TYR A  70
 None
 1.10A 5n0sB-2h0rA:
1.4		 5n0sB-2h0rA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i99 MU-CRYSTALLIN
HOMOLOG

(Homo sapiens) 		PF02423
(OCD_Mu_crystall) 		5 ILE A 154
VAL A 114
SER A 150
ILE A 126
ALA A 125
 None
 1.02A 5n0sB-2i99A:
undetectable		 5n0sB-2i99A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibb CG9211-PA

(Drosophila
melanogaster) 		PF00041
(fn3) 		5 ILE A 631
HIS A 598
VAL A 596
VAL A 595
SER A 638
 None
 1.18A 5n0sB-2ibbA:
undetectable		 5n0sB-2ibbA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgq TRIOSEPHOSPHATE
ISOMERASE

(Helicobacter
pylori) 		PF00121
(TIM) 		5 ILE A 230
VAL A  37
VAL A  39
ILE A 206
ALA A 203
 None
 1.16A 5n0sB-2jgqA:
undetectable		 5n0sB-2jgqA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n57 ACYL CARRIER PROTEIN

(Brucella
melitensis) 		PF00550
(PP-binding) 		5 ILE A  63
VAL A   8
VAL A  12
ALA A  59
VAL A  41
 None
 1.11A 5n0sB-2n57A:
undetectable		 5n0sB-2n57A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2od4 HYPOTHETICAL PROTEIN

(uncultured
marine organism) 		no annotation 5 ILE A  60
VAL A  79
VAL A  82
ILE A  39
ALA A  43
 CL  A 101 ( 4.0A)
None
None
None
None
 1.16A 5n0sB-2od4A:
undetectable		 5n0sB-2od4A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 GLN A  60
TYR A  89
ILE A 291
ALA A 290
VAL A  58
 None
 1.18A 5n0sB-2po4A:
undetectable		 5n0sB-2po4A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkb RIBONUCLEASE H1

(Homo sapiens) 		PF00075
(RNase_H) 		5 ILE A 202
HIS A 135
GLN A 257
ILE A 194
ALA A 197
 None
 1.13A 5n0sB-2qkbA:
undetectable		 5n0sB-2qkbA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qps ALPHA-AMYLASE TYPE A
ISOZYME

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		5 ILE A 368
VAL A 385
PHE A 390
ILE A 342
VAL A 401
 None
 1.04A 5n0sB-2qpsA:
undetectable		 5n0sB-2qpsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8w AGR_C_1641P

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		5 ILE A 289
PHE A 273
ILE A 295
ALA A 293
VAL A 318
 None
 1.06A 5n0sB-2r8wA:
undetectable		 5n0sB-2r8wA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ree CURA

(Moorea
producens) 		PF00583
(Acetyltransf_1) 		5 ILE A 273
GLN A 269
TYR A 285
ILE A 284
ALA A 283
 None
 0.90A 5n0sB-2reeA:
undetectable		 5n0sB-2reeA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		5 ILE A 322
VAL A 327
SER A 323
ILE A 425
ALA A 427
 None
 0.99A 5n0sB-2rfoA:
undetectable		 5n0sB-2rfoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uur COLLAGEN ALPHA-1(IX)
CHAIN

(Homo sapiens) 		no annotation 5 ILE A 121
PHE A 172
VAL A 173
TYR A  88
ILE A 217
 None
 0.89A 5n0sB-2uurA:
undetectable		 5n0sB-2uurA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1p AQUAPORIN PIP2-7
7


(Komagataella
pastoris) 		PF00230
(MIP) 		5 ILE A  88
PHE A  94
SER A  89
ILE A  68
ALA A  69
 None
 1.16A 5n0sB-2w1pA:
undetectable		 5n0sB-2w1pA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1p AQUAPORIN PIP2-7
7


(Komagataella
pastoris) 		PF00230
(MIP) 		5 PHE A  94
VAL A  96
SER A  89
ILE A  68
ALA A  69
 None
 1.06A 5n0sB-2w1pA:
undetectable		 5n0sB-2w1pA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		5 ILE A 404
VAL A 424
VAL A 423
SER A 426
ILE A 443
 None
None
None
ZN  A1567 ( 4.3A)
None
 1.16A 5n0sB-2w9mA:
undetectable		 5n0sB-2w9mA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnb -

(Sus scrofa) 		PF00777
(Glyco_transf_29) 		5 ILE A 278
VAL A 147
SER A 276
PHE A 292
VAL A 327
 None
None
None
C5P  A1344 (-4.6A)
None
 1.18A 5n0sB-2wnbA:
undetectable		 5n0sB-2wnbA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn1 LGPCA THIOREDOXIN

(synthetic
construct) 		PF00085
(Thioredoxin) 		5 ILE A   3
VAL A  57
PHE A  26
ILE A  44
ALA A  45
 None
 1.08A 5n0sB-2yn1A:
undetectable		 5n0sB-2yn1A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00731
(AIRC) 		5 ILE A  58
VAL A  77
PHE A  55
VAL A  54
VAL A  31
 None
 1.16A 5n0sB-2ywxA:
undetectable		 5n0sB-2ywxA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7c DNA/RNA-BINDING
PROTEIN ALBA

(Pyrococcus
horikoshii) 		PF01918
(Alba) 		5 ILE A  34
PHE A  25
ILE A  50
ALA A  48
VAL A  18
 None
 1.17A 5n0sB-2z7cA:
2.8		 5n0sB-2z7cA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf8 COMPONENT OF
SODIUM-DRIVEN POLAR
FLAGELLAR MOTOR

(Vibrio
alginolyticus) 		PF00691
(OmpA) 		5 VAL A  19
SER A  41
PHE A 144
ILE A 104
ALA A 101
 None
 0.95A 5n0sB-2zf8A:
undetectable		 5n0sB-2zf8A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		5 HIS A 202
VAL A 206
SER A 270
ALA A 284
VAL A 261
 None
 1.18A 5n0sB-2zwvA:
2.5		 5n0sB-2zwvA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		5 ILE A 174
VAL A 242
VAL A 234
ALA A 183
VAL A 246
 None
 1.06A 5n0sB-3auoA:
undetectable		 5n0sB-3auoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brk GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE

(Agrobacterium
tumefaciens) 		PF00483
(NTP_transferase) 		5 ILE X 333
VAL X 323
SER X 321
ILE X 366
ALA X 349
 None
 1.18A 5n0sB-3brkX:
undetectable		 5n0sB-3brkX:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3k ALANINE RACEMASE

(Actinobacillus
succinogenes) 		PF13377
(Peripla_BP_3) 		5 VAL A 104
SER A 239
ILE A  18
ALA A  24
VAL A  15
 None
 1.18A 5n0sB-3c3kA:
3.4		 5n0sB-3c3kA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci2 CHYMOTRYPSIN
INHIBITOR 2

(Hordeum vulgare) 		PF00280
(potato_inhibit) 		5 ILE A  39
VAL A  70
PHE A  69
ALA A  46
VAL A  82
 None
 1.02A 5n0sB-3ci2A:
undetectable		 5n0sB-3ci2A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Burkholderia
pseudomallei) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 VAL A  22
VAL A  23
PHE A 302
ILE A  88
VAL A  56
 None
 1.17A 5n0sB-3dahA:
undetectable		 5n0sB-3dahA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4w PUTATIVE HEXULOSE 6
PHOSPHATE SYNTHASE

(Salmonella
enterica) 		PF00215
(OMPdecase) 		5 VAL A  31
GLN A   4
ILE A 203
ALA A 200
VAL A 186
 None
None
None
None
MLI  A 300 ( 4.6A)
 1.14A 5n0sB-3f4wA:
undetectable		 5n0sB-3f4wA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19

(Rhodobacter
sphaeroides) 		PF01244
(Peptidase_M19) 		5 VAL A 259
VAL A 299
SER A 232
ILE A 310
ALA A 264
 None
 1.06A 5n0sB-3fdgA:
undetectable		 5n0sB-3fdgA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb0 PEPTIDASE T

(Bacillus cereus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A 186
PHE A 246
VAL A 182
ILE A 204
ALA A 203
 None
 1.10A 5n0sB-3gb0A:
undetectable		 5n0sB-3gb0A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum) 		PF00291
(PALP) 		5 ILE A 222
VAL A 276
VAL A 273
ILE A 239
VAL A 241
 None
 1.05A 5n0sB-3iauA:
undetectable		 5n0sB-3iauA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmm UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF04326
(AlbA_2)
PF13749
(HATPase_c_4) 		5 VAL A  31
PHE A  42
ILE A 132
ALA A 131
VAL A  86
 None
 1.16A 5n0sB-3lmmA:
1.1		 5n0sB-3lmmA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		5 ILE A   6
VAL A  40
VAL A  10
ILE A  80
VAL A 251
 None
 1.18A 5n0sB-3mc2A:
undetectable		 5n0sB-3mc2A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Escherichia
coli) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ILE A 125
VAL A 166
SER A 157
ILE A 132
ALA A 129
 None
 1.16A 5n0sB-3mogA:
undetectable		 5n0sB-3mogA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nav TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Vibrio cholerae) 		PF00290
(Trp_syntA) 		5 SER A 136
PHE A 152
ILE A 148
ALA A 143
VAL A 126
 None
 1.03A 5n0sB-3navA:
undetectable		 5n0sB-3navA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 ILE A  18
VAL A 159
ILE A  42
ALA A  46
VAL A  38
 None
 1.13A 5n0sB-3o8lA:
4.2		 5n0sB-3o8lA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 VAL A 159
VAL A 115
ILE A  42
ALA A  46
VAL A  38
 None
 1.17A 5n0sB-3o8lA:
4.2		 5n0sB-3o8lA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toe DNA/RNA-BINDING
PROTEIN ALBA

(Methanothermobacter
thermautotrophicus) 		PF01918
(Alba) 		5 ILE A   9
VAL A   6
VAL A  32
ILE A  41
ALA A  40
 None
 1.06A 5n0sB-3toeA:
2.5		 5n0sB-3toeA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txy ISOCHORISMATASE
FAMILY PROTEIN
FAMILY

(Burkholderia
thailandensis) 		PF00857
(Isochorismatase) 		5 VAL A 185
SER A 154
GLN A 178
ILE A 172
ALA A 168
 None
 1.09A 5n0sB-3txyA:
1.9		 5n0sB-3txyA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		5 ILE A 224
VAL A 221
PHE A 195
SER A 223
ALA A 271
 None
 1.06A 5n0sB-3vv3A:
undetectable		 5n0sB-3vv3A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Nostoc sp. PCC
7120) 		PF01590
(GAF) 		5 ILE A  47
VAL A  26
GLN A 171
ILE A 136
ALA A 152
 None
 1.14A 5n0sB-3w2zA:
undetectable		 5n0sB-3w2zA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa8 CRISPR-ASSOCIATED
PROTEIN, CSE2 FAMILY

(Meiothermus
ruber) 		PF09485
(CRISPR_Cse2) 		5 ILE A 155
SER A  74
GLN A 147
ILE A 110
ALA A 109
 None
 1.16A 5n0sB-3wa8A:
undetectable		 5n0sB-3wa8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bru ATP-DEPENDENT RNA
HELICASE DHH1

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 HIS A 314
VAL A 296
SER A 340
ILE A 371
VAL A 355
 None
 1.12A 5n0sB-4bruA:
undetectable		 5n0sB-4bruA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A

(Homo sapiens) 		PF00995
(Sec1) 		5 ILE A  80
VAL A  83
PHE A 113
VAL A 114
ILE A 135
 None
 1.09A 5n0sB-4bx9A:
undetectable		 5n0sB-4bx9A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4o CARBONYL REDUCTASE
CPCR2

(Candida
parapsilosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 163
VAL A 256
ILE A 187
ALA A 186
VAL A 197
 None
 1.15A 5n0sB-4c4oA:
2.2		 5n0sB-4c4oA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdb PROBABLE PRIMOSOMAL
REPLICATION PROTEIN
N

(Ralstonia
solanacearum) 		no annotation 5 ILE A  51
VAL A  47
SER A  50
ILE A  92
ALA A  53
 None
 1.13A 5n0sB-4fdbA:
undetectable		 5n0sB-4fdbA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k91 D-ALA-D-ALA-CARBOXYP
EPTIDASE

(Pseudomonas
aeruginosa) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 ILE A  97
VAL A  88
VAL A  68
ILE A  50
ALA A  48
 None
 1.15A 5n0sB-4k91A:
undetectable		 5n0sB-4k91A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 ILE A 309
GLN A 398
ILE A 325
ALA A 323
VAL A 391
 None
 1.11A 5n0sB-4kxbA:
undetectable		 5n0sB-4kxbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4laf NAD(P)H
DEHYDROGENASE
(QUINONE)

(Pseudomonas sp.
WBC-3) 		PF03358
(FMN_red) 		5 ILE A   5
VAL A   8
PHE A  80
ILE A 199
ALA A 200
 None
 1.13A 5n0sB-4lafA:
2.1		 5n0sB-4lafA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01425
(Amidase) 		5 HIS A 204
GLN A  86
ILE A  91
ALA A  49
VAL A  81
 None
 1.12A 5n0sB-4n0iA:
undetectable		 5n0sB-4n0iA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0t U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1)
PF16842
(RRM_occluded) 		5 HIS A  69
VAL A  72
ILE A  97
ALA A  93
VAL A 111
 None
 1.17A 5n0sB-4n0tA:
undetectable		 5n0sB-4n0tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A

(Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox) 		5 ILE A 402
PHE A 428
VAL A 416
ILE A 170
ALA A 171
 None
 1.16A 5n0sB-4p1cA:
undetectable		 5n0sB-4p1cA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4piv FATTY ACID SYNTHASE

(Homo sapiens) 		PF08242
(Methyltransf_12)
PF08659
(KR) 		5 ILE A1946
VAL A2018
PHE A2016
ILE A1956
ALA A1952
 None
 1.02A 5n0sB-4pivA:
undetectable		 5n0sB-4pivA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 PHE A 354
SER A 265
GLN A 355
ILE A 173
ALA A 170
 None
 1.15A 5n0sB-4rgjA:
undetectable		 5n0sB-4rgjA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		5 VAL A 168
VAL A 124
ILE A  51
ALA A  55
VAL A  47
 None
 1.18A 5n0sB-4u1rA:
2.4		 5n0sB-4u1rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wat PFRH5

(Plasmodium
falciparum) 		no annotation 5 ILE A 244
HIS A 495
PHE A 494
TYR A 404
ILE A 405
 None
 1.10A 5n0sB-4watA:
undetectable		 5n0sB-4watA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whm UDP-GLUCOSE:ANTHOCYA
NIDIN
3-O-GLUCOSYLTRANSFER
ASE

(Clitoria
ternatea) 		PF00201
(UDPGT) 		5 VAL A 275
VAL A 274
ILE A 375
ALA A 372
VAL A 349
 None
UDP  A1001 ( 4.3A)
None
None
None
 1.17A 5n0sB-4whmA:
undetectable		 5n0sB-4whmA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8q PUTATIVE RETAINING
B-GLYCOSIDASE

(Saccharophagus
degradans) 		PF00150
(Cellulase) 		5 ILE A 224
PHE A  50
SER A  52
TYR A 217
ILE A 216
 None
 1.18A 5n0sB-5a8qA:
undetectable		 5n0sB-5a8qA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF02775
(TPP_enzyme_C)
PF12367
(PFO_beta_C) 		5 ILE B  69
VAL B  39
TYR B 161
ALA B 104
VAL B 109
 None
 1.13A 5n0sB-5b48B:
undetectable		 5n0sB-5b48B:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwa ORNITHINE
DECARBOXYLASE

(Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ILE A 155
VAL A 152
VAL A 191
SER A 195
ALA A 211
 None
 1.11A 5n0sB-5bwaA:
undetectable		 5n0sB-5bwaA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC

(Bacillus
subtilis) 		PF00698
(Acyl_transf_1) 		5 VAL A 271
GLN A 157
ILE A 149
ALA A 150
VAL A 152
 None
BR  A 303 ( 4.6A)
None
None
None
 1.16A 5n0sB-5dz6A:
undetectable		 5n0sB-5dz6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ILE A 129
VAL A  40
VAL A 134
SER A 131
VAL A  96
 None
 1.16A 5n0sB-5fr8A:
undetectable		 5n0sB-5fr8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans) 		PF01580
(FtsK_SpoIIIE) 		5 ILE A1282
HIS A1279
VAL A1408
PHE A1374
VAL A1373
 None
 1.10A 5n0sB-5fv0A:
undetectable		 5n0sB-5fv0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hf4 DISKS LARGE HOMOLOG
4

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 ILE A 412
PHE A 337
VAL A 328
SER A 398
ILE A 307
 None
 0.99A 5n0sB-5hf4A:
undetectable		 5n0sB-5hf4A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3n GREEN FLUORESCENT
PROTEIN,HSDR

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF12008
(EcoR124_C) 		5 ILE A 384
PHE A 391
SER A 386
GLN A 321
ILE A 329
 None
 1.12A 5n0sB-5j3nA:
undetectable		 5n0sB-5j3nA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 5 VAL A 409
SER A 393
ILE A 318
ALA A 317
VAL A 374
 None
 1.18A 5n0sB-5muxA:
undetectable		 5n0sB-5muxA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n0o PEPTIDE
N-METHYLTRANSFERASE

(Omphalotus
olearius) 		no annotation 12 ILE A  19
HIS A 100
VAL A 103
PHE A 104
VAL A 105
SER A 129
PHE A 171
GLN A 172
TYR A 211
ILE A 212
ALA A 213
VAL A 243
 SAM  A 501 (-4.5A)
None
SAM  A 501 (-4.4A)
None
None
SAM  A 501 (-4.7A)
SAM  A 501 (-4.3A)
HSE  A 504 ( 3.3A)
SAM  A 501 (-4.7A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.0A)
 0.24A 5n0sB-5n0oA:
21.8		 5n0sB-5n0oA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 6 ILE A1087
PHE A1066
GLN A1103
ILE A1159
ALA A1158
VAL A1175
 None
 1.18A 5n0sB-5ngyA:
undetectable		 5n0sB-5ngyA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 5 VAL A  43
SER A  37
PHE A 401
ALA A  23
VAL A  51
 None
 1.13A 5n0sB-5ns8A:
undetectable		 5n0sB-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 5 VAL A   7
VAL A   6
SER A 271
ALA A 507
VAL A 525
 None
 1.17A 5n0sB-5oc1A:
undetectable		 5n0sB-5oc1A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L44,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 ILE c 215
VAL c 169
VAL c 165
PHE c 195
GLN c 192
 None
 1.17A 5n0sB-5oolc:
undetectable		 5n0sB-5oolc:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		5 ILE A 398
VAL A 269
PHE A 271
ILE A 392
ALA A 393
 None
 1.18A 5n0sB-5u6sA:
undetectable		 5n0sB-5u6sA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		5 ILE A 385
VAL A 458
TYR A 397
ILE A 160
ALA A 161
 None
 1.02A 5n0sB-5uj6A:
undetectable		 5n0sB-5uj6A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve6 TYROSINE-PROTEIN
KINASE SGK223

(Homo sapiens) 		no annotation 5 ILE A1318
HIS A1143
PHE A1252
ILE A1316
ALA A1321
 None
 1.13A 5n0sB-5ve6A:
undetectable		 5n0sB-5ve6A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		5 ILE A 290
VAL A 297
SER A 292
ALA A 176
VAL A 179
 None
 1.17A 5n0sB-5xfaA:
undetectable		 5n0sB-5xfaA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys9 ACYL-COENZYME A
OXIDASE 3

(Yarrowia
lipolytica) 		no annotation 5 ILE A 264
PHE A 160
VAL A 124
ILE A 189
VAL A 231
 None
FAD  A 801 (-4.9A)
None
None
None
 1.16A 5n0sB-5ys9A:
undetectable		 5n0sB-5ys9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24

(Saccharomyces
cerevisiae) 		no annotation 5 HIS A  69
VAL A  72
ILE A  97
ALA A  93
VAL A 111
 None
 1.14A 5n0sB-6asoA:
undetectable		 5n0sB-6asoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2

(Mycobacterium
tuberculosis) 		no annotation 5 ILE A 188
VAL A 297
ILE A 211
ALA A 212
VAL A  97
 None
 1.05A 5n0sB-6ayvA:
3.6		 5n0sB-6ayvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0t FASCIN

(Homo sapiens) 		no annotation 5 PHE A 122
SER A 120
GLN A 124
ALA A 129
VAL A 126
 None
 1.16A 5n0sB-6b0tA:
undetectable		 5n0sB-6b0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egt GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		no annotation 5 ILE A1052
VAL A 726
SER A1075
TYR A1099
ALA A1031
 None
 1.15A 5n0sB-6egtA:
undetectable		 5n0sB-6egtA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 6 ILE A 339
HIS A 315
VAL A 355
GLN A 362
ILE A 191
ALA A 192
 None
 1.31A 5n0sB-6f5dA:
2.0		 5n0sB-6f5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 GLY A 192
ALA A 190
MET A 109
THR A 158
 None
 1.22A 5n0sB-1brwA:
0.5		 5n0sB-1brwA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))

(Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10) 		4 GLY L 123
ALA L 113
MET L 391
THR L 260
 None
None
CYS  L 432 (-3.7A)
None
 1.34A 5n0sB-1hfeL:
0.8		 5n0sB-1hfeL:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htp H-PROTEIN

(Pisum sativum) 		PF01597
(GCV_H) 		4 GLY A  55
ALA A  58
MET A 100
THR A  65
 None
 1.46A 5n0sB-1htpA:
undetectable		 5n0sB-1htpA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		4 GLY A 475
ALA A 142
MET A  80
THR A  93
 None
 1.32A 5n0sB-1m7jA:
0.0		 5n0sB-1m7jA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE

(Enterobacter
cloacae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 419
ALA A 415
MET A 448
THR A 441
 None
 1.41A 5n0sB-1ovmA:
0.0		 5n0sB-1ovmA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1php 3-PHOSPHOGLYCERATE
KINASE

(Geobacillus
stearothermophilus) 		PF00162
(PGK) 		4 GLY A 372
ALA A 148
MET A 171
THR A 156
 None
 1.23A 5n0sB-1phpA:
1.5		 5n0sB-1phpA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		4 GLY A 173
ALA A 194
MET A 201
THR A 234
 None
 1.42A 5n0sB-1pz3A:
0.0		 5n0sB-1pz3A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpx PROTEIN
(TRANSALDOLASE (EC
2.2.1.2))

(Thermotoga
maritima) 		PF00923
(TAL_FSA) 		4 GLY A 131
ALA A 163
MET A 143
THR A 107
 None
 1.49A 5n0sB-1vpxA:
0.2		 5n0sB-1vpxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsj RIBONUCLEASE HI

(Escherichia
coli) 		PF00075
(RNase_H) 		4 GLY A  23
ALA A  37
MET A  47
THR A 145
 None
 1.43A 5n0sB-1wsjA:
0.0		 5n0sB-1wsjA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF01134
(GIDA) 		4 GLY A 122
ALA A 120
MET A  40
THR A  18
 FAD  A 301 (-3.2A)
None
None
None
 1.27A 5n0sB-2culA:
undetectable		 5n0sB-2culA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmu PUTATIVE
PYRIDOXAMINE
5-PHOSPHATE-DEPENDEN
T DEHYDRASE, WBDK

(Escherichia
coli) 		PF01041
(DegT_DnrJ_EryC1) 		4 GLY A 195
ALA A 191
MET A 164
THR A  10
 None
 1.29A 5n0sB-2gmuA:
undetectable		 5n0sB-2gmuA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imh HYPOTHETICAL PROTEIN
UNP Q5LQD5_SILPO

(Ruegeria
pomeroyi) 		PF06267
(DUF1028) 		4 GLY A  17
ALA A  19
MET A 129
THR A   2
 None
 1.23A 5n0sB-2imhA:
undetectable		 5n0sB-2imhA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imh HYPOTHETICAL PROTEIN
UNP Q5LQD5_SILPO

(Ruegeria
pomeroyi) 		PF06267
(DUF1028) 		4 GLY A  17
ALA A  19
MET A 129
THR A  21
 None
 1.23A 5n0sB-2imhA:
undetectable		 5n0sB-2imhA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvd FERREDOXIN-THIOREDOX
IN REDUCTASE,
CATALYTIC CHAIN

(Synechocystis
sp.) 		PF02943
(FeThRed_B) 		4 GLY A  42
ALA A  37
MET A 116
THR A 108
 None
 1.30A 5n0sB-2pvdA:
undetectable		 5n0sB-2pvdA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 GLY A 137
ALA A 510
MET A  48
THR A 148
 None
 1.14A 5n0sB-2yikA:
undetectable		 5n0sB-2yikA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2k TRNA(ILE)-LYSIDINE
SYNTHASE

(Geobacillus
kaustophilus) 		PF01171
(ATP_bind_3)
PF09179
(TilS)
PF11734
(TilS_C) 		4 GLY A 333
ALA A 330
MET A 418
THR A 327
 None
 1.47A 5n0sB-3a2kA:
2.4		 5n0sB-3a2kA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5p PROTEIN BAS0735 OF
UNKNOWN FUNCTION

(Bacillus
anthracis) 		PF11579
(DUF3238) 		4 GLY A  89
ALA A  91
MET A  47
THR A  93
 None
 1.49A 5n0sB-3c5pA:
undetectable		 5n0sB-3c5pA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 307
ALA A  16
MET A 314
THR A  30
 None
 1.36A 5n0sB-3cgdA:
undetectable		 5n0sB-3cgdA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5q PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Staphylococcus
aureus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 GLY A 192
ALA A 190
MET A 109
THR A 158
 None
 1.46A 5n0sB-3h5qA:
undetectable		 5n0sB-3h5qA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE

(Bacillus
subtilis) 		PF01593
(Amino_oxidase) 		4 GLY A  57
ALA A 356
MET A 403
THR A 348
 None
 1.16A 5n0sB-3i6dA:
undetectable		 5n0sB-3i6dA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Streptococcus
pyogenes) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLY A 208
ALA A 206
MET A 186
THR A 169
 None
 1.40A 5n0sB-3lgxA:
undetectable		 5n0sB-3lgxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Toxoplasma
gondii) 		PF01048
(PNP_UDP_1) 		4 GLY A  28
ALA A  94
MET A 189
THR A 239
 PO4  A 281 (-3.2A)
None
None
None
 1.49A 5n0sB-3mb8A:
1.8		 5n0sB-3mb8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nn2 CHLORITE DISMUTASE

(Nitrospira
defluvii) 		PF06778
(Chlor_dismutase) 		4 GLY A  98
ALA A  17
MET A  87
THR A  15
 None
 1.41A 5n0sB-3nn2A:
undetectable		 5n0sB-3nn2A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 GLY A 511
ALA A 195
MET A 459
THR A 357
 None
 0.99A 5n0sB-3p4sA:
undetectable		 5n0sB-3p4sA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubg NEURAL-CADHERIN

(Drosophila
melanogaster) 		PF00028
(Cadherin) 		4 GLY A 598
ALA A 569
MET A 550
THR A 635
 None
 1.45A 5n0sB-3ubgA:
undetectable		 5n0sB-3ubgA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uma HYPOTHETICAL
PEROXIREDOXIN
PROTEIN

(Sinorhizobium
meliloti) 		PF08534
(Redoxin) 		4 GLY A   6
ALA A   4
MET A 130
THR A   2
 None
 1.23A 5n0sB-3umaA:
undetectable		 5n0sB-3umaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwd PHOSPHOGLYCERATE
KINASE

(Bacillus
anthracis) 		PF00162
(PGK) 		4 GLY A 372
ALA A 148
MET A 171
THR A 156
 None
 1.33A 5n0sB-3uwdA:
2.0		 5n0sB-3uwdA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Thermococcus
kodakarensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 GLY A 297
ALA A 290
MET A 277
THR A 210
 None
 1.17A 5n0sB-3wjpA:
undetectable		 5n0sB-3wjpA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c76 FMN REDUCTASE
(NADPH)

(Pseudomonas
putida) 		PF03358
(FMN_red) 		4 GLY A 145
ALA A 114
MET A 125
THR A  21
 PGE  A 206 (-4.7A)
None
None
None
 1.43A 5n0sB-4c76A:
undetectable		 5n0sB-4c76A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 GLY A 193
ALA A 111
MET A 105
THR A 248
 ALF  A1001 (-3.1A)
GDP  A1003 (-4.1A)
None
GDP  A1003 ( 4.4A)
 1.49A 5n0sB-4c7oA:
5.6		 5n0sB-4c7oA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezb UNCHARACTERIZED
CONSERVED PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		4 GLY A  21
ALA A  25
MET A 156
THR A   2
 None
 1.36A 5n0sB-4ezbA:
undetectable		 5n0sB-4ezbA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		4 GLY A 109
ALA A 330
MET A 294
THR A 285
 None
 1.09A 5n0sB-4hxyA:
undetectable		 5n0sB-4hxyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyv PYRUVATE KINASE 1

(Trypanosoma
brucei) 		PF00224
(PK)
PF02887
(PK_C) 		4 GLY A  80
ALA A  49
MET A  42
THR A  64
 None
 1.21A 5n0sB-4hyvA:
undetectable		 5n0sB-4hyvA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5i TRANSCRIPTIONAL
REGULATOR LSRR

(Escherichia
coli) 		PF04198
(Sugar-bind) 		4 GLY A 281
ALA A 283
MET A 296
THR A 310
 None
 1.23A 5n0sB-4l5iA:
undetectable		 5n0sB-4l5iA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 GLY A 291
ALA A 325
MET A 340
THR A 367
 None
 1.00A 5n0sB-4lihA:
undetectable		 5n0sB-4lihA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 GLY A 197
ALA A 195
MET A 192
THR A 354
 None
 1.38A 5n0sB-4lq1A:
undetectable		 5n0sB-4lq1A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okr MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		4 GLY A 217
ALA A 247
MET A 186
THR A 254
 None
 1.10A 5n0sB-4okrA:
undetectable		 5n0sB-4okrA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou4 ALPHA/BETA HYDROLASE
FOLD-3 DOMAIN
PROTEIN

(Pseudomonas sp.
ECU1011) 		PF07859
(Abhydrolase_3) 		4 GLY A 143
ALA A 140
MET A  82
THR A 177
 None
 1.28A 5n0sB-4ou4A:
undetectable		 5n0sB-4ou4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0c ABGT PUTATIVE
TRANSPORTER FAMILY

(Alcanivorax
borkumensis) 		PF03806
(ABG_transport) 		4 GLY A  84
ALA A  81
MET A 341
THR A 188
 None
 1.00A 5n0sB-4r0cA:
undetectable		 5n0sB-4r0cA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf7 CARBOHYDRATE/PYRIMID
INE KINASE, PFKB
FAMILY

(Thermococcus
kodakarensis) 		no annotation 4 GLY A 227
ALA A 224
MET A 258
THR A 245
 None
None
None
ACP  A 302 (-3.8A)
 1.49A 5n0sB-4xf7A:
undetectable		 5n0sB-4xf7A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2w HYPOTHETICAL (DI
HEME) PROTEIN

(Candidatus
Kuenenia
stuttgartiensis) 		PF00034
(Cytochrom_C) 		4 GLY C 197
ALA C 352
MET C 234
THR C 208
 None
 1.31A 5n0sB-5c2wC:
undetectable		 5n0sB-5c2wC:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8y SULFITE REDUCTASE
[FERREDOXIN],
CHLOROPLASTIC

(Zea mays) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLY A 553
ALA A 576
MET A 319
THR A 574
 None
 1.05A 5n0sB-5h8yA:
undetectable		 5n0sB-5h8yA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrm HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 4 GLY A 473
ALA A 494
MET A 543
THR A 539
 None
 1.19A 5n0sB-5hrmA:
undetectable		 5n0sB-5hrmA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioj HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 4 GLY A 473
ALA A 494
MET A 543
THR A 539
 None
 1.24A 5n0sB-5iojA:
undetectable		 5n0sB-5iojA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsq AMINOPEPTIDASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00883
(Peptidase_M17) 		4 GLY A 314
ALA A 497
MET A 309
THR A 403
 None
 1.50A 5n0sB-5nsqA:
undetectable		 5n0sB-5nsqA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veh KYNURENINE
AMINOTRANSFERASE

(Aedes aegypti) 		no annotation 4 GLY A 120
ALA A 116
MET A 141
THR A 107
 None
 1.37A 5n0sB-5vehA:
1.5		 5n0sB-5vehA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
SMALL SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 4 GLY A  72
ALA A  70
MET A  18
THR A  65
 None
 1.47A 5n0sB-5y6qA:
undetectable		 5n0sB-5y6qA:
undetectable