SIMILAR PATTERNS OF AMINO ACIDS FOR 5N0S_A_SAMA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 GLY A 170
HIS A 244
ILE A 431
ALA A 430
VAL A 379
 FAD  A 600 (-4.3A)
None
None
HEM  A 601 ( 3.8A)
None
 1.07A 5n0sA-1d4eA:
0.0		 5n0sA-1d4eA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f59 IMPORTIN BETA-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 ILE A 157
VAL A 134
VAL A 137
ILE A 116
ALA A 117
 None
 0.92A 5n0sA-1f59A:
0.0		 5n0sA-1f59A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A 253
GLY A 255
PHE A 449
TYR A 163
ALA A 200
 None
 1.10A 5n0sA-1g8xA:
0.1		 5n0sA-1g8xA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		5 ILE A  57
VAL A 262
VAL A 282
ILE A  12
VAL A  20
 None
 1.06A 5n0sA-1gynA:
undetectable		 5n0sA-1gynA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		5 ILE A 402
GLY A 403
HIS A 405
VAL A 466
ALA A 445
 None
None
None
None
TTP  A1589 (-4.8A)
 0.99A 5n0sA-1h79A:
2.3		 5n0sA-1h79A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ILE A 264
GLY A 266
PHE A 460
TYR A 174
ALA A 211
 None
 1.05A 5n0sA-1jx2A:
0.1		 5n0sA-1jx2A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF00215
(OMPdecase) 		5 HIS A 128
TYR A 206
ILE A 205
ALA A 203
VAL A 201
 None
None
None
UP6  A5001 (-3.3A)
UP6  A5001 ( 4.5A)
 1.10A 5n0sA-1losA:
undetectable		 5n0sA-1losA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0u GST2 GENE PRODUCT

(Drosophila
melanogaster) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ILE A 205
GLY A 204
VAL A 228
VAL A 231
VAL A 138
 None
 1.11A 5n0sA-1m0uA:
undetectable		 5n0sA-1m0uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE

(Homo sapiens) 		PF01182
(Glucosamine_iso) 		5 ILE A 203
GLY A 137
VAL A 135
VAL A 199
ILE A   5
 None
AGP  A2298 (-3.8A)
None
None
None
 1.11A 5n0sA-1ne7A:
undetectable		 5n0sA-1ne7A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onf GLUTATHIONE
REDUCTASE

(Plasmodium
falciparum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 461
PHE A 464
PHE A 491
ILE A 411
VAL A 439
 None
 1.11A 5n0sA-1onfA:
undetectable		 5n0sA-1onfA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 ILE A 157
VAL A 134
VAL A 137
ILE A 116
ALA A 117
 None
 0.91A 5n0sA-1qgrA:
undetectable		 5n0sA-1qgrA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qz9 KYNURENINASE

(Pseudomonas
fluorescens) 		PF00266
(Aminotran_5) 		6 ILE A 398
GLY A 396
VAL A 321
PHE A 317
ILE A 360
ALA A 358
 None
 1.45A 5n0sA-1qz9A:
1.7		 5n0sA-1qz9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7g NAD-DEPENDENT
DEACETYLASE 2

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		5 VAL A 189
PHE A  21
VAL A  20
ILE A  32
ALA A  28
 None
None
None
1PE  A 504 ( 4.7A)
NAD  A 703 ( 3.7A)
 0.91A 5n0sA-1s7gA:
undetectable		 5n0sA-1s7gA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		6 GLY A 322
HIS A 318
VAL A 317
ILE A 286
MET A 328
VAL A 290
 None
NH3  A 401 ( 3.9A)
None
None
None
None
 1.48A 5n0sA-1u7gA:
undetectable		 5n0sA-1u7gA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE

(Thermus
thermophilus) 		PF00697
(PRAI) 		5 ILE A 150
VAL A  56
VAL A  54
ILE A 155
ALA A 152
 None
 1.06A 5n0sA-1v5xA:
undetectable		 5n0sA-1v5xA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkb LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 GLY A 237
VAL A 412
TYR A 401
ILE A 400
ALA A 329
 None
None
SO4  A 907 (-4.7A)
None
None
 0.98A 5n0sA-1wkbA:
undetectable		 5n0sA-1wkbA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE

(Bos taurus) 		PF00587
(tRNA-synt_2b) 		5 ILE A 197
GLY A 216
ILE A 191
ALA A 192
VAL A 458
 None
 1.02A 5n0sA-1wleA:
undetectable		 5n0sA-1wleA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Borreliella
burgdorferi) 		PF02127
(Peptidase_M18) 		5 ILE A  85
PHE A 310
ALA A 325
MET A  89
VAL A 305
 None
 1.08A 5n0sA-1y7eA:
undetectable		 5n0sA-1y7eA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkd DUF185

(Rhodopseudomonas
palustris) 		PF02636
(Methyltransf_28) 		5 ILE A  87
HIS A 140
VAL A 146
ILE A 240
ALA A 155
 None
 0.94A 5n0sA-1zkdA:
undetectable		 5n0sA-1zkdA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		5 ILE A 182
HIS A 143
PHE A  93
VAL A  95
ALA A 208
 None
None
EDO  A 404 ( 4.6A)
None
None
 1.05A 5n0sA-2ashA:
undetectable		 5n0sA-2ashA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 ILE A 566
GLY A 427
HIS A 426
VAL A 527
VAL A 531
 None
 0.97A 5n0sA-2b3xA:
undetectable		 5n0sA-2b3xA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bws XAA-PRO
AMINOPEPTIDASE P

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 ILE A 215
GLY A 213
HIS A 210
ILE A 272
ALA A 261
 None
 1.10A 5n0sA-2bwsA:
undetectable		 5n0sA-2bwsA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5q RRAA-LIKE PROTEIN
YER010C

(Saccharomyces
cerevisiae) 		PF03737
(RraA-like) 		5 ILE A 169
PHE A  54
ILE A  75
ALA A  49
VAL A 116
 CME  A 170 ( 3.9A)
None
None
CME  A 170 ( 3.7A)
None
 1.03A 5n0sA-2c5qA:
undetectable		 5n0sA-2c5qA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Sulfurisphaera
tokodaii) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		5 ILE A 329
GLY A 356
VAL A 339
VAL A 341
VAL A 389
 None
 1.11A 5n0sA-2ggqA:
undetectable		 5n0sA-2ggqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7n PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE-LIKE 1

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 GLY A  65
PHE A  39
TYR A  78
ILE A  77
ALA A  75
 None
 0.99A 5n0sA-2k7nA:
undetectable		 5n0sA-2k7nA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n57 ACYL CARRIER PROTEIN

(Brucella
melitensis) 		PF00550
(PP-binding) 		5 ILE A  63
VAL A   8
VAL A  12
ALA A  59
VAL A  41
 None
 1.09A 5n0sA-2n57A:
undetectable		 5n0sA-2n57A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq9 ENDONUCLEASE 4

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		5 ILE A 126
GLY A 111
HIS A 109
PHE A  91
ALA A 127
 None
None
ZN  A 401 (-3.2A)
None
None
 1.02A 5n0sA-2nq9A:
undetectable		 5n0sA-2nq9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 ILE A  10
GLY A  90
VAL A 184
ALA A  29
VAL A 242
 None
 1.05A 5n0sA-2ntjA:
2.2		 5n0sA-2ntjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 ILE A 181
GLY A 206
ILE A 189
ALA A 185
VAL A 169
 None
 1.07A 5n0sA-2p50A:
undetectable		 5n0sA-2p50A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qps ALPHA-AMYLASE TYPE A
ISOZYME

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		5 ILE A 368
VAL A 385
PHE A 390
ILE A 342
VAL A 401
 None
 1.03A 5n0sA-2qpsA:
undetectable		 5n0sA-2qpsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3u PROTEASE DEGS

(Escherichia
coli) 		PF13365
(Trypsin_2) 		6 ILE A 215
GLY A 203
VAL A  59
VAL A  61
ILE A 244
ALA A 241
 None
 1.23A 5n0sA-2r3uA:
undetectable		 5n0sA-2r3uA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8w AGR_C_1641P

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		5 ILE A 289
PHE A 273
ILE A 295
ALA A 293
VAL A 318
 None
 1.07A 5n0sA-2r8wA:
undetectable		 5n0sA-2r8wA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uur COLLAGEN ALPHA-1(IX)
CHAIN

(Homo sapiens) 		no annotation 5 ILE A 121
PHE A 172
VAL A 173
TYR A  88
ILE A 217
 None
 0.87A 5n0sA-2uurA:
undetectable		 5n0sA-2uurA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wcq TNF-ALPHA INDUCER
PROTEIN

(Helicobacter
pylori) 		PF16753
(Tipalpha) 		5 GLY A 155
HIS A 157
VAL A 166
VAL A 170
ILE A 111
 None
 0.93A 5n0sA-2wcqA:
undetectable		 5n0sA-2wcqA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		5 GLY A 345
HIS A 347
VAL A 303
ILE A  51
ALA A  52
 None
ZN  A1476 ( 3.1A)
None
None
None
 1.09A 5n0sA-2x98A:
2.4		 5n0sA-2x98A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn1 LGPCA THIOREDOXIN

(synthetic
construct) 		PF00085
(Thioredoxin) 		5 ILE A   3
VAL A  57
PHE A  26
ILE A  44
ALA A  45
 None
 1.08A 5n0sA-2yn1A:
undetectable		 5n0sA-2yn1A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		5 GLY B 287
VAL B 341
TYR B 328
ALA B 296
VAL B 283
 None
 1.06A 5n0sA-3aeqB:
undetectable		 5n0sA-3aeqB:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		5 ILE A 174
VAL A 242
VAL A 234
ALA A 183
VAL A 246
 None
 1.04A 5n0sA-3auoA:
undetectable		 5n0sA-3auoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci2 CHYMOTRYPSIN
INHIBITOR 2

(Hordeum vulgare) 		PF00280
(potato_inhibit) 		5 ILE A  39
VAL A  70
PHE A  69
ALA A  46
VAL A  82
 None
 1.02A 5n0sA-3ci2A:
undetectable		 5n0sA-3ci2A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3co8 ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 223
VAL A 225
VAL A 229
ILE A  53
ALA A  54
 PLP  A 401 (-3.6A)
None
None
None
None
 1.06A 5n0sA-3co8A:
undetectable		 5n0sA-3co8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cz5 TWO-COMPONENT
RESPONSE REGULATOR,
LUXR FAMILY

(Aurantimonas
manganoxydans) 		PF00072
(Response_reg) 		5 ILE A 122
GLY A 104
VAL A 106
PHE A  85
TYR A  31
 None
 1.00A 5n0sA-3cz5A:
undetectable		 5n0sA-3cz5A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fip OUTER MEMBRANE USHER
PROTEIN PAPC

(Escherichia
coli) 		PF00577
(Usher) 		5 GLY A 360
VAL A 341
PHE A 357
TYR A 382
ALA A 384
 None
 1.06A 5n0sA-3fipA:
undetectable		 5n0sA-3fipA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb0 PEPTIDASE T

(Bacillus cereus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A 186
PHE A 246
VAL A 182
ILE A 204
ALA A 203
 None
 1.10A 5n0sA-3gb0A:
undetectable		 5n0sA-3gb0A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gio PUTATIVE
UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		PF16753
(Tipalpha) 		5 GLY A 155
HIS A 157
VAL A 166
VAL A 170
ILE A 111
 None
 1.01A 5n0sA-3gioA:
undetectable		 5n0sA-3gioA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR
COBRA VENOM FACTOR

(Naja kaouthia;
Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep) 		5 ILE B 941
TYR C1268
ILE C1255
MET C1301
VAL C1291
 None
 0.96A 5n0sA-3hs0B:
undetectable		 5n0sA-3hs0B:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00202
(Aminotran_3) 		5 GLY A 298
VAL A 260
PHE A 264
ILE A  72
ALA A 335
 None
PLP  A 474 (-4.1A)
None
None
None
 1.02A 5n0sA-3i5tA:
1.7		 5n0sA-3i5tA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum) 		PF00291
(PALP) 		5 ILE A 222
GLY A 219
VAL A 276
VAL A 273
ILE A 239
 None
LLP  A  91 ( 3.5A)
None
None
None
 0.86A 5n0sA-3iauA:
undetectable		 5n0sA-3iauA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum) 		PF00291
(PALP) 		5 ILE A 222
GLY A 219
VAL A 276
VAL A 273
VAL A 241
 None
LLP  A  91 ( 3.5A)
None
None
None
 0.85A 5n0sA-3iauA:
undetectable		 5n0sA-3iauA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		5 ILE A  65
GLY A  10
PHE A 198
ALA A  64
VAL A 112
 None
None
ACT  A 500 (-4.8A)
None
None
 1.06A 5n0sA-3im8A:
undetectable		 5n0sA-3im8A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		5 ILE A 262
GLY A 264
PHE A 460
TYR A 161
ALA A 198
 None
 1.07A 5n0sA-3j04A:
undetectable		 5n0sA-3j04A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9q SHEATH

(Pseudomonas
aeruginosa) 		PF04984
(Phage_sheath_1)
PF17482
(Phage_sheath_1C) 		5 ILE A  99
GLY A 100
VAL A  85
VAL A  83
ALA A 138
 None
 1.04A 5n0sA-3j9qA:
undetectable		 5n0sA-3j9qA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsa HOMOSERINE
DEHYDROGENASE

(Thermoplasma
volcanium) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 ILE A   8
GLY A  10
PHE A 103
ILE A  86
VAL A 115
 None
NAD  A 501 (-3.4A)
None
None
None
 1.02A 5n0sA-3jsaA:
undetectable		 5n0sA-3jsaA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5o UNCHARACTERIZED
PROTEIN FROM DUF364
FAMILY

(Desulfitobacterium
hafniense) 		PF04016
(DUF364)
PF13938
(DUF4213) 		5 GLY A 129
HIS A 130
PHE A 113
ILE A 196
VAL A 171
 CL  A 301 ( 3.9A)
None
EDO  A 311 ( 4.8A)
None
None
 1.04A 5n0sA-3l5oA:
2.4		 5n0sA-3l5oA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgi PROTEASE DEGS

(Escherichia
coli) 		PF13365
(Trypsin_2) 		6 ILE A 215
GLY A 202
VAL A  59
VAL A  61
ILE A 244
ALA A 241
 None
 1.47A 5n0sA-3lgiA:
undetectable		 5n0sA-3lgiA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgi PROTEASE DEGS

(Escherichia
coli) 		PF13365
(Trypsin_2) 		6 ILE A 215
GLY A 203
VAL A  59
VAL A  61
ILE A 244
ALA A 241
 None
 1.26A 5n0sA-3lgiA:
undetectable		 5n0sA-3lgiA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toe DNA/RNA-BINDING
PROTEIN ALBA

(Methanothermobacter
thermautotrophicus) 		PF01918
(Alba) 		5 ILE A   9
VAL A   6
VAL A  32
ILE A  41
ALA A  40
 None
 1.05A 5n0sA-3toeA:
2.8		 5n0sA-3toeA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uuf LIP1, SECRETORY
LIPASE (FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		5 GLY A 173
HIS A 170
VAL A  52
ILE A 184
ALA A 181
 None
 1.04A 5n0sA-3uufA:
undetectable		 5n0sA-3uufA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqo UNCHARACTERIZED
PROTEIN MJ1311

(Methanocaldococcus
jannaschii) 		PF01261
(AP_endonuc_2) 		5 ILE A 156
GLY A 157
HIS A 218
ILE A 148
ALA A 149
 None
 0.92A 5n0sA-3wqoA:
undetectable		 5n0sA-3wqoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a63 APOPTOSIS
STIMULATING OF P53
PROTEIN 2

(Homo sapiens) 		PF00018
(SH3_1)
PF12796
(Ank_2) 		5 ILE B1062
GLY B1115
VAL B1018
MET B1084
VAL B1109
 None
 0.97A 5n0sA-4a63B:
undetectable		 5n0sA-4a63B:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ade SUCCINYLORNITHINE
TRANSAMINASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		6 GLY A 334
PHE A 315
VAL A 316
ILE A 367
ALA A 368
VAL A 373
 None
 1.27A 5n0sA-4adeA:
undetectable		 5n0sA-4adeA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 5 ILE A  49
GLY A 492
HIS A 494
VAL A 320
ALA A  44
 None
 1.01A 5n0sA-4bb9A:
2.1		 5n0sA-4bb9A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A

(Homo sapiens) 		PF00995
(Sec1) 		5 ILE A  80
VAL A  83
PHE A 113
VAL A 114
ILE A 135
 None
 1.09A 5n0sA-4bx9A:
undetectable		 5n0sA-4bx9A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccw CARBOXYL ESTERASE NP

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		5 ILE A 152
GLY A 133
HIS A 135
PHE A 225
ILE A 264
 None
 0.89A 5n0sA-4ccwA:
undetectable		 5n0sA-4ccwA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuk D-LACTATE
DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		6 ILE A 238
GLY A 235
VAL A 259
PHE A 292
ILE A 252
ALA A 243
 None
 1.17A 5n0sA-4cukA:
undetectable		 5n0sA-4cukA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egf L-XYLULOSE REDUCTASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 GLY A 189
HIS A 188
VAL A 141
ILE A 150
VAL A  97
 None
 1.00A 5n0sA-4egfA:
2.4		 5n0sA-4egfA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi2 CROTONYL-COA
CARBOXYLASE/REDUCTAS
E

(Methylobacterium
extorquens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 218
VAL A 225
PHE A 226
VAL A 228
ALA A 332
 NAP  A 502 (-3.4A)
None
None
None
NAP  A 502 (-3.6A)
 1.11A 5n0sA-4gi2A:
3.3		 5n0sA-4gi2A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		5 ILE A  10
GLY A  87
VAL A 179
ALA A  27
VAL A 230
 None
 1.05A 5n0sA-4ituA:
undetectable		 5n0sA-4ituA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 5 ILE A  49
GLY A 492
HIS A 494
VAL A 320
ALA A  44
 None
 1.02A 5n0sA-4lc9A:
2.1		 5n0sA-4lc9A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 0.99A 5n0sA-4o7dA:
undetectable		 5n0sA-4o7dA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4piv FATTY ACID SYNTHASE

(Homo sapiens) 		PF08242
(Methyltransf_12)
PF08659
(KR) 		5 ILE A1946
VAL A2018
PHE A2016
ILE A1956
ALA A1952
 None
 1.01A 5n0sA-4pivA:
2.2		 5n0sA-4pivA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Mycolicibacterium
smegmatis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 ILE A 531
GLY A 484
ILE A 246
MET A 233
VAL A 250
 None
 1.02A 5n0sA-4rmfA:
undetectable		 5n0sA-4rmfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA

(Escherichia
coli) 		PF03611
(EIIC-GAT) 		5 ILE A 367
GLY A 368
ILE A 415
ALA A 411
MET A 387
 None
 1.08A 5n0sA-4rp8A:
undetectable		 5n0sA-4rp8A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rph UDP-GALACTOPYRANOSE
MUTASE

(Mycobacterium
tuberculosis) 		no annotation 5 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.90A 5n0sA-4rphB:
undetectable		 5n0sA-4rphB:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 ILE A 358
GLY A 391
VAL A 397
PHE A 350
ALA A 357
 None
 0.99A 5n0sA-4umvA:
2.4		 5n0sA-4umvA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 ILE A 358
GLY A 391
VAL A 397
PHE A 350
MET A 359
 None
 1.04A 5n0sA-4umvA:
2.4		 5n0sA-4umvA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 5 ILE A 248
GLY A 247
VAL A 375
ILE A 281
ALA A 282
 None
 0.92A 5n0sA-4wseA:
undetectable		 5n0sA-4wseA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk6 QUINOLINATE SYNTHASE
A

(Pyrococcus
horikoshii) 		PF02445
(NadA) 		5 VAL A 164
ILE A 292
ALA A 291
MET A 295
VAL A 110
 None
 1.10A 5n0sA-4zk6A:
2.5		 5n0sA-4zk6A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		5 GLY A 193
HIS A 192
TYR A 125
ILE A 118
ALA A 119
 None
MN  A 601 ( 3.3A)
None
None
None
 0.87A 5n0sA-5a29A:
undetectable		 5n0sA-5a29A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1m MU-TYPE OPIOID
RECEPTOR

(Mus musculus) 		PF00001
(7tm_1) 		5 GLY A 253
VAL A 282
VAL A 286
ILE A 167
VAL A 163
 None
None
None
None
P6G  A 406 ( 4.7A)
 1.02A 5n0sA-5c1mA:
undetectable		 5n0sA-5c1mA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 ILE A 493
GLY A 519
HIS A 521
PHE A 473
ALA A 485
 None
 0.99A 5n0sA-5d3oA:
undetectable		 5n0sA-5d3oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		5 ILE A 587
GLY A 627
VAL A 625
PHE A 571
ALA A 591
 None
 1.03A 5n0sA-5e7pA:
undetectable		 5n0sA-5e7pA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans) 		PF01580
(FtsK_SpoIIIE) 		5 ILE A1282
HIS A1279
VAL A1408
PHE A1374
VAL A1373
 None
 1.09A 5n0sA-5fv0A:
undetectable		 5n0sA-5fv0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A 276
GLY A 278
PHE A 473
TYR A 182
ALA A 219
 None
 1.10A 5n0sA-5i4eA:
1.8		 5n0sA-5i4eA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8s AMINO ACYL PEPTIDASE

(Sporosarcina
psychrophila) 		PF00326
(Peptidase_S9) 		5 ILE A 292
GLY A 307
HIS A 314
VAL A 312
ILE A 271
 None
 1.01A 5n0sA-5l8sA:
undetectable		 5n0sA-5l8sA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mso CARBOXYLIC ACID
REDUCTASE

(Mycobacterium
marinum) 		PF07993
(NAD_binding_4) 		5 ILE A1006
VAL A1156
ILE A1085
ALA A1010
VAL A1075
 None
 0.92A 5n0sA-5msoA:
undetectable		 5n0sA-5msoA:
17.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n0o PEPTIDE
N-METHYLTRANSFERASE

(Omphalotus
olearius) 		no annotation 6 ILE A  19
GLY A  18
TYR A 211
ILE A 212
ALA A 213
VAL A 243
 SAM  A 501 (-4.5A)
None
SAM  A 501 (-4.7A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.0A)
 0.81A 5n0sA-5n0oA:
43.8		 5n0sA-5n0oA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n0o PEPTIDE
N-METHYLTRANSFERASE

(Omphalotus
olearius) 		no annotation 11 ILE A  19
GLY A  99
HIS A 100
VAL A 103
PHE A 104
VAL A 105
PHE A 171
TYR A 211
ILE A 212
ALA A 213
VAL A 243
 SAM  A 501 (-4.5A)
SAM  A 501 (-3.5A)
None
SAM  A 501 (-4.4A)
None
None
SAM  A 501 (-4.3A)
SAM  A 501 (-4.7A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.0A)
 0.17A 5n0sA-5n0oA:
43.8		 5n0sA-5n0oA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n0o PEPTIDE
N-METHYLTRANSFERASE

(Omphalotus
olearius) 		no annotation 5 ILE A  19
GLY A  99
HIS A 100
VAL A 105
MET A 215
 SAM  A 501 (-4.5A)
SAM  A 501 (-3.5A)
None
None
None
 0.85A 5n0sA-5n0oA:
43.8		 5n0sA-5n0oA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oji DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Caenorhabditis
elegans) 		no annotation 5 GLY A  23
VAL A  93
ILE A  51
ALA A  50
VAL A  62
 None
 1.08A 5n0sA-5ojiA:
2.1		 5n0sA-5ojiA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgf UNCHARACTERIZED
PROTEIN

(Bacteroides
dorei) 		PF00144
(Beta-lactamase) 		5 GLY A 201
VAL A 189
TYR A 210
ILE A 307
VAL A  54
 GOL  A 401 (-3.4A)
None
None
None
None
 1.07A 5n0sA-5tgfA:
undetectable		 5n0sA-5tgfA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tum TETRACYCLINE
DESTRUCTASE TET(56)

(Legionella
longbeachae) 		PF01494
(FAD_binding_3) 		5 ILE A  51
GLY A  50
VAL A  48
TYR A 310
ILE A 311
 None
 0.96A 5n0sA-5tumA:
undetectable		 5n0sA-5tumA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		5 ILE A 385
VAL A 458
TYR A 397
ILE A 160
ALA A 161
 None
 1.01A 5n0sA-5uj6A:
undetectable		 5n0sA-5uj6A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 GLY B 474
HIS B 473
VAL B 468
ALA B 509
VAL B 489
 None
 0.96A 5n0sA-5up2B:
2.2		 5n0sA-5up2B:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase)
PF12796
(Ank_2) 		5 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.02A 5n0sA-5uqeA:
undetectable		 5n0sA-5uqeA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vey HISTONE H2B TYPE
1-J,HISTONE H2A TYPE
1-B/E

(Homo sapiens) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		5 ILE A 167
GLY A 156
HIS A  25
ILE A  37
ALA A  34
 None
 1.08A 5n0sA-5veyA:
undetectable		 5n0sA-5veyA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w25 ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Mycobacterium
tuberculosis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 ILE A 534
GLY A 487
ILE A 249
MET A 236
VAL A 253
 None
 1.04A 5n0sA-5w25A:
undetectable		 5n0sA-5w25A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 5 GLY A 233
VAL A  89
PHE A  36
ILE A  42
ALA A  43
 None
 1.08A 5n0sA-5wugA:
undetectable		 5n0sA-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhb POLYHEDRIN

(Cypovirus 1) 		no annotation 5 GLY A 181
VAL A 117
VAL A  35
ILE A 109
VAL A  39
 None
 0.96A 5n0sA-5yhbA:
undetectable		 5n0sA-5yhbA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2

(Mycobacterium
tuberculosis) 		no annotation 5 ILE A 188
VAL A 297
ILE A 211
ALA A 212
VAL A  97
 None
 1.05A 5n0sA-6ayvA:
3.6		 5n0sA-6ayvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dde MU-TYPE OPIOID
RECEPTOR

(Mus musculus) 		no annotation 5 GLY R 253
VAL R 282
VAL R 286
ILE R 167
VAL R 163
 None
 0.96A 5n0sA-6ddeR:
undetectable		 5n0sA-6ddeR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crz TOLB PROTEIN

(Escherichia
coli) 		PF04052
(TolB_N)
PF07676
(PD40) 		4 SER A 183
ALA A 227
GLN A 314
THR A 270
 None
 1.35A 5n0sA-1crzA:
undetectable		 5n0sA-1crzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzs SOPE

(Salmonella
enterica) 		PF07487
(SopE_GEF) 		4 SER B  99
ALA B 100
GLN B 109
THR B 110
 None
 1.23A 5n0sA-1gzsB:
undetectable		 5n0sA-1gzsB:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibj CYSTATHIONINE
BETA-LYASE

(Arabidopsis
thaliana) 		PF01053
(Cys_Met_Meta_PP) 		4 SER A 162
ALA A 159
GLN A 306
THR A 155
 None
 1.19A 5n0sA-1ibjA:
0.0		 5n0sA-1ibjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npc NEUTRAL PROTEASE

(Bacillus cereus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 SER A 135
ALA A  74
GLN A 120
THR A  42
 None
 1.24A 5n0sA-1npcA:
0.0		 5n0sA-1npcA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 TRIMETHYLAMINE
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 SER A 158
ALA A 161
GLN A  41
THR A  90
 None
 1.27A 5n0sA-1o94A:
0.7		 5n0sA-1o94A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pe9 PECTATE LYASE A

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		4 SER A  11
ALA A  12
GLN A  20
THR A 197
 None
 1.37A 5n0sA-1pe9A:
undetectable		 5n0sA-1pe9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzx HYPOTHETICAL PROTEIN
APC36103

(Geobacillus
stearothermophilus) 		PF02645
(DegV) 		4 SER A 119
ALA A  86
GLN A  96
THR A  94
 None
 1.12A 5n0sA-1pzxA:
1.5		 5n0sA-1pzxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1n FERRIC-IRON BINDING
PROTEIN

(Neisseria
gonorrhoeae) 		PF01547
(SBP_bac_1) 		4 SER A 139
ALA A 141
GLN A  58
THR A 226
 CNB  A 400 ( 3.8A)
CNB  A 400 ( 4.7A)
None
None
 1.20A 5n0sA-1r1nA:
undetectable		 5n0sA-1r1nA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9c PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2

(Homo sapiens) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 SER A 223
ALA A 224
GLN A  92
THR A  59
 None
 1.27A 5n0sA-1s9cA:
0.2		 5n0sA-1s9cA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE

(Bacillus
subtilis) 		PF03102
(NeuB)
PF08666
(SAF) 		4 SER A 130
ALA A 129
GLN A  52
THR A 108
 None
 0.99A 5n0sA-1vliA:
undetectable		 5n0sA-1vliA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsv AMINOMETHYLTRANSFERA
SE

(Homo sapiens) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 SER A 235
ALA A 232
GLN A 155
THR A  44
 SER  A 235 ( 0.0A)
ALA  A 232 ( 0.0A)
GLN  A 155 ( 0.6A)
THR  A  44 ( 0.8A)
 1.44A 5n0sA-1wsvA:
undetectable		 5n0sA-1wsvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
brevis) 		PF13561
(adh_short_C2) 		4 SER A 168
ALA A 169
GLN A 126
THR A 121
 None
 1.31A 5n0sA-1zjyA:
1.8		 5n0sA-1zjyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f00 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 SER A 138
ALA A 135
GLN A 322
THR A 324
 None
 1.21A 5n0sA-2f00A:
2.1		 5n0sA-2f00A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Staphylococcus
aureus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 SER A 246
ALA A 247
GLN A  91
THR A  10
 None
 1.09A 5n0sA-2gqdA:
undetectable		 5n0sA-2gqdA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l5v PROTEASOMAL
UBIQUITIN RECEPTOR
ADRM1

(Homo sapiens) 		PF16550
(RPN13_C) 		4 SER A 290
ALA A 289
GLN A 337
THR A 332
 None
 1.48A 5n0sA-2l5vA:
undetectable		 5n0sA-2l5vA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2loz TENSIN-LIKE C1
DOMAIN-CONTAINING
PHOSPHATASE

(Homo sapiens) 		PF08416
(PTB) 		4 SER A1299
ALA A1298
GLN A1293
THR A1286
 None
 1.17A 5n0sA-2lozA:
undetectable		 5n0sA-2lozA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lqg TALIN-1

(Mus musculus) 		no annotation 4 SER A1007
ALA A1004
GLN A1019
THR A 931
 None
 1.28A 5n0sA-2lqgA:
undetectable		 5n0sA-2lqgA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvp UNCHARACTERIZED
PROTEIN

(Shewanella
amazonensis) 		PF04952
(AstE_AspA) 		4 SER A  78
ALA A  79
GLN A 249
THR A 245
 None
 1.42A 5n0sA-2qvpA:
1.4		 5n0sA-2qvpA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe5 OUTER MEMBRANE PORIN
C

(Escherichia
coli) 		PF00267
(Porin_1) 		4 SER A 180
ALA A 193
GLN A 122
THR A 101
 None
 1.47A 5n0sA-2xe5A:
undetectable		 5n0sA-2xe5A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN

(Prochlorococcus
marinus) 		PF00142
(Fer4_NifH) 		4 SER A  54
ALA A  51
GLN A 262
THR A 247
 None
 0.96A 5n0sA-2ynmA:
undetectable		 5n0sA-2ynmA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		4 SER A 282
ALA A 281
GLN A 217
THR A 231
 None
 1.44A 5n0sA-3a9gA:
undetectable		 5n0sA-3a9gA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 4 SER A 325
ALA A 324
GLN A  74
THR A  65
 None
 1.09A 5n0sA-3ahmA:
undetectable		 5n0sA-3ahmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bi3 ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB

(Escherichia
coli) 		PF13532
(2OG-FeII_Oxy_2) 		4 SER A  42
ALA A  41
GLN A  84
THR A  62
 None
 1.28A 5n0sA-3bi3A:
undetectable		 5n0sA-3bi3A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bop BETA-NEUREXIN 2D4

(Mus musculus) 		PF02210
(Laminin_G_2) 		4 SER A 125
ALA A 126
GLN A 227
THR A 121
 None
 1.43A 5n0sA-3bopA:
undetectable		 5n0sA-3bopA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB

(Sinorhizobium
meliloti) 		no annotation 4 SER A  70
ALA A  69
GLN A 304
THR A 293
 None
 1.08A 5n0sA-3e4pA:
undetectable		 5n0sA-3e4pA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieh PUTATIVE
METALLOPEPTIDASE

(Shewanella
baltica) 		PF04952
(AstE_AspA) 		4 SER A  79
ALA A  80
GLN A 250
THR A 246
 None
None
PGE  A 288 ( 3.5A)
None
 1.48A 5n0sA-3iehA:
1.5		 5n0sA-3iehA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 4 SER X 418
ALA X 393
GLN X 333
THR X 377
 None
 1.37A 5n0sA-3kvnX:
undetectable		 5n0sA-3kvnX:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwl UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 4 SER A 437
ALA A 435
GLN A 469
THR A 464
 None
 1.46A 5n0sA-3kwlA:
undetectable		 5n0sA-3kwlA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mw3 NEUREXIN-2-BETA

(Rattus
norvegicus) 		PF02210
(Laminin_G_2) 		4 SER A 125
ALA A 126
GLN A 257
THR A 121
 None
 1.41A 5n0sA-3mw3A:
undetectable		 5n0sA-3mw3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r77 PROBABLE
ISOCHORISMATASE

(Pseudomonas
fluorescens) 		PF00857
(Isochorismatase) 		4 SER A 126
ALA A 127
GLN A  78
THR A  76
 None
None
QLI  A 500 (-3.0A)
None
 1.45A 5n0sA-3r77A:
1.2		 5n0sA-3r77A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugg SUCROSE:(SUCROSE/FRU
CTAN)
6-FRUCTOSYLTRANSFERA
SE

(Pachysandra
terminalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 SER A 459
ALA A 458
GLN A  18
THR A 507
 None
 1.34A 5n0sA-3uggA:
undetectable		 5n0sA-3uggA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
HEME SUBUNIT

(Thermochromatium
tepidum) 		no annotation 4 SER A 172
ALA A 171
GLN A 124
THR A 126
 None
 1.28A 5n0sA-3vrdA:
undetectable		 5n0sA-3vrdA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiw GLYCOSYL HYDROLASE
FAMILY 88

(Pedobacter
heparinus) 		PF07470
(Glyco_hydro_88) 		4 SER A 314
ALA A 315
GLN A 322
THR A 256
 None
 1.38A 5n0sA-3wiwA:
undetectable		 5n0sA-3wiwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 SER A 127
ALA A  66
GLN A 112
THR A  37
 None
 1.24A 5n0sA-4b52A:
undetectable		 5n0sA-4b52A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 SER B2234
ALA B2235
GLN B2221
THR B2262
 None
 1.29A 5n0sA-4bedB:
undetectable		 5n0sA-4bedB:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxh ELONGATION FACTOR 1A

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 SER A 337
ALA A 338
GLN A 378
THR A 340
 G  Y  53 ( 2.3A)
None
None
U  Y  52 ( 4.3A)
 1.14A 5n0sA-4cxhA:
undetectable		 5n0sA-4cxhA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e54 DNA DAMAGE-BINDING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		4 SER B 409
ALA B 408
GLN B 105
THR B 406
 None
 1.42A 5n0sA-4e54B:
undetectable		 5n0sA-4e54B:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA

(Rhodococcus
rhodochrous) 		PF00067
(p450) 		4 SER A 240
ALA A 237
GLN A 251
THR A 384
 None
HEM  A 601 (-3.1A)
None
None
 1.27A 5n0sA-4ep6A:
undetectable		 5n0sA-4ep6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 SER C1016
ALA C1017
GLN C1038
THR C1031
 None
 1.42A 5n0sA-4hb4C:
undetectable		 5n0sA-4hb4C:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu8 GH10 XYLANASE

(Globitermes
brachycerastes) 		PF00331
(Glyco_hydro_10)
PF02368
(Big_2) 		4 SER A  59
ALA A  58
GLN A  31
THR A 105
 None
 1.25A 5n0sA-4hu8A:
undetectable		 5n0sA-4hu8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Yersinia pestis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 SER A 138
ALA A 135
GLN A 322
THR A 324
 None
 1.19A 5n0sA-4hv4A:
2.2		 5n0sA-4hv4A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN

(Ralstonia
solanacearum) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 SER A 110
ALA A 107
GLN A 159
THR A 157
 None
 1.08A 5n0sA-4kf9A:
undetectable		 5n0sA-4kf9A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9a ACYL-COA
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 SER A 324
ALA A 323
GLN A 318
THR A 299
 None
 1.40A 5n0sA-4m9aA:
undetectable		 5n0sA-4m9aA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mpt PUTATIVE
LEU/ILE/VAL-BINDING
PROTEIN

(Bordetella
pertussis) 		PF13458
(Peripla_BP_6) 		4 SER A 234
ALA A 233
GLN A 243
THR A 253
 None
 1.33A 5n0sA-4mptA:
undetectable		 5n0sA-4mptA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1q ADHESIN/INVASIN TIBA
AUTOTRANSPORTER

(Escherichia
coli) 		PF16168
(AIDA) 		4 SER A 135
ALA A 136
GLN A 166
THR A 139
 289  A 434 (-1.4A)
None
None
None
 1.21A 5n0sA-4q1qA:
undetectable		 5n0sA-4q1qA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1q ADHESIN/INVASIN TIBA
AUTOTRANSPORTER

(Escherichia
coli) 		PF16168
(AIDA) 		4 SER A 154
ALA A 155
GLN A 185
THR A 158
 289  A 410 ( 1.3A)
None
None
None
 1.18A 5n0sA-4q1qA:
undetectable		 5n0sA-4q1qA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1q ADHESIN/INVASIN TIBA
AUTOTRANSPORTER

(Escherichia
coli) 		PF16168
(AIDA) 		4 SER A 230
ALA A 231
GLN A 260
THR A 234
 289  A 416 (-1.3A)
None
None
None
 1.26A 5n0sA-4q1qA:
undetectable		 5n0sA-4q1qA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
kefiri) 		PF13561
(adh_short_C2) 		4 SER A 169
ALA A 170
GLN A 127
THR A 122
 None
 1.26A 5n0sA-4rf3A:
1.9		 5n0sA-4rf3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 SER A 714
ALA A 711
GLN A 664
THR A 674
 None
 1.42A 5n0sA-4rvwA:
undetectable		 5n0sA-4rvwA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v39 SIALYLTRANSFERASE

(Pasteurella
dagmatis) 		PF11477
(PM0188) 		4 SER A 328
ALA A 327
GLN A 257
THR A 345
 None
 1.38A 5n0sA-4v39A:
undetectable		 5n0sA-4v39A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE IRON
PROTEIN 1

(Azotobacter
vinelandii) 		PF00142
(Fer4_NifH) 		4 SER E  44
ALA E  42
GLN E  54
THR E  56
 None
 1.29A 5n0sA-4wzbE:
undetectable		 5n0sA-4wzbE:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcw MOLYBDOPTERIN
ADENYLYLTRANSFERASE

(Helicobacter
pylori) 		PF00994
(MoCF_biosynth) 		4 SER A  12
ALA A  11
GLN A 119
THR A  84
 None
 1.32A 5n0sA-4xcwA:
undetectable		 5n0sA-4xcwA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xea PEPTIDASE M16 DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 SER A 310
ALA A 311
GLN A 314
THR A 322
 None
 1.39A 5n0sA-4xeaA:
undetectable		 5n0sA-4xeaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwj PHOSPHOCARRIER
PROTEIN HPR

(Escherichia
coli) 		PF00381
(PTS-HPr) 		4 SER B  43
ALA B  42
GLN B  51
THR B  52
 None
 1.13A 5n0sA-4xwjB:
undetectable		 5n0sA-4xwjB:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3y THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 SER A 134
ALA A  73
GLN A 119
THR A  41
 None
 1.23A 5n0sA-5a3yA:
undetectable		 5n0sA-5a3yA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejy MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00784
(MyTH4) 		4 SER A 206
ALA A 203
GLN A 191
THR A 189
 None
 1.32A 5n0sA-5ejyA:
undetectable		 5n0sA-5ejyA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO

(Homo sapiens) 		PF12933
(FTO_NTD)
PF12934
(FTO_CTD) 		4 SER A 240
ALA A 241
GLN A 147
THR A 150
 None
 1.38A 5n0sA-5f8pA:
undetectable		 5n0sA-5f8pA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 SER A 319
ALA A 320
GLN A 264
THR A 322
 None
 1.34A 5n0sA-5fp1A:
undetectable		 5n0sA-5fp1A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fvn OMPC PORIN

(Enterobacter
cloacae) 		PF00267
(Porin_1) 		4 SER A 179
ALA A 193
GLN A 122
THR A 101
 None
 1.48A 5n0sA-5fvnA:
undetectable		 5n0sA-5fvnA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwx GLUTAMATE RECEPTOR 4

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 SER B 277
ALA B 278
GLN B 242
THR B 337
 None
 1.38A 5n0sA-5fwxB:
undetectable		 5n0sA-5fwxB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mog PHYTOENE
DEHYDROGENASE,
CHLOROPLASTIC/CHROMO
PLASTIC

(Oryza sativa) 		PF01593
(Amino_oxidase) 		4 SER A 540
ALA A 539
GLN A 292
THR A 508
 FAD  A 600 ( 4.3A)
None
None
None
 1.38A 5n0sA-5mogA:
undetectable		 5n0sA-5mogA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0o PEPTIDE
N-METHYLTRANSFERASE

(Omphalotus
olearius) 		no annotation 4 SER A 129
ALA A 130
GLN A 172
THR A 245
 SAM  A 501 (-4.7A)
SAM  A 501 (-3.2A)
HSE  A 504 ( 3.3A)
SAM  A 501 (-3.6A)
 0.10A 5n0sA-5n0oA:
43.8		 5n0sA-5n0oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nen LIPASE C

(Serratia
marcescens) 		no annotation 4 SER A 256
ALA A 255
GLN A  88
THR A  92
 None
 1.35A 5n0sA-5nenA:
undetectable		 5n0sA-5nenA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 4 SER A 191
ALA A 188
GLN A 481
THR A 482
 DIO  A 614 (-4.5A)
DIO  A 614 (-3.9A)
None
None
 1.27A 5n0sA-5nitA:
undetectable		 5n0sA-5nitA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9c OSMOPORIN OMP36

(Klebsiella
aerogenes) 		no annotation 4 SER C 180
ALA C 194
GLN C 123
THR C 102
 None
 1.45A 5n0sA-5o9cC:
undetectable		 5n0sA-5o9cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu0 LMO2125 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		4 SER A 248
ALA A 249
GLN A 244
THR A 190
 None
 1.18A 5n0sA-5tu0A:
undetectable		 5n0sA-5tu0A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj1 DNA TOPOISOMERASE 1

(Mycobacterium
tuberculosis) 		no annotation 4 SER A 353
ALA A 354
GLN A 361
THR A 427
 None
 1.23A 5n0sA-5uj1A:
2.9		 5n0sA-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 SER A1225
ALA A1226
GLN A 580
THR A 999
 None
 1.41A 5n0sA-5ujaA:
undetectable		 5n0sA-5ujaA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlq LOC100158544 PROTEIN

(Xenopus
tropicalis) 		PF03133
(TTL) 		4 SER A 524
ALA A 523
GLN A 520
THR A 144
 None
None
ANP  A 601 (-3.3A)
None
 1.39A 5n0sA-5vlqA:
undetectable		 5n0sA-5vlqA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgr SPIKE PROTEIN S1

(Pipistrellus
bat coronavirus
HKU5) 		PF09408
(Spike_rec_bind) 		4 SER A 149
ALA A 148
GLN A 157
THR A 166
 None
 1.22A 5n0sA-5xgrA:
undetectable		 5n0sA-5xgrA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 SER A 346
ALA A 347
GLN A 389
THR A 390
 None
 1.42A 5n0sA-6ez8A:
undetectable		 5n0sA-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 4 SER A 207
ALA A 208
GLN A 674
THR A 233
 None
 1.34A 5n0sA-6fuyA:
undetectable		 5n0sA-6fuyA:
undetectable