SIMILAR PATTERNS OF AMINO ACIDS FOR 5N0O_B_SAMB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)

(Trypanosoma
cruzi) 		PF00155
(Aminotran_1_2) 		5 GLY A 249
VAL A  84
ALA A 220
PHE A  92
VAL A 236
 None
 1.03A 5n0oB-1bw0A:
2.3		 5n0oB-1bw0A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e7s GDP-FUCOSE
SYNTHETASE

(Escherichia
coli) 		PF01370
(Epimerase) 		5 ILE A 260
ALA A 257
PHE A 272
ALA A 261
VAL A 199
 None
 1.06A 5n0oB-1e7sA:
0.0		 5n0oB-1e7sA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewr DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 GLY A 731
ALA A 733
PHE A 698
TYR A 737
ALA A 714
 None
 1.12A 5n0oB-1ewrA:
2.4		 5n0oB-1ewrA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 ILE A  88
GLY A  84
HIS A  83
TYR A 195
ALA A 102
 None
 1.14A 5n0oB-1ex9A:
2.7		 5n0oB-1ex9A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A 253
GLY A 255
PHE A 449
TYR A 163
ALA A 200
 None
 1.07A 5n0oB-1g8xA:
1.4		 5n0oB-1g8xA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		5 ILE A 402
GLY A 403
HIS A 405
VAL A 466
ALA A 445
 None
None
None
None
TTP  A1589 (-4.8A)
 1.02A 5n0oB-1h79A:
2.3		 5n0oB-1h79A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		5 ILE S 262
GLY S 264
PHE S 460
TYR S 161
ALA S 198
 None
 1.09A 5n0oB-1i84S:
undetectable		 5n0oB-1i84S:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqc DI-HEME PEROXIDASE

(Nitrosomonas
europaea) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 ILE A 142
GLY A  22
VAL A 127
ALA A 143
ALA A  93
 HEM  A 401 (-4.4A)
None
None
None
HEM  A 401 ( 4.6A)
 1.12A 5n0oB-1iqcA:
undetectable		 5n0oB-1iqcA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ILE A 264
GLY A 266
PHE A 460
TYR A 174
ALA A 211
 None
 1.04A 5n0oB-1jx2A:
1.7		 5n0oB-1jx2A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		5 ILE A 167
GLY A 170
ALA A 139
ALA A 290
VAL A  70
 None
 1.16A 5n0oB-1l8wA:
undetectable		 5n0oB-1l8wA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ILE A  30
GLY A 132
SER A 129
ALA A 128
ALA A  32
 None
 1.08A 5n0oB-1oypA:
undetectable		 5n0oB-1oypA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 ILE A 258
GLY A 257
VAL A  16
SER A 287
ALA A 288
 None
 1.07A 5n0oB-1rf5A:
undetectable		 5n0oB-1rf5A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		5 GLY A 316
HIS A  59
VAL A 319
SER A  60
VAL A 242
 PLP  A 962 (-3.4A)
None
None
PLP  A 962 ( 4.7A)
PLP  A 962 (-4.8A)
 1.03A 5n0oB-1tdjA:
undetectable		 5n0oB-1tdjA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0m ENDO-1,4-BETA-XYLANA
SE A

(Streptomyces
lividans) 		PF00331
(Glyco_hydro_10) 		5 ILE A  20
SER A  22
ALA A  21
ALA A  19
VAL A 268
 None
 1.11A 5n0oB-1v0mA:
undetectable		 5n0oB-1v0mA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6u ENDO-1,4-BETA-D-XYLA
NASE

(Streptomyces
olivaceoviridis) 		PF00331
(Glyco_hydro_10)
PF00652
(Ricin_B_lectin) 		5 ILE A  20
SER A  22
ALA A  21
ALA A  19
VAL A 268
 None
 1.08A 5n0oB-1v6uA:
undetectable		 5n0oB-1v6uA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Nostoc sp. PCC
7120) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 GLY A 251
ALA A 313
PHE A 112
ALA A 315
VAL A 118
 None
 1.13A 5n0oB-1vquA:
undetectable		 5n0oB-1vquA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9y CYSTEINE PROTEINASE

(Staphylococcus
aureus) 		PF05543
(Peptidase_C47)
PF14731
(Staphopain_pro) 		5 ILE A 350
GLY A  66
VAL A 105
ALA A  70
ALA A 348
 None
 1.03A 5n0oB-1x9yA:
undetectable		 5n0oB-1x9yA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		5 ILE A 110
GLY A  93
PHE A 309
TYR A 160
ALA A 161
 None
SEP  A  92 ( 2.4A)
None
None
None
 1.10A 5n0oB-1zefA:
2.5		 5n0oB-1zefA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		5 ILE A 110
GLY A 158
VAL A 145
SER A 155
ALA A 154
 None
None
None
MG  A 903 (-2.1A)
SEP  A  92 ( 3.7A)
 1.16A 5n0oB-1zefA:
2.5		 5n0oB-1zefA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU) 		5 ILE B 157
GLY B 156
SER B 153
ALA B 152
ALA B 131
 None
 1.11A 5n0oB-1zunB:
undetectable		 5n0oB-1zunB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		5 ILE A 182
HIS A 143
PHE A  93
VAL A  95
ALA A 208
 None
None
EDO  A 404 ( 4.6A)
None
None
 1.11A 5n0oB-2ashA:
undetectable		 5n0oB-2ashA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bma GLUTAMATE
DEHYDROGENASE
(NADP+)

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ILE A 111
TYR A  81
GLY A 124
PHE A 105
VAL A 103
 None
 1.12A 5n0oB-2bmaA:
undetectable		 5n0oB-2bmaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 ILE A1181
GLY A1177
ALA A1193
ALA A1209
VAL A1168
 None
 1.13A 5n0oB-2bruA:
undetectable		 5n0oB-2bruA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Homo sapiens) 		PF00698
(Acyl_transf_1) 		5 ILE A  88
GLY A  33
PHE A 233
ALA A  87
VAL A 139
 None
AE4  A1346 (-3.7A)
None
None
None
 1.15A 5n0oB-2c2nA:
undetectable		 5n0oB-2c2nA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddt SPHINGOMYELIN
PHOSPHODIESTERASE

(Bacillus cereus) 		PF03372
(Exo_endo_phos) 		5 ILE A 255
GLY A 193
VAL A 103
ALA A 301
VAL A  48
 None
 1.15A 5n0oB-2ddtA:
undetectable		 5n0oB-2ddtA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e87 HYPOTHETICAL PROTEIN
PH1320

(Pyrococcus
horikoshii) 		PF06858
(NOG1) 		5 ILE A 323
GLY A 322
SER A 316
ALA A 317
ALA A 186
 None
None
GDP  A 400 (-3.1A)
GDP  A 400 (-3.7A)
None
 1.05A 5n0oB-2e87A:
2.2		 5n0oB-2e87A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus) 		PF02171
(Piwi) 		5 ILE A 395
VAL A 420
SER A 358
TYR A 427
ALA A 397
 None
 1.09A 5n0oB-2f8tA:
3.0		 5n0oB-2f8tA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i99 MU-CRYSTALLIN
HOMOLOG

(Homo sapiens) 		PF02423
(OCD_Mu_crystall) 		5 ILE A 154
VAL A 114
SER A 150
ALA A 121
ALA A 125
 None
 1.13A 5n0oB-2i99A:
undetectable		 5n0oB-2i99A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq9 ENDONUCLEASE 4

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		5 ILE A 126
GLY A 111
HIS A 109
PHE A  91
ALA A 127
 None
None
ZN  A 401 (-3.2A)
None
None
 1.03A 5n0oB-2nq9A:
undetectable		 5n0oB-2nq9A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		5 ILE A 339
VAL A 381
SER A 368
ALA A 369
ALA A 337
 None
 1.08A 5n0oB-2nsmA:
undetectable		 5n0oB-2nsmA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 ILE A  10
GLY A  90
VAL A 184
ALA A  29
VAL A 242
 None
 1.06A 5n0oB-2ntjA:
2.3		 5n0oB-2ntjA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6h HYPOTHETICAL PROTEIN

(Aeropyrum
pernix) 		PF01894
(UPF0047) 		6 ILE A  93
GLY A  89
HIS A  87
ALA A  47
ALA A  49
VAL A  16
 None
 1.23A 5n0oB-2p6hA:
undetectable		 5n0oB-2p6hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r17 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35

(Homo sapiens) 		PF03635
(Vps35) 		5 ILE C 723
TYR C 727
VAL C 696
ALA C 703
ALA C 707
 None
 1.08A 5n0oB-2r17C:
undetectable		 5n0oB-2r17C:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		5 GLY A 304
SER A 274
PHE A 172
TYR A 107
ALA A  58
 None
 1.12A 5n0oB-2w61A:
undetectable		 5n0oB-2w61A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio) 		PF00514
(Arm) 		5 ILE A 230
GLY A 226
HIS A 223
SER A 221
VAL A 198
 None
 1.13A 5n0oB-2z6gA:
undetectable		 5n0oB-2z6gA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		5 ILE A 231
GLY A 227
HIS A 224
SER A 222
VAL A 199
 None
 1.11A 5n0oB-2z6hA:
undetectable		 5n0oB-2z6hA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		5 GLY B 287
VAL B 341
TYR B 328
ALA B 296
VAL B 283
 None
 1.01A 5n0oB-3aeqB:
3.7		 5n0oB-3aeqB:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 210
GLY A 213
VAL A 171
SER A 211
VAL A 221
 FAD  A 616 (-4.3A)
None
None
FAD  A 616 (-3.0A)
None
 1.16A 5n0oB-3b96A:
undetectable		 5n0oB-3b96A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE

(Escherichia
coli) 		PF01323
(DSBA) 		5 ILE A  14
GLY A 170
VAL A  51
ALA A 153
VAL A  24
 None
 1.12A 5n0oB-3c7mA:
undetectable		 5n0oB-3c7mA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1e THIOESTERASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF03061
(4HBT) 		6 GLY A  67
PHE A  15
VAL A  11
SER A  64
ALA A  65
ALA A 116
 None
 1.50A 5n0oB-3e1eA:
undetectable		 5n0oB-3e1eA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbg PUTATIVE ARGINATE
LYASE

(Staphylococcus
haemolyticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 168
GLY A 127
ALA A 165
PHE A 220
ALA A 169
 None
 1.16A 5n0oB-3fbgA:
undetectable		 5n0oB-3fbgA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwz INNER MEMBRANE
PROTEIN YBAL

(Escherichia
coli) 		PF02254
(TrkA_N) 		5 ILE A 524
GLY A 492
HIS A 516
ALA A 513
ALA A 529
 None
 1.06A 5n0oB-3fwzA:
undetectable		 5n0oB-3fwzA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 168
GLY A 164
ALA A 180
ALA A 195
VAL A 154
 None
 1.14A 5n0oB-3gazA:
2.4		 5n0oB-3gazA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gem SHORT CHAIN
DEHYDROGENASE

(Pseudomonas
savastanoi) 		PF13561
(adh_short_C2) 		5 ILE A  10
HIS A  30
ALA A  22
ALA A  13
VAL A  17
 None
 1.08A 5n0oB-3gemA:
2.1		 5n0oB-3gemA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF02738
(Ald_Xan_dh_C2) 		5 PHE B 179
VAL B 181
SER B  87
ALA B  86
ALA B  83
 None
None
MCN  B 921 (-4.2A)
NIO  B5661 ( 3.7A)
None
 1.16A 5n0oB-3hrdB:
undetectable		 5n0oB-3hrdB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens) 		PF00514
(Arm) 		5 ILE A 222
GLY A 218
HIS A 215
SER A 213
VAL A 190
 None
None
SO4  A 101 (-4.4A)
None
None
 1.15A 5n0oB-3ifqA:
undetectable		 5n0oB-3ifqA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		5 ILE A  65
GLY A  10
PHE A 198
ALA A  64
VAL A 112
 None
None
ACT  A 500 (-4.8A)
None
None
 1.04A 5n0oB-3im8A:
undetectable		 5n0oB-3im8A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3itd 17BETA-HYDROXYSTEROI
D DEHYDROGENASE

(Curvularia
lunata) 		PF13561
(adh_short_C2) 		5 ILE A  63
GLY A  39
HIS A  37
ALA A  35
VAL A  46
 None
 1.14A 5n0oB-3itdA:
undetectable		 5n0oB-3itdA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izq ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF08938
(HBS1_N) 		5 ILE 1 305
GLY 1 304
SER 1 301
ALA 1 300
ALA 1 272
 None
 1.00A 5n0oB-3izq1:
1.9		 5n0oB-3izq1:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		5 ILE A 262
GLY A 264
PHE A 460
TYR A 161
ALA A 198
 None
 1.04A 5n0oB-3j04A:
undetectable		 5n0oB-3j04A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		5 ILE A 473
PHE A 387
ALA A 476
PHE A 386
VAL A 320
 None
 1.12A 5n0oB-3m62A:
undetectable		 5n0oB-3m62A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgg METHYLTRANSFERASE

(Methanosarcina
mazei) 		PF13847
(Methyltransf_31) 		5 ILE A  46
GLY A  45
PHE A 111
VAL A 112
ALA A  48
 None
 1.15A 5n0oB-3mggA:
undetectable		 5n0oB-3mggA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5c CYTOCHROME C551
PEROXIDASE

(Shewanella
oneidensis) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 ILE A 163
GLY A  43
VAL A 148
ALA A 164
ALA A 114
 HEM  A 401 (-4.4A)
None
None
None
HEM  A 401 ( 4.1A)
 1.11A 5n0oB-3o5cA:
undetectable		 5n0oB-3o5cA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 359
GLY A 360
VAL A  36
ALA A 365
ALA A 368
 None
 1.03A 5n0oB-3otrA:
undetectable		 5n0oB-3otrA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		5 ILE A 305
GLY A 304
SER A 301
ALA A 300
ALA A 272
 None
 0.98A 5n0oB-3p27A:
undetectable		 5n0oB-3p27A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)

(Mycobacterium
tuberculosis) 		PF03602
(Cons_hypoth95) 		5 ILE A  82
GLY A  53
VAL A 101
ALA A  79
ALA A  83
 None
 1.16A 5n0oB-3p9nA:
undetectable		 5n0oB-3p9nA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		5 GLY A 395
HIS A 422
ALA A 441
PHE A 480
ALA A  24
 None
 1.10A 5n0oB-3ptkA:
undetectable		 5n0oB-3ptkA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzj PROBABLE
ACETYLTRANSFERASES

(Chromobacterium
violaceum) 		PF13302
(Acetyltransf_3) 		5 TYR A  91
GLY A 106
HIS A 121
VAL A  83
ALA A 145
 None
None
EDO  A 207 (-4.0A)
NA  A 301 (-4.3A)
None
 1.00A 5n0oB-3pzjA:
undetectable		 5n0oB-3pzjA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		5 ILE A 225
GLY A 156
VAL A 103
ALA A 158
ALA A 238
 None
 1.06A 5n0oB-3q6tA:
undetectable		 5n0oB-3q6tA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl9 CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		5 ILE A 231
GLY A 227
HIS A 224
SER A 222
VAL A 199
 None
 1.11A 5n0oB-3sl9A:
undetectable		 5n0oB-3sl9A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 ILE A  39
SER A  23
ALA A  22
ALA A  47
VAL A  64
 None
 1.01A 5n0oB-3vr5A:
1.8		 5n0oB-3vr5A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		5 ILE A 269
GLY A 137
SER A 271
ALA A 535
VAL A 234
 None
 1.09A 5n0oB-3vtaA:
undetectable		 5n0oB-3vtaA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		5 PHE A  81
VAL A  83
ALA A   9
ALA A   7
VAL A  98
 None
 1.16A 5n0oB-4aioA:
2.4		 5n0oB-4aioA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN

(Thermotoga
maritima) 		PF06964
(Alpha-L-AF_C) 		5 ILE A 169
GLY A 168
ALA A 209
ALA A 191
VAL A 228
 None
 1.05A 5n0oB-4atwA:
undetectable		 5n0oB-4atwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 5 ILE A  49
GLY A 492
HIS A 494
VAL A 320
ALA A  44
 None
 1.07A 5n0oB-4bb9A:
3.5		 5n0oB-4bb9A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dup QUINONE
OXIDOREDUCTASE

(Rhizobium etli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 163
GLY A 159
ALA A 175
ALA A 191
VAL A 149
 None
 1.11A 5n0oB-4dupA:
undetectable		 5n0oB-4dupA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 ILE A 395
VAL A  26
SER A 392
ALA A 342
ALA A 327
 None
 1.08A 5n0oB-4dykA:
undetectable		 5n0oB-4dykA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzh AMIDOHYDROLASE

(Xanthomonas
campestris) 		PF01979
(Amidohydro_1) 		5 ILE A 401
VAL A  23
SER A 398
ALA A 348
ALA A 333
 None
 1.15A 5n0oB-4dzhA:
undetectable		 5n0oB-4dzhA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 5 ILE D 253
GLY D 235
HIS D 237
ALA D 239
PHE D 129
 None
 1.06A 5n0oB-4em6D:
2.1		 5n0oB-4em6D:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewf BETA-LACTAMASE

(Sphaerobacter
thermophilus) 		PF13354
(Beta-lactamase2) 		5 GLY A 254
VAL A 236
ALA A 252
ALA A 248
VAL A 221
 None
 1.12A 5n0oB-4ewfA:
undetectable		 5n0oB-4ewfA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF12741
(SusD-like) 		5 ILE A 375
GLY A 374
SER A 371
ALA A 370
ALA A 249
 None
 1.16A 5n0oB-4f7aA:
undetectable		 5n0oB-4f7aA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi2 CROTONYL-COA
CARBOXYLASE/REDUCTAS
E

(Methylobacterium
extorquens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 216
GLY A 227
VAL A 376
ALA A 238
VAL A 251
 None
 1.15A 5n0oB-4gi2A:
3.8		 5n0oB-4gi2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		5 ILE A 241
GLY A 116
VAL A 172
ALA A 120
ALA A 239
 None
 1.00A 5n0oB-4hy3A:
undetectable		 5n0oB-4hy3A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		5 ILE A  10
GLY A  87
VAL A 179
ALA A  27
VAL A 230
 None
 1.06A 5n0oB-4ituA:
undetectable		 5n0oB-4ituA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		5 GLY A 151
VAL A 281
SER A 170
ALA A 169
VAL A 306
 None
 0.99A 5n0oB-4kv7A:
2.5		 5n0oB-4kv7A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 5 ILE A  49
GLY A 492
HIS A 494
VAL A 320
ALA A  44
 None
 1.10A 5n0oB-4lc9A:
undetectable		 5n0oB-4lc9A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4neg TRYPTOPHAN SYNTHASE
BETA CHAIN

(Bacillus
anthracis) 		PF00291
(PALP) 		5 GLY A 139
VAL A 150
TYR A 190
ALA A 177
VAL A 135
 None
 1.16A 5n0oB-4negA:
2.3		 5n0oB-4negA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.04A 5n0oB-4o7dA:
undetectable		 5n0oB-4o7dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A 256
GLY A 258
PHE A 454
TYR A 162
ALA A 199
 None
 1.16A 5n0oB-4pd3A:
3.1		 5n0oB-4pd3A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqs GLYCOSIDE HYDROLASE
FAMILY 43

(Halothermothrix
orenii) 		PF04616
(Glyco_hydro_43) 		5 ILE A 222
TYR A 272
GLY A 255
SER A 221
VAL A 301
 None
 1.11A 5n0oB-4qqsA:
undetectable		 5n0oB-4qqsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		6 GLY A 207
HIS A 209
VAL A 196
SER A 205
ALA A 204
ALA A 231
 None
 1.44A 5n0oB-4qwwA:
undetectable		 5n0oB-4qwwA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rph UDP-GALACTOPYRANOSE
MUTASE

(Mycobacterium
tuberculosis) 		no annotation 5 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.91A 5n0oB-4rphB:
undetectable		 5n0oB-4rphB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 177
GLY A 173
VAL A 259
ALA A 206
VAL A 164
 None
 1.11A 5n0oB-4uekA:
3.1		 5n0oB-4uekA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 ILE A 358
GLY A 391
VAL A 397
PHE A 350
ALA A 357
 None
 0.96A 5n0oB-4umvA:
undetectable		 5n0oB-4umvA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unf ENDONUCLEASE III-1

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		5 ILE A 179
GLY A 177
PHE A 246
ALA A 187
VAL A 169
 None
 1.05A 5n0oB-4unfA:
undetectable		 5n0oB-4unfA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		5 ILE A 142
GLY A 186
VAL A 169
ALA A 138
VAL A 104
 None
 1.05A 5n0oB-4wnzA:
undetectable		 5n0oB-4wnzA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yai C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		6 ILE A  10
GLY A  13
PHE A  48
ALA A  22
PHE A  49
ALA A   8
 None
 1.44A 5n0oB-4yaiA:
2.7		 5n0oB-4yaiA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv4 ELONGATION FACTOR TU

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 ILE A  18
TYR A  88
HIS A  23
ALA A 102
VAL A  80
 None
 1.13A 5n0oB-4zv4A:
undetectable		 5n0oB-4zv4A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 ILE A 493
GLY A 519
HIS A 521
PHE A 473
ALA A 485
 None
 1.03A 5n0oB-5d3oA:
undetectable		 5n0oB-5d3oA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fim YGAU

(Escherichia
coli) 		PF01476
(LysM)
PF04972
(BON) 		5 ILE A  50
GLY A  53
PHE A   6
ALA A  55
ALA A  28
 None
 0.90A 5n0oB-5fimA:
undetectable		 5n0oB-5fimA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A 276
GLY A 278
PHE A 473
TYR A 182
ALA A 219
 None
 1.09A 5n0oB-5i4eA:
2.3		 5n0oB-5i4eA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m28 MALE1

(Lactobacillus
casei) 		PF13416
(SBP_bac_8) 		5 GLY A 269
VAL A 312
ALA A 129
TYR A 252
ALA A 266
 None
 1.11A 5n0oB-5m28A:
undetectable		 5n0oB-5m28A:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n0o PEPTIDE
N-METHYLTRANSFERASE

(Omphalotus
olearius) 		no annotation 7 ILE A  19
GLY A  18
SER A 129
ALA A 130
TYR A 211
ALA A 213
VAL A 243
 SAM  A 501 (-4.5A)
None
SAM  A 501 (-4.7A)
SAM  A 501 (-3.2A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.0A)
 0.98A 5n0oB-5n0oA:
46.0		 5n0oB-5n0oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n0o PEPTIDE
N-METHYLTRANSFERASE

(Omphalotus
olearius) 		no annotation 12 ILE A  19
TYR A  98
GLY A  99
HIS A 100
PHE A 104
VAL A 105
SER A 129
ALA A 130
PHE A 171
TYR A 211
ALA A 213
VAL A 243
 SAM  A 501 (-4.5A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.5A)
None
None
None
SAM  A 501 (-4.7A)
SAM  A 501 (-3.2A)
SAM  A 501 (-4.3A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.0A)
 0.07A 5n0oB-5n0oA:
46.0		 5n0oB-5n0oA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 GLY B 474
HIS B 473
VAL B 468
ALA B 509
VAL B 489
 None
 0.95A 5n0oB-5up2B:
2.0		 5n0oB-5up2B:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqd DUMPY: SHORTER THAN
WILD-TYPE

(Caenorhabditis
elegans) 		no annotation 5 ILE A1506
GLY A1505
PHE A1409
TYR A1335
ALA A1339
 None
 1.13A 5n0oB-5uqdA:
undetectable		 5n0oB-5uqdA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase)
PF12796
(Ank_2) 		5 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.05A 5n0oB-5uqeA:
undetectable		 5n0oB-5uqeA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE

(Methanosarcinales) 		no annotation 5 ILE A 469
GLY A 470
ALA A 391
ALA A 395
VAL A 459
 ADP  A 501 (-3.5A)
ADP  A 501 (-3.4A)
ADP  A 501 ( 4.5A)
ADP  A 501 ( 3.9A)
ADP  A 501 ( 3.9A)
 1.04A 5n0oB-6c8zA:
undetectable		 5n0oB-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhv GLUCOAMYLASE

(Penicillium
oxalicum) 		no annotation 5 ILE A  91
ALA A  87
PHE A  64
ALA A 168
VAL A 116
 None
 1.10A 5n0oB-6fhvA:
undetectable		 5n0oB-6fhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 5 TYR A 503
GLY A 504
VAL A 620
SER A 556
ALA A 563
 None
 1.11A 5n0oB-6fikA:
undetectable		 5n0oB-6fikA:
undetectable