SIMILAR PATTERNS OF AMINO ACIDS FOR 5N0O_A_SAMA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg4 ENDO-1,4-BETA-XYLANA
SE

(Penicillium
simplicissimum) 		PF00331
(Glyco_hydro_10) 		5 ILE A 205
GLY A 206
PHE A 134
ALA A 229
VAL A 185
 None
None
None
NA  A 619 ( 3.8A)
None
 1.18A 5n0oA-1bg4A:
undetectable		 5n0oA-1bg4A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ILE A 262
GLY A 264
PHE A 460
TYR A 161
ALA A 198
 None
 1.17A 5n0oA-1br2A:
1.7		 5n0oA-1br2A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 ILE A  88
GLY A  84
HIS A  83
TYR A 195
ALA A 102
 None
 1.12A 5n0oA-1ex9A:
undetectable		 5n0oA-1ex9A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A 253
GLY A 255
PHE A 449
TYR A 163
ALA A 200
 None
 1.06A 5n0oA-1g8xA:
undetectable		 5n0oA-1g8xA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		5 ILE A 402
GLY A 403
HIS A 405
VAL A 466
ALA A 445
 None
None
None
None
TTP  A1589 (-4.8A)
 1.02A 5n0oA-1h79A:
1.6		 5n0oA-1h79A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		5 ILE S 262
GLY S 264
PHE S 460
TYR S 161
ALA S 198
 None
 1.08A 5n0oA-1i84S:
undetectable		 5n0oA-1i84S:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ILE A 264
GLY A 266
PHE A 460
TYR A 174
ALA A 211
 None
 1.03A 5n0oA-1jx2A:
1.5		 5n0oA-1jx2A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llu ALCOHOL
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 180
HIS A 184
VAL A 185
VAL A 187
VAL A 242
 NAD  A1250 (-3.4A)
None
None
None
None
 1.18A 5n0oA-1lluA:
1.3		 5n0oA-1lluA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0u GST2 GENE PRODUCT

(Drosophila
melanogaster) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ILE A 205
GLY A 204
VAL A 228
VAL A 231
VAL A 138
 None
 1.07A 5n0oA-1m0uA:
undetectable		 5n0oA-1m0uA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1

(Pinus taeda) 		PF05368
(NmrA) 		5 ILE A 266
VAL A 187
SER A 267
ALA A 127
VAL A 121
 None
 1.16A 5n0oA-1qycA:
3.2		 5n0oA-1qycA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		5 GLY A 316
HIS A  59
VAL A 319
SER A  60
VAL A 242
 PLP  A 962 (-3.4A)
None
None
PLP  A 962 ( 4.7A)
PLP  A 962 (-4.8A)
 1.01A 5n0oA-1tdjA:
undetectable		 5n0oA-1tdjA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhv DIPHTHINE SYNTHASE

(Archaeoglobus
fulgidus) 		PF00590
(TP_methylase) 		5 GLY A  83
VAL A  87
SER A 112
PHE A 159
ALA A 194
 None
 0.84A 5n0oA-1vhvA:
5.4		 5n0oA-1vhvA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wde PROBABLE DIPHTHINE
SYNTHASE

(Aeropyrum
pernix) 		PF00590
(TP_methylase) 		5 GLY A  92
VAL A  96
SER A 121
ALA A 218
VAL A 244
 None
 1.01A 5n0oA-1wdeA:
6.6		 5n0oA-1wdeA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu7 HISTIDYL-TRNA
SYNTHETASE

(Thermoplasma
acidophilum) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 TYR A 351
HIS A 420
VAL A 412
VAL A 399
SER A 416
 None
 1.12A 5n0oA-1wu7A:
undetectable		 5n0oA-1wu7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 ILE A 625
GLY A 297
VAL A 245
PHE A 247
ALA A 617
 None
 1.16A 5n0oA-1xjeA:
undetectable		 5n0oA-1xjeA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		no annotation 5 ILE A 109
GLY A 455
VAL A 460
PHE A  84
ALA A 115
 None
 1.17A 5n0oA-1xksA:
undetectable		 5n0oA-1xksA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		5 ILE A 110
GLY A  93
PHE A 309
TYR A 160
ALA A 161
 None
SEP  A  92 ( 2.4A)
None
None
None
 1.09A 5n0oA-1zefA:
2.3		 5n0oA-1zefA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		5 ILE A 182
HIS A 143
PHE A  93
VAL A  95
ALA A 208
 None
None
EDO  A 404 ( 4.6A)
None
None
 1.10A 5n0oA-2ashA:
undetectable		 5n0oA-2ashA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 ILE A 566
GLY A 427
HIS A 426
VAL A 527
VAL A 531
 None
 1.01A 5n0oA-2b3xA:
undetectable		 5n0oA-2b3xA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Homo sapiens) 		PF00698
(Acyl_transf_1) 		5 ILE A  88
GLY A  33
PHE A 233
ALA A  87
VAL A 139
 None
AE4  A1346 (-3.7A)
None
None
None
 1.15A 5n0oA-2c2nA:
undetectable		 5n0oA-2c2nA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3a GLUTAMINE SYNTHETASE

(Zea mays) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 ILE A 208
VAL A 214
VAL A 216
SER A 210
ALA A 110
 None
 1.15A 5n0oA-2d3aA:
undetectable		 5n0oA-2d3aA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddt SPHINGOMYELIN
PHOSPHODIESTERASE

(Bacillus cereus) 		PF03372
(Exo_endo_phos) 		5 ILE A 255
GLY A 193
VAL A 103
ALA A 301
VAL A  48
 None
 1.13A 5n0oA-2ddtA:
undetectable		 5n0oA-2ddtA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddt SPHINGOMYELIN
PHOSPHODIESTERASE

(Bacillus cereus) 		PF03372
(Exo_endo_phos) 		5 ILE A 255
GLY A 194
VAL A 103
ALA A 301
VAL A  48
 None
 1.18A 5n0oA-2ddtA:
undetectable		 5n0oA-2ddtA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus) 		PF02171
(Piwi) 		5 ILE A 395
VAL A 420
SER A 358
TYR A 427
ALA A 397
 None
 1.08A 5n0oA-2f8tA:
undetectable		 5n0oA-2f8tA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151

(Pyrobaculum
aerophilum) 		PF01850
(PIN) 		5 ILE A  10
VAL A  27
TYR A 103
ALA A  39
VAL A  77
 None
 1.17A 5n0oA-2fe1A:
undetectable		 5n0oA-2fe1A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Sulfurisphaera
tokodaii) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		5 ILE A 329
GLY A 356
VAL A 339
VAL A 341
VAL A 389
 None
 1.10A 5n0oA-2ggqA:
undetectable		 5n0oA-2ggqA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0r NICOTINAMIDASE

(Saccharomyces
cerevisiae) 		PF00857
(Isochorismatase) 		5 ILE A 192
VAL A 198
VAL A 202
SER A 193
TYR A  70
 None
 1.18A 5n0oA-2h0rA:
2.2		 5n0oA-2h0rA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n57 ACYL CARRIER PROTEIN

(Brucella
melitensis) 		PF00550
(PP-binding) 		5 ILE A  63
VAL A   8
VAL A  12
ALA A  59
VAL A  41
 None
 1.11A 5n0oA-2n57A:
undetectable		 5n0oA-2n57A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq9 ENDONUCLEASE 4

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		5 ILE A 126
GLY A 111
HIS A 109
PHE A  91
ALA A 127
 None
None
ZN  A 401 (-3.2A)
None
None
 1.03A 5n0oA-2nq9A:
undetectable		 5n0oA-2nq9A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 ILE A  10
GLY A  90
VAL A 184
ALA A  29
VAL A 242
 None
 1.06A 5n0oA-2ntjA:
2.3		 5n0oA-2ntjA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6d DIPHTHINE SYNTHASE

(Pyrococcus
horikoshii) 		PF00590
(TP_methylase) 		5 GLY A  86
VAL A  90
SER A 115
PHE A 165
ALA A 209
 SAH  A 301 ( 3.7A)
SAH  A 301 (-4.0A)
SAH  A 301 (-2.7A)
SAH  A 301 (-4.8A)
SAH  A 301 (-3.6A)
 1.01A 5n0oA-2p6dA:
6.7		 5n0oA-2p6dA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6h HYPOTHETICAL PROTEIN

(Aeropyrum
pernix) 		PF01894
(UPF0047) 		5 ILE A  93
GLY A  89
HIS A  87
ALA A  49
VAL A  16
 None
 1.14A 5n0oA-2p6hA:
undetectable		 5n0oA-2p6hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF03009
(GDPD) 		5 TYR A  74
GLY A  61
HIS A  59
SER A  63
TYR A 145
 None
None
GOL  A 501 (-3.8A)
None
None
 1.17A 5n0oA-2p76A:
undetectable		 5n0oA-2p76A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF08241
(Methyltransf_11) 		5 ILE A  74
GLY A  50
VAL A  26
VAL A  92
ALA A  61
 GOL  A 212 (-3.8A)
None
None
None
None
 1.07A 5n0oA-2p8jA:
undetectable		 5n0oA-2p8jA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		5 GLY A 304
PHE A 238
SER A 274
TYR A 107
ALA A  58
 None
 1.17A 5n0oA-2w61A:
undetectable		 5n0oA-2w61A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		5 GLY A 304
SER A 274
PHE A 172
TYR A 107
ALA A  58
 None
 1.12A 5n0oA-2w61A:
undetectable		 5n0oA-2w61A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnb -

(Sus scrofa) 		PF00777
(Glyco_transf_29) 		5 ILE A 278
VAL A 147
SER A 276
PHE A 292
VAL A 327
 None
None
None
C5P  A1344 (-4.6A)
None
 1.16A 5n0oA-2wnbA:
undetectable		 5n0oA-2wnbA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsu PUTATIVE FIBER
PROTEIN

(Porcine
mastadenovirus
B) 		PF00337
(Gal-bind_lectin) 		5 ILE A 666
GLY A 555
HIS A 682
VAL A 684
ALA A 591
 None
 1.18A 5n0oA-2wsuA:
undetectable		 5n0oA-2wsuA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 TYR A 611
GLY A 610
VAL A 410
PHE A 402
ALA A 680
 None
 1.16A 5n0oA-2ya2A:
undetectable		 5n0oA-2ya2A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylz PHENYLACETONE
MONOOXYGENASE

(Thermobifida
fusca) 		PF13738
(Pyr_redox_3) 		5 ILE A 199
GLY A 198
VAL A 214
PHE A 348
ALA A 222
 None
 1.12A 5n0oA-2ylzA:
undetectable		 5n0oA-2ylzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00731
(AIRC) 		5 ILE A  58
VAL A  77
PHE A  55
VAL A  54
VAL A  31
 None
 1.16A 5n0oA-2ywxA:
undetectable		 5n0oA-2ywxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio) 		PF00514
(Arm) 		5 ILE A 230
GLY A 226
HIS A 223
SER A 221
VAL A 198
 None
 1.14A 5n0oA-2z6gA:
undetectable		 5n0oA-2z6gA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		5 ILE A 231
GLY A 227
HIS A 224
SER A 222
VAL A 199
 None
 1.12A 5n0oA-2z6hA:
undetectable		 5n0oA-2z6hA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		5 HIS A 202
VAL A 206
SER A 270
ALA A 284
VAL A 261
 None
 1.19A 5n0oA-2zwvA:
2.4		 5n0oA-2zwvA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		5 GLY B 287
VAL B 341
TYR B 328
ALA B 296
VAL B 283
 None
 1.01A 5n0oA-3aeqB:
2.5		 5n0oA-3aeqB:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		5 ILE A 174
VAL A 242
VAL A 234
ALA A 183
VAL A 246
 None
 1.02A 5n0oA-3auoA:
undetectable		 5n0oA-3auoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 210
GLY A 213
VAL A 171
SER A 211
VAL A 221
 FAD  A 616 (-4.3A)
None
None
FAD  A 616 (-3.0A)
None
 1.17A 5n0oA-3b96A:
undetectable		 5n0oA-3b96A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE

(Escherichia
coli) 		PF01323
(DSBA) 		5 ILE A  14
GLY A 170
VAL A  51
ALA A 153
VAL A  24
 None
 1.12A 5n0oA-3c7mA:
undetectable		 5n0oA-3c7mA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cz5 TWO-COMPONENT
RESPONSE REGULATOR,
LUXR FAMILY

(Aurantimonas
manganoxydans) 		PF00072
(Response_reg) 		5 ILE A 122
GLY A 104
VAL A 106
PHE A  85
TYR A  31
 None
 0.99A 5n0oA-3cz5A:
2.3		 5n0oA-3cz5A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cz5 TWO-COMPONENT
RESPONSE REGULATOR,
LUXR FAMILY

(Aurantimonas
manganoxydans) 		PF00072
(Response_reg) 		5 ILE A 122
GLY A 104
VAL A 106
PHE A  85
VAL A  55
 None
 1.14A 5n0oA-3cz5A:
2.3		 5n0oA-3cz5A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e35 UNCHARACTERIZED
PROTEIN SCO1997

(Streptomyces
coelicolor) 		PF09754
(PAC2) 		5 ILE A 129
GLY A 127
VAL A 186
PHE A 122
ALA A  62
 None
 1.16A 5n0oA-3e35A:
undetectable		 5n0oA-3e35A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fip OUTER MEMBRANE USHER
PROTEIN PAPC

(Escherichia
coli) 		PF00577
(Usher) 		5 GLY A 360
VAL A 341
PHE A 357
TYR A 382
ALA A 384
 None
 1.08A 5n0oA-3fipA:
undetectable		 5n0oA-3fipA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum) 		PF00291
(PALP) 		5 ILE A 222
GLY A 219
VAL A 276
VAL A 273
VAL A 241
 None
LLP  A  91 ( 3.5A)
None
None
None
 0.87A 5n0oA-3iauA:
2.2		 5n0oA-3iauA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens) 		PF00514
(Arm) 		5 ILE A 222
GLY A 218
HIS A 215
SER A 213
VAL A 190
 None
None
SO4  A 101 (-4.4A)
None
None
 1.15A 5n0oA-3ifqA:
undetectable		 5n0oA-3ifqA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		5 ILE A 954
TYR A 951
GLY A 952
VAL A1074
ALA A 899
 None
 1.07A 5n0oA-3ikmA:
undetectable		 5n0oA-3ikmA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		5 ILE A  65
GLY A  10
PHE A 198
ALA A  64
VAL A 112
 None
None
ACT  A 500 (-4.8A)
None
None
 1.03A 5n0oA-3im8A:
undetectable		 5n0oA-3im8A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		5 ILE A 262
GLY A 264
PHE A 460
TYR A 161
ALA A 198
 None
 1.04A 5n0oA-3j04A:
undetectable		 5n0oA-3j04A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9q SHEATH

(Pseudomonas
aeruginosa) 		PF04984
(Phage_sheath_1)
PF17482
(Phage_sheath_1C) 		5 ILE A  99
GLY A 100
VAL A  85
VAL A  83
ALA A 138
 None
 1.03A 5n0oA-3j9qA:
undetectable		 5n0oA-3j9qA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqs TRANSFERRIN-BINDING
PROTEIN

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 ILE A 116
GLY A 127
PHE A 278
ALA A 185
VAL A 182
 None
 1.19A 5n0oA-3pqsA:
undetectable		 5n0oA-3pqsA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzj PROBABLE
ACETYLTRANSFERASES

(Chromobacterium
violaceum) 		PF13302
(Acetyltransf_3) 		5 TYR A  91
GLY A 106
HIS A 121
VAL A  83
ALA A 145
 None
None
EDO  A 207 (-4.0A)
NA  A 301 (-4.3A)
None
 0.99A 5n0oA-3pzjA:
undetectable		 5n0oA-3pzjA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl9 CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		5 ILE A 231
GLY A 227
HIS A 224
SER A 222
VAL A 199
 None
 1.12A 5n0oA-3sl9A:
undetectable		 5n0oA-3sl9A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sut BETA-HEXOSAMINIDASE

(Paenibacillus
sp. TS12) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		5 TYR A 161
GLY A 435
VAL A 387
VAL A 366
ALA A 394
 None
 1.19A 5n0oA-3sutA:
undetectable		 5n0oA-3sutA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		5 ILE A 269
GLY A 137
SER A 271
ALA A 535
VAL A 234
 None
 1.09A 5n0oA-3vtaA:
undetectable		 5n0oA-3vtaA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		5 ILE A 224
VAL A 221
PHE A 195
SER A 223
ALA A 271
 None
 1.12A 5n0oA-3vv3A:
undetectable		 5n0oA-3vv3A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 5 ILE A  49
GLY A 492
HIS A 494
VAL A 320
ALA A  44
 None
 1.07A 5n0oA-4bb9A:
2.2		 5n0oA-4bb9A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpd ALCOHOL
DEHYDROGENASE

(Thermus sp.
ATN1) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 185
GLY A 181
VAL A 266
ALA A 214
VAL A 172
 None
None
NAD  A1407 (-4.0A)
None
None
 1.16A 5n0oA-4cpdA:
2.4		 5n0oA-4cpdA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuk D-LACTATE
DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A 238
GLY A 235
VAL A 259
PHE A 292
ALA A 243
 None
 1.14A 5n0oA-4cukA:
undetectable		 5n0oA-4cukA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7z APOCYTOCHROME F

(Mastigocladus
laminosus) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 GLY C 152
VAL C  50
VAL C  34
PHE C 129
VAL C 113
 None
 1.19A 5n0oA-4i7zC:
undetectable		 5n0oA-4i7zC:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		5 ILE A  10
GLY A  87
VAL A 179
ALA A  27
VAL A 230
 None
 1.06A 5n0oA-4ituA:
undetectable		 5n0oA-4ituA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh3 ANTIGEN 43

(Escherichia
coli) 		PF16168
(AIDA) 		5 GLY A  26
HIS A   6
VAL A   4
PHE A  23
VAL A  71
 MLI  A 601 (-3.2A)
None
None
None
None
 1.14A 5n0oA-4kh3A:
undetectable		 5n0oA-4kh3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 5 ILE A  49
GLY A 492
HIS A 494
VAL A 320
ALA A  44
 None
 1.10A 5n0oA-4lc9A:
1.4		 5n0oA-4lc9A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4neg TRYPTOPHAN SYNTHASE
BETA CHAIN

(Bacillus
anthracis) 		PF00291
(PALP) 		5 GLY A 139
VAL A 150
TYR A 190
ALA A 177
VAL A 135
 None
 1.16A 5n0oA-4negA:
undetectable		 5n0oA-4negA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.04A 5n0oA-4o7dA:
undetectable		 5n0oA-4o7dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofw PROTEIN DJ-1 HOMOLOG
D

(Arabidopsis
thaliana) 		PF01965
(DJ-1_PfpI) 		5 ILE A 318
GLY A 315
HIS A 314
VAL A 336
VAL A 324
 None
 1.16A 5n0oA-4ofwA:
undetectable		 5n0oA-4ofwA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A 256
GLY A 258
PHE A 454
TYR A 162
ALA A 199
 None
 1.15A 5n0oA-4pd3A:
2.7		 5n0oA-4pd3A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqs GLYCOSIDE HYDROLASE
FAMILY 43

(Halothermothrix
orenii) 		PF04616
(Glyco_hydro_43) 		5 ILE A 222
TYR A 272
GLY A 255
SER A 221
VAL A 301
 None
 1.10A 5n0oA-4qqsA:
undetectable		 5n0oA-4qqsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY

(Trichormus
variabilis) 		PF13458
(Peripla_BP_6) 		5 ILE A  59
GLY A  58
VAL A 124
VAL A 147
ALA A  78
 None
 1.18A 5n0oA-4rdcA:
3.6		 5n0oA-4rdcA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rph UDP-GALACTOPYRANOSE
MUTASE

(Mycobacterium
tuberculosis) 		no annotation 5 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.91A 5n0oA-4rphB:
undetectable		 5n0oA-4rphB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 177
GLY A 173
VAL A 259
ALA A 206
VAL A 164
 None
 1.10A 5n0oA-4uekA:
2.9		 5n0oA-4uekA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 ILE A 358
GLY A 391
VAL A 397
PHE A 350
ALA A 357
 None
 0.95A 5n0oA-4umvA:
2.7		 5n0oA-4umvA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unf ENDONUCLEASE III-1

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		5 ILE A 179
GLY A 177
PHE A 246
ALA A 187
VAL A 169
 None
 1.06A 5n0oA-4unfA:
undetectable		 5n0oA-4unfA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv4 ELONGATION FACTOR TU

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 ILE A  18
TYR A  88
HIS A  23
ALA A 102
VAL A  80
 None
 1.13A 5n0oA-4zv4A:
2.1		 5n0oA-4zv4A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 ILE A 493
GLY A 519
HIS A 521
PHE A 473
ALA A 485
 None
 1.03A 5n0oA-5d3oA:
undetectable		 5n0oA-5d3oA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		5 ILE A 587
GLY A 627
VAL A 625
PHE A 571
ALA A 591
 None
 1.02A 5n0oA-5e7pA:
3.5		 5n0oA-5e7pA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct) 		PF00291
(PALP) 		5 GLY B 132
VAL B 143
TYR B 183
ALA B 170
VAL B 128
 None
 1.19A 5n0oA-5ey5B:
undetectable		 5n0oA-5ey5B:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ILE A 129
VAL A  40
VAL A 134
SER A 131
VAL A  96
 None
 1.16A 5n0oA-5fr8A:
undetectable		 5n0oA-5fr8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans) 		PF01580
(FtsK_SpoIIIE) 		5 ILE A1282
HIS A1279
VAL A1408
PHE A1374
VAL A1373
 None
 1.07A 5n0oA-5fv0A:
undetectable		 5n0oA-5fv0A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01269
(Fibrillarin) 		5 ILE E  91
GLY E  88
VAL E  38
SER E  92
ALA E 104
 None
 1.06A 5n0oA-5ginE:
undetectable		 5n0oA-5ginE:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hei NFRA2

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		5 ILE A 115
GLY A 114
VAL A 157
SER A 116
ALA A  38
 None
 1.18A 5n0oA-5heiA:
undetectable		 5n0oA-5heiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A 276
GLY A 278
PHE A 473
TYR A 182
ALA A 219
 None
 1.08A 5n0oA-5i4eA:
2.2		 5n0oA-5i4eA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j69 ASTROTACTIN-2

(Homo sapiens) 		PF01823
(MACPF) 		5 ILE A 846
GLY A 850
HIS A 848
VAL A 742
ALA A 978
 None
 1.18A 5n0oA-5j69A:
undetectable		 5n0oA-5j69A:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n0o PEPTIDE
N-METHYLTRANSFERASE

(Omphalotus
olearius) 		no annotation 6 ILE A  19
GLY A  18
SER A 129
TYR A 211
ALA A 213
VAL A 243
 SAM  A 501 (-4.5A)
None
SAM  A 501 (-4.7A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.0A)
 1.04A 5n0oA-5n0oA:
50.1		 5n0oA-5n0oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n0o PEPTIDE
N-METHYLTRANSFERASE

(Omphalotus
olearius) 		no annotation 12 ILE A  19
TYR A  98
GLY A  99
HIS A 100
VAL A 103
PHE A 104
VAL A 105
SER A 129
PHE A 171
TYR A 211
ALA A 213
VAL A 243
 SAM  A 501 (-4.5A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.5A)
None
SAM  A 501 (-4.4A)
None
None
SAM  A 501 (-4.7A)
SAM  A 501 (-4.3A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.0A)
 0.00A 5n0oA-5n0oA:
50.1		 5n0oA-5n0oA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 5 VAL A  43
SER A  37
PHE A 401
ALA A  23
VAL A  51
 None
 1.12A 5n0oA-5ns8A:
undetectable		 5n0oA-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oar BETA-HEXOSAMINIDASE

(Aspergillus
oryzae) 		no annotation 5 TYR B 184
GLY B 511
VAL B 436
VAL B 415
ALA B 514
 None
 1.10A 5n0oA-5oarB:
undetectable		 5n0oA-5oarB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 GLY B 474
HIS B 473
VAL B 468
ALA B 509
VAL B 489
 None
 0.94A 5n0oA-5up2B:
2.5		 5n0oA-5up2B:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqd DUMPY: SHORTER THAN
WILD-TYPE

(Caenorhabditis
elegans) 		no annotation 5 ILE A1506
GLY A1505
PHE A1409
TYR A1335
ALA A1339
 None
 1.13A 5n0oA-5uqdA:
undetectable		 5n0oA-5uqdA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase)
PF12796
(Ank_2) 		5 ILE A 488
GLY A 514
HIS A 516
PHE A 468
ALA A 480
 None
 1.06A 5n0oA-5uqeA:
undetectable		 5n0oA-5uqeA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		5 ILE A 290
VAL A 297
SER A 292
ALA A 176
VAL A 179
 None
 1.18A 5n0oA-5xfaA:
undetectable		 5n0oA-5xfaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 5 TYR A 503
GLY A 504
VAL A 620
SER A 556
ALA A 563
 None
 1.10A 5n0oA-6fikA:
2.7		 5n0oA-6fikA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aa2 BETA-SPECTRIN

(Homo sapiens) 		PF00307
(CH) 		3 ALA A  36
GLN A  13
THR A  16
 None
 0.71A 5n0oA-1aa2A:
undetectable		 5n0oA-1aa2A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avv NEGATIVE FACTOR

(Human
immunodeficiency
virus 1) 		PF00469
(F-protein) 		3 ALA A  84
GLN A 125
THR A 138
 None
 0.69A 5n0oA-1avvA:
undetectable		 5n0oA-1avvA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddb PROTEIN (BID)

(Mus musculus) 		PF06393
(BID) 		3 ALA A 137
GLN A 108
THR A 104
 None
 0.72A 5n0oA-1ddbA:
0.0		 5n0oA-1ddbA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases) 		3 ALA B  79
GLN B 227
THR B 229
 None
F3S  A 267 (-3.4A)
None
 0.60A 5n0oA-1e3dB:
0.0		 5n0oA-1e3dB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		3 ALA A 217
GLN A 306
THR A 378
 None
 0.76A 5n0oA-1e6zA:
0.0		 5n0oA-1e6zA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb6 NEUTRAL PROTEASE II

(Aspergillus
oryzae) 		PF02102
(Peptidase_M35) 		3 ALA A  91
GLN A 122
THR A 125
 None
 0.59A 5n0oA-1eb6A:
0.0		 5n0oA-1eb6A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee1 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Bacillus
subtilis) 		PF02540
(NAD_synthase) 		3 ALA A 198
GLN A  49
THR A  52
 None
 0.75A 5n0oA-1ee1A:
0.0		 5n0oA-1ee1A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ego GLUTAREDOXIN

(Escherichia
coli) 		PF00462
(Glutaredoxin) 		3 ALA A  21
GLN A  32
THR A   3
 None
 0.70A 5n0oA-1egoA:
0.1		 5n0oA-1egoA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fou UPPER COLLAR PROTEIN

(Bacillus virus
phi29) 		PF05352
(Phage_connector) 		3 ALA A  35
GLN A  59
THR A 130
 None
 0.60A 5n0oA-1fouA:
undetectable		 5n0oA-1fouA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE

(Grifola
frondosa) 		PF14521
(Aspzincin_M35) 		3 ALA A  84
GLN A 111
THR A 114
 None
 0.66A 5n0oA-1ge7A:
0.0		 5n0oA-1ge7A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsw L-ASPARTATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 ALA A 283
GLN A 219
THR A 221
 None
 0.71A 5n0oA-1jswA:
undetectable		 5n0oA-1jswA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mza PRO-GRANZYME K

(Homo sapiens) 		PF00089
(Trypsin) 		3 ALA A  55
GLN A  99
THR A 229
 None
 0.72A 5n0oA-1mzaA:
undetectable		 5n0oA-1mzaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		3 ALA A 520
GLN A   5
THR A   9
 None
SF4  A1554 (-4.7A)
SF4  A1554 (-3.9A)
 0.72A 5n0oA-1oa1A:
undetectable		 5n0oA-1oa1A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3w CYSTEINE DESULFURASE

(Escherichia
coli) 		no annotation 3 ALA B  50
GLN B  25
THR B  32
 None
 0.69A 5n0oA-1p3wB:
3.1		 5n0oA-1p3wB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pe9 PECTATE LYASE A

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		3 ALA A  12
GLN A  20
THR A 197
 None
 0.61A 5n0oA-1pe9A:
undetectable		 5n0oA-1pe9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ph5 TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		3 ALA A 448
GLN A 412
THR A 435
 None
 0.74A 5n0oA-1ph5A:
undetectable		 5n0oA-1ph5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pho PHOSPHOPORIN

(Escherichia
coli) 		PF00267
(Porin_1) 		3 ALA A 251
GLN A 255
THR A 234
 None
 0.75A 5n0oA-1phoA:
undetectable		 5n0oA-1phoA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqu ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Haemophilus
influenzae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ALA A  99
GLN A  74
THR A  79
 NAP  A1372 (-3.2A)
NAP  A1372 (-3.0A)
None
 0.63A 5n0oA-1pquA:
undetectable		 5n0oA-1pquA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 ALA A 257
GLN A 279
THR A 273
 None
None
NAG  A 803 (-2.6A)
 0.00A 5n0oA-1q5aA:
undetectable		 5n0oA-1q5aA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5e AVIRULENCE PROTEIN

(Pseudomonas
syringae) 		PF11592
(AvrPto) 		3 ALA A 112
GLN A  77
THR A  79
 None
 0.50A 5n0oA-1r5eA:
undetectable		 5n0oA-1r5eA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6e TYPEIII-SECRETED
PROTEIN EFFECTOR:
INVASION-ASSOCIATED
PROTEIN

(Salmonella
enterica) 		PF07487
(SopE_GEF) 		3 ALA A 147
GLN A 225
THR A 227
 None
 0.71A 5n0oA-1r6eA:
undetectable		 5n0oA-1r6eA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4b ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Escherichia
coli) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ALA A  98
GLN A  73
THR A  78
 None
 0.69A 5n0oA-1t4bA:
undetectable		 5n0oA-1t4bA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Thermotoga
maritima) 		PF01008
(IF-2B) 		3 ALA A 185
GLN A 193
THR A 198
 None
SO4  A 401 (-4.4A)
None
 0.76A 5n0oA-1t9kA:
undetectable		 5n0oA-1t9kA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ALA A 152
GLN A 333
THR A 761
 None
2MD  A 800 (-3.5A)
None
 0.71A 5n0oA-1tmoA:
undetectable		 5n0oA-1tmoA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		3 ALA A 513
GLN A   8
THR A  12
 None
SF4  A1544 (-4.6A)
SF4  A1544 (-3.9A)
 0.70A 5n0oA-1upxA:
undetectable		 5n0oA-1upxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu0 ATP SYNTHASE C CHAIN

(Bacillus sp.
PS3) 		PF00137
(ATP-synt_C) 		3 ALA A  35
GLN A  45
THR A  47
 None
 0.76A 5n0oA-1wu0A:
undetectable		 5n0oA-1wu0A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF02567
(PhzC-PhzF) 		3 ALA A  90
GLN A   9
THR A 286
 None
 0.71A 5n0oA-1ym5A:
undetectable		 5n0oA-1ym5A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major) 		PF01008
(IF-2B) 		3 ALA A 216
GLN A 224
THR A 229
 None
SO4  A 402 (-4.2A)
None
 0.75A 5n0oA-2a0uA:
1.8		 5n0oA-2a0uA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		3 ALA B 273
GLN B 268
THR B 263
 None
 0.74A 5n0oA-2afhB:
2.4		 5n0oA-2afhB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE

(Escherichia
coli) 		PF02734
(Dak2) 		3 ALA A 194
GLN A 167
THR A 169
 None
 0.76A 5n0oA-2btdA:
undetectable		 5n0oA-2btdA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frv PERIPLASMIC
HYDROGENASE

(Desulfovibrio
gigas) 		no annotation 3 ALA L  73
GLN L 221
THR L 223
 None
 0.68A 5n0oA-2frvL:
undetectable		 5n0oA-2frvL:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3b PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		3 ALA A  76
GLN A 137
THR A 139
 None
 0.66A 5n0oA-2g3bA:
undetectable		 5n0oA-2g3bA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus) 		PF01432
(Peptidase_M3) 		3 ALA A 324
GLN A  74
THR A  65
 None
 0.69A 5n0oA-2h1nA:
undetectable		 5n0oA-2h1nA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilu ALDEHYDE
DEHYDROGENASE A

(Escherichia
coli) 		PF00171
(Aldedh) 		3 ALA A 166
GLN A  57
THR A 146
 None
 0.73A 5n0oA-2iluA:
undetectable		 5n0oA-2iluA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ALA A 407
GLN A 380
THR A 382
 None
 0.76A 5n0oA-2jifA:
undetectable		 5n0oA-2jifA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		3 ALA A 511
GLN A 475
THR A 479
 None
GOL  A 755 (-4.9A)
None
 0.66A 5n0oA-2pziA:
undetectable		 5n0oA-2pziA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvp UNCHARACTERIZED
PROTEIN

(Shewanella
amazonensis) 		PF04952
(AstE_AspA) 		3 ALA A 257
GLN A 249
THR A 245
 None
 0.66A 5n0oA-2qvpA:
undetectable		 5n0oA-2qvpA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3c SIGNAL RECOGNITION
54 KDA PROTEIN

(Methanocaldococcus
jannaschii) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		3 ALA C 143
GLN C 109
THR C 114
 None
 0.73A 5n0oA-2v3cC:
undetectable		 5n0oA-2v3cC:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		3 ALA A 110
GLN A 102
THR A  99
 None
 0.68A 5n0oA-2vhlA:
undetectable		 5n0oA-2vhlA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xot AMPHOTERIN-INDUCED
PROTEIN 1

(Mus musculus) 		PF07679
(I-set)
PF13855
(LRR_8) 		3 ALA A 342
GLN A 294
THR A 292
 None
 0.72A 5n0oA-2xotA:
undetectable		 5n0oA-2xotA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynk WZI

(Escherichia
coli) 		PF14052
(Caps_assemb_Wzi) 		3 ALA A 383
GLN A 102
THR A 112
 None
 0.75A 5n0oA-2ynkA:
undetectable		 5n0oA-2ynkA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 3 ALA A 324
GLN A  74
THR A  65
 None
 0.74A 5n0oA-3ahmA:
undetectable		 5n0oA-3ahmA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 ALA B  29
GLN B 229
THR B 231
 None
 0.65A 5n0oA-3amjB:
undetectable		 5n0oA-3amjB:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfg CLASS A
BETA-LACTAMASE SED1

(Citrobacter
sedlakii) 		PF13354
(Beta-lactamase2) 		3 ALA A  77
GLN A 128
THR A 126
 None
 0.61A 5n0oA-3bfgA:
undetectable		 5n0oA-3bfgA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E

(Syntrophus
aciditrophicus) 		PF02663
(FmdE) 		3 ALA A  51
GLN A  64
THR A  67
 None
 0.71A 5n0oA-3d00A:
undetectable		 5n0oA-3d00A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2

(Homo sapiens) 		PF01852
(START) 		3 ALA A 439
GLN A 540
THR A 542
 None
 0.60A 5n0oA-3fo5A:
undetectable		 5n0oA-3fo5A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvd PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		3 ALA A 257
GLN A 485
THR A 488
 None
 0.54A 5n0oA-3hvdA:
undetectable		 5n0oA-3hvdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieh PUTATIVE
METALLOPEPTIDASE

(Shewanella
baltica) 		PF04952
(AstE_AspA) 		3 ALA A 258
GLN A 250
THR A 246
 None
PGE  A 288 ( 3.5A)
None
 0.61A 5n0oA-3iehA:
undetectable		 5n0oA-3iehA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik5 PROTEIN NEF

(Simian
immunodeficiency
virus) 		PF00469
(F-protein) 		3 ALA A 116
GLN A 157
THR A 170
 ALA  A 116 ( 0.0A)
GLN  A 157 ( 0.6A)
THR  A 170 ( 0.8A)
 0.57A 5n0oA-3ik5A:
undetectable		 5n0oA-3ik5A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvy URIDINE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		3 ALA A 250
GLN A 156
THR A 154
 None
 0.76A 5n0oA-3kvyA:
undetectable		 5n0oA-3kvyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l57 MOBILIZATION PROTEIN
TRAI

(Escherichia
coli) 		PF08751
(TrwC) 		3 ALA A 206
GLN A  96
THR A 104
 EDO  A 306 ( 3.8A)
None
EDO  A 305 (-4.3A)
 0.69A 5n0oA-3l57A:
undetectable		 5n0oA-3l57A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum) 		PF13458
(Peripla_BP_6) 		3 ALA A 118
GLN A  86
THR A  91
 None
 0.68A 5n0oA-3lopA:
3.6		 5n0oA-3lopA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		3 ALA A 216
GLN A 124
THR A  52
 None
 0.73A 5n0oA-3pgxA:
1.9		 5n0oA-3pgxA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ALA A  97
GLN A  72
THR A  77
 None
NAP  A 372 (-3.6A)
None
 0.64A 5n0oA-3pzrA:
undetectable		 5n0oA-3pzrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 ALA A 684
GLN A 670
THR A 691
 None
 0.69A 5n0oA-3s29A:
undetectable		 5n0oA-3s29A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		3 ALA A 257
GLN A 485
THR A 488
 None
 0.53A 5n0oA-3texA:
undetectable		 5n0oA-3texA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Burkholderia
thailandensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ALA A  97
GLN A  72
THR A  77
 None
 0.58A 5n0oA-3uw3A:
undetectable		 5n0oA-3uw3A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N) 		3 ALA A 375
GLN A 283
THR A 285
 None
 0.72A 5n0oA-3v7iA:
undetectable		 5n0oA-3v7iA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vjz PUTATIVE
UNCHARACTERIZED
PROTEIN

(Neisseria
meningitidis) 		PF14300
(DUF4375) 		3 ALA A  31
GLN A  45
THR A  49
 None
 0.57A 5n0oA-3vjzA:
undetectable		 5n0oA-3vjzA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3

(Homo sapiens) 		PF01825
(GPS)
PF02793
(HRM)
PF16489
(GAIN) 		3 ALA A 811
GLN A 865
THR A 814
 None
 0.66A 5n0oA-4dloA:
undetectable		 5n0oA-4dloA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4en2 PROTEIN NEF

(Human
immunodeficiency
virus 1) 		PF00469
(F-protein) 		3 ALA B  84
GLN B 125
THR B 138
 None
 0.73A 5n0oA-4en2B:
undetectable		 5n0oA-4en2B:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqb SPERMIDINE/PUTRESCIN
E ABC SUPERFAMILY
ATP BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		3 ALA A 279
GLN A  35
THR A  58
 None
 0.51A 5n0oA-4eqbA:
undetectable		 5n0oA-4eqbA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA

(Rattus
norvegicus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 ALA A 166
GLN A  99
THR A 101
 None
 0.68A 5n0oA-4grvA:
undetectable		 5n0oA-4grvA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1f E3 UBIQUITIN-PROTEIN
LIGASE PARKIN

(Homo sapiens) 		PF01485
(IBR) 		3 ALA A 390
GLN A 276
THR A 270
 None
 0.70A 5n0oA-4i1fA:
undetectable		 5n0oA-4i1fA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ALA A  64
GLN A  31
THR A  33
 None
IOD  A 404 ( 4.4A)
None
 0.70A 5n0oA-4izgA:
undetectable		 5n0oA-4izgA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE

(Pseudoalteromonas
atlantica) 		PF00348
(polyprenyl_synt) 		3 ALA A  56
GLN A  62
THR A 186
 None
 0.58A 5n0oA-4jxyA:
undetectable		 5n0oA-4jxyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Haemophilus
influenzae) 		PF01380
(SIS) 		3 ALA A 259
GLN A 250
THR A 252
 None
 0.75A 5n0oA-4m0dA:
undetectable		 5n0oA-4m0dA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9c BACTERIAL
TRANSFERASE
HEXAPEPTIDE (THREE
REPEATS) FAMILY
PROTEIN

(Acinetobacter
baumannii) 		PF00132
(Hexapep) 		3 ALA A 130
GLN A  94
THR A 116
 None
 0.71A 5n0oA-4m9cA:
2.1		 5n0oA-4m9cA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN

(Thermomonospora
curvata) 		PF13458
(Peripla_BP_6) 		3 ALA A 254
GLN A 279
THR A 283
 None
 0.73A 5n0oA-4n03A:
undetectable		 5n0oA-4n03A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqf NUCLEOTIDYLTRANSFERA
SE

(Agrobacterium
fabrum) 		PF05168
(HEPN) 		3 ALA A 197
GLN A 275
THR A 278
 None
 0.74A 5n0oA-4nqfA:
undetectable		 5n0oA-4nqfA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsd CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13833
(EF-hand_8) 		3 ALA A 380
GLN A 398
THR A 402
 None
 0.73A 5n0oA-4nsdA:
undetectable		 5n0oA-4nsdA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Deinococcus
radiodurans) 		PF02540
(NAD_synthase) 		3 ALA A 207
GLN A  58
THR A  61
 None
 0.67A 5n0oA-4q16A:
undetectable		 5n0oA-4q16A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r72 ABC-TYPE FE3+
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Actinobacillus
pleuropneumoniae) 		PF13343
(SBP_bac_6) 		3 ALA A  18
GLN A 258
THR A 260
 None
 0.74A 5n0oA-4r72A:
undetectable		 5n0oA-4r72A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		3 ALA L  89
GLN L 237
THR L 239
 None
F3S  S2003 (-3.4A)
None
 0.64A 5n0oA-4u9iL:
undetectable		 5n0oA-4u9iL:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
fructosivorans) 		PF00374
(NiFeSe_Hases) 		3 ALA Q  80
GLN Q 230
THR Q 232
 None
 0.66A 5n0oA-4upeQ:
undetectable		 5n0oA-4upeQ:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Francisella
tularensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ALA A  98
GLN A  73
THR A  78
 None
 0.67A 5n0oA-4wojA:
undetectable		 5n0oA-4wojA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		no annotation 3 ALA C  98
GLN C  73
THR C  78
 NAP  C 500 ( 4.0A)
NAP  C 500 (-3.2A)
None
 0.59A 5n0oA-5bntC:
undetectable		 5n0oA-5bntC:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 3 ALA A 429
GLN A 226
THR A 229
 None
 0.72A 5n0oA-5c2vA:
undetectable		 5n0oA-5c2vA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3l NUP54
NUCLEOPORIN NUP58

(Xenopus laevis;
Xenopus laevis) 		PF13874
(Nup54)
PF15967
(Nucleoporin_FG2) 		3 ALA B 313
GLN A 368
THR A 372
 None
 0.76A 5n0oA-5c3lB:
undetectable		 5n0oA-5c3lB:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce5 TRIACYLGLYCEROL
LIPASE

(Geobacillus
thermocatenulatus) 		no annotation 3 ALA A 112
GLN A 115
THR A 164
 None
 0.76A 5n0oA-5ce5A:
undetectable		 5n0oA-5ce5A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da8 60 KDA CHAPERONIN

(Chlorobaculum
tepidum) 		PF00118
(Cpn60_TCP1) 		3 ALA A 111
GLN A 436
THR A 438
 None
 0.75A 5n0oA-5da8A:
undetectable		 5n0oA-5da8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 ALA A 620
GLN A 571
THR A 574
 None
 0.66A 5n0oA-5dllA:
undetectable		 5n0oA-5dllA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		3 ALA A 339
GLN A 123
THR A 127
 None
 0.75A 5n0oA-5ecoA:
undetectable		 5n0oA-5ecoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		3 ALA A 100
GLN A  72
THR A  74
 None
 0.75A 5n0oA-5ey8A:
undetectable		 5n0oA-5ey8A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		3 ALA b 569
GLN b 492
THR b 496
 None
 0.74A 5n0oA-5l9wb:
2.8		 5n0oA-5l9wb:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE

(Shewanella
oneidensis) 		PF03060
(NMO) 		3 ALA A  35
GLN A  17
THR A 340
 None
 0.69A 5n0oA-5lsmA:
undetectable		 5n0oA-5lsmA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT
POTASSIUM-TRANSPORTI
NG ATPASE KDPC
SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF03814
(KdpA)
PF02669
(KdpC) 		3 ALA A 220
GLN C  31
THR C  26
 None
 0.74A 5n0oA-5mrwA:
undetectable		 5n0oA-5mrwA:
22.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n0o PEPTIDE
N-METHYLTRANSFERASE

(Omphalotus
olearius) 		no annotation 3 ALA A 130
GLN A 172
THR A 245
 SAM  A 501 (-3.2A)
HSE  A 504 ( 3.3A)
SAM  A 501 (-3.6A)
 0.04A 5n0oA-5n0oA:
50.1		 5n0oA-5n0oA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nuh PROTEIN NEF

(Simian
immunodeficiency
virus) 		PF00469
(F-protein) 		3 ALA A 116
GLN A 157
THR A 170
 None
 0.59A 5n0oA-5nuhA:
undetectable		 5n0oA-5nuhA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu0 LMO2125 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		3 ALA A 249
GLN A 244
THR A 190
 None
 0.70A 5n0oA-5tu0A:
undetectable		 5n0oA-5tu0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2w SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		3 ALA A  74
GLN A  62
THR A  36
 None
 0.75A 5n0oA-5u2wA:
2.1		 5n0oA-5u2wA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5g BETA-LACTAMASE

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		3 ALA A 154
GLN A 166
THR A 168
 None
NA  A 304 (-4.2A)
None
 0.67A 5n0oA-5x5gA:
undetectable		 5n0oA-5x5gA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 3 ALA A 607
GLN A 450
THR A 452
 None
 0.75A 5n0oA-5z9sA:
1.6		 5n0oA-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b72 PROTEIN NEF

(Human
immunodeficiency
virus 1) 		no annotation 3 ALA A  84
GLN A 125
THR A 138
 None
 0.75A 5n0oA-6b72A:
undetectable		 5n0oA-6b72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		no annotation 3 ALA A  98
GLN A  73
THR A  78
 EDO  A 406 ( 4.2A)
SO4  A 401 (-3.7A)
None
 0.63A 5n0oA-6bacA:
undetectable		 5n0oA-6bacA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Enterococcus
faecalis) 		no annotation 3 ALA A 202
GLN A  52
THR A  55
 None
 0.69A 5n0oA-6c8qA:
undetectable		 5n0oA-6c8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4

(Homo sapiens) 		no annotation 3 ALA A 974
GLN A 904
THR A 906
 None
 0.71A 5n0oA-6c90A:
1.8		 5n0oA-6c90A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME RNA HELICASE
MTR4

(Homo sapiens) 		no annotation 3 ALA M 974
GLN M 904
THR M 906
 None
 0.47A 5n0oA-6d6qM:
1.3		 5n0oA-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbg OUTER MEMBRANE
PROTEIN

(Helicobacter
pylori) 		no annotation 3 ALA A  79
GLN A 333
THR A 294
 None
 0.76A 5n0oA-6gbgA:
undetectable		 5n0oA-6gbgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbh HOPQ

(Helicobacter
pylori) 		no annotation 3 ALA C  83
GLN C 330
THR C 292
 None
 0.70A 5n0oA-6gbhC:
undetectable		 5n0oA-6gbhC:
undetectable