SIMILAR PATTERNS OF AMINO ACIDS FOR 5MZR_E_PFLE409_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amu GRAMICIDIN
SYNTHETASE 1

(Brevibacillus
brevis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 TYR A 116
ILE A  94
TYR A 189
ILE A 131
 None
 0.88A 5mzrE-1amuA:
0.0		 5mzrE-1amuA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)

(Bacillus
subtilis) 		PF01467
(CTP_transf_like) 		4 TYR A  52
ILE A  35
VAL A  68
ILE A  58
 None
 0.85A 5mzrE-1cozA:
undetectable		 5mzrE-1cozA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1di0 LUMAZINE SYNTHASE

(Brucella
abortus) 		PF00885
(DMRL_synthase) 		4 PRO A  60
ILE A  97
VAL A 115
TYR A  57
 None
 0.86A 5mzrE-1di0A:
2.6		 5mzrE-1di0A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 TYR A 511
TYR A 507
ILE A 490
ILE A 468
 None
 0.75A 5mzrE-1fprA:
0.0		 5mzrE-1fprA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpw CALCIUM-BINDING
PROTEIN NCS-1

(Saccharomyces
cerevisiae) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 TYR A 129
VAL A 149
TYR A 186
ILE A 124
 None
 0.84A 5mzrE-1fpwA:
undetectable		 5mzrE-1fpwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2u 20 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		4 TYR X  57
ILE X  56
VAL X  86
ILE X 101
 None
 0.90A 5mzrE-1h2uX:
undetectable		 5mzrE-1h2uX:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hrd GLUTAMATE
DEHYDROGENASE

([Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 PRO A 309
ILE A 317
VAL A 314
THR A 258
 None
 0.96A 5mzrE-1hrdA:
undetectable		 5mzrE-1hrdA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1irx LYSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01921
(tRNA-synt_1f) 		4 PRO A 311
ILE A   8
THR A  44
ILE A  47
 None
 0.81A 5mzrE-1irxA:
0.0		 5mzrE-1irxA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nye OSMOTICALLY
INDUCIBLE PROTEIN C

(Escherichia
coli) 		PF02566
(OsmC) 		4 ILE A 129
VAL A 126
TYR A 159
ILE A 138
 None
 0.90A 5mzrE-1nyeA:
undetectable		 5mzrE-1nyeA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r75 HYPOTHETICAL PROTEIN

(Leishmania
major) 		PF09149
(DUF1935) 		4 TYR A  35
PRO A  28
TYR A  27
THR A  26
 None
 0.97A 5mzrE-1r75A:
undetectable		 5mzrE-1r75A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ti8 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 TYR A 148
PRO A  73
THR A  71
ILE A  70
 None
 0.94A 5mzrE-1ti8A:
undetectable		 5mzrE-1ti8A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tza APAG PROTEIN

(Shewanella
oneidensis) 		PF04379
(DUF525) 		4 ILE A  52
TYR A 100
THR A  99
ILE A 114
 ILE  A  52 ( 0.4A)
TYR  A 100 ( 1.3A)
THR  A  99 ( 0.8A)
ILE  A 114 ( 0.6A)
 0.70A 5mzrE-1tzaA:
3.3		 5mzrE-1tzaA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		4 ILE A 207
VAL A 340
THR A 128
ILE A 131
 None
 0.88A 5mzrE-1vgmA:
undetectable		 5mzrE-1vgmA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9z VP9

(Banna virus) 		PF08978
(Reoviridae_Vp9) 		4 TYR A 148
TYR A 116
THR A 115
ILE A 114
 None
 0.91A 5mzrE-1w9zA:
undetectable		 5mzrE-1w9zA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ILE A 449
VAL A 487
THR A 481
ILE A 480
 None
 0.90A 5mzrE-1xfdA:
undetectable		 5mzrE-1xfdA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq4 PROTEIN APAG

(Bordetella
pertussis) 		PF04379
(DUF525) 		4 ILE A  57
TYR A 105
THR A 104
ILE A 119
 None
None
PO4  A 401 (-3.2A)
None
 0.80A 5mzrE-1xq4A:
3.1		 5mzrE-1xq4A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzz INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Mus musculus) 		PF08709
(Ins145_P3_rec) 		4 TYR A 117
ILE A 220
VAL A 182
ILE A 121
 None
 0.86A 5mzrE-1xzzA:
undetectable		 5mzrE-1xzzA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		4 TYR A 509
TYR A 505
ILE A 488
ILE A 466
 None
 0.87A 5mzrE-2b3oA:
undetectable		 5mzrE-2b3oA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ILE A 374
VAL A 404
THR A 398
ILE A 397
 SO4  A1768 (-4.9A)
None
None
None
 0.86A 5mzrE-2bucA:
undetectable		 5mzrE-2bucA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbp CUCUMBER BASIC
PROTEIN

(Cucumis sativus) 		PF02298
(Cu_bind_like) 		4 ILE A  91
VAL A   5
TYR A  61
ILE A  68
 None
 0.95A 5mzrE-2cbpA:
undetectable		 5mzrE-2cbpA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 PRO A 213
ILE A 243
TYR A 176
THR A 177
 None
 0.86A 5mzrE-2cgjA:
undetectable		 5mzrE-2cgjA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw1 SN4M

(-) 		no annotation 4 TYR A  53
PRO A  62
THR A  60
ILE A  59
 None
 0.96A 5mzrE-2cw1A:
undetectable		 5mzrE-2cw1A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7y TRNASE Z

(Thermotoga
maritima) 		PF12706
(Lactamase_B_2) 		4 VAL A 106
TYR A  89
THR A  90
ILE A  93
 None
 0.73A 5mzrE-2e7yA:
undetectable		 5mzrE-2e7yA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ILE A 374
VAL A 404
THR A 398
ILE A 397
 None
 0.83A 5mzrE-2g5tA:
undetectable		 5mzrE-2g5tA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grg YNR034W-AP
HYPOTHETICAL PROTEIN

(Saccharomyces
cerevisiae) 		PF11503
(DUF3215) 		4 ILE A   5
VAL A  10
THR A  81
ILE A  66
 None
 0.96A 5mzrE-2grgA:
undetectable		 5mzrE-2grgA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k53 A3DK08 PROTEIN

(Ruminiclostridium
thermocellum) 		PF08984
(DUF1858) 		4 ILE A   3
VAL A  12
THR A  19
ILE A  22
 None
 0.71A 5mzrE-2k53A:
undetectable		 5mzrE-2k53A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ILE A 372
VAL A 405
THR A 399
ILE A 398
 None
 0.85A 5mzrE-2oaeA:
undetectable		 5mzrE-2oaeA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1

(Mesorhizobium
loti) 		PF00885
(DMRL_synthase) 		4 PRO A  59
ILE A  96
VAL A 114
TYR A  56
 None
None
None
INI  A 201 (-4.7A)
 0.85A 5mzrE-2obxA:
2.4		 5mzrE-2obxA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfc PLCR PROTEIN

(Bacillus
thuringiensis) 		PF01381
(HTH_3) 		4 ILE A 225
VAL A 196
TYR A 239
ILE A 235
 None
 0.85A 5mzrE-2qfcA:
3.6		 5mzrE-2qfcA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF00293
(NUDIX)
PF01467
(CTP_transf_like) 		4 ILE A   9
VAL A 106
THR A 100
ILE A  99
 None
 0.97A 5mzrE-2qjoA:
undetectable		 5mzrE-2qjoA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B

(Saccharomyces
cerevisiae) 		PF16846
(Cep3) 		4 ILE A 407
VAL A 384
TYR A 345
ILE A 402
 None
 0.83A 5mzrE-2quqA:
5.1		 5mzrE-2quqA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5g YSCU

(Yersinia
enterocolitica) 		PF01312
(Bac_export_2) 		4 TYR A 287
ILE A 298
VAL A 254
ILE A 306
 None
 0.93A 5mzrE-2v5gA:
undetectable		 5mzrE-2v5gA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp1 PERIPLASMIC
IRON-BINDING PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		4 TYR A 124
ILE A 279
VAL A 103
ILE A  82
 None
 0.96A 5mzrE-2vp1A:
undetectable		 5mzrE-2vp1A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 TYR A 753
ILE A 808
THR A 763
ILE A 783
 None
 0.95A 5mzrE-2vsqA:
undetectable		 5mzrE-2vsqA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 PRO A 195
TYR A 331
THR A 232
ILE A 305
 None
 0.87A 5mzrE-2xtlA:
2.3		 5mzrE-2xtlA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT

(Thermus
thermophilus) 		PF00344
(SecY) 		4 TYR Y  80
ILE Y  81
THR Y 184
ILE Y 187
 None
 0.91A 5mzrE-2zqpY:
undetectable		 5mzrE-2zqpY:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs4 UNCHARACTERIZED
PROTEIN PH0321

(Pyrococcus
horikoshii) 		no annotation 4 PRO A 247
TYR A  39
ILE A  40
TYR A 240
 None
 0.55A 5mzrE-3bs4A:
undetectable		 5mzrE-3bs4A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		4 PRO A 334
TYR A 333
THR A 332
ILE A 331
 TAD  A 500 (-4.6A)
TAD  A 500 (-4.4A)
None
None
 0.71A 5mzrE-3buzA:
undetectable		 5mzrE-3buzA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv8 TETRAHYDRODIPICOLINA
TE ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF08503
(DapH_N) 		4 PRO A  37
TYR A  36
THR A  35
ILE A  34
 None
 0.84A 5mzrE-3bv8A:
undetectable		 5mzrE-3bv8A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwt PROTEIN PUF4

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		4 TYR A 775
VAL A 811
THR A 778
ILE A 781
 None
 0.88A 5mzrE-3bwtA:
undetectable		 5mzrE-3bwtA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1

(Cavia porcellus) 		PF00106
(adh_short) 		4 PRO A 178
TYR A 177
THR A 176
ILE A 175
 None
GOL  A   9 ( 4.6A)
None
None
 0.92A 5mzrE-3dwfA:
undetectable		 5mzrE-3dwfA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emj INORGANIC
PYROPHOSPHATASE

(Rickettsia
prowazekii) 		PF00719
(Pyrophosphatase) 		4 PRO A  59
ILE A  15
THR A  61
ILE A 169
 None
 0.95A 5mzrE-3emjA:
undetectable		 5mzrE-3emjA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Burkholderia
pseudomallei) 		PF00698
(Acyl_transf_1) 		4 ILE A 261
VAL A 269
THR A 282
ILE A 285
 None
 0.91A 5mzrE-3ezoA:
undetectable		 5mzrE-3ezoA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		4 TYR A 510
ILE A 513
VAL A 489
ILE A 446
 None
 0.76A 5mzrE-3f6tA:
undetectable		 5mzrE-3f6tA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdf PROBABLE
NADP-DEPENDENT
MANNITOL
DEHYDROGENASE

(Cladosporium
herbarum) 		PF13561
(adh_short_C2) 		4 ILE A  51
VAL A  49
TYR A 242
ILE A 106
 None
 0.87A 5mzrE-3gdfA:
undetectable		 5mzrE-3gdfA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h33 CYTOCHROME C7

(Geobacter
sulfurreducens) 		PF02085
(Cytochrom_CIII) 		4 PRO A   7
TYR A   6
THR A   5
ILE A   4
 None
HEM  A  77 ( 4.3A)
None
None
 0.85A 5mzrE-3h33A:
undetectable		 5mzrE-3h33A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 412
ILE A 423
THR A 431
ILE A 432
 None
 0.83A 5mzrE-3i4gA:
4.2		 5mzrE-3i4gA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg7 CURH

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		4 ILE A1135
VAL A 982
THR A1139
ILE A1195
 None
 0.93A 5mzrE-3kg7A:
undetectable		 5mzrE-3kg7A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		4 ILE A 533
VAL A 560
THR A 543
ILE A 518
 None
 0.94A 5mzrE-3la4A:
undetectable		 5mzrE-3la4A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mda DNA POLYMERASE
LAMBDA

(Homo sapiens) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 TYR A 496
PRO A 435
THR A 433
ILE A 432
 None
 0.74A 5mzrE-3mdaA:
undetectable		 5mzrE-3mdaA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfv ALGINATE LYASE

(Bacteroides
ovatus) 		PF05426
(Alginate_lyase) 		4 TYR A 187
ILE A 309
THR A 190
ILE A 193
 None
 0.93A 5mzrE-3nfvA:
undetectable		 5mzrE-3nfvA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3d NUCLEOPORIN 53

(Meyerozyma
guilliermondii) 		PF05172
(Nup35_RRM) 		4 VAL A 314
TYR A 327
THR A 326
ILE A 325
 None
 0.93A 5mzrE-3p3dA:
undetectable		 5mzrE-3p3dA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 4 TYR A 285
VAL A 263
TYR A 290
ILE A 306
 None
 0.92A 5mzrE-3p4gA:
undetectable		 5mzrE-3p4gA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		4 TYR A 509
TYR A 505
ILE A 488
ILE A 466
 None
 0.88A 5mzrE-3ps5A:
undetectable		 5mzrE-3ps5A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 PRO A 401
TYR A 400
THR A 399
ILE A 398
 None
 0.94A 5mzrE-3ps9A:
undetectable		 5mzrE-3ps9A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwv MHC CLASS I ANTIGEN

(Bos taurus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A   8
TYR A  66
ILE A  65
ILE A  72
 None
 0.92A 5mzrE-3pwvA:
undetectable		 5mzrE-3pwvA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q94 FRUCTOSE-BISPHOSPHAT
E ALDOLASE, CLASS II

(Bacillus
anthracis) 		PF01116
(F_bP_aldolase) 		4 ILE A  82
VAL A  67
THR A  31
ILE A  34
 None
 0.69A 5mzrE-3q94A:
undetectable		 5mzrE-3q94A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdh FIMBRIAL STRUCTURAL
SUBUNIT

(Actinomyces
naeslundii) 		PF16569
(GramPos_pilinBB) 		4 TYR A 239
ILE A 202
TYR A 241
ILE A 324
 None
 0.69A 5mzrE-3qdhA:
3.1		 5mzrE-3qdhA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
phage 201phi2-1) 		PF00091
(Tubulin) 		4 TYR A 161
ILE A 164
VAL A 118
THR A  13
 GDP  A 400 (-3.7A)
GDP  A 400 (-3.7A)
GDP  A 400 (-4.6A)
GDP  A 400 (-3.5A)
 0.83A 5mzrE-3r4vA:
undetectable		 5mzrE-3r4vA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE

(Gloydius
saxatilis) 		PF00089
(Trypsin) 		4 PRO A 149
TYR A 153
TYR A 148
THR A 147
 None
 0.90A 5mzrE-3s69A:
undetectable		 5mzrE-3s69A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8s INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Rattus
norvegicus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 TYR A 117
ILE A 220
VAL A 182
ILE A 121
 None
 0.90A 5mzrE-3t8sA:
3.1		 5mzrE-3t8sA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzw POLYKETIDE SYNTHASE
PKS13

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		4 ILE A 781
VAL A 744
THR A 820
ILE A 823
 None
 0.95A 5mzrE-3tzwA:
undetectable		 5mzrE-3tzwA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf4 TYROSINE-PROTEIN
KINASE FYN, ISOFORM
2

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1) 		4 TYR A 213
TYR A 185
ILE A 175
ILE A 215
 None
 0.94A 5mzrE-3uf4A:
undetectable		 5mzrE-3uf4A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a34 RBSD/FUCU TRANSPORT
PROTEIN FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF05025
(RbsD_FucU) 		4 ILE A 134
TYR A 105
THR A 104
ILE A 103
 None
 0.83A 5mzrE-4a34A:
undetectable		 5mzrE-4a34A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7l MYOSIN IE HEAVY
CHAIN

(Dictyostelium
discoideum) 		PF00063
(Myosin_head) 		4 TYR C 630
ILE C 670
THR C 656
ILE C 659
 None
 0.83A 5mzrE-4a7lC:
2.2		 5mzrE-4a7lC:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 TYR A 536
ILE A 343
TYR A 516
ILE A 391
 None
 0.82A 5mzrE-4d8mA:
5.3		 5mzrE-4d8mA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Francisella
tularensis) 		PF00155
(Aminotran_1_2) 		4 TYR A 119
ILE A 342
VAL A 296
ILE A 303
 None
 0.95A 5mzrE-4iw7A:
undetectable		 5mzrE-4iw7A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA) 		4 PRO A 197
TYR A 196
THR A 195
ILE A 194
 None
 0.88A 5mzrE-4mioA:
undetectable		 5mzrE-4mioA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6i NUCLEOPROTEIN

(Lymphocytic
choriomeningitis
mammarenavirus) 		PF17290
(Arena_ncap_C) 		4 ILE A 404
VAL A 442
TYR A 407
ILE A 549
 None
 0.74A 5mzrE-4o6iA:
undetectable		 5mzrE-4o6iA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oz5 BACILLUS SUBTILIS
HMOB

(Bacillus
subtilis) 		PF03992
(ABM) 		4 ILE A  25
TYR A   7
THR A   6
ILE A   5
 None
 0.92A 5mzrE-4oz5A:
undetectable		 5mzrE-4oz5A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio cholerae) 		PF04205
(FMN_bind) 		4 ILE C 137
VAL C  52
TYR C 167
THR C 166
 None
 0.95A 5mzrE-4p6vC:
undetectable		 5mzrE-4p6vC:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADB

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas) 		4 ILE B 131
VAL B  91
TYR B  20
ILE B  65
 None
 0.96A 5mzrE-4rltB:
undetectable		 5mzrE-4rltB:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II

(Staphylococcus
aureus) 		PF01116
(F_bP_aldolase) 		4 ILE A  82
VAL A  67
THR A  31
ILE A  34
 None
 0.64A 5mzrE-4to8A:
undetectable		 5mzrE-4to8A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa7 NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio harveyi) 		PF04205
(FMN_bind) 		4 ILE A 141
TYR A 171
THR A 170
ILE A 169
 None
 0.72A 5mzrE-4xa7A:
undetectable		 5mzrE-4xa7A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00632
(HECT) 		4 ILE A 608
VAL A 571
THR A 624
ILE A 622
 None
 0.72A 5mzrE-4y07A:
undetectable		 5mzrE-4y07A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		4 ILE A 208
TYR A 261
THR A 262
ILE A 265
 None
 0.55A 5mzrE-4yeuA:
19.7		 5mzrE-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		4 PRO A 120
ILE A 208
THR A 262
ILE A 265
 None
 0.83A 5mzrE-4yeuA:
19.7		 5mzrE-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)

(Agrobacterium
fabrum) 		PF00496
(SBP_bac_5) 		4 TYR A 255
TYR A 237
THR A 236
ILE A 235
 None
 0.78A 5mzrE-4ze8A:
undetectable		 5mzrE-4ze8A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqg 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Moraxella
catarrhalis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 ILE A 152
VAL A 101
THR A  21
ILE A  24
 None
 0.90A 5mzrE-4zqgA:
undetectable		 5mzrE-4zqgA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Escherichia
virus T4;
Homo sapiens;
Mus musculus) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		4 PRO A  53
ILE A  48
VAL A  87
ILE A 300
 None
 0.85A 5mzrE-4zwjA:
3.6		 5mzrE-4zwjA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdc VP1, STRUCTURAL
POLYPROTEIN

(Israeli acute
paralysis virus) 		PF08762
(CRPV_capsid) 		4 PRO A 135
TYR A 134
THR A 133
ILE A 132
 None
 0.80A 5mzrE-5cdcA:
undetectable		 5mzrE-5cdcA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ctm BETA-LACTAMASE

(Bacillus
pumilus) 		PF00905
(Transpeptidase) 		4 TYR A 249
ILE A 253
THR A 277
ILE A 280
 None
 0.88A 5mzrE-5ctmA:
undetectable		 5mzrE-5ctmA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dp2 CURF

(Lyngbya
majuscula) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 PRO A 104
ILE A  38
VAL A  36
ILE A 100
 None
 0.81A 5mzrE-5dp2A:
undetectable		 5mzrE-5dp2A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es6 LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00551
(Formyl_trans_N) 		4 TYR A 481
ILE A 533
THR A 491
ILE A 508
 None
 0.90A 5mzrE-5es6A:
undetectable		 5mzrE-5es6A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezb CHICKEN PRESTIN STAS
DOMAIN,CHICKEN
PRESTIN STAS DOMAIN

(Gallus gallus) 		PF01740
(STAS) 		4 TYR A 526
TYR A 538
ILE A 541
ILE A 516
 None
 0.78A 5mzrE-5ezbA:
undetectable		 5mzrE-5ezbA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g37 41.9 KDA
INSECTICIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		4 ILE A 256
VAL A 258
THR A 272
ILE A 275
 None
 0.92A 5mzrE-5g37A:
undetectable		 5mzrE-5g37A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyk MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Saccharomyces
cerevisiae) 		PF10296
(MMM1) 		4 PRO A  62
ILE A 167
THR A  60
ILE A  59
 None
 0.94A 5mzrE-5gykA:
undetectable		 5mzrE-5gykA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gza PROTEIN O-MANNOSE
KINASE

(Danio rerio) 		PF07714
(Pkinase_Tyr) 		4 PRO A 283
TYR A 307
ILE A 306
VAL A 324
 None
 0.94A 5mzrE-5gzaA:
undetectable		 5mzrE-5gzaA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		4 TYR A 515
TYR A 511
ILE A 494
ILE A 472
 None
 0.91A 5mzrE-5i6vA:
undetectable		 5mzrE-5i6vA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		no annotation 4 TYR C 481
ILE C 533
THR C 491
ILE C 508
 None
 0.96A 5mzrE-5jnfC:
undetectable		 5mzrE-5jnfC:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2

(Rhinovirus C) 		PF00073
(Rhv) 		4 PRO C 190
ILE C 209
VAL A 233
ILE C 127
 None
 0.92A 5mzrE-5k0uC:
undetectable		 5mzrE-5k0uC:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ILE A 218
TYR A 909
THR A 908
ILE A 907
 None
 0.94A 5mzrE-5n0cA:
3.1		 5mzrE-5n0cA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00397
(WW)
PF00632
(HECT) 		4 ILE A 608
VAL A 571
THR A 624
ILE A 622
 None
 0.79A 5mzrE-5tj7A:
2.7		 5mzrE-5tj7A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui5 RNA POLYMERASE SIGMA
FACTOR RPON

(Aquifex
aeolicus) 		PF04552
(Sigma54_DBD)
PF04963
(Sigma54_CBD) 		4 ILE I 347
VAL I 381
TYR I 360
ILE I 368
 None
 0.70A 5mzrE-5ui5I:
2.2		 5mzrE-5ui5I:
14.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 8 TYR C 119
PRO C 120
TYR C 197
ILE C 201
VAL C 242
TYR C 254
THR C 255
ILE C 258
 None
 0.57A 5mzrE-5v6nC:
35.9		 5mzrE-5v6nC:
97.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA

(Haemophilus
influenzae) 		PF04348
(LppC) 		4 ILE A 289
VAL A 256
THR A 315
ILE A 313
 None
 0.94A 5mzrE-5vatA:
2.2		 5mzrE-5vatA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 4 ILE A 162
VAL A 132
TYR A 192
ILE A 218
 None
 0.82A 5mzrE-5w5jA:
undetectable		 5mzrE-5w5jA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xuo POLYKETIDE SYNTHASE
PKS13

(Mycobacterium
tuberculosis) 		no annotation 4 ILE A 781
VAL A 744
THR A 820
ILE A 823
 None
 0.90A 5mzrE-5xuoA:
2.2		 5mzrE-5xuoA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et5 LIGHT-HARVESTING
PROTEIN B-1015 BETA
CHAIN
LIGHT-HARVESTING
PROTEIN B-1015 GAMMA
CHAIN

(Blastochloris
viridis) 		no annotation 4 PRO 2  27
ILE 2  23
THR 1  32
ILE 1  35
 None
BCB  z 101 (-3.7A)
BCB  z 101 ( 3.7A)
None
 0.95A 5mzrE-6et52:
undetectable		 5mzrE-6et52:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 4 TYR B 555
ILE B 552
THR B 527
ILE B 530
 None
 0.74A 5mzrE-6evjB:
undetectable		 5mzrE-6evjB:
22.73