SIMILAR PATTERNS OF AMINO ACIDS FOR 5MZR_D_PFLD410_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dq3 | ENDONUCLEASE (Pyrococcusfuriosus) |
PF09061(Stirrup)PF09062(Endonuc_subdom)PF14528(LAGLIDADG_3)PF14890(Intein_splicing) | 5 | TYR A 194ILE A 205ILE A 182TYR A 216ILE A 146 | None | 1.24A | 5mzrD-1dq3A:0.0 | 5mzrD-1dq3A:10.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6v | METHYL-COENZYME MREDUCTASE I GAMMASUBUNIT (Methanopyruskandleri) |
PF02240(MCR_gamma) | 5 | TYR C 22ILE C 100ILE C 104THR C 218ILE C 220 | None | 1.44A | 5mzrD-1e6vC:0.0 | 5mzrD-1e6vC:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k7j | PROTEIN YCIO (Escherichiacoli) |
PF01300(Sua5_yciO_yrdC) | 5 | TYR A 32ILE A 30ILE A 172VAL A 24ILE A 17 | None | 1.28A | 5mzrD-1k7jA:0.0 | 5mzrD-1k7jA:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1o | REPLICATION PROTEINA 32 KDA SUBUNIT (Homo sapiens) |
no annotation | 5 | ILE B 94VAL B 120TYR B 125THR B 124ILE B 79 | None | 1.36A | 5mzrD-1l1oB:0.0 | 5mzrD-1l1oB:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nvj | MOLYBDOPTERINCONVERTING FACTORSUBUNIT 2 (Escherichiacoli) |
PF02391(MoaE) | 5 | PRO A 56ILE A 85VAL A 8TYR A 55THR A 59 | None | 1.49A | 5mzrD-1nvjA:0.0 | 5mzrD-1nvjA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1o | CELL DIVISIONCONTROL PROTEIN 24 (Saccharomycescerevisiae) |
PF00564(PB1) | 5 | TYR A 854ILE A 816ILE A 813TYR A 768ILE A 802 | None | 1.35A | 5mzrD-1q1oA:0.0 | 5mzrD-1q1oA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qva | INITIATION FACTOR 4A (Saccharomycescerevisiae) |
PF00270(DEAD) | 5 | PRO A 54TYR A 16ILE A 221VAL A 19ILE A 47 | None | 1.28A | 5mzrD-1qvaA:undetectable | 5mzrD-1qvaA:14.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sgw | PUTATIVE ABCTRANSPORTER (Pyrococcusfuriosus) |
PF00005(ABC_tran) | 5 | ILE A 20ILE A 5VAL A 10THR A 46ILE A 47 | None | 1.49A | 5mzrD-1sgwA:0.0 | 5mzrD-1sgwA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1spi | FRUCTOSE1,6-BISPHOSPHATASE (Spinaciaoleracea) |
PF00316(FBPase) | 5 | TYR A 123ILE A 148ILE A 124VAL A 43ILE A 104 | None | 1.38A | 5mzrD-1spiA:0.0 | 5mzrD-1spiA:11.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ug8 | POLY(A)-SPECIFICRIBONUCLEASE (Mus musculus) |
PF01424(R3H) | 5 | ILE A 20ILE A 73VAL A 16TYR A 46ILE A 71 | None | 1.23A | 5mzrD-1ug8A:undetectable | 5mzrD-1ug8A:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ug8 | POLY(A)-SPECIFICRIBONUCLEASE (Mus musculus) |
PF01424(R3H) | 5 | TYR A 53ILE A 73VAL A 16TYR A 46ILE A 71 | None | 1.25A | 5mzrD-1ug8A:undetectable | 5mzrD-1ug8A:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zit | TRANSCRIPTIONALREGULATOR (NTRCFAMILY) (Aquifexaeolicus) |
PF00072(Response_reg) | 5 | PRO A 28ILE A 20VAL A 6TYR A 26ILE A 113 | None | 1.41A | 5mzrD-1zitA:undetectable | 5mzrD-1zitA:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a1a | INTERFERON-INDUCED,DOUBLE-STRANDEDRNA-ACTIVATEDPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE B 430ILE B 420VAL B 402TYR B 454ILE B 477 | None | 1.26A | 5mzrD-2a1aB:2.8 | 5mzrD-2a1aB:12.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a5h | L-LYSINE2,3-AMINOMUTASE (Clostridiumsubterminale) |
PF04055(Radical_SAM)PF12544(LAM_C) | 5 | TYR A 37ILE A 28ILE A 59MET A 57ILE A 81 | None | 1.38A | 5mzrD-2a5hA:undetectable | 5mzrD-2a5hA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ani | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASEBETA SUBUNIT (Chlamydiatrachomatis) |
PF00268(Ribonuc_red_sm) | 5 | TYR A 222ILE A 56MET A 58TYR A 220ILE A 216 | None | 1.34A | 5mzrD-2aniA:3.6 | 5mzrD-2aniA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyv | XAA-HIS DIPEPTIDASE (Histophilussomni) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | ILE A 415ILE A 479VAL A 419TYR A 472ILE A 450 | None | 1.31A | 5mzrD-2qyvA:undetectable | 5mzrD-2qyvA:10.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r6f | EXCINUCLEASE ABCSUBUNIT A (Geobacillusstearothermophilus) |
PF00005(ABC_tran) | 5 | PRO A 22TYR A 554ILE A 556VAL A 19ILE A 540 | None | 1.30A | 5mzrD-2r6fA:undetectable | 5mzrD-2r6fA:5.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x49 | INVASION PROTEININVA (Salmonellaenterica) |
PF00771(FHIPEP) | 5 | ILE A 601ILE A 654MET A 657VAL A 600ILE A 628 | None | 1.12A | 5mzrD-2x49A:undetectable | 5mzrD-2x49A:11.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xkk | TOPOISOMERASE IV (Acinetobacterbaumannii) |
PF00521(DNA_topoisoIV)PF00986(DNA_gyraseB_C)PF01751(Toprim) | 5 | PRO A1217TYR A1243ILE A1235VAL A1331ILE A1347 | None | 1.30A | 5mzrD-2xkkA:undetectable | 5mzrD-2xkkA:7.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xsb | HYALURONOGLUCOSAMINIDASE (Oceanicolagranulosus) |
PF07555(NAGidase) | 5 | PRO A 255ILE A 266MET A 31THR A 253ILE A 252 | None | 1.14A | 5mzrD-2xsbA:3.7 | 5mzrD-2xsbA:11.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z01 | PHOSPHORIBOSYLFORMYLGLYCINAMIDINECYCLO-LIGASE (Geobacilluskaustophilus) |
PF00586(AIRS)PF02769(AIRS_C) | 5 | ILE A 241ILE A 167MET A 244VAL A 235ILE A 93 | None | 1.35A | 5mzrD-2z01A:undetectable | 5mzrD-2z01A:13.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3af5 | PUTATIVEUNCHARACTERIZEDPROTEIN PH1404 (Pyrococcushorikoshii) |
PF07521(RMMBL)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 5 | PRO A 455TYR A 457ILE A 518ILE A 517ILE A 420 | None | 1.47A | 5mzrD-3af5A:undetectable | 5mzrD-3af5A:8.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dzd | TRANSCRIPTIONALREGULATOR (NTRCFAMILY) (Aquifexaeolicus) |
PF00072(Response_reg)PF00158(Sigma54_activat) | 5 | PRO A 28ILE A 20VAL A 6TYR A 26ILE A 113 | None | 1.25A | 5mzrD-3dzdA:undetectable | 5mzrD-3dzdA:12.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ffh | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Listeriainnocua) |
PF00155(Aminotran_1_2) | 5 | TYR A 118ILE A 94VAL A 90THR A 217ILE A 215 | NoneNoneSO4 A 361 (-3.5A)NoneNone | 1.36A | 5mzrD-3ffhA:undetectable | 5mzrD-3ffhA:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fhh | OUTER MEMBRANE HEMERECEPTOR SHUA (Shigelladysenteriae) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | ILE A 61MET A 63VAL A 45TYR A 122ILE A 120 | None | 1.37A | 5mzrD-3fhhA:undetectable | 5mzrD-3fhhA:8.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i7f | ASPARTYL-TRNASYNTHETASE (Entamoebahistolytica) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 5 | ILE A 239ILE A 372VAL A 532TYR A 523THR A 520 | None | 1.27A | 5mzrD-3i7fA:undetectable | 5mzrD-3i7fA:10.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3irv | CYSTEINE HYDROLASE (Pseudomonassavastanoi) |
PF00857(Isochorismatase) | 5 | ILE A 53ILE A 169VAL A 55THR A 183ILE A 184 | None | 1.12A | 5mzrD-3irvA:undetectable | 5mzrD-3irvA:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khz | PUTATIVE DIPEPTIDASESACOL1801 (Staphylococcusaureus) |
PF01546(Peptidase_M20) | 5 | TYR A 125ILE A 129VAL A 6TYR A 458THR A 455 | None | 1.46A | 5mzrD-3khzA:undetectable | 5mzrD-3khzA:12.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lgx | D-ALANINE--POLY(PHOSPHORIBITOL) LIGASESUBUNIT 1 (Streptococcuspyogenes) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | PRO A 97ILE A 91ILE A 94VAL A 79ILE A 145 | None | 1.46A | 5mzrD-3lgxA:undetectable | 5mzrD-3lgxA:11.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mgw | LYSOZYME G (Salmo salar) |
PF01464(SLT) | 5 | ILE A 69ILE A 70MET A 94TYR A 185ILE A 52 | None | 1.40A | 5mzrD-3mgwA:undetectable | 5mzrD-3mgwA:17.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubg | NEURAL-CADHERIN (Drosophilamelanogaster) |
PF00028(Cadherin) | 5 | TYR A 685ILE A 699ILE A 705VAL A 727ILE A 671 | None | 1.26A | 5mzrD-3ubgA:undetectable | 5mzrD-3ubgA:13.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ux8 | EXCINUCLEASE ABC, ASUBUNIT (Geobacillus sp.Y412MC52) |
PF00005(ABC_tran) | 5 | PRO A 22TYR A 554ILE A 556VAL A 19ILE A 540 | None | 1.34A | 5mzrD-3ux8A:undetectable | 5mzrD-3ux8A:8.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v9f | TWO-COMPONENT SYSTEMSENSOR HISTIDINEKINASE/RESPONSEREGULATOR, HYBRID(ONE-COMPONENTSYSTEM) (Bacteroidesthetaiotaomicron) |
PF07494(Reg_prop)PF07495(Y_Y_Y) | 5 | ILE A 482ILE A 491VAL A 469TYR A 448ILE A 458 | None | 1.04A | 5mzrD-3v9fA:undetectable | 5mzrD-3v9fA:8.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wyh | LYSOZYME G (Struthiocamelus) |
PF01464(SLT) | 5 | ILE A 69ILE A 70MET A 94TYR A 185ILE A 52 | None | 1.30A | 5mzrD-3wyhA:undetectable | 5mzrD-3wyhA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4by9 | FIBRILLARIN-LIKERRNA/TRNA2'-O-METHYLTRANSFERASE (Pyrococcusfuriosus) |
PF01269(Fibrillarin) | 5 | TYR E 102ILE E 125ILE E 124TYR E 79ILE E 82 | None | 1.38A | 5mzrD-4by9E:undetectable | 5mzrD-4by9E:14.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fzy | EXODEOXYRIBONUCLEASE10 (Escherichiacoli) |
PF00929(RNase_T) | 5 | PRO A 90ILE A 16ILE A 19VAL A 88ILE A 5 | None | 1.32A | 5mzrD-4fzyA:undetectable | 5mzrD-4fzyA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4go4 | PUTATIVEGAMMA-HYDROXYMUCONICSEMIALDEHYDEDEHYDROGENASE (Pseudomonas sp.WBC-3) |
PF00171(Aldedh) | 5 | ILE A 171MET A 159VAL A 200THR A 181ILE A 184 | None | 1.44A | 5mzrD-4go4A:undetectable | 5mzrD-4go4A:10.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gv8 | DUTPASE (Staphylococcusvirus 11) |
PF00692(dUTPase) | 5 | TYR A 126ILE A 110ILE A 128VAL A 67ILE A 90 | None | 1.11A | 5mzrD-4gv8A:undetectable | 5mzrD-4gv8A:24.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jys | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Plasmodiumvivax) |
PF00254(FKBP_C) | 5 | ILE A 99ILE A 150VAL A 183TYR A 88ILE A 148 | None | 1.21A | 5mzrD-4jysA:undetectable | 5mzrD-4jysA:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l8n | PDZ DOMAIN PROTEIN (Parabacteroidesdistasonis) |
PF00595(PDZ)PF13590(DUF4136) | 5 | ILE A 355ILE A 331VAL A 461TYR A 432ILE A 364 | None | 1.38A | 5mzrD-4l8nA:undetectable | 5mzrD-4l8nA:10.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lbw | ELONGATION FACTORTU-A (Thermusthermophilus) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 5 | PRO A 169TYR A 209ILE A 210ILE A 206ILE A 103 | None | 1.31A | 5mzrD-4lbwA:undetectable | 5mzrD-4lbwA:12.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q4j | ABC TRANSPORTER (Thermotogamaritima) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 5 | ILE A 272MET A 267VAL A 254TYR A 278ILE A 151 | None | 1.21A | 5mzrD-4q4jA:2.7 | 5mzrD-4q4jA:9.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8b | EXO-XYLOGLUCANASE (unculturedbacterium) |
PF00150(Cellulase) | 5 | ILE A 428ILE A 467VAL A 336TYR A 229ILE A 144 | None | 1.36A | 5mzrD-4w8bA:undetectable | 5mzrD-4w8bA:14.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xk1 | PHOSPHOSERINEAMINOTRANSFERASE (Pseudomonasaeruginosa) |
PF00266(Aminotran_5) | 5 | PRO A 163TYR A 148ILE A 98VAL A 146THR A 165 | None | 1.41A | 5mzrD-4xk1A:undetectable | 5mzrD-4xk1A:12.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xyd | NITRIC-OXIDEREDUCTASE SUBUNIT BNORC-LIKE PROTEIN (Roseobacterdenitrificans) |
PF00034(Cytochrom_C)PF00115(COX1) | 5 | PRO A 253TYR B 35ILE B 36TYR A 247ILE A 250 | None | 1.35A | 5mzrD-4xydA:2.2 | 5mzrD-4xydA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yeu | CYS-LOOPLIGAND-GATED IONCHANNEL,PROTON-GATEDION CHANNEL (Dickeyachrysanthemi;Gloeobacterviolaceus) |
PF02931(Neur_chan_LBD) | 6 | ILE A 208ILE A 209MET A 212TYR A 261THR A 262ILE A 265 | None | 0.59A | 5mzrD-4yeuA:19.8 | 5mzrD-4yeuA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yeu | CYS-LOOPLIGAND-GATED IONCHANNEL,PROTON-GATEDION CHANNEL (Dickeyachrysanthemi;Gloeobacterviolaceus) |
PF02931(Neur_chan_LBD) | 6 | PRO A 120ILE A 208MET A 212TYR A 261THR A 262ILE A 265 | None | 0.83A | 5mzrD-4yeuA:19.8 | 5mzrD-4yeuA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yeu | CYS-LOOPLIGAND-GATED IONCHANNEL,PROTON-GATEDION CHANNEL (Dickeyachrysanthemi;Gloeobacterviolaceus) |
PF02931(Neur_chan_LBD) | 5 | TYR A 204ILE A 208ILE A 209MET A 212THR A 262 | None | 0.89A | 5mzrD-4yeuA:19.8 | 5mzrD-4yeuA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yeu | CYS-LOOPLIGAND-GATED IONCHANNEL,PROTON-GATEDION CHANNEL (Dickeyachrysanthemi;Gloeobacterviolaceus) |
PF02931(Neur_chan_LBD) | 5 | TYR A 204ILE A 208ILE A 209MET A 212VAL A 249 | None | 1.15A | 5mzrD-4yeuA:19.8 | 5mzrD-4yeuA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zba | PCURE2P8 (Phanerochaetechrysosporium) |
PF00043(GST_C)PF02798(GST_N) | 5 | ILE A 92ILE A 171MET A 166THR A 208ILE A 209 | None | 1.26A | 5mzrD-4zbaA:2.1 | 5mzrD-4zbaA:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d6n | ACYL-COA SYNTHASE (Mycolicibacteriumsmegmatis) |
PF00501(AMP-binding) | 5 | ILE A 403ILE A 420VAL A 417THR A 481ILE A 480 | None | 1.48A | 5mzrD-5d6nA:undetectable | 5mzrD-5d6nA:12.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ey8 | ACYL-COA SYNTHASE (Mycolicibacteriumsmegmatis) |
PF00501(AMP-binding) | 5 | ILE A 403ILE A 420VAL A 417THR A 481ILE A 480 | NoneNoneNoneNone5SV A 701 (-3.6A) | 1.34A | 5mzrD-5ey8A:undetectable | 5mzrD-5ey8A:10.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g37 | 41.9 KDAINSECTICIDAL TOXIN (Lysinibacillussphaericus) |
PF05431(Toxin_10) | 5 | ILE A 256ILE A 193VAL A 258THR A 272ILE A 275 | None | 1.12A | 5mzrD-5g37A:undetectable | 5mzrD-5g37A:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ix1 | MORC FAMILY CW-TYPEZINC FINGER PROTEIN3 (Mus musculus) |
PF07496(zf-CW)PF13589(HATPase_c_3) | 5 | ILE A 347ILE A 315MET A 317THR A 370ILE A 371 | None | 1.41A | 5mzrD-5ix1A:undetectable | 5mzrD-5ix1A:11.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j8q | CYSTEINE DESULFURASESUFS (Bacillussubtilis) |
PF00266(Aminotran_5) | 5 | ILE A 3ILE A 6MET A 1TYR A 380ILE A 299 | None | 1.06A | 5mzrD-5j8qA:undetectable | 5mzrD-5j8qA:12.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8s | CAMP-DEPENDENTPROTEIN KINASEREGULATORY SUBUNIT (Plasmodiumfalciparum) |
PF00027(cNMP_binding) | 5 | ILE A 413MET A 316VAL A 324TYR A 374ILE A 312 | None | 1.44A | 5mzrD-5k8sA:undetectable | 5mzrD-5k8sA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ks8 | PYRUVATE CARBOXYLASESUBUNIT ALPHA (Methylobacillusflagellatus) |
PF00289(Biotin_carb_N)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | ILE A 354ILE A 377MET A 371VAL A 411THR A 416 | None | 1.14A | 5mzrD-5ks8A:undetectable | 5mzrD-5ks8A:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lgg | ANAPHASE-PROMOTINGCOMPLEX SUBUNIT1,ANAPHASE-PROMOTINGCOMPLEX SUBUNIT1,ANAPHASE-PROMOTINGCOMPLEX SUBUNIT1,ANAPHASE-PROMOTINGCOMPLEX SUBUNIT 1 (Homo sapiens) |
PF12859(ANAPC1) | 5 | ILE A 12ILE A 609VAL A 506THR A 487ILE A 485 | None | 1.38A | 5mzrD-5lggA:undetectable | 5mzrD-5lggA:11.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lm8 | 'MULTICOPPER OXIDASE (Aspergillusniger) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | TYR A 151ILE A 84ILE A 167VAL A 94ILE A 112 | None | 1.41A | 5mzrD-5lm8A:2.0 | 5mzrD-5lm8A:10.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o5j | 30S RIBOSOMALPROTEIN S2 (Mycolicibacteriumsmegmatis) |
PF00318(Ribosomal_S2) | 5 | ILE V 186ILE V 200VAL V 164THR V 214ILE V 217 | None | 1.41A | 5mzrD-5o5jV:undetectable | 5mzrD-5o5jV:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ojs | TRANSCRIPTION-ASSOCIATED PROTEIN 1 (Saccharomycescerevisiae) |
PF00454(PI3_PI4_kinase)PF02259(FAT) | 5 | TYR T 313ILE T 354ILE T 310VAL T 325TYR T 238 | None | 1.27A | 5mzrD-5ojsT:undetectable | 5mzrD-5ojsT:1.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5v6n | PROTON-GATED IONCHANNEL (Gloeobacterviolaceus) |
no annotation | 9 | PRO C 120TYR C 197ILE C 201ILE C 202MET C 205VAL C 242TYR C 254THR C 255ILE C 258 | None | 0.49A | 5mzrD-5v6nC:35.9 | 5mzrD-5v6nC:97.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vf6 | SINGLE CHAINVARIABLE FRAGMENT (Gallus gallus) |
no annotation | 5 | PRO A 41TYR A 218ILE A 160TYR A 32ILE A 232 | None | 1.29A | 5mzrD-5vf6A:undetectable | 5mzrD-5vf6A:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wpi | HSVA (Erwiniaamylovora) |
no annotation | 5 | PRO A 273ILE A 212MET A 207VAL A 262ILE A 366 | PRO A 273 ( 1.1A)ILE A 212 ( 0.6A)MET A 207 ( 0.0A)VAL A 262 ( 0.6A)ILE A 366 ( 0.7A) | 1.42A | 5mzrD-5wpiA:undetectable | 5mzrD-5wpiA:14.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xb7 | BETA-GALACTOSIDASE (Bifidobacteriumanimalis) |
no annotation | 5 | TYR A 280ILE A 279VAL A 277TYR A 344ILE A 342 | None | 1.31A | 5mzrD-5xb7A:undetectable | 5mzrD-5xb7A:11.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xs2 | CYCLIN-C (Homo sapiens) |
PF00134(Cyclin_N)PF16899(Cyclin_C_2) | 5 | TYR B 192ILE B 230ILE B 197VAL B 233THR B 186 | None | 1.30A | 5mzrD-5xs2B:2.5 | 5mzrD-5xs2B:14.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xwz | UNPLACED GENOMICSCAFFOLDSUPERCONT1.36, WHOLEGENOME SHOTGUNSEQUENCE (Cladophialophorabantiana) |
no annotation | 5 | PRO A 127ILE A 236ILE A 234VAL A 213ILE A 228 | None | 1.37A | 5mzrD-5xwzA:undetectable | 5mzrD-5xwzA:20.88 |