SIMILAR PATTERNS OF AMINO ACIDS FOR 5MZR_D_PFLD410

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus)
PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing)
5 TYR A 194
ILE A 205
ILE A 182
TYR A 216
ILE A 146
None
1.24A 5mzrD-1dq3A:
0.0
5mzrD-1dq3A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT


(Methanopyrus
kandleri)
PF02240
(MCR_gamma)
5 TYR C  22
ILE C 100
ILE C 104
THR C 218
ILE C 220
None
1.44A 5mzrD-1e6vC:
0.0
5mzrD-1e6vC:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7j PROTEIN YCIO

(Escherichia
coli)
PF01300
(Sua5_yciO_yrdC)
5 TYR A  32
ILE A  30
ILE A 172
VAL A  24
ILE A  17
None
1.28A 5mzrD-1k7jA:
0.0
5mzrD-1k7jA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT


(Homo sapiens)
no annotation 5 ILE B  94
VAL B 120
TYR B 125
THR B 124
ILE B  79
None
1.36A 5mzrD-1l1oB:
0.0
5mzrD-1l1oB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvj MOLYBDOPTERIN
CONVERTING FACTOR
SUBUNIT 2


(Escherichia
coli)
PF02391
(MoaE)
5 PRO A  56
ILE A  85
VAL A   8
TYR A  55
THR A  59
None
1.49A 5mzrD-1nvjA:
0.0
5mzrD-1nvjA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1o CELL DIVISION
CONTROL PROTEIN 24


(Saccharomyces
cerevisiae)
PF00564
(PB1)
5 TYR A 854
ILE A 816
ILE A 813
TYR A 768
ILE A 802
None
1.35A 5mzrD-1q1oA:
0.0
5mzrD-1q1oA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qva INITIATION FACTOR 4A

(Saccharomyces
cerevisiae)
PF00270
(DEAD)
5 PRO A  54
TYR A  16
ILE A 221
VAL A  19
ILE A  47
None
1.28A 5mzrD-1qvaA:
undetectable
5mzrD-1qvaA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgw PUTATIVE ABC
TRANSPORTER


(Pyrococcus
furiosus)
PF00005
(ABC_tran)
5 ILE A  20
ILE A   5
VAL A  10
THR A  46
ILE A  47
None
1.49A 5mzrD-1sgwA:
0.0
5mzrD-1sgwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spi FRUCTOSE
1,6-BISPHOSPHATASE


(Spinacia
oleracea)
PF00316
(FBPase)
5 TYR A 123
ILE A 148
ILE A 124
VAL A  43
ILE A 104
None
1.38A 5mzrD-1spiA:
0.0
5mzrD-1spiA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug8 POLY(A)-SPECIFIC
RIBONUCLEASE


(Mus musculus)
PF01424
(R3H)
5 ILE A  20
ILE A  73
VAL A  16
TYR A  46
ILE A  71
None
1.23A 5mzrD-1ug8A:
undetectable
5mzrD-1ug8A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug8 POLY(A)-SPECIFIC
RIBONUCLEASE


(Mus musculus)
PF01424
(R3H)
5 TYR A  53
ILE A  73
VAL A  16
TYR A  46
ILE A  71
None
1.25A 5mzrD-1ug8A:
undetectable
5mzrD-1ug8A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zit TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)


(Aquifex
aeolicus)
PF00072
(Response_reg)
5 PRO A  28
ILE A  20
VAL A   6
TYR A  26
ILE A 113
None
1.41A 5mzrD-1zitA:
undetectable
5mzrD-1zitA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
5 ILE B 430
ILE B 420
VAL B 402
TYR B 454
ILE B 477
None
1.26A 5mzrD-2a1aB:
2.8
5mzrD-2a1aB:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE


(Clostridium
subterminale)
PF04055
(Radical_SAM)
PF12544
(LAM_C)
5 TYR A  37
ILE A  28
ILE A  59
MET A  57
ILE A  81
None
1.38A 5mzrD-2a5hA:
undetectable
5mzrD-2a5hA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT


(Chlamydia
trachomatis)
PF00268
(Ribonuc_red_sm)
5 TYR A 222
ILE A  56
MET A  58
TYR A 220
ILE A 216
None
1.34A 5mzrD-2aniA:
3.6
5mzrD-2aniA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 ILE A 415
ILE A 479
VAL A 419
TYR A 472
ILE A 450
None
1.31A 5mzrD-2qyvA:
undetectable
5mzrD-2qyvA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A


(Geobacillus
stearothermophilus)
PF00005
(ABC_tran)
5 PRO A  22
TYR A 554
ILE A 556
VAL A  19
ILE A 540
None
1.30A 5mzrD-2r6fA:
undetectable
5mzrD-2r6fA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x49 INVASION PROTEIN
INVA


(Salmonella
enterica)
PF00771
(FHIPEP)
5 ILE A 601
ILE A 654
MET A 657
VAL A 600
ILE A 628
None
1.12A 5mzrD-2x49A:
undetectable
5mzrD-2x49A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkk TOPOISOMERASE IV

(Acinetobacter
baumannii)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
5 PRO A1217
TYR A1243
ILE A1235
VAL A1331
ILE A1347
None
1.30A 5mzrD-2xkkA:
undetectable
5mzrD-2xkkA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE


(Oceanicola
granulosus)
PF07555
(NAGidase)
5 PRO A 255
ILE A 266
MET A  31
THR A 253
ILE A 252
None
1.14A 5mzrD-2xsbA:
3.7
5mzrD-2xsbA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE


(Geobacillus
kaustophilus)
PF00586
(AIRS)
PF02769
(AIRS_C)
5 ILE A 241
ILE A 167
MET A 244
VAL A 235
ILE A  93
None
1.35A 5mzrD-2z01A:
undetectable
5mzrD-2z01A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404


(Pyrococcus
horikoshii)
PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7)
5 PRO A 455
TYR A 457
ILE A 518
ILE A 517
ILE A 420
None
1.47A 5mzrD-3af5A:
undetectable
5mzrD-3af5A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzd TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)


(Aquifex
aeolicus)
PF00072
(Response_reg)
PF00158
(Sigma54_activat)
5 PRO A  28
ILE A  20
VAL A   6
TYR A  26
ILE A 113
None
1.25A 5mzrD-3dzdA:
undetectable
5mzrD-3dzdA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Listeria
innocua)
PF00155
(Aminotran_1_2)
5 TYR A 118
ILE A  94
VAL A  90
THR A 217
ILE A 215
None
None
SO4  A 361 (-3.5A)
None
None
1.36A 5mzrD-3ffhA:
undetectable
5mzrD-3ffhA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA


(Shigella
dysenteriae)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
5 ILE A  61
MET A  63
VAL A  45
TYR A 122
ILE A 120
None
1.37A 5mzrD-3fhhA:
undetectable
5mzrD-3fhhA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7f ASPARTYL-TRNA
SYNTHETASE


(Entamoeba
histolytica)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
5 ILE A 239
ILE A 372
VAL A 532
TYR A 523
THR A 520
None
1.27A 5mzrD-3i7fA:
undetectable
5mzrD-3i7fA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irv CYSTEINE HYDROLASE

(Pseudomonas
savastanoi)
PF00857
(Isochorismatase)
5 ILE A  53
ILE A 169
VAL A  55
THR A 183
ILE A 184
None
1.12A 5mzrD-3irvA:
undetectable
5mzrD-3irvA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khz PUTATIVE DIPEPTIDASE
SACOL1801


(Staphylococcus
aureus)
PF01546
(Peptidase_M20)
5 TYR A 125
ILE A 129
VAL A   6
TYR A 458
THR A 455
None
1.46A 5mzrD-3khzA:
undetectable
5mzrD-3khzA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1


(Streptococcus
pyogenes)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 PRO A  97
ILE A  91
ILE A  94
VAL A  79
ILE A 145
None
1.46A 5mzrD-3lgxA:
undetectable
5mzrD-3lgxA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgw LYSOZYME G

(Salmo salar)
PF01464
(SLT)
5 ILE A  69
ILE A  70
MET A  94
TYR A 185
ILE A  52
None
1.40A 5mzrD-3mgwA:
undetectable
5mzrD-3mgwA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubg NEURAL-CADHERIN

(Drosophila
melanogaster)
PF00028
(Cadherin)
5 TYR A 685
ILE A 699
ILE A 705
VAL A 727
ILE A 671
None
1.26A 5mzrD-3ubgA:
undetectable
5mzrD-3ubgA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT


(Geobacillus sp.
Y412MC52)
PF00005
(ABC_tran)
5 PRO A  22
TYR A 554
ILE A 556
VAL A  19
ILE A 540
None
1.34A 5mzrD-3ux8A:
undetectable
5mzrD-3ux8A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)


(Bacteroides
thetaiotaomicron)
PF07494
(Reg_prop)
PF07495
(Y_Y_Y)
5 ILE A 482
ILE A 491
VAL A 469
TYR A 448
ILE A 458
None
1.04A 5mzrD-3v9fA:
undetectable
5mzrD-3v9fA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyh LYSOZYME G

(Struthio
camelus)
PF01464
(SLT)
5 ILE A  69
ILE A  70
MET A  94
TYR A 185
ILE A  52
None
1.30A 5mzrD-3wyhA:
undetectable
5mzrD-3wyhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE


(Pyrococcus
furiosus)
PF01269
(Fibrillarin)
5 TYR E 102
ILE E 125
ILE E 124
TYR E  79
ILE E  82
None
1.38A 5mzrD-4by9E:
undetectable
5mzrD-4by9E:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzy EXODEOXYRIBONUCLEASE
10


(Escherichia
coli)
PF00929
(RNase_T)
5 PRO A  90
ILE A  16
ILE A  19
VAL A  88
ILE A   5
None
1.32A 5mzrD-4fzyA:
undetectable
5mzrD-4fzyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE


(Pseudomonas sp.
WBC-3)
PF00171
(Aldedh)
5 ILE A 171
MET A 159
VAL A 200
THR A 181
ILE A 184
None
1.44A 5mzrD-4go4A:
undetectable
5mzrD-4go4A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv8 DUTPASE

(Staphylococcus
virus 11)
PF00692
(dUTPase)
5 TYR A 126
ILE A 110
ILE A 128
VAL A  67
ILE A  90
None
1.11A 5mzrD-4gv8A:
undetectable
5mzrD-4gv8A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jys PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Plasmodium
vivax)
PF00254
(FKBP_C)
5 ILE A  99
ILE A 150
VAL A 183
TYR A  88
ILE A 148
None
1.21A 5mzrD-4jysA:
undetectable
5mzrD-4jysA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8n PDZ DOMAIN PROTEIN

(Parabacteroides
distasonis)
PF00595
(PDZ)
PF13590
(DUF4136)
5 ILE A 355
ILE A 331
VAL A 461
TYR A 432
ILE A 364
None
1.38A 5mzrD-4l8nA:
undetectable
5mzrD-4l8nA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A


(Thermus
thermophilus)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
5 PRO A 169
TYR A 209
ILE A 210
ILE A 206
ILE A 103
None
1.31A 5mzrD-4lbwA:
undetectable
5mzrD-4lbwA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4j ABC TRANSPORTER

(Thermotoga
maritima)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
5 ILE A 272
MET A 267
VAL A 254
TYR A 278
ILE A 151
None
1.21A 5mzrD-4q4jA:
2.7
5mzrD-4q4jA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8b EXO-XYLOGLUCANASE

(uncultured
bacterium)
PF00150
(Cellulase)
5 ILE A 428
ILE A 467
VAL A 336
TYR A 229
ILE A 144
None
1.36A 5mzrD-4w8bA:
undetectable
5mzrD-4w8bA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk1 PHOSPHOSERINE
AMINOTRANSFERASE


(Pseudomonas
aeruginosa)
PF00266
(Aminotran_5)
5 PRO A 163
TYR A 148
ILE A  98
VAL A 146
THR A 165
None
1.41A 5mzrD-4xk1A:
undetectable
5mzrD-4xk1A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
NORC-LIKE PROTEIN


(Roseobacter
denitrificans)
PF00034
(Cytochrom_C)
PF00115
(COX1)
5 PRO A 253
TYR B  35
ILE B  36
TYR A 247
ILE A 250
None
1.35A 5mzrD-4xydA:
2.2
5mzrD-4xydA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
6 ILE A 208
ILE A 209
MET A 212
TYR A 261
THR A 262
ILE A 265
None
0.59A 5mzrD-4yeuA:
19.8
5mzrD-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
6 PRO A 120
ILE A 208
MET A 212
TYR A 261
THR A 262
ILE A 265
None
0.83A 5mzrD-4yeuA:
19.8
5mzrD-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
5 TYR A 204
ILE A 208
ILE A 209
MET A 212
THR A 262
None
0.89A 5mzrD-4yeuA:
19.8
5mzrD-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
5 TYR A 204
ILE A 208
ILE A 209
MET A 212
VAL A 249
None
1.15A 5mzrD-4yeuA:
19.8
5mzrD-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zba PCURE2P8

(Phanerochaete
chrysosporium)
PF00043
(GST_C)
PF02798
(GST_N)
5 ILE A  92
ILE A 171
MET A 166
THR A 208
ILE A 209
None
1.26A 5mzrD-4zbaA:
2.1
5mzrD-4zbaA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis)
PF00501
(AMP-binding)
5 ILE A 403
ILE A 420
VAL A 417
THR A 481
ILE A 480
None
1.48A 5mzrD-5d6nA:
undetectable
5mzrD-5d6nA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis)
PF00501
(AMP-binding)
5 ILE A 403
ILE A 420
VAL A 417
THR A 481
ILE A 480
None
None
None
None
5SV  A 701 (-3.6A)
1.34A 5mzrD-5ey8A:
undetectable
5mzrD-5ey8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g37 41.9 KDA
INSECTICIDAL TOXIN


(Lysinibacillus
sphaericus)
PF05431
(Toxin_10)
5 ILE A 256
ILE A 193
VAL A 258
THR A 272
ILE A 275
None
1.12A 5mzrD-5g37A:
undetectable
5mzrD-5g37A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix1 MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
3


(Mus musculus)
PF07496
(zf-CW)
PF13589
(HATPase_c_3)
5 ILE A 347
ILE A 315
MET A 317
THR A 370
ILE A 371
None
1.41A 5mzrD-5ix1A:
undetectable
5mzrD-5ix1A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8q CYSTEINE DESULFURASE
SUFS


(Bacillus
subtilis)
PF00266
(Aminotran_5)
5 ILE A   3
ILE A   6
MET A   1
TYR A 380
ILE A 299
None
1.06A 5mzrD-5j8qA:
undetectable
5mzrD-5j8qA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8s CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT


(Plasmodium
falciparum)
PF00027
(cNMP_binding)
5 ILE A 413
MET A 316
VAL A 324
TYR A 374
ILE A 312
None
1.44A 5mzrD-5k8sA:
undetectable
5mzrD-5k8sA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA


(Methylobacillus
flagellatus)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 ILE A 354
ILE A 377
MET A 371
VAL A 411
THR A 416
None
1.14A 5mzrD-5ks8A:
undetectable
5mzrD-5ks8A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgg ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1


(Homo sapiens)
PF12859
(ANAPC1)
5 ILE A  12
ILE A 609
VAL A 506
THR A 487
ILE A 485
None
1.38A 5mzrD-5lggA:
undetectable
5mzrD-5lggA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
5 TYR A 151
ILE A  84
ILE A 167
VAL A  94
ILE A 112
None
1.41A 5mzrD-5lm8A:
2.0
5mzrD-5lm8A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5j 30S RIBOSOMAL
PROTEIN S2


(Mycolicibacterium
smegmatis)
PF00318
(Ribosomal_S2)
5 ILE V 186
ILE V 200
VAL V 164
THR V 214
ILE V 217
None
1.41A 5mzrD-5o5jV:
undetectable
5mzrD-5o5jV:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1


(Saccharomyces
cerevisiae)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
5 TYR T 313
ILE T 354
ILE T 310
VAL T 325
TYR T 238
None
1.27A 5mzrD-5ojsT:
undetectable
5mzrD-5ojsT:
1.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL


(Gloeobacter
violaceus)
no annotation 9 PRO C 120
TYR C 197
ILE C 201
ILE C 202
MET C 205
VAL C 242
TYR C 254
THR C 255
ILE C 258
None
0.49A 5mzrD-5v6nC:
35.9
5mzrD-5v6nC:
97.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf6 SINGLE CHAIN
VARIABLE FRAGMENT


(Gallus gallus)
no annotation 5 PRO A  41
TYR A 218
ILE A 160
TYR A  32
ILE A 232
None
1.29A 5mzrD-5vf6A:
undetectable
5mzrD-5vf6A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpi HSVA

(Erwinia
amylovora)
no annotation 5 PRO A 273
ILE A 212
MET A 207
VAL A 262
ILE A 366
PRO  A 273 ( 1.1A)
ILE  A 212 ( 0.6A)
MET  A 207 ( 0.0A)
VAL  A 262 ( 0.6A)
ILE  A 366 ( 0.7A)
1.42A 5mzrD-5wpiA:
undetectable
5mzrD-5wpiA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis)
no annotation 5 TYR A 280
ILE A 279
VAL A 277
TYR A 344
ILE A 342
None
1.31A 5mzrD-5xb7A:
undetectable
5mzrD-5xb7A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xs2 CYCLIN-C

(Homo sapiens)
PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2)
5 TYR B 192
ILE B 230
ILE B 197
VAL B 233
THR B 186
None
1.30A 5mzrD-5xs2B:
2.5
5mzrD-5xs2B:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwz UNPLACED GENOMIC
SCAFFOLD
SUPERCONT1.36, WHOLE
GENOME SHOTGUN
SEQUENCE


(Cladophialophora
bantiana)
no annotation 5 PRO A 127
ILE A 236
ILE A 234
VAL A 213
ILE A 228
None
1.37A 5mzrD-5xwzA:
undetectable
5mzrD-5xwzA:
20.88