SIMILAR PATTERNS OF AMINO ACIDS FOR 5MZR_C_PFLC409_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clx XYLANASE A

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10) 		5 TYR A 178
ILE A 233
ILE A 242
VAL A 197
TYR A 177
 None
 1.12A 5mzrC-1clxA:
0.0		 5mzrC-1clxA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5v S12 TRANSCRIPTION
FACTOR (FKH-14)

(Homo sapiens) 		PF00250
(Forkhead) 		5 TYR A  41
TYR A   9
ILE A  13
TYR A  31
ILE A  30
 None
 1.40A 5mzrC-1d5vA:
undetectable		 5mzrC-1d5vA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 TYR A  65
TYR A  18
ILE A  20
ILE A  74
ILE A  61
 None
 1.11A 5mzrC-1dedA:
0.0		 5mzrC-1dedA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 TYR A 194
ILE A 205
ILE A 182
TYR A 216
ILE A 146
 None
 1.23A 5mzrC-1dq3A:
0.0		 5mzrC-1dq3A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT

(Methanopyrus
kandleri) 		PF02240
(MCR_gamma) 		5 TYR C  22
ILE C 100
ILE C 104
THR C 218
ILE C 220
 None
 1.44A 5mzrC-1e6vC:
0.0		 5mzrC-1e6vC:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7j PROTEIN YCIO

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC) 		5 TYR A  32
ILE A  30
ILE A 172
VAL A  24
ILE A  17
 None
 1.26A 5mzrC-1k7jA:
0.0		 5mzrC-1k7jA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcl CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 TYR A  65
TYR A  18
ILE A  20
ILE A  74
ILE A  61
 None
 1.13A 5mzrC-1kclA:
0.0		 5mzrC-1kclA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT

(Homo sapiens) 		no annotation 5 ILE B  94
VAL B 120
TYR B 125
THR B 124
ILE B  79
 None
 1.33A 5mzrC-1l1oB:
0.0		 5mzrC-1l1oB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 PRO A 343
ILE A 381
ILE A 380
TYR A 418
ILE A 346
 None
 1.38A 5mzrC-1la2A:
0.0		 5mzrC-1la2A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvj MOLYBDOPTERIN
CONVERTING FACTOR
SUBUNIT 2

(Escherichia
coli) 		PF02391
(MoaE) 		5 PRO A  56
ILE A  85
VAL A   8
TYR A  55
THR A  59
 None
 1.44A 5mzrC-1nvjA:
undetectable		 5mzrC-1nvjA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 TYR A 618
TYR A 622
ILE A 555
TYR A 620
ILE A 629
 None
 1.30A 5mzrC-1qgdA:
undetectable		 5mzrC-1qgdA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qni NITROUS-OXIDE
REDUCTASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 5 PRO A 317
ILE A 353
ILE A 349
VAL A 314
ILE A 282
 None
 1.41A 5mzrC-1qniA:
undetectable		 5mzrC-1qniA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgw PUTATIVE ABC
TRANSPORTER

(Pyrococcus
furiosus) 		PF00005
(ABC_tran) 		5 ILE A  20
ILE A   5
VAL A  10
THR A  46
ILE A  47
 None
 1.49A 5mzrC-1sgwA:
undetectable		 5mzrC-1sgwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spi FRUCTOSE
1,6-BISPHOSPHATASE

(Spinacia
oleracea) 		PF00316
(FBPase) 		5 TYR A 123
ILE A 148
ILE A 124
VAL A  43
ILE A 104
 None
 1.39A 5mzrC-1spiA:
undetectable		 5mzrC-1spiA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug8 POLY(A)-SPECIFIC
RIBONUCLEASE

(Mus musculus) 		PF01424
(R3H) 		5 ILE A  20
ILE A  73
VAL A  16
TYR A  46
ILE A  71
 None
 1.20A 5mzrC-1ug8A:
undetectable		 5mzrC-1ug8A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug8 POLY(A)-SPECIFIC
RIBONUCLEASE

(Mus musculus) 		PF01424
(R3H) 		5 TYR A  53
ILE A  73
VAL A  16
TYR A  46
ILE A  71
 None
 1.26A 5mzrC-1ug8A:
undetectable		 5mzrC-1ug8A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 TYR A  79
TYR A  67
ILE A  62
TYR A  87
ILE A  89
 None
 1.21A 5mzrC-1z68A:
undetectable		 5mzrC-1z68A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		5 TYR A  37
ILE A  28
ILE A  59
MET A  57
ILE A  81
 None
 1.40A 5mzrC-2a5hA:
undetectable		 5mzrC-2a5hA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT

(Chlamydia
trachomatis) 		PF00268
(Ribonuc_red_sm) 		5 TYR A 222
ILE A  56
MET A  58
TYR A 220
ILE A 216
 None
 1.36A 5mzrC-2aniA:
3.6		 5mzrC-2aniA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 TYR A 202
PRO A 204
ILE A 332
ILE A 351
THR A 356
 None
 1.23A 5mzrC-2db3A:
undetectable		 5mzrC-2db3A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l2b STICHOLYSIN-2

(Stichodactyla
helianthus) 		PF06369
(Anemone_cytotox) 		5 TYR A  90
ILE A 171
ILE A 173
VAL A 100
ILE A 119
 None
 1.24A 5mzrC-2l2bA:
undetectable		 5mzrC-2l2bA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A 415
ILE A 479
VAL A 419
TYR A 472
ILE A 450
 None
 1.33A 5mzrC-2qyvA:
undetectable		 5mzrC-2qyvA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7e COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		5 TYR B1837
ILE B1771
VAL B1773
TYR B1786
ILE B1790
 None
 1.29A 5mzrC-2r7eB:
undetectable		 5mzrC-2r7eB:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 TYR A 753
ILE A 808
VAL A 788
THR A 763
ILE A 783
 None
 1.35A 5mzrC-2vsqA:
undetectable		 5mzrC-2vsqA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x49 INVASION PROTEIN
INVA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		5 ILE A 601
ILE A 654
MET A 657
VAL A 600
ILE A 628
 None
 1.14A 5mzrC-2x49A:
undetectable		 5mzrC-2x49A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkk TOPOISOMERASE IV

(Acinetobacter
baumannii) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		5 PRO A1217
TYR A1243
ILE A1235
VAL A1331
ILE A1347
 None
 1.33A 5mzrC-2xkkA:
1.4		 5mzrC-2xkkA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE

(Oceanicola
granulosus) 		PF07555
(NAGidase) 		5 ILE A 266
ILE A  26
MET A  31
THR A 253
ILE A 252
 None
 1.34A 5mzrC-2xsbA:
3.7		 5mzrC-2xsbA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE

(Oceanicola
granulosus) 		PF07555
(NAGidase) 		5 PRO A 255
ILE A 266
MET A  31
THR A 253
ILE A 252
 None
 1.13A 5mzrC-2xsbA:
3.7		 5mzrC-2xsbA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Geobacillus
kaustophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ILE A 241
ILE A 167
MET A 244
VAL A 235
ILE A  93
 None
 1.38A 5mzrC-2z01A:
undetectable		 5mzrC-2z01A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 PRO A 455
TYR A 457
ILE A 518
ILE A 517
ILE A 420
 None
 1.45A 5mzrC-3af5A:
undetectable		 5mzrC-3af5A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzd TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		5 PRO A  28
ILE A  20
VAL A   6
TYR A  26
ILE A 113
 None
 1.26A 5mzrC-3dzdA:
undetectable		 5mzrC-3dzdA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Listeria
innocua) 		PF00155
(Aminotran_1_2) 		5 TYR A 118
ILE A  94
VAL A  90
THR A 217
ILE A 215
 None
None
SO4  A 361 (-3.5A)
None
None
 1.34A 5mzrC-3ffhA:
undetectable		 5mzrC-3ffhA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M) 		5 TYR A  83
ILE A  66
VAL A  68
TYR A  86
THR A  24
 None
 1.47A 5mzrC-3fsxA:
undetectable		 5mzrC-3fsxA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf8 PUTATIVE
POLYSACCHARIDE
BINDING PROTEINS
(DUF1812)

(Bacteroides
thetaiotaomicron) 		PF08842
(Mfa2) 		5 TYR A 281
TYR A 288
ILE A 290
VAL A 305
THR A 269
 None
 1.40A 5mzrC-3gf8A:
undetectable		 5mzrC-3gf8A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7f ASPARTYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 ILE A 239
ILE A 372
VAL A 532
TYR A 523
THR A 520
 None
 1.26A 5mzrC-3i7fA:
undetectable		 5mzrC-3i7fA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irv CYSTEINE HYDROLASE

(Pseudomonas
savastanoi) 		PF00857
(Isochorismatase) 		5 ILE A  53
ILE A 169
VAL A  55
THR A 183
ILE A 184
 None
 1.16A 5mzrC-3irvA:
undetectable		 5mzrC-3irvA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgw LYSOZYME G

(Salmo salar) 		PF01464
(SLT) 		5 ILE A  69
ILE A  70
MET A  94
TYR A 185
ILE A  52
 None
 1.39A 5mzrC-3mgwA:
undetectable		 5mzrC-3mgwA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o59 DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
horikoshii) 		PF03833
(PolC_DP2) 		5 TYR X 145
ILE X 219
TYR X 146
THR X 222
ILE X 221
 None
 0.98A 5mzrC-3o59X:
undetectable		 5mzrC-3o59X:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubg NEURAL-CADHERIN

(Drosophila
melanogaster) 		PF00028
(Cadherin) 		5 TYR A 685
ILE A 699
ILE A 705
VAL A 727
ILE A 671
 None
 1.28A 5mzrC-3ubgA:
undetectable		 5mzrC-3ubgA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyh LYSOZYME G

(Struthio
camelus) 		PF01464
(SLT) 		5 ILE A  69
ILE A  70
MET A  94
TYR A 185
ILE A  52
 None
 1.28A 5mzrC-3wyhA:
undetectable		 5mzrC-3wyhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzy EXODEOXYRIBONUCLEASE
10

(Escherichia
coli) 		PF00929
(RNase_T) 		5 PRO A  90
ILE A  16
ILE A  19
VAL A  88
ILE A   5
 None
 1.35A 5mzrC-4fzyA:
undetectable		 5mzrC-4fzyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN

(Clostridium
perfringens) 		PF12849
(PBP_like_2) 		5 TYR A 133
TYR A 202
ILE A 189
ILE A 203
VAL A 153
 None
 1.40A 5mzrC-4gd5A:
undetectable		 5mzrC-4gd5A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv8 DUTPASE

(Staphylococcus
virus 11) 		PF00692
(dUTPase) 		5 TYR A 126
ILE A 110
ILE A 128
VAL A  67
ILE A  90
 None
 1.13A 5mzrC-4gv8A:
undetectable		 5mzrC-4gv8A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifs FACT COMPLEX SUBUNIT
SSRP1

(Homo sapiens) 		PF08512
(Rtt106) 		5 TYR A 214
TYR A 232
ILE A 263
ILE A 234
ILE A 257
 None
 1.36A 5mzrC-4ifsA:
undetectable		 5mzrC-4ifsA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jys PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		5 ILE A  99
ILE A 150
VAL A 183
TYR A  88
ILE A 148
 None
 1.22A 5mzrC-4jysA:
undetectable		 5mzrC-4jysA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m00 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		5 TYR A 446
ILE A 332
MET A 471
VAL A 316
ILE A 433
 None
 1.02A 5mzrC-4m00A:
undetectable		 5mzrC-4m00A:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkq MONALYSIN

(Pseudomonas
entomophila) 		no annotation 5 TYR A  96
TYR A 176
ILE A 224
THR A  99
ILE A 100
 None
 1.12A 5mzrC-4mkqA:
undetectable		 5mzrC-4mkqA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfitobacterium
hafniense) 		PF13458
(Peripla_BP_6) 		5 TYR A 177
TYR A 145
ILE A 200
ILE A 198
ILE A 220
 None
 1.17A 5mzrC-4mlcA:
undetectable		 5mzrC-4mlcA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o87 N-TAGGED NUCLEASE

(Millerozyma
acaciae) 		no annotation 5 PRO A   3
TYR A  83
ILE A  84
ILE A  80
THR A   5
 None
 1.07A 5mzrC-4o87A:
undetectable		 5mzrC-4o87A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN

(Clostridium
perfringens) 		PF12849
(PBP_like_2) 		5 TYR A 103
TYR A 172
ILE A 159
ILE A 173
VAL A 123
 None
 1.41A 5mzrC-4q8rA:
undetectable		 5mzrC-4q8rA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxz UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF14183
(YwpF) 		5 TYR A  55
ILE A  94
ILE A  85
MET A  92
THR A  51
 None
 1.41A 5mzrC-4qxzA:
undetectable		 5mzrC-4qxzA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8b EXO-XYLOGLUCANASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		5 ILE A 428
ILE A 467
VAL A 336
TYR A 229
ILE A 144
 None
 1.34A 5mzrC-4w8bA:
undetectable		 5mzrC-4w8bA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 TYR A 618
TYR A 622
ILE A 555
TYR A 620
ILE A 629
 None
 1.31A 5mzrC-4xeuA:
undetectable		 5mzrC-4xeuA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk1 PHOSPHOSERINE
AMINOTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00266
(Aminotran_5) 		5 PRO A 163
TYR A 148
ILE A  98
VAL A 146
THR A 165
 None
 1.37A 5mzrC-4xk1A:
undetectable		 5mzrC-4xk1A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
NORC-LIKE PROTEIN

(Roseobacter
denitrificans) 		PF00034
(Cytochrom_C)
PF00115
(COX1) 		5 PRO A 253
TYR B  35
ILE B  36
TYR A 247
ILE A 250
 None
 1.32A 5mzrC-4xydA:
2.2		 5mzrC-4xydA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9s EPOXIDE HYDROLASE

(Solanum
tuberosum) 		PF00561
(Abhydrolase_1) 		5 TYR A 190
PRO A 188
ILE A 148
TYR A 154
ILE A 155
 None
 1.10A 5mzrC-4y9sA:
undetectable		 5mzrC-4y9sA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		7 PRO A 120
ILE A 208
ILE A 209
MET A 212
TYR A 261
THR A 262
ILE A 265
 None
 0.81A 5mzrC-4yeuA:
19.7		 5mzrC-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 TYR A 204
ILE A 208
ILE A 209
MET A 212
THR A 262
 None
 0.92A 5mzrC-4yeuA:
19.7		 5mzrC-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 TYR A 204
ILE A 208
ILE A 209
MET A 212
VAL A 249
 None
 1.15A 5mzrC-4yeuA:
19.7		 5mzrC-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PRO A 338
TYR A 458
ILE A 459
TYR A 337
THR A 336
 None
 1.43A 5mzrC-4ynuA:
undetectable		 5mzrC-4ynuA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zba PCURE2P8

(Phanerochaete
chrysosporium) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ILE A  92
ILE A 171
MET A 166
THR A 208
ILE A 209
 None
 1.22A 5mzrC-4zbaA:
1.9		 5mzrC-4zbaA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cag UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF17145
(DUF5119) 		5 TYR A  84
PRO A  58
VAL A  79
TYR A  57
ILE A  55
 None
 1.24A 5mzrC-5cagA:
undetectable		 5mzrC-5cagA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 ILE A 403
ILE A 420
VAL A 417
THR A 481
ILE A 480
 None
 1.46A 5mzrC-5d6nA:
undetectable		 5mzrC-5d6nA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 ILE A 403
ILE A 420
VAL A 417
THR A 481
ILE A 480
 None
None
None
None
5SV  A 701 (-3.6A)
 1.33A 5mzrC-5ey8A:
undetectable		 5mzrC-5ey8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g37 41.9 KDA
INSECTICIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 ILE A 256
ILE A 193
VAL A 258
THR A 272
ILE A 275
 None
 1.13A 5mzrC-5g37A:
undetectable		 5mzrC-5g37A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwj DNA TOPOISOMERASE
2-BETA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 TYR A 534
ILE A 523
ILE A 526
VAL A 509
ILE A 573
 None
 1.29A 5mzrC-5gwjA:
1.1		 5mzrC-5gwjA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		5 TYR A 142
ILE A 216
TYR A 143
THR A 219
ILE A 218
 None
 0.91A 5mzrC-5ijlA:
undetectable		 5mzrC-5ijlA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix1 MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
3

(Mus musculus) 		PF07496
(zf-CW)
PF13589
(HATPase_c_3) 		5 ILE A 347
ILE A 315
MET A 317
THR A 370
ILE A 371
 None
 1.38A 5mzrC-5ix1A:
undetectable		 5mzrC-5ix1A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8q CYSTEINE DESULFURASE
SUFS

(Bacillus
subtilis) 		PF00266
(Aminotran_5) 		5 ILE A   3
ILE A   6
MET A   1
TYR A 380
ILE A 299
 None
 1.03A 5mzrC-5j8qA:
undetectable		 5mzrC-5j8qA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		5 TYR B1837
ILE B1771
VAL B1773
TYR B1786
ILE B1790
 None
 1.39A 5mzrC-5k8dB:
undetectable		 5mzrC-5k8dB:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8s CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT

(Plasmodium
falciparum) 		PF00027
(cNMP_binding) 		5 ILE A 413
MET A 316
VAL A 324
TYR A 374
ILE A 312
 None
 1.43A 5mzrC-5k8sA:
undetectable		 5mzrC-5k8sA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5j 30S RIBOSOMAL
PROTEIN S2

(Mycolicibacterium
smegmatis) 		PF00318
(Ribosomal_S2) 		5 ILE V 186
ILE V 200
VAL V 164
THR V 214
ILE V 217
 None
 1.40A 5mzrC-5o5jV:
undetectable		 5mzrC-5o5jV:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 TYR T 313
ILE T 354
ILE T 310
VAL T 325
TYR T 238
 None
 1.26A 5mzrC-5ojsT:
undetectable		 5mzrC-5ojsT:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tum TETRACYCLINE
DESTRUCTASE TET(56)

(Legionella
longbeachae) 		PF01494
(FAD_binding_3) 		5 TYR A 149
ILE A 127
ILE A 162
VAL A 139
ILE A 284
 None
 1.42A 5mzrC-5tumA:
1.5		 5mzrC-5tumA:
10.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 10 TYR C 119
PRO C 120
TYR C 197
ILE C 201
ILE C 202
MET C 205
VAL C 242
TYR C 254
THR C 255
ILE C 258
 None
 0.51A 5mzrC-5v6nC:
35.9		 5mzrC-5v6nC:
97.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf6 SINGLE CHAIN
VARIABLE FRAGMENT

(Gallus gallus) 		no annotation 5 PRO A  41
TYR A 218
ILE A 160
TYR A  32
ILE A 232
 None
 1.29A 5mzrC-5vf6A:
undetectable		 5mzrC-5vf6A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vu2 E2 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		no annotation 5 TYR Q 363
ILE Q 356
ILE Q 355
THR Q 367
ILE Q 370
 None
 1.04A 5mzrC-5vu2Q:
undetectable		 5mzrC-5vu2Q:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpi HSVA

(Erwinia
amylovora) 		no annotation 5 PRO A 273
ILE A 212
MET A 207
VAL A 262
ILE A 366
 PRO  A 273 ( 1.1A)
ILE  A 212 ( 0.6A)
MET  A 207 ( 0.0A)
VAL  A 262 ( 0.6A)
ILE  A 366 ( 0.7A)
 1.40A 5mzrC-5wpiA:
undetectable		 5mzrC-5wpiA:
14.32