SIMILAR PATTERNS OF AMINO ACIDS FOR 5MZP_A_CFFA2401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE

(Thermococcus
profundus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ILE A 338
VAL A 291
GLU A 201
LEU A 235
ILE A 196
 None
 1.09A 5mzpA-1euzA:
undetectable		 5mzpA-1euzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		5 ILE C 114
VAL C  93
MET C 122
LEU C 157
ILE C 134
 None
 1.29A 5mzpA-1sxjC:
1.8		 5mzpA-1sxjC:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axp HYPOTHETICAL PROTEIN
BSU20280

(Bacillus
subtilis) 		PF02223
(Thymidylate_kin) 		5 ILE A  60
VAL A  64
MET A 136
LEU A 141
ILE A  92
 None
 1.38A 5mzpA-2axpA:
undetectable		 5mzpA-2axpA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kjg ARCHAEAL PROTEIN
SSO6904

(Sulfolobus
solfataricus) 		no annotation 5 ILE A  56
GLU A  61
LEU A  12
MET A  65
ILE A  66
 None
 1.39A 5mzpA-2kjgA:
undetectable		 5mzpA-2kjgA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 ILE A  61
VAL A 144
GLU A 201
LEU A  47
ILE A  43
 None
 1.34A 5mzpA-2qbyA:
undetectable		 5mzpA-2qbyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp4 BILE SALT
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 ILE A  32
PHE A 109
MET A 173
LEU A  40
ILE A  38
 None
 1.12A 5mzpA-2qp4A:
undetectable		 5mzpA-2qp4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5q SSO1986

(Sulfolobus
solfataricus) 		no annotation 5 ILE A  29
VAL A 157
GLU A  65
LEU A 145
ILE A  15
 None
 1.43A 5mzpA-2x5qA:
undetectable		 5mzpA-2x5qA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7i MEVALONATE KINASE

(Staphylococcus
aureus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A  16
VAL A  30
MET A 174
LEU A 170
ILE A 219
 None
 1.20A 5mzpA-2x7iA:
undetectable		 5mzpA-2x7iA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2

(Methanocaldococcus
jannaschii) 		PF00155
(Aminotran_1_2) 		5 ILE A 346
VAL A 293
GLU A 315
LEU A 368
ILE A 364
 None
 1.35A 5mzpA-2z61A:
undetectable		 5mzpA-2z61A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd7 FUSION COMPLEX OF
CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR, RESIDUES
1193-1427 AND
MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK,
RESIDUES 219-371

(Escherichia
coli;
Homo sapiens) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 ILE A1554
VAL A1507
MET A1469
LEU A1451
ILE A1494
 None
 1.41A 5mzpA-3gd7A:
undetectable		 5mzpA-3gd7A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd7 FUSION COMPLEX OF
CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR, RESIDUES
1193-1427 AND
MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK,
RESIDUES 219-371

(Escherichia
coli;
Homo sapiens) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 ILE A1554
VAL A1507
MET A1469
LEU A1492
ILE A1494
 None
 1.15A 5mzpA-3gd7A:
undetectable		 5mzpA-3gd7A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijl MUCONATE
CYCLOISOMERASE

(Bacteroides
thetaiotaomicron) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A  78
VAL A 149
MET A 305
LEU A 124
ILE A 123
 None
 1.40A 5mzpA-3ijlA:
undetectable		 5mzpA-3ijlA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ja6 CHEMOTAXIS PROTEIN
CHEW

(Escherichia
coli) 		PF01584
(CheW) 		5 ILE A  82
VAL A  62
GLU A  31
LEU A  55
ILE A  34
 None
 1.12A 5mzpA-3ja6A:
undetectable		 5mzpA-3ja6A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		5 ILE A 149
VAL A 117
PHE A  70
GLU A  69
ASN A 164
 None
 1.39A 5mzpA-3q9oA:
undetectable		 5mzpA-3q9oA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ILE A  66
PHE A 168
MET A 177
LEU A 249
ASN A 253
ILE A 274
 UKA  A1200 (-4.1A)
UKA  A1200 (-3.4A)
UKA  A1200 (-4.8A)
UKA  A1200 (-4.9A)
UKA  A1200 (-3.4A)
UKA  A1200 (-4.9A)
 0.46A 5mzpA-3qakA:
33.3		 5mzpA-3qakA:
69.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 VAL A  84
PHE A 168
MET A 177
LEU A 249
ASN A 253
ILE A 274
 None
UKA  A1200 (-3.4A)
UKA  A1200 (-4.8A)
UKA  A1200 (-4.9A)
UKA  A1200 (-3.4A)
UKA  A1200 (-4.9A)
 0.86A 5mzpA-3qakA:
33.3		 5mzpA-3qakA:
69.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb9 DNA POLYMERASE III
SUBUNIT BETA

(Mycobacterium
tuberculosis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 ILE A 148
VAL A 206
GLU A 213
ASN A  32
ILE A 242
 None
 1.16A 5mzpA-3rb9A:
undetectable		 5mzpA-3rb9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK

(Escherichia
coli) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 ILE A 345
VAL A 298
MET A 260
LEU A 242
ILE A 285
 None
 1.33A 5mzpA-3rlfA:
undetectable		 5mzpA-3rlfA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK

(Escherichia
coli) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 ILE A 345
VAL A 298
MET A 260
LEU A 283
ILE A 285
 None
 1.10A 5mzpA-3rlfA:
undetectable		 5mzpA-3rlfA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Saccharomyces
cerevisiae) 		PF10156
(Med17) 		5 ILE Q 467
VAL Q 391
GLU Q 448
MET Q 442
ILE Q 545
 None
 1.47A 5mzpA-4h62Q:
undetectable		 5mzpA-4h62Q:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		5 ILE A 389
VAL A 497
GLU A 501
LEU A 509
ILE A 510
 None
 0.98A 5mzpA-4qlbA:
2.0		 5mzpA-4qlbA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM3

(Methanocaldococcus
jannaschii) 		PF03787
(RAMPs) 		5 ILE C  59
VAL C 161
GLU C 185
LEU C 234
ILE C 178
 None
 1.46A 5mzpA-4qtsC:
undetectable		 5mzpA-4qtsC:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewq AMIDASE

(Bacillus
anthracis) 		PF01425
(Amidase) 		5 VAL A 111
GLU A 100
LEU A  46
ASN A 104
ILE A  49
 None
 1.24A 5mzpA-5ewqA:
undetectable		 5mzpA-5ewqA:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g53 ADENOSINE RECEPTOR
A2A

(Homo sapiens) 		PF00001
(7tm_1) 		8 ILE A  66
PHE A 168
GLU A 169
MET A 177
LEU A 249
ASN A 253
MET A 270
ILE A 274
 None
NEC  A 400 (-3.6A)
NEC  A 400 (-4.0A)
NEC  A 400 (-4.8A)
NEC  A 400 ( 4.6A)
NEC  A 400 (-3.3A)
None
NEC  A 400 (-4.6A)
 0.48A 5mzpA-5g53A:
31.7		 5mzpA-5g53A:
70.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g53 ADENOSINE RECEPTOR
A2A

(Homo sapiens) 		PF00001
(7tm_1) 		8 VAL A  84
PHE A 168
GLU A 169
MET A 177
LEU A 249
ASN A 253
MET A 270
ILE A 274
 None
NEC  A 400 (-3.6A)
NEC  A 400 (-4.0A)
NEC  A 400 (-4.8A)
NEC  A 400 ( 4.6A)
NEC  A 400 (-3.3A)
None
NEC  A 400 (-4.6A)
 0.82A 5mzpA-5g53A:
31.7		 5mzpA-5g53A:
70.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 ILE e 271
VAL e 320
GLU e 350
LEU e 393
ILE e 395
 None
 1.42A 5mzpA-5gw5e:
undetectable		 5mzpA-5gw5e:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzd N-ACETYLNEURAMINATE
LYASE

(Staphylococcus
aureus) 		PF00701
(DHDPS) 		5 ILE A 242
GLU A  38
LEU A 259
ASN A  33
ILE A 258
 None
 1.46A 5mzpA-5kzdA:
1.0		 5mzpA-5kzdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 VAL A1369
PHE A1324
MET A1362
LEU A1345
ILE A1341
 None
 1.46A 5mzpA-5me3A:
1.7		 5mzpA-5me3A:
15.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		7 ILE A1174
VAL A1192
PHE A1276
MET A1285
LEU A1355
ASN A1359
ILE A1379
 8K8  A2001 ( 4.0A)
8K8  A2001 ( 4.1A)
8K8  A2001 ( 3.4A)
8K8  A2001 ( 4.5A)
8K8  A2001 ( 4.3A)
8K8  A2001 ( 3.1A)
8K8  A2001 ( 4.2A)
 0.73A 5mzpA-5n2sA:
34.8		 5mzpA-5n2sA:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uen ADENOSINE RECEPTOR
A1,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A1

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		6 VAL A  87
PHE A 171
MET A 180
LEU A 250
ASN A 254
ILE A 274
 DU1  A1201 (-4.7A)
DU1  A1201 (-3.5A)
DU1  A1201 (-3.4A)
DU1  A1201 (-4.4A)
DU1  A1201 (-3.1A)
DU1  A1201 (-4.3A)
 0.58A 5mzpA-5uenA:
41.8		 5mzpA-5uenA:
64.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wuj FLAGELLAR M-RING
PROTEIN
FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Helicobacter
pylori) 		no annotation 5 ILE A 537
PHE B  71
MET B  18
LEU A 551
ILE A 548
 None
 1.49A 5mzpA-5wujA:
undetectable		 5mzpA-5wujA:
7.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A

(Escherichia
coli;
Homo sapiens) 		no annotation 9 ILE A  66
VAL A  84
PHE A 168
GLU A 169
MET A 177
LEU A 249
ASN A 253
MET A 270
ILE A 274
 None
None
ZMA  A1201 (-3.5A)
ZMA  A1201 (-4.1A)
None
ZMA  A1201 (-4.1A)
ZMA  A1201 (-3.2A)
ZMA  A1201 (-4.8A)
ZMA  A1201 (-4.8A)
 0.32A 5mzpA-6aqfA:
50.9		 5mzpA-6aqfA:
98.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1

(Homo sapiens) 		no annotation 7 ILE R  69
VAL R  87
PHE R 171
MET R 180
LEU R 250
ASN R 254
ILE R 274
 None
ADN  R 400 (-4.8A)
ADN  R 400 (-3.8A)
ADN  R 400 (-4.6A)
ADN  R 400 (-4.5A)
ADN  R 400 (-2.9A)
ADN  R 400 ( 4.9A)
 0.97A 5mzpA-6d9hR:
31.0		 5mzpA-6d9hR:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1

(Homo sapiens) 		no annotation 5 PHE R 171
GLU R 172
MET R 180
LEU R 250
ASN R 254
 ADN  R 400 (-3.8A)
ADN  R 400 (-3.5A)
ADN  R 400 (-4.6A)
ADN  R 400 (-4.5A)
ADN  R 400 (-2.9A)
 1.02A 5mzpA-6d9hR:
31.0		 5mzpA-6d9hR:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpc PRO-PRO
ENDOPEPTIDASE

(Paenibacillus
alvei) 		no annotation 5 ILE A 136
VAL A 143
GLU A  57
LEU A  36
ILE A  74
 None
 1.26A 5mzpA-6fpcA:
undetectable		 5mzpA-6fpcA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdg TRXA,ADENOSINE
RECEPTOR A2A

(Escherichia
coli;
Homo sapiens) 		no annotation 6 ILE A  66
MET A 177
LEU A 249
ASN A 253
MET A 270
ILE A 274
 None
NEC  A 400 (-4.3A)
NEC  A 400 (-4.9A)
NEC  A 400 (-3.5A)
None
NEC  A 400 (-4.2A)
 0.41A 5mzpA-6gdgA:
29.4		 5mzpA-6gdgA:
12.87