SIMILAR PATTERNS OF AMINO ACIDS FOR 5MZJ_A_TEPA2401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecx AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00266
(Aminotran_5) 		4 LEU A 276
PHE A 365
LEU A 307
ILE A 372
 None
 0.88A 5mzjA-1ecxA:
0.0		 5mzjA-1ecxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6d UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Escherichia
coli) 		PF02350
(Epimerase_2) 		4 LEU A 247
PHE A 222
LEU A 259
ILE A 258
 None
 0.85A 5mzjA-1f6dA:
undetectable		 5mzjA-1f6dA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv6 ALGINATE LYASE

(Sphingomonas
sp.) 		PF05426
(Alginate_lyase) 		4 LEU A 117
PHE A  90
GLU A  91
LEU A 126
 None
 0.87A 5mzjA-1hv6A:
0.5		 5mzjA-1hv6A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jif BLEOMYCIN-BINDING
PROTEIN

(Streptomyces
verticillus) 		no annotation 4 LEU A  27
PHE A 118
LEU A  48
ILE A  46
 None
 0.88A 5mzjA-1jifA:
undetectable		 5mzjA-1jifA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpl ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3

(Homo sapiens) 		PF00790
(VHS) 		4 LEU A  69
PHE A  89
LEU A 118
ILE A 131
 None
 0.97A 5mzjA-1jplA:
2.1		 5mzjA-1jplA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 LEU A 264
PHE A 244
MET A 228
ILE A 254
 None
 0.96A 5mzjA-1k32A:
2.4		 5mzjA-1k32A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		4 GLU A  85
MET A 310
LEU A 266
ILE A 286
 None
 0.94A 5mzjA-1nbwA:
0.0		 5mzjA-1nbwA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfh CONSERVED
HYPOTHETICAL PROTEIN
AF1956

(Archaeoglobus
fulgidus) 		PF01918
(Alba) 		4 LEU A  21
GLU A  48
LEU A  87
ILE A  33
 None
 0.93A 5mzjA-1nfhA:
undetectable		 5mzjA-1nfhA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rii 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Mycobacterium
tuberculosis) 		PF00300
(His_Phos_1) 		4 LEU A 217
PHE A 164
LEU A   9
ILE A 180
 None
 0.94A 5mzjA-1riiA:
undetectable		 5mzjA-1riiA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		4 LEU A 223
PHE A  61
LEU A  29
ILE A  34
 None
 0.92A 5mzjA-1vbmA:
0.3		 5mzjA-1vbmA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpb PUTATIVE MODULATOR
OF DNA GYRASE

(Bacteroides
thetaiotaomicron) 		PF01523
(PmbA_TldD) 		4 LEU A 267
PHE A 310
LEU A 248
MET A 342
 None
 0.98A 5mzjA-1vpbA:
undetectable		 5mzjA-1vpbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE

(Escherichia
virus T4) 		PF11440
(AGT) 		4 LEU A1061
PHE A1006
LEU A1100
ILE A1103
 None
 1.01A 5mzjA-1xv5A:
0.0		 5mzjA-1xv5A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0t DUAL SPECIFICITY
PHOSPHATASE 26

(Homo sapiens) 		PF00782
(DSPc) 		4 LEU A 167
GLU A  64
LEU A 141
ILE A 148
 None
 0.61A 5mzjA-2e0tA:
undetectable		 5mzjA-2e0tA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erh COLICIN E7

(Escherichia
coli) 		no annotation 4 LEU B 543
GLU B 501
LEU B 484
ILE B 480
 None
 0.98A 5mzjA-2erhB:
undetectable		 5mzjA-2erhB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  39
PHE A  89
LEU A  70
ILE A 113
 None
 1.02A 5mzjA-2hneA:
undetectable		 5mzjA-2hneA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqc FANCONI ANEMIA GROUP
F PROTEIN

(Homo sapiens) 		PF11107
(FANCF) 		4 LEU A 260
PHE A 248
LEU A 209
ILE A 205
 None
 0.85A 5mzjA-2iqcA:
undetectable		 5mzjA-2iqcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 381
GLU A 450
LEU A 396
ILE A 447
 None
 0.88A 5mzjA-2ji9A:
undetectable		 5mzjA-2ji9A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lvi POLCALCIN PHL P 7

(Phleum pratense) 		PF13499
(EF-hand_7) 		4 LEU A  28
PHE A  62
MET A  70
ILE A  54
 None
 0.82A 5mzjA-2lviA:
undetectable		 5mzjA-2lviA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odh R.BCNI

(Brevibacillus
centrosporus) 		PF15515
(MvaI_BcnI) 		4 LEU A 237
GLU A   8
LEU A  53
ILE A  51
 None
 1.00A 5mzjA-2odhA:
undetectable		 5mzjA-2odhA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp4 BILE SALT
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 PHE A 109
MET A 173
LEU A  40
ILE A  38
 None
 0.91A 5mzjA-2qp4A:
undetectable		 5mzjA-2qp4A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 353
PHE A 168
LEU A 159
ILE A 234
 None
 0.97A 5mzjA-2qygA:
undetectable		 5mzjA-2qygA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0f WSAF

(Geobacillus
stearothermophilus) 		no annotation 4 LEU A 339
GLU A 241
LEU A 311
ILE A 280
 None
 0.97A 5mzjA-2x0fA:
undetectable		 5mzjA-2x0fA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		4 LEU A 801
PHE A 882
MET A 712
ILE A 893
 None
 0.96A 5mzjA-2x6kA:
2.4		 5mzjA-2x6kA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 LEU A  59
LEU A  77
MET A 311
ILE A  75
 None
 0.87A 5mzjA-2y24A:
undetectable		 5mzjA-2y24A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y96 DUAL SPECIFICITY
PHOSPHATASE DUPD1

(Homo sapiens) 		PF00782
(DSPc) 		4 LEU A 162
GLU A  57
LEU A 136
ILE A 143
 None
 0.71A 5mzjA-2y96A:
undetectable		 5mzjA-2y96A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		4 LEU A 257
PHE A 353
LEU A 329
ILE A 332
 HAS  A1016 ( 3.9A)
None
None
None
 0.84A 5mzjA-2yevA:
8.9		 5mzjA-2yevA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 485
GLU A 451
LEU A 469
ILE A 443
 None
 0.75A 5mzjA-3ciyA:
undetectable		 5mzjA-3ciyA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr3 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE, ADP-BINDING
SUBUNIT DHAL

(Lactococcus
lactis) 		PF02734
(Dak2) 		4 LEU A  71
MET A  45
LEU A  52
ILE A  63
 None
 0.93A 5mzjA-3cr3A:
2.7		 5mzjA-3cr3A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1) 		no annotation 4 LEU A 762
MET A 754
LEU A 791
ILE A 784
 None
 0.97A 5mzjA-3f95A:
undetectable		 5mzjA-3f95A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff0 PHENAZINE
BIOSYNTHESIS PROTEIN
PHZB 2

(Pseudomonas
aeruginosa) 		PF03284
(PHZA_PHZB) 		4 LEU A  50
MET A 139
ASN A 119
ILE A 107
 UNL  A 163 ( 4.0A)
None
None
None
 0.95A 5mzjA-3ff0A:
undetectable		 5mzjA-3ff0A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00579
(tRNA-synt_1b) 		4 LEU A  97
PHE A  34
GLU A  35
ILE A  26
 None
 0.90A 5mzjA-3focA:
undetectable		 5mzjA-3focA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7q VALINE-PYRUVATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		4 LEU A  91
LEU A 243
ASN A 219
ILE A 241
 None
 0.89A 5mzjA-3g7qA:
undetectable		 5mzjA-3g7qA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn2 2-DEHYDROPANTOATE
2-REDUCTASE

(Geobacter
metallireducens) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 LEU A 100
PHE A 164
LEU A  70
ILE A   3
 None
 1.02A 5mzjA-3hn2A:
2.5		 5mzjA-3hn2A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jup PHENAZINE
BIOSYNTHESIS PROTEIN
A/B

(Burkholderia
lata) 		PF03284
(PHZA_PHZB) 		4 LEU A  53
MET A 142
ASN A 122
ILE A 110
 AKD  A 500 ( 4.2A)
None
None
None
 0.91A 5mzjA-3jupA:
undetectable		 5mzjA-3jupA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		4 LEU A 308
LEU A 242
MET A 233
ILE A 234
 None
 0.75A 5mzjA-3k1jA:
undetectable		 5mzjA-3k1jA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6d PUTATIVE
OXIDOREDUCTASE

(Pseudomonas
putida) 		PF03446
(NAD_binding_2) 		4 LEU A 111
GLU A  81
LEU A  73
ILE A  15
 None
 0.86A 5mzjA-3l6dA:
undetectable		 5mzjA-3l6dA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltj ALPHAREP-4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		4 LEU A  59
GLU A  84
LEU A 105
ILE A 108
 None
 0.96A 5mzjA-3ltjA:
undetectable		 5mzjA-3ltjA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwn PHYCOERYTHRIN

(Phormidium
tenue) 		PF00502
(Phycobilisome) 		4 LEU A1138
MET A1144
LEU A1044
ILE A1093
 CYC  A3002 (-4.0A)
None
CYC  A3002 (-3.9A)
None
 0.98A 5mzjA-3mwnA:
undetectable		 5mzjA-3mwnA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n53 RESPONSE REGULATOR
RECEIVER MODULATED
DIGUANYLATE CYCLASE

(Pelobacter
carbinolicus) 		PF00072
(Response_reg) 		4 LEU A  37
LEU A  50
MET A  52
ILE A  54
 None
 1.02A 5mzjA-3n53A:
undetectable		 5mzjA-3n53A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH) 		4 LEU A 335
GLU A 256
LEU A 280
ILE A 290
 LEU  A 335 ( 0.6A)
GLU  A 256 ( 0.6A)
LEU  A 280 ( 0.6A)
ILE  A 290 (-0.7A)
 0.99A 5mzjA-3o96A:
2.3		 5mzjA-3o96A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm9 PUTATIVE
OXIDOREDUCTASE

(Rhodopseudomonas
palustris) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 LEU A  12
PHE A  20
LEU A  77
ILE A  99
 None
 0.90A 5mzjA-3pm9A:
undetectable		 5mzjA-3pm9A:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 LEU A  85
PHE A 168
MET A 177
LEU A 249
ASN A 253
ILE A 274
 UKA  A1200 (-4.8A)
UKA  A1200 (-3.4A)
UKA  A1200 (-4.8A)
UKA  A1200 (-4.9A)
UKA  A1200 (-3.4A)
UKA  A1200 (-4.9A)
 0.60A 5mzjA-3qakA:
33.4		 5mzjA-3qakA:
69.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		4 LEU A 460
LEU A  74
MET A  72
ILE A  80
 None
 0.99A 5mzjA-3t5tA:
undetectable		 5mzjA-3t5tA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 LEU A1171
PHE A1111
LEU A1073
ILE A1071
 None
 0.94A 5mzjA-3u44A:
2.8		 5mzjA-3u44A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uca GERANYLTRANSTRANSFER
ASE

(Clostridium
perfringens) 		PF00348
(polyprenyl_synt) 		4 LEU A 177
PHE A 259
GLU A 263
ILE A 226
 None
 0.84A 5mzjA-3ucaA:
3.4		 5mzjA-3ucaA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4k D-AMINO-ACID OXIDASE

(Homo sapiens) 		PF01266
(DAO) 		4 LEU A 296
GLU A 169
LEU A 189
ILE A   6
 None
None
FAD  A 401 ( 4.9A)
None
 1.01A 5mzjA-3w4kA:
undetectable		 5mzjA-3w4kA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162

(Thermotoga
maritima) 		PF12706
(Lactamase_B_2) 		4 PHE A  96
MET A  88
LEU A  45
ILE A  19
 None
 0.86A 5mzjA-3x2zA:
undetectable		 5mzjA-3x2zA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 LEU B1963
PHE B2005
LEU B1882
ILE B1991
 None
 0.78A 5mzjA-3zefB:
3.4		 5mzjA-3zefB:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 PHE A 834
LEU A 860
ASN A 631
ILE A 683
 None
 0.91A 5mzjA-3zifA:
undetectable		 5mzjA-3zifA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2f PUTATIVE ANTIGEN P35

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		4 LEU A 178
GLU A 244
LEU A 259
ILE A 164
 None
 0.83A 5mzjA-4b2fA:
2.9		 5mzjA-4b2fA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3g DNA-BINDING PROTEIN
SMUBP-2

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		4 LEU A 166
GLU A 382
LEU A 397
ILE A 374
 None
 0.99A 5mzjA-4b3gA:
2.1		 5mzjA-4b3gA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		4 PHE A 373
MET A 425
LEU A 418
ILE A 363
 None
 0.96A 5mzjA-4be9A:
undetectable		 5mzjA-4be9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 LEU A 393
PHE A 196
LEU A 234
ILE A  74
 None
 0.87A 5mzjA-4bjpA:
undetectable		 5mzjA-4bjpA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		4 LEU A 518
PHE A 597
MET A 846
LEU A 508
 None
 0.84A 5mzjA-4czwA:
undetectable		 5mzjA-4czwA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dy0 GLIA-DERIVED NEXIN

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A 371
GLU A 224
ASN A 365
MET A 262
ILE A 258
 None
 1.19A 5mzjA-4dy0A:
undetectable		 5mzjA-4dy0A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2a PUTATIVE
ACETYLTRANSFERASE

(Streptococcus
mutans) 		PF13673
(Acetyltransf_10) 		4 LEU A 130
PHE A 113
GLU A 114
LEU A 142
 None
 0.92A 5mzjA-4e2aA:
undetectable		 5mzjA-4e2aA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eps HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF13149
(Mfa_like_1) 		4 LEU A 137
MET A 122
ASN A  86
ILE A  70
 None
None
GOL  A 629 (-3.8A)
None
 0.94A 5mzjA-4epsA:
undetectable		 5mzjA-4epsA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hti RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2

(Homo sapiens) 		PF11548
(Receptor_IA-2) 		4 LEU A 536
GLU A 582
LEU A 529
ILE A 514
 None
 1.02A 5mzjA-4htiA:
undetectable		 5mzjA-4htiA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 LEU A 901
GLU A 812
LEU A 860
ILE A 807
 None
 1.00A 5mzjA-4j3bA:
undetectable		 5mzjA-4j3bA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpk ENOYL-COA
HYDRATASE/ISOMERASE

(Shewanella
pealeana) 		PF00378
(ECH_1) 		4 LEU A 130
PHE A  41
MET A  49
LEU A 101
 None
 0.92A 5mzjA-4kpkA:
undetectable		 5mzjA-4kpkA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0j DNA HELICASE I

(Escherichia
coli) 		no annotation 4 LEU A 704
MET A 654
LEU A 681
ILE A 695
 None
 0.98A 5mzjA-4l0jA:
undetectable		 5mzjA-4l0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 LEU B 597
PHE B 494
LEU B 609
ILE B 512
 None
 0.99A 5mzjA-4l37B:
undetectable		 5mzjA-4l37B:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6

(Saccharomyces
cerevisiae) 		PF01423
(LSM) 		4 LEU E  21
GLU E  50
LEU E  24
MET D  79
 None
 0.91A 5mzjA-4m75E:
undetectable		 5mzjA-4m75E:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjd KETOSTEROID
ISOMERASE FOLD
PROTEIN HMUK_0747

(Halomicrobium
mukohataei) 		PF12680
(SnoaL_2) 		4 LEU A  14
MET A  49
LEU A  26
ILE A 100
 None
 0.97A 5mzjA-4mjdA:
undetectable		 5mzjA-4mjdA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 LEU A 443
GLU A 429
LEU A 386
MET A 374
 None
 0.70A 5mzjA-4nenA:
undetectable		 5mzjA-4nenA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pib INCLUSION BODY
PROTEIN

(Burkholderia
thailandensis) 		PF12306
(PixA) 		4 LEU A 112
PHE A  87
LEU A  77
ILE A  75
 None
 1.01A 5mzjA-4pibA:
undetectable		 5mzjA-4pibA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmh LP04448P

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		4 PHE A 977
LEU A 947
MET A 982
ILE A 983
 None
 0.92A 5mzjA-4qmhA:
undetectable		 5mzjA-4qmhA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A3368
GLU A3333
LEU A3314
ILE A3355
 None
 0.98A 5mzjA-4rh7A:
undetectable		 5mzjA-4rh7A:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm4 CYTOCHROME P450

(Bacillus
subtilis) 		PF00067
(p450) 		4 LEU A 236
PHE A 100
LEU A 214
ILE A 213
 HEM  A 401 ( 4.1A)
None
None
None
 0.98A 5mzjA-4rm4A:
undetectable		 5mzjA-4rm4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 LEU A 202
GLU A 166
LEU A 162
ILE A 121
 None
 0.97A 5mzjA-4wp0A:
undetectable		 5mzjA-4wp0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvp BGFP-C

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		4 LEU D  23
GLU D  48
LEU D  69
ILE D  72
 None
 0.98A 5mzjA-4xvpD:
undetectable		 5mzjA-4xvpD:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		4 LEU A 304
PHE A 311
LEU A  31
ILE A 163
 None
 0.87A 5mzjA-4y9wA:
undetectable		 5mzjA-4y9wA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		4 LEU A 209
PHE A 238
MET A 105
ILE A 201
 None
 0.90A 5mzjA-5b1qA:
2.3		 5mzjA-5b1qA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c54 DIHYDRODIPICOLINATE
SYNTHASE/N-ACETYLNEU
RAMINATE LYASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		4 LEU A 104
GLU A  98
LEU A  64
ILE A  68
 None
 0.89A 5mzjA-5c54A:
undetectable		 5mzjA-5c54A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw8 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		5 LEU A 168
MET A 104
LEU A 185
ASN A 101
ILE A 160
 None
55X  A 201 (-4.3A)
None
None
None
 1.43A 5mzjA-5cw8A:
4.7		 5mzjA-5cw8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcq ARTIFICIAL REPEAT
PROTEINS (ALPHAREP3)

(synthetic
construct) 		PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		4 LEU A  53
GLU A  78
LEU A  99
ILE A 102
 None
 1.01A 5mzjA-5dcqA:
undetectable		 5mzjA-5dcqA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis GTP-BINDING NUCLEAR
PROTEIN RAN

(Homo sapiens) 		PF00071
(Ras) 		4 LEU B  50
LEU B  15
MET B  89
ILE B  87
 None
 0.98A 5mzjA-5disB:
undetectable		 5mzjA-5disB:
16.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g53 ADENOSINE RECEPTOR
A2A

(Homo sapiens) 		PF00001
(7tm_1) 		8 LEU A  85
PHE A 168
GLU A 169
MET A 177
LEU A 249
ASN A 253
MET A 270
ILE A 274
 NEC  A 400 (-4.9A)
NEC  A 400 (-3.6A)
NEC  A 400 (-4.0A)
NEC  A 400 (-4.8A)
NEC  A 400 ( 4.6A)
NEC  A 400 (-3.3A)
None
NEC  A 400 (-4.6A)
 0.58A 5mzjA-5g53A:
31.8		 5mzjA-5g53A:
70.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE

(Lactobacillus
brevis) 		no annotation 4 LEU C 198
GLU C 231
ASN C 234
ILE C 243
 None
 0.66A 5mzjA-5gp4C:
undetectable		 5mzjA-5gp4C:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtj DUAL SPECIFICITY
PROTEIN PHOSPHATASE
26

(Homo sapiens) 		PF00782
(DSPc) 		4 LEU A 167
GLU A  64
LEU A 141
ILE A 148
 None
 0.63A 5mzjA-5gtjA:
undetectable		 5mzjA-5gtjA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf7 PROTEASOME SUBUNIT
BETA TYPE-1

(Homo sapiens) 		PF00227
(Proteasome) 		4 LEU L  46
LEU L  92
ASN L 108
ILE L  95
 None
 0.96A 5mzjA-5lf7L:
undetectable		 5mzjA-5lf7L:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		4 GLU A 113
MET A 101
LEU A 145
ILE A 155
 None
 0.99A 5mzjA-5m09A:
3.7		 5mzjA-5m09A:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		4 LEU A1193
PHE A1276
MET A1285
ASN A1359
 None
8K8  A2001 ( 3.4A)
8K8  A2001 ( 4.5A)
8K8  A2001 ( 3.1A)
 0.49A 5mzjA-5n2sA:
34.7		 5mzjA-5n2sA:
37.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 PHE A1276
MET A1285
LEU A1355
ASN A1359
ILE A1379
 8K8  A2001 ( 3.4A)
8K8  A2001 ( 4.5A)
8K8  A2001 ( 4.3A)
8K8  A2001 ( 3.1A)
8K8  A2001 ( 4.2A)
 0.57A 5mzjA-5n2sA:
34.7		 5mzjA-5n2sA:
37.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		PF16679
(CDT1_C) 		4 LEU 8  20
LEU 8 118
ASN 8  50
ILE 8 198
 None
 0.97A 5mzjA-5udb8:
undetectable		 5mzjA-5udb8:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uen ADENOSINE RECEPTOR
A1,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A1

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		6 LEU A  88
PHE A 171
MET A 180
LEU A 250
ASN A 254
ILE A 274
 None
DU1  A1201 (-3.5A)
DU1  A1201 (-3.4A)
DU1  A1201 (-4.4A)
DU1  A1201 (-3.1A)
DU1  A1201 (-4.3A)
 0.74A 5mzjA-5uenA:
36.2		 5mzjA-5uenA:
64.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wql TAIL-SPECIFIC
PROTEASE

(Escherichia
coli) 		no annotation 4 LEU C 442
MET C 461
LEU C 392
ILE C 362
 None
 0.74A 5mzjA-5wqlC:
undetectable		 5mzjA-5wqlC:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
PROTEIN L29

(Spinacia
oleracea) 		PF00276
(Ribosomal_L23)
PF00831
(Ribosomal_L29) 		4 LEU Z  92
PHE U 155
LEU U 134
ILE U 176
 None
 0.95A 5mzjA-5x8tZ:
3.0		 5mzjA-5x8tZ:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 4 LEU A 356
MET A 371
LEU A 379
ILE A 410
 None
 0.89A 5mzjA-5y3jA:
undetectable		 5mzjA-5y3jA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zi9 CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Streptomyces
coelicolor) 		no annotation 4 LEU A 215
PHE A 184
LEU A 202
ILE A 200
 None
 0.74A 5mzjA-5zi9A:
undetectable		 5mzjA-5zi9A:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 4 LEU A 356
MET A 371
LEU A 379
ILE A 410
 None
 0.94A 5mzjA-5zlnA:
undetectable		 5mzjA-5zlnA:
12.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A

(Escherichia
coli;
Homo sapiens) 		no annotation 8 LEU A  85
PHE A 168
GLU A 169
MET A 177
LEU A 249
ASN A 253
MET A 270
ILE A 274
 None
ZMA  A1201 (-3.5A)
ZMA  A1201 (-4.1A)
None
ZMA  A1201 (-4.1A)
ZMA  A1201 (-3.2A)
ZMA  A1201 (-4.8A)
ZMA  A1201 (-4.8A)
 0.28A 5mzjA-6aqfA:
50.7		 5mzjA-6aqfA:
97.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0n ENVELOPE
GLYCOPROTEIN GP140

(Human
immunodeficiency
virus 1) 		no annotation 4 LEU G 259
PHE G 391
LEU G 416
ILE G 414
 None
 0.90A 5mzjA-6b0nG:
undetectable		 5mzjA-6b0nG:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1

(Homo sapiens) 		no annotation 5 LEU R  88
GLU R 172
MET R 180
LEU R 250
ASN R 254
 ADN  R 400 ( 4.5A)
ADN  R 400 (-3.5A)
ADN  R 400 (-4.6A)
ADN  R 400 (-4.5A)
ADN  R 400 (-2.9A)
 1.19A 5mzjA-6d9hR:
30.9		 5mzjA-6d9hR:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1

(Homo sapiens) 		no annotation 5 LEU R  88
MET R 180
LEU R 250
ASN R 254
ILE R 274
 ADN  R 400 ( 4.5A)
ADN  R 400 (-4.6A)
ADN  R 400 (-4.5A)
ADN  R 400 (-2.9A)
ADN  R 400 ( 4.9A)
 0.66A 5mzjA-6d9hR:
30.9		 5mzjA-6d9hR:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1

(Homo sapiens) 		no annotation 5 LEU R  88
PHE R 171
GLU R 172
MET R 180
LEU R 250
 ADN  R 400 ( 4.5A)
ADN  R 400 (-3.8A)
ADN  R 400 (-3.5A)
ADN  R 400 (-4.6A)
ADN  R 400 (-4.5A)
 1.19A 5mzjA-6d9hR:
30.9		 5mzjA-6d9hR:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1

(Homo sapiens) 		no annotation 5 LEU R  88
PHE R 171
MET R 180
LEU R 250
ILE R 274
 ADN  R 400 ( 4.5A)
ADN  R 400 (-3.8A)
ADN  R 400 (-4.6A)
ADN  R 400 (-4.5A)
ADN  R 400 ( 4.9A)
 0.83A 5mzjA-6d9hR:
30.9		 5mzjA-6d9hR:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft5 -

(-) 		no annotation 4 LEU A  59
GLU A  84
LEU A 105
ILE A 108
 None
 1.01A 5mzjA-6ft5A:
3.0		 5mzjA-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft5 -

(-) 		no annotation 4 LEU A 121
GLU A 146
LEU A 167
ILE A 170
 None
 0.97A 5mzjA-6ft5A:
3.0		 5mzjA-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdg TRXA,ADENOSINE
RECEPTOR A2A

(Escherichia
coli;
Homo sapiens) 		no annotation 6 LEU A  85
MET A 177
LEU A 249
ASN A 253
MET A 270
ILE A 274
 NEC  A 400 ( 4.5A)
NEC  A 400 (-4.3A)
NEC  A 400 (-4.9A)
NEC  A 400 (-3.5A)
None
NEC  A 400 (-4.2A)
 0.63A 5mzjA-6gdgA:
29.4		 5mzjA-6gdgA:
12.87