SIMILAR PATTERNS OF AMINO ACIDS FOR 5MXB_A_ML1A222_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6j NITROGEN REGULATORY
IIA PROTEIN

(Escherichia
coli) 		PF00359
(PTS_EIIA_2) 		5 ILE A  94
LEU A  90
GLY A  64
ALA A  98
PHE A  96
 None
 1.15A 5mxbA-1a6jA:
0.0		 5mxbA-1a6jA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		5 VAL A 193
ILE A 160
PHE A 159
GLY A 188
ALA A 190
 None
 1.18A 5mxbA-1ddkA:
0.2		 5mxbA-1ddkA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A  14
ILE A  37
LEU A 107
GLY A  20
ALA A 146
 None
None
None
FAD  A 462 (-3.7A)
FAD  A 462 (-4.7A)
 1.05A 5mxbA-1ebdA:
undetectable		 5mxbA-1ebdA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00478
(IMPDH) 		5 ILE A 355
LEU A 359
GLY A 285
ALA A 289
PHE A 288
 None
None
SO4  A 600 (-3.4A)
None
None
 1.20A 5mxbA-1eepA:
0.0		 5mxbA-1eepA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 VAL A 352
THR A 369
ILE A 367
LEU A 332
ALA A 383
 None
 0.92A 5mxbA-1fc4A:
0.5		 5mxbA-1fc4A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		5 VAL A 616
ILE A 513
ARG A 511
GLY A 622
PHE A 484
 None
 1.15A 5mxbA-1fohA:
1.0		 5mxbA-1fohA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1goj KINESIN HEAVY CHAIN

(Neurospora
crassa) 		PF00225
(Kinesin) 		5 THR A 320
ILE A 305
LEU A 303
PHE A 323
ALA A  92
 None
None
None
None
ADP  A 400 (-4.3A)
 1.19A 5mxbA-1gojA:
0.0		 5mxbA-1gojA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7y TRANSLATIONALLY
CONTROLLED TUMOR
PROTEIN

(Schizosaccharomyces
pombe) 		PF00838
(TCTP) 		5 VAL A  27
ILE A 157
GLY A 116
ALA A 114
PHE A 117
 None
 1.09A 5mxbA-1h7yA:
undetectable		 5mxbA-1h7yA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II

(Thermus
thermophilus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 336
LEU A 339
GLY A  18
ALA A  21
PHE A  22
 None
 1.08A 5mxbA-1j3nA:
0.0		 5mxbA-1j3nA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kae HISTIDINOL
DEHYDROGENASE

(Escherichia
coli) 		PF00815
(Histidinol_dh) 		5 THR A 406
ILE A 407
GLY A 399
ALA A 402
PHE A 400
 None
 1.07A 5mxbA-1kaeA:
undetectable		 5mxbA-1kaeA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8r DACHSHUND

(Homo sapiens) 		PF02437
(Ski_Sno) 		5 VAL A 198
ILE A 209
ARG A 194
GLY A 195
ALA A 196
 None
 1.00A 5mxbA-1l8rA:
undetectable		 5mxbA-1l8rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luz PROTEIN K3

(Vaccinia virus) 		PF00575
(S1) 		5 VAL A  70
ILE A  77
LEU A  30
GLY A  12
ALA A  11
 None
 1.17A 5mxbA-1luzA:
undetectable		 5mxbA-1luzA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1f INTERLEUKIN-19

(Homo sapiens) 		PF00726
(IL10) 		5 THR A 119
ILE A 122
LEU A  42
ALA A  65
PHE A  66
 None
 1.19A 5mxbA-1n1fA:
undetectable		 5mxbA-1n1fA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohf NUDAURELIA CAPENSIS
OMEGA VIRUS CAPSID
PROTEIN

(Nudaurelia
capensis omega
virus) 		PF03566
(Peptidase_A21) 		5 THR A 385
ILE A 384
LEU A 299
PHE A 371
GLY A 337
 None
 0.99A 5mxbA-1ohfA:
undetectable		 5mxbA-1ohfA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p50 ARGININE KINASE

(Limulus
polyphemus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 VAL A 283
ILE A 285
LEU A 287
PHE A 119
GLY A 345
 ADP  A 400 (-4.3A)
None
None
None
None
 1.05A 5mxbA-1p50A:
1.4		 5mxbA-1p50A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pov POLIOVIRUS NATIVE
EMPTY CAPSID (TYPE
1)

(Enterovirus C) 		PF00073
(Rhv)
PF02226
(Pico_P1A) 		5 VAL 0 177
ILE 0 322
LEU 0 155
GLY 0 297
ALA 0 195
 None
 0.99A 5mxbA-1pov0:
undetectable		 5mxbA-1pov0:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwr MANNOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
subtilis) 		PF01238
(PMI_typeI) 		5 ILE A 295
LEU A  61
GLY A  73
ALA A 298
PHE A 267
 None
 1.15A 5mxbA-1qwrA:
undetectable		 5mxbA-1qwrA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		5 ILE A 356
LEU A 352
PHE A 353
TYR A 291
ALA A 311
 None
 1.20A 5mxbA-1x1nA:
undetectable		 5mxbA-1x1nA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE 1

(Solanum
lycopersicum) 		PF01095
(Pectinesterase) 		5 VAL A 231
ILE A 197
LEU A 168
PHE A 163
GLY A 220
 None
 1.19A 5mxbA-1xg2A:
undetectable		 5mxbA-1xg2A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 VAL A 375
THR A 378
ILE A 379
GLY A 298
PHE A 300
 None
 1.15A 5mxbA-1ysjA:
undetectable		 5mxbA-1ysjA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buy PROTOCATECHUATE
3,4-DIOXYGENASE
ALPHA CHAIN

(Acinetobacter
sp. ADP1) 		PF00775
(Dioxygenase_C) 		5 VAL A  55
ILE A 187
LEU A 128
GLY A  96
ALA A  97
 None
 1.14A 5mxbA-2buyA:
undetectable		 5mxbA-2buyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct8 METHIONYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		5 VAL A 283
THR A 265
LEU A 234
GLY A 257
ALA A 285
 None
None
MSP  A 501 ( 4.6A)
MSP  A 501 (-2.9A)
None
 0.96A 5mxbA-2ct8A:
undetectable		 5mxbA-2ct8A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN

(Oligobrachia
mashikoi) 		PF00042
(Globin) 		5 LEU B   9
ARG B 122
GLY B 120
ALA B 121
PHE B 124
 None
 1.06A 5mxbA-2d2nB:
undetectable		 5mxbA-2d2nB:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG

(Mus musculus) 		PF01612
(DNA_pol_A_exo1) 		5 ILE A  94
LEU A 118
GLY A  74
ALA A 211
PHE A  75
 None
 1.02A 5mxbA-2e6mA:
undetectable		 5mxbA-2e6mA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG

(Mus musculus) 		PF01612
(DNA_pol_A_exo1) 		5 ILE A  94
LEU A 118
PHE A 106
GLY A  74
PHE A  75
 None
 1.05A 5mxbA-2e6mA:
undetectable		 5mxbA-2e6mA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Aquifex
aeolicus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL A 219
THR A 129
TYR A 320
GLY A 211
ALA A 215
 None
 0.99A 5mxbA-2ep7A:
undetectable		 5mxbA-2ep7A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbv WERNER SYNDROME
HELICASE

(Homo sapiens) 		PF01612
(DNA_pol_A_exo1) 		5 ILE A 100
LEU A 124
GLY A  80
ALA A 217
PHE A  81
 None
 1.15A 5mxbA-2fbvA:
undetectable		 5mxbA-2fbvA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbv WERNER SYNDROME
HELICASE

(Homo sapiens) 		PF01612
(DNA_pol_A_exo1) 		5 ILE A 100
LEU A 124
PHE A 112
GLY A  80
PHE A  81
 None
 1.12A 5mxbA-2fbvA:
undetectable		 5mxbA-2fbvA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Staphylococcus
aureus) 		PF01467
(CTP_transf_like) 		5 THR A  88
ILE A  89
LEU A 101
PHE A  92
GLY A   8
 None
None
None
None
DND  A 998 (-3.2A)
 0.97A 5mxbA-2h29A:
undetectable		 5mxbA-2h29A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpw GREEN FLUORESCENT
PROTEIN

(Clytia gregaria) 		PF01353
(GFP) 		5 VAL A  58
THR A  62
ILE A  63
LEU A  21
GLY A 128
 None
 1.20A 5mxbA-2hpwA:
1.1		 5mxbA-2hpwA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 THR A 249
TYR A 440
GLY A 428
ALA A 423
PHE A 429
 None
 1.02A 5mxbA-2ihtA:
undetectable		 5mxbA-2ihtA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkd TRANSLATION
INITIATION FACTOR
IF-2

(Geobacillus
stearothermophilus) 		PF00009
(GTP_EFTU) 		5 VAL A  82
ILE A 110
LEU A 136
PHE A 147
GLY A  15
 None
 1.20A 5mxbA-2lkdA:
undetectable		 5mxbA-2lkdA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A  49
LEU A 343
GLY A  64
ALA A 121
PHE A  65
 None
 1.04A 5mxbA-2og9A:
undetectable		 5mxbA-2og9A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ose PROBABLE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Mimivirus) 		PF00160
(Pro_isomerase) 		5 VAL A 168
PHE A  47
TYR A 107
ALA A  39
PHE A  40
 None
 1.13A 5mxbA-2oseA:
undetectable		 5mxbA-2oseA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		5 VAL A  94
ILE A  62
LEU A 140
GLY A 179
PHE A 178
 None
 1.16A 5mxbA-2pxjA:
undetectable		 5mxbA-2pxjA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r39 FIXG-RELATED PROTEIN

(Vibrio
parahaemolyticus) 		PF11614
(FixG_C) 		5 VAL A 438
ILE A 436
LEU A 446
GLY A 381
ALA A 380
 None
 1.13A 5mxbA-2r39A:
undetectable		 5mxbA-2r39A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7a BACTERIAL HEME
BINDING PROTEIN

(Shigella
dysenteriae) 		PF01497
(Peripla_BP_2) 		5 VAL A  28
ILE A  85
LEU A 126
ARG A  45
GLY A  43
 None
 1.06A 5mxbA-2r7aA:
undetectable		 5mxbA-2r7aA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2re3 UNCHARACTERIZED
PROTEIN

(Ruegeria
pomeroyi) 		PF06938
(DUF1285) 		5 ILE A  88
LEU A  70
PHE A  77
GLY A  48
ALA A  45
 None
 1.12A 5mxbA-2re3A:
undetectable		 5mxbA-2re3A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rha TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Novosphingobium
aromaticivorans) 		PF14514
(TetR_C_9) 		5 THR A 201
ILE A 205
PHE A 204
GLY A 168
ALA A 170
 None
 1.03A 5mxbA-2rhaA:
undetectable		 5mxbA-2rhaA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tpt THYMIDINE
PHOSPHORYLASE

(Escherichia
coli) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 VAL A 149
ILE A 145
PHE A 142
GLY A  99
ALA A 103
 None
 1.08A 5mxbA-2tptA:
undetectable		 5mxbA-2tptA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vii PSP OPERON
TRANSCRIPTIONAL
ACTIVATOR

(Escherichia
coli) 		PF00158
(Sigma54_activat) 		5 VAL A 142
LEU A 106
ARG A  95
GLY A  94
PHE A  96
 None
 0.98A 5mxbA-2viiA:
undetectable		 5mxbA-2viiA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xj9 MIPZ

(Caulobacter
vibrioides) 		PF09140
(MipZ) 		5 VAL A   8
ILE A 109
LEU A  41
ARG A 125
GLY A 124
 None
 1.16A 5mxbA-2xj9A:
undetectable		 5mxbA-2xj9A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE

(Streptococcus
pneumoniae) 		PF08305
(NPCBM) 		5 VAL A 321
THR A 322
ILE A 380
ARG A 323
PHE A 409
 None
 1.09A 5mxbA-2yglA:
undetectable		 5mxbA-2yglA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		5 VAL A  55
ILE A  12
LEU A  29
PHE A  19
GLY A  52
 None
 1.21A 5mxbA-2yvlA:
undetectable		 5mxbA-2yvlA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A 324
THR A 323
ILE A 327
TYR A 123
GLY A 263
 None
 1.14A 5mxbA-2z1qA:
undetectable		 5mxbA-2z1qA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE

(Japanese
encephalitis
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		5 VAL A 406
ILE A 384
GLY A 419
ALA A 420
PHE A 418
 None
 1.06A 5mxbA-2z83A:
undetectable		 5mxbA-2z83A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT

(Thermus
thermophilus) 		PF00344
(SecY) 		5 VAL Y  39
ILE Y  44
LEU Y  48
ARG Y 141
GLY Y 136
 None
 1.09A 5mxbA-2zqpY:
undetectable		 5mxbA-2zqpY:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I

(Legionella
pneumophila) 		PF01150
(GDA1_CD39) 		5 THR A  94
ILE A  95
LEU A  99
GLY A  84
PHE A  85
 None
 1.04A 5mxbA-3aarA:
undetectable		 5mxbA-3aarA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ced METHIONINE IMPORT
ATP-BINDING PROTEIN
METN 2

(Staphylococcus
aureus) 		PF09383
(NIL) 		5 VAL A 333
LEU A 311
ARG A 267
GLY A 307
PHE A 270
 None
 1.21A 5mxbA-3cedA:
undetectable		 5mxbA-3cedA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzm HYPOTHETICAL
CONSERVED PROTEIN

(Thermus
thermophilus) 		no annotation 5 VAL A  75
THR A  76
GLY A  18
ALA A  42
PHE A  41
 None
 1.17A 5mxbA-3dzmA:
1.4		 5mxbA-3dzmA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epc PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		5 VAL 2 108
ILE 2 253
LEU 2  86
GLY 2 228
ALA 2 126
 None
 1.00A 5mxbA-3epc2:
undetectable		 5mxbA-3epc2:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epd PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		5 VAL 2 108
ILE 2 252
LEU 2  86
GLY 2 227
ALA 2 126
 None
 0.98A 5mxbA-3epd2:
undetectable		 5mxbA-3epd2:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epf PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		5 VAL 2 108
ILE 2 252
LEU 2  86
GLY 2 227
ALA 2 126
 None
 0.98A 5mxbA-3epf2:
undetectable		 5mxbA-3epf2:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		5 ILE A1160
LEU A1264
PHE A1249
GLY A1137
PHE A1138
 None
 1.06A 5mxbA-3f5fA:
undetectable		 5mxbA-3f5fA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		5 VAL A 200
ILE A 159
LEU A 128
PHE A 148
GLY A 187
 None
 1.01A 5mxbA-3fz0A:
undetectable		 5mxbA-3fz0A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8v FLAGELLIN HOMOLOG

(Sphingomonas
sp. A1) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF07196
(Flagellin_IN) 		5 VAL A 255
THR A 273
ILE A 253
GLY A 266
ALA A 268
 None
 1.13A 5mxbA-3k8vA:
undetectable		 5mxbA-3k8vA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN

(Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 VAL A 288
ILE A 291
LEU A   2
ALA A 284
PHE A  82
 None
 1.20A 5mxbA-3kl4A:
undetectable		 5mxbA-3kl4A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE

(Streptococcus
agalactiae) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 VAL A 406
ILE A 352
ARG A 437
GLY A 438
PHE A 441
 None
 1.18A 5mxbA-3lk7A:
undetectable		 5mxbA-3lk7A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
2) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 ILE A 287
LEU A 295
PHE A 322
GLY A 270
PHE A 271
 None
 1.12A 5mxbA-3m1cA:
0.6		 5mxbA-3m1cA:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1y PHOSPHOSERINE
PHOSPHATASE (SERB)

(Helicobacter
pylori) 		PF00702
(Hydrolase) 		5 ILE A 203
LEU A  81
GLY A 163
ALA A 180
PHE A 181
 None
 1.15A 5mxbA-3m1yA:
undetectable		 5mxbA-3m1yA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9i LENS FIBER MAJOR
INTRINSIC PROTEIN

(Ovis aries) 		PF00230
(MIP) 		5 VAL A 164
THR A 148
ILE A 145
TYR A  89
GLY A  60
 None
 1.13A 5mxbA-3m9iA:
undetectable		 5mxbA-3m9iA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Escherichia
coli) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 VAL A 394
THR A 393
ILE A 397
GLY A 225
ALA A 224
 None
 1.04A 5mxbA-3mogA:
undetectable		 5mxbA-3mogA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0t DIPEPTIDYL PEPTIDASE
2

(Homo sapiens) 		PF05577
(Peptidase_S28) 		5 VAL A 239
ILE A 227
GLY A 234
ALA A 235
PHE A 231
 None
 1.17A 5mxbA-3n0tA:
undetectable		 5mxbA-3n0tA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p42 PREDICTED PROTEIN

(Escherichia
coli) 		PF06251
(Caps_synth_GfcC) 		5 THR A  99
ILE A 100
LEU A  85
GLY A 221
ALA A 183
 None
 0.99A 5mxbA-3p42A:
undetectable		 5mxbA-3p42A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		6 VAL A1041
THR A1044
ILE A1045
LEU A1194
PHE A1048
GLY A1159
 None
 1.03A 5mxbA-3pvlA:
undetectable		 5mxbA-3pvlA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8n 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		5 VAL A 336
THR A 339
ILE A 340
GLY A  79
ALA A  82
 None
 1.17A 5mxbA-3q8nA:
undetectable		 5mxbA-3q8nA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		5 VAL A 288
ILE A 283
TYR A 247
ALA A 268
PHE A 271
 None
 1.19A 5mxbA-3r5tA:
undetectable		 5mxbA-3r5tA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umb DEHALOGENASE-LIKE
HYDROLASE

(Ralstonia
solanacearum) 		PF00702
(Hydrolase) 		5 VAL A 145
ILE A 120
LEU A  15
PHE A   9
GLY A 140
 None
 0.85A 5mxbA-3umbA:
undetectable		 5mxbA-3umbA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsk PENICILLIN-BINDING
PROTEIN 3

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 VAL A  81
ILE A  72
LEU A 318
GLY A 240
PHE A 242
 None
 1.17A 5mxbA-3vskA:
undetectable		 5mxbA-3vskA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wov OLIGOSACCHARYL
TRANSFERASE

(Pyrococcus
abyssi) 		no annotation 5 THR A 605
ILE A 606
LEU A 684
ALA A 550
PHE A 695
 None
 1.17A 5mxbA-3wovA:
undetectable		 5mxbA-3wovA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhl ARGININE KINASE

(Litopenaeus
vannamei) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 VAL A 283
ILE A 285
LEU A 287
PHE A 119
GLY A 345
 None
 0.83A 5mxbA-4bhlA:
0.9		 5mxbA-4bhlA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 VAL A 278
LEU A 333
PHE A 211
GLY A 324
ALA A 289
 None
None
None
SSA  A1001 (-3.3A)
None
 1.15A 5mxbA-4eo4A:
1.1		 5mxbA-4eo4A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdj NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 THR A 362
ILE A 353
LEU A 302
GLY A 320
ALA A 321
 None
 1.19A 5mxbA-4gdjA:
undetectable		 5mxbA-4gdjA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		5 THR A 131
ILE A 132
LEU A  85
GLY A 165
ALA A 161
 None
 1.19A 5mxbA-4ghkA:
undetectable		 5mxbA-4ghkA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkr NECK AND C-TERMINAL
MOTOR DOMAIN OF KAR3

([Candida]
glabrata) 		PF00225
(Kinesin) 		5 VAL A 453
THR A 456
ILE A 457
LEU A 531
PHE A 566
 None
 1.07A 5mxbA-4gkrA:
undetectable		 5mxbA-4gkrA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU

(Yersinia
enterocolitica) 		PF01408
(GFO_IDH_MocA) 		5 ILE A  54
LEU A  34
PHE A  52
GLY A  14
ALA A  39
 None
None
None
SO4  A 401 ( 4.3A)
SO4  A 401 ( 4.0A)
 0.69A 5mxbA-4gmfA:
undetectable		 5mxbA-4gmfA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		5 VAL B 439
THR B 274
ILE B 281
LEU B 233
PHE B 273
 None
 1.08A 5mxbA-4i0wB:
undetectable		 5mxbA-4i0wB:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		5 VAL A  83
ILE A  76
LEU A  55
TYR A 494
PHE A 408
 None
 1.09A 5mxbA-4i8vA:
undetectable		 5mxbA-4i8vA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ied CLASS D
BETA-LACTAMASE

(Fusobacterium
nucleatum) 		PF00905
(Transpeptidase) 		5 VAL A 108
LEU A  90
PHE A  89
GLY A 198
ALA A  56
 KCX  A  60 ( 3.9A)
CL  A 303 ( 4.1A)
None
None
None
 1.19A 5mxbA-4iedA:
1.9		 5mxbA-4iedA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhi MTN13 PROTEIN

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		5 ILE A  39
LEU A  57
TYR A  82
ARG A 140
GLY A 143
 None
None
EMU  A 202 (-4.9A)
None
None
 1.09A 5mxbA-4jhiA:
20.0		 5mxbA-4jhiA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt6 NICOTINE ADENINE
DINUCLEOTIDE
GLYCOHYDROLASE

(Streptococcus
pyogenes) 		PF07461
(NADase_NGA) 		5 VAL A 399
THR A 292
ILE A 293
ARG A 289
PHE A 284
 None
 1.17A 5mxbA-4kt6A:
undetectable		 5mxbA-4kt6A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p17 RABGAP/TBC PROTEIN

(Chlamydomonas
reinhardtii) 		PF00566
(RabGAP-TBC) 		5 VAL A  72
THR A  76
PHE A 250
TYR A  12
GLY A  63
 None
 1.17A 5mxbA-4p17A:
undetectable		 5mxbA-4p17A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		5 VAL 2 108
ILE 2 252
LEU 2  86
GLY 2 227
ALA 2 126
 None
 0.94A 5mxbA-4q4y2:
undetectable		 5mxbA-4q4y2:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE

(Zophobas
atratus) 		PF00501
(AMP-binding) 		5 VAL A 206
LEU A  24
PHE A 238
ARG A 244
GLY A 230
 None
 1.17A 5mxbA-4w8oA:
undetectable		 5mxbA-4w8oA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpq MCG133388, ISOFORM
CRA_F

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 ILE A  61
LEU A  66
ARG A  44
GLY A  43
PHE A  46
 None
 1.04A 5mxbA-4zpqA:
undetectable		 5mxbA-4zpqA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00478
(IMPDH) 		5 ILE A 432
LEU A 436
GLY A 360
ALA A 364
PHE A 363
 None
None
IMP  A 501 (-3.7A)
None
None
 1.04A 5mxbA-5ahmA:
undetectable		 5mxbA-5ahmA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 5 VAL A1561
ILE A1600
LEU A1594
GLY A1543
ALA A1545
 None
 0.96A 5mxbA-5b2oA:
undetectable		 5mxbA-5b2oA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cy1 TRANSPOSON TN3
RESOLVASE

(Escherichia
coli) 		PF00239
(Resolvase)
PF02796
(HTH_7) 		5 VAL A  90
ILE A  61
LEU A  51
PHE A   4
GLY A  87
 None
 1.12A 5mxbA-5cy1A:
undetectable		 5mxbA-5cy1A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exp TRANSCRIPTIONAL
REGULATOR FLEQ

(Pseudomonas
aeruginosa) 		PF00158
(Sigma54_activat) 		5 VAL A 280
LEU A 244
ARG A 233
GLY A 232
PHE A 234
 None
 1.07A 5mxbA-5expA:
undetectable		 5mxbA-5expA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giu PROLINE DIPEPTIDASE

(Deinococcus
radiodurans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 VAL A 145
ILE A 166
LEU A 181
GLY A 175
ALA A 173
 None
 0.96A 5mxbA-5giuA:
undetectable		 5mxbA-5giuA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkv ESTERASE A

(Caulobacter
vibrioides) 		PF00144
(Beta-lactamase) 		5 VAL A  42
ILE A  37
GLY A 346
ALA A  34
PHE A  35
 None
 1.17A 5mxbA-5gkvA:
undetectable		 5mxbA-5gkvA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0i ASPARAGINYL
ENDOPEPTIDASE

(Oldenlandia
affinis) 		PF01650
(Peptidase_C13) 		5 VAL A  60
ILE A 170
LEU A 210
GLY A 147
ALA A 144
 None
 1.17A 5mxbA-5h0iA:
undetectable		 5mxbA-5h0iA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I

(Geobacillus
stearothermophilus) 		PF01654
(Cyt_bd_oxida_I) 		5 VAL A 324
THR A 327
ILE A 328
LEU A 365
PHE A 331
 None
 0.97A 5mxbA-5ir6A:
undetectable		 5mxbA-5ir6A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrj BETA-XYLANASE

(Acremonium
chrysogenum) 		no annotation 5 VAL A 219
ILE A 222
LEU A 229
GLY A 244
ALA A 246
 None
 1.02A 5mxbA-5mrjA:
undetectable		 5mxbA-5mrjA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mru TETRACYCLINE
REPRESSOR, CLASS A

(Pseudomonas sp.) 		no annotation 5 THR A 136
ILE A 137
LEU A 191
PHE A 140
GLY A 197
 None
TDC  A 301 ( 4.5A)
None
None
None
 1.11A 5mxbA-5mruA:
undetectable		 5mxbA-5mruA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6f LPXTG-MOTIF CELL
WALL ANCHOR DOMAIN
PROTEIN

(Mobiluncus
mulieris) 		no annotation 5 VAL A  11
ILE A  29
LEU A  50
ALA A  16
PHE A  17
 None
 1.06A 5mxbA-5u6fA:
undetectable		 5mxbA-5u6fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y50 PROTEIN
DETOXIFICATION 14

(Arabidopsis
thaliana) 		no annotation 5 ILE A  68
LEU A 133
PHE A  72
GLY A 277
ALA A 286
 None
 1.20A 5mxbA-5y50A:
undetectable		 5mxbA-5y50A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwf NITRIC-OXIDE
REDUCTASE

(Neisseria
meningitidis) 		no annotation 6 THR A 349
LEU A 354
PHE A 353
GLY A 648
ALA A 646
PHE A 649
 None
 1.11A 5mxbA-6fwfA:
undetectable		 5mxbA-6fwfA:
16.05