SIMILAR PATTERNS OF AMINO ACIDS FOR 5MWY_A_YNUA1101_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aux SYNAPSIN IA

(Bos taurus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		4 ARG A 328
CYH A 360
THR A 359
PHE A 244
 None
 1.30A 5mwyA-1auxA:
undetectable		 5mwyA-1auxA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq6 XYS1

(Streptomyces
halstedii) 		PF00331
(Glyco_hydro_10) 		4 ARG A 159
PHE A 155
THR A 174
PHE A 224
 None
 1.30A 5mwyA-1nq6A:
undetectable		 5mwyA-1nq6A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi) 		PF05544
(Pro_racemase) 		4 GLN A 241
CYH A 300
THR A 302
PHE A 220
 None
PYC  A 700 (-3.4A)
PYC  A 700 (-2.6A)
None
 1.22A 5mwyA-1w61A:
undetectable		 5mwyA-1w61A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w74 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A

(Mycobacterium
tuberculosis) 		PF00160
(Pro_isomerase) 		4 GLN A  81
ARG A  73
THR A  54
PHE A  65
 None
 1.38A 5mwyA-1w74A:
undetectable		 5mwyA-1w74A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wer P120GAP

(Homo sapiens) 		PF00616
(RasGAP) 		4 ARG A 776
CYH A1002
THR A1030
PHE A 726
 None
 1.42A 5mwyA-1werA:
undetectable		 5mwyA-1werA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Streptococcus
pneumoniae) 		PF03070
(TENA_THI-4) 		4 GLN A  84
ARG A  80
PHE A  81
PHE A  57
 None
None
None
ACY  A 801 (-3.4A)
 1.32A 5mwyA-1z72A:
undetectable		 5mwyA-1z72A:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 GLN A 711
ARG A 752
PHE A 764
PHE A 891
 BHM  A   1 (-2.2A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
None
 0.54A 5mwyA-2ax9A:
36.4		 5mwyA-2ax9A:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bii NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 GLN A 224
PHE A  87
CYH A 385
PHE A  79
 None
MTV  A1479 (-3.5A)
None
None
 1.24A 5mwyA-2biiA:
undetectable		 5mwyA-2biiA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like) 		4 PHE A 147
CYH A 170
THR A 205
PHE A 134
 None
 1.47A 5mwyA-2cw6A:
undetectable		 5mwyA-2cw6A:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		6 GLN A  39
ARG A  80
PHE A  92
CYH A 205
THR A 208
PHE A 219
 1CA  A 247 (-3.1A)
1CA  A 247 (-3.8A)
None
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.31A 5mwyA-2q3yA:
39.0		 5mwyA-2q3yA:
72.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		4 PHE A  98
CYH A 205
THR A 208
PHE A 219
 None
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 1.21A 5mwyA-2q3yA:
39.0		 5mwyA-2q3yA:
72.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2u XYLOSIDASE/ARABINOSI
DASE

(Selenomonas
ruminantium) 		PF04616
(Glyco_hydro_43)
PF07081
(DUF1349) 		4 GLN A 346
ARG A 386
THR A 106
PHE A  60
 None
 1.29A 5mwyA-3c2uA:
undetectable		 5mwyA-3c2uA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF13847
(Methyltransf_31) 		4 PHE A 101
CYH A  45
THR A  51
PHE A  93
 None
 1.12A 5mwyA-3g5tA:
undetectable		 5mwyA-3g5tA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		4 GLN A 463
PHE A 433
THR A 499
PHE A 487
 None
 1.22A 5mwyA-3ibjA:
undetectable		 5mwyA-3ibjA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		4 GLN A1667
PHE A1674
CYH A1748
THR A1745
 GOL  A 366 (-4.2A)
None
None
None
 1.20A 5mwyA-3ig3A:
undetectable		 5mwyA-3ig3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		4 ARG A 117
PHE A 119
CYH A 134
PHE A  41
 None
 1.45A 5mwyA-3j4sA:
undetectable		 5mwyA-3j4sA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN

(Escherichia
coli) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30) 		4 GLN D 328
PHE D 321
THR D 180
PHE D 145
 None
 1.38A 5mwyA-3k70D:
undetectable		 5mwyA-3k70D:
18.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLN A 725
ARG A 766
PHE A 778
CYH A 891
THR A 894
PHE A 905
 WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
None
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.74A 5mwyA-3kbaA:
36.1		 5mwyA-3kbaA:
51.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		4 GLN A  34
PHE A 253
THR A 115
PHE A 324
 None
LEU  A 601 (-4.2A)
None
None
 1.38A 5mwyA-3mpnA:
undetectable		 5mwyA-3mpnA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE

(Escherichia
coli) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		4 GLN A 201
PHE A  89
THR A 585
PHE A 319
 None
 1.42A 5mwyA-3o98A:
undetectable		 5mwyA-3o98A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pss QNR

(Aeromonas
hydrophila) 		PF00805
(Pentapeptide)
PF13599
(Pentapeptide_4) 		4 ARG A  11
PHE A  32
CYH A  83
PHE A  98
 None
 1.49A 5mwyA-3pssA:
undetectable		 5mwyA-3pssA:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		6 GLN A  39
ARG A  80
PHE A  92
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.29A 5mwyA-3ry9A:
38.1		 5mwyA-3ry9A:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		4 PHE A  98
CYH A 205
THR A 208
PHE A 219
 None
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.33A 5mwyA-3ry9A:
38.1		 5mwyA-3ry9A:
59.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		4 GLN A 778
ARG A 792
CYH A 598
PHE A 846
 None
 1.45A 5mwyA-3s1sA:
undetectable		 5mwyA-3s1sA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 GLN A 588
PHE A 777
THR A 517
PHE A 707
 None
 1.43A 5mwyA-4bedA:
undetectable		 5mwyA-4bedA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 GLN A 296
PHE A 269
CYH A 137
PHE A 186
 None
 1.45A 5mwyA-4eo4A:
undetectable		 5mwyA-4eo4A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Tetrahymena
thermophila) 		PF05028
(PARG_cat) 		4 PHE A 352
CYH A 396
THR A 222
PHE A 230
 None
APR  A 501 (-4.2A)
None
None
 1.42A 5mwyA-4eppA:
undetectable		 5mwyA-4eppA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE

(Prochloron
didemni) 		PF00082
(Peptidase_S8) 		4 PHE A 567
CYH A 620
THR A 623
PHE A 558
 None
 1.43A 5mwyA-4h6xA:
undetectable		 5mwyA-4h6xA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 GLN A 599
PHE A 572
CYH A 450
PHE A 499
 None
 1.43A 5mwyA-4hwtA:
undetectable		 5mwyA-4hwtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7m PROTEIN DOM3Z

(Mus musculus) 		PF08652
(RAI1) 		4 GLN A 339
ARG A 155
THR A 141
PHE A 330
 None
 1.41A 5mwyA-4j7mA:
undetectable		 5mwyA-4j7mA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf8 TRWG COMPONENT OF
TYPE IV SECRETION
SYSTEM

(Bartonella
birtlesii) 		PF04335
(VirB8) 		4 GLN A 104
PHE A 217
THR A 224
PHE A 175
 None
 1.48A 5mwyA-4jf8A:
undetectable		 5mwyA-4jf8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
ACETALDEHYDE
DEHYDROGENASE

(Thermomonospora
curvata;
Thermomonospora
curvata) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm)
PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		4 GLN A 329
CYH B 146
THR B 145
PHE B 189
 None
NAD  B 401 (-3.7A)
None
None
 1.49A 5mwyA-4lrsA:
undetectable		 5mwyA-4lrsA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mj3 HALOALKANE
DEHALOGENASE

(Mycolicibacterium
rhodesiae) 		PF00561
(Abhydrolase_1) 		4 GLN A 270
PHE A 238
THR A 148
PHE A 246
 None
 1.45A 5mwyA-4mj3A:
undetectable		 5mwyA-4mj3A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01425
(Amidase)
PF02934
(GatB_N) 		4 GLN A 184
ARG B 105
CYH A  64
THR A  62
 None
 1.37A 5mwyA-4n0iA:
undetectable		 5mwyA-4n0iA:
20.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLN A 570
ARG A 611
PHE A 623
CYH A 736
THR A 739
PHE A 749
 MOF  A 801 (-2.9A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
 0.36A 5mwyA-4p6wA:
35.3		 5mwyA-4p6wA:
52.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLN A 776
ARG A 817
PHE A 829
CYH A 942
THR A 945
PHE A 956
 CV7  A1987 (-3.0A)
CV7  A1987 (-3.7A)
CV7  A1987 (-4.9A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 0.26A 5mwyA-4udbA:
37.6		 5mwyA-4udbA:
99.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 ARG B  78
CYH A  81
THR A  87
PHE A  97
 None
 1.41A 5mwyA-4wj3B:
undetectable		 5mwyA-4wj3B:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj5 CYCLIC AMP-GMP
SYNTHASE

(Vibrio cholerae) 		no annotation 4 PHE A 337
CYH A 283
THR A 119
PHE A 268
 None
 1.42A 5mwyA-4xj5A:
3.1		 5mwyA-4xj5A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 4 PHE A 333
CYH A 279
THR A 117
PHE A 264
 None
 1.42A 5mwyA-4xj6A:
3.4		 5mwyA-4xj6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp3 MYCOCEROSIC ACID
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF14765
(PS-DH) 		4 GLN A1104
PHE A1059
CYH A 948
PHE A 970
 None
None
None
EDO  A1202 ( 4.5A)
 1.32A 5mwyA-5bp3A:
undetectable		 5mwyA-5bp3A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza C
virus) 		PF00603
(Flu_PA) 		4 GLN A 319
CYH A 551
THR A 523
PHE A 525
 None
 1.25A 5mwyA-5d9aA:
undetectable		 5mwyA-5d9aA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B

(Neotoma lepida) 		PF00067
(p450) 		4 GLN A 172
PHE A 206
CYH A 180
PHE A 188
 None
 1.43A 5mwyA-5e0eA:
2.4		 5mwyA-5e0eA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee4 HPUA

(Kingella
denitrificans) 		PF16960
(HpuA) 		4 GLN A  39
ARG A  37
CYH A 120
THR A  88
 None
 1.34A 5mwyA-5ee4A:
undetectable		 5mwyA-5ee4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giv CARBOXYPEPTIDASE 1

(Deinococcus
radiodurans) 		PF02074
(Peptidase_M32) 		4 GLN A 275
PHE A 225
THR A 233
PHE A 237
 None
 1.44A 5mwyA-5givA:
undetectable		 5mwyA-5givA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j97 CAPRIN-2

(Homo sapiens) 		no annotation 4 PHE A 314
CYH A 262
THR A 261
PHE A 282
 None
 1.43A 5mwyA-5j97A:
undetectable		 5mwyA-5j97A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 ARG A 202
PHE A 203
THR A 260
PHE A 136
 None
 1.40A 5mwyA-5jm7A:
undetectable		 5mwyA-5jm7A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		4 GLN A 525
PHE A 617
THR A 460
PHE A 535
 None
 1.43A 5mwyA-5jrlA:
undetectable		 5mwyA-5jrlA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 6 GLN A 776
ARG A 817
PHE A 829
CYH A 942
THR A 945
PHE A 956
 ECV  A1101 (-2.9A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.9A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 0.27A 5mwyA-5mwpA:
43.2		 5mwyA-5mwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 4 PHE A 835
CYH A 942
THR A 945
PHE A 956
 None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 1.14A 5mwyA-5mwpA:
43.2		 5mwyA-5mwpA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 GLN A  39
ARG A  80
PHE A  92
CYH A 205
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 (-3.5A)
1TA  A 301 (-4.4A)
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 0.32A 5mwyA-5ufsA:
36.9		 5mwyA-5ufsA:
53.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zh5 LYSINE--TRNA LIGASE

(Plasmodium
falciparum) 		no annotation 4 GLN A 367
ARG A 268
PHE A 364
PHE A 373
 None
 1.31A 5mwyA-5zh5A:
undetectable		 5mwyA-5zh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhc PSEUDOPODIUM-ENRICHE
D ATYPICAL KINASE 1

(Homo sapiens) 		no annotation 4 GLN A1664
PHE A1730
CYH A1305
PHE A1706
 None
 1.38A 5mwyA-6bhcA:
undetectable		 5mwyA-6bhcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 4 ARG A 453
PHE A 456
CYH A 467
PHE A 622
 None
 1.48A 5mwyA-6c0tA:
undetectable		 5mwyA-6c0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs NPL4

(Chaetomium
thermophilum) 		no annotation 4 GLN A 341
PHE A 401
THR A 347
PHE A 271
 None
 1.40A 5mwyA-6chsA:
undetectable		 5mwyA-6chsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0x MAD2L1-BINDING
PROTEIN

(Homo sapiens) 		no annotation 4 GLN P 179
PHE P  60
CYH P  74
PHE P 142
 None
 1.08A 5mwyA-6f0xP:
undetectable		 5mwyA-6f0xP:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhf -

(-) 		no annotation 4 ARG A 191
PHE A 187
THR A 207
PHE A 256
 None
 1.45A 5mwyA-6fhfA:
undetectable		 5mwyA-6fhfA:
undetectable