SIMILAR PATTERNS OF AMINO ACIDS FOR 5MWY_A_YNUA1101_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ch4 | MODULE-SUBSTITUTEDCHIMERA HEMOGLOBINBETA-ALPHA (Homo sapiens) |
PF00042(Globin) | 5 | LEU A 81ALA A 135SER A 129LEU A 130LEU A 3 | None | 1.09A | 5mwyA-1ch4A:undetectable | 5mwyA-1ch4A:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cjy | PROTEIN (CYTOSOLICPHOSPHOLIPASE A2) (Homo sapiens) |
PF00168(C2)PF01735(PLA2_B) | 5 | LEU A 341ALA A 486SER A 398LEU A 400MET A 417 | None | 1.18A | 5mwyA-1cjyA:undetectable | 5mwyA-1cjyA:15.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1csj | HEPATITIS C VIRUSRNA POLYMERASE(NS5B) (Hepacivirus C) |
PF00998(RdRP_3) | 5 | LEU A 285LEU A 175ALA A 252TRP A 123LEU A 245 | None | 1.11A | 5mwyA-1csjA:undetectable | 5mwyA-1csjA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dab | P.69 PERTACTIN (Bordetellapertussis) |
PF03212(Pertactin) | 5 | LEU A 329LEU A 353ALA A 384SER A 400LEU A 399 | None | 1.16A | 5mwyA-1dabA:undetectable | 5mwyA-1dabA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fns | VON WILLEBRANDFACTOR (Homo sapiens) |
PF00092(VWA) | 5 | LEU A 519LEU A 621ALA A 623SER A 679LEU A 677 | None | 0.98A | 5mwyA-1fnsA:undetectable | 5mwyA-1fnsA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hxj | BETA-GLUCOSIDASE (Zea mays) |
PF00232(Glyco_hydro_1) | 5 | LEU A 182LEU A 253LEU A 285MET A 388LEU A 325 | None | 1.10A | 5mwyA-1hxjA:undetectable | 5mwyA-1hxjA:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jl5 | OUTER PROTEIN YOPM (Yersinia pestis) |
PF12468(TTSSLRR) | 5 | LEU A1081LEU A1078ASN A1101SER A1095LEU A1093 | None | 1.15A | 5mwyA-1jl5A:undetectable | 5mwyA-1jl5A:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lbk | GLUTATHIONES-TRANSFERASE CLASSPI CHIMAERA (CODA) (Homo sapiens) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | LEU A 158LEU A 155ASN A 154ALA A 151LEU A 132 | None | 1.16A | 5mwyA-1lbkA:undetectable | 5mwyA-1lbkA:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mi1 | NEUROBEACHIN (Homo sapiens) |
PF02138(Beach)PF14844(PH_BEACH) | 5 | LEU A2290LEU A2293ASN A2294ALA A2297LEU A2546 | None | 0.53A | 5mwyA-1mi1A:undetectable | 5mwyA-1mi1A:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 346ALA A 350TRP A 383LEU A 391MET A 421 | EST A 1 (-4.4A)EST A 1 ( 3.7A)NoneEST A 1 ( 3.9A)EST A 1 ( 4.3A) | 0.67A | 5mwyA-1pcgA:26.9 | 5mwyA-1pcgA:25.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1spg | HEMOGLOBIN (Leiostomusxanthurus) |
PF00042(Globin) | 5 | LEU A 131LEU A 134ALA A 137SER A 86LEU A 85 | NoneNoneNoneNoneHEM A 144 ( 4.9A) | 1.20A | 5mwyA-1spgA:undetectable | 5mwyA-1spgA:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t77 | LIPOPOLYSACCHARIDE-RESPONSIVE ANDBEIGE-LIKE ANCHORPROTEIN (Homo sapiens) |
PF02138(Beach)PF14844(PH_BEACH) | 5 | LEU A2226LEU A2229ASN A2230ALA A2233LEU A2482 | None | 0.52A | 5mwyA-1t77A:undetectable | 5mwyA-1t77A:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t8w | AMP NUCLEOSIDASE (Escherichiacoli) |
PF01048(PNP_UDP_1)PF10423(AMNp_N) | 5 | LEU A 202LEU A 275ALA A 262SER A 232LEU A 231 | None | 1.21A | 5mwyA-1t8wA:undetectable | 5mwyA-1t8wA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkh | PUTATIVE SERINEHYDROLASE (Saccharomycescerevisiae) |
PF07859(Abhydrolase_3) | 5 | LEU A 138LEU A 141SER A 200SER A 197LEU A 196 | None | 1.21A | 5mwyA-1vkhA:undetectable | 5mwyA-1vkhA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x55 | ASPARAGINYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 5 | LEU A 404SER A 205LEU A 206MET A 250LEU A 149 | None | 1.23A | 5mwyA-1x55A:undetectable | 5mwyA-1x55A:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x9d | ENDOPLASMICRETICULUMMANNOSYL-OLIGOSACCHARIDE1,2-ALPHA-MANNOSIDASE (Homo sapiens) |
PF01532(Glyco_hydro_47) | 5 | LEU A 336LEU A 339ALA A 342SER A 349LEU A 350 | None | 1.11A | 5mwyA-1x9dA:undetectable | 5mwyA-1x9dA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xb7 | STEROID HORMONERECEPTOR ERR1 (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 327LEU A 324ALA A 396LEU A 401LEU A 380 | None | 1.16A | 5mwyA-1xb7A:26.5 | 5mwyA-1xb7A:28.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yg2 | GENE ACTIVATOR APHA (Vibrio cholerae) |
PF03551(PadR)PF10400(Vir_act_alpha_C) | 5 | LEU A 172LEU A 175ASN A 176ALA A 179SER A 107 | None | 0.95A | 5mwyA-1yg2A:undetectable | 5mwyA-1yg2A:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yjg | SURFACE PROTEIN VSPA (Borreliaturicatae) |
PF01441(Lipoprotein_6) | 5 | LEU A 176LEU A 179ASN A 180LEU A 109LEU A 64 | None | 1.22A | 5mwyA-1yjgA:undetectable | 5mwyA-1yjgA:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ytl | ACETYL-COADECARBOXYLASE/SYNTHASE COMPLEX EPSILONSUBUNIT 2 (Archaeoglobusfulgidus) |
PF02552(CO_dh) | 5 | LEU A 40LEU A 113ALA A 138SER A 152LEU A 22 | None | 1.23A | 5mwyA-1ytlA:undetectable | 5mwyA-1ytlA:17.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ax9 | ANDROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 8 | LEU A 701LEU A 704ASN A 705TRP A 741MET A 742MET A 780MET A 787LEU A 873 | NoneBHM A 1 (-4.0A)BHM A 1 (-3.6A)NoneBHM A 1 ( 4.0A)BHM A 1 ( 4.3A)BHM A 1 (-3.6A)BHM A 1 (-4.4A) | 1.23A | 5mwyA-2ax9A:36.4 | 5mwyA-2ax9A:44.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gsr | CLASS PI GSTGLUTATHIONES-TRANSFERASE (Sus scrofa) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | LEU A 156LEU A 153ASN A 152ALA A 149LEU A 130 | None | 1.14A | 5mwyA-2gsrA:undetectable | 5mwyA-2gsrA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ijr | HYPOTHETICAL PROTEINAPI92 (Yersiniapseudotuberculosis) |
PF06924(DUF1281) | 5 | LEU A 222LEU A 224MET A 21MET A 169LEU A 241 | None | 1.17A | 5mwyA-2ijrA:undetectable | 5mwyA-2ijrA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ip2 | PROBABLEPHENAZINE-SPECIFICMETHYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 5 | LEU A 88LEU A 87SER A 153LEU A 155MET A 324 | None | 1.19A | 5mwyA-2ip2A:undetectable | 5mwyA-2ip2A:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nc8 | LIPOPROTEIN LPPM (Mycobacteriumtuberculosis) |
no annotation | 5 | LEU A 60ALA A 71SER A 88SER A 41LEU A 90 | None | 1.20A | 5mwyA-2nc8A:undetectable | 5mwyA-2nc8A:23.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2q3y | ANCESTRAL CORTICIODRECEPTOR (unidentified) |
PF00104(Hormone_recep) | 6 | ALA A 36TRP A 69MET A 70LEU A 77MET A 115LEU A 201 | 1CA A 247 (-3.6A)None1CA A 247 ( 3.8A)1CA A 247 ( 3.9A)1CA A 247 ( 3.7A)1CA A 247 ( 4.2A) | 0.80A | 5mwyA-2q3yA:39.0 | 5mwyA-2q3yA:72.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2q3y | ANCESTRAL CORTICIODRECEPTOR (unidentified) |
PF00104(Hormone_recep) | 9 | LEU A 29LEU A 32ASN A 33ALA A 36TRP A 69MET A 70LEU A 77MET A 108LEU A 201 | 1CA A 247 ( 3.6A)1CA A 247 (-4.0A)1CA A 247 (-2.9A)1CA A 247 (-3.6A)None1CA A 247 ( 3.8A)1CA A 247 ( 3.9A)1CA A 247 (-3.9A)1CA A 247 ( 4.2A) | 0.33A | 5mwyA-2q3yA:39.0 | 5mwyA-2q3yA:72.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qga | ADENYLOSUCCINATELYASE (Plasmodiumvivax) |
PF00206(Lyase_1)PF08328(ASL_C) | 5 | LEU B 259ASN B 263SER B 357LEU B 359LEU B 352 | None | 1.17A | 5mwyA-2qgaB:undetectable | 5mwyA-2qgaB:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r1h | HEMOGLOBIN SUBUNITALPHA-4 (Oncorhynchusmykiss) |
PF00042(Globin) | 5 | LEU A 130LEU A 133ALA A 136SER A 85LEU A 84 | NoneNoneNoneNoneHEM A 143 (-4.7A) | 1.16A | 5mwyA-2r1hA:undetectable | 5mwyA-2r1hA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x5f | ASPARTATE_TYROSINE_PHENYLALANINEPYRIDOXAL-5'PHOSPHATE-DEPENDENTAMINOTRANSFERASE (Staphylococcusaureus) |
PF00155(Aminotran_1_2) | 5 | LEU A 8LEU A 12ASN A 9LEU A 260LEU A 130 | None | 1.21A | 5mwyA-2x5fA:undetectable | 5mwyA-2x5fA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xym | RNA-DIRECTED RNAPOLYMERASE (Hepacivirus C) |
PF00998(RdRP_3) | 5 | LEU A 285LEU A 175ALA A 252TRP A 123LEU A 245 | None | 1.21A | 5mwyA-2xymA:undetectable | 5mwyA-2xymA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z81 | TOLL-LIKE RECEPTOR2, VARIABLELYMPHOCYTE RECEPTORB (Eptatretusburgeri;Mus musculus) |
PF11921(DUF3439)PF13306(LRR_5)PF13516(LRR_6)PF13855(LRR_8) | 5 | LEU A 269LEU A 272MET A 251LEU A 221LEU A 227 | None | 1.05A | 5mwyA-2z81A:undetectable | 5mwyA-2z81A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z81 | TOLL-LIKE RECEPTOR2, VARIABLELYMPHOCYTE RECEPTORB (Eptatretusburgeri;Mus musculus) |
PF11921(DUF3439)PF13306(LRR_5)PF13516(LRR_6)PF13855(LRR_8) | 5 | LEU A 269LEU A 272MET A 251SER A 249LEU A 227 | None | 1.04A | 5mwyA-2z81A:undetectable | 5mwyA-2z81A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z84 | UFM1-SPECIFICPROTEASE 1 (Mus musculus) |
PF07910(Peptidase_C78) | 5 | LEU A 75LEU A 78ALA A 81SER A 105LEU A 108 | None | 1.17A | 5mwyA-2z84A:undetectable | 5mwyA-2z84A:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zy2 | L-ASPARTATE4-CARBOXYLYASE (Pseudomonas sp.ATCC 19121) |
PF00155(Aminotran_1_2) | 5 | LEU A 281ALA A 272SER A 266LEU A 267LEU A 238 | None | 1.21A | 5mwyA-2zy2A:undetectable | 5mwyA-2zy2A:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a74 | LYSYL-TRNASYNTHETASE (Geobacillusstearothermophilus) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 6 | LEU A 283LEU A 287ASN A 286ALA A 289LEU A 471LEU A 405 | None | 1.35A | 5mwyA-3a74A:undetectable | 5mwyA-3a74A:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cwc | PUTATIVE GLYCERATEKINASE 2 (Salmonellaenterica) |
PF02595(Gly_kinase) | 5 | LEU A 171LEU A 153SER A 177LEU A 179LEU A 237 | None | 1.19A | 5mwyA-3cwcA:undetectable | 5mwyA-3cwcA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e9p | PRE-MRNA-SPLICINGFACTOR 8 (Saccharomycescerevisiae) |
PF12134(PRP8_domainIV) | 5 | LEU A2015LEU A2012TRP A1995LEU A1889LEU A2039 | None | 1.09A | 5mwyA-3e9pA:undetectable | 5mwyA-3e9pA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eco | MEPR (Staphylococcusaureus) |
PF12802(MarR_2) | 5 | LEU A 68LEU A 71SER A 96LEU A 100LEU A 93 | None | 0.98A | 5mwyA-3ecoA:undetectable | 5mwyA-3ecoA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3enu | PUTATIVEUNCHARACTERIZEDPROTEIN (Nitrosospiramultiformis) |
PF08964(Crystall_3) | 5 | LEU A 137LEU A 98ALA A 117SER A 89LEU A 122 | None | 1.13A | 5mwyA-3enuA:undetectable | 5mwyA-3enuA:17.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kba | PROGESTERONERECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 7 | LEU A 715LEU A 718ASN A 719TRP A 755MET A 756LEU A 763LEU A 887 | WOW A 1 (-3.9A)WOW A 1 (-4.2A)WOW A 1 (-3.3A)NoneWOW A 1 ( 4.1A)WOW A 1 ( 4.0A)WOW A 1 (-4.0A) | 0.94A | 5mwyA-3kbaA:36.1 | 5mwyA-3kbaA:51.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ls1 | SLL1638 PROTEIN (Synechocystissp. PCC 6803) |
PF05757(PsbQ) | 5 | LEU A 79ALA A 105SER A 140LEU A 142MET A 55 | None | 1.21A | 5mwyA-3ls1A:undetectable | 5mwyA-3ls1A:16.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lxm | ASPARTATECARBAMOYLTRANSFERASE (Yersinia pestis) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | LEU A 216SER A 253SER A 252LEU A 255MET A 228 | None | 1.04A | 5mwyA-3lxmA:undetectable | 5mwyA-3lxmA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n90 | THYLAKOID LUMENAL 15KDA PROTEIN 1,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00805(Pentapeptide) | 5 | LEU A 194LEU A 202ALA A 206MET A 173LEU A 168 | None | 1.14A | 5mwyA-3n90A:undetectable | 5mwyA-3n90A:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o76 | GLUTATHIONES-TRANSFERASE P 1 (Mus musculus) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | LEU A 158LEU A 155ASN A 154ALA A 151LEU A 132 | None | 1.16A | 5mwyA-3o76A:undetectable | 5mwyA-3o76A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pvt | PHENYLACETIC ACIDDEGRADATION PROTEINPAAA (Escherichiacoli) |
PF05138(PaaA_PaaC) | 5 | LEU A 86LEU A 31LEU A 136MET A 148LEU A 79 | None | 1.20A | 5mwyA-3pvtA:2.0 | 5mwyA-3pvtA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qgh | RNA-DIRECTED RNAPOLYMERASE (Hepacivirus C) |
PF00998(RdRP_3) | 5 | LEU A 285LEU A 175ALA A 252TRP A 123LEU A 245 | None | 1.11A | 5mwyA-3qghA:undetectable | 5mwyA-3qghA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rbl | AROMATIC L-AMINOACID DECARBOXYLASE (Homo sapiens) |
PF00282(Pyridoxal_deC) | 5 | LEU A 222ALA A 216SER A 250LEU A 243MET A 239 | None | 1.23A | 5mwyA-3rblA:undetectable | 5mwyA-3rblA:20.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ry9 | ANCESTRALGLUCOCORTICOIDRECEPTOR 1 (syntheticconstruct) |
PF00104(Hormone_recep) | 8 | LEU A 29LEU A 32ASN A 33TRP A 69MET A 70LEU A 77MET A 108LEU A 201 | 1CA A 249 ( 3.8A)1CA A 249 (-3.9A)1CA A 249 (-3.0A)None1CA A 249 ( 3.8A)1CA A 249 ( 4.1A)1CA A 249 (-3.6A)1CA A 249 ( 4.2A) | 0.34A | 5mwyA-3ry9A:38.3 | 5mwyA-3ry9A:59.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ry9 | ANCESTRALGLUCOCORTICOIDRECEPTOR 1 (syntheticconstruct) |
PF00104(Hormone_recep) | 5 | TRP A 69MET A 70LEU A 77MET A 115LEU A 201 | None1CA A 249 ( 3.8A)1CA A 249 ( 4.1A)1CA A 249 (-3.6A)1CA A 249 ( 4.2A) | 0.86A | 5mwyA-3ry9A:38.3 | 5mwyA-3ry9A:59.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sbg | PRE-MRNA-SPLICINGFACTOR 8 (Saccharomycescerevisiae) |
PF08084(PROCT)PF12134(PRP8_domainIV) | 5 | LEU A2015LEU A2012TRP A1995LEU A1889LEU A2039 | None | 1.00A | 5mwyA-3sbgA:undetectable | 5mwyA-3sbgA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wh7 | BETA-GLUCOSIDASE (metagenomes) |
PF00232(Glyco_hydro_1) | 5 | LEU A 224LEU A 222ASN A 223SER A 194LEU A 198 | None | 1.19A | 5mwyA-3wh7A:undetectable | 5mwyA-3wh7A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wrc | GALLATE DIOXYGENASE (Sphingomonaspaucimobilis) |
PF02900(LigB)PF07746(LigA) | 5 | LEU A 122SER A 128SER A 131LEU A 130LEU A 90 | None | 1.18A | 5mwyA-3wrcA:undetectable | 5mwyA-3wrcA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x1l | CRISPR SYSTEM CMRSUBUNIT CMR2 (Pyrococcusfuriosus) |
PF12469(DUF3692) | 5 | LEU A 676ALA A 688SER A 711LEU A 710LEU A 734 | None | 1.19A | 5mwyA-3x1lA:undetectable | 5mwyA-3x1lA:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b16 | CHITINASE LIKELECTIN (Tamarindusindica) |
PF00704(Glyco_hydro_18) | 5 | LEU A 136LEU A 141ALA A 172SER A 157LEU A 156 | None | 1.17A | 5mwyA-4b16A:undetectable | 5mwyA-4b16A:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ev0 | TRANSCRIPTIONREGULATOR, CRPFAMILY (Thermusthermophilus) |
PF00027(cNMP_binding)PF13545(HTH_Crp_2) | 5 | LEU A 73LEU A 45SER A 20LEU A 19LEU A 108 | None | 1.17A | 5mwyA-4ev0A:undetectable | 5mwyA-4ev0A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fcg | UNCHARACTERIZEDPROTEIN (Xanthomonaseuvesicatoria) |
PF13855(LRR_8) | 5 | LEU A 343LEU A 320ALA A 322LEU A 292LEU A 350 | NoneNone CL A 503 (-4.4A)NoneNone | 1.21A | 5mwyA-4fcgA:undetectable | 5mwyA-4fcgA:24.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g2c | DYP2 (Amycolatopsissp. ATCC 39116) |
no annotation | 5 | LEU A 466LEU A 57ASN A 58MET A 64LEU A 141 | NoneNoneACT A 514 (-3.4A)NoneNone | 1.19A | 5mwyA-4g2cA:undetectable | 5mwyA-4g2cA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ifq | NUCLEOPORIN NUP192 (Saccharomycescerevisiae) |
PF11894(Nup192) | 5 | LEU A 37LEU A 35ASN A 36LEU A 200LEU A 145 | None | 1.15A | 5mwyA-4ifqA:undetectable | 5mwyA-4ifqA:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kng | LEUCINE-RICHREPEAT-CONTAININGG-PROTEIN COUPLEDRECEPTOR 5 (Homo sapiens) |
PF00560(LRR_1)PF01462(LRRNT)PF13855(LRR_8) | 5 | LEU A 143LEU A 167ALA A 190SER A 211LEU A 209 | None | 1.23A | 5mwyA-4kngA:undetectable | 5mwyA-4kngA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mna | LRR RECEPTOR-LIKESERINE/THREONINE-PROTEIN KINASE FLS2 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13516(LRR_6)PF13855(LRR_8) | 5 | LEU A 319LEU A 343ASN A 346SER A 390LEU A 365 | NoneNoneNone ZN A 905 (-3.5A)None | 1.19A | 5mwyA-4mnaA:undetectable | 5mwyA-4mnaA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mym | GLYOXALASE/BLEOMYCINRESISTANCEPROTEIN/DIOXYGENASE (Nocardioidessp. JS614) |
PF00903(Glyoxalase) | 5 | LEU A 14LEU A 53SER A 36SER A 35LEU A 34 | None | 0.77A | 5mwyA-4mymA:undetectable | 5mwyA-4mymA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n1y | ESTROGEN RECEPTOR (Crassostreagigas) |
PF00104(Hormone_recep) | 6 | LEU A 280LEU A 283ALA A 287TRP A 320MET A 321MET A 358 | None | 0.81A | 5mwyA-4n1yA:28.5 | 5mwyA-4n1yA:25.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o7z | PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (Pyrococcushorikoshii) |
PF01259(SAICAR_synt) | 5 | LEU A 48LEU A 52ASN A 49LEU A 164LEU A 208 | None | 1.20A | 5mwyA-4o7zA:undetectable | 5mwyA-4o7zA:19.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p6w | GLUCOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 6 | LEU A 563ASN A 564TRP A 600MET A 601LEU A 608LEU A 732 | MOF A 801 (-3.9A)MOF A 801 (-3.0A)NoneMOF A 801 (-3.7A)MOF A 801 ( 4.6A)MOF A 801 ( 4.2A) | 0.53A | 5mwyA-4p6wA:35.3 | 5mwyA-4p6wA:52.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4per | RIBONUCLEASEINHIBITOR (Gallus gallus) |
PF13516(LRR_6) | 5 | LEU A 185LEU A 157ASN A 158ALA A 159LEU A 167 | None | 1.12A | 5mwyA-4perA:undetectable | 5mwyA-4perA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pwv | P450 MONOOXYGENASE (Streptomycessp. Acta 2897) |
PF00067(p450) | 5 | LEU A 172LEU A 175ASN A 176ALA A 179LEU A 200 | None | 0.96A | 5mwyA-4pwvA:undetectable | 5mwyA-4pwvA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q3i | OSSERK2 D128N (Oryza sativa) |
PF08263(LRRNT_2)PF11921(DUF3439) | 5 | LEU A 129LEU A 153ALA A 176LEU A 166LEU A 148 | None | 1.11A | 5mwyA-4q3iA:undetectable | 5mwyA-4q3iA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qik | ROQUIN-1 (Homo sapiens) |
no annotation | 5 | LEU A 183SER A 305SER A 304LEU A 307MET A 317 | None CL A 505 (-3.7A)NoneNoneNone | 1.11A | 5mwyA-4qikA:undetectable | 5mwyA-4qikA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rgq | GLYCEROL-1-PHOSPHATEDEHYDROGENASE (Methanocaldococcusjannaschii) |
PF13685(Fe-ADH_2) | 5 | LEU A 328LEU A 303ALA A 306SER A 229LEU A 232 | EDO A 411 ( 4.5A)NoneNoneNoneNone | 1.12A | 5mwyA-4rgqA:undetectable | 5mwyA-4rgqA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4txa | ROQUIN-1 (Mus musculus) |
PF13445(zf-RING_UBOX) | 5 | LEU A 183SER A 305SER A 304LEU A 307MET A 317 | None | 1.15A | 5mwyA-4txaA:undetectable | 5mwyA-4txaA:20.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4udb | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 7 | ALA A 773TRP A 806MET A 807SER A 811LEU A 814MET A 852LEU A 938 | CV7 A1987 (-3.5A)NoneCV7 A1987 ( 3.9A)NoneCV7 A1987 ( 4.0A)CV7 A1987 ( 3.7A)CV7 A1987 ( 3.9A) | 0.72A | 5mwyA-4udbA:37.6 | 5mwyA-4udbA:99.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4udb | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 9 | LEU A 766LEU A 769ASN A 770ALA A 773TRP A 806MET A 807SER A 811LEU A 814LEU A 938 | CV7 A1987 (-3.6A)CV7 A1987 (-4.1A)CV7 A1987 (-3.1A)CV7 A1987 (-3.5A)NoneCV7 A1987 ( 3.9A)NoneCV7 A1987 ( 4.0A)CV7 A1987 ( 3.9A) | 0.33A | 5mwyA-4udbA:37.6 | 5mwyA-4udbA:99.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x0o | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 PROTEIN 2 (Vibrio cholerae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | LEU A 346LEU A 349ALA A 352LEU A 147LEU A 29 | None | 1.23A | 5mwyA-4x0oA:undetectable | 5mwyA-4x0oA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yub | NICOTINATEPHOSPHORIBOSYLTRANSFERASE (Homo sapiens) |
no annotation | 5 | LEU A 121LEU A 109SER A 493LEU A 496LEU A 56 | None | 1.13A | 5mwyA-4yubA:undetectable | 5mwyA-4yubA:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zlc | ROQUIN-2 (Homo sapiens) |
no annotation | 5 | LEU A 180SER A 302SER A 301LEU A 304MET A 314 | None | 1.12A | 5mwyA-4zlcA:undetectable | 5mwyA-4zlcA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bv8 | VON WILLEBRANDFACTOR (Homo sapiens) |
PF00092(VWA)PF16164(VWA_N2) | 5 | LEU A1282LEU A1384ALA A1386SER A1442LEU A1440 | None | 0.95A | 5mwyA-5bv8A:undetectable | 5mwyA-5bv8A:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ffx | MARR FAMILYREGULATORY PROTEIN (Staphylococcusaureus) |
PF12802(MarR_2) | 5 | LEU A 68LEU A 71SER A 96LEU A 100LEU A 93 | None | 1.06A | 5mwyA-5ffxA:undetectable | 5mwyA-5ffxA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gms | ESTERASE (unculturedbacterium) |
PF07859(Abhydrolase_3) | 5 | LEU A 103LEU A 72ALA A 140LEU A 158LEU A 130 | None | 1.21A | 5mwyA-5gmsA:undetectable | 5mwyA-5gmsA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gr8 | LEUCINE-RICH REPEATRECEPTOR-LIKEPROTEIN KINASE PEPR1 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13855(LRR_8) | 5 | LEU A 359LEU A 344SER A 323LEU A 322LEU A 351 | None | 1.22A | 5mwyA-5gr8A:undetectable | 5mwyA-5gr8A:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kij | ENDOPLASMICRETICULUMMANNOSYL-OLIGOSACCHARIDE1,2-ALPHA-MANNOSIDASE (Homo sapiens) |
PF01532(Glyco_hydro_47) | 5 | LEU A 336LEU A 339ALA A 342SER A 349LEU A 350 | None | 1.18A | 5mwyA-5kijA:undetectable | 5mwyA-5kijA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kkb | MANNOSYL-OLIGOSACCHARIDE1,2-ALPHA-MANNOSIDASE IA (Mus musculus) |
PF01532(Glyco_hydro_47) | 5 | LEU A 616LEU A 613ALA A 610SER A 606LEU A 546 | None | 1.07A | 5mwyA-5kkbA:undetectable | 5mwyA-5kkbA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mwp | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
no annotation | 11 | LEU A 766LEU A 769ASN A 770ALA A 773TRP A 806MET A 807SER A 810LEU A 814MET A 845MET A 852LEU A 938 | ECV A1101 ( 3.9A)ECV A1101 (-4.7A)ECV A1101 (-3.1A)ECV A1101 (-3.8A)NoneECV A1101 (-3.6A)ECV A1101 (-3.4A)ECV A1101 (-4.1A)ECV A1101 (-4.0A)ECV A1101 (-3.7A)ECV A1101 ( 4.3A) | 0.42A | 5mwyA-5mwpA:43.2 | 5mwyA-5mwpA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mwp | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
no annotation | 11 | LEU A 766LEU A 769ASN A 770ALA A 773TRP A 806MET A 807SER A 811LEU A 814MET A 845MET A 852LEU A 938 | ECV A1101 ( 3.9A)ECV A1101 (-4.7A)ECV A1101 (-3.1A)ECV A1101 (-3.8A)NoneECV A1101 (-3.6A)ECV A1101 (-3.0A)ECV A1101 (-4.1A)ECV A1101 (-4.0A)ECV A1101 (-3.7A)ECV A1101 ( 4.3A) | 0.42A | 5mwyA-5mwpA:43.2 | 5mwyA-5mwpA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ogz | - (-) |
no annotation | 5 | LEU A 223LEU A 221ASN A 222SER A 194LEU A 198 | None | 1.21A | 5mwyA-5ogzA:undetectable | 5mwyA-5ogzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5opj | RHAMNOGALACTURONANLYASE (Bacteroidesthetaiotaomicron) |
no annotation | 5 | LEU A 186LEU A 118ASN A 119SER A 62MET A 190 | None | 1.19A | 5mwyA-5opjA:undetectable | 5mwyA-5opjA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 298ALA A 302TRP A 335MET A 336LEU A 343 | EST A 601 (-4.1A)EST A 601 ( 3.9A)NoneEST A 601 ( 3.7A)EST A 601 ( 4.4A) | 0.57A | 5mwyA-5toaA:25.5 | 5mwyA-5toaA:26.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tov | ADENOSYLHOMOCYSTEINASE (Thermotogamaritima) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 18ASN A 19ALA A 22SER A 54LEU A 53 | None | 0.59A | 5mwyA-5tovA:undetectable | 5mwyA-5tovA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4t | PUTATIVE GENTAMICINMETHYLTRANSFERASE (Micromonosporaechinospora) |
no annotation | 5 | LEU A 18LEU A 21ALA A 24LEU A 40LEU A 91 | None | 1.23A | 5mwyA-5u4tA:undetectable | 5mwyA-5u4tA:21.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ufs | ANCESTRALGLUCOCORTICOIDRECEPTOR2 (unidentified) |
PF00104(Hormone_recep) | 6 | LEU A 32ASN A 33TRP A 69MET A 70LEU A 77LEU A 201 | 1TA A 301 (-3.5A)1TA A 301 (-3.0A)None1TA A 301 ( 3.1A)1TA A 301 ( 3.4A)1TA A 301 ( 3.8A) | 0.42A | 5mwyA-5ufsA:36.9 | 5mwyA-5ufsA:53.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ufs | ANCESTRALGLUCOCORTICOIDRECEPTOR2 (unidentified) |
PF00104(Hormone_recep) | 5 | TRP A 69MET A 70LEU A 77MET A 115LEU A 201 | None1TA A 301 ( 3.1A)1TA A 301 ( 3.4A)1TA A 301 ( 2.8A)1TA A 301 ( 3.8A) | 1.01A | 5mwyA-5ufsA:36.9 | 5mwyA-5ufsA:53.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vym | BETA-GALACTOSIDASEBGAB (Bifidobacteriumadolescentis) |
PF08532(Glyco_hydro_42M) | 5 | LEU A 222LEU A 217ALA A 150SER A 144LEU A 142 | None | 1.22A | 5mwyA-5vymA:undetectable | 5mwyA-5vymA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w7z | DNA POLYMERASE IIISUBUNIT BETA (Rickettsiaconorii) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 5 | LEU A 108LEU A 75SER A 47SER A 46LEU A 45 | None | 1.21A | 5mwyA-5w7zA:undetectable | 5mwyA-5w7zA:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wtk | CRISPR-ASSOCIATEDENDORIBONUCLEASEC2C2 (Leptotrichiashahii) |
no annotation | 5 | LEU A 383LEU A 463SER A 466SER A 469LEU A 375 | None | 1.17A | 5mwyA-5wtkA:undetectable | 5mwyA-5wtkA:11.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bwm | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY VMEMBER 2 (Oryctolaguscuniculus) |
no annotation | 5 | LEU A 248LEU A 251ALA A 255SER A 262LEU A 264 | None | 1.02A | 5mwyA-6bwmA:undetectable | 5mwyA-6bwmA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c3p | ATP-BINDING CASSETTESUB-FAMILY C MEMBER8 (Homo sapiens) |
no annotation | 5 | LEU E 318SER E 581SER E 579LEU E 582LEU E 456 | None | 1.20A | 5mwyA-6c3pE:undetectable | 5mwyA-6c3pE:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cgm | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (Bacillussubtilis) |
no annotation | 5 | LEU A 173LEU A 201SER A 279LEU A 278LEU A 381 | None | 0.88A | 5mwyA-6cgmA:undetectable | 5mwyA-6cgmA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fg8 | PROBABLE INACTIVERECEPTOR KINASEAT1G27190 (Arabidopsisthaliana) |
no annotation | 5 | LEU B 165LEU B 150SER B 129LEU B 128LEU B 157 | None | 1.11A | 5mwyA-6fg8B:undetectable | 5mwyA-6fg8B:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g3w | PROBABLE INACTIVERECEPTOR KINASEAT1G27190 (Arabidopsisthaliana) |
no annotation | 5 | LEU B 103LEU B 128ASN B 131SER B 175LEU B 150 | None | 1.20A | 5mwyA-6g3wB:undetectable | 5mwyA-6g3wB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g3w | PROBABLE INACTIVERECEPTOR KINASEAT1G27190 (Arabidopsisthaliana) |
no annotation | 5 | LEU B 165LEU B 150SER B 129LEU B 128LEU B 157 | None | 1.12A | 5mwyA-6g3wB:undetectable | 5mwyA-6g3wB:undetectable |