SIMILAR PATTERNS OF AMINO ACIDS FOR 5MWY_A_YNUA1101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA

(Homo sapiens) 		PF00042
(Globin) 		5 LEU A  81
ALA A 135
SER A 129
LEU A 130
LEU A   3
 None
 1.09A 5mwyA-1ch4A:
undetectable		 5mwyA-1ch4A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		5 LEU A 341
ALA A 486
SER A 398
LEU A 400
MET A 417
 None
 1.18A 5mwyA-1cjyA:
undetectable		 5mwyA-1cjyA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 LEU A 285
LEU A 175
ALA A 252
TRP A 123
LEU A 245
 None
 1.11A 5mwyA-1csjA:
undetectable		 5mwyA-1csjA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		5 LEU A 329
LEU A 353
ALA A 384
SER A 400
LEU A 399
 None
 1.16A 5mwyA-1dabA:
undetectable		 5mwyA-1dabA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fns VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		5 LEU A 519
LEU A 621
ALA A 623
SER A 679
LEU A 677
 None
 0.98A 5mwyA-1fnsA:
undetectable		 5mwyA-1fnsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		5 LEU A 182
LEU A 253
LEU A 285
MET A 388
LEU A 325
 None
 1.10A 5mwyA-1hxjA:
undetectable		 5mwyA-1hxjA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		5 LEU A1081
LEU A1078
ASN A1101
SER A1095
LEU A1093
 None
 1.15A 5mwyA-1jl5A:
undetectable		 5mwyA-1jl5A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 158
LEU A 155
ASN A 154
ALA A 151
LEU A 132
 None
 1.16A 5mwyA-1lbkA:
undetectable		 5mwyA-1lbkA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi1 NEUROBEACHIN

(Homo sapiens) 		PF02138
(Beach)
PF14844
(PH_BEACH) 		5 LEU A2290
LEU A2293
ASN A2294
ALA A2297
LEU A2546
 None
 0.53A 5mwyA-1mi1A:
undetectable		 5mwyA-1mi1A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
ALA A 350
TRP A 383
LEU A 391
MET A 421
 EST  A   1 (-4.4A)
EST  A   1 ( 3.7A)
None
EST  A   1 ( 3.9A)
EST  A   1 ( 4.3A)
 0.67A 5mwyA-1pcgA:
26.9		 5mwyA-1pcgA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spg HEMOGLOBIN

(Leiostomus
xanthurus) 		PF00042
(Globin) 		5 LEU A 131
LEU A 134
ALA A 137
SER A  86
LEU A  85
 None
None
None
None
HEM  A 144 ( 4.9A)
 1.20A 5mwyA-1spgA:
undetectable		 5mwyA-1spgA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t77 LIPOPOLYSACCHARIDE-R
ESPONSIVE AND
BEIGE-LIKE ANCHOR
PROTEIN

(Homo sapiens) 		PF02138
(Beach)
PF14844
(PH_BEACH) 		5 LEU A2226
LEU A2229
ASN A2230
ALA A2233
LEU A2482
 None
 0.52A 5mwyA-1t77A:
undetectable		 5mwyA-1t77A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8w AMP NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1)
PF10423
(AMNp_N) 		5 LEU A 202
LEU A 275
ALA A 262
SER A 232
LEU A 231
 None
 1.21A 5mwyA-1t8wA:
undetectable		 5mwyA-1t8wA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkh PUTATIVE SERINE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF07859
(Abhydrolase_3) 		5 LEU A 138
LEU A 141
SER A 200
SER A 197
LEU A 196
 None
 1.21A 5mwyA-1vkhA:
undetectable		 5mwyA-1vkhA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x55 ASPARAGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 404
SER A 205
LEU A 206
MET A 250
LEU A 149
 None
 1.23A 5mwyA-1x55A:
undetectable		 5mwyA-1x55A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Homo sapiens) 		PF01532
(Glyco_hydro_47) 		5 LEU A 336
LEU A 339
ALA A 342
SER A 349
LEU A 350
 None
 1.11A 5mwyA-1x9dA:
undetectable		 5mwyA-1x9dA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 327
LEU A 324
ALA A 396
LEU A 401
LEU A 380
 None
 1.16A 5mwyA-1xb7A:
26.5		 5mwyA-1xb7A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yg2 GENE ACTIVATOR APHA

(Vibrio cholerae) 		PF03551
(PadR)
PF10400
(Vir_act_alpha_C) 		5 LEU A 172
LEU A 175
ASN A 176
ALA A 179
SER A 107
 None
 0.95A 5mwyA-1yg2A:
undetectable		 5mwyA-1yg2A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjg SURFACE PROTEIN VSPA

(Borrelia
turicatae) 		PF01441
(Lipoprotein_6) 		5 LEU A 176
LEU A 179
ASN A 180
LEU A 109
LEU A  64
 None
 1.22A 5mwyA-1yjgA:
undetectable		 5mwyA-1yjgA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2

(Archaeoglobus
fulgidus) 		PF02552
(CO_dh) 		5 LEU A  40
LEU A 113
ALA A 138
SER A 152
LEU A  22
 None
 1.23A 5mwyA-1ytlA:
undetectable		 5mwyA-1ytlA:
17.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 701
LEU A 704
ASN A 705
TRP A 741
MET A 742
MET A 780
MET A 787
LEU A 873
 None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
None
BHM  A   1 ( 4.0A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.4A)
 1.23A 5mwyA-2ax9A:
36.4		 5mwyA-2ax9A:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus scrofa) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 156
LEU A 153
ASN A 152
ALA A 149
LEU A 130
 None
 1.14A 5mwyA-2gsrA:
undetectable		 5mwyA-2gsrA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijr HYPOTHETICAL PROTEIN
API92

(Yersinia
pseudotuberculosis) 		PF06924
(DUF1281) 		5 LEU A 222
LEU A 224
MET A  21
MET A 169
LEU A 241
 None
 1.17A 5mwyA-2ijrA:
undetectable		 5mwyA-2ijrA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 LEU A  88
LEU A  87
SER A 153
LEU A 155
MET A 324
 None
 1.19A 5mwyA-2ip2A:
undetectable		 5mwyA-2ip2A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nc8 LIPOPROTEIN LPPM

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A  60
ALA A  71
SER A  88
SER A  41
LEU A  90
 None
 1.20A 5mwyA-2nc8A:
undetectable		 5mwyA-2nc8A:
23.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		6 ALA A  36
TRP A  69
MET A  70
LEU A  77
MET A 115
LEU A 201
 1CA  A 247 (-3.6A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.9A)
1CA  A 247 ( 3.7A)
1CA  A 247 ( 4.2A)
 0.80A 5mwyA-2q3yA:
39.0		 5mwyA-2q3yA:
72.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		9 LEU A  29
LEU A  32
ASN A  33
ALA A  36
TRP A  69
MET A  70
LEU A  77
MET A 108
LEU A 201
 1CA  A 247 ( 3.6A)
1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 (-3.6A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.9A)
1CA  A 247 ( 4.2A)
 0.33A 5mwyA-2q3yA:
39.0		 5mwyA-2q3yA:
72.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qga ADENYLOSUCCINATE
LYASE

(Plasmodium
vivax) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 LEU B 259
ASN B 263
SER B 357
LEU B 359
LEU B 352
 None
 1.17A 5mwyA-2qgaB:
undetectable		 5mwyA-2qgaB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1h HEMOGLOBIN SUBUNIT
ALPHA-4

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		5 LEU A 130
LEU A 133
ALA A 136
SER A  85
LEU A  84
 None
None
None
None
HEM  A 143 (-4.7A)
 1.16A 5mwyA-2r1hA:
undetectable		 5mwyA-2r1hA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		5 LEU A   8
LEU A  12
ASN A   9
LEU A 260
LEU A 130
 None
 1.21A 5mwyA-2x5fA:
undetectable		 5mwyA-2x5fA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 LEU A 285
LEU A 175
ALA A 252
TRP A 123
LEU A 245
 None
 1.21A 5mwyA-2xymA:
undetectable		 5mwyA-2xymA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 269
LEU A 272
MET A 251
LEU A 221
LEU A 227
 None
 1.05A 5mwyA-2z81A:
undetectable		 5mwyA-2z81A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 269
LEU A 272
MET A 251
SER A 249
LEU A 227
 None
 1.04A 5mwyA-2z81A:
undetectable		 5mwyA-2z81A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z84 UFM1-SPECIFIC
PROTEASE 1

(Mus musculus) 		PF07910
(Peptidase_C78) 		5 LEU A  75
LEU A  78
ALA A  81
SER A 105
LEU A 108
 None
 1.17A 5mwyA-2z84A:
undetectable		 5mwyA-2z84A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE

(Pseudomonas sp.
ATCC 19121) 		PF00155
(Aminotran_1_2) 		5 LEU A 281
ALA A 272
SER A 266
LEU A 267
LEU A 238
 None
 1.21A 5mwyA-2zy2A:
undetectable		 5mwyA-2zy2A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a74 LYSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		6 LEU A 283
LEU A 287
ASN A 286
ALA A 289
LEU A 471
LEU A 405
 None
 1.35A 5mwyA-3a74A:
undetectable		 5mwyA-3a74A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		5 LEU A 171
LEU A 153
SER A 177
LEU A 179
LEU A 237
 None
 1.19A 5mwyA-3cwcA:
undetectable		 5mwyA-3cwcA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9p PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF12134
(PRP8_domainIV) 		5 LEU A2015
LEU A2012
TRP A1995
LEU A1889
LEU A2039
 None
 1.09A 5mwyA-3e9pA:
undetectable		 5mwyA-3e9pA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eco MEPR

(Staphylococcus
aureus) 		PF12802
(MarR_2) 		5 LEU A  68
LEU A  71
SER A  96
LEU A 100
LEU A  93
 None
 0.98A 5mwyA-3ecoA:
undetectable		 5mwyA-3ecoA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enu PUTATIVE
UNCHARACTERIZED
PROTEIN

(Nitrosospira
multiformis) 		PF08964
(Crystall_3) 		5 LEU A 137
LEU A  98
ALA A 117
SER A  89
LEU A 122
 None
 1.13A 5mwyA-3enuA:
undetectable		 5mwyA-3enuA:
17.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 715
LEU A 718
ASN A 719
TRP A 755
MET A 756
LEU A 763
LEU A 887
 WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
None
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-4.0A)
 0.94A 5mwyA-3kbaA:
36.1		 5mwyA-3kbaA:
51.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ls1 SLL1638 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF05757
(PsbQ) 		5 LEU A  79
ALA A 105
SER A 140
LEU A 142
MET A  55
 None
 1.21A 5mwyA-3ls1A:
undetectable		 5mwyA-3ls1A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxm ASPARTATE
CARBAMOYLTRANSFERASE

(Yersinia pestis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A 216
SER A 253
SER A 252
LEU A 255
MET A 228
 None
 1.04A 5mwyA-3lxmA:
undetectable		 5mwyA-3lxmA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n90 THYLAKOID LUMENAL 15
KDA PROTEIN 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00805
(Pentapeptide) 		5 LEU A 194
LEU A 202
ALA A 206
MET A 173
LEU A 168
 None
 1.14A 5mwyA-3n90A:
undetectable		 5mwyA-3n90A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o76 GLUTATHIONE
S-TRANSFERASE P 1

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 158
LEU A 155
ASN A 154
ALA A 151
LEU A 132
 None
 1.16A 5mwyA-3o76A:
undetectable		 5mwyA-3o76A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		5 LEU A  86
LEU A  31
LEU A 136
MET A 148
LEU A  79
 None
 1.20A 5mwyA-3pvtA:
2.0		 5mwyA-3pvtA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgh RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 LEU A 285
LEU A 175
ALA A 252
TRP A 123
LEU A 245
 None
 1.11A 5mwyA-3qghA:
undetectable		 5mwyA-3qghA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 LEU A 222
ALA A 216
SER A 250
LEU A 243
MET A 239
 None
 1.23A 5mwyA-3rblA:
undetectable		 5mwyA-3rblA:
20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		8 LEU A  29
LEU A  32
ASN A  33
TRP A  69
MET A  70
LEU A  77
MET A 108
LEU A 201
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 0.34A 5mwyA-3ry9A:
38.3		 5mwyA-3ry9A:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 TRP A  69
MET A  70
LEU A  77
MET A 115
LEU A 201
 None
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 0.86A 5mwyA-3ry9A:
38.3		 5mwyA-3ry9A:
59.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbg PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF12134
(PRP8_domainIV) 		5 LEU A2015
LEU A2012
TRP A1995
LEU A1889
LEU A2039
 None
 1.00A 5mwyA-3sbgA:
undetectable		 5mwyA-3sbgA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh7 BETA-GLUCOSIDASE

(metagenomes) 		PF00232
(Glyco_hydro_1) 		5 LEU A 224
LEU A 222
ASN A 223
SER A 194
LEU A 198
 None
 1.19A 5mwyA-3wh7A:
undetectable		 5mwyA-3wh7A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		5 LEU A 122
SER A 128
SER A 131
LEU A 130
LEU A  90
 None
 1.18A 5mwyA-3wrcA:
undetectable		 5mwyA-3wrcA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		5 LEU A 676
ALA A 688
SER A 711
LEU A 710
LEU A 734
 None
 1.19A 5mwyA-3x1lA:
undetectable		 5mwyA-3x1lA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b16 CHITINASE LIKE
LECTIN

(Tamarindus
indica) 		PF00704
(Glyco_hydro_18) 		5 LEU A 136
LEU A 141
ALA A 172
SER A 157
LEU A 156
 None
 1.17A 5mwyA-4b16A:
undetectable		 5mwyA-4b16A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Thermus
thermophilus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 LEU A  73
LEU A  45
SER A  20
LEU A  19
LEU A 108
 None
 1.17A 5mwyA-4ev0A:
undetectable		 5mwyA-4ev0A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		PF13855
(LRR_8) 		5 LEU A 343
LEU A 320
ALA A 322
LEU A 292
LEU A 350
 None
None
CL  A 503 (-4.4A)
None
None
 1.21A 5mwyA-4fcgA:
undetectable		 5mwyA-4fcgA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2c DYP2

(Amycolatopsis
sp. ATCC 39116) 		no annotation 5 LEU A 466
LEU A  57
ASN A  58
MET A  64
LEU A 141
 None
None
ACT  A 514 (-3.4A)
None
None
 1.19A 5mwyA-4g2cA:
undetectable		 5mwyA-4g2cA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		5 LEU A  37
LEU A  35
ASN A  36
LEU A 200
LEU A 145
 None
 1.15A 5mwyA-4ifqA:
undetectable		 5mwyA-4ifqA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 143
LEU A 167
ALA A 190
SER A 211
LEU A 209
 None
 1.23A 5mwyA-4kngA:
undetectable		 5mwyA-4kngA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 319
LEU A 343
ASN A 346
SER A 390
LEU A 365
 None
None
None
ZN  A 905 (-3.5A)
None
 1.19A 5mwyA-4mnaA:
undetectable		 5mwyA-4mnaA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Nocardioides
sp. JS614) 		PF00903
(Glyoxalase) 		5 LEU A  14
LEU A  53
SER A  36
SER A  35
LEU A  34
 None
 0.77A 5mwyA-4mymA:
undetectable		 5mwyA-4mymA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 280
LEU A 283
ALA A 287
TRP A 320
MET A 321
MET A 358
 None
 0.81A 5mwyA-4n1yA:
28.5		 5mwyA-4n1yA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Pyrococcus
horikoshii) 		PF01259
(SAICAR_synt) 		5 LEU A  48
LEU A  52
ASN A  49
LEU A 164
LEU A 208
 None
 1.20A 5mwyA-4o7zA:
undetectable		 5mwyA-4o7zA:
19.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 563
ASN A 564
TRP A 600
MET A 601
LEU A 608
LEU A 732
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
None
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 ( 4.2A)
 0.53A 5mwyA-4p6wA:
35.3		 5mwyA-4p6wA:
52.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		5 LEU A 185
LEU A 157
ASN A 158
ALA A 159
LEU A 167
 None
 1.12A 5mwyA-4perA:
undetectable		 5mwyA-4perA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwv P450 MONOOXYGENASE

(Streptomyces
sp. Acta 2897) 		PF00067
(p450) 		5 LEU A 172
LEU A 175
ASN A 176
ALA A 179
LEU A 200
 None
 0.96A 5mwyA-4pwvA:
undetectable		 5mwyA-4pwvA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3i OSSERK2 D128N

(Oryza sativa) 		PF08263
(LRRNT_2)
PF11921
(DUF3439) 		5 LEU A 129
LEU A 153
ALA A 176
LEU A 166
LEU A 148
 None
 1.11A 5mwyA-4q3iA:
undetectable		 5mwyA-4q3iA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qik ROQUIN-1

(Homo sapiens) 		no annotation 5 LEU A 183
SER A 305
SER A 304
LEU A 307
MET A 317
 None
CL  A 505 (-3.7A)
None
None
None
 1.11A 5mwyA-4qikA:
undetectable		 5mwyA-4qikA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF13685
(Fe-ADH_2) 		5 LEU A 328
LEU A 303
ALA A 306
SER A 229
LEU A 232
 EDO  A 411 ( 4.5A)
None
None
None
None
 1.12A 5mwyA-4rgqA:
undetectable		 5mwyA-4rgqA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		5 LEU A 183
SER A 305
SER A 304
LEU A 307
MET A 317
 None
 1.15A 5mwyA-4txaA:
undetectable		 5mwyA-4txaA:
20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ALA A 773
TRP A 806
MET A 807
SER A 811
LEU A 814
MET A 852
LEU A 938
 CV7  A1987 (-3.5A)
None
CV7  A1987 ( 3.9A)
None
CV7  A1987 ( 4.0A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
 0.72A 5mwyA-4udbA:
37.6		 5mwyA-4udbA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 766
LEU A 769
ASN A 770
ALA A 773
TRP A 806
MET A 807
SER A 811
LEU A 814
LEU A 938
 CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 (-3.5A)
None
CV7  A1987 ( 3.9A)
None
CV7  A1987 ( 4.0A)
CV7  A1987 ( 3.9A)
 0.33A 5mwyA-4udbA:
37.6		 5mwyA-4udbA:
99.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 346
LEU A 349
ALA A 352
LEU A 147
LEU A  29
 None
 1.23A 5mwyA-4x0oA:
undetectable		 5mwyA-4x0oA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		no annotation 5 LEU A 121
LEU A 109
SER A 493
LEU A 496
LEU A  56
 None
 1.13A 5mwyA-4yubA:
undetectable		 5mwyA-4yubA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlc ROQUIN-2

(Homo sapiens) 		no annotation 5 LEU A 180
SER A 302
SER A 301
LEU A 304
MET A 314
 None
 1.12A 5mwyA-4zlcA:
undetectable		 5mwyA-4zlcA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv8 VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA)
PF16164
(VWA_N2) 		5 LEU A1282
LEU A1384
ALA A1386
SER A1442
LEU A1440
 None
 0.95A 5mwyA-5bv8A:
undetectable		 5mwyA-5bv8A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffx MARR FAMILY
REGULATORY PROTEIN

(Staphylococcus
aureus) 		PF12802
(MarR_2) 		5 LEU A  68
LEU A  71
SER A  96
LEU A 100
LEU A  93
 None
 1.06A 5mwyA-5ffxA:
undetectable		 5mwyA-5ffxA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gms ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 LEU A 103
LEU A  72
ALA A 140
LEU A 158
LEU A 130
 None
 1.21A 5mwyA-5gmsA:
undetectable		 5mwyA-5gmsA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A 359
LEU A 344
SER A 323
LEU A 322
LEU A 351
 None
 1.22A 5mwyA-5gr8A:
undetectable		 5mwyA-5gr8A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Homo sapiens) 		PF01532
(Glyco_hydro_47) 		5 LEU A 336
LEU A 339
ALA A 342
SER A 349
LEU A 350
 None
 1.18A 5mwyA-5kijA:
undetectable		 5mwyA-5kijA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA

(Mus musculus) 		PF01532
(Glyco_hydro_47) 		5 LEU A 616
LEU A 613
ALA A 610
SER A 606
LEU A 546
 None
 1.07A 5mwyA-5kkbA:
undetectable		 5mwyA-5kkbA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 11 LEU A 766
LEU A 769
ASN A 770
ALA A 773
TRP A 806
MET A 807
SER A 810
LEU A 814
MET A 845
MET A 852
LEU A 938
 ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 (-3.8A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-3.4A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
 0.42A 5mwyA-5mwpA:
43.2		 5mwyA-5mwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 11 LEU A 766
LEU A 769
ASN A 770
ALA A 773
TRP A 806
MET A 807
SER A 811
LEU A 814
MET A 845
MET A 852
LEU A 938
 ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 (-3.8A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-3.0A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
 0.42A 5mwyA-5mwpA:
43.2		 5mwyA-5mwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogz -

(-) 		no annotation 5 LEU A 223
LEU A 221
ASN A 222
SER A 194
LEU A 198
 None
 1.21A 5mwyA-5ogzA:
undetectable		 5mwyA-5ogzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 186
LEU A 118
ASN A 119
SER A  62
MET A 190
 None
 1.19A 5mwyA-5opjA:
undetectable		 5mwyA-5opjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 298
ALA A 302
TRP A 335
MET A 336
LEU A 343
 EST  A 601 (-4.1A)
EST  A 601 ( 3.9A)
None
EST  A 601 ( 3.7A)
EST  A 601 ( 4.4A)
 0.57A 5mwyA-5toaA:
25.5		 5mwyA-5toaA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tov ADENOSYLHOMOCYSTEINA
SE

(Thermotoga
maritima) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A  18
ASN A  19
ALA A  22
SER A  54
LEU A  53
 None
 0.59A 5mwyA-5tovA:
undetectable		 5mwyA-5tovA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4t PUTATIVE GENTAMICIN
METHYLTRANSFERASE

(Micromonospora
echinospora) 		no annotation 5 LEU A  18
LEU A  21
ALA A  24
LEU A  40
LEU A  91
 None
 1.23A 5mwyA-5u4tA:
undetectable		 5mwyA-5u4tA:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  32
ASN A  33
TRP A  69
MET A  70
LEU A  77
LEU A 201
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 ( 3.8A)
 0.42A 5mwyA-5ufsA:
36.9		 5mwyA-5ufsA:
53.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 TRP A  69
MET A  70
LEU A  77
MET A 115
LEU A 201
 None
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 ( 2.8A)
1TA  A 301 ( 3.8A)
 1.01A 5mwyA-5ufsA:
36.9		 5mwyA-5ufsA:
53.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vym BETA-GALACTOSIDASE
BGAB

(Bifidobacterium
adolescentis) 		PF08532
(Glyco_hydro_42M) 		5 LEU A 222
LEU A 217
ALA A 150
SER A 144
LEU A 142
 None
 1.22A 5mwyA-5vymA:
undetectable		 5mwyA-5vymA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7z DNA POLYMERASE III
SUBUNIT BETA

(Rickettsia
conorii) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 LEU A 108
LEU A  75
SER A  47
SER A  46
LEU A  45
 None
 1.21A 5mwyA-5w7zA:
undetectable		 5mwyA-5w7zA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2

(Leptotrichia
shahii) 		no annotation 5 LEU A 383
LEU A 463
SER A 466
SER A 469
LEU A 375
 None
 1.17A 5mwyA-5wtkA:
undetectable		 5mwyA-5wtkA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Oryctolagus
cuniculus) 		no annotation 5 LEU A 248
LEU A 251
ALA A 255
SER A 262
LEU A 264
 None
 1.02A 5mwyA-6bwmA:
undetectable		 5mwyA-6bwmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8

(Homo sapiens) 		no annotation 5 LEU E 318
SER E 581
SER E 579
LEU E 582
LEU E 456
 None
 1.20A 5mwyA-6c3pE:
undetectable		 5mwyA-6c3pE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 5 LEU A 173
LEU A 201
SER A 279
LEU A 278
LEU A 381
 None
 0.88A 5mwyA-6cgmA:
undetectable		 5mwyA-6cgmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg8 PROBABLE INACTIVE
RECEPTOR KINASE
AT1G27190

(Arabidopsis
thaliana) 		no annotation 5 LEU B 165
LEU B 150
SER B 129
LEU B 128
LEU B 157
 None
 1.11A 5mwyA-6fg8B:
undetectable		 5mwyA-6fg8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3w PROBABLE INACTIVE
RECEPTOR KINASE
AT1G27190

(Arabidopsis
thaliana) 		no annotation 5 LEU B 103
LEU B 128
ASN B 131
SER B 175
LEU B 150
 None
 1.20A 5mwyA-6g3wB:
undetectable		 5mwyA-6g3wB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3w PROBABLE INACTIVE
RECEPTOR KINASE
AT1G27190

(Arabidopsis
thaliana) 		no annotation 5 LEU B 165
LEU B 150
SER B 129
LEU B 128
LEU B 157
 None
 1.12A 5mwyA-6g3wB:
undetectable		 5mwyA-6g3wB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aux SYNAPSIN IA

(Bos taurus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		4 ARG A 328
CYH A 360
THR A 359
PHE A 244
 None
 1.30A 5mwyA-1auxA:
undetectable		 5mwyA-1auxA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq6 XYS1

(Streptomyces
halstedii) 		PF00331
(Glyco_hydro_10) 		4 ARG A 159
PHE A 155
THR A 174
PHE A 224
 None
 1.30A 5mwyA-1nq6A:
undetectable		 5mwyA-1nq6A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi) 		PF05544
(Pro_racemase) 		4 GLN A 241
CYH A 300
THR A 302
PHE A 220
 None
PYC  A 700 (-3.4A)
PYC  A 700 (-2.6A)
None
 1.22A 5mwyA-1w61A:
undetectable		 5mwyA-1w61A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w74 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A

(Mycobacterium
tuberculosis) 		PF00160
(Pro_isomerase) 		4 GLN A  81
ARG A  73
THR A  54
PHE A  65
 None
 1.38A 5mwyA-1w74A:
undetectable		 5mwyA-1w74A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wer P120GAP

(Homo sapiens) 		PF00616
(RasGAP) 		4 ARG A 776
CYH A1002
THR A1030
PHE A 726
 None
 1.42A 5mwyA-1werA:
undetectable		 5mwyA-1werA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Streptococcus
pneumoniae) 		PF03070
(TENA_THI-4) 		4 GLN A  84
ARG A  80
PHE A  81
PHE A  57
 None
None
None
ACY  A 801 (-3.4A)
 1.32A 5mwyA-1z72A:
undetectable		 5mwyA-1z72A:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 GLN A 711
ARG A 752
PHE A 764
PHE A 891
 BHM  A   1 (-2.2A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
None
 0.54A 5mwyA-2ax9A:
36.4		 5mwyA-2ax9A:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bii NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 GLN A 224
PHE A  87
CYH A 385
PHE A  79
 None
MTV  A1479 (-3.5A)
None
None
 1.24A 5mwyA-2biiA:
undetectable		 5mwyA-2biiA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like) 		4 PHE A 147
CYH A 170
THR A 205
PHE A 134
 None
 1.47A 5mwyA-2cw6A:
undetectable		 5mwyA-2cw6A:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		6 GLN A  39
ARG A  80
PHE A  92
CYH A 205
THR A 208
PHE A 219
 1CA  A 247 (-3.1A)
1CA  A 247 (-3.8A)
None
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.31A 5mwyA-2q3yA:
39.0		 5mwyA-2q3yA:
72.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		4 PHE A  98
CYH A 205
THR A 208
PHE A 219
 None
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 1.21A 5mwyA-2q3yA:
39.0		 5mwyA-2q3yA:
72.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2u XYLOSIDASE/ARABINOSI
DASE

(Selenomonas
ruminantium) 		PF04616
(Glyco_hydro_43)
PF07081
(DUF1349) 		4 GLN A 346
ARG A 386
THR A 106
PHE A  60
 None
 1.29A 5mwyA-3c2uA:
undetectable		 5mwyA-3c2uA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF13847
(Methyltransf_31) 		4 PHE A 101
CYH A  45
THR A  51
PHE A  93
 None
 1.12A 5mwyA-3g5tA:
undetectable		 5mwyA-3g5tA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		4 GLN A 463
PHE A 433
THR A 499
PHE A 487
 None
 1.22A 5mwyA-3ibjA:
undetectable		 5mwyA-3ibjA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		4 GLN A1667
PHE A1674
CYH A1748
THR A1745
 GOL  A 366 (-4.2A)
None
None
None
 1.20A 5mwyA-3ig3A:
undetectable		 5mwyA-3ig3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		4 ARG A 117
PHE A 119
CYH A 134
PHE A  41
 None
 1.45A 5mwyA-3j4sA:
undetectable		 5mwyA-3j4sA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN

(Escherichia
coli) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30) 		4 GLN D 328
PHE D 321
THR D 180
PHE D 145
 None
 1.38A 5mwyA-3k70D:
undetectable		 5mwyA-3k70D:
18.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLN A 725
ARG A 766
PHE A 778
CYH A 891
THR A 894
PHE A 905
 WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
None
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.74A 5mwyA-3kbaA:
36.1		 5mwyA-3kbaA:
51.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		4 GLN A  34
PHE A 253
THR A 115
PHE A 324
 None
LEU  A 601 (-4.2A)
None
None
 1.38A 5mwyA-3mpnA:
undetectable		 5mwyA-3mpnA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE

(Escherichia
coli) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		4 GLN A 201
PHE A  89
THR A 585
PHE A 319
 None
 1.42A 5mwyA-3o98A:
undetectable		 5mwyA-3o98A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pss QNR

(Aeromonas
hydrophila) 		PF00805
(Pentapeptide)
PF13599
(Pentapeptide_4) 		4 ARG A  11
PHE A  32
CYH A  83
PHE A  98
 None
 1.49A 5mwyA-3pssA:
undetectable		 5mwyA-3pssA:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		6 GLN A  39
ARG A  80
PHE A  92
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.29A 5mwyA-3ry9A:
38.1		 5mwyA-3ry9A:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		4 PHE A  98
CYH A 205
THR A 208
PHE A 219
 None
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.33A 5mwyA-3ry9A:
38.1		 5mwyA-3ry9A:
59.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		4 GLN A 778
ARG A 792
CYH A 598
PHE A 846
 None
 1.45A 5mwyA-3s1sA:
undetectable		 5mwyA-3s1sA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 GLN A 588
PHE A 777
THR A 517
PHE A 707
 None
 1.43A 5mwyA-4bedA:
undetectable		 5mwyA-4bedA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 GLN A 296
PHE A 269
CYH A 137
PHE A 186
 None
 1.45A 5mwyA-4eo4A:
undetectable		 5mwyA-4eo4A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Tetrahymena
thermophila) 		PF05028
(PARG_cat) 		4 PHE A 352
CYH A 396
THR A 222
PHE A 230
 None
APR  A 501 (-4.2A)
None
None
 1.42A 5mwyA-4eppA:
undetectable		 5mwyA-4eppA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE

(Prochloron
didemni) 		PF00082
(Peptidase_S8) 		4 PHE A 567
CYH A 620
THR A 623
PHE A 558
 None
 1.43A 5mwyA-4h6xA:
undetectable		 5mwyA-4h6xA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 GLN A 599
PHE A 572
CYH A 450
PHE A 499
 None
 1.43A 5mwyA-4hwtA:
undetectable		 5mwyA-4hwtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7m PROTEIN DOM3Z

(Mus musculus) 		PF08652
(RAI1) 		4 GLN A 339
ARG A 155
THR A 141
PHE A 330
 None
 1.41A 5mwyA-4j7mA:
undetectable		 5mwyA-4j7mA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf8 TRWG COMPONENT OF
TYPE IV SECRETION
SYSTEM

(Bartonella
birtlesii) 		PF04335
(VirB8) 		4 GLN A 104
PHE A 217
THR A 224
PHE A 175
 None
 1.48A 5mwyA-4jf8A:
undetectable		 5mwyA-4jf8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
ACETALDEHYDE
DEHYDROGENASE

(Thermomonospora
curvata;
Thermomonospora
curvata) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm)
PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		4 GLN A 329
CYH B 146
THR B 145
PHE B 189
 None
NAD  B 401 (-3.7A)
None
None
 1.49A 5mwyA-4lrsA:
undetectable		 5mwyA-4lrsA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mj3 HALOALKANE
DEHALOGENASE

(Mycolicibacterium
rhodesiae) 		PF00561
(Abhydrolase_1) 		4 GLN A 270
PHE A 238
THR A 148
PHE A 246
 None
 1.45A 5mwyA-4mj3A:
undetectable		 5mwyA-4mj3A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01425
(Amidase)
PF02934
(GatB_N) 		4 GLN A 184
ARG B 105
CYH A  64
THR A  62
 None
 1.37A 5mwyA-4n0iA:
undetectable		 5mwyA-4n0iA:
20.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLN A 570
ARG A 611
PHE A 623
CYH A 736
THR A 739
PHE A 749
 MOF  A 801 (-2.9A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
 0.36A 5mwyA-4p6wA:
35.3		 5mwyA-4p6wA:
52.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLN A 776
ARG A 817
PHE A 829
CYH A 942
THR A 945
PHE A 956
 CV7  A1987 (-3.0A)
CV7  A1987 (-3.7A)
CV7  A1987 (-4.9A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 0.26A 5mwyA-4udbA:
37.6		 5mwyA-4udbA:
99.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 ARG B  78
CYH A  81
THR A  87
PHE A  97
 None
 1.41A 5mwyA-4wj3B:
undetectable		 5mwyA-4wj3B:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj5 CYCLIC AMP-GMP
SYNTHASE

(Vibrio cholerae) 		no annotation 4 PHE A 337
CYH A 283
THR A 119
PHE A 268
 None
 1.42A 5mwyA-4xj5A:
3.1		 5mwyA-4xj5A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 4 PHE A 333
CYH A 279
THR A 117
PHE A 264
 None
 1.42A 5mwyA-4xj6A:
3.4		 5mwyA-4xj6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp3 MYCOCEROSIC ACID
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF14765
(PS-DH) 		4 GLN A1104
PHE A1059
CYH A 948
PHE A 970
 None
None
None
EDO  A1202 ( 4.5A)
 1.32A 5mwyA-5bp3A:
undetectable		 5mwyA-5bp3A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza C
virus) 		PF00603
(Flu_PA) 		4 GLN A 319
CYH A 551
THR A 523
PHE A 525
 None
 1.25A 5mwyA-5d9aA:
undetectable		 5mwyA-5d9aA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B

(Neotoma lepida) 		PF00067
(p450) 		4 GLN A 172
PHE A 206
CYH A 180
PHE A 188
 None
 1.43A 5mwyA-5e0eA:
2.4		 5mwyA-5e0eA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee4 HPUA

(Kingella
denitrificans) 		PF16960
(HpuA) 		4 GLN A  39
ARG A  37
CYH A 120
THR A  88
 None
 1.34A 5mwyA-5ee4A:
undetectable		 5mwyA-5ee4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giv CARBOXYPEPTIDASE 1

(Deinococcus
radiodurans) 		PF02074
(Peptidase_M32) 		4 GLN A 275
PHE A 225
THR A 233
PHE A 237
 None
 1.44A 5mwyA-5givA:
undetectable		 5mwyA-5givA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j97 CAPRIN-2

(Homo sapiens) 		no annotation 4 PHE A 314
CYH A 262
THR A 261
PHE A 282
 None
 1.43A 5mwyA-5j97A:
undetectable		 5mwyA-5j97A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 ARG A 202
PHE A 203
THR A 260
PHE A 136
 None
 1.40A 5mwyA-5jm7A:
undetectable		 5mwyA-5jm7A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		4 GLN A 525
PHE A 617
THR A 460
PHE A 535
 None
 1.43A 5mwyA-5jrlA:
undetectable		 5mwyA-5jrlA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 6 GLN A 776
ARG A 817
PHE A 829
CYH A 942
THR A 945
PHE A 956
 ECV  A1101 (-2.9A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.9A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 0.27A 5mwyA-5mwpA:
43.2		 5mwyA-5mwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 4 PHE A 835
CYH A 942
THR A 945
PHE A 956
 None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 1.14A 5mwyA-5mwpA:
43.2		 5mwyA-5mwpA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 GLN A  39
ARG A  80
PHE A  92
CYH A 205
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 (-3.5A)
1TA  A 301 (-4.4A)
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 0.32A 5mwyA-5ufsA:
36.9		 5mwyA-5ufsA:
53.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zh5 LYSINE--TRNA LIGASE

(Plasmodium
falciparum) 		no annotation 4 GLN A 367
ARG A 268
PHE A 364
PHE A 373
 None
 1.31A 5mwyA-5zh5A:
undetectable		 5mwyA-5zh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhc PSEUDOPODIUM-ENRICHE
D ATYPICAL KINASE 1

(Homo sapiens) 		no annotation 4 GLN A1664
PHE A1730
CYH A1305
PHE A1706
 None
 1.38A 5mwyA-6bhcA:
undetectable		 5mwyA-6bhcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 4 ARG A 453
PHE A 456
CYH A 467
PHE A 622
 None
 1.48A 5mwyA-6c0tA:
undetectable		 5mwyA-6c0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs NPL4

(Chaetomium
thermophilum) 		no annotation 4 GLN A 341
PHE A 401
THR A 347
PHE A 271
 None
 1.40A 5mwyA-6chsA:
undetectable		 5mwyA-6chsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0x MAD2L1-BINDING
PROTEIN

(Homo sapiens) 		no annotation 4 GLN P 179
PHE P  60
CYH P  74
PHE P 142
 None
 1.08A 5mwyA-6f0xP:
undetectable		 5mwyA-6f0xP:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhf -

(-) 		no annotation 4 ARG A 191
PHE A 187
THR A 207
PHE A 256
 None
 1.45A 5mwyA-6fhfA:
undetectable		 5mwyA-6fhfA:
undetectable