SIMILAR PATTERNS OF AMINO ACIDS FOR 5MWU_A_ACTA601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ouv	CONSERVED HYPOTHETICAL SECRETED PROTEIN (Helicobacter pylori)	PF08238 (Sel1)	4	LYS A 234 ARG A 231 ASP A 201 ASP A 197	None	1.38A	5mwuA-1ouvA: 0.1	5mwuA-1ouvA: 19.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mzb	NICKEL-BINDING PERIPLASMIC PROTEIN (Escherichia coli)	PF00496 (SBP_bac_5)	4	LYS A 52 ARG A 68 ASP A 69 ASP A 70	ACT A 503 (-3.4A) ACT A 503 ( 3.8A) ACT A 503 ( 3.7A) ACT A 503 (-3.0A)	0.17A	5mwuA-3mzbA: 61.1	5mwuA-3mzbA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4qor	CATALASE (Bacillus pumilus)	PF00199 (Catalase) PF06628 (Catalase-rel)	4	LYS A 437 ARG A 473 ASP A 467 ASP A 469	None	1.33A	5mwuA-4qorA: 0.0	5mwuA-4qorA: 23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6cbj	DH270.3 FAB HEAVY CHAIN (Homo sapiens)	no annotation	4	LYS H 63 ARG H 67 ASP H 89 ASP H 90	None	1.48A	5mwuA-6cbjH: 1.6	5mwuA-6cbjH: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6esd	FLAVIN-DEPENDENT L-TRYPTOPHAN OXIDASE VIOA (Chromobacterium violaceum)	no annotation	4	LYS B 297 ARG B 296 ASP B 311 ASP B 144	None	0.71A	5mwuA-6esdB: 0.0	5mwuA-6esdB: undetectable

[["5MWU_A_ACTA601_0","1ouv","Helicobacter pylori","CONSERVED HYPOTHETICAL SECRETED PROTEIN","PF08238(Sel1)",4,"LYS A 234;ARG A 231;ASP A 201;ASP A 197","None","1.38A","5mwuA-1ouvA:0.1","5mwuA-1ouvA:19.37"],["5MWU_A_ACTA601_0","3mzb","Escherichia coli","NICKEL-BINDING PERIPLASMIC PROTEIN","PF00496(SBP_bac_5)",4,"LYS A  52;ARG A  68;ASP A  69;ASP A  70","ACT A 503 (-3.4A);ACT A 503 ( 3.8A);ACT A 503 ( 3.7A);ACT A 503 (-3.0A)","0.17A","5mwuA-3mzbA:61.1","5mwuA-3mzbA:100.00"],["5MWU_A_ACTA601_0","4qor","Bacillus pumilus","CATALASE","PF00199(Catalase);PF06628(Catalase-rel)",4,"LYS A 437;ARG A 473;ASP A 467;ASP A 469","None","1.33A","5mwuA-4qorA:0.0","5mwuA-4qorA:23.36"],["5MWU_A_ACTA601_0","6cbj","Homo sapiens","DH270.3 FAB HEAVY CHAIN","no annotation",4,"LYS H  63;ARG H  67;ASP H  89;ASP H  90","None","1.48A","5mwuA-6cbjH:1.6","5mwuA-6cbjH:undetectable"],["5MWU_A_ACTA601_0","6esd","Chromobacterium violaceum","FLAVIN-DEPENDENT L-TRYPTOPHAN OXIDASE VIOA","no annotation",4,"LYS B 297;ARG B 296;ASP B 311;ASP B 144","None","0.71A","5mwuA-6esdB:0.0","5mwuA-6esdB:undetectable"]]