SIMILAR PATTERNS OF AMINO ACIDS FOR 5MVS_B_ADNB401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1att ANTITHROMBIN III

(Bos taurus) 		PF00079
(Serpin) 		4 GLU A 297
ALA A 294
ASP A  69
ASN A  76
 None
 0.96A 5mvsB-1attA:
undetectable		 5mvsB-1attA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 GLY A 622
GLU A 543
ALA A 539
PHE A 771
 None
 0.91A 5mvsB-1dgjA:
undetectable		 5mvsB-1dgjA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e50 CORE-BINDING FACTOR
CBF-BETA

(Homo sapiens) 		PF02312
(CBF_beta) 		4 GLY B 105
ALA B 132
ASP B   7
PHE B  18
 None
 0.94A 5mvsB-1e50B:
undetectable		 5mvsB-1e50B:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fl2 ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Escherichia
coli) 		PF07992
(Pyr_redox_2) 		4 GLY A 363
GLU A 385
ALA A 387
ASN A 365
 None
 0.92A 5mvsB-1fl2A:
undetectable		 5mvsB-1fl2A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 GLY A 790
ALA A 766
ASP A 854
ASN A 788
 None
 0.98A 5mvsB-1k32A:
undetectable		 5mvsB-1k32A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A 260
ALA A 263
ASP A 303
ASN A 242
 None
None
CA  A 702 (-3.4A)
None
 0.93A 5mvsB-1lrwA:
undetectable		 5mvsB-1lrwA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo0 TRIOSEPHOSPHATE
ISOMERASE

(Caenorhabditis
elegans) 		PF00121
(TIM) 		4 GLY A   8
ASP A  37
PHE A   6
ASN A  10
 None
None
None
ACT  A 906 (-3.8A)
 0.97A 5mvsB-1mo0A:
undetectable		 5mvsB-1mo0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh1 PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 GLY B  72
ASP B 368
PHE B 226
PHE B 101
 None
 0.98A 5mvsB-1qh1B:
3.4		 5mvsB-1qh1B:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyr HIGH LEVEL
KASUGAMYCIN
RESISTANCE PROTEIN

(Escherichia
coli) 		PF00398
(RrnaAD) 		4 GLY A  45
GLU A  66
ASP A  91
ASN A 113
 None
 0.79A 5mvsB-1qyrA:
9.3		 5mvsB-1qyrA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzz ACLACINOMYCIN-10-HYD
ROXYLASE

(Streptomyces
purpurascens) 		PF00891
(Methyltransf_2) 		4 GLY A 190
GLU A 213
ASP A 240
PHE A 241
 SAM  A 635 (-3.8A)
SAM  A 635 (-2.9A)
SAM  A 635 (-3.7A)
SAM  A 635 (-3.4A)
 0.68A 5mvsB-1qzzA:
11.8		 5mvsB-1qzzA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		4 GLY A 266
GLU A 267
ALA A 467
ASN A 262
 None
 0.97A 5mvsB-1t1eA:
undetectable		 5mvsB-1t1eA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2z HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Saccharomyces
cerevisiae) 		PF08123
(DOT1) 		5 GLY A 399
GLU A 422
PHE A 460
ASN A 479
PHE A 483
 SAH  A 801 (-3.1A)
SAH  A 801 (-2.5A)
SAH  A 801 (-3.5A)
SAH  A 801 (-4.4A)
SAH  A 801 ( 4.7A)
 0.28A 5mvsB-1u2zA:
26.1		 5mvsB-1u2zA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A 610
ALA A 649
ASP A 602
PHE A 606
 None
 0.98A 5mvsB-1v7vA:
undetectable		 5mvsB-1v7vA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vho ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		4 GLY A  17
GLU A  68
ALA A 168
ASN A  24
 GLY  A  17 ( 0.0A)
GLU  A  68 ( 0.6A)
ALA  A 168 ( 0.0A)
ASN  A  24 ( 0.6A)
 0.96A 5mvsB-1vhoA:
undetectable		 5mvsB-1vhoA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vra ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ

(Bacillus
halodurans) 		PF01960
(ArgJ) 		4 GLY A  41
ALA A  80
PHE A 154
ASN A  84
 None
 0.97A 5mvsB-1vraA:
undetectable		 5mvsB-1vraA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkm METHIONINE
AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24) 		4 GLU A 280
ALA A 185
PHE A 189
ASN A  53
 MN  A 297 (-2.5A)
MN  A 296 ( 3.9A)
None
MET  A1298 (-3.0A)
 0.84A 5mvsB-1wkmA:
undetectable		 5mvsB-1wkmA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ws6 METHYLTRANSFERASE

(Thermus
thermophilus) 		PF03602
(Cons_hypoth95) 		4 GLY A  70
ALA A 131
PHE A  59
PHE A  46
 None
 0.94A 5mvsB-1ws6A:
12.3		 5mvsB-1ws6A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		4 GLY A  57
GLU A  79
ASP A 105
ASN A 119
 SAH  A1001 (-3.4A)
SAH  A1001 (-2.8A)
SAH  A1001 (-3.2A)
SAH  A1001 (-4.6A)
 0.35A 5mvsB-1wy7A:
11.9		 5mvsB-1wy7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhl SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY MEMBER
(5L265), PUTATIVE
TROPINONE
REDUCTASE-II

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		4 GLY A  37
ALA A  62
ASP A  75
ASN A  39
 NDP  A1278 (-3.8A)
None
None
None
 0.94A 5mvsB-1xhlA:
4.7		 5mvsB-1xhlA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 GLY A 323
GLU A 324
ALA A 489
ASN A 242
 None
GDP  A1002 (-2.6A)
GDP  A1002 (-3.4A)
None
 0.85A 5mvsB-1xjeA:
undetectable		 5mvsB-1xjeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo sapiens) 		PF00398
(RrnaAD) 		4 GLY A  64
GLU A  85
ASP A 113
ASN A 128
 SAM  A4000 (-3.1A)
SAM  A4000 (-2.8A)
SAM  A4000 (-3.8A)
SAM  A4000 (-2.7A)
 0.83A 5mvsB-1zq9A:
11.2		 5mvsB-1zq9A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 GLY B  74
ASP B 372
PHE B 230
PHE B 103
 None
 0.98A 5mvsB-2afhB:
3.8		 5mvsB-2afhB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE

(Sulfurisphaera
tokodaii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLY A 242
ALA A 185
ASP A 178
PHE A 210
 None
 0.98A 5mvsB-2f7lA:
undetectable		 5mvsB-2f7lA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B

(Homo sapiens) 		PF00378
(ECH_1) 		4 LYS A 494
ALA A 495
ASP A 403
ASN A 486
 None
 0.86A 5mvsB-2fbmA:
undetectable		 5mvsB-2fbmA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2

(Homo sapiens) 		PF00378
(ECH_1) 		4 LYS A 214
ALA A 215
ASP A 123
ASN A 206
 None
 0.88A 5mvsB-2fw2A:
undetectable		 5mvsB-2fw2A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtr CHROMODOMAIN Y-LIKE
PROTEIN

(Homo sapiens) 		PF00378
(ECH_1) 		4 LYS A 215
ALA A 216
ASP A 124
ASN A 207
 None
 0.84A 5mvsB-2gtrA:
undetectable		 5mvsB-2gtrA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		4 GLY A 104
ALA A  88
PHE A 304
ASN A 106
 None
 0.96A 5mvsB-2ivpA:
undetectable		 5mvsB-2ivpA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		4 GLY A 314
ASP A 207
PHE A 206
PHE A 374
 None
 0.96A 5mvsB-2o0rA:
3.9		 5mvsB-2o0rA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1w ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 GLY A 151
ALA A 108
ASP A 113
ASN A 129
 None
 0.88A 5mvsB-2o1wA:
undetectable		 5mvsB-2o1wA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		4 GLY A  86
GLU A 121
LYS A 122
ASP A 176
 None
 0.66A 5mvsB-2qy6A:
9.1		 5mvsB-2qy6A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz6 BETA-LACTAMASE

(Pseudomonas
fluorescens) 		PF00144
(Beta-lactamase) 		4 GLY A 156
GLU A 220
ALA A 219
PHE A 121
 None
 0.84A 5mvsB-2qz6A:
undetectable		 5mvsB-2qz6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzp EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF16990
(CBM_35) 		4 GLY A  27
GLU A   9
ALA A   8
ASP A   5
 CA  A1128 ( 4.3A)
CA  A1128 (-2.2A)
None
None
 0.90A 5mvsB-2vzpA:
undetectable		 5mvsB-2vzpA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xka FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		4 GLY A 307
LYS A 285
ALA A 286
PHE A 308
 None
 0.83A 5mvsB-2xkaA:
undetectable		 5mvsB-2xkaA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xok ATP SYNTHASE SUBUNIT
GAMMA, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00231
(ATP-synt) 		4 GLY G 245
GLU G  17
ASP G 238
ASN G 249
 None
 0.95A 5mvsB-2xokG:
2.6		 5mvsB-2xokG:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 GLY A 171
ALA A 206
ASP A 188
ASN A 148
 None
 0.96A 5mvsB-2y05A:
6.4		 5mvsB-2y05A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 GLY O 160
ALA O  98
PHE O 159
ASN O 180
 None
 0.98A 5mvsB-2zf5O:
undetectable		 5mvsB-2zf5O:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		4 GLY A 241
GLU A 262
ASP A 288
ASN A 305
 SAH  A 376 (-3.1A)
SAH  A 376 (-2.7A)
SAH  A 376 (-4.1A)
SAH  A 376 (-4.4A)
 0.53A 5mvsB-2zwvA:
11.4		 5mvsB-2zwvA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs4 UNCHARACTERIZED
PROTEIN PH0321

(Pyrococcus
horikoshii) 		no annotation 4 GLY A  33
GLU A  26
ALA A  29
PHE A 242
 None
 0.89A 5mvsB-3bs4A:
2.7		 5mvsB-3bs4A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chl ALPHA-14 GIARDIN

(Giardia
intestinalis) 		PF00191
(Annexin) 		5 LYS A 308
ALA A 306
ASP A 292
PHE A 291
PHE A 255
 None
 1.47A 5mvsB-3chlA:
undetectable		 5mvsB-3chlA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 GLY A-183
LYS A-160
ALA A-159
ASP A-165
 None
 0.85A 5mvsB-3ehsA:
undetectable		 5mvsB-3ehsA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2

(Homo sapiens) 		PF01852
(START) 		4 GLY A 531
ALA A 492
PHE A 532
ASN A 548
 None
None
None
GOL  A 595 (-4.0A)
 0.88A 5mvsB-3fo5A:
undetectable		 5mvsB-3fo5A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		4 GLY A  38
GLU A  59
ASP A  84
ASN A 101
 None
 0.73A 5mvsB-3fydA:
10.6		 5mvsB-3fydA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis) 		no annotation 4 GLY L 144
ALA L  76
ASP S 359
ASN L 142
 None
 0.96A 5mvsB-3g9kL:
undetectable		 5mvsB-3g9kL:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gry DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		4 GLY A  38
GLU A  59
ASP A  84
ASN A 101
 SAM  A 300 (-3.3A)
SAM  A 300 (-2.8A)
SAM  A 300 (-3.7A)
SAM  A 300 (-3.6A)
 0.62A 5mvsB-3gryA:
11.9		 5mvsB-3gryA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		4 GLY A 190
GLU A 213
ASP A 240
PHE A 241
 SAH  A 350 (-4.1A)
SAH  A 350 (-2.9A)
SAH  A 350 (-3.4A)
SAH  A 350 (-3.6A)
 0.69A 5mvsB-3gxoA:
11.0		 5mvsB-3gxoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hst PROTEIN
RV2228C/MT2287

(Mycobacterium
tuberculosis) 		PF13456
(RVT_3) 		4 GLY B  10
GLU B  49
ASP B 123
ASN B  14
 None
 0.96A 5mvsB-3hstB:
undetectable		 5mvsB-3hstB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE

(Ruegeria
pomeroyi) 		PF12692
(Methyltransf_17) 		4 GLY A  47
GLU A  70
ALA A  72
ASP A  90
 SAM  A 200 (-3.3A)
SAM  A 200 (-2.7A)
None
SAM  A 200 (-3.2A)
 0.73A 5mvsB-3ihtA:
9.3		 5mvsB-3ihtA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE

(Coxiella
burnetii) 		PF00883
(Peptidase_M17) 		4 ASP A  76
PHE A  77
ASN A  92
PHE A  96
 None
 0.97A 5mvsB-3ij3A:
undetectable		 5mvsB-3ij3A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Cytophaga
hutchinsonii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 GLY A  49
GLU A 224
ALA A 225
PHE A  56
 None
 0.80A 5mvsB-3ilvA:
undetectable		 5mvsB-3ilvA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS

(Vibrio
parahaemolyticus) 		PF02661
(Fic) 		4 GLY A 152
LYS A 156
ALA A 157
ASP A 161
 None
 0.95A 5mvsB-3letA:
undetectable		 5mvsB-3letA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		4 ASP A 636
PHE A 638
ASN A 682
PHE A 686
 None
 0.96A 5mvsB-3m62A:
undetectable		 5mvsB-3m62A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0y LIPOPROTEIN

(Colwellia
psychrerythraea) 		PF05960
(DUF885) 		4 GLY A 431
ALA A 500
PHE A 430
ASN A 427
 None
 0.90A 5mvsB-3o0yA:
undetectable		 5mvsB-3o0yA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o53 PROTEIN LRIM1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 GLU A 252
LYS A 253
ALA A 254
ASP A 278
 None
 0.71A 5mvsB-3o53A:
undetectable		 5mvsB-3o53A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1

(Anopheles
gambiae) 		PF00560
(LRR_1) 		4 GLU A 252
LYS A 253
ALA A 254
ASP A 278
 None
 0.74A 5mvsB-3ojaA:
undetectable		 5mvsB-3ojaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 GLY A 166
LYS A 437
ALA A 438
ASP A 432
 None
 0.95A 5mvsB-3osqA:
undetectable		 5mvsB-3osqA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		4 GLY A  82
ALA A 111
ASP A 116
PHE A 119
 None
 0.94A 5mvsB-3pkoA:
undetectable		 5mvsB-3pkoA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLY A  66
GLU A 101
LYS A 102
ASP A 156
 SAM  A 670 (-3.5A)
SAM  A 670 (-2.6A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
 0.58A 5mvsB-3ps9A:
8.6		 5mvsB-3ps9A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLY A  66
GLU A 101
LYS A 102
ASP A 156
 None
 0.61A 5mvsB-3pvcA:
8.3		 5mvsB-3pvcA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rha PUTRESCINE OXIDASE

(Paenarthrobacter
aurescens) 		PF01593
(Amino_oxidase) 		4 GLY A 168
ALA A 163
PHE A 150
PHE A 198
 None
 0.88A 5mvsB-3rhaA:
undetectable		 5mvsB-3rhaA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgi DNA LIGASE

(Mycobacterium
tuberculosis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB) 		4 GLY A 399
ALA A 205
ASN A 209
PHE A 192
 None
 0.90A 5mvsB-3sgiA:
undetectable		 5mvsB-3sgiA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Mus musculus) 		PF04389
(Peptidase_M28) 		4 GLY A 252
ALA A 162
ASP A 249
ASN A 339
 None
 0.95A 5mvsB-3si1A:
undetectable		 5mvsB-3si1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 GLU A 248
LYS A 249
ASP A 276
ASN A 293
 SFG  A 401 (-2.6A)
SFG  A 401 (-4.9A)
SFG  A 401 (-3.4A)
SFG  A 401 (-4.4A)
 0.57A 5mvsB-3tm5A:
12.5		 5mvsB-3tm5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9l 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		4 GLY A 224
LYS A 229
ALA A 230
ASN A 220
 None
 0.91A 5mvsB-3u9lA:
5.4		 5mvsB-3u9lA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukf UDP-GALACTOPYRANOSE
MUTASE

(Aspergillus
fumigatus) 		PF13450
(NAD_binding_8) 		4 GLY A 217
ALA A  47
PHE A 212
PHE A 331
 None
FDA  A 600 ( 4.3A)
None
None
 0.94A 5mvsB-3ukfA:
undetectable		 5mvsB-3ukfA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		4 GLY A  46
GLU A  71
ASP A  94
ASN A 117
 None
 0.81A 5mvsB-3uzuA:
10.2		 5mvsB-3uzuA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		4 GLY A 104
GLU A 133
LYS A 134
ASP A 174
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
 0.67A 5mvsB-3vywA:
8.5		 5mvsB-3vywA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 ALA A 682
ASP A 630
ASN A 687
PHE A 388
 None
RAM  A1202 (-3.4A)
RAM  A1206 (-3.1A)
None
 0.99A 5mvsB-3w5nA:
2.6		 5mvsB-3w5nA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF13360
(PQQ_2) 		4 GLY A 254
ALA A 257
ASP A 297
ASN A 236
 None
None
CA  A 702 (-3.6A)
None
 0.97A 5mvsB-4aahA:
undetectable		 5mvsB-4aahA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora) 		PF02435
(Glyco_hydro_68) 		4 GLY A 380
ALA A  71
ASP A  46
PHE A 365
 None
None
FRU  A1415 (-2.9A)
None
 0.98A 5mvsB-4d47A:
undetectable		 5mvsB-4d47A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		4 GLY A  85
GLU A 109
ALA A 111
ASP A 134
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.3A)
 0.38A 5mvsB-4df3A:
9.9		 5mvsB-4df3A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 303
ALA A 308
PHE A 336
PHE A  27
 None
 0.96A 5mvsB-4dwdA:
undetectable		 5mvsB-4dwdA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzh AMIDOHYDROLASE

(Xanthomonas
campestris) 		PF01979
(Amidohydro_1) 		4 GLY A 119
ALA A 437
PHE A 115
ASN A  81
 None
 0.75A 5mvsB-4dzhA:
2.1		 5mvsB-4dzhA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1j GLYCEROL KINASE

(Sinorhizobium
meliloti) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 GLY A 185
ALA A 122
PHE A 184
ASN A 207
 None
 0.98A 5mvsB-4e1jA:
undetectable		 5mvsB-4e1jA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Burkholderia
ambifaria) 		PF02222
(ATP-grasp) 		4 GLY A  18
ALA A  15
ASP A  56
PHE A  29
 None
 0.88A 5mvsB-4e4tA:
2.8		 5mvsB-4e4tA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4er6 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		7 GLY A 163
GLU A 186
ALA A 188
ASP A 222
PHE A 223
ASN A 241
PHE A 245
 AW2  A 502 (-3.2A)
AW2  A 502 (-2.6A)
AW2  A 502 (-3.6A)
AW2  A 502 (-3.5A)
AW2  A 502 (-3.4A)
AW2  A 502 (-4.3A)
AW2  A 502 (-4.3A)
 0.44A 5mvsB-4er6A:
41.6		 5mvsB-4er6A:
80.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL

(Mus musculus) 		PF00398
(RrnaAD) 		5 GLY A  63
GLU A  85
LYS A  86
ASP A 111
ASN A 141
 ACT  A 402 (-3.4A)
ACT  A 402 (-2.9A)
None
None
None
 0.38A 5mvsB-4gc5A:
9.7		 5mvsB-4gc5A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gps KLLA0E02245P

(Kluyveromyces
lactis) 		no annotation 5 GLY A 309
LYS A 322
ALA A 323
PHE A 310
PHE A 280
 None
 1.44A 5mvsB-4gpsA:
undetectable		 5mvsB-4gpsA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		4 GLY A 460
ALA A 182
PHE A 144
PHE A 419
 None
 0.88A 5mvsB-4issA:
undetectable		 5mvsB-4issA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		4 GLY A  12
ALA A  40
ASP A  70
ASN A  17
 None
 0.93A 5mvsB-4iwhA:
undetectable		 5mvsB-4iwhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Burkholderia
thailandensis) 		PF02222
(ATP-grasp) 		4 GLY A  18
ALA A  15
ASP A  56
PHE A  29
 None
 0.87A 5mvsB-4izoA:
4.3		 5mvsB-4izoA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Brugia malayi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LYS A 167
ALA A 163
ASP A 171
ASN A 230
 None
 0.98A 5mvsB-4k9dA:
3.5		 5mvsB-4k9dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		4 GLY A  73
ALA A 104
ASP A 109
PHE A 112
 None
 0.82A 5mvsB-4lfeA:
undetectable		 5mvsB-4lfeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis) 		PF02222
(ATP-grasp) 		4 GLY A   7
LYS A  31
ASP A  45
ASN A  68
 None
 0.94A 5mvsB-4ma5A:
4.2		 5mvsB-4ma5A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe6 PUTATIVE ABC
TRANSPORTER

(Thermobispora
bispora) 		PF13407
(Peripla_BP_4) 		4 GLY A 219
GLU A 265
ALA A 270
ASP A 335
 None
 0.95A 5mvsB-4pe6A:
2.2		 5mvsB-4pe6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe6 PUTATIVE ABC
TRANSPORTER

(Thermobispora
bispora) 		PF13407
(Peripla_BP_4) 		4 GLY A 219
LYS A 224
ALA A 225
ASN A  59
 None
None
None
LTH  A 401 (-3.2A)
 0.88A 5mvsB-4pe6A:
2.2		 5mvsB-4pe6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		4 GLY A 468
LYS A 470
ALA A 471
ASP A 447
 None
 0.91A 5mvsB-4pxnA:
5.6		 5mvsB-4pxnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		4 GLY A 208
LYS A 173
ALA A 169
ASP A 174
 None
 0.75A 5mvsB-4qfuA:
undetectable		 5mvsB-4qfuA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE

(Agrobacterium
tumefaciens) 		PF00701
(DHDPS) 		4 GLU A 196
ALA A 195
PHE A 248
ASN A 216
 None
 0.78A 5mvsB-4ur8A:
undetectable		 5mvsB-4ur8A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C

(Acinetobacter
baumannii;
Escherichia
coli) 		PF00114
(Pilin)
PF13416
(SBP_bac_8) 		4 GLY A 166
LYS A 189
ALA A 190
ASP A 184
 None
 0.99A 5mvsB-4xa2A:
undetectable		 5mvsB-4xa2A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf7 CARBOHYDRATE/PYRIMID
INE KINASE, PFKB
FAMILY

(Thermococcus
kodakarensis) 		no annotation 4 GLY A   7
GLU A 115
ALA A 113
ASP A 134
 None
None
None
MG  A 303 ( 4.0A)
 0.97A 5mvsB-4xf7A:
2.7		 5mvsB-4xf7A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgk UDP-GALACTOPYRANOSE
MUTASE

(Corynebacterium
diphtheriae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 GLY A  10
GLU A  34
LYS A  35
ASP A 220
 FDA  A 403 (-3.1A)
FDA  A 403 (-2.7A)
None
FDA  A 403 (-3.7A)
 0.43A 5mvsB-4xgkA:
undetectable		 5mvsB-4xgkA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvg ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Escherichia
coli) 		PF07992
(Pyr_redox_2)
PF13192
(Thioredoxin_3) 		4 GLY A 363
GLU A 385
ALA A 387
ASN A 365
 None
 0.96A 5mvsB-4xvgA:
undetectable		 5mvsB-4xvgA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ALA B 304
ASP B 348
PHE B 349
PHE C 254
 None
 0.97A 5mvsB-5a8rB:
undetectable		 5mvsB-5a8rB:
22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		8 GLY A 163
GLU A 186
LYS A 187
ALA A 188
ASP A 222
PHE A 223
ASN A 241
PHE A 245
 None
None
None
None
None
None
5F7  A 401 (-3.6A)
None
 0.27A 5mvsB-5dtrA:
46.9		 5mvsB-5dtrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evl BETA-LACTAMASE

(Chromobacterium
violaceum) 		PF00144
(Beta-lactamase) 		4 GLY A 157
GLU A 221
ALA A 220
PHE A 122
 None
SO4  A 401 (-2.9A)
None
None
 0.95A 5mvsB-5evlA:
undetectable		 5mvsB-5evlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3

(Rattus
norvegicus) 		PF12796
(Ank_2)
PF16511
(FERM_f0) 		4 GLY A  54
GLU A  70
PHE A  90
ASN A  52
 None
EDO  A1377 ( 4.4A)
None
None
 0.95A 5mvsB-5g4xA:
undetectable		 5mvsB-5g4xA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		4 GLY A 293
GLU A1323
ALA A1324
ASP A 615
 None
 0.83A 5mvsB-5gjvA:
2.0		 5mvsB-5gjvA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 GLY A 172
LYS A 149
ALA A 148
ASN A 170
 None
 0.89A 5mvsB-5hctA:
undetectable		 5mvsB-5hctA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A 460
ALA A 182
PHE A 144
PHE A 419
 None
 0.90A 5mvsB-5i8iA:
undetectable		 5mvsB-5i8iA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius) 		PF00891
(Methyltransf_2) 		4 GLY A 187
GLU A 210
ASP A 237
PHE A 238
 SAH  A 401 (-3.9A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.7A)
SAH  A 401 (-3.4A)
 0.70A 5mvsB-5jr3A:
11.1		 5mvsB-5jr3A:
24.80