SIMILAR PATTERNS OF AMINO ACIDS FOR 5MVS_A_ADNA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1att ANTITHROMBIN III

(Bos taurus) 		PF00079
(Serpin) 		4 GLU A 297
ALA A 294
ASP A  69
ASN A  76
 None
 0.98A 5mvsA-1attA:
undetectable		 5mvsA-1attA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 GLY A 622
GLU A 543
ALA A 539
PHE A 771
 None
 0.88A 5mvsA-1dgjA:
undetectable		 5mvsA-1dgjA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fl2 ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Escherichia
coli) 		PF07992
(Pyr_redox_2) 		4 GLY A 363
GLU A 385
ALA A 387
ASN A 365
 None
 0.94A 5mvsA-1fl2A:
undetectable		 5mvsA-1fl2A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 GLY A 251
GLU A 623
ALA A 630
ASP A 664
 None
 0.96A 5mvsA-1g0dA:
undetectable		 5mvsA-1g0dA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8t UDP-GALACTOPYRANOSE
MUTASE

(Escherichia
coli) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 GLY A   8
GLU A  31
LYS A  32
ASP A 212
 FAD  A 450 (-3.2A)
FAD  A 450 (-2.8A)
FAD  A 450 (-3.8A)
FAD  A 450 (-3.5A)
 0.59A 5mvsA-1i8tA:
3.0		 5mvsA-1i8tA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 GLY A 790
ALA A 766
ASP A 854
ASN A 788
 None
 1.01A 5mvsA-1k32A:
2.4		 5mvsA-1k32A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A 260
ALA A 263
ASP A 303
ASN A 242
 None
None
CA  A 702 (-3.4A)
None
 1.00A 5mvsA-1lrwA:
undetectable		 5mvsA-1lrwA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo0 TRIOSEPHOSPHATE
ISOMERASE

(Caenorhabditis
elegans) 		PF00121
(TIM) 		4 GLY A   8
ASP A  37
PHE A   6
ASN A  10
 None
None
None
ACT  A 906 (-3.8A)
 0.97A 5mvsA-1mo0A:
undetectable		 5mvsA-1mo0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		4 GLY A 108
GLU A 132
LYS A 133
ASP A 160
 None
 0.74A 5mvsA-1o54A:
13.1		 5mvsA-1o54A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyr HIGH LEVEL
KASUGAMYCIN
RESISTANCE PROTEIN

(Escherichia
coli) 		PF00398
(RrnaAD) 		4 GLY A  45
GLU A  66
ASP A  91
ASN A 113
 None
 0.80A 5mvsA-1qyrA:
2.9		 5mvsA-1qyrA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzz ACLACINOMYCIN-10-HYD
ROXYLASE

(Streptomyces
purpurascens) 		PF00891
(Methyltransf_2) 		4 GLY A 190
GLU A 213
ASP A 240
PHE A 241
 SAM  A 635 (-3.8A)
SAM  A 635 (-2.9A)
SAM  A 635 (-3.7A)
SAM  A 635 (-3.4A)
 0.64A 5mvsA-1qzzA:
11.7		 5mvsA-1qzzA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		4 GLY A 266
GLU A 267
ALA A 467
ASN A 262
 None
 0.96A 5mvsA-1t1eA:
undetectable		 5mvsA-1t1eA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT

(Salmonella
enterica) 		PF01791
(DeoC) 		4 GLY A 153
LYS A 121
ALA A 120
ASP A   8
 None
 0.87A 5mvsA-1to3A:
undetectable		 5mvsA-1to3A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2z HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Saccharomyces
cerevisiae) 		PF08123
(DOT1) 		4 GLY A 399
GLU A 422
PHE A 460
ASN A 479
 SAH  A 801 (-3.1A)
SAH  A 801 (-2.5A)
SAH  A 801 (-3.5A)
SAH  A 801 (-4.4A)
 0.24A 5mvsA-1u2zA:
26.1		 5mvsA-1u2zA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urd MALTOSE-BINDING
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF01547
(SBP_bac_1) 		4 GLY A 235
LYS A 239
ALA A 240
ASP A 256
 None
 0.95A 5mvsA-1urdA:
undetectable		 5mvsA-1urdA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A 610
ALA A 649
ASP A 602
PHE A 606
 None
 1.00A 5mvsA-1v7vA:
2.1		 5mvsA-1v7vA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vho ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		4 GLY A  17
GLU A  68
ALA A 168
ASN A  24
 GLY  A  17 ( 0.0A)
GLU  A  68 ( 0.6A)
ALA  A 168 ( 0.0A)
ASN  A  24 ( 0.6A)
 0.97A 5mvsA-1vhoA:
undetectable		 5mvsA-1vhoA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vra ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ

(Bacillus
halodurans) 		PF01960
(ArgJ) 		4 GLY A  41
ALA A  80
PHE A 154
ASN A  84
 None
 0.98A 5mvsA-1vraA:
undetectable		 5mvsA-1vraA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vsg VARIANT SURFACE
GLYCOPROTEIN MITAT
1.2

(Trypanosoma
brucei) 		PF00913
(Trypan_glycop) 		5 GLY A 197
GLU A   3
LYS A   4
ALA A   2
ASN A 194
 None
 1.45A 5mvsA-1vsgA:
undetectable		 5mvsA-1vsgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		4 GLY A 507
ALA A 160
ASP A 135
PHE A 497
 None
 0.88A 5mvsA-1w18A:
undetectable		 5mvsA-1w18A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkm METHIONINE
AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24) 		4 GLU A 280
ALA A 185
PHE A 189
ASN A  53
 MN  A 297 (-2.5A)
MN  A 296 ( 3.9A)
None
MET  A1298 (-3.0A)
 0.83A 5mvsA-1wkmA:
undetectable		 5mvsA-1wkmA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		4 GLY A  57
GLU A  79
ASP A 105
ASN A 119
 SAH  A1001 (-3.4A)
SAH  A1001 (-2.8A)
SAH  A1001 (-3.2A)
SAH  A1001 (-4.6A)
 0.39A 5mvsA-1wy7A:
8.1		 5mvsA-1wy7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhl SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY MEMBER
(5L265), PUTATIVE
TROPINONE
REDUCTASE-II

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		4 GLY A  37
ALA A  62
ASP A  75
ASN A  39
 NDP  A1278 (-3.8A)
None
None
None
 0.89A 5mvsA-1xhlA:
4.7		 5mvsA-1xhlA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 GLY A 323
GLU A 324
ALA A 489
ASN A 242
 None
GDP  A1002 (-2.6A)
GDP  A1002 (-3.4A)
None
 0.87A 5mvsA-1xjeA:
undetectable		 5mvsA-1xjeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo sapiens) 		PF00398
(RrnaAD) 		4 GLY A  64
GLU A  85
ASP A 113
ASN A 128
 SAM  A4000 (-3.1A)
SAM  A4000 (-2.8A)
SAM  A4000 (-3.8A)
SAM  A4000 (-2.7A)
 0.86A 5mvsA-1zq9A:
11.2		 5mvsA-1zq9A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 GLY A  29
GLU A  56
LYS A  57
ALA A  58
 FAD  A1000 (-3.3A)
FAD  A1000 (-2.7A)
FAD  A1000 (-4.0A)
FAD  A1000 ( 4.6A)
 0.65A 5mvsA-2fjaA:
undetectable		 5mvsA-2fjaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 GLY A  30
GLU A  56
LYS A  57
ALA A  58
 FAD  A1000 (-4.3A)
FAD  A1000 (-2.7A)
FAD  A1000 (-4.0A)
FAD  A1000 ( 4.6A)
 0.99A 5mvsA-2fjaA:
undetectable		 5mvsA-2fjaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Streptococcus
mutans) 		PF00694
(Aconitase_C) 		4 GLY A  75
LYS A 124
ASP A 128
ASN A  18
 None
 0.96A 5mvsA-2hcuA:
undetectable		 5mvsA-2hcuA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Streptococcus
mutans) 		PF00694
(Aconitase_C) 		4 GLY A 102
LYS A 124
ASP A 128
ASN A  77
 None
 0.99A 5mvsA-2hcuA:
undetectable		 5mvsA-2hcuA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		4 GLY A 104
ALA A  88
PHE A 304
ASN A 106
 None
 0.96A 5mvsA-2ivpA:
undetectable		 5mvsA-2ivpA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvn HYPOTHETICAL PROTEIN

(Synechococcus
elongatus) 		PF08848
(DUF1818) 		4 GLY A  82
ALA A 105
ASP A  85
PHE A  83
 None
 1.00A 5mvsA-2nvnA:
undetectable		 5mvsA-2nvnA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1w ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 GLY A 151
ALA A 108
ASP A 113
ASN A 129
 None
 0.89A 5mvsA-2o1wA:
undetectable		 5mvsA-2o1wA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		4 GLY A 152
GLU A 148
LYS A 110
ALA A 113
 None
 0.96A 5mvsA-2pi5A:
undetectable		 5mvsA-2pi5A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		4 GLY A 241
LYS A 183
ALA A 182
ASN A  55
 None
GDP  A 362 (-3.9A)
None
None
 0.88A 5mvsA-2qagA:
undetectable		 5mvsA-2qagA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe7 ATP SYNTHASE SUBUNIT
BETA

(Bacillus sp.
TA2.A1) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 GLY D  94
GLU D  95
ASP D  98
PHE D  90
 None
 0.97A 5mvsA-2qe7D:
undetectable		 5mvsA-2qe7D:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnr SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		4 GLY A 241
LYS A 183
ALA A 182
ASN A  55
 GDP  A1401 (-3.9A)
GDP  A1401 (-3.2A)
None
None
 0.85A 5mvsA-2qnrA:
undetectable		 5mvsA-2qnrA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzp EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF16990
(CBM_35) 		4 GLY A  27
GLU A   9
ALA A   8
ASP A   5
 CA  A1128 ( 4.3A)
CA  A1128 (-2.2A)
None
None
 0.92A 5mvsA-2vzpA:
undetectable		 5mvsA-2vzpA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvn ASPERGILLUS
FUMIGATUS CHITINASE
A1

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		4 GLY A 283
ALA A 239
ASP A 244
ASN A 281
 None
 0.99A 5mvsA-2xvnA:
undetectable		 5mvsA-2xvnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 GLY A 171
ALA A 206
ASP A 188
ASN A 148
 None
 0.97A 5mvsA-2y05A:
6.6		 5mvsA-2y05A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 GLY O 160
ALA O  98
PHE O 159
ASN O 180
 None
 0.99A 5mvsA-2zf5O:
undetectable		 5mvsA-2zf5O:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		4 GLY A 241
GLU A 262
ASP A 288
ASN A 305
 SAH  A 376 (-3.1A)
SAH  A 376 (-2.7A)
SAH  A 376 (-4.1A)
SAH  A 376 (-4.4A)
 0.51A 5mvsA-2zwvA:
12.2		 5mvsA-2zwvA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2

(Homo sapiens) 		PF01852
(START) 		4 GLY A 531
ALA A 492
PHE A 532
ASN A 548
 None
None
None
GOL  A 595 (-4.0A)
 0.89A 5mvsA-3fo5A:
undetectable		 5mvsA-3fo5A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE

(Thermus
thermophilus) 		PF00398
(RrnaAD) 		4 GLY A  54
GLU A  75
LYS A  76
ASP A  99
 None
 0.85A 5mvsA-3futA:
10.9		 5mvsA-3futA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		4 GLY A  38
GLU A  59
ASP A  84
ASN A 101
 None
 0.74A 5mvsA-3fydA:
3.3		 5mvsA-3fydA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis) 		no annotation 4 GLY L 144
ALA L  76
ASP S 359
ASN L 142
 None
 0.96A 5mvsA-3g9kL:
undetectable		 5mvsA-3g9kL:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gry DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		4 GLY A  38
GLU A  59
ASP A  84
ASN A 101
 SAM  A 300 (-3.3A)
SAM  A 300 (-2.8A)
SAM  A 300 (-3.7A)
SAM  A 300 (-3.6A)
 0.63A 5mvsA-3gryA:
3.7		 5mvsA-3gryA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		4 GLY A 190
GLU A 213
ASP A 240
PHE A 241
 SAH  A 350 (-4.1A)
SAH  A 350 (-2.9A)
SAH  A 350 (-3.4A)
SAH  A 350 (-3.6A)
 0.65A 5mvsA-3gxoA:
2.4		 5mvsA-3gxoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hst PROTEIN
RV2228C/MT2287

(Mycobacterium
tuberculosis) 		PF13456
(RVT_3) 		4 GLY B  10
GLU B  49
ASP B 123
ASN B  14
 None
 0.98A 5mvsA-3hstB:
undetectable		 5mvsA-3hstB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE

(Ruegeria
pomeroyi) 		PF12692
(Methyltransf_17) 		4 GLY A  47
GLU A  70
ALA A  72
ASP A  90
 SAM  A 200 (-3.3A)
SAM  A 200 (-2.7A)
None
SAM  A 200 (-3.2A)
 0.74A 5mvsA-3ihtA:
9.3		 5mvsA-3ihtA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF01823
(MACPF) 		4 GLY A 316
ALA A 239
ASP A  88
PHE A  89
 None
 1.01A 5mvsA-3kk7A:
undetectable		 5mvsA-3kk7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS

(Vibrio
parahaemolyticus) 		PF02661
(Fic) 		4 GLY A 152
LYS A 156
ALA A 157
ASP A 161
 None
 0.91A 5mvsA-3letA:
2.0		 5mvsA-3letA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0y LIPOPROTEIN

(Colwellia
psychrerythraea) 		PF05960
(DUF885) 		4 GLY A 431
ALA A 500
PHE A 430
ASN A 427
 None
 0.90A 5mvsA-3o0yA:
undetectable		 5mvsA-3o0yA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o53 PROTEIN LRIM1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 GLU A 252
LYS A 253
ALA A 254
ASP A 278
 None
 0.44A 5mvsA-3o53A:
undetectable		 5mvsA-3o53A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1

(Anopheles
gambiae) 		PF00560
(LRR_1) 		4 GLU A 252
LYS A 253
ALA A 254
ASP A 278
 None
 0.42A 5mvsA-3ojaA:
2.2		 5mvsA-3ojaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		4 GLY A  82
ALA A 111
ASP A 116
PHE A 119
 None
 0.99A 5mvsA-3pkoA:
undetectable		 5mvsA-3pkoA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Aquifex
aeolicus) 		PF00398
(RrnaAD) 		4 GLY B  38
GLU B  60
ASP B  83
ASN B 101
 None
 1.01A 5mvsA-3r9xB:
10.4		 5mvsA-3r9xB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Mus musculus) 		PF04389
(Peptidase_M28) 		4 GLY A 252
ALA A 162
ASP A 249
ASN A 339
 None
 0.96A 5mvsA-3si1A:
undetectable		 5mvsA-3si1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		4 GLY A  46
GLU A  71
ASP A  94
ASN A 117
 None
 0.85A 5mvsA-3uzuA:
10.5		 5mvsA-3uzuA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLY A1603
ALA A1728
ASP A1559
PHE A1556
ASN A1318
 None
 1.42A 5mvsA-3va7A:
2.6		 5mvsA-3va7A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		4 GLY A 104
GLU A 133
LYS A 134
ASP A 174
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
 0.58A 5mvsA-3vywA:
2.6		 5mvsA-3vywA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4u BIFUNCTIONAL PROTEIN
FOLD

(Acinetobacter
baumannii) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 GLU A  15
LYS A  12
ALA A  11
ASN A  55
 None
 0.98A 5mvsA-4b4uA:
4.6		 5mvsA-4b4uA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora) 		PF02435
(Glyco_hydro_68) 		4 GLY A 380
ALA A  71
ASP A  46
PHE A 365
 None
None
FRU  A1415 (-2.9A)
None
 0.98A 5mvsA-4d47A:
undetectable		 5mvsA-4d47A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		4 GLY A  85
GLU A 109
ALA A 111
ASP A 134
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.3A)
 0.43A 5mvsA-4df3A:
9.9		 5mvsA-4df3A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzh AMIDOHYDROLASE

(Xanthomonas
campestris) 		PF01979
(Amidohydro_1) 		4 GLY A 119
ALA A 437
PHE A 115
ASN A  81
 None
 0.76A 5mvsA-4dzhA:
undetectable		 5mvsA-4dzhA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1j GLYCEROL KINASE

(Sinorhizobium
meliloti) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 GLY A 185
ALA A 122
PHE A 184
ASN A 207
 None
 0.99A 5mvsA-4e1jA:
undetectable		 5mvsA-4e1jA:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4er6 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		6 GLY A 163
GLU A 186
ALA A 188
ASP A 222
PHE A 223
ASN A 241
 AW2  A 502 (-3.2A)
AW2  A 502 (-2.6A)
AW2  A 502 (-3.6A)
AW2  A 502 (-3.5A)
AW2  A 502 (-3.4A)
AW2  A 502 (-4.3A)
 0.50A 5mvsA-4er6A:
41.6		 5mvsA-4er6A:
80.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL

(Mus musculus) 		PF00398
(RrnaAD) 		5 GLY A  63
GLU A  85
LYS A  86
ASP A 111
ASN A 141
 ACT  A 402 (-3.4A)
ACT  A 402 (-2.9A)
None
None
None
 0.68A 5mvsA-4gc5A:
9.6		 5mvsA-4gc5A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		4 GLY A  12
ALA A  40
ASP A  70
ASN A  17
 None
 0.92A 5mvsA-4iwhA:
undetectable		 5mvsA-4iwhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		4 GLY A  73
ALA A 104
ASP A 109
PHE A 112
 None
 0.86A 5mvsA-4lfeA:
undetectable		 5mvsA-4lfeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis) 		PF02222
(ATP-grasp) 		4 GLY A   7
LYS A  31
ASP A  45
ASN A  68
 None
 0.93A 5mvsA-4ma5A:
4.2		 5mvsA-4ma5A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohq TRIOSEPHOSPHATE
ISOMERASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00121
(TIM) 		4 GLY A  10
ASP A  39
PHE A   8
ASN A  12
 None
 1.00A 5mvsA-4ohqA:
undetectable		 5mvsA-4ohqA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovd PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 GLY A 170
ALA A  81
ASP A  74
ASN A 168
 None
 1.01A 5mvsA-4ovdA:
undetectable		 5mvsA-4ovdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe6 PUTATIVE ABC
TRANSPORTER

(Thermobispora
bispora) 		PF13407
(Peripla_BP_4) 		4 GLY A 219
GLU A 265
ALA A 270
ASP A 335
 None
 0.96A 5mvsA-4pe6A:
2.4		 5mvsA-4pe6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		4 GLY A 208
LYS A 173
ALA A 169
ASP A 174
 None
 0.86A 5mvsA-4qfuA:
undetectable		 5mvsA-4qfuA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhr ALANINE RACEMASE

(Acinetobacter
baumannii) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 GLY A 324
GLU A 321
ALA A 288
ASP A 331
 None
 0.97A 5mvsA-4qhrA:
undetectable		 5mvsA-4qhrA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxt SUGAR ABC
TRANSPORTER

(Agrobacterium
tumefaciens) 		PF13407
(Peripla_BP_4) 		4 GLY A 173
GLU A 102
LYS A 104
ALA A 105
 None
 0.95A 5mvsA-4rxtA:
undetectable		 5mvsA-4rxtA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 301
LYS A 380
ASP A 285
ASN A 303
 None
 1.01A 5mvsA-4udrA:
2.1		 5mvsA-4udrA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE

(Agrobacterium
tumefaciens) 		PF00701
(DHDPS) 		4 GLU A 196
ALA A 195
PHE A 248
ASN A 216
 None
 0.76A 5mvsA-4ur8A:
undetectable		 5mvsA-4ur8A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C) 		4 GLY A 450
LYS A 454
ALA A 455
ASN A 510
 None
 0.97A 5mvsA-4uwqA:
undetectable		 5mvsA-4uwqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnx NETRIN-4

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		4 GLY A 418
LYS A 393
ALA A 394
ASP A 381
 None
 1.01A 5mvsA-4wnxA:
undetectable		 5mvsA-4wnxA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdy KETOL-ACID
REDUCTOISOMERASE

(uncultured
archaeon
GZfos26G2) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 GLY A 113
GLU A 191
ALA A 133
PHE A 188
ASN A 115
 None
 1.40A 5mvsA-4xdyA:
3.7		 5mvsA-4xdyA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf7 CARBOHYDRATE/PYRIMID
INE KINASE, PFKB
FAMILY

(Thermococcus
kodakarensis) 		no annotation 4 GLY A   7
GLU A 115
ALA A 113
ASP A 134
 None
None
None
MG  A 303 ( 4.0A)
 0.97A 5mvsA-4xf7A:
2.7		 5mvsA-4xf7A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgk UDP-GALACTOPYRANOSE
MUTASE

(Corynebacterium
diphtheriae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 GLY A  10
GLU A  34
LYS A  35
ASP A 220
 FDA  A 403 (-3.1A)
FDA  A 403 (-2.7A)
None
FDA  A 403 (-3.7A)
 0.51A 5mvsA-4xgkA:
undetectable		 5mvsA-4xgkA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvg ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Escherichia
coli) 		PF07992
(Pyr_redox_2)
PF13192
(Thioredoxin_3) 		4 GLY A 363
GLU A 385
ALA A 387
ASN A 365
 None
 0.98A 5mvsA-4xvgA:
2.3		 5mvsA-4xvgA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0m OXYR

(Pseudomonas
aeruginosa) 		PF03466
(LysR_substrate) 		4 GLY A  96
LYS A  94
ASP A 142
ASN A 127
 None
 1.01A 5mvsA-4y0mA:
undetectable		 5mvsA-4y0mA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4w PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 GLY A 270
GLU A 273
LYS A 311
ALA A 313
 None
 0.91A 5mvsA-5d4wA:
undetectable		 5mvsA-5d4wA:
15.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		7 GLY A 163
GLU A 186
LYS A 187
ALA A 188
ASP A 222
PHE A 223
ASN A 241
 None
None
None
None
None
None
5F7  A 401 (-3.6A)
 0.43A 5mvsA-5dtrA:
47.7		 5mvsA-5dtrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd CASEIN KINASE I
ISOFORM ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY C 145
ASP C  91
PHE C 154
ASN C 151
 None
 0.99A 5mvsA-5fqdC:
undetectable		 5mvsA-5fqdC:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3

(Rattus
norvegicus) 		PF12796
(Ank_2)
PF16511
(FERM_f0) 		4 GLY A  54
GLU A  70
PHE A  90
ASN A  52
 None
EDO  A1377 ( 4.4A)
None
None
 0.98A 5mvsA-5g4xA:
undetectable		 5mvsA-5g4xA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		4 GLY A 293
GLU A1323
ALA A1324
ASP A 615
 None
 0.82A 5mvsA-5gjvA:
undetectable		 5mvsA-5gjvA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsi PUTATIVE
DECARBOXYLASE

(Lactobacillus
brevis) 		PF00282
(Pyridoxal_deC) 		4 GLY A 468
ALA A 337
PHE A 362
ASN A 504
 None
 1.00A 5mvsA-5hsiA:
undetectable		 5mvsA-5hsiA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLY A1603
ALA A1728
ASP A1559
PHE A1556
ASN A1318
 None
 1.42A 5mvsA-5i8iA:
undetectable		 5mvsA-5i8iA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius) 		PF00891
(Methyltransf_2) 		4 GLY A 187
GLU A 210
ASP A 237
PHE A 238
 SAH  A 401 (-3.9A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.7A)
SAH  A 401 (-3.4A)
 0.66A 5mvsA-5jr3A:
11.2		 5mvsA-5jr3A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m4a NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A 300
GLU A 704
ALA A 701
ASN A 304
 None
 1.00A 5mvsA-5m4aA:
undetectable		 5mvsA-5m4aA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 4 GLY A 307
LYS A 426
ASP A 291
ASN A 309
 None
 0.89A 5mvsA-5oc1A:
2.3		 5mvsA-5oc1A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aom ENDOPLASMIN

(Canis lupus) 		no annotation 4 GLY A 151
ALA A 108
ASP A 113
ASN A 129
 None
VC5  A 409 ( 4.7A)
None
None
 0.92A 5mvsA-6aomA:
undetectable		 5mvsA-6aomA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 4 GLY A 871
ALA A1029
PHE A 839
ASN A 869
 None
 0.98A 5mvsA-6b3eA:
undetectable		 5mvsA-6b3eA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 4 GLY A 293
GLU A1323
ALA A1324
ASP A 615
 None
 0.81A 5mvsA-6byoA:
undetectable		 5mvsA-6byoA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dhi -

(-) 		no annotation 4 GLY A 232
GLU A 208
ALA A 168
ASP A 214
 None
 0.89A 5mvsA-6dhiA:
3.0		 5mvsA-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC6
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC7

(Saccharomyces
cerevisiae) 		no annotation 4 GLY Q  45
GLU P 308
LYS P 307
ASP P 306
 None
 0.97A 5mvsA-6eu2Q:
undetectable		 5mvsA-6eu2Q:
12.46