SIMILAR PATTERNS OF AMINO ACIDS FOR 5MVN_D_PFLD410_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 TYR A 194
ILE A 205
ILE A 182
TYR A 216
ILE A 146
 None
 1.29A 5mvnD-1dq3A:
0.0		 5mvnD-1dq3A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT

(Methanopyrus
kandleri) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 TYR B 334
TYR C 103
TYR C 109
THR C 118
ILE C 127
 None
 1.45A 5mvnD-1e6vB:
0.5		 5mvnD-1e6vB:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		5 PRO A 302
ILE A 299
ILE A 224
TRP A 223
THR A 319
 None
 1.38A 5mvnD-1gjuA:
0.0		 5mvnD-1gjuA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5u ARCHEASE, POSSIBLE
CHAPERONE

(Thermotoga
maritima) 		PF01951
(Archease) 		5 ILE A  71
ILE A 105
VAL A  67
TYR A  19
ILE A  36
 None
 1.38A 5mvnD-1j5uA:
0.0		 5mvnD-1j5uA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		5 TYR A  85
ILE A 181
ILE A 154
VAL A 169
THR A 137
 None
 1.41A 5mvnD-1jjiA:
0.0		 5mvnD-1jjiA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kho ALPHA-TOXIN

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		5 TYR A 338
PRO A 340
ILE A 262
ILE A 343
TYR A 367
 None
 1.47A 5mvnD-1khoA:
3.5		 5mvnD-1khoA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT

(Homo sapiens) 		no annotation 5 ILE B  94
VAL B 120
TYR B 125
THR B 124
ILE B  79
 None
 1.36A 5mvnD-1l1oB:
undetectable		 5mvnD-1l1oB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT

(Homo sapiens) 		no annotation 5 ILE B 146
VAL B 120
TYR B 125
THR B 124
ILE B  79
 None
 1.44A 5mvnD-1l1oB:
undetectable		 5mvnD-1l1oB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		5 TYR A 312
PRO A 318
ILE A 523
THR A 572
ILE A 571
 None
 1.28A 5mvnD-1nugA:
4.1		 5mvnD-1nugA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvj MOLYBDOPTERIN
CONVERTING FACTOR
SUBUNIT 2

(Escherichia
coli) 		PF02391
(MoaE) 		5 PRO A  56
ILE A  85
VAL A   8
TYR A  55
THR A  59
 None
 1.48A 5mvnD-1nvjA:
undetectable		 5mvnD-1nvjA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Haemophilus
influenzae) 		PF00793
(DAHP_synth_1) 		5 TYR A  52
ILE A  92
ILE A  93
VAL A  90
ILE A   8
 None
 1.38A 5mvnD-1o60A:
undetectable		 5mvnD-1o60A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sa3 TYPE II RESTRICTION
ENZYME MSPI

(Moraxella sp.) 		PF09208
(Endonuc-MspI) 		5 TYR A 214
TYR A  37
ILE A  41
ILE A  38
ILE A 219
 None
 1.40A 5mvnD-1sa3A:
undetectable		 5mvnD-1sa3A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uci GUANYL-SPECIFIC
RIBONUCLEASE SA

(Kitasatospora
aureofaciens) 		PF00545
(Ribonuclease) 		5 TYR A  81
ILE A  92
TYR A  55
THR A  18
ILE A  22
 None
 1.34A 5mvnD-1uciA:
undetectable		 5mvnD-1uciA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		5 PRO A 300
TYR A 338
TYR A 303
THR A 304
ILE A 307
 None
 1.49A 5mvnD-1vlpA:
undetectable		 5mvnD-1vlpA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 TYR A 202
PRO A 204
ILE A 332
ILE A 351
THR A 356
 None
 1.17A 5mvnD-2db3A:
undetectable		 5mvnD-2db3A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A 415
ILE A 479
VAL A 419
TYR A 472
ILE A 450
 None
 1.34A 5mvnD-2qyvA:
undetectable		 5mvnD-2qyvA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 TYR A 753
ILE A 808
VAL A 788
THR A 763
ILE A 783
 None
 1.41A 5mvnD-2vsqA:
undetectable		 5mvnD-2vsqA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wuy POLYHEDRIN

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00738
(Polyhedrin) 		5 TYR A 209
ILE A 207
VAL A  87
TYR A 167
ILE A 169
 None
 1.39A 5mvnD-2wuyA:
undetectable		 5mvnD-2wuyA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9m PEROXISOME ASSEMBLY
PROTEIN 22

(Saccharomyces
cerevisiae) 		PF12827
(Peroxin-22) 		5 PRO B  90
ILE B  70
TRP B  77
TYR B 117
ILE B 115
 None
 1.31A 5mvnD-2y9mB:
undetectable		 5mvnD-2y9mB:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 PRO A 123
VAL A  73
TYR A 121
THR A  79
ILE A  36
 None
 1.36A 5mvnD-3abgA:
undetectable		 5mvnD-3abgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay8 GLUTATHIONE
S-TRANSFERASE

(Bombyx mori) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 TYR A  74
TYR A  79
ILE A  27
ILE A  25
ILE A 158
 None
 1.23A 5mvnD-3ay8A:
undetectable		 5mvnD-3ay8A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoj BACTERIOCHLOROPHYLL
A PROTEIN

(Prosthecochloris
aestuarii) 		PF02327
(BChl_A) 		5 TYR A 364
ILE A 287
ILE A 315
VAL A 276
ILE A  18
 None
BCL  A 374 ( 4.3A)
None
BCL  A 375 ( 4.5A)
None
 1.47A 5mvnD-3eojA:
2.6		 5mvnD-3eojA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M) 		5 TYR A  83
ILE A  66
VAL A  68
TYR A  86
THR A  24
 None
 1.34A 5mvnD-3fsxA:
undetectable		 5mvnD-3fsxA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3r ADAPTER PROTEIN MECA
1

(Bacillus
subtilis) 		PF05389
(MecA) 		5 TYR 1 161
ILE 1 212
ILE 1 204
VAL 1 139
TYR 1 155
 None
 1.31A 5mvnD-3j3r1:
undetectable		 5mvnD-3j3r1:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js3 3-DEHYDROQUINATE
DEHYDRATASE

(Clostridioides
difficile) 		PF01487
(DHquinase_I) 		5 TYR A  98
ILE A 114
ILE A 105
VAL A 128
TYR A  97
 None
 1.15A 5mvnD-3js3A:
undetectable		 5mvnD-3js3A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khw POLYMERASE PB2

(Influenza A
virus) 		PF00604
(Flu_PB2) 		5 TYR A 550
ILE A 553
ILE A 554
TRP A 557
TYR A 658
 None
 0.88A 5mvnD-3khwA:
undetectable		 5mvnD-3khwA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lho PUTATIVE HYDROLASE

(Shewanella
frigidimarina) 		PF07063
(DUF1338) 		5 TYR A 160
ILE A 115
ILE A 111
VAL A  51
THR A  45
 None
 1.39A 5mvnD-3lhoA:
undetectable		 5mvnD-3lhoA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqt MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TYR A 189
TYR A 156
ILE A 197
VAL A 205
ILE A 227
 None
 1.49A 5mvnD-3mqtA:
2.1		 5mvnD-3mqtA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 PRO A 493
TYR A 411
ILE A 410
THR A 525
ILE A 526
 None
 1.46A 5mvnD-3ua4A:
undetectable		 5mvnD-3ua4A:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb9 UNCHARACTERIZED
PROTEIN VPA0735

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		5 ILE A 208
ILE A 190
VAL A 224
TYR A 187
ILE A 111
 None
 1.40A 5mvnD-3vb9A:
undetectable		 5mvnD-3vb9A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9y DISKS LARGE HOMOLOG
1

(Homo sapiens) 		PF00625
(Guanylate_kin) 		5 ILE A 909
ILE A 910
VAL A 894
TYR A 903
ILE A 749
 None
 1.13A 5mvnD-3w9yA:
undetectable		 5mvnD-3w9yA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amq L544

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 5 TYR A  11
ILE A  16
ILE A  12
VAL A 181
ILE A  42
 None
 1.47A 5mvnD-4amqA:
2.8		 5mvnD-4amqA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bu0 S-M CHECKPOINT
CONTROL PROTEIN RAD4

(Schizosaccharomyces
pombe) 		PF12738
(PTCB-BRCT) 		5 ILE A 143
TRP A 167
VAL A 107
TYR A 123
ILE A 172
 None
 1.13A 5mvnD-4bu0A:
undetectable		 5mvnD-4bu0A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dey VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-2

(Oryctolagus
cuniculus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		5 PRO A 120
TYR A  71
ILE A  86
VAL A  79
ILE A 106
 None
None
BR  A 510 ( 4.2A)
BR  A 502 (-4.6A)
None
 1.25A 5mvnD-4deyA:
undetectable		 5mvnD-4deyA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		5 ILE A 447
ILE A 449
VAL A 433
TYR A 457
ILE A 427
 None
 1.29A 5mvnD-4hpfA:
undetectable		 5mvnD-4hpfA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifs FACT COMPLEX SUBUNIT
SSRP1

(Homo sapiens) 		PF08512
(Rtt106) 		5 TYR A 214
TYR A 232
ILE A 263
ILE A 234
ILE A 257
 None
 1.42A 5mvnD-4ifsA:
undetectable		 5mvnD-4ifsA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ita SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Synechococcus
sp. PCC 7002) 		PF00171
(Aldedh) 		5 TYR A 341
PRO A 342
VAL A 317
THR A 344
ILE A 345
 None
 1.23A 5mvnD-4itaA:
undetectable		 5mvnD-4itaA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jys PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		5 ILE A  99
ILE A 150
VAL A 183
TYR A  88
ILE A 148
 None
 1.23A 5mvnD-4jysA:
undetectable		 5mvnD-4jysA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfn GALACTOSE-6-PHOSPHAT
E ISOMERASE SUBUNIT
A
GALACTOSE-6-PHOSPHAT
E ISOMERASE SUBUNIT
B

(Lactobacillus
rhamnosus) 		PF02502
(LacAB_rpiB) 		5 TYR B  42
PRO B  43
ILE A 133
TRP B 165
TYR B  45
 RBL  B 201 (-4.1A)
None
None
None
None
 1.20A 5mvnD-4lfnB:
undetectable		 5mvnD-4lfnB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o87 N-TAGGED NUCLEASE

(Millerozyma
acaciae) 		no annotation 5 PRO A   3
TYR A  83
ILE A  84
ILE A  80
THR A   5
 None
 1.13A 5mvnD-4o87A:
undetectable		 5mvnD-4o87A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqg GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
pneumoniae) 		PF00534
(Glycos_transf_1) 		5 ILE A 379
ILE A 356
VAL A 342
TYR A 397
ILE A 324
 None
 1.48A 5mvnD-4pqgA:
undetectable		 5mvnD-4pqgA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6j LMO0131 PROTEIN

(Listeria
monocytogenes) 		PF00563
(EAL) 		5 ILE A 121
ILE A  89
VAL A 147
TYR A 108
ILE A  75
 None
None
None
EDO  A 304 ( 4.1A)
None
 1.36A 5mvnD-4q6jA:
undetectable		 5mvnD-4q6jA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 TYR A 746
PRO A 513
TYR A 293
VAL A 466
TYR A 741
 None
 1.42A 5mvnD-4rbnA:
undetectable		 5mvnD-4rbnA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 TYR A 463
TYR A 467
ILE A 388
TRP A 410
TYR A 461
 None
 1.14A 5mvnD-4ud8A:
undetectable		 5mvnD-4ud8A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8b EXO-XYLOGLUCANASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		5 ILE A 428
ILE A 467
VAL A 336
TYR A 229
ILE A 144
 None
 1.31A 5mvnD-4w8bA:
undetectable		 5mvnD-4w8bA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3

(Homo sapiens) 		PF16953
(PRORP) 		5 PRO A 277
TYR A 307
ILE A 304
THR A 281
ILE A 251
 None
 1.44A 5mvnD-4xgmA:
2.0		 5mvnD-4xgmA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
NORC-LIKE PROTEIN

(Roseobacter
denitrificans) 		PF00034
(Cytochrom_C)
PF00115
(COX1) 		5 PRO A 253
TYR B  35
ILE B  36
TYR A 247
ILE A 250
 None
 1.32A 5mvnD-4xydA:
1.8		 5mvnD-4xydA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 ILE A 208
ILE A 209
TYR A 261
THR A 262
ILE A 265
 None
 0.45A 5mvnD-4yeuA:
19.8		 5mvnD-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 PRO A 120
ILE A 208
ILE A 209
TYR A 261
THR A 262
 None
 0.89A 5mvnD-4yeuA:
19.8		 5mvnD-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 TYR A 204
ILE A 208
ILE A 209
THR A 262
ILE A 265
 None
 0.80A 5mvnD-4yeuA:
19.8		 5mvnD-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr5 NEPRILYSIN

(Oryctolagus
cuniculus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 ILE A 219
ILE A 201
VAL A 344
THR A 327
ILE A 330
 None
 1.30A 5mvnD-4zr5A:
undetectable		 5mvnD-4zr5A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 TYR B 333
TYR C 102
TYR C 108
THR C 117
ILE C 126
 None
 1.42A 5mvnD-5a8rB:
undetectable		 5mvnD-5a8rB:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N) 		5 TYR A 211
ILE A 187
ILE A 190
THR A 173
ILE A 172
 None
 1.43A 5mvnD-5b48A:
undetectable		 5mvnD-5b48A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cag UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF17145
(DUF5119) 		5 TYR A  84
PRO A  58
VAL A  79
TYR A  57
ILE A  55
 None
 1.18A 5mvnD-5cagA:
undetectable		 5mvnD-5cagA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chs RNA-DIRECTED RNA
POLYMERASE L

(Indiana
vesiculovirus) 		PF00946
(Mononeg_RNA_pol) 		5 ILE A 286
ILE A 274
TRP A 358
VAL A 289
ILE A 270
 None
 1.27A 5mvnD-5chsA:
3.1		 5mvnD-5chsA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dv5 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Vibrio
alginolyticus) 		PF00392
(GntR)
PF07840
(FadR_C) 		5 TYR A 184
ILE A 148
VAL A 157
THR A 180
ILE A 177
 PKZ  A 302 (-4.1A)
None
PKZ  A 302 ( 4.2A)
None
None
 1.40A 5mvnD-5dv5A:
undetectable		 5mvnD-5dv5A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmq INFLUENZA A PB2
SUBUNIT

(Influenza A
virus) 		PF00604
(Flu_PB2) 		5 TYR A 550
ILE A 553
ILE A 554
TRP A 557
TYR A 658
 None
 0.89A 5mvnD-5fmqA:
undetectable		 5mvnD-5fmqA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1

(Oryctolagus
cuniculus) 		PF12052
(VGCC_beta4Aa_N) 		5 PRO B 160
TYR B 111
ILE B 126
VAL B 119
ILE B 146
 None
 1.25A 5mvnD-5gjvB:
undetectable		 5mvnD-5gjvB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwj DNA TOPOISOMERASE
2-BETA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 TYR A 534
ILE A 523
ILE A 526
VAL A 509
ILE A 573
 None
 1.26A 5mvnD-5gwjA:
undetectable		 5mvnD-5gwjA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3n GREEN FLUORESCENT
PROTEIN,HSDR

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF12008
(EcoR124_C) 		5 TYR A 342
ILE A 384
ILE A 343
VAL A 380
ILE A 329
 None
 1.28A 5mvnD-5j3nA:
undetectable		 5mvnD-5j3nA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjc CYSTEINE SYNTHASE

(Brucella
abortus) 		PF00291
(PALP) 		5 TYR A 252
ILE A 298
ILE A  28
VAL A 179
ILE A 282
 None
 1.27A 5mvnD-5jjcA:
undetectable		 5mvnD-5jjcA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1q METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT BETA
METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT GAMMA

(Methanothermococcus
thermolithotrophicus) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 TYR B 333
TYR C 102
TYR C 108
THR C 117
ILE C 126
 None
 1.43A 5mvnD-5n1qB:
undetectable		 5mvnD-5n1qB:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(Methanotorris
formicicus) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 TYR B 334
TYR C 102
TYR C 108
THR C 117
ILE C 126
 None
 1.35A 5mvnD-5n28B:
undetectable		 5mvnD-5n28B:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 TYR T 313
ILE T 354
ILE T 310
VAL T 325
TYR T 238
 None
 1.15A 5mvnD-5ojsT:
undetectable		 5mvnD-5ojsT:
1.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 9 TYR C 119
PRO C 120
TYR C 197
ILE C 201
ILE C 202
VAL C 242
TYR C 254
THR C 255
ILE C 258
 None
 0.48A 5mvnD-5v6nC:
35.8		 5mvnD-5v6nC:
97.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbj FLAGELLAR
HOOK-ASSOCIATED
PROTEIN FLGK

(Campylobacter
jejuni) 		no annotation 5 TYR A  89
ILE A 316
ILE A 315
VAL A 161
TYR A  86
 None
 1.08A 5mvnD-5xbjA:
3.3		 5mvnD-5xbjA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xs2 CYCLIN-C

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		5 TYR B 192
ILE B 230
ILE B 197
VAL B 233
THR B 186
 None
 1.18A 5mvnD-5xs2B:
2.4		 5mvnD-5xs2B:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xuo POLYKETIDE SYNTHASE
PKS13

(Mycobacterium
tuberculosis) 		no annotation 5 TYR A 809
ILE A 781
VAL A 744
THR A 820
ILE A 823
 None
 1.17A 5mvnD-5xuoA:
2.2		 5mvnD-5xuoA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 5 PRO A1926
ILE A1905
ILE A1909
TRP A1914
VAL A1935
 None
 1.13A 5mvnD-5y29A:
undetectable		 5mvnD-5y29A:
22.22