SIMILAR PATTERNS OF AMINO ACIDS FOR 5MVN_C_PFLC407_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT

(Homo sapiens) 		no annotation 5 ILE B 146
VAL B 120
TYR B 125
THR B 124
ILE B  79
 None
 1.44A 5mvnC-1l1oB:
0.0		 5mvnC-1l1oB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvj MOLYBDOPTERIN
CONVERTING FACTOR
SUBUNIT 2

(Escherichia
coli) 		PF02391
(MoaE) 		5 PRO A  56
ILE A  85
VAL A   8
TYR A  55
THR A  59
 None
 1.47A 5mvnC-1nvjA:
undetectable		 5mvnC-1nvjA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uci GUANYL-SPECIFIC
RIBONUCLEASE SA

(Kitasatospora
aureofaciens) 		PF00545
(Ribonuclease) 		5 TYR A  81
ILE A  92
TYR A  55
THR A  18
ILE A  22
 None
 1.33A 5mvnC-1uciA:
0.0		 5mvnC-1uciA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wuy POLYHEDRIN

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00738
(Polyhedrin) 		5 TYR A 209
ILE A 207
VAL A  87
TYR A 167
ILE A 169
 None
 1.40A 5mvnC-2wuyA:
0.0		 5mvnC-2wuyA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9m PEROXISOME ASSEMBLY
PROTEIN 22

(Saccharomyces
cerevisiae) 		PF12827
(Peroxin-22) 		5 PRO B  90
ILE B  70
TRP B  77
TYR B 117
ILE B 115
 None
 1.25A 5mvnC-2y9mB:
0.0		 5mvnC-2y9mB:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 PRO A 123
VAL A  73
TYR A 121
THR A  79
ILE A  36
 None
 1.38A 5mvnC-3abgA:
0.0		 5mvnC-3abgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M) 		5 TYR A  83
ILE A  66
VAL A  68
TYR A  86
THR A  24
 None
 1.33A 5mvnC-3fsxA:
undetectable		 5mvnC-3fsxA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bu0 S-M CHECKPOINT
CONTROL PROTEIN RAD4

(Schizosaccharomyces
pombe) 		PF12738
(PTCB-BRCT) 		5 ILE A 143
TRP A 167
VAL A 107
TYR A 123
ILE A 172
 None
 1.15A 5mvnC-4bu0A:
0.0		 5mvnC-4bu0A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ita SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Synechococcus
sp. PCC 7002) 		PF00171
(Aldedh) 		5 TYR A 341
PRO A 342
VAL A 317
THR A 344
ILE A 345
 None
 1.24A 5mvnC-4itaA:
0.0		 5mvnC-4itaA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfn GALACTOSE-6-PHOSPHAT
E ISOMERASE SUBUNIT
A
GALACTOSE-6-PHOSPHAT
E ISOMERASE SUBUNIT
B

(Lactobacillus
rhamnosus) 		PF02502
(LacAB_rpiB) 		5 TYR B  42
PRO B  43
ILE A 133
TRP B 165
TYR B  45
 RBL  B 201 (-4.1A)
None
None
None
None
 1.19A 5mvnC-4lfnB:
undetectable		 5mvnC-4lfnB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 TYR A 746
PRO A 513
TYR A 293
VAL A 466
TYR A 741
 None
 1.41A 5mvnC-4rbnA:
1.7		 5mvnC-4rbnA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 TYR A 463
TYR A 467
ILE A 388
TRP A 410
TYR A 461
 None
 1.13A 5mvnC-4ud8A:
0.2		 5mvnC-4ud8A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3

(Homo sapiens) 		PF16953
(PRORP) 		5 PRO A 277
TYR A 307
ILE A 304
THR A 281
ILE A 251
 None
 1.43A 5mvnC-4xgmA:
2.0		 5mvnC-4xgmA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PRO A 338
TYR A 458
ILE A 459
TYR A 337
THR A 336
 None
 1.45A 5mvnC-4ynuA:
0.9		 5mvnC-4ynuA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 TYR B 333
TYR C 102
TYR C 108
THR C 117
ILE C 126
 None
 1.43A 5mvnC-5a8rB:
1.1		 5mvnC-5a8rB:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cag UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF17145
(DUF5119) 		5 TYR A  84
PRO A  58
VAL A  79
TYR A  57
ILE A  55
 None
 1.17A 5mvnC-5cagA:
undetectable		 5mvnC-5cagA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dv5 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Vibrio
alginolyticus) 		PF00392
(GntR)
PF07840
(FadR_C) 		5 TYR A 184
ILE A 148
VAL A 157
THR A 180
ILE A 177
 PKZ  A 302 (-4.1A)
None
PKZ  A 302 ( 4.2A)
None
None
 1.40A 5mvnC-5dv5A:
undetectable		 5mvnC-5dv5A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1q METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT BETA
METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT GAMMA

(Methanothermococcus
thermolithotrophicus) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 TYR B 333
TYR C 102
TYR C 108
THR C 117
ILE C 126
 None
 1.43A 5mvnC-5n1qB:
1.0		 5mvnC-5n1qB:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(Methanotorris
formicicus) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 TYR B 334
TYR C 102
TYR C 108
THR C 117
ILE C 126
 None
 1.36A 5mvnC-5n28B:
1.1		 5mvnC-5n28B:
11.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 8 TYR C 119
PRO C 120
TYR C 197
ILE C 201
VAL C 242
TYR C 254
THR C 255
ILE C 258
 None
 0.49A 5mvnC-5v6nC:
35.7		 5mvnC-5v6nC:
97.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xuo POLYKETIDE SYNTHASE
PKS13

(Mycobacterium
tuberculosis) 		no annotation 5 TYR A 809
ILE A 781
VAL A 744
THR A 820
ILE A 823
 None
 1.17A 5mvnC-5xuoA:
2.2		 5mvnC-5xuoA:
18.39