SIMILAR PATTERNS OF AMINO ACIDS FOR 5MVN_B_PFLB410

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 TYR A 194
ILE A 205
ILE A 182
TYR A 216
ILE A 146
 None
 1.31A 5mvnB-1dq3A:
0.0		 5mvnB-1dq3A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II

(Saccharomyces
cerevisiae) 		PF00150
(Cellulase) 		5 TYR A 220
ILE A 160
ILE A 223
VAL A 172
ILE A 225
 None
 1.47A 5mvnB-1h4pA:
0.0		 5mvnB-1h4pA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5u ARCHEASE, POSSIBLE
CHAPERONE

(Thermotoga
maritima) 		PF01951
(Archease) 		5 ILE A  71
ILE A 105
VAL A  67
TYR A  19
ILE A  36
 None
 1.39A 5mvnB-1j5uA:
0.0		 5mvnB-1j5uA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT

(Homo sapiens) 		no annotation 5 ILE B 146
VAL B 120
TYR B 125
THR B 124
ILE B  79
 None
 1.44A 5mvnB-1l1oB:
undetectable		 5mvnB-1l1oB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvj MOLYBDOPTERIN
CONVERTING FACTOR
SUBUNIT 2

(Escherichia
coli) 		PF02391
(MoaE) 		5 PRO A  56
ILE A  85
VAL A   8
TYR A  55
THR A  59
 None
 1.48A 5mvnB-1nvjA:
undetectable		 5mvnB-1nvjA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uci GUANYL-SPECIFIC
RIBONUCLEASE SA

(Kitasatospora
aureofaciens) 		PF00545
(Ribonuclease) 		5 TYR A  81
ILE A  92
TYR A  55
THR A  18
ILE A  22
 None
 1.33A 5mvnB-1uciA:
0.0		 5mvnB-1uciA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		5 PRO A 300
TYR A 338
TYR A 303
THR A 304
ILE A 307
 None
 1.50A 5mvnB-1vlpA:
0.0		 5mvnB-1vlpA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 TYR A  91
ILE A 128
VAL A  71
TYR A  48
ILE A  52
 None
 1.11A 5mvnB-2pokA:
0.0		 5mvnB-2pokA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A 415
ILE A 479
VAL A 419
TYR A 472
ILE A 450
 None
 1.36A 5mvnB-2qyvA:
1.6		 5mvnB-2qyvA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wuy POLYHEDRIN

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00738
(Polyhedrin) 		5 TYR A 209
ILE A 207
VAL A  87
TYR A 167
ILE A 169
 None
 1.40A 5mvnB-2wuyA:
undetectable		 5mvnB-2wuyA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 PRO A 131
ILE A 182
ILE A 184
THR A 164
ILE A 213
 None
 1.33A 5mvnB-2yv2A:
undetectable		 5mvnB-2yv2A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 PRO A 131
ILE A 184
VAL A 181
THR A 164
ILE A 213
 None
 1.47A 5mvnB-2yv2A:
undetectable		 5mvnB-2yv2A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 PRO A 123
VAL A  73
TYR A 121
THR A  79
ILE A  36
 None
 1.38A 5mvnB-3abgA:
1.5		 5mvnB-3abgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoj BACTERIOCHLOROPHYLL
A PROTEIN

(Prosthecochloris
aestuarii) 		PF02327
(BChl_A) 		5 TYR A 364
ILE A 287
ILE A 315
VAL A 276
ILE A  18
 None
BCL  A 374 ( 4.3A)
None
BCL  A 375 ( 4.5A)
None
 1.48A 5mvnB-3eojA:
2.6		 5mvnB-3eojA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 PRO A 493
TYR A 411
ILE A 410
THR A 525
ILE A 526
 None
 1.43A 5mvnB-3ua4A:
undetectable		 5mvnB-3ua4A:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9y DISKS LARGE HOMOLOG
1

(Homo sapiens) 		PF00625
(Guanylate_kin) 		5 ILE A 909
ILE A 910
VAL A 894
TYR A 903
ILE A 749
 None
 1.12A 5mvnB-3w9yA:
undetectable		 5mvnB-3w9yA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		5 TYR A 146
ILE A 182
ILE A 804
TRP A 599
VAL A 777
 None
 1.40A 5mvnB-4a5wA:
undetectable		 5mvnB-4a5wA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dey VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-2

(Oryctolagus
cuniculus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		5 PRO A 120
TYR A  71
ILE A  86
VAL A  79
ILE A 106
 None
None
BR  A 510 ( 4.2A)
BR  A 502 (-4.6A)
None
 1.25A 5mvnB-4deyA:
undetectable		 5mvnB-4deyA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv8 DUTPASE

(Staphylococcus
virus 11) 		PF00692
(dUTPase) 		5 TYR A 126
ILE A 110
ILE A 128
VAL A  67
ILE A  90
 None
 1.15A 5mvnB-4gv8A:
undetectable		 5mvnB-4gv8A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		5 ILE A 447
ILE A 449
VAL A 433
TYR A 457
ILE A 427
 None
 1.30A 5mvnB-4hpfA:
undetectable		 5mvnB-4hpfA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o87 N-TAGGED NUCLEASE

(Millerozyma
acaciae) 		no annotation 5 PRO A   3
TYR A  83
ILE A  84
ILE A  80
THR A   5
 None
 1.12A 5mvnB-4o87A:
undetectable		 5mvnB-4o87A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqg GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
pneumoniae) 		PF00534
(Glycos_transf_1) 		5 ILE A 379
ILE A 356
VAL A 342
TYR A 397
ILE A 324
 None
 1.46A 5mvnB-4pqgA:
undetectable		 5mvnB-4pqgA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6j LMO0131 PROTEIN

(Listeria
monocytogenes) 		PF00563
(EAL) 		5 ILE A 121
ILE A  89
VAL A 147
TYR A 108
ILE A  75
 None
None
None
EDO  A 304 ( 4.1A)
None
 1.38A 5mvnB-4q6jA:
undetectable		 5mvnB-4q6jA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3

(Homo sapiens) 		PF16953
(PRORP) 		5 PRO A 277
TYR A 307
ILE A 304
THR A 281
ILE A 251
 None
 1.44A 5mvnB-4xgmA:
2.0		 5mvnB-4xgmA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
NORC-LIKE PROTEIN

(Roseobacter
denitrificans) 		PF00034
(Cytochrom_C)
PF00115
(COX1) 		5 PRO A 253
TYR B  35
ILE B  36
TYR A 247
ILE A 250
 None
 1.31A 5mvnB-4xydA:
2.4		 5mvnB-4xydA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 ILE A 208
ILE A 209
TYR A 261
THR A 262
ILE A 265
 None
 0.49A 5mvnB-4yeuA:
19.7		 5mvnB-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 TYR A 204
ILE A 208
ILE A 209
THR A 262
ILE A 265
 None
 0.83A 5mvnB-4yeuA:
19.7		 5mvnB-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PRO A 338
TYR A 458
ILE A 459
TYR A 337
THR A 336
 None
 1.43A 5mvnB-4ynuA:
undetectable		 5mvnB-4ynuA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr5 NEPRILYSIN

(Oryctolagus
cuniculus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 ILE A 219
ILE A 201
VAL A 344
THR A 327
ILE A 330
 None
 1.28A 5mvnB-4zr5A:
1.8		 5mvnB-4zr5A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1

(Oryctolagus
cuniculus) 		PF12052
(VGCC_beta4Aa_N) 		5 PRO B 160
TYR B 111
ILE B 126
VAL B 119
ILE B 146
 None
 1.25A 5mvnB-5gjvB:
undetectable		 5mvnB-5gjvB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3n GREEN FLUORESCENT
PROTEIN,HSDR

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF12008
(EcoR124_C) 		5 TYR A 342
ILE A 384
ILE A 343
VAL A 380
ILE A 329
 None
 1.28A 5mvnB-5j3nA:
1.2		 5mvnB-5j3nA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 TYR T 313
ILE T 354
ILE T 310
VAL T 325
TYR T 238
 None
 1.15A 5mvnB-5ojsT:
undetectable		 5mvnB-5ojsT:
1.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 8 PRO C 120
TYR C 197
ILE C 201
ILE C 202
VAL C 242
TYR C 254
THR C 255
ILE C 258
 None
 0.54A 5mvnB-5v6nC:
35.6		 5mvnB-5v6nC:
97.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 5 ILE A 354
ILE A 406
VAL A 376
THR A 373
ILE A 338
 None
 1.36A 5mvnB-5xgjA:
1.9		 5mvnB-5xgjA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xs2 CYCLIN-C

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		5 TYR B 192
ILE B 230
ILE B 197
VAL B 233
THR B 186
 None
 1.19A 5mvnB-5xs2B:
undetectable		 5mvnB-5xs2B:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xuo POLYKETIDE SYNTHASE
PKS13

(Mycobacterium
tuberculosis) 		no annotation 5 TYR A 809
ILE A 781
VAL A 744
THR A 820
ILE A 823
 None
 1.17A 5mvnB-5xuoA:
2.2		 5mvnB-5xuoA:
18.39