SIMILAR PATTERNS OF AMINO ACIDS FOR 5MVM_E_PFLE409

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2z PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermococcus
litoralis) 		PF01470
(Peptidase_C15) 		5 LEU A  68
ILE A 195
ALA A 197
ILE A 198
ILE A 130
 None
 1.00A 5mvmD-1a2zA:
0.0
5mvmE-1a2zA:
0.0		 5mvmD-1a2zA:
17.79
5mvmE-1a2zA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)

(Planomicrobium
okeanokoites) 		PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3) 		5 ILE A 267
LEU A 275
ALA A 162
ILE A 163
ILE A 230
 None
 0.94A 5mvmD-1fokA:
undetectable
5mvmE-1fokA:
0.0		 5mvmD-1fokA:
11.04
5mvmE-1fokA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		5 ILE A 103
PRO A 105
ALA A  91
ILE A  62
ALA A  60
 None
 0.89A 5mvmD-1ghsA:
0.0
5mvmE-1ghsA:
undetectable		 5mvmD-1ghsA:
15.83
5mvmE-1ghsA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htr GASTRICSIN
PROGASTRICSIN (PRO
SEGMENT)

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		6 PRO B 226
ALA P  35
ILE B 303
ALA B 214
ILE B 215
ILE B 195
 None
 1.15A 5mvmD-1htrB:
0.0
5mvmE-1htrB:
undetectable		 5mvmD-1htrB:
17.39
5mvmE-1htrB:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		5 ILE A 222
ALA A 292
LEU A 295
ILE A 241
ILE A 244
 None
 0.94A 5mvmD-1j1uA:
0.0
5mvmE-1j1uA:
0.0		 5mvmD-1j1uA:
16.53
5mvmE-1j1uA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6r HYPOTHETICAL PROTEIN
TA0175

(Thermoplasma
acidophilum) 		PF08282
(Hydrolase_3) 		5 ILE A  58
ILE A  20
ALA A  24
ILE A  25
ILE A 214
 None
 1.05A 5mvmD-1l6rA:
0.0
5mvmE-1l6rA:
0.0		 5mvmD-1l6rA:
15.28
5mvmE-1l6rA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		5 ILE A 432
ALA A 394
ALA A 412
ILE A 413
ILE A 551
 None
 0.91A 5mvmD-1nbwA:
0.0
5mvmE-1nbwA:
0.0		 5mvmD-1nbwA:
8.64
5mvmE-1nbwA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9r AGROBACTERIUM
TUMEFACIENS DPS

(Agrobacterium
tumefaciens) 		PF00210
(Ferritin) 		5 ALA A 142
ILE A 121
ALA A 124
ILE A 125
ILE A  21
 None
 0.86A 5mvmD-1o9rA:
3.6
5mvmE-1o9rA:
3.6		 5mvmD-1o9rA:
15.53
5mvmE-1o9rA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3n HYPOTHETICAL PROTEIN
MJ0936

(Methanocaldococcus
jannaschii) 		PF12850
(Metallophos_2) 		6 ILE A  53
LEU A  49
ILE A  16
ALA A  19
ILE A  20
ILE A 150
 None
 1.21A 5mvmD-1s3nA:
undetectable
5mvmE-1s3nA:
0.0		 5mvmD-1s3nA:
16.75
5mvmE-1s3nA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE

(Salmonella
enterica) 		PF02525
(Flavodoxin_2) 		5 ILE A 164
LEU A  84
ILE A  92
ALA A 135
ILE A  90
 None
 0.88A 5mvmD-1t5bA:
undetectable
5mvmE-1t5bA:
undetectable		 5mvmD-1t5bA:
19.34
5mvmE-1t5bA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuf DIAMINOPIMELATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ALA A 160
LEU A 163
ILE A 134
ILE A 135
GLU A 139
 None
 1.01A 5mvmD-1tufA:
undetectable
5mvmE-1tufA:
undetectable		 5mvmD-1tufA:
10.51
5mvmE-1tufA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF14519
(Macro_2) 		5 ILE A 231
ALA A 212
LEU A 215
ILE A 271
ILE A 275
 None
 1.02A 5mvmD-1txzA:
undetectable
5mvmE-1txzA:
undetectable		 5mvmD-1txzA:
14.59
5mvmE-1txzA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0s CHEMOTAXIS PROTEIN
CHEA
CHEMOTAXIS PROTEIN
CHEY

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF07194
(P2) 		5 LEU A 198
ILE Y  91
ALA Y  93
ILE Y  94
ILE Y  55
 None
 1.02A 5mvmD-1u0sA:
undetectable
5mvmE-1u0sA:
undetectable		 5mvmD-1u0sA:
19.32
5mvmE-1u0sA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA B 221
LEU B 224
ILE B 314
ALA B 317
ILE B 290
 None
 0.66A 5mvmD-1umbB:
undetectable
5mvmE-1umbB:
undetectable		 5mvmD-1umbB:
12.34
5mvmE-1umbB:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm9 PLAKOPHILIN 1

(Homo sapiens) 		PF00514
(Arm) 		5 ILE A 430
LEU A 433
ILE A 381
ALA A 376
ILE A 380
 None
 1.04A 5mvmD-1xm9A:
1.7
5mvmE-1xm9A:
1.7		 5mvmD-1xm9A:
10.07
5mvmE-1xm9A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7p HYPOTHETICAL PROTEIN
AF1403

(Archaeoglobus
fulgidus) 		PF01842
(ACT) 		5 ILE A 170
ALA A 144
ALA A 199
ILE A 203
ILE A 173
 None
 1.04A 5mvmD-1y7pA:
undetectable
5mvmE-1y7pA:
undetectable		 5mvmD-1y7pA:
15.56
5mvmE-1y7pA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 ILE A 611
ALA A 659
LEU A 666
ILE A 674
ALA A 626
 None
 1.02A 5mvmD-1yq2A:
1.3
5mvmE-1yq2A:
1.3		 5mvmD-1yq2A:
6.56
5mvmE-1yq2A:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		5 ILE A 367
PRO A 477
ILE A 452
ALA A 455
ILE A 456
 None
 0.89A 5mvmD-1ytmA:
undetectable
5mvmE-1ytmA:
undetectable		 5mvmD-1ytmA:
10.71
5mvmE-1ytmA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvd RAS-RELATED PROTEIN
RAB-22A

(Mus musculus) 		PF00071
(Ras) 		5 ILE A  83
LEU A 103
ALA A  80
ILE A 111
ILE A 162
 None
 1.00A 5mvmD-1yvdA:
undetectable
5mvmE-1yvdA:
undetectable		 5mvmD-1yvdA:
18.45
5mvmE-1yvdA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahd PHOSPHODIESTERASE
MJ0936

(Methanocaldococcus
jannaschii) 		PF12850
(Metallophos_2) 		5 LEU A  49
ILE A  16
ALA A  19
ILE A  20
ILE A 150
 None
 0.92A 5mvmD-2ahdA:
undetectable
5mvmE-2ahdA:
undetectable		 5mvmD-2ahdA:
19.02
5mvmE-2ahdA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS

(Bacillus
subtilis) 		PF02898
(NO_synthase) 		5 LEU A  48
ILE A 106
ALA A 229
ILE A 108
TYR A 351
 None
HEM  A 901 ( 4.8A)
None
None
HEM  A 901 (-4.4A)
 1.03A 5mvmD-2an2A:
undetectable
5mvmE-2an2A:
undetectable		 5mvmD-2an2A:
12.75
5mvmE-2an2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdu NADPH OXIDASE

(Lactobacillus
sanfranciscensis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		6 ALA A 146
LEU A 142
ILE A 152
ALA A 239
ILE A 240
ILE A 224
 None
 1.31A 5mvmD-2cduA:
undetectable
5mvmE-2cduA:
undetectable		 5mvmD-2cduA:
11.82
5mvmE-2cduA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5i AZO REDUCTASE

(Escherichia
coli) 		PF02525
(Flavodoxin_2) 		5 ILE A 163
LEU A  83
ILE A  91
ALA A 134
ILE A  89
 None
 0.87A 5mvmD-2d5iA:
undetectable
5mvmE-2d5iA:
undetectable		 5mvmD-2d5iA:
17.33
5mvmE-2d5iA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 ALA A 342
LEU A 345
ILE A 340
ALA A 404
ILE A 399
 None
 0.97A 5mvmD-2eo5A:
undetectable
5mvmE-2eo5A:
undetectable		 5mvmD-2eo5A:
11.57
5mvmE-2eo5A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6s CELL FILAMENTATION
PROTEIN, PUTATIVE

(Helicobacter
pylori) 		PF02661
(Fic) 		5 ILE A 165
ALA A  11
ILE A 108
ILE A  20
ILE A 121
 None
 0.96A 5mvmD-2f6sA:
undetectable
5mvmE-2f6sA:
undetectable		 5mvmD-2f6sA:
13.99
5mvmE-2f6sA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9r SPHINGOMYELINASE D 1

(Loxosceles
laeta) 		no annotation 5 ILE A 258
PRO A 254
LEU A 261
ILE A 249
ILE A   7
 None
 1.00A 5mvmD-2f9rA:
undetectable
5mvmE-2f9rA:
undetectable		 5mvmD-2f9rA:
14.74
5mvmE-2f9rA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fex CONSERVED
HYPOTHETICAL PROTEIN

(Agrobacterium
fabrum) 		PF01965
(DJ-1_PfpI) 		5 ILE A 165
ILE A  32
ALA A   5
ILE A   6
ILE A  64
 None
 1.01A 5mvmD-2fexA:
undetectable
5mvmE-2fexA:
undetectable		 5mvmD-2fexA:
17.02
5mvmE-2fexA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fno AGR_PAT_752P

(Agrobacterium
fabrum) 		no annotation 5 ILE A  87
LEU A  88
ALA A  78
ILE A  79
ILE A  22
 None
 1.04A 5mvmD-2fnoA:
2.4
5mvmE-2fnoA:
2.4		 5mvmD-2fnoA:
15.45
5mvmE-2fnoA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l5l THIOREDOXIN

(Bacteroides
vulgatus) 		PF00085
(Thioredoxin) 		6 ILE A  96
LEU A  60
ILE A  71
ALA A  41
ILE A  73
ILE A  99
 None
 1.33A 5mvmD-2l5lA:
undetectable
5mvmE-2l5lA:
undetectable		 5mvmD-2l5lA:
18.94
5mvmE-2l5lA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		5 ILE A 115
LEU A  88
ILE A  39
ALA A  42
ILE A  43
 None
 0.72A 5mvmD-2paaA:
undetectable
5mvmE-2paaA:
undetectable		 5mvmD-2paaA:
12.36
5mvmE-2paaA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk9 PHO85 CYCLIN PHO80

(Saccharomyces
cerevisiae) 		PF08613
(Cyclin) 		5 ILE B  77
ALA B 119
LEU B 123
ILE B 102
ILE B 224
 None
 0.98A 5mvmD-2pk9B:
undetectable
5mvmE-2pk9B:
undetectable		 5mvmD-2pk9B:
13.94
5mvmE-2pk9B:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzu PUTATIVE SULFATASE
YIDJ

(Bacteroides
fragilis) 		PF00884
(Sulfatase) 		5 ILE A 294
LEU A 297
ILE A 209
ALA A 208
ILE A 212
 None
 0.99A 5mvmD-2qzuA:
undetectable
5mvmE-2qzuA:
undetectable		 5mvmD-2qzuA:
10.53
5mvmE-2qzuA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzu PUTATIVE SULFATASE
YIDJ

(Bacteroides
fragilis) 		PF00884
(Sulfatase) 		5 LEU A 297
ILE A 209
ALA A 208
ILE A 212
ILE A 130
 None
 0.96A 5mvmD-2qzuA:
undetectable
5mvmE-2qzuA:
undetectable		 5mvmD-2qzuA:
10.53
5mvmE-2qzuA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfb CYTOCHROME P450

(Picrophilus
torridus) 		PF00067
(p450) 		5 ILE A 115
ALA A 317
ILE A 316
ILE A 206
TYR A 107
 None
 0.96A 5mvmD-2rfbA:
undetectable
5mvmE-2rfbA:
undetectable		 5mvmD-2rfbA:
13.04
5mvmE-2rfbA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yl2 ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A 160
ILE A 237
ALA A 234
ILE A 233
ILE A 264
 None
 1.00A 5mvmD-2yl2A:
undetectable
5mvmE-2yl2A:
undetectable		 5mvmD-2yl2A:
9.81
5mvmE-2yl2A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr1 3-DEHYDROQUINATE
DEHYDRATASE

(Geobacillus
kaustophilus) 		PF01487
(DHquinase_I) 		5 ILE A  13
LEU A  48
ILE A 172
ALA A 225
ILE A   3
 None
 1.03A 5mvmD-2yr1A:
undetectable
5mvmE-2yr1A:
undetectable		 5mvmD-2yr1A:
16.14
5mvmE-2yr1A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE

(Bacillus virus
NIT1) 		PF05908
(Gamma_PGA_hydro) 		5 ILE A 152
PRO A  39
ALA A  89
LEU A  93
ILE A  35
 None
 1.04A 5mvmD-3a9lA:
undetectable
5mvmE-3a9lA:
undetectable		 5mvmD-3a9lA:
18.27
5mvmE-3a9lA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beu TRYPSIN

(Streptomyces
griseus) 		PF00089
(Trypsin) 		5 PRO A  92
ALA A 104
LEU A 105
ALA A 237
ILE A 238
 None
 0.88A 5mvmD-3beuA:
undetectable
5mvmE-3beuA:
undetectable		 5mvmD-3beuA:
19.44
5mvmE-3beuA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boe CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 ILE A 229
ALA A 232
LEU A 233
ILE A 412
ALA A 414
 None
 0.98A 5mvmD-3boeA:
undetectable
5mvmE-3boeA:
undetectable		 5mvmD-3boeA:
18.03
5mvmE-3boeA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 PRO A  83
LEU A 103
ALA A  91
ILE A  92
ILE A  37
 None
 1.05A 5mvmD-3ct4A:
undetectable
5mvmE-3ct4A:
undetectable		 5mvmD-3ct4A:
15.77
5mvmE-3ct4A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dli METHYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF13489
(Methyltransf_23) 		5 ILE A 348
ILE A 470
ALA A 468
ILE A 469
TYR A 276
 None
 1.04A 5mvmD-3dliA:
undetectable
5mvmE-3dliA:
undetectable		 5mvmD-3dliA:
14.83
5mvmE-3dliA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e21 FAS-ASSOCIATED
FACTOR 1

(Homo sapiens) 		PF14555
(UBA_4) 		5 ILE A  10
ILE A  23
ALA A  26
ILE A  27
ILE A  20
 None
 0.99A 5mvmD-3e21A:
undetectable
5mvmE-3e21A:
undetectable		 5mvmD-3e21A:
24.00
5mvmE-3e21A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 ILE A 157
LEU A 183
ILE A 228
ILE A 167
ILE A 223
 None
 0.97A 5mvmD-3eb0A:
undetectable
5mvmE-3eb0A:
undetectable		 5mvmD-3eb0A:
11.70
5mvmE-3eb0A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY

(Bacillus
anthracis) 		PF02567
(PhzC-PhzF) 		5 ILE A 142
ALA A 139
LEU A 138
ILE A 155
ILE A 200
 None
 0.95A 5mvmD-3ednA:
undetectable
5mvmE-3ednA:
undetectable		 5mvmD-3ednA:
14.72
5mvmE-3ednA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fot 15-O-ACETYLTRANSFERA
SE

(Fusarium
sporotrichioides) 		PF07428
(Tri3) 		5 ILE A 437
ALA A 477
LEU A 435
ILE A  39
TYR A  51
 GOL  A 524 ( 4.2A)
None
None
None
None
 1.01A 5mvmD-3fotA:
undetectable
5mvmE-3fotA:
undetectable		 5mvmD-3fotA:
11.06
5mvmE-3fotA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		5 ILE A  81
ALA A  50
LEU A  53
ALA A  96
ILE A  97
 None
 0.68A 5mvmD-3hc1A:
undetectable
5mvmE-3hc1A:
undetectable		 5mvmD-3hc1A:
15.41
5mvmE-3hc1A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		5 ILE A 181
ILE A 236
ALA A 238
ILE A 237
ILE A 104
 None
 1.02A 5mvmD-3hvyA:
undetectable
5mvmE-3hvyA:
undetectable		 5mvmD-3hvyA:
17.62
5mvmE-3hvyA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihl CTP SYNTHASE 2

(Homo sapiens) 		PF06418
(CTP_synth_N) 		5 ILE A  26
LEU A 257
ILE A  18
ALA A  20
ILE A  19
 None
None
ADP  A 300 (-4.3A)
None
None
 1.02A 5mvmD-3ihlA:
undetectable
5mvmE-3ihlA:
undetectable		 5mvmD-3ihlA:
13.28
5mvmE-3ihlA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 ILE A 336
ALA A 338
LEU A 339
ILE A 285
ALA A 314
 None
 0.99A 5mvmD-3juxA:
4.8
5mvmE-3juxA:
4.4		 5mvmD-3juxA:
7.32
5mvmE-3juxA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzl PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
monocytogenes) 		PF06838
(Met_gamma_lyase) 		5 ILE A 164
ILE A 219
ALA A 221
ILE A 220
ILE A  89
 None
 1.04A 5mvmD-3jzlA:
undetectable
5mvmE-3jzlA:
undetectable		 5mvmD-3jzlA:
11.33
5mvmE-3jzlA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF01823
(MACPF) 		6 ILE A 291
ALA A 241
LEU A 179
ALA A 263
ILE A 264
ILE A 301
 None
 1.20A 5mvmD-3kk7A:
undetectable
5mvmE-3kk7A:
undetectable		 5mvmD-3kk7A:
9.23
5mvmE-3kk7A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Toxoplasma
gondii) 		PF01048
(PNP_UDP_1) 		5 LEU A 195
ILE A 201
ALA A  84
ILE A  80
GLU A  81
 None
 0.95A 5mvmD-3mb8A:
undetectable
5mvmE-3mb8A:
undetectable		 5mvmD-3mb8A:
16.48
5mvmE-3mb8A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 ILE B 145
PRO B 143
ALA B 176
LEU B 175
ILE B 138
 None
SF4  B 585 (-3.8A)
SF4  B 585 ( 4.7A)
None
None
 1.02A 5mvmD-3mm5B:
undetectable
5mvmE-3mm5B:
undetectable		 5mvmD-3mm5B:
10.22
5mvmE-3mm5B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuz PUTATIVE ACETYL
XYLAN ESTERASE

(Bacteroides
fragilis) 		PF12715
(Abhydrolase_7) 		5 ILE A 272
ALA A 274
ALA A 139
ILE A 140
ILE A 245
 None
 1.04A 5mvmD-3nuzA:
undetectable
5mvmE-3nuzA:
undetectable		 5mvmD-3nuzA:
12.57
5mvmE-3nuzA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oev PROTEASOME COMPONENT
C1

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		6 ILE F 137
ALA F 164
ILE F 196
ALA F 193
ILE F  40
ILE F 212
 None
 1.40A 5mvmD-3oevF:
undetectable
5mvmE-3oevF:
undetectable		 5mvmD-3oevF:
16.33
5mvmE-3oevF:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oji ABSCISIC ACID
RECEPTOR PYL3

(Arabidopsis
thaliana) 		PF10604
(Polyketide_cyc2) 		5 ILE A 203
ALA A 201
LEU A 200
ALA A  64
ILE A  65
 None
 0.93A 5mvmD-3ojiA:
undetectable
5mvmE-3ojiA:
undetectable		 5mvmD-3ojiA:
20.23
5mvmE-3ojiA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdk PHOSPHOGLUCOSAMINE
MUTASE

(Bacillus
anthracis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ILE A 235
ALA A 345
LEU A 348
ILE A 261
ILE A 255
 None
 0.96A 5mvmD-3pdkA:
undetectable
5mvmE-3pdkA:
undetectable		 5mvmD-3pdkA:
11.59
5mvmE-3pdkA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3v PHOSPHOGLYCERATE
KINASE

(Campylobacter
jejuni) 		PF00162
(PGK) 		5 ILE A 112
LEU A  85
ILE A  39
ALA A  42
ILE A  43
 None
 0.72A 5mvmD-3q3vA:
undetectable
5mvmE-3q3vA:
undetectable		 5mvmD-3q3vA:
10.95
5mvmE-3q3vA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t32 AMINOTRANSFERASE,
CLASS I/II

(Bacillus
anthracis) 		PF00155
(Aminotran_1_2) 		5 ILE A  91
ALA A  94
LEU A  95
ILE A 223
ALA A 194
 LLP  A 230 ( 4.2A)
None
None
None
None
 1.04A 5mvmD-3t32A:
undetectable
5mvmE-3t32A:
undetectable		 5mvmD-3t32A:
12.37
5mvmE-3t32A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3x OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A  92
ALA A 105
LEU A 104
ALA A  95
ILE A  39
 None
 0.99A 5mvmD-3u3xA:
undetectable
5mvmE-3u3xA:
undetectable		 5mvmD-3u3xA:
12.78
5mvmE-3u3xA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucf DEHYDROGENASE

(Vibrio
vulnificus) 		PF13561
(adh_short_C2) 		5 ILE A  64
LEU A  22
ILE A 196
ALA A 199
ILE A 214
 None
 0.98A 5mvmD-3ucfA:
undetectable
5mvmE-3ucfA:
undetectable		 5mvmD-3ucfA:
20.13
5mvmE-3ucfA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 ILE A 379
ALA A 341
LEU A 344
ILE A 370
ILE A 383
 None
 1.03A 5mvmD-4c30A:
undetectable
5mvmE-4c30A:
undetectable		 5mvmD-4c30A:
9.24
5mvmE-4c30A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 6 ILE A 334
LEU A 333
ILE A 414
ALA A 413
ILE A 319
TYR A 337
 None
 1.35A 5mvmD-4cyjA:
undetectable
5mvmE-4cyjA:
undetectable		 5mvmD-4cyjA:
11.58
5mvmE-4cyjA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Campylobacter
jejuni) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 ALA A 310
LEU A 309
ILE A 321
ILE A 301
ILE A 264
 None
 1.05A 5mvmD-4ehiA:
2.7
5mvmE-4ehiA:
undetectable		 5mvmD-4ehiA:
9.33
5mvmE-4ehiA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ese FMN-DEPENDENT
NADH-AZOREDUCTASE

(Yersinia pestis) 		PF02525
(Flavodoxin_2) 		5 ILE A 164
LEU A  84
ILE A  92
ALA A 135
ILE A  90
 None
 0.88A 5mvmD-4eseA:
undetectable
5mvmE-4eseA:
undetectable		 5mvmD-4eseA:
17.88
5mvmE-4eseA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 ILE A 189
ALA A 191
ALA A 216
ILE A 217
ILE A 158
 None
 1.00A 5mvmD-4eyoA:
undetectable
5mvmE-4eyoA:
undetectable		 5mvmD-4eyoA:
15.38
5mvmE-4eyoA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		5 PRO A 299
LEU A 149
ILE A 247
ILE A 249
ILE A 266
 None
 0.98A 5mvmD-4fl0A:
undetectable
5mvmE-4fl0A:
undetectable		 5mvmD-4fl0A:
13.47
5mvmE-4fl0A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga7 LEUKOCYTE ELASTASE
INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		5 ILE A 370
ALA A  12
ILE A  35
ILE A  30
ILE A 165
 None
 0.94A 5mvmD-4ga7A:
undetectable
5mvmE-4ga7A:
undetectable		 5mvmD-4ga7A:
12.27
5mvmE-4ga7A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kva SEPTIN

(Schistosoma
mansoni) 		PF00735
(Septin) 		5 ILE A 154
LEU A 161
ILE A 164
ALA A 168
TYR A 104
 None
 0.85A 5mvmD-4kvaA:
undetectable
5mvmE-4kvaA:
undetectable		 5mvmD-4kvaA:
11.60
5mvmE-4kvaA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		5 LEU A 355
ILE A 258
ALA A 261
ILE A 262
ILE A 310
 None
 0.98A 5mvmD-4oflA:
undetectable
5mvmE-4oflA:
undetectable		 5mvmD-4oflA:
7.94
5mvmE-4oflA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F

(Thermococcus
kodakarensis) 		PF03874
(RNA_pol_Rpb4) 		5 ILE F  95
LEU F  81
ILE F 112
ALA F 108
ILE F 111
 None
 0.99A 5mvmD-4qiwF:
undetectable
5mvmE-4qiwF:
undetectable		 5mvmD-4qiwF:
25.62
5mvmE-4qiwF:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgk UNCHARACTERIZED
PROTEIN

(Yersinia pestis) 		PF07350
(DUF1479) 		5 ALA A 300
LEU A 297
ILE A  10
ALA A  13
ILE A  14
 None
 1.01A 5mvmD-4rgkA:
undetectable
5mvmE-4rgkA:
undetectable		 5mvmD-4rgkA:
12.68
5mvmE-4rgkA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		5 ILE A 167
ALA A 164
LEU A 163
ALA A 131
ILE A 278
 None
 0.93A 5mvmD-4w1wA:
undetectable
5mvmE-4w1wA:
undetectable		 5mvmD-4w1wA:
10.78
5mvmE-4w1wA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		6 ILE A 188
LEU A 165
ILE A 157
ALA A 136
ILE A 137
ILE A 191
 None
 1.46A 5mvmD-4wnzA:
undetectable
5mvmE-4wnzA:
undetectable		 5mvmD-4wnzA:
14.13
5mvmE-4wnzA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnv P2Y PURINOCEPTOR 1,
RUBREDOXIN, P2Y
PURINOCEPTOR 1

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		5 ILE A 264
ALA A 327
ILE A 145
ILE A 233
TYR A 237
 None
 0.98A 5mvmD-4xnvA:
undetectable
5mvmE-4xnvA:
3.1		 5mvmD-4xnvA:
11.06
5mvmE-4xnvA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgk ACTIVE HELICASE

(Staphylococcus
aureus) 		PF06048
(DUF927) 		5 ILE A 516
LEU A 544
ILE A 445
ALA A 444
ILE A 448
 None
 1.02A 5mvmD-5dgkA:
undetectable
5mvmE-5dgkA:
2.5		 5mvmD-5dgkA:
10.28
5mvmE-5dgkA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9g ISOCITRATE LYASE

(Magnaporthe
oryzae) 		PF00463
(ICL) 		5 ALA A 423
ILE A 389
ALA A 392
ILE A 393
ILE A 402
 None
 0.99A 5mvmD-5e9gA:
undetectable
5mvmE-5e9gA:
undetectable		 5mvmD-5e9gA:
10.43
5mvmE-5e9gA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 ILE A 410
ALA A 412
LEU A 413
ILE A 457
ALA A 400
 None
 0.99A 5mvmD-5h7jA:
undetectable
5mvmE-5h7jA:
undetectable		 5mvmD-5h7jA:
21.11
5mvmE-5h7jA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihv BETA-LACTAMASE

(Burkholderia
ambifaria) 		PF13354
(Beta-lactamase2) 		5 ILE A  24
ALA A 237
LEU A 236
ALA A 197
ILE A 198
 None
 0.91A 5mvmD-5ihvA:
undetectable
5mvmE-5ihvA:
undetectable		 5mvmD-5ihvA:
18.27
5mvmE-5ihvA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imu TAT (TWIN-ARGININE
TRANSLOCATION)
PATHWAY SIGNAL
SEQUENCE CONTAINING
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 5 ILE A 382
ALA A 343
LEU A 346
ALA A 327
ILE A 324
 None
 0.97A 5mvmD-5imuA:
2.4
5mvmE-5imuA:
2.4		 5mvmD-5imuA:
17.83
5mvmE-5imuA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		5 ILE A 681
ILE A 801
ALA A 798
ILE A 797
TYR A 758
 None
 0.96A 5mvmD-5ksdA:
2.8
5mvmE-5ksdA:
2.7		 5mvmD-5ksdA:
7.61
5mvmE-5ksdA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF00483
(NTP_transferase) 		5 ILE A 215
ALA A 140
ILE A  24
ALA A  22
ILE A  66
 None
 0.94A 5mvmD-5l6sA:
undetectable
5mvmE-5l6sA:
undetectable		 5mvmD-5l6sA:
12.02
5mvmE-5l6sA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Bos taurus) 		PF00346
(Complex1_49kDa)
PF00361
(Proton_antipo_M)
PF06444
(NADH_dehy_S2_C) 		5 ILE N 244
ILE d  44
ALA d  47
ILE d  48
ILE N 239
 None
 1.03A 5mvmD-5lc5N:
undetectable
5mvmE-5lc5N:
undetectable		 5mvmD-5lc5N:
11.71
5mvmE-5lc5N:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn HEXON PROTEIN,HEXON
CAPSID

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 ILE A 935
LEU A 347
ALA A 567
ILE A 568
TYR A 939
 None
 1.00A 5mvmD-5ldnA:
undetectable
5mvmE-5ldnA:
undetectable		 5mvmD-5ldnA:
7.35
5mvmE-5ldnA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfi LACTOCOCCIN-A
IMMUNITY PROTEIN

(Lactococcus
lactis) 		PF08951
(EntA_Immun) 		5 ALA A  38
LEU A  39
ALA A  54
GLU A  55
ILE A  67
 None
 1.00A 5mvmD-5lfiA:
undetectable
5mvmE-5lfiA:
undetectable		 5mvmD-5lfiA:
17.65
5mvmE-5lfiA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkf POLYCYSTIN-2

(Homo sapiens) 		PF08016
(PKD_channel) 		5 ILE A 526
ALA A 474
ILE A 478
GLU A 477
TYR A 465
 None
 1.02A 5mvmD-5mkfA:
4.4
5mvmE-5mkfA:
4.7		 5mvmD-5mkfA:
6.26
5mvmE-5mkfA:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp2 TYPE II SECRETION
SYSTEM PROTEIN D

(Pseudomonas
aeruginosa) 		no annotation 5 ILE A 160
LEU A 182
ILE A 194
ILE A 198
ILE A 244
 None
 1.03A 5mvmD-5mp2A:
undetectable
5mvmE-5mp2A:
undetectable		 5mvmD-5mp2A:
22.34
5mvmE-5mp2A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 5 ILE A 569
ALA A 599
LEU A 593
ALA A 604
ILE A 605
 None
 1.01A 5mvmD-5n94A:
undetectable
5mvmE-5n94A:
undetectable		 5mvmD-5n94A:
20.93
5mvmE-5n94A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE

(Trypanosoma
brucei) 		no annotation 5 ILE A 437
ALA A 439
ALA A 524
ILE A 525
ILE A 542
 None
DMS  A 805 ( 4.2A)
None
None
None
 0.95A 5mvmD-5nfhA:
5.5
5mvmE-5nfhA:
5.5		 5mvmD-5nfhA:
9.30
5mvmE-5nfhA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0i 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8

(Homo sapiens) 		PF00004
(AAA) 		5 ALA d 194
LEU d 198
ILE d 182
ALA d 179
ILE d 178
 None
 0.98A 5mvmD-5t0id:
3.1
5mvmE-5t0id:
undetectable		 5mvmD-5t0id:
12.50
5mvmE-5t0id:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 ILE A1663
ILE A1757
ALA A1760
ILE A1761
ILE A1812
 None
 1.01A 5mvmD-5t8vA:
4.2
5mvmE-5t8vA:
5.6		 5mvmD-5t8vA:
4.09
5mvmE-5t8vA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u56 MACROPHAGE GROWTH
LOCUS A
STRINGENT STARVATION
PROTEIN A

(Francisella
tularensis) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 LEU A  19
ILE A  68
ALA A  71
ILE A  72
ILE C  89
 None
 0.85A 5mvmD-5u56A:
3.1
5mvmE-5u56A:
2.7		 5mvmD-5u56A:
17.68
5mvmE-5u56A:
17.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 5 ILE C 236
ILE C 240
GLU C 243
ILE C 259
TYR C 263
 LMT  C 401 ( 4.5A)
LMT  C 401 (-3.9A)
None
None
None
 0.43A 5mvmD-5v6nC:
36.2
5mvmE-5v6nC:
36.2		 5mvmD-5v6nC:
97.26
5mvmE-5v6nC:
97.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2

(Leptotrichia
shahii) 		no annotation 5 ILE A 842
LEU A 845
ILE A 852
ILE A 881
ILE A 874
 None
 1.03A 5mvmD-5wtkA:
undetectable
5mvmE-5wtkA:
4.1		 5mvmD-5wtkA:
4.06
5mvmE-5wtkA:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E

(Staphylococcus
aureus) 		no annotation 5 ILE A 288
LEU A 265
ILE A 124
ILE A 139
ILE A 132
 None
 0.88A 5mvmD-5xoeA:
undetectable
5mvmE-5xoeA:
undetectable		 5mvmD-5xoeA:
25.61
5mvmE-5xoeA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES

(Staphylococcus
aureus) 		no annotation 5 LEU A 394
ILE A 351
ALA A 354
ILE A 355
ILE A 340
 None
 0.97A 5mvmD-5xt3A:
undetectable
5mvmE-5xt3A:
undetectable		 5mvmD-5xt3A:
18.68
5mvmE-5xt3A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a31 PEPTIDYL-TRNA
HYDROLASE

(Acinetobacter
baumannii) 		no annotation 5 ILE A   7
LEU A  32
ILE A 165
ALA A 168
ILE A 187
 None
 0.93A 5mvmD-6a31A:
undetectable
5mvmE-6a31A:
undetectable		 5mvmD-6a31A:
23.40
5mvmE-6a31A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aon DIHYDROLIPOYL
DEHYDROGENASE

(Bordetella
pertussis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 444
ALA A 434
ILE A 437
GLU A 433
ILE A 431
 None
 0.93A 5mvmD-6aonA:
undetectable
5mvmE-6aonA:
undetectable		 5mvmD-6aonA:
10.48
5mvmE-6aonA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 5 ALA A 200
ILE A 165
ALA A 168
ILE A 169
ILE A 230
 None
 0.99A 5mvmD-6at7A:
undetectable
5mvmE-6at7A:
undetectable		 5mvmD-6at7A:
26.19
5mvmE-6at7A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA

(Homo sapiens) 		no annotation 5 ILE A 309
ILE A 223
ALA A 221
ILE A 222
ILE A 332
 None
 0.93A 5mvmD-6g79A:
undetectable
5mvmE-6g79A:
undetectable		 5mvmD-6g79A:
17.86
5mvmE-6g79A:
17.86