SIMILAR PATTERNS OF AMINO ACIDS FOR 5MVM_B_PFLB510_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea) 		PF01070
(FMN_dh) 		4 ILE A 266
ALA A 297
LEU A 300
ILE A 354
 None
 0.71A 5mvmB-1al8A:
undetectable
5mvmC-1al8A:
0.0		 5mvmB-1al8A:
13.76
5mvmC-1al8A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axn ANNEXIN III

(Homo sapiens) 		PF00191
(Annexin) 		4 ILE A 225
ALA A 180
LEU A 183
ILE A 201
 None
 0.81A 5mvmB-1axnA:
1.4
5mvmC-1axnA:
1.4		 5mvmB-1axnA:
15.19
5mvmC-1axnA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE

(Bacillus
subtilis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 ILE A 195
MET A 208
ALA A 238
LEU A 239
ILE A 214
 None
 1.06A 5mvmB-1dkrA:
undetectable
5mvmC-1dkrA:
0.0		 5mvmB-1dkrA:
14.06
5mvmC-1dkrA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases) 		4 ILE B 449
ALA B 239
LEU B 240
ILE B 443
 None
 0.78A 5mvmB-1e3dB:
undetectable
5mvmC-1e3dB:
undetectable		 5mvmB-1e3dB:
10.52
5mvmC-1e3dB:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 ILE A 367
ALA A 342
LEU A 345
ILE A 390
 None
 0.69A 5mvmB-1fc4A:
0.0
5mvmC-1fc4A:
0.0		 5mvmB-1fc4A:
11.50
5mvmC-1fc4A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5g FUSION PROTEIN

(Avian
avulavirus 1) 		PF00523
(Fusion_gly) 		4 ILE A 235
ALA A 237
LEU A 238
ILE A 269
 None
 0.86A 5mvmB-1g5gA:
undetectable
5mvmC-1g5gA:
undetectable		 5mvmB-1g5gA:
10.04
5mvmC-1g5gA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		4 ALA A 415
LEU A 412
ILE A 257
TYR A 370
 None
 0.88A 5mvmB-1gz5A:
0.0
5mvmC-1gz5A:
0.0		 5mvmB-1gz5A:
11.97
5mvmC-1gz5A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2w BETA-LACTAMASE

(Bacillus
licheniformis) 		PF13354
(Beta-lactamase2) 		4 ILE A  46
ALA A 262
LEU A 261
ILE A 221
 None
 0.67A 5mvmB-1i2wA:
0.1
5mvmC-1i2wA:
0.0		 5mvmB-1i2wA:
16.19
5mvmC-1i2wA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		4 ILE A 222
ALA A 292
LEU A 295
ILE A 244
 None
 0.87A 5mvmB-1j1uA:
0.0
5mvmC-1j1uA:
undetectable		 5mvmB-1j1uA:
16.53
5mvmC-1j1uA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 ALA A 423
LEU A 422
ILE A 456
TYR A 500
 None
 0.77A 5mvmB-1ldjA:
3.3
5mvmC-1ldjA:
3.1		 5mvmB-1ldjA:
8.44
5mvmC-1ldjA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		4 ILE A 378
ALA A 375
LEU A 371
ILE A 466
 None
 0.86A 5mvmB-1lrtA:
undetectable
5mvmC-1lrtA:
undetectable		 5mvmB-1lrtA:
11.90
5mvmC-1lrtA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ILE A 378
ALA A 375
LEU A 371
ILE A 466
 None
 0.88A 5mvmB-1mewA:
undetectable
5mvmC-1mewA:
undetectable		 5mvmB-1mewA:
9.87
5mvmC-1mewA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n47 ISOLECTIN B4

(Vicia villosa) 		PF00139
(Lectin_legB) 		4 ILE A 165
ALA A 175
LEU A 174
ILE A 140
 None
 0.82A 5mvmB-1n47A:
undetectable
5mvmC-1n47A:
undetectable		 5mvmB-1n47A:
15.67
5mvmC-1n47A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvp TRANSCRIPTION
INITIATION FACTOR
IIA BETA CHAIN
TRANSCRIPTION
INITIATION FACTOR
IIA GAMMA CHAIN

(Homo sapiens) 		PF02268
(TFIIA_gamma_N)
PF02751
(TFIIA_gamma_C)
PF03153
(TFIIA) 		4 ILE D  44
ALA D  47
LEU D  48
ILE C 366
 None
 0.84A 5mvmB-1nvpD:
undetectable
5mvmC-1nvpD:
undetectable		 5mvmB-1nvpD:
25.23
5mvmC-1nvpD:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odt CEPHALOSPORIN C
DEACETYLASE

(Bacillus
subtilis) 		PF05448
(AXE1) 		4 MET C 115
ALA C 160
LEU C 161
ILE C 175
 None
 0.75A 5mvmB-1odtC:
undetectable
5mvmC-1odtC:
undetectable		 5mvmB-1odtC:
14.79
5mvmC-1odtC:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
DELTA CHAIN

(Torpedo
marmorata) 		PF02932
(Neur_chan_memb) 		4 ILE C 303
ALA C 268
LEU C 271
ILE C 239
 None
 0.80A 5mvmB-1oedC:
9.8
5mvmC-1oedC:
9.7		 5mvmB-1oedC:
16.96
5mvmC-1oedC:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE

(Pyrococcus
furiosus) 		PF03070
(TENA_THI-4) 		4 ALA A  50
LEU A  51
ILE A  73
TYR A 164
 MP5  A1213 (-3.6A)
None
None
None
 0.86A 5mvmB-1rtwA:
4.0
5mvmC-1rtwA:
4.0		 5mvmB-1rtwA:
17.54
5mvmC-1rtwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t57 CONSERVED PROTEIN
MTH1675

(Methanothermobacter
thermautotrophicus) 		PF02887
(PK_C) 		4 ILE A  56
ALA A  45
LEU A  48
ILE A 151
 None
 0.68A 5mvmB-1t57A:
undetectable
5mvmC-1t57A:
undetectable		 5mvmB-1t57A:
17.50
5mvmC-1t57A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tiq PROTEASE SYNTHASE
AND SPORULATION
NEGATIVE REGULATORY
PROTEIN PAI 1

(Bacillus
subtilis) 		PF00583
(Acetyltransf_1) 		4 ILE A 116
ALA A 119
LEU A 120
ILE A 172
 None
 0.86A 5mvmB-1tiqA:
undetectable
5mvmC-1tiqA:
undetectable		 5mvmB-1tiqA:
19.21
5mvmC-1tiqA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 272
ALA A 204
LEU A 207
ILE A 114
 None
 0.63A 5mvmB-1ua2A:
undetectable
5mvmC-1ua2A:
undetectable		 5mvmB-1ua2A:
14.09
5mvmC-1ua2A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		4 ILE A 428
ALA A 370
ILE A 438
TYR A 347
 AMP  A1456 (-3.9A)
None
AMP  A1456 (-3.1A)
AMP  A1456 (-4.8A)
 0.79A 5mvmB-1ua4A:
undetectable
5mvmC-1ua4A:
undetectable		 5mvmB-1ua4A:
9.67
5mvmC-1ua4A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud3 AMYLASE

(Bacillus sp.
KSM-K38) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 ILE A  37
ALA A  35
LEU A 385
ILE A 381
TYR A 367
 None
 1.33A 5mvmB-1ud3A:
undetectable
5mvmC-1ud3A:
undetectable		 5mvmB-1ud3A:
9.33
5mvmC-1ud3A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Pyrococcus
horikoshii) 		PF08282
(Hydrolase_3) 		4 ILE A  37
ALA A 184
LEU A 187
ILE A  68
 None
 0.87A 5mvmB-1wzcA:
undetectable
5mvmC-1wzcA:
undetectable		 5mvmB-1wzcA:
14.06
5mvmC-1wzcA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfk FORMIMIDOYLGLUTAMASE

(Vibrio cholerae) 		PF00491
(Arginase) 		4 ILE A 322
MET A 326
LEU A 251
ILE A 286
 None
 0.64A 5mvmB-1xfkA:
undetectable
5mvmC-1xfkA:
undetectable		 5mvmB-1xfkA:
13.25
5mvmC-1xfkA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqw PROLINE
IMINOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00561
(Abhydrolase_1) 		4 ILE A 225
ALA A 109
LEU A 112
ILE A 254
 None
 0.73A 5mvmB-1xqwA:
undetectable
5mvmC-1xqwA:
undetectable		 5mvmB-1xqwA:
11.70
5mvmC-1xqwA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ILE A 873
ALA A 858
LEU A 861
ILE A 705
TYR A 714
 None
 1.23A 5mvmB-2b49A:
undetectable
5mvmC-2b49A:
undetectable		 5mvmB-2b49A:
14.03
5mvmC-2b49A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea) 		PF00246
(Peptidase_M14) 		4 ILE A  18
LEU A  22
ILE A  83
TYR A   9
 None
 0.80A 5mvmB-2c1cA:
undetectable
5mvmC-2c1cA:
undetectable		 5mvmB-2c1cA:
12.62
5mvmC-2c1cA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eax PEPTIDOGLYCAN
RECOGNITION
PROTEIN-I-BETA

(Homo sapiens) 		PF01510
(Amidase_2) 		4 ILE A 307
ALA A 326
LEU A 329
ILE A 284
 None
 0.64A 5mvmB-2eaxA:
undetectable
5mvmC-2eaxA:
undetectable		 5mvmB-2eaxA:
18.29
5mvmC-2eaxA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i75 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ILE A 883
ALA A 868
LEU A 871
ILE A 714
TYR A 723
 None
 1.01A 5mvmB-2i75A:
undetectable
5mvmC-2i75A:
undetectable		 5mvmB-2i75A:
11.99
5mvmC-2i75A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jvf DE NOVO PROTEIN M7

(unidentified) 		no annotation 4 ILE A  77
ALA A  66
LEU A  69
ILE A  48
 None
 0.86A 5mvmB-2jvfA:
undetectable
5mvmC-2jvfA:
undetectable		 5mvmB-2jvfA:
25.74
5mvmC-2jvfA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o08 BH1327 PROTEIN

(Bacillus
halodurans) 		PF01966
(HD) 		4 ILE A  48
ALA A  46
LEU A  45
ILE A  97
 None
 0.87A 5mvmB-2o08A:
undetectable
5mvmC-2o08A:
undetectable		 5mvmB-2o08A:
18.78
5mvmC-2o08A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8r POLYPHOSPHATE KINASE

(Porphyromonas
gingivalis) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		4 ILE A 384
ALA A 387
LEU A 388
ILE A 371
 None
 0.87A 5mvmB-2o8rA:
4.6
5mvmC-2o8rA:
3.5		 5mvmB-2o8rA:
8.10
5mvmC-2o8rA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		4 ILE A  32
ALA A 173
LEU A 174
ILE A 180
 None
 0.86A 5mvmB-2ppvA:
undetectable
5mvmC-2ppvA:
undetectable		 5mvmB-2ppvA:
13.15
5mvmC-2ppvA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ran ANNEXIN V

(Rattus
norvegicus) 		PF00191
(Annexin) 		4 ILE A 219
ALA A 174
LEU A 177
ILE A 195
 None
 0.85A 5mvmB-2ranA:
undetectable
5mvmC-2ranA:
undetectable		 5mvmB-2ranA:
12.50
5mvmC-2ranA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22)
PF01163
(RIO1) 		4 ILE A  71
ALA A  90
LEU A  93
ILE A  56
 None
 0.88A 5mvmB-2vwbA:
2.2
5mvmC-2vwbA:
undetectable		 5mvmB-2vwbA:
9.96
5mvmC-2vwbA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zl3 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Helicobacter
pylori) 		PF00574
(CLP_protease) 		4 ILE A 121
ALA A 102
LEU A 105
ILE A  65
 None
 0.86A 5mvmB-2zl3A:
undetectable
5mvmC-2zl3A:
undetectable		 5mvmB-2zl3A:
14.36
5mvmC-2zl3A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE

(Bacillus virus
NIT1) 		PF05908
(Gamma_PGA_hydro) 		4 ILE A 152
ALA A  89
LEU A  93
ILE A  35
 None
 0.86A 5mvmB-3a9lA:
undetectable
5mvmC-3a9lA:
undetectable		 5mvmB-3a9lA:
18.27
5mvmC-3a9lA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6e INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF04851
(ResIII) 		4 ILE A 457
ALA A 414
LEU A 417
ILE A 360
 None
 0.86A 5mvmB-3b6eA:
undetectable
5mvmC-3b6eA:
undetectable		 5mvmB-3b6eA:
22.94
5mvmC-3b6eA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8a HEXOKINASE-1

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ILE X 196
ALA X 132
LEU X 135
ILE X  85
 None
 0.80A 5mvmB-3b8aX:
undetectable
5mvmC-3b8aX:
undetectable		 5mvmB-3b8aX:
10.55
5mvmC-3b8aX:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN ALPHA
CHAIN
FIBRINOGEN BETA
CHAIN
FIBRINOGEN GAMMA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 ILE A 154
LEU C 124
ILE B 179
TYR A 178
 None
 0.72A 5mvmB-3bvhA:
3.9
5mvmC-3bvhA:
3.9		 5mvmB-3bvhA:
21.52
5mvmC-3bvhA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cax UNCHARACTERIZED
PROTEIN PF0695

(Pyrococcus
furiosus) 		PF01814
(Hemerythrin)
PF13596
(PAS_10) 		4 ALA A 139
LEU A 142
ILE A 168
TYR A 284
 None
 0.69A 5mvmB-3caxA:
4.5
5mvmC-3caxA:
4.5		 5mvmB-3caxA:
13.13
5mvmC-3caxA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cio TYROSINE-PROTEIN
KINASE ETK

(Escherichia
coli) 		PF13614
(AAA_31) 		5 ILE A 566
ALA A 637
LEU A 564
ILE A 601
TYR A 590
 None
 1.43A 5mvmB-3cioA:
undetectable
5mvmC-3cioA:
undetectable		 5mvmB-3cioA:
15.26
5mvmC-3cioA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dby UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		4 ILE A  92
ALA A  33
LEU A  32
ILE A  40
 None
 0.81A 5mvmB-3dbyA:
5.6
5mvmC-3dbyA:
5.4		 5mvmB-3dbyA:
11.97
5mvmC-3dbyA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnd CHITINASE

(Bacteroides
thetaiotaomicron) 		PF00704
(Glyco_hydro_18) 		4 ILE A 154
ALA A 173
LEU A 176
ILE A 137
 None
 0.85A 5mvmB-3fndA:
undetectable
5mvmC-3fndA:
undetectable		 5mvmB-3fndA:
14.72
5mvmC-3fndA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		4 ILE A  81
ALA A  50
LEU A  53
ILE A  97
 None
 0.69A 5mvmB-3hc1A:
undetectable
5mvmC-3hc1A:
undetectable		 5mvmB-3hc1A:
15.41
5mvmC-3hc1A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv2 RESPONSE
REGULATOR/HD DOMAIN
PROTEIN

(Pseudomonas
protegens) 		PF00072
(Response_reg) 		4 ILE A  24
ALA A  63
LEU A  90
ILE A  61
 None
SO4  A 152 (-3.2A)
None
None
 0.77A 5mvmB-3hv2A:
undetectable
5mvmC-3hv2A:
undetectable		 5mvmB-3hv2A:
16.11
5mvmC-3hv2A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i83 2-DEHYDROPANTOATE
2-REDUCTASE

(Methylococcus
capsulatus) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 ILE A   6
ALA A  92
LEU A  89
ILE A  99
 None
 0.76A 5mvmB-3i83A:
undetectable
5mvmC-3i83A:
undetectable		 5mvmB-3i83A:
13.82
5mvmC-3i83A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipo PUTATIVE THIOSULFATE
SULFURTRANSFERASE
YNJE

(Escherichia
coli) 		PF00581
(Rhodanese) 		4 ILE A 123
ALA A  27
LEU A  26
ILE A 125
 None
 0.80A 5mvmB-3ipoA:
undetectable
5mvmC-3ipoA:
undetectable		 5mvmB-3ipoA:
14.56
5mvmC-3ipoA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF4

(Schizosaccharomyces
pombe) 		PF02184
(HAT) 		4 ILE R 111
MET R 115
ALA R 123
LEU R 126
 None
 0.74A 5mvmB-3jb9R:
1.6
5mvmC-3jb9R:
undetectable		 5mvmB-3jb9R:
17.29
5mvmC-3jb9R:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 263
ALA A 304
LEU A 307
ILE A 271
 None
 0.74A 5mvmB-3kumA:
undetectable
5mvmC-3kumA:
undetectable		 5mvmB-3kumA:
16.79
5mvmC-3kumA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l39 PUTATIVE PHOU-LIKE
PHOSPHATE REGULATORY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01865
(PhoU_div) 		4 ILE A  84
ALA A  88
LEU A  87
ILE A 206
 None
 0.87A 5mvmB-3l39A:
7.7
5mvmC-3l39A:
7.7		 5mvmB-3l39A:
16.36
5mvmC-3l39A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lho PUTATIVE HYDROLASE

(Shewanella
frigidimarina) 		PF07063
(DUF1338) 		4 ILE A  79
LEU A  53
ILE A  95
TYR A 151
 None
 0.83A 5mvmB-3lhoA:
undetectable
5mvmC-3lhoA:
undetectable		 5mvmB-3lhoA:
15.53
5mvmC-3lhoA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ILE A 219
ALA A 224
LEU A 227
ILE A 374
 None
 0.74A 5mvmB-3mcxA:
2.2
5mvmC-3mcxA:
2.2		 5mvmB-3mcxA:
10.62
5mvmC-3mcxA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 ILE A  23
ALA A  30
LEU A  29
ILE A  32
 None
 0.83A 5mvmB-3mduA:
undetectable
5mvmC-3mduA:
undetectable		 5mvmB-3mduA:
12.01
5mvmC-3mduA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		4 MET A 230
ALA A 196
LEU A 199
ILE A 223
 None
 0.84A 5mvmB-3mx3A:
2.6
5mvmC-3mx3A:
2.9		 5mvmB-3mx3A:
10.14
5mvmC-3mx3A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o10 SACSIN

(Homo sapiens) 		PF05168
(HEPN) 		4 ILE A4567
ALA A4484
LEU A4485
ILE A4509
 None
 0.65A 5mvmB-3o10A:
2.1
5mvmC-3o10A:
2.9		 5mvmB-3o10A:
20.00
5mvmC-3o10A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of5 DETHIOBIOTIN
SYNTHETASE

(Francisella
tularensis) 		PF13500
(AAA_26) 		5 ILE A 133
ALA A 135
LEU A 136
ILE A 100
TYR A 123
 None
 1.38A 5mvmB-3of5A:
undetectable
5mvmC-3of5A:
undetectable		 5mvmB-3of5A:
19.67
5mvmC-3of5A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oji ABSCISIC ACID
RECEPTOR PYL3

(Arabidopsis
thaliana) 		PF10604
(Polyketide_cyc2) 		4 ILE A 203
ALA A 201
LEU A 200
ILE A  65
 None
 0.86A 5mvmB-3ojiA:
undetectable
5mvmC-3ojiA:
undetectable		 5mvmB-3ojiA:
20.23
5mvmC-3ojiA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olq UNIVERSAL STRESS
PROTEIN E

(Proteus
mirabilis) 		PF00582
(Usp) 		4 ILE A  11
ALA A  20
LEU A  21
ILE A  35
 None
None
UNL  A 321 ( 4.7A)
None
 0.61A 5mvmB-3olqA:
undetectable
5mvmC-3olqA:
undetectable		 5mvmB-3olqA:
16.54
5mvmC-3olqA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 ILE A 184
ALA A 249
LEU A 252
ILE A 246
 None
 0.87A 5mvmB-3oukA:
undetectable
5mvmC-3oukA:
undetectable		 5mvmB-3oukA:
17.51
5mvmC-3oukA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3v PTS SYSTEM,
N-ACETYLGALACTOSAMIN
E-SPECIFIC IIB
COMPONENT

(Streptococcus
pyogenes) 		PF03830
(PTSIIB_sorb) 		4 ILE A  82
ALA A  90
LEU A  93
ILE A  64
 None
 0.83A 5mvmB-3p3vA:
undetectable
5mvmC-3p3vA:
undetectable		 5mvmB-3p3vA:
17.37
5mvmC-3p3vA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdk PHOSPHOGLUCOSAMINE
MUTASE

(Bacillus
anthracis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ILE A 235
ALA A 345
LEU A 348
ILE A 261
 None
 0.78A 5mvmB-3pdkA:
undetectable
5mvmC-3pdkA:
undetectable		 5mvmB-3pdkA:
11.59
5mvmC-3pdkA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwt PUTATIVE GH105
FAMILY PROTEIN

(Salmonella
enterica) 		PF07470
(Glyco_hydro_88) 		4 ILE A 329
ALA A 366
LEU A 370
ILE A 322
 None
 0.87A 5mvmB-3qwtA:
undetectable
5mvmC-3qwtA:
undetectable		 5mvmB-3qwtA:
12.34
5mvmC-3qwtA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxb PUTATIVE XYLOSE
ISOMERASE

(Rhodospirillum
rubrum) 		PF01261
(AP_endonuc_2) 		4 ALA A 111
LEU A 153
ILE A 101
TYR A  37
 None
 0.86A 5mvmB-3qxbA:
undetectable
5mvmC-3qxbA:
undetectable		 5mvmB-3qxbA:
14.05
5mvmC-3qxbA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcc SORTASE SRTA

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		5 ILE A  76
MET A 141
ALA A 137
LEU A 134
ILE A 193
 None
 1.47A 5mvmB-3rccA:
undetectable
5mvmC-3rccA:
undetectable		 5mvmB-3rccA:
17.50
5mvmC-3rccA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhd LACTALDEHYDE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00171
(Aldedh) 		4 MET A  14
ALA A  30
LEU A  31
ILE A   9
 None
 0.87A 5mvmB-3rhdA:
undetectable
5mvmC-3rhdA:
undetectable		 5mvmB-3rhdA:
12.06
5mvmC-3rhdA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN

(Legionella
pneumophila) 		PF13407
(Peripla_BP_4) 		4 ILE A  73
ALA A  76
LEU A  77
ILE A 106
 None
 0.79A 5mvmB-3rotA:
undetectable
5mvmC-3rotA:
undetectable		 5mvmB-3rotA:
17.47
5mvmC-3rotA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)

(Sulfolobus
solfataricus) 		PF01048
(PNP_UDP_1) 		4 ILE A 209
ALA A 239
LEU A 242
ILE A 154
 None
 0.63A 5mvmB-3t94A:
undetectable
5mvmC-3t94A:
undetectable		 5mvmB-3t94A:
20.50
5mvmC-3t94A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u66 PUTATIVE TYPE VI
SECRETION PROTEIN

(Escherichia
coli) 		PF09850
(DotU) 		5 ILE A 152
ALA A 154
LEU A 155
ILE A 111
TYR A 140
 None
 1.45A 5mvmB-3u66A:
3.5
5mvmC-3u66A:
3.5		 5mvmB-3u66A:
18.56
5mvmC-3u66A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 ILE B  89
ALA B 219
LEU B 222
ILE B  82
 None
 0.85A 5mvmB-3v0aB:
4.6
5mvmC-3v0aB:
4.7		 5mvmB-3v0aB:
5.53
5mvmC-3v0aB:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		4 ILE A 397
ALA A 115
LEU A 134
ILE A 108
 None
 0.83A 5mvmB-3v7pA:
undetectable
5mvmC-3v7pA:
undetectable		 5mvmB-3v7pA:
10.77
5mvmC-3v7pA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuo NTNHA

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 ILE A  89
ALA A 219
LEU A 222
ILE A  82
 None
 0.83A 5mvmB-3vuoA:
4.1
5mvmC-3vuoA:
5.3		 5mvmB-3vuoA:
5.36
5mvmC-3vuoA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs7 PYRIDOXAL KINASE

(Trypanosoma
brucei) 		PF08543
(Phos_pyr_kin) 		4 ILE A 115
ALA A 232
LEU A 235
ILE A 183
 None
 0.77A 5mvmB-3zs7A:
undetectable
5mvmC-3zs7A:
undetectable		 5mvmB-3zs7A:
18.18
5mvmC-3zs7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 ILE A 109
MET A 113
ALA A 181
LEU A 184
 None
 0.85A 5mvmB-4a2wA:
3.2
5mvmC-4a2wA:
3.1		 5mvmB-4a2wA:
6.43
5mvmC-4a2wA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ade SUCCINYLORNITHINE
TRANSAMINASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 ILE A 221
ALA A 116
LEU A 113
ILE A 131
 None
 0.87A 5mvmB-4adeA:
undetectable
5mvmC-4adeA:
undetectable		 5mvmB-4adeA:
15.62
5mvmC-4adeA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE

(Thermococcus
litoralis) 		PF04587
(ADP_PFK_GK) 		4 ILE A 439
ALA A 380
ILE A 449
TYR A 357
 AMP  A1472 ( 4.3A)
None
AMP  A1472 (-3.7A)
None
 0.76A 5mvmB-4b8sA:
undetectable
5mvmC-4b8sA:
undetectable		 5mvmB-4b8sA:
8.87
5mvmC-4b8sA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		4 ILE A 362
ALA A 329
LEU A 332
ILE A 325
 None
 0.86A 5mvmB-4bhdA:
undetectable
5mvmC-4bhdA:
undetectable		 5mvmB-4bhdA:
13.03
5mvmC-4bhdA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c75 BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		4 ILE A 259
ALA A 287
LEU A 290
ILE A  57
 None
 0.81A 5mvmB-4c75A:
undetectable
5mvmC-4c75A:
undetectable		 5mvmB-4c75A:
17.24
5mvmC-4c75A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu2 ENDOLYSIN

(Clostridium
phage phiCTP1) 		no annotation 4 ALA A 210
LEU A 213
ILE A 254
TYR A 246
 None
 0.86A 5mvmB-4cu2A:
undetectable
5mvmC-4cu2A:
undetectable		 5mvmB-4cu2A:
14.46
5mvmC-4cu2A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2i HERA

(Sulfolobus
solfataricus) 		PF01935
(DUF87)
PF05872
(DUF853)
PF09378
(HAS-barrel) 		4 ILE A 422
ALA A 434
LEU A 437
ILE A 446
 None
 0.82A 5mvmB-4d2iA:
undetectable
5mvmC-4d2iA:
undetectable		 5mvmB-4d2iA:
11.16
5mvmC-4d2iA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dp0 PLASTOCYANIN B,
CHLOROPLASTIC

(Populus nigra) 		PF00127
(Copper-bind) 		4 ILE X  27
ALA X  73
LEU X  74
ILE X  55
 None
 0.66A 5mvmB-4dp0X:
undetectable
5mvmC-4dp0X:
undetectable		 5mvmB-4dp0X:
22.52
5mvmC-4dp0X:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpc PLASTOCYANIN A,
CHLOROPLASTIC

(Populus nigra) 		PF00127
(Copper-bind) 		4 ILE X  27
ALA X  73
LEU X  74
ILE X  55
 None
 0.74A 5mvmB-4dpcX:
undetectable
5mvmC-4dpcX:
undetectable		 5mvmB-4dpcX:
25.23
5mvmC-4dpcX:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb5 PROBABLE CYSTEINE
DESULFURASE 2

(Archaeoglobus
fulgidus) 		PF00266
(Aminotran_5) 		4 ILE A  91
ALA A 105
LEU A 108
ILE A  78
 None
None
None
GOL  A 403 ( 4.7A)
 0.79A 5mvmB-4eb5A:
undetectable
5mvmC-4eb5A:
undetectable		 5mvmB-4eb5A:
14.68
5mvmC-4eb5A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8i HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF16227
(DUF4886) 		5 ILE A 106
MET A  66
ALA A 109
LEU A 110
ILE A 118
 None
 1.36A 5mvmB-4i8iA:
undetectable
5mvmC-4i8iA:
undetectable		 5mvmB-4i8iA:
14.44
5mvmC-4i8iA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1

(Arabidopsis
thaliana) 		PF01399
(PCI)
PF10602
(RPN7) 		4 ILE A 187
ALA A 220
LEU A 223
ILE A 253
 None
 0.82A 5mvmB-4lctA:
2.9
5mvmC-4lctA:
2.8		 5mvmB-4lctA:
16.05
5mvmC-4lctA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING

(Bacteroides
vulgatus) 		PF12771
(SusD-like_2) 		4 MET A 227
ALA A 193
LEU A 196
ILE A 220
 None
 0.82A 5mvmB-4lerA:
2.5
5mvmC-4lerA:
2.5		 5mvmB-4lerA:
11.34
5mvmC-4lerA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfitobacterium
hafniense) 		PF13458
(Peripla_BP_6) 		4 ILE A 168
ALA A 131
LEU A 134
ILE A 225
 None
 0.81A 5mvmB-4mlcA:
undetectable
5mvmC-4mlcA:
undetectable		 5mvmB-4mlcA:
11.90
5mvmC-4mlcA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 MET A 898
ALA A 896
LEU A 895
ILE A 875
TYR A 806
 None
 1.14A 5mvmB-4nmeA:
undetectable
5mvmC-4nmeA:
undetectable		 5mvmB-4nmeA:
5.65
5mvmC-4nmeA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv7 ARYLAMINE
N-ACETYLTRANSFERASE

(Mesorhizobium
japonicum) 		PF00797
(Acetyltransf_2) 		4 ILE A 273
ALA A 243
LEU A 246
ILE A 240
 None
 0.80A 5mvmB-4nv7A:
undetectable
5mvmC-4nv7A:
undetectable		 5mvmB-4nv7A:
14.74
5mvmC-4nv7A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA

(Staphylococcus
pseudintermedius) 		PF01297
(ZnuA) 		4 ILE A  56
ALA A  75
LEU A  76
ILE A  82
 None
 0.82A 5mvmB-4oxrA:
undetectable
5mvmC-4oxrA:
undetectable		 5mvmB-4oxrA:
17.94
5mvmC-4oxrA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9t NUCLEOPORIN NUP133

(Vanderwaltozyma
polyspora) 		PF08801
(Nucleoporin_N) 		5 ILE A 381
ALA A 368
LEU A 379
ILE A 370
TYR A 330
 None
 1.33A 5mvmB-4q9tA:
undetectable
5mvmC-4q9tA:
undetectable		 5mvmB-4q9tA:
11.39
5mvmC-4q9tA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk0 LACI FAMILY
SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecalis) 		PF13377
(Peripla_BP_3) 		4 ILE A  72
ALA A 303
LEU A 306
ILE A 153
 None
 0.84A 5mvmB-4rk0A:
undetectable
5mvmC-4rk0A:
undetectable		 5mvmB-4rk0A:
16.67
5mvmC-4rk0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecium) 		PF13377
(Peripla_BP_3) 		4 ILE A  69
ALA A 306
LEU A 309
ILE A 150
 None
 0.84A 5mvmB-4rk1A:
undetectable
5mvmC-4rk1A:
undetectable		 5mvmB-4rk1A:
11.96
5mvmC-4rk1A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm9 EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 ILE A 110
ALA A 122
LEU A 125
ILE A 194
 None
 0.88A 5mvmB-4rm9A:
undetectable
5mvmC-4rm9A:
undetectable		 5mvmB-4rm9A:
9.20
5mvmC-4rm9A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 ILE A  94
ALA A 282
LEU A 279
ILE A  64
 None
 0.85A 5mvmB-4rs3A:
undetectable
5mvmC-4rs3A:
undetectable		 5mvmB-4rs3A:
12.99
5mvmC-4rs3A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 4 ILE A 497
ALA A 474
LEU A 473
TYR A 201
 None
 0.82A 5mvmB-4tz5A:
undetectable
5mvmC-4tz5A:
undetectable		 5mvmB-4tz5A:
9.90
5mvmC-4tz5A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 ILE L 459
ALA L 249
LEU L 250
ILE L 452
 None
 0.77A 5mvmB-4u9iL:
undetectable
5mvmC-4u9iL:
undetectable		 5mvmB-4u9iL:
8.63
5mvmC-4u9iL:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG

(Homo sapiens) 		PF04049
(ANAPC8)
PF13181
(TPR_8)
PF13414
(TPR_11) 		4 ILE C 244
ALA C 247
LEU C 248
ILE C 269
 None
 0.84A 5mvmB-4ui9C:
2.5
5mvmC-4ui9C:
2.5		 5mvmB-4ui9C:
9.72
5mvmC-4ui9C:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uym 14-ALPHA STEROL
DEMETHYLASE

(Aspergillus
fumigatus) 		PF00067
(p450) 		4 ILE A 428
ALA A 430
ILE A 363
TYR A 453
 None
 0.83A 5mvmB-4uymA:
undetectable
5mvmC-4uymA:
undetectable		 5mvmB-4uymA:
10.24
5mvmC-4uymA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 ILE A 814
ALA A 818
LEU A 817
ILE A 770
 None
 0.86A 5mvmB-4xriA:
3.3
5mvmC-4xriA:
3.3		 5mvmB-4xriA:
5.57
5mvmC-4xriA:
5.57