SIMILAR PATTERNS OF AMINO ACIDS FOR 5MVM_A_PFLA511

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bym PROTEIN (DIPHTHERIA
TOXIN REPRESSOR)

(Corynebacterium
diphtheriae) 		PF04023
(FeoA) 		4 ILE A 165
ILE A 153
ALA A 155
ILE A 195
 None
 0.75A 5mvmA-1bymA:
0.0
5mvmB-1bymA:
0.0		 5mvmA-1bymA:
22.43
5mvmB-1bymA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ILE B 358
ALA B 416
ILE B 157
ILE B 133
 None
 0.75A 5mvmA-1e9yB:
undetectable
5mvmB-1e9yB:
undetectable		 5mvmA-1e9yB:
10.42
5mvmB-1e9yB:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ILE A 517
ALA A 520
ILE A 526
GLU A 525
 ADX  A 575 ( 4.2A)
None
None
None
 0.68A 5mvmA-1i2dA:
2.2
5mvmB-1i2dA:
2.2		 5mvmA-1i2dA:
9.43
5mvmB-1i2dA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im8 YECO

(Haemophilus
influenzae) 		PF13649
(Methyltransf_25) 		4 ILE A 238
ILE A  41
ALA A  44
ILE A  45
 None
 0.74A 5mvmA-1im8A:
0.0
5mvmB-1im8A:
0.0		 5mvmA-1im8A:
14.75
5mvmB-1im8A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jro XANTHINE
DEHYDROGENASE, CHAIN
A

(Rhodobacter
capsulatus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		4 ILE A 411
ALA A 443
ILE A 382
ALA A 380
 None
 0.67A 5mvmA-1jroA:
0.0
5mvmB-1jroA:
0.0		 5mvmA-1jroA:
10.80
5mvmB-1jroA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		4 ILE A   3
ILE A 134
ALA A 137
ILE A 138
 None
 0.60A 5mvmA-1kczA:
undetectable
5mvmB-1kczA:
undetectable		 5mvmA-1kczA:
16.55
5mvmB-1kczA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1li7 CYSTEINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		4 ILE A  70
ALA A 114
ILE A 121
ILE A 118
 None
 0.70A 5mvmA-1li7A:
2.3
5mvmB-1li7A:
2.3		 5mvmA-1li7A:
11.17
5mvmB-1li7A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		4 ILE A 112
ALA A 115
ILE A 116
GLU A  74
 None
 0.70A 5mvmA-1ny5A:
0.0
5mvmB-1ny5A:
0.0		 5mvmA-1ny5A:
11.69
5mvmB-1ny5A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 ILE A  52
ALA A  97
ALA A  39
ILE A  44
 None
 0.76A 5mvmA-1q5nA:
3.5
5mvmB-1q5nA:
3.4		 5mvmA-1q5nA:
10.31
5mvmB-1q5nA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szq 2-METHYLCITRATE
DEHYDRATASE

(Escherichia
coli) 		PF03972
(MmgE_PrpD) 		4 PRO A 113
ALA A 178
ALA A 159
ILE A 158
 None
 0.72A 5mvmA-1szqA:
undetectable
5mvmB-1szqA:
undetectable		 5mvmA-1szqA:
10.95
5mvmB-1szqA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjy SUGAR TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF13407
(Peripla_BP_4) 		4 ILE A 242
ALA A 228
ILE A 207
ILE A 208
 None
 0.72A 5mvmA-1tjyA:
undetectable
5mvmB-1tjyA:
undetectable		 5mvmA-1tjyA:
13.36
5mvmB-1tjyA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		4 ILE A  69
ILE A  17
ALA A  20
ILE A  21
 None
 0.64A 5mvmA-1un9A:
2.2
5mvmB-1un9A:
undetectable		 5mvmA-1un9A:
9.96
5mvmB-1un9A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		4 ALA A 213
ILE A 178
ALA A 181
ILE A 182
 None
 0.72A 5mvmA-1w27A:
1.6
5mvmB-1w27A:
1.5		 5mvmA-1w27A:
8.51
5mvmB-1w27A:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		4 ILE B 367
ALA B 207
ALA B 214
GLU B 215
 None
 0.68A 5mvmA-1wdwB:
undetectable
5mvmB-1wdwB:
undetectable		 5mvmA-1wdwB:
12.95
5mvmB-1wdwB:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x48 INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Mus musculus) 		PF00035
(dsrm) 		4 ILE A  44
ALA A  16
ALA A  65
TYR A  25
 None
 0.75A 5mvmA-1x48A:
undetectable
5mvmB-1x48A:
undetectable		 5mvmA-1x48A:
18.95
5mvmB-1x48A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhk PUTATIVE PROTEASE LA
HOMOLOG

(Methanocaldococcus
jannaschii) 		PF05362
(Lon_C) 		4 ILE A 479
ALA A 551
ALA A 573
ILE A 574
 None
 0.70A 5mvmA-1xhkA:
undetectable
5mvmB-1xhkA:
undetectable		 5mvmA-1xhkA:
20.59
5mvmB-1xhkA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwv DER F II

(Dermatophagoides
farinae) 		PF02221
(E1_DerP2_DerF2) 		4 ILE A 127
ALA A  98
ALA A  56
ILE A  63
 None
PE3  A1001 ( 3.7A)
PE3  A1001 ( 4.1A)
None
 0.65A 5mvmA-1xwvA:
undetectable
5mvmB-1xwvA:
undetectable		 5mvmA-1xwvA:
23.26
5mvmB-1xwvA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN

(Listeria
monocytogenes) 		PF04608
(PgpA) 		4 ILE A 120
PRO A 125
ILE A 127
ILE A  28
 None
 0.72A 5mvmA-1y9iA:
undetectable
5mvmB-1y9iA:
undetectable		 5mvmA-1y9iA:
19.30
5mvmB-1y9iA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Actinobacillus
succinogenes) 		PF01293
(PEPCK_ATP) 		4 PRO A 483
ILE A 458
ALA A 461
ILE A 462
 None
 0.71A 5mvmA-1yggA:
undetectable
5mvmB-1yggA:
undetectable		 5mvmA-1yggA:
10.69
5mvmB-1yggA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		5 ILE A 367
PRO A 477
ILE A 452
ALA A 455
ILE A 456
 None
 0.86A 5mvmA-1ytmA:
undetectable
5mvmB-1ytmA:
undetectable		 5mvmA-1ytmA:
10.71
5mvmB-1ytmA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1

(Aquifex
aeolicus) 		PF00072
(Response_reg) 		4 ILE A 112
ALA A 115
ILE A 116
GLU A  74
 None
 0.64A 5mvmA-1zy2A:
undetectable
5mvmB-1zy2A:
undetectable		 5mvmA-1zy2A:
23.53
5mvmB-1zy2A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		4 ILE A 430
ALA A 392
ALA A 410
ILE A 411
 None
 0.75A 5mvmA-2d0oA:
undetectable
5mvmB-2d0oA:
undetectable		 5mvmA-2d0oA:
8.13
5mvmB-2d0oA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		4 ILE A 384
ILE A 371
ALA A 374
TYR A 398
 None
 0.71A 5mvmA-2dhtA:
undetectable
5mvmB-2dhtA:
undetectable		 5mvmA-2dhtA:
11.73
5mvmB-2dhtA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Escherichia
coli) 		PF00698
(Acyl_transf_1) 		4 ALA A 223
ALA A 242
ILE A 243
GLU A 237
 None
 0.58A 5mvmA-2g2oA:
undetectable
5mvmB-2g2oA:
1.8		 5mvmA-2g2oA:
15.52
5mvmB-2g2oA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gy5 ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF10430
(Ig_Tie2_1) 		4 ILE A  55
ILE A 113
ILE A 111
GLU A 103
 None
 0.66A 5mvmA-2gy5A:
undetectable
5mvmB-2gy5A:
undetectable		 5mvmA-2gy5A:
12.10
5mvmB-2gy5A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivd PROTOPORPHYRINOGEN
OXIDASE

(Myxococcus
xanthus) 		PF01593
(Amino_oxidase) 		4 PRO A 110
ILE A 196
ALA A 199
ILE A 200
 None
None
None
GOL  A1467 ( 4.8A)
 0.57A 5mvmA-2ivdA:
undetectable
5mvmB-2ivdA:
undetectable		 5mvmA-2ivdA:
11.26
5mvmB-2ivdA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kz4 PUTATIVE HEAD-TAIL
ADAPTOR

(Shigella
flexneri) 		PF05521
(Phage_H_T_join) 		4 ILE A  12
ILE A  61
ALA A  37
ILE A  63
 None
 0.74A 5mvmA-2kz4A:
undetectable
5mvmB-2kz4A:
undetectable		 5mvmA-2kz4A:
19.64
5mvmB-2kz4A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw8 EUGENOL SYNTHASE 1

(Ocimum
basilicum) 		PF05368
(NmrA) 		4 ILE A  98
ILE A 135
ALA A 138
ILE A 139
 None
 0.71A 5mvmA-2qw8A:
undetectable
5mvmB-2qw8A:
undetectable		 5mvmA-2qw8A:
15.03
5mvmB-2qw8A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw8 EUGENOL SYNTHASE 1

(Ocimum
basilicum) 		PF05368
(NmrA) 		4 ILE A 129
ILE A 257
ALA A 260
ILE A 261
 None
None
None
PEG  A 901 (-3.8A)
 0.50A 5mvmA-2qw8A:
undetectable
5mvmB-2qw8A:
undetectable		 5mvmA-2qw8A:
15.03
5mvmB-2qw8A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		5 ILE A 251
ALA A 254
ILE A 260
ALA A  32
ILE A 261
 None
 1.03A 5mvmA-2rb5A:
undetectable
5mvmB-2rb5A:
undetectable		 5mvmA-2rb5A:
14.62
5mvmB-2rb5A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF01128
(IspD) 		4 ALA A   4
ILE A  92
ALA A  95
ILE A  96
 None
 0.40A 5mvmA-2vsiA:
undetectable
5mvmB-2vsiA:
undetectable		 5mvmA-2vsiA:
16.50
5mvmB-2vsiA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb1 DNA-DIRECTED RNA
POLYMERASERPO3
SUBUNIT

(Sulfolobus
shibatae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 ILE D  65
ILE D  98
ALA D 143
ILE D  96
 None
 0.74A 5mvmA-2wb1D:
undetectable
5mvmB-2wb1D:
undetectable		 5mvmA-2wb1D:
17.18
5mvmB-2wb1D:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		4 ALA A 471
ALA A 122
ILE A 123
GLU A 124
 None
 0.65A 5mvmA-2xdrA:
undetectable
5mvmB-2xdrA:
undetectable		 5mvmA-2xdrA:
11.49
5mvmB-2xdrA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 4 ALA A 223
ALA A 272
ILE A 276
GLU A 275
 None
 0.68A 5mvmA-2yr5A:
undetectable
5mvmB-2yr5A:
undetectable		 5mvmA-2yr5A:
8.35
5mvmB-2yr5A:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 LYMPHOCYTE ANTIGEN
96

(Homo sapiens) 		PF02221
(E1_DerP2_DerF2) 		4 ILE C 124
ILE C  52
ALA C  30
ILE C 153
 E55  C   1 ( 4.9A)
E55  C   1 ( 4.5A)
None
E55  C   1 ( 4.8A)
 0.72A 5mvmA-2z65C:
undetectable
5mvmB-2z65C:
undetectable		 5mvmA-2z65C:
22.82
5mvmB-2z65C:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea) 		PF16499
(Melibiase_2) 		4 ILE A  76
ILE A  83
ILE A  28
GLU A  25
 None
 0.63A 5mvmA-3a5vA:
undetectable
5mvmB-3a5vA:
undetectable		 5mvmA-3a5vA:
15.11
5mvmB-3a5vA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 ILE A  47
ALA A  20
ILE A  23
GLU A   9
 None
 0.70A 5mvmA-3d1jA:
undetectable
5mvmB-3d1jA:
undetectable		 5mvmA-3d1jA:
9.73
5mvmB-3d1jA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dme CONSERVED EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF01266
(DAO) 		4 ILE A 319
PRO A 210
ALA A 330
ILE A 348
 None
None
None
FAD  A 500 (-4.6A)
 0.76A 5mvmA-3dmeA:
undetectable
5mvmB-3dmeA:
undetectable		 5mvmA-3dmeA:
12.53
5mvmB-3dmeA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax) 		PF00962
(A_deaminase) 		4 ILE A 144
ALA A 147
ILE A 148
GLU A 106
 None
 0.72A 5mvmA-3ewdA:
undetectable
5mvmB-3ewdA:
undetectable		 5mvmA-3ewdA:
13.36
5mvmB-3ewdA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbl PUTATIVE
UNCHARACTERIZED
PROTEIN

(Acidianus
filamentous
virus 1) 		no annotation 4 ILE A 124
ILE A 103
ALA A 106
ILE A 107
 None
 0.72A 5mvmA-3fblA:
4.3
5mvmB-3fblA:
4.3		 5mvmA-3fblA:
21.51
5mvmB-3fblA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 ILE A 229
ILE A 290
ILE A 292
GLU A 270
 None
 0.73A 5mvmA-3gq9A:
undetectable
5mvmB-3gq9A:
undetectable		 5mvmA-3gq9A:
9.33
5mvmB-3gq9A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h07 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF00926
(DHBP_synthase) 		4 PRO A 139
ILE A 118
ALA A 121
ILE A 122
 None
 0.67A 5mvmA-3h07A:
undetectable
5mvmB-3h07A:
undetectable		 5mvmA-3h07A:
16.75
5mvmB-3h07A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		4 ILE A  81
ALA A  50
ALA A  96
ILE A  97
 None
 0.41A 5mvmA-3hc1A:
undetectable
5mvmB-3hc1A:
undetectable		 5mvmA-3hc1A:
15.41
5mvmB-3hc1A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibh SACCHAROMYCES
CEREVISIAE GTT2

(Saccharomyces
cerevisiae) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ALA A  26
ILE A 193
ALA A 196
ILE A 197
 None
 0.75A 5mvmA-3ibhA:
3.0
5mvmB-3ibhA:
2.2		 5mvmA-3ibhA:
18.53
5mvmB-3ibhA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izk CHAPERONIN

(Methanococcus
maripaludis) 		PF00118
(Cpn60_TCP1) 		4 ILE A 189
ILE A 167
ALA A 171
ILE A 168
 None
 0.74A 5mvmA-3izkA:
2.2
5mvmB-3izkA:
undetectable		 5mvmA-3izkA:
11.30
5mvmB-3izkA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jx8 PUTATIVE LIPOPROTEIN

(Parabacteroides
distasonis) 		PF10988
(DUF2807) 		4 ILE A 265
ALA A 239
ILE A 229
GLU A 246
 None
 0.73A 5mvmA-3jx8A:
undetectable
5mvmB-3jx8A:
undetectable		 5mvmA-3jx8A:
14.34
5mvmB-3jx8A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		4 ILE A 149
ALA A  50
ALA A  57
GLU A  58
 None
 0.71A 5mvmA-3kxwA:
undetectable
5mvmB-3kxwA:
undetectable		 5mvmA-3kxwA:
10.36
5mvmB-3kxwA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm9 PUTATIVE
OXIDOREDUCTASE

(Rhodopseudomonas
palustris) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 ILE A 207
ALA A 170
ILE A 151
ALA A 219
 None
 0.76A 5mvmA-3pm9A:
undetectable
5mvmB-3pm9A:
undetectable		 5mvmA-3pm9A:
10.08
5mvmB-3pm9A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfq PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
MOAB2

(Mycobacterium
marinum) 		PF00994
(MoCF_biosynth) 		4 PRO A 167
ILE A 117
ALA A 120
ILE A 121
 None
 0.43A 5mvmA-3rfqA:
undetectable
5mvmB-3rfqA:
undetectable		 5mvmA-3rfqA:
21.02
5mvmB-3rfqA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		4 ILE B 296
ILE B 348
ALA B 351
ILE B 352
 None
 0.57A 5mvmA-3s4wB:
3.0
5mvmB-3s4wB:
3.0		 5mvmA-3s4wB:
4.39
5mvmB-3s4wB:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE

(Vibrio cholerae) 		PF00857
(Isochorismatase) 		4 ILE A   6
PRO A   4
ALA A  48
ILE A  51
 BOG  A 501 ( 4.4A)
None
None
None
 0.73A 5mvmA-3tb4A:
undetectable
5mvmB-3tb4A:
undetectable		 5mvmA-3tb4A:
14.35
5mvmB-3tb4A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqn TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Coxiella
burnetii) 		PF00392
(GntR) 		4 PRO A  34
ILE A  18
ALA A  21
ILE A  22
 None
 0.71A 5mvmA-3tqnA:
undetectable
5mvmB-3tqnA:
undetectable		 5mvmA-3tqnA:
18.58
5mvmB-3tqnA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 ILE A  93
ILE A 312
ALA A 316
ILE A 313
 None
 0.76A 5mvmA-3uc3A:
2.9
5mvmB-3uc3A:
2.9		 5mvmA-3uc3A:
13.03
5mvmB-3uc3A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2i PEPTIDYL-TRNA
HYDROLASE

(Burkholderia
thailandensis) 		PF01195
(Pept_tRNA_hydro) 		4 ALA A  22
ILE A 170
ALA A 173
ILE A 174
 None
 0.59A 5mvmA-3v2iA:
undetectable
5mvmB-3v2iA:
undetectable		 5mvmA-3v2iA:
16.36
5mvmB-3v2iA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		4 PRO A 213
ALA A 182
ALA A 148
ILE A 149
 None
 0.76A 5mvmA-3vv3A:
undetectable
5mvmB-3vv3A:
undetectable		 5mvmA-3vv3A:
11.84
5mvmB-3vv3A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		4 ILE A 797
ILE A 543
ALA A 546
ILE A 547
 None
 0.60A 5mvmA-4aioA:
undetectable
5mvmB-4aioA:
undetectable		 5mvmA-4aioA:
7.10
5mvmB-4aioA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atq 4-AMINOBUTYRATE
TRANSAMINASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		4 ILE A 230
ALA A 256
ALA A 211
ILE A 215
 None
 0.70A 5mvmA-4atqA:
undetectable
5mvmB-4atqA:
undetectable		 5mvmA-4atqA:
9.15
5mvmB-4atqA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 377
ALA A 380
ILE A 381
GLU A 384
 None
 0.58A 5mvmA-4b99A:
undetectable
5mvmB-4b99A:
undetectable		 5mvmA-4b99A:
11.29
5mvmB-4b99A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus cereus) 		PF00268
(Ribonuc_red_sm) 		4 ILE A 188
ILE A 192
GLU A 195
TYR A 100
 None
None
FE2  A1323 (-2.8A)
None
 0.74A 5mvmA-4bmrA:
2.7
5mvmB-4bmrA:
2.3		 5mvmA-4bmrA:
17.31
5mvmB-4bmrA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE

(Staphylococcus
aureus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ILE A 305
ALA A 308
ALA A 325
ILE A 322
 None
 0.75A 5mvmA-4c13A:
undetectable
5mvmB-4c13A:
undetectable		 5mvmA-4c13A:
11.35
5mvmB-4c13A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger) 		PF01979
(Amidohydro_1) 		4 PRO A  87
ALA A  69
ALA A  78
GLU A 427
 None
 0.70A 5mvmA-4c60A:
undetectable
5mvmB-4c60A:
undetectable		 5mvmA-4c60A:
10.34
5mvmB-4c60A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		4 ILE A 259
PRO A 257
ALA A 297
ILE A 294
 None
 0.63A 5mvmA-4cemA:
3.0
5mvmB-4cemA:
2.3		 5mvmA-4cemA:
12.43
5mvmB-4cemA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5r A49

(Vaccinia virus) 		PF06489
(Orthopox_A49R) 		4 ILE A 137
ILE A 109
ALA A 112
ILE A 113
 None
 0.54A 5mvmA-4d5rA:
undetectable
5mvmB-4d5rA:
undetectable		 5mvmA-4d5rA:
23.13
5mvmB-4d5rA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 ILE A  11
ALA A  22
ALA A 444
ILE A 445
 None
 0.68A 5mvmA-4dshA:
undetectable
5mvmB-4dshA:
undetectable		 5mvmA-4dshA:
9.38
5mvmB-4dshA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ebj AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE

(Pseudomonas
aeruginosa) 		PF01909
(NTP_transf_2) 		4 ILE A 139
ALA A 207
ALA A 214
GLU A 215
 None
 0.67A 5mvmA-4ebjA:
2.2
5mvmB-4ebjA:
undetectable		 5mvmA-4ebjA:
14.45
5mvmB-4ebjA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ege DIPEPTIDASE PEPE

(Mycobacterium
ulcerans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ILE A 186
ALA A 189
ILE A 190
GLU A 193
 None
 0.57A 5mvmA-4egeA:
undetectable
5mvmB-4egeA:
undetectable		 5mvmA-4egeA:
12.23
5mvmB-4egeA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehj PHOSPHOGLYCERATE
KINASE

(Francisella
tularensis) 		PF00162
(PGK) 		4 ILE A 106
ILE A  37
ALA A  40
ILE A  41
 None
 0.47A 5mvmA-4ehjA:
undetectable
5mvmB-4ehjA:
undetectable		 5mvmA-4ehjA:
13.66
5mvmB-4ehjA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)

(Mycobacteroides
abscessus) 		PF00202
(Aminotran_3) 		4 ILE A 225
ALA A 251
ALA A 206
ILE A 210
 None
 0.67A 5mvmA-4ffcA:
undetectable
5mvmB-4ffcA:
undetectable		 5mvmA-4ffcA:
10.71
5mvmB-4ffcA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g81 PUTATIVE HEXONATE
DEHYDROGENASE

(Salmonella
enterica) 		no annotation 4 ALA D  32
ILE D 227
ALA D 230
ILE D 231
 None
 0.58A 5mvmA-4g81D:
undetectable
5mvmB-4g81D:
undetectable		 5mvmA-4g81D:
15.58
5mvmB-4g81D:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 PRO C 620
ILE C 651
ILE C 652
GLU C 655
 None
 0.70A 5mvmA-4hb4C:
2.8
5mvmB-4hb4C:
2.7		 5mvmA-4hb4C:
6.53
5mvmB-4hb4C:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht4 NICKING ENZYME

(Staphylococcus
aureus) 		PF03389
(MobA_MobL) 		4 ALA A 108
ILE A  89
ILE A  87
GLU A  86
 None
 0.70A 5mvmA-4ht4A:
1.5
5mvmB-4ht4A:
1.7		 5mvmA-4ht4A:
19.21
5mvmB-4ht4A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlz UNCHARACTERIZED
PROTEIN

(Sus scrofa) 		PF03281
(Mab-21) 		5 ILE A 293
ALA A 156
ILE A 153
ALA A 197
GLU A 200
 None
 1.41A 5mvmA-4jlzA:
2.0
5mvmB-4jlzA:
2.2		 5mvmA-4jlzA:
11.39
5mvmB-4jlzA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mks ENOLASE 2

(Lactobacillus
gasseri) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 PRO A 129
ALA A 139
ILE A 409
ALA A 412
 None
 0.71A 5mvmA-4mksA:
undetectable
5mvmB-4mksA:
undetectable		 5mvmA-4mksA:
11.65
5mvmB-4mksA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio cholerae) 		PF03116
(NQR2_RnfD_RnfE) 		4 ILE B 169
ALA B 205
ILE B 183
ALA B 179
 None
 0.72A 5mvmA-4p6vB:
undetectable
5mvmB-4p6vB:
undetectable		 5mvmA-4p6vB:
14.94
5mvmB-4p6vB:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE

(Roseobacter
denitrificans) 		PF03480
(DctP) 		4 ALA A 122
ILE A 130
ILE A 126
GLU A 125
 None
 0.76A 5mvmA-4pc9A:
undetectable
5mvmB-4pc9A:
undetectable		 5mvmA-4pc9A:
12.78
5mvmB-4pc9A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjw PORIN O

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		4 ILE A 220
ALA A 297
ALA A 135
GLU A 138
 None
 0.65A 5mvmA-4rjwA:
undetectable
5mvmB-4rjwA:
undetectable		 5mvmA-4rjwA:
11.19
5mvmB-4rjwA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpa PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 ALA A  58
ILE A  17
ALA A  20
ILE A  21
 None
 0.64A 5mvmA-4rpaA:
undetectable
5mvmB-4rpaA:
undetectable		 5mvmA-4rpaA:
17.67
5mvmB-4rpaA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN

(Burkholderia
pseudomallei) 		PF06429
(Flg_bbr_C) 		4 ALA A 305
ILE A 107
ALA A 110
ILE A 111
 None
EDO  A1642 (-4.3A)
EDO  A1629 ( 4.3A)
None
 0.44A 5mvmA-4ut1A:
4.1
5mvmB-4ut1A:
4.1		 5mvmA-4ut1A:
7.16
5mvmB-4ut1A:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yot 3-5 EXONUCLEASE
PHOEXO I

(Pyrococcus
horikoshii) 		PF13680
(DUF4152) 		4 ALA A 120
ILE A  62
ALA A  65
ILE A  66
 None
 0.47A 5mvmA-4yotA:
undetectable
5mvmB-4yotA:
undetectable		 5mvmA-4yotA:
16.29
5mvmB-4yotA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxg UNCHARACTERIZED
BETA-SANDWICH
PROTEIN

(Clostridioides
difficile) 		no annotation 4 ILE A 114
ILE A  60
ALA A  96
ILE A  62
 None
 0.73A 5mvmA-5bxgA:
undetectable
5mvmB-5bxgA:
undetectable		 5mvmA-5bxgA:
20.37
5mvmB-5bxgA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwf DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 ILE A 121
ILE A 128
ALA A 167
ILE A 166
 None
 0.77A 5mvmA-5cwfA:
undetectable
5mvmB-5cwfA:
2.1		 5mvmA-5cwfA:
16.23
5mvmB-5cwfA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5er3 SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13407
(Peripla_BP_4) 		5 ILE A 281
PRO A 271
ILE A 213
ALA A 268
ILE A 267
 None
 1.01A 5mvmA-5er3A:
undetectable
5mvmB-5er3A:
undetectable		 5mvmA-5er3A:
11.08
5mvmB-5er3A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ern FUSICOCCADIENE
SYNTHASE

(Diaporthe
amygdali) 		PF00348
(polyprenyl_synt) 		4 ILE A 182
ILE A 120
ALA A 123
ILE A 124
 None
 0.60A 5mvmA-5ernA:
4.1
5mvmB-5ernA:
4.2		 5mvmA-5ernA:
13.50
5mvmB-5ernA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j04 ENOLASE

(Synechococcus
elongatus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 PRO A 133
ALA A 143
ILE A 409
ALA A 412
 None
 0.67A 5mvmA-5j04A:
undetectable
5mvmB-5j04A:
undetectable		 5mvmA-5j04A:
11.78
5mvmB-5j04A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		4 ILE B 189
ALA B 225
ILE B 224
TYR B 253
 None
 0.72A 5mvmA-5k7mB:
undetectable
5mvmB-5k7mB:
undetectable		 5mvmA-5k7mB:
13.62
5mvmB-5k7mB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6e N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		4 ILE B 189
ALA B 225
ILE B 224
TYR B 253
 None
 0.75A 5mvmA-5l6eB:
undetectable
5mvmB-5l6eB:
undetectable		 5mvmA-5l6eB:
17.83
5mvmB-5l6eB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		4 ILE A 227
ILE A 366
ALA A 369
ILE A 370
 None
 0.74A 5mvmA-5lv9A:
undetectable
5mvmB-5lv9A:
undetectable		 5mvmA-5lv9A:
9.29
5mvmB-5lv9A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT

(Homo sapiens) 		no annotation 4 PRO A 915
ALA A 946
ALA A 960
ILE A 959
 None
 0.76A 5mvmA-5nprA:
undetectable
5mvmB-5nprA:
undetectable		 5mvmA-5nprA:
26.67
5mvmB-5nprA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tey N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		4 ILE B 189
ALA B 225
ILE B 224
TYR B 253
 None
 0.77A 5mvmA-5teyB:
undetectable
5mvmB-5teyB:
undetectable		 5mvmA-5teyB:
11.03
5mvmB-5teyB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s DNA REPLICATION
LICENSING FACTOR
MCM4

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 ALA 4 793
ILE 4 829
ALA 4 832
ILE 4 833
 None
 0.70A 5mvmA-5u8s4:
undetectable
5mvmB-5u8s4:
undetectable		 5mvmA-5u8s4:
7.09
5mvmB-5u8s4:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE

(Haemophilus
influenzae) 		PF02219
(MTHFR) 		4 ILE A  71
ALA A  74
ILE A  75
GLU A  78
 None
 0.56A 5mvmA-5umeA:
undetectable
5mvmB-5umeA:
undetectable		 5mvmA-5umeA:
14.39
5mvmB-5umeA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF13401
(AAA_22)
PF14630
(ORC5_C) 		4 ILE E 349
ILE E 389
ALA E 392
ILE E 393
 None
 0.74A 5mvmA-5v8fE:
undetectable
5mvmB-5v8fE:
undetectable		 5mvmA-5v8fE:
10.45
5mvmB-5v8fE:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn3 ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF00517
(GP41) 		4 ILE A 622
ALA G 497
ILE A 635
GLU A 634
 None
 0.76A 5mvmA-5vn3A:
undetectable
5mvmB-5vn3A:
undetectable		 5mvmA-5vn3A:
18.71
5mvmB-5vn3A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1a -

(-) 		no annotation 4 PRO A 106
ILE A  37
ILE A  41
GLU A  42
 None
 0.76A 5mvmA-5y1aA:
undetectable
5mvmB-5y1aA:
undetectable		 5mvmA-5y1aA:
undetectable
5mvmB-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 4 ILE 2 544
ILE 2 512
ALA 2 514
ILE 2 515
 None
 0.68A 5mvmA-5zvs2:
undetectable
5mvmB-5zvs2:
undetectable		 5mvmA-5zvs2:
20.99
5mvmB-5zvs2:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 4 ALA A 200
ILE A 165
ALA A 168
ILE A 169
 None
 0.67A 5mvmA-6at7A:
1.3
5mvmB-6at7A:
1.3		 5mvmA-6at7A:
26.19
5mvmB-6at7A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)

(Escherichia
coli) 		no annotation 4 PRO A 483
ILE A 458
ALA A 461
ILE A 462
 None
 0.76A 5mvmA-6d5iA:
undetectable
5mvmB-6d5iA:
undetectable		 5mvmA-6d5iA:
18.29
5mvmB-6d5iA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfp VCA0883

(Vibrio cholerae) 		no annotation 4 ALA A  27
ILE A 354
ILE A 356
GLU A 357
 None
 0.69A 5mvmA-6dfpA:
3.9
5mvmB-6dfpA:
2.5		 5mvmA-6dfpA:
19.10
5mvmB-6dfpA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsf GTPASE-ACTIVATING
PROTEIN BEM3

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A 517
ALA A 536
ILE A 537
GLU A 545
 None
 0.75A 5mvmA-6fsfA:
undetectable
5mvmB-6fsfA:
undetectable		 5mvmA-6fsfA:
21.84
5mvmB-6fsfA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 1,
MITOCHONDRIAL

(Mus musculus) 		no annotation 4 ILE F 298
ILE F 343
ALA F 346
ILE F 347
 None
 0.61A 5mvmA-6g2jF:
undetectable
5mvmB-6g2jF:
undetectable		 5mvmA-6g2jF:
17.50
5mvmB-6g2jF:
17.50