SIMILAR PATTERNS OF AMINO ACIDS FOR 5MVM_A_PFLA510

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezi CMP-N-ACETYLNEURAMIN
IC ACID SYNTHETASE

(Neisseria
meningitidis) 		PF02348
(CTP_transf_3) 		5 ILE A  49
ALA A   7
ILE A   6
ALA A  89
LEU A  90
 None
 1.11A 5mvmA-1eziA:
0.0
5mvmE-1eziA:
0.0		 5mvmA-1eziA:
14.60
5mvmE-1eziA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 ALA A 262
ILE A 263
ILE A 279
ALA A 265
LEU A 268
 None
 1.11A 5mvmA-1f82A:
0.0
5mvmE-1f82A:
0.0		 5mvmA-1f82A:
10.90
5mvmE-1f82A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		5 ILE A  62
ALA A  60
ILE A 103
PRO A 105
ALA A  91
 None
 0.90A 5mvmA-1ghsA:
0.0
5mvmE-1ghsA:
0.0		 5mvmA-1ghsA:
15.83
5mvmE-1ghsA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Escherichia
coli) 		PF02668
(TauD) 		5 ALA A 246
ILE A 247
ILE A  18
ALA A  38
LEU A  35
 None
 1.12A 5mvmA-1gy9A:
0.0
5mvmE-1gy9A:
0.0		 5mvmA-1gy9A:
15.30
5mvmE-1gy9A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkg HEXOKINASE A

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A 363
ILE A 362
TYR A 397
ILE A 324
LEU A 289
 None
 1.06A 5mvmA-1hkgA:
0.0
5mvmE-1hkgA:
0.0		 5mvmA-1hkgA:
10.48
5mvmE-1hkgA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ALA A 149
ILE A 148
ILE A 134
ALA A 126
LEU A 123
 None
 1.04A 5mvmA-1hkwA:
undetectable
5mvmE-1hkwA:
0.0		 5mvmA-1hkwA:
10.87
5mvmE-1hkwA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htr GASTRICSIN
PROGASTRICSIN (PRO
SEGMENT)

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		5 ILE B 303
ALA B 214
ILE B 215
PRO B 226
ALA P  35
 None
 1.03A 5mvmA-1htrB:
0.0
5mvmE-1htrB:
undetectable		 5mvmA-1htrB:
17.39
5mvmE-1htrB:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		5 ILE A 241
ILE A 244
ILE A 222
ALA A 292
LEU A 295
 None
 0.96A 5mvmA-1j1uA:
0.0
5mvmE-1j1uA:
0.0		 5mvmA-1j1uA:
16.53
5mvmE-1j1uA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermotoga
maritima) 		PF00218
(IGPS) 		5 ILE A  58
ALA A  85
ILE A  83
PRO A  69
ALA A  74
 None
 1.13A 5mvmA-1j5tA:
0.0
5mvmE-1j5tA:
0.0		 5mvmA-1j5tA:
16.20
5mvmE-1j5tA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		5 ILE A 466
ALA A 468
ILE A 469
ILE A 515
LEU A 501
 None
 1.06A 5mvmA-1jqoA:
3.9
5mvmE-1jqoA:
3.9		 5mvmA-1jqoA:
6.71
5mvmE-1jqoA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		5 ALA B 308
ILE B 299
PRO B 289
ALA B 281
LEU B 272
 None
 1.09A 5mvmA-1jtdB:
undetectable
5mvmE-1jtdB:
undetectable		 5mvmA-1jtdB:
13.06
5mvmE-1jtdB:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 ALA A 583
ILE A 584
TYR A 955
ILE A 951
LEU A 359
 None
 1.10A 5mvmA-1p2zA:
undetectable
5mvmE-1p2zA:
undetectable		 5mvmA-1p2zA:
7.22
5mvmE-1p2zA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE

(Salmonella
enterica) 		PF02525
(Flavodoxin_2) 		5 ILE A  92
ALA A 135
ILE A  90
ILE A 164
LEU A  84
 None
 0.86A 5mvmA-1t5bA:
undetectable
5mvmE-1t5bA:
undetectable		 5mvmA-1t5bA:
19.34
5mvmE-1t5bA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF14519
(Macro_2) 		5 ILE A 271
ILE A 275
ILE A 231
ALA A 212
LEU A 215
 None
 1.00A 5mvmA-1txzA:
undetectable
5mvmE-1txzA:
undetectable		 5mvmA-1txzA:
14.59
5mvmE-1txzA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		5 ILE C 623
ALA C 625
ILE C 626
ILE C 577
LEU C 595
 None
 1.11A 5mvmA-1wa5C:
4.1
5mvmE-1wa5C:
3.7		 5mvmA-1wa5C:
6.25
5mvmE-1wa5C:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtz RIBOSE-5-PHOSPHATE
ISOMERASE

(Saccharomyces
cerevisiae) 		PF06026
(Rib_5-P_isom_A) 		5 ILE A 140
ALA A 105
ILE A 104
ILE A  57
LEU A  34
 None
 1.04A 5mvmA-1xtzA:
undetectable
5mvmE-1xtzA:
undetectable		 5mvmA-1xtzA:
14.92
5mvmE-1xtzA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 ILE A 674
ALA A 626
ILE A 611
ALA A 659
LEU A 666
 None
 1.00A 5mvmA-1yq2A:
undetectable
5mvmE-1yq2A:
1.2		 5mvmA-1yq2A:
6.56
5mvmE-1yq2A:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		5 ILE A 452
ALA A 455
ILE A 456
ILE A 367
PRO A 477
 None
 0.90A 5mvmA-1ytmA:
undetectable
5mvmE-1ytmA:
undetectable		 5mvmA-1ytmA:
10.71
5mvmE-1ytmA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9d URIDYLATE KINASE

(Streptococcus
pyogenes) 		PF00696
(AA_kinase) 		5 ILE A  10
ILE A  12
ILE A 129
ALA A  50
LEU A  51
 None
 1.08A 5mvmA-1z9dA:
undetectable
5mvmE-1z9dA:
undetectable		 5mvmA-1z9dA:
15.00
5mvmE-1z9dA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqz 177AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13023
(HD_3) 		5 ILE A 129
ALA A 149
ILE A 150
ILE A 122
LEU A 166
 None
 0.94A 5mvmA-2cqzA:
undetectable
5mvmE-2cqzA:
undetectable		 5mvmA-2cqzA:
17.42
5mvmE-2cqzA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		5 ILE A 445
ILE A 520
ILE A 461
ALA A 447
LEU A 450
 None
 1.07A 5mvmA-2d0oA:
undetectable
5mvmE-2d0oA:
undetectable		 5mvmA-2d0oA:
8.13
5mvmE-2d0oA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5i AZO REDUCTASE

(Escherichia
coli) 		PF02525
(Flavodoxin_2) 		5 ILE A  91
ALA A 134
ILE A  89
ILE A 163
LEU A  83
 None
 0.83A 5mvmA-2d5iA:
undetectable
5mvmE-2d5iA:
undetectable		 5mvmA-2d5iA:
17.33
5mvmE-2d5iA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db0 253AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF02985
(HEAT) 		5 ILE A  55
ALA A  27
ILE A  59
ILE A  38
LEU A  66
 None
 1.13A 5mvmA-2db0A:
1.9
5mvmE-2db0A:
1.9		 5mvmA-2db0A:
16.14
5mvmE-2db0A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		5 ALA X 512
ILE X 509
ILE X 581
ALA X 525
LEU X 577
 None
 1.12A 5mvmA-2epkX:
4.2
5mvmE-2epkX:
4.2		 5mvmA-2epkX:
10.04
5mvmE-2epkX:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9r SPHINGOMYELINASE D 1

(Loxosceles
laeta) 		no annotation 5 ILE A 249
ILE A   7
ILE A 258
PRO A 254
LEU A 261
 None
 0.98A 5mvmA-2f9rA:
undetectable
5mvmE-2f9rA:
undetectable		 5mvmA-2f9rA:
14.74
5mvmE-2f9rA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Sulfurisphaera
tokodaii) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		5 ALA A 318
ILE A 317
ILE A 377
PRO A  16
ALA A 357
 None
 1.08A 5mvmA-2ggqA:
undetectable
5mvmE-2ggqA:
undetectable		 5mvmA-2ggqA:
13.47
5mvmE-2ggqA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsz TWITCHING MOTILITY
PROTEIN PILT

(Aquifex
aeolicus) 		PF00437
(T2SSE) 		5 ALA A 246
ILE A 247
ILE A 306
PRO A 298
LEU A 311
 None
 1.07A 5mvmA-2gszA:
undetectable
5mvmE-2gszA:
undetectable		 5mvmA-2gszA:
14.63
5mvmE-2gszA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i75 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ILE A 714
TYR A 723
ILE A 883
ALA A 868
LEU A 871
 None
 1.00A 5mvmA-2i75A:
undetectable
5mvmE-2i75A:
undetectable		 5mvmA-2i75A:
11.99
5mvmE-2i75A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 ILE A  64
ILE A  45
ILE A  67
ALA A  23
LEU A  29
 None
FAD  A 401 (-4.3A)
None
None
None
 1.12A 5mvmA-2mbrA:
undetectable
5mvmE-2mbrA:
undetectable		 5mvmA-2mbrA:
13.85
5mvmE-2mbrA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		5 ALA A 873
ILE A 872
ILE A 861
ALA A 806
LEU A 830
 None
 1.02A 5mvmA-2oajA:
undetectable
5mvmE-2oajA:
undetectable		 5mvmA-2oajA:
6.88
5mvmE-2oajA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 ALA A 548
ILE A 549
TYR A 920
ILE A 916
LEU A 329
 None
 1.06A 5mvmA-2obeA:
undetectable
5mvmE-2obeA:
undetectable		 5mvmA-2obeA:
7.78
5mvmE-2obeA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		5 ILE A  39
ALA A  42
ILE A  43
ILE A 115
LEU A  88
 None
 0.71A 5mvmA-2paaA:
undetectable
5mvmE-2paaA:
undetectable		 5mvmA-2paaA:
12.36
5mvmE-2paaA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE

(Azospirillum
brasilense) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A 141
ILE A 145
ILE A 163
ALA A   4
LEU A   7
 None
 1.12A 5mvmA-2q5oA:
undetectable
5mvmE-2q5oA:
undetectable		 5mvmA-2q5oA:
9.22
5mvmE-2q5oA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7x UPF0052 PROTEIN
SP_1565

(Streptococcus
pneumoniae) 		PF01933
(UPF0052) 		5 ILE A 218
ALA A 219
ILE A 252
ILE A 198
LEU A 243
 None
 1.13A 5mvmA-2q7xA:
undetectable
5mvmE-2q7xA:
undetectable		 5mvmA-2q7xA:
12.08
5mvmE-2q7xA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		5 ILE A 260
ALA A  32
ILE A 261
ILE A 251
ALA A 254
 None
 1.13A 5mvmA-2rb5A:
undetectable
5mvmE-2rb5A:
undetectable		 5mvmA-2rb5A:
14.62
5mvmE-2rb5A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf1 CAPSID PROTEIN

(Rabbit
picobirnavirus) 		no annotation 5 ILE A 236
ALA A 178
ILE A 175
ILE A 248
LEU A 241
 None
 1.04A 5mvmA-2vf1A:
undetectable
5mvmE-2vf1A:
undetectable		 5mvmA-2vf1A:
11.07
5mvmE-2vf1A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vo1 CTP SYNTHASE 1

(Homo sapiens) 		PF06418
(CTP_synth_N) 		5 ILE A  18
ALA A  20
ILE A  19
ILE A  26
LEU A 257
 None
 1.13A 5mvmA-2vo1A:
undetectable
5mvmE-2vo1A:
undetectable		 5mvmA-2vo1A:
14.61
5mvmE-2vo1A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgb TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR

(Mycolicibacterium
smegmatis) 		PF00440
(TetR_N) 		5 ILE A 171
ALA A 174
ILE A 175
ALA A 157
LEU A 154
 None
 1.01A 5mvmA-2wgbA:
2.6
5mvmE-2wgbA:
2.6		 5mvmA-2wgbA:
17.71
5mvmE-2wgbA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME

(Candidatus
Cloacimonas
acidaminovorans) 		PF05853
(BKACE) 		5 ALA A 154
ILE A 157
ILE A 169
ALA A 200
LEU A 167
 None
 1.02A 5mvmA-2y7dA:
undetectable
5mvmE-2y7dA:
undetectable		 5mvmA-2y7dA:
13.17
5mvmE-2y7dA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526

(Sulfurisphaera
tokodaii) 		PF01300
(Sua5_yciO_yrdC)
PF03481
(SUA5) 		5 ALA A  31
ILE A 171
ILE A 140
ALA A 129
LEU A 132
 None
 1.11A 5mvmA-3ajeA:
undetectable
5mvmE-3ajeA:
undetectable		 5mvmA-3ajeA:
11.61
5mvmE-3ajeA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526

(Sulfurisphaera
tokodaii) 		PF01300
(Sua5_yciO_yrdC)
PF03481
(SUA5) 		5 ILE A 171
ALA A  20
ILE A  17
ILE A 133
ALA A 129
 None
 1.12A 5mvmA-3ajeA:
undetectable
5mvmE-3ajeA:
undetectable		 5mvmA-3ajeA:
11.61
5mvmE-3ajeA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beu TRYPSIN

(Streptomyces
griseus) 		PF00089
(Trypsin) 		5 ALA A 237
ILE A 238
PRO A  92
ALA A 104
LEU A 105
 None
 0.88A 5mvmA-3beuA:
undetectable
5mvmE-3beuA:
undetectable		 5mvmA-3beuA:
19.44
5mvmE-3beuA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boe CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 ILE A 412
ALA A 414
ILE A 229
ALA A 232
LEU A 233
 None
 1.02A 5mvmA-3boeA:
undetectable
5mvmE-3boeA:
undetectable		 5mvmA-3boeA:
18.03
5mvmE-3boeA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cea MYO-INOSITOL
2-DEHYDROGENASE

(Lactobacillus
plantarum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A  13
ALA A  11
ILE A  12
ALA A  40
LEU A  15
 NAD  A 400 (-4.9A)
None
None
NAD  A 400 (-3.6A)
None
 1.04A 5mvmA-3ceaA:
undetectable
5mvmE-3ceaA:
undetectable		 5mvmA-3ceaA:
12.38
5mvmE-3ceaA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dli METHYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF13489
(Methyltransf_23) 		5 ILE A 470
ALA A 468
ILE A 469
TYR A 276
ILE A 348
 None
 1.01A 5mvmA-3dliA:
undetectable
5mvmE-3dliA:
undetectable		 5mvmA-3dliA:
14.83
5mvmE-3dliA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		5 ILE A 360
ALA A 358
ILE A 359
ILE A  48
LEU A  74
 None
 1.14A 5mvmA-3ed4A:
undetectable
5mvmE-3ed4A:
undetectable		 5mvmA-3ed4A:
9.92
5mvmE-3ed4A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		5 ALA A  96
ILE A  97
ILE A  81
ALA A  50
LEU A  53
 None
 0.74A 5mvmA-3hc1A:
undetectable
5mvmE-3hc1A:
undetectable		 5mvmA-3hc1A:
15.41
5mvmE-3hc1A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihl CTP SYNTHASE 2

(Homo sapiens) 		PF06418
(CTP_synth_N) 		5 ILE A  18
ALA A  20
ILE A  19
ILE A  26
LEU A 257
 ADP  A 300 (-4.3A)
None
None
None
None
 1.03A 5mvmA-3ihlA:
undetectable
5mvmE-3ihlA:
undetectable		 5mvmA-3ihlA:
13.28
5mvmE-3ihlA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il3 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Haemophilus
influenzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A 165
ALA A 134
ILE A  73
ILE A 137
ALA A  59
 None
 1.12A 5mvmA-3il3A:
undetectable
5mvmE-3il3A:
undetectable		 5mvmA-3il3A:
15.86
5mvmE-3il3A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN A
INTRACELLULAR GROWTH
LOCUS PROTEIN B

(Francisella
tularensis) 		PF05591
(T6SS_VipA)
PF05943
(VipB) 		5 ALA B 165
ILE B 197
TYR A  30
ILE B 309
LEU B 292
 None
 1.14A 5mvmA-3j9oB:
undetectable
5mvmE-3j9oB:
undetectable		 5mvmA-3j9oB:
13.62
5mvmE-3j9oB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 ILE A 285
ALA A 314
ILE A 336
ALA A 338
LEU A 339
 None
 1.03A 5mvmA-3juxA:
4.7
5mvmE-3juxA:
4.8		 5mvmA-3juxA:
7.32
5mvmE-3juxA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF01823
(MACPF) 		5 ALA A 263
ILE A 264
ILE A 291
ALA A 241
LEU A 179
 None
 1.11A 5mvmA-3kk7A:
undetectable
5mvmE-3kk7A:
undetectable		 5mvmA-3kk7A:
9.23
5mvmE-3kk7A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 314
ALA A 310
ILE A 271
ALA A 274
LEU A 275
 None
 1.04A 5mvmA-3kumA:
undetectable
5mvmE-3kumA:
undetectable		 5mvmA-3kumA:
16.79
5mvmE-3kumA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lma STAGE V SPORULATION
PROTEIN AD (SPOVAD)

(Bacillus
licheniformis) 		PF07451
(SpoVAD) 		5 ALA A 118
ILE A 117
ILE A 124
ALA A 132
LEU A 173
 None
 1.13A 5mvmA-3lmaA:
undetectable
5mvmE-3lmaA:
undetectable		 5mvmA-3lmaA:
12.87
5mvmE-3lmaA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nre ALDOSE 1-EPIMERASE

(Escherichia
coli) 		PF01263
(Aldose_epim) 		5 ILE A 222
ALA A 220
ILE A 221
ILE A 159
ALA A 210
 None
 1.05A 5mvmA-3nreA:
undetectable
5mvmE-3nreA:
undetectable		 5mvmA-3nreA:
13.15
5mvmE-3nreA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oji ABSCISIC ACID
RECEPTOR PYL3

(Arabidopsis
thaliana) 		PF10604
(Polyketide_cyc2) 		5 ALA A  64
ILE A  65
ILE A 203
ALA A 201
LEU A 200
 None
 0.90A 5mvmA-3ojiA:
undetectable
5mvmE-3ojiA:
undetectable		 5mvmA-3ojiA:
20.23
5mvmE-3ojiA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bacillus
halodurans) 		PF00171
(Aldedh) 		5 ILE A  43
ILE A  14
ILE A 222
ALA A  45
LEU A  46
 None
 1.08A 5mvmA-3prlA:
undetectable
5mvmE-3prlA:
undetectable		 5mvmA-3prlA:
10.45
5mvmE-3prlA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3v PHOSPHOGLYCERATE
KINASE

(Campylobacter
jejuni) 		PF00162
(PGK) 		5 ILE A  39
ALA A  42
ILE A  43
ILE A 112
LEU A  85
 None
 0.71A 5mvmA-3q3vA:
undetectable
5mvmE-3q3vA:
undetectable		 5mvmA-3q3vA:
10.95
5mvmE-3q3vA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxb PUTATIVE XYLOSE
ISOMERASE

(Rhodospirillum
rubrum) 		PF01261
(AP_endonuc_2) 		5 ALA A 100
ILE A 101
TYR A  37
ALA A 111
LEU A 153
 None
 0.94A 5mvmA-3qxbA:
undetectable
5mvmE-3qxbA:
undetectable		 5mvmA-3qxbA:
14.05
5mvmE-3qxbA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhd LACTALDEHYDE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00171
(Aldedh) 		5 ILE A 217
ALA A 233
ILE A 229
ALA A 239
LEU A 240
 None
 1.12A 5mvmA-3rhdA:
undetectable
5mvmE-3rhdA:
undetectable		 5mvmA-3rhdA:
12.06
5mvmE-3rhdA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t32 AMINOTRANSFERASE,
CLASS I/II

(Bacillus
anthracis) 		PF00155
(Aminotran_1_2) 		5 ILE A 223
ALA A 194
ILE A  91
ALA A  94
LEU A  95
 None
None
LLP  A 230 ( 4.2A)
None
None
 1.01A 5mvmA-3t32A:
undetectable
5mvmE-3t32A:
undetectable		 5mvmA-3t32A:
12.37
5mvmE-3t32A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdg PROBABLE GLUCARATE
DEHYDRATASE

(Mycolicibacterium
smegmatis) 		PF13378
(MR_MLE_C) 		5 ILE A 183
ALA A 149
ILE A 191
ILE A 175
LEU A 210
 None
 1.12A 5mvmA-3vdgA:
undetectable
5mvmE-3vdgA:
undetectable		 5mvmA-3vdgA:
11.40
5mvmE-3vdgA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		6 ALA A 530
ILE A 531
TYR A 899
ILE A 895
ALA A 316
LEU A 315
 None
 1.46A 5mvmA-3zifA:
undetectable
5mvmE-3zifA:
undetectable		 5mvmA-3zifA:
6.84
5mvmE-3zifA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyf PANTETHEINASE

(Homo sapiens) 		PF00795
(CN_hydrolase) 		5 ILE A  75
ALA A  72
ILE A  74
ILE A 279
LEU A 263
 None
 1.08A 5mvmA-4cyfA:
undetectable
5mvmE-4cyfA:
undetectable		 5mvmA-4cyfA:
9.33
5mvmE-4cyfA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 ILE A 497
ALA A 378
ILE A 442
ALA A 475
LEU A 479
 None
 1.12A 5mvmA-4cyjA:
undetectable
5mvmE-4cyjA:
undetectable		 5mvmA-4cyjA:
11.58
5mvmE-4cyjA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Thermobispora
bispora) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 178
ALA A 144
ILE A 186
ILE A 170
LEU A 205
 None
 1.13A 5mvmA-4dhgA:
undetectable
5mvmE-4dhgA:
undetectable		 5mvmA-4dhgA:
13.26
5mvmE-4dhgA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4r PHOSPHATE
ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF01515
(PTA_PTB) 		5 ILE A 237
ALA A 235
ILE A 236
ALA A 199
LEU A 261
 CL  A 507 (-4.8A)
None
CL  A 507 (-4.6A)
None
None
 1.07A 5mvmA-4e4rA:
undetectable
5mvmE-4e4rA:
undetectable		 5mvmA-4e4rA:
12.05
5mvmE-4e4rA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ese FMN-DEPENDENT
NADH-AZOREDUCTASE

(Yersinia pestis) 		PF02525
(Flavodoxin_2) 		5 ILE A  92
ALA A 135
ILE A  90
ILE A 164
LEU A  84
 None
 0.85A 5mvmA-4eseA:
undetectable
5mvmE-4eseA:
undetectable		 5mvmA-4eseA:
17.88
5mvmE-4eseA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 ILE C 702
ALA C 700
ILE C 699
ILE C 766
LEU C 731
 None
 1.07A 5mvmA-4hb4C:
2.7
5mvmE-4hb4C:
2.7		 5mvmA-4hb4C:
6.53
5mvmE-4hb4C:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Ruegeria sp.
TM1040) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 106
ILE A 107
ILE A  65
ALA A  67
LEU A  68
 None
 1.12A 5mvmA-4ip4A:
undetectable
5mvmE-4ip4A:
undetectable		 5mvmA-4ip4A:
13.22
5mvmE-4ip4A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it1 PUTATIVE GLUCARATE
DEHYDRATASE

(Pseudomonas
fluorescens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 182
ALA A 146
ILE A 190
ILE A 174
LEU A 209
 None
 1.09A 5mvmA-4it1A:
undetectable
5mvmE-4it1A:
undetectable		 5mvmA-4it1A:
12.59
5mvmE-4it1A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kva SEPTIN

(Schistosoma
mansoni) 		PF00735
(Septin) 		5 ILE A 164
ALA A 168
TYR A 104
ILE A 154
LEU A 161
 None
 0.83A 5mvmA-4kvaA:
undetectable
5mvmE-4kvaA:
undetectable		 5mvmA-4kvaA:
11.60
5mvmE-4kvaA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leu PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT3G46870

(Arabidopsis
thaliana) 		PF13041
(PPR_2) 		5 ILE A  73
ALA A  77
ILE A  81
ILE A 114
LEU A 117
 None
 1.03A 5mvmA-4leuA:
undetectable
5mvmE-4leuA:
undetectable		 5mvmA-4leuA:
16.80
5mvmE-4leuA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A 399
TYR A 367
ILE A 175
PRO A 173
ALA A 165
 None
 1.09A 5mvmA-4mmoA:
undetectable
5mvmE-4mmoA:
undetectable		 5mvmA-4mmoA:
11.86
5mvmE-4mmoA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5p THIJ/PFPI FAMILY
PROTEIN

(Francisella
tularensis) 		PF01965
(DJ-1_PfpI) 		5 ILE A  97
ALA A  95
ILE A  96
ILE A 203
ALA A 130
 None
 1.03A 5mvmA-4p5pA:
undetectable
5mvmE-4p5pA:
undetectable		 5mvmA-4p5pA:
16.04
5mvmE-4p5pA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		5 ILE A 596
ALA A 594
ILE A 595
ALA A 603
LEU A 606
 None
 1.14A 5mvmA-4q2cA:
undetectable
5mvmE-4q2cA:
undetectable		 5mvmA-4q2cA:
5.81
5mvmE-4q2cA:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F

(Thermococcus
kodakarensis) 		PF03874
(RNA_pol_Rpb4) 		5 ILE F 112
ALA F 108
ILE F 111
ILE F  95
LEU F  81
 None
 0.96A 5mvmA-4qiwF:
undetectable
5mvmE-4qiwF:
undetectable		 5mvmA-4qiwF:
25.62
5mvmE-4qiwF:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgk UNCHARACTERIZED
PROTEIN

(Yersinia pestis) 		PF07350
(DUF1479) 		5 ILE A  10
ALA A  13
ILE A  14
ALA A 300
LEU A 297
 None
 1.04A 5mvmA-4rgkA:
undetectable
5mvmE-4rgkA:
undetectable		 5mvmA-4rgkA:
12.68
5mvmE-4rgkA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnu ASPARTOACYLASE

(Homo sapiens) 		PF04952
(AstE_AspA) 		5 ILE A 111
ALA A  15
ILE A 199
ALA A 202
LEU A 203
 None
 1.04A 5mvmA-4tnuA:
undetectable
5mvmE-4tnuA:
undetectable		 5mvmA-4tnuA:
14.24
5mvmE-4tnuA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 203
ALA A 205
ILE A 204
GLU A 221
ILE A 289
 None
 1.13A 5mvmA-4uy9A:
undetectable
5mvmE-4uy9A:
undetectable		 5mvmA-4uy9A:
12.38
5mvmE-4uy9A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bym SUPPRESSOR PROTEIN
MPT5

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 ILE A 336
ALA A 363
ILE A 360
ILE A 398
LEU A 386
 None
 1.09A 5mvmA-5bymA:
undetectable
5mvmE-5bymA:
undetectable		 5mvmA-5bymA:
11.20
5mvmE-5bymA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgk ACTIVE HELICASE

(Staphylococcus
aureus) 		PF06048
(DUF927) 		5 ILE A 445
ALA A 444
ILE A 448
ILE A 516
LEU A 544
 None
 1.01A 5mvmA-5dgkA:
undetectable
5mvmE-5dgkA:
2.5		 5mvmA-5dgkA:
10.28
5mvmE-5dgkA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00144
(Beta-lactamase) 		5 ILE B  29
ALA B  30
ILE B  31
ALA B 351
LEU B 355
 None
 1.05A 5mvmA-5eviB:
undetectable
5mvmE-5eviB:
undetectable		 5mvmA-5eviB:
13.78
5mvmE-5eviB:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		5 ILE A 313
ALA A 312
ILE A 455
ALA A 385
LEU A 382
 None
 1.14A 5mvmA-5gooA:
undetectable
5mvmE-5gooA:
undetectable		 5mvmA-5gooA:
13.37
5mvmE-5gooA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
putida) 		PF00903
(Glyoxalase)
PF01261
(AP_endonuc_2)
PF14696
(Glyoxalase_5) 		5 ALA A 523
ILE A 601
GLU A 599
PRO A 496
LEU A 584
 MG  A 702 ( 4.4A)
None
MG  A 702 (-2.5A)
None
None
 1.08A 5mvmA-5hmqA:
undetectable
5mvmE-5hmqA:
undetectable		 5mvmA-5hmqA:
8.84
5mvmE-5hmqA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihv BETA-LACTAMASE

(Burkholderia
ambifaria) 		PF13354
(Beta-lactamase2) 		5 ALA A 197
ILE A 198
ILE A  24
ALA A 237
LEU A 236
 None
 0.94A 5mvmA-5ihvA:
undetectable
5mvmE-5ihvA:
undetectable		 5mvmA-5ihvA:
18.27
5mvmE-5ihvA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imu TAT (TWIN-ARGININE
TRANSLOCATION)
PATHWAY SIGNAL
SEQUENCE CONTAINING
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A 327
ILE A 324
ILE A 382
ALA A 343
LEU A 346
 None
 0.95A 5mvmA-5imuA:
2.4
5mvmE-5imuA:
2.4		 5mvmA-5imuA:
17.83
5mvmE-5imuA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jx5 GLUCANASE

(Orpinomyces sp.
Y102) 		PF01341
(Glyco_hydro_6) 		5 ILE A 308
ALA A 291
ILE A 250
ILE A 245
LEU A 272
 None
None
EDO  A 507 (-3.7A)
None
None
 1.08A 5mvmA-5jx5A:
undetectable
5mvmE-5jx5A:
undetectable		 5mvmA-5jx5A:
13.88
5mvmE-5jx5A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		5 ILE A 801
ALA A 798
ILE A 797
TYR A 758
ILE A 681
 None
 0.94A 5mvmA-5ksdA:
2.7
5mvmE-5ksdA:
2.8		 5mvmA-5ksdA:
7.61
5mvmE-5ksdA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn HEXON PROTEIN,HEXON
CAPSID

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 ALA A 567
ILE A 568
TYR A 939
ILE A 935
LEU A 347
 None
 0.98A 5mvmA-5ldnA:
undetectable
5mvmE-5ldnA:
undetectable		 5mvmA-5ldnA:
7.35
5mvmE-5ldnA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkf POLYCYSTIN-2

(Homo sapiens) 		PF08016
(PKD_channel) 		5 ALA A 474
ILE A 478
GLU A 477
TYR A 465
ILE A 526
 None
 0.85A 5mvmA-5mkfA:
4.4
5mvmE-5mkfA:
4.7		 5mvmA-5mkfA:
6.26
5mvmE-5mkfA:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 5 ALA A 604
ILE A 605
ILE A 569
ALA A 599
LEU A 593
 None
 0.94A 5mvmA-5n94A:
undetectable
5mvmE-5n94A:
undetectable		 5mvmA-5n94A:
20.93
5mvmE-5n94A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0i 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8

(Homo sapiens) 		PF00004
(AAA) 		5 ILE d 182
ALA d 179
ILE d 178
ALA d 194
LEU d 198
 None
 0.98A 5mvmA-5t0id:
3.2
5mvmE-5t0id:
undetectable		 5mvmA-5t0id:
12.50
5mvmE-5t0id:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgz 26S PROTEASOME
REGULATORY SUBUNIT
10B
26S PROTEASOME
REGULATORY SUBUNIT
6A

(Homo sapiens) 		no annotation 5 GLU E 114
ILE F  94
PRO F 147
ALA F 122
LEU F  96
 None
 1.13A 5mvmA-5vgzE:
undetectable
5mvmE-5vgzE:
undetectable		 5mvmA-5vgzE:
18.69
5mvmE-5vgzE:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c13 -

(-) 		no annotation 5 ILE A1326
ALA A1325
TYR A1316
ILE A1155
ALA A1287
 None
 1.12A 5mvmA-6c13A:
undetectable
5mvmE-6c13A:
undetectable		 5mvmA-6c13A:
undetectable
5mvmE-6c13A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP40

(Homo sapiens) 		no annotation 5 ILE G 237
ILE G 229
ILE G 253
ALA G 251
LEU G 250
 None
 1.14A 5mvmA-6d6qG:
undetectable
5mvmE-6d6qG:
undetectable		 5mvmA-6d6qG:
24.44
5mvmE-6d6qG:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 5 ILE A  44
ALA A  47
ILE A 229
ILE A  62
ALA A  71
 None
 1.13A 5mvmA-6et7A:
2.9
5mvmE-6et7A:
5.8		 5mvmA-6et7A:
21.35
5mvmE-6et7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8y THREONYLCARBAMOYL-AM
P SYNTHASE

(Pyrococcus
abyssi) 		no annotation 5 ALA A  30
ILE A 170
ILE A 139
ALA A 128
LEU A 131
 None
 1.05A 5mvmA-6f8yA:
undetectable
5mvmE-6f8yA:
undetectable		 5mvmA-6f8yA:
18.60
5mvmE-6f8yA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8y THREONYLCARBAMOYL-AM
P SYNTHASE

(Pyrococcus
abyssi) 		no annotation 5 ILE A 170
ALA A  19
ILE A  16
ILE A 132
ALA A 128
 None
 1.13A 5mvmA-6f8yA:
undetectable
5mvmE-6f8yA:
undetectable		 5mvmA-6f8yA:
18.60
5mvmE-6f8yA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 5 ILE A 217
ALA A 219
ILE A 220
ALA A 312
LEU A 311
 None
 1.12A 5mvmA-6fn1A:
3.6
5mvmE-6fn1A:
1.6		 5mvmA-6fn1A:
17.50
5mvmE-6fn1A:
17.50