SIMILAR PATTERNS OF AMINO ACIDS FOR 5MUR_E_PFLE406

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1alq CP254 BETA-LACTAMASE

(Staphylococcus
aureus) 		PF13354
(Beta-lactamase2) 		5 PRO A 162
ILE A  75
ILE A 139
ILE A 142
ILE A 138
 None
 1.05A 5murE-1alqA:
0.3		 5murE-1alqA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b63 MUTL

(Escherichia
coli) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		5 ILE A  56
ILE A  54
ILE A 171
ILE A 175
ILE A 174
 None
 1.02A 5murE-1b63A:
0.0		 5murE-1b63A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyg CYCLODEXTRIN
GLUCANOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 ILE A  55
ILE A  58
ILE A  71
ILE A  73
ILE A  17
 None
 1.01A 5murE-1cygA:
0.0		 5murE-1cygA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dof ADENYLOSUCCINATE
LYASE

(Pyrobaculum
aerophilum) 		PF00206
(Lyase_1) 		5 ILE A  24
ILE A  25
ILE A  74
ILE A 100
ILE A  99
 None
 0.98A 5murE-1dofA:
2.6		 5murE-1dofA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pisum sativum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 TYR A 313
ILE A 144
ILE A 145
ILE A 126
ILE A  35
 None
 1.08A 5murE-1dxlA:
undetectable		 5murE-1dxlA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eke RIBONUCLEASE HII

(Methanocaldococcus
jannaschii) 		PF01351
(RNase_HII) 		5 ILE A   3
ILE A   4
ILE A 111
ILE A 143
ILE A 142
 None
 1.10A 5murE-1ekeA:
0.0		 5murE-1ekeA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eke RIBONUCLEASE HII

(Methanocaldococcus
jannaschii) 		PF01351
(RNase_HII) 		5 ILE A   4
ILE A 107
ILE A 142
ILE A 111
ILE A 143
 None
 1.09A 5murE-1ekeA:
0.0		 5murE-1ekeA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE

(Homo sapiens) 		PF00494
(SQS_PSY) 		5 ILE A 263
THR A 359
ILE A 362
ILE A 363
ILE A 366
 None
 1.05A 5murE-1ezfA:
0.0		 5murE-1ezfA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE

(Homo sapiens) 		PF00494
(SQS_PSY) 		5 TYR A 341
ILE A 297
ILE A 363
ILE A 366
ILE A 362
 None
 1.01A 5murE-1ezfA:
0.0		 5murE-1ezfA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2h HYPOTHETICAL PROTEIN
TM1643

(Thermotoga
maritima) 		PF01958
(DUF108)
PF03447
(NAD_binding_3) 		5 ILE A   6
ILE A   5
ILE A  76
ILE A  77
ILE A  78
 None
None
None
None
NAD  A1242 (-4.3A)
 1.01A 5murE-1h2hA:
undetectable		 5murE-1h2hA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		5 TYR A  56
ILE A 246
ILE A 156
ILE A 219
ILE A 217
 AGS  A 503 (-3.3A)
None
None
AGS  A 503 ( 4.3A)
None
 1.01A 5murE-1k6mA:
0.0		 5murE-1k6mA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mmf GLYCEROL DEHYDRASE
BETA SUBUNIT

(Klebsiella
pneumoniae) 		PF02288
(Dehydratase_MU) 		5 ILE B  54
THR B 105
ILE B  99
ILE B  97
ILE B  32
 None
 1.10A 5murE-1mmfB:
undetectable		 5murE-1mmfB:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pio BETA-LACTAMASE

(Staphylococcus
aureus) 		PF13354
(Beta-lactamase2) 		5 PRO A 162
ILE A  75
ILE A 139
ILE A 142
ILE A 138
 None
 1.09A 5murE-1pioA:
undetectable		 5murE-1pioA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00117
(GATase) 		5 TYR B  27
PRO B  28
ILE B   6
ILE B  44
ILE B  41
 None
 0.99A 5murE-1qdlB:
undetectable		 5murE-1qdlB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5a GLUTATHIONE
TRANSFERASE

(Anopheles
cracens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 TYR A  73
TYR A  78
ILE A  24
ILE A 156
ILE A 159
 None
 1.09A 5murE-1r5aA:
3.0		 5murE-1r5aA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tve HOMOSERINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 ILE A 153
ILE A 230
ILE A 169
ILE A 321
ILE A 323
 None
 1.02A 5murE-1tveA:
undetectable		 5murE-1tveA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 PRO A 276
TYR A 246
ILE A 271
ILE A 267
ILE A 217
 None
 1.08A 5murE-1vzoA:
undetectable		 5murE-1vzoA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ylx HYPOTHETICAL PROTEIN
APC35702

(Geobacillus
stearothermophilus) 		no annotation 5 ILE A  98
MET A  94
ILE A  54
ILE A  47
ILE A  56
 None
 1.12A 5murE-1ylxA:
undetectable		 5murE-1ylxA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 TYR A 363
ILE A 350
ILE A 297
ILE A 296
ILE A 298
 None
 1.09A 5murE-1zgjA:
undetectable		 5murE-1zgjA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg4 REGULATORY PROTEIN
ASNC

(Escherichia
coli) 		PF01037
(AsnC_trans_reg)
PF13404
(HTH_AsnC-type) 		5 ILE A 130
THR A 136
ILE A  74
ILE A  72
ILE A 109
 None
 1.01A 5murE-2cg4A:
undetectable		 5murE-2cg4A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 5 ILE A 119
ILE A 118
ILE A 247
ILE A 249
ILE A 248
 None
 1.04A 5murE-2cl2A:
undetectable		 5murE-2cl2A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 5 PRO A 100
ILE A 119
ILE A 249
ILE A 248
ILE A 247
 None
 0.87A 5murE-2cl2A:
undetectable		 5murE-2cl2A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e87 HYPOTHETICAL PROTEIN
PH1320

(Pyrococcus
horikoshii) 		PF06858
(NOG1) 		5 ILE A 250
THR A 221
ILE A 172
ILE A 219
ILE A 218
 None
 1.10A 5murE-2e87A:
4.4		 5murE-2e87A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9z CHEMOTAXIS PROTEIN
CHEC

(Thermotoga
maritima) 		PF04509
(CheC) 		5 ILE A  59
ILE A 142
ILE A 148
ILE A 145
ILE A  78
 None
 1.01A 5murE-2f9zA:
undetectable		 5murE-2f9zA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im9 HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		PF07313
(DUF1460) 		5 ILE A 337
ILE A 270
ILE A 272
ILE A 273
ILE A 289
 None
 1.10A 5murE-2im9A:
undetectable		 5murE-2im9A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 PRO A  68
THR A  66
ILE A  65
ILE A  64
ILE A  63
 None
 1.02A 5murE-2j6iA:
undetectable		 5murE-2j6iA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph5 HOMOSPERMIDINE
SYNTHASE

(Legionella
pneumophila) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 TYR A 433
ILE A  32
ILE A 404
ILE A 405
ILE A 408
 None
 0.89A 5murE-2ph5A:
undetectable		 5murE-2ph5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA

(-) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A  64
ILE A  61
THR A 103
ILE A 106
ILE A  37
 None
 1.01A 5murE-2qgyA:
undetectable		 5murE-2qgyA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qh9 UPF0215 PROTEIN
AF_1433

(Archaeoglobus
fulgidus) 		PF01949
(DUF99) 		5 TYR A 134
ILE A 127
ILE A 135
ILE A  70
ILE A  80
 None
 1.08A 5murE-2qh9A:
undetectable		 5murE-2qh9A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF01128
(IspD) 		5 ILE A  92
THR A  79
ILE A  78
ILE A  77
ILE A  76
 None
 0.99A 5murE-2vsiA:
undetectable		 5murE-2vsiA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 TYR A 112
ILE A 109
ILE A  38
ILE A  96
ILE A  54
 None
 1.09A 5murE-2vwkA:
3.1		 5murE-2vwkA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxr BOTULINUM NEUROTOXIN
TYPE G

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 TYR A 996
ILE A 973
ILE A 979
ILE A1012
ILE A1014
 None
 1.08A 5murE-2vxrA:
undetectable		 5murE-2vxrA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxr BOTULINUM NEUROTOXIN
TYPE G

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 TYR A 996
ILE A 979
ILE A1024
ILE A1012
ILE A1014
 None
 0.91A 5murE-2vxrA:
undetectable		 5murE-2vxrA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2d BOTULINUM NEUROTOXIN
A HEAVY CHAIN

(Clostridium
botulinum) 		PF07952
(Toxin_trans) 		5 ILE B 784
ILE B 637
ILE B 633
ILE B 632
ILE B 630
 None
 1.07A 5murE-2w2dB:
2.9		 5murE-2w2dB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 ILE A 338
ILE A 335
ILE A 377
ILE A 373
ILE A 374
 None
 0.94A 5murE-2xpzA:
4.6		 5murE-2xpzA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT

(Thermus
thermophilus) 		PF00344
(SecY) 		6 ILE Y 283
ILE Y 280
THR Y  82
ILE Y  85
ILE Y  86
ILE Y  89
 None
 1.38A 5murE-2zqpY:
undetectable		 5murE-2zqpY:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abi PUTATIVE
UNCHARACTERIZED
PROTEIN PH1688

(Pyrococcus
horikoshii) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 ILE A 336
THR A 302
ILE A 305
ILE A 306
ILE A 309
 None
 0.93A 5murE-3abiA:
undetectable		 5murE-3abiA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6e INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF04851
(ResIII) 		5 ILE A 441
ILE A 442
ILE A 326
ILE A 327
ILE A 325
 None
 1.04A 5murE-3b6eA:
undetectable		 5murE-3b6eA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bit FACT COMPLEX SUBUNIT
SPT16

(Saccharomyces
cerevisiae) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 TYR A  19
ILE A  15
ILE A  65
ILE A  73
ILE A  74
 None
 1.09A 5murE-3bitA:
undetectable		 5murE-3bitA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 ILE A  58
ILE A  61
ILE A  74
ILE A  76
ILE A  20
 None
 1.05A 5murE-3bmwA:
undetectable		 5murE-3bmwA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3by9 SENSOR PROTEIN

(Vibrio cholerae) 		PF02743
(dCache_1) 		6 TYR A 132
TYR A 102
ILE A 104
ILE A 172
ILE A 137
ILE A 168
 SIN  A 287 (-4.4A)
None
None
None
None
None
 1.28A 5murE-3by9A:
undetectable		 5murE-3by9A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE

(Clostridium
acetobutylicum) 		PF13685
(Fe-ADH_2) 		5 TYR A  45
ILE A  94
ILE A  24
ILE A  56
ILE A  28
 EDO  A 403 ( 4.2A)
None
None
None
None
 1.11A 5murE-3ce9A:
undetectable		 5murE-3ce9A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		5 PRO A 111
TYR A 163
ILE A 158
ILE A  62
ILE A  65
 None
 0.98A 5murE-3cskA:
undetectable		 5murE-3cskA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d79 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0734

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF09183
(DUF1947) 		5 PRO A 134
TYR A  75
ILE A  72
ILE A 137
ILE A  61
 None
 1.10A 5murE-3d79A:
undetectable		 5murE-3d79A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt0 PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Bacillus cereus) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 TYR A  76
ILE A  79
ILE A  80
ILE A  87
ILE A  86
 None
 0.96A 5murE-3gt0A:
undetectable		 5murE-3gt0A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwk METHYLCITRATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		5 PRO A 170
MET A 103
THR A 153
ILE A 157
ILE A 154
 None
 1.07A 5murE-3hwkA:
undetectable		 5murE-3hwkA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb8 COAT PROTEIN

(Maize chlorotic
mottle virus) 		PF00729
(Viral_coat) 		5 ILE A 122
ILE A 150
MET A 124
ILE A 209
ILE A 108
 None
 0.92A 5murE-3jb8A:
undetectable		 5murE-3jb8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khd PYRUVATE KINASE

(Plasmodium
falciparum) 		PF00224
(PK)
PF02887
(PK_C) 		5 ILE A 214
ILE A 213
THR A 112
ILE A 234
ILE A 261
 None
 0.99A 5murE-3khdA:
undetectable		 5murE-3khdA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8j PROGRAMMED CELL
DEATH PROTEIN 10

(Homo sapiens) 		PF06840
(DUF1241) 		5 TYR A  27
THR A  59
ILE A  62
ILE A  63
ILE A  66
 None
 1.11A 5murE-3l8jA:
5.9		 5murE-3l8jA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnl UPF0135 PROTEIN
SA1388

(Staphylococcus
aureus) 		PF01784
(NIF3) 		5 TYR A  84
ILE A  87
ILE A  88
ILE A  65
ILE A  96
 None
 1.07A 5murE-3lnlA:
undetectable		 5murE-3lnlA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgw LYSOZYME G

(Salmo salar) 		PF01464
(SLT) 		5 ILE A 121
ILE A 124
ILE A  65
ILE A  66
ILE A  69
 None
 0.64A 5murE-3mgwA:
undetectable		 5murE-3mgwA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpp BOTULINUM NEUROTOXIN
TYPE G

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 TYR G 996
ILE G 973
ILE G 979
ILE G1012
ILE G1014
 None
 1.05A 5murE-3mppG:
undetectable		 5murE-3mppG:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpp BOTULINUM NEUROTOXIN
TYPE G

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 TYR G 996
ILE G 979
ILE G1024
ILE G1012
ILE G1014
 None
 0.91A 5murE-3mppG:
undetectable		 5murE-3mppG:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		5 ILE A1341
ILE A1343
ILE A1307
ILE A1305
ILE A1306
 None
 1.11A 5murE-3poyA:
undetectable		 5murE-3poyA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 PRO A 166
ILE A 180
ILE A 148
ILE A 145
ILE A 149
 None
 0.97A 5murE-3ry7A:
undetectable		 5murE-3ry7A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5r TRANSCRIPTIONAL
REGULATOR TETR
FAMILY

(Syntrophus
aciditrophicus) 		PF00440
(TetR_N) 		5 PRO A 128
ILE A  72
ILE A 158
ILE A 162
ILE A 161
 None
None
None
PEG  A 302 (-4.6A)
None
 1.05A 5murE-3s5rA:
2.6		 5murE-3s5rA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s90 VINCULIN

(Homo sapiens) 		PF01044
(Vinculin) 		5 ILE A 175
ILE A 134
MET A 171
ILE A 241
ILE A 141
 None
 1.12A 5murE-3s90A:
8.0		 5murE-3s90A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0p DNA POLYMERASE III,
BETA SUBUNIT

([Eubacterium]
rectale) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 ILE A  61
MET A   1
ILE A  66
ILE A  35
ILE A  67
 None
 1.09A 5murE-3t0pA:
undetectable		 5murE-3t0pA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvi ASPARTOKINASE

(Clostridium
acetobutylicum) 		PF00696
(AA_kinase)
PF01842
(ACT) 		5 ILE A 320
ILE A 354
ILE A 300
ILE A 302
ILE A 367
 None
 0.90A 5murE-3tviA:
undetectable		 5murE-3tviA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 ILE A 170
THR A 252
ILE A 255
ILE A 256
ILE A 259
 None
 0.73A 5murE-3u1kA:
2.8		 5murE-3u1kA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vp7 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 30

(Saccharomyces
cerevisiae) 		PF04111
(APG6) 		5 ILE A 364
THR A 443
ILE A 446
ILE A 447
ILE A 450
 None
 0.61A 5murE-3vp7A:
undetectable		 5murE-3vp7A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuu ERYTHROCYTE MEMBRANE
PROTEIN, PUTATIVE

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		5 TYR A 288
ILE A 215
ILE A 271
ILE A 270
ILE A 267
 None
 0.91A 5murE-3vuuA:
3.2		 5murE-3vuuA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		5 ILE A 834
ILE A 687
ILE A 683
ILE A 682
ILE A 680
 None
 1.07A 5murE-3zusA:
2.9		 5murE-3zusA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl0 CELL CYCLE ARREST
PROTEIN BUB3

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ILE A 124
ILE A 116
ILE A 107
ILE A 104
ILE A  81
 None
 1.08A 5murE-4bl0A:
undetectable		 5murE-4bl0A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 ILE H 535
ILE H 539
ILE H 594
ILE H 590
ILE H 591
 None
 1.10A 5murE-4c8qH:
undetectable		 5murE-4c8qH:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejy 3-METHYLADENINE DNA
GLYCOSYLASE

(Caldanaerobacter
subterraneus) 		PF00730
(HhH-GPD)
PF07934
(OGG_N) 		5 TYR A 182
ILE A 122
ILE A 183
ILE A 132
ILE A 136
 None
 1.07A 5murE-4ejyA:
undetectable		 5murE-4ejyA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gd3 HYDROGENASE-1 SMALL
CHAIN

(Escherichia
coli) 		no annotation 5 PRO S 142
MET S 163
ILE S 144
ILE S 110
ILE S 159
 None
 1.03A 5murE-4gd3S:
undetectable		 5murE-4gd3S:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inj LMO1638 PROTEIN

(Listeria
monocytogenes) 		PF02016
(Peptidase_S66) 		5 ILE A 127
THR A 308
ILE A 200
ILE A 199
ILE A 201
 None
 1.10A 5murE-4injA:
undetectable		 5murE-4injA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohj TOXIC SHOCK SYNDROME
TOXIN-1

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C) 		5 PRO A 157
ILE A 173
ILE A 223
ILE A 226
ILE A 221
 None
 0.97A 5murE-4ohjA:
undetectable		 5murE-4ohjA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI

(Staphylococcus
aureus) 		PF02976
(MutH) 		5 ILE A 225
ILE A 240
ILE A 232
ILE A 142
ILE A 146
 None
 1.08A 5murE-4pxgA:
undetectable		 5murE-4pxgA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN

(Bacteroides
fragilis) 		PF01368
(DHH) 		5 ILE A 170
MET A 174
ILE A 194
ILE A 193
ILE A 190
 None
 0.98A 5murE-4py9A:
undetectable		 5murE-4py9A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhr ALANINE RACEMASE

(Acinetobacter
baumannii) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ILE A 271
ILE A 305
ILE A 268
ILE A 241
ILE A 240
 None
 1.12A 5murE-4qhrA:
undetectable		 5murE-4qhrA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 TYR A 626
ILE A 637
ILE A 636
ILE A 491
ILE A 492
 None
 1.02A 5murE-4qiwA:
4.4		 5murE-4qiwA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F

(Thermococcus
kodakarensis) 		PF03874
(RNA_pol_Rpb4) 		5 ILE F  95
ILE F  84
ILE F 115
ILE F 111
ILE F 112
 None
 1.04A 5murE-4qiwF:
undetectable		 5murE-4qiwF:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE

(Nonlabens
dokdonensis) 		PF01593
(Amino_oxidase) 		5 ILE A 311
ILE A 409
ILE A 394
ILE A 397
ILE A 393
 None
 0.95A 5murE-4repA:
undetectable		 5murE-4repA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		8 PRO A 120
ILE A 208
ILE A 209
MET A 212
THR A 262
ILE A 265
ILE A 266
ILE A 269
 None
 0.70A 5murE-4yeuA:
20.1		 5murE-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		8 TYR A 204
ILE A 208
ILE A 209
MET A 212
THR A 262
ILE A 265
ILE A 266
ILE A 269
 None
 0.71A 5murE-4yeuA:
20.1		 5murE-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yo1 DEGQ

(Legionella
pneumophila) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 ILE A  69
ILE A  77
ILE A 234
ILE A 235
ILE A 104
 None
 0.90A 5murE-4yo1A:
undetectable		 5murE-4yo1A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D

(Homo sapiens) 		PF00856
(SET) 		5 TYR A5388
ILE A5494
ILE A5496
ILE A5424
ILE A5473
 None
 1.10A 5murE-4z4pA:
undetectable		 5murE-4z4pA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 ILE A 675
ILE A 680
MET A 679
ILE A 432
ILE A 464
 None
 0.90A 5murE-5a3fA:
3.2		 5murE-5a3fA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN

(Candidatus
Nitrososphaera
gargensis) 		PF00561
(Abhydrolase_1) 		5 TYR A 196
MET A  74
ILE A 103
ILE A 100
ILE A 104
 None
None
None
ACT  A 484 (-3.8A)
None
 1.06A 5murE-5a62A:
undetectable		 5murE-5a62A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anr PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE B 243
MET B 168
ILE B 263
ILE B 230
ILE B 226
 None
 1.08A 5murE-5anrB:
undetectable		 5murE-5anrB:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c90 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Staphylococcus
aureus) 		PF00574
(CLP_protease) 		5 ILE A  30
ILE A  29
ILE A  91
ILE A  64
ILE A  93
 None
 1.03A 5murE-5c90A:
undetectable		 5murE-5c90A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 ILE A 181
ILE A 180
ILE A 161
ILE A 162
ILE A 165
 None
 0.85A 5murE-5dbxA:
undetectable		 5murE-5dbxA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME COMPONENT
C8, PUTATIVE

(Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ILE G 151
THR G  79
ILE G  78
ILE G  77
ILE G  76
 None
 1.02A 5murE-5fmgG:
undetectable		 5murE-5fmgG:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1

(Schizosaccharomyces
pombe) 		PF09427
(DUF2014) 		5 PRO A 733
ILE A 738
ILE A 729
ILE A 728
ILE A 725
 None
 0.92A 5murE-5gpdA:
undetectable		 5murE-5gpdA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		5 TYR A 182
ILE A 134
ILE A 181
ILE A 124
ILE A 118
 None
 1.04A 5murE-5gu6A:
undetectable		 5murE-5gu6A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig9 ATP GRASP LIGASE

(Microcystis
aeruginosa) 		no annotation 6 TYR A 256
ILE A 262
THR A 227
ILE A 225
ILE A 218
ILE A 220
 None
 1.33A 5murE-5ig9A:
undetectable		 5murE-5ig9A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l94 CYTOCHROME P450

(Bacillus
megaterium) 		PF00067
(p450) 		5 ILE A 370
THR A 254
ILE A 255
ILE A 251
ILE A 134
 None
 1.11A 5murE-5l94A:
undetectable		 5murE-5l94A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 ILE A 535
ILE A 539
ILE A 594
ILE A 590
ILE A 591
 None
 0.94A 5murE-5lmgA:
2.7		 5murE-5lmgA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 TYR A 516
ILE A  98
ILE A 111
ILE A 112
ILE A  43
 None
 1.09A 5murE-5n0cA:
undetectable		 5murE-5n0cA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TYR A 222
THR A 135
ILE A 132
ILE A 131
ILE A 128
 None
 0.98A 5murE-5t1aA:
3.7		 5murE-5t1aA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		5 TYR A 131
ILE A 278
ILE A  88
ILE A 260
ILE A 261
 None
 1.08A 5murE-5t1pA:
undetectable		 5murE-5t1pA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN-CONTAINING
FORMYLMETHANOFURAN
DEHYDROGENASE 2
SUBUNIT C

(Methanothermobacter
wolfeii) 		PF01493
(GXGXG) 		5 ILE C 128
ILE C 126
ILE C 171
ILE C 173
ILE C 172
 None
 0.96A 5murE-5t5iC:
undetectable		 5murE-5t5iC:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9x GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		no annotation 5 ILE A 192
ILE A 191
ILE A 298
ILE A 300
ILE A 299
 None
 1.10A 5murE-5t9xA:
undetectable		 5murE-5t9xA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj1 DNA TOPOISOMERASE 1

(Mycobacterium
tuberculosis) 		no annotation 5 TYR A 537
ILE A 540
ILE A 541
ILE A 202
ILE A 203
 None
 1.09A 5murE-5uj1A:
undetectable		 5murE-5uj1A:
28.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 10 TYR C 119
PRO C 120
TYR C 197
ILE C 201
ILE C 202
MET C 205
THR C 255
ILE C 258
ILE C 259
ILE C 262
 None
 0.42A 5murE-5v6nC:
36.0		 5murE-5v6nC:
97.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 5 ILE A 166
ILE A  92
ILE A 178
ILE A 174
ILE A 175
 None
 0.90A 5murE-5wlhA:
undetectable		 5murE-5wlhA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC

(Zea mays) 		no annotation 5 ILE 4 246
THR 2 152
ILE 2 155
ILE 2 156
ILE 2 159
 CLA  4 613 (-3.8A)
None
CLA  4 614 ( 4.3A)
CLA  4 614 (-4.0A)
CLA  4 601 (-4.8A)
 0.70A 5murE-5zji4:
undetectable		 5murE-5zji4:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 5 ILE A 641
ILE A 740
ILE A 744
ILE A 745
ILE A 564
 None
 0.92A 5murE-6d6vA:
4.2		 5murE-6d6vA:
18.75