SIMILAR PATTERNS OF AMINO ACIDS FOR 5MUR_B_PFLB407_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9a HYPOTHETICAL PROTEIN
MJ0541


(Methanocaldococcus
jannaschii)
PF01467
(CTP_transf_like)
4 TYR A  68
ILE A  31
ILE A  32
ILE A  23
None
0.94A 5murB-1f9aA:
undetectable
5murB-1f9aA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyb NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYLTRANSFERASE


(Methanothermobacter
thermautotrophicus)
PF01467
(CTP_transf_like)
4 TYR A  74
ILE A  34
ILE A  35
ILE A  26
None
0.91A 5murB-1hybA:
undetectable
5murB-1hybA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j7x INTERPHOTORECEPTOR
RETINOID-BINDING
PROTEIN


(Xenopus laevis)
PF03572
(Peptidase_S41)
PF11918
(Peptidase_S41_N)
4 TYR A 207
ILE A 145
ILE A 146
ILE A 138
None
0.93A 5murB-1j7xA:
undetectable
5murB-1j7xA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mgw GUANYL-SPECIFIC
RIBONUCLEASE SA3


(Kitasatospora
aureofaciens)
PF00545
(Ribonuclease)
4 TYR A  83
ILE A  74
ILE A  73
ILE A  25
None
None
None
LI  A 901 ( 4.4A)
0.93A 5murB-1mgwA:
undetectable
5murB-1mgwA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E


(Geobacillus
stearothermophilus)
PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M)
4 TYR A 105
ILE A 107
ILE A 106
ILE A 136
GOL  A 756 ( 3.8A)
None
None
None
0.91A 5murB-1mqqA:
4.1
5murB-1mqqA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pm2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
BETA CHAIN


(Escherichia
coli)
PF00268
(Ribonuc_red_sm)
4 TYR A 122
ILE A 125
ILE A 126
ILE A  74
None
0.63A 5murB-1pm2A:
2.7
5murB-1pm2A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwr MANNOSE-6-PHOSPHATE
ISOMERASE


(Bacillus
subtilis)
PF01238
(PMI_typeI)
4 TYR A 131
ILE A 157
ILE A 129
ILE A 120
None
0.89A 5murB-1qwrA:
0.0
5murB-1qwrA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sa3 TYPE II RESTRICTION
ENZYME MSPI


(Moraxella sp.)
PF09208
(Endonuc-MspI)
4 TYR A  37
ILE A  41
ILE A  38
ILE A 219
None
0.94A 5murB-1sa3A:
undetectable
5murB-1sa3A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE


(Escherichia
coli)
PF00291
(PALP)
PF00585
(Thr_dehydrat_C)
4 TYR A 299
ILE A 305
ILE A 300
ILE A  48
None
0.92A 5murB-1tdjA:
0.0
5murB-1tdjA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjx PUTATIVE
FERRITIN-LIKE
DIIRON-CARBOXYLATE
PROTEIN TM1526


(Thermotoga
maritima)
PF02915
(Rubrerythrin)
4 PRO A  76
ILE A  95
THR A  78
ILE A  81
None
0.90A 5murB-1vjxA:
4.0
5murB-1vjxA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y60 FORMALDEHYDE-ACTIVAT
ING ENZYME FAE


(Methylobacterium
extorquens)
PF08714
(Fae)
4 PRO A  64
ILE A 142
ILE A  27
THR A  66
None
0.81A 5murB-1y60A:
undetectable
5murB-1y60A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE


(Actinobacillus
succinogenes)
PF01293
(PEPCK_ATP)
4 ILE A 459
ILE A 458
THR A 441
ILE A 450
None
0.91A 5murB-1yggA:
undetectable
5murB-1yggA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE


(Saccharomyces
cerevisiae)
PF00343
(Phosphorylase)
4 TYR A 587
ILE A 584
ILE A 583
ILE A 623
None
0.88A 5murB-1ygpA:
undetectable
5murB-1ygpA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158


(Methanocaldococcus
jannaschii)
PF03841
(SelA)
4 TYR A  31
ILE A 328
ILE A 329
ILE A  17
None
0.94A 5murB-2aeuA:
undetectable
5murB-2aeuA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS


(Bacillus
subtilis)
PF02898
(NO_synthase)
4 ILE A 127
ILE A 213
THR A  97
ILE A 102
None
0.88A 5murB-2an2A:
undetectable
5murB-2an2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]


(Ogataea angusta)
PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer)
4 PRO A 449
TYR A 433
MET A 420
ILE A 469
None
0.89A 5murB-2bihA:
undetectable
5murB-2bihA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1


(Saccharomyces
cerevisiae)
PF00809
(Pterin_bind)
PF01288
(HPPK)
4 PRO A 756
ILE A 771
ILE A 774
ILE A 728
None
0.89A 5murB-2bmbA:
undetectable
5murB-2bmbA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE


(Homo sapiens)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
4 ILE A 179
ILE A 183
MET A 182
ILE A 261
None
0.82A 5murB-2c11A:
undetectable
5murB-2c11A:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5a GDP-MANNOSE-3',
5'-EPIMERASE


(Arabidopsis
thaliana)
PF01370
(Epimerase)
4 PRO A 321
ILE A 269
THR A 246
ILE A 204
None
None
None
NAD  A1378 (-4.3A)
0.93A 5murB-2c5aA:
undetectable
5murB-2c5aA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cry KIN OF IRRE-LIKE
PROTEIN 3


(Homo sapiens)
PF13927
(Ig_3)
4 ILE A 106
ILE A 107
THR A 104
ILE A  17
None
0.91A 5murB-2cryA:
undetectable
5murB-2cryA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzl 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE


(Escherichia
coli)
PF02542
(YgbB)
4 TYR A  27
ILE A  18
ILE A  25
ILE A  98
None
0.91A 5murB-2gzlA:
undetectable
5murB-2gzlA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN


(Thermotoga
maritima)
PF03480
(DctP)
4 TYR A 260
ILE A 263
ILE A 264
ILE A  59
None
0.73A 5murB-2hpgA:
undetectable
5murB-2hpgA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4c BICARBONATE
TRANSPORTER


(Synechocystis
sp. PCC 6803)
PF13379
(NMT1_2)
4 PRO A 224
ILE A  68
ILE A  66
THR A 192
None
BCT  A 460 (-4.5A)
None
BCT  A 460 (-2.7A)
0.91A 5murB-2i4cA:
undetectable
5murB-2i4cA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocd L-ASPARAGINASE I

(Vibrio cholerae)
PF00710
(Asparaginase)
4 TYR A   7
ILE A   8
ILE A   6
ILE A 113
None
0.93A 5murB-2ocdA:
undetectable
5murB-2ocdA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk9 ALPHA-TOXIN

(Clostridium
novyi)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
4 TYR A 459
ILE A 416
ILE A 456
ILE A 411
None
0.92A 5murB-2vk9A:
4.5
5murB-2vk9A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE


(Oceanicola
granulosus)
PF07555
(NAGidase)
5 ILE A 266
ILE A  26
MET A  31
THR A 253
ILE A 252
None
1.43A 5murB-2xsbA:
3.4
5murB-2xsbA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE


(Oceanicola
granulosus)
PF07555
(NAGidase)
5 PRO A 255
ILE A 266
MET A  31
THR A 253
ILE A 252
None
1.14A 5murB-2xsbA:
3.4
5murB-2xsbA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN


(Streptococcus
agalactiae)
PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3)
4 PRO A 195
TYR A 331
THR A 232
ILE A 305
None
0.80A 5murB-2xtlA:
3.5
5murB-2xtlA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqe JUMONJI/ARID
DOMAIN-CONTAINING
PROTEIN 1D


(Homo sapiens)
PF01388
(ARID)
4 TYR A 164
ILE A 161
ILE A 160
ILE A 102
None
0.87A 5murB-2yqeA:
undetectable
5murB-2yqeA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE


(Streptomyces
avermitilis)
PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2)
4 ILE A 139
ILE A  97
THR A 127
ILE A 130
None
0.71A 5murB-3a21A:
undetectable
5murB-3a21A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7f GLYCOSYL HYDROLASE,
BNR REPEAT


(Cupriavidus
pinatubonensis)
no annotation 4 TYR A 247
ILE A 267
ILE A 254
THR A 317
None
0.87A 5murB-3b7fA:
undetectable
5murB-3b7fA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg3 UPF0100 PROTEIN
PH0151


(Pyrococcus
horikoshii)
PF13531
(SBP_bac_11)
4 TYR A 195
MET A 163
THR A 273
ILE A 274
None
0.94A 5murB-3cg3A:
undetectable
5murB-3cg3A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE


(Colwellia
psychrerythraea)
PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C)
4 PRO A 179
TYR A 140
ILE A  95
ILE A 127
None
0.87A 5murB-3ciaA:
3.9
5murB-3ciaA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkx REPLICATION PROTEIN
REPB


(Streptococcus
agalactiae)
PF01719
(Rep_2)
4 TYR A  56
ILE A  35
MET A  33
ILE A  75
None
0.84A 5murB-3dkxA:
undetectable
5murB-3dkxA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA


(Methanocaldococcus
jannaschii)
PF00282
(Pyridoxal_deC)
4 TYR A 202
ILE A 203
ILE A 201
ILE A 126
None
0.93A 5murB-3f9tA:
undetectable
5murB-3f9tA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9m P-AMINOBENZOATE
SYNTHETASE,
COMPONENT I


(Cytophaga
hutchinsonii)
PF00425
(Chorismate_bind)
4 TYR A 186
ILE A 401
ILE A 184
ILE A 175
None
0.92A 5murB-3h9mA:
undetectable
5murB-3h9mA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2


(Streptococcus
mutans)
PF01791
(DeoC)
4 PRO A 105
TYR A 145
ILE A 149
ILE A 146
None
EDO  A 336 (-4.1A)
None
None
0.91A 5murB-3iv3A:
undetectable
5murB-3iv3A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2


(Streptococcus
pyogenes)
PF01791
(DeoC)
4 PRO A 101
TYR A 141
ILE A 145
ILE A 142
None
0.89A 5murB-3jrkA:
undetectable
5murB-3jrkA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv3 INTERSECTIN-1

(Mus musculus)
PF00621
(RhoGEF)
PF14604
(SH3_9)
4 TYR A1378
ILE A1381
ILE A1382
ILE A1308
None
0.94A 5murB-3jv3A:
4.1
5murB-3jv3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE


(Staphylococcus
aureus)
PF01791
(DeoC)
4 PRO A 105
TYR A 145
ILE A 149
ILE A 146
GOL  A 332 (-4.6A)
None
None
None
0.90A 5murB-3kaoA:
undetectable
5murB-3kaoA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens)
PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C)
4 TYR A 412
ILE A 403
ILE A 402
ILE A  93
None
0.91A 5murB-3kehA:
undetectable
5murB-3kehA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcm PUTATIVE
OXIDOREDUCTASE


(Streptococcus
mutans)
PF02525
(Flavodoxin_2)
4 ILE A  78
ILE A 125
THR A 185
ILE A 184
None
0.86A 5murB-3lcmA:
undetectable
5murB-3lcmA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myo TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 1


(Streptococcus
pyogenes)
PF01791
(DeoC)
4 PRO A 104
TYR A 144
ILE A 148
ILE A 145
None
0.88A 5murB-3myoA:
undetectable
5murB-3myoA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q87 N6 ADENINE SPECIFIC
DNA METHYLASE


(Encephalitozoon
cuniculi)
PF05175
(MTS)
4 PRO B 129
TYR B 157
ILE B 145
ILE B 159
None
0.87A 5murB-3q87B:
undetectable
5murB-3q87B:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qth UNCHARACTERIZED
PROTEIN


(Colwellia
psychrerythraea)
PF09351
(DUF1993)
4 PRO A 104
TYR A   8
ILE A   9
ILE A   5
None
0.91A 5murB-3qthA:
2.3
5murB-3qthA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4u PHND, SUBUNIT OF
ALKYLPHOSPHONATE ABC
TRANSPORTER


(Escherichia
coli)
PF12974
(Phosphonate-bd)
4 TYR A  47
ILE A  50
ILE A  51
MET A  54
None
0.94A 5murB-3s4uA:
2.5
5murB-3s4uA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upu ATP-DEPENDENT DNA
HELICASE DDA


(Escherichia
virus T4)
PF13604
(AAA_30)
4 PRO A 104
ILE A  84
THR A 131
ILE A 132
None
0.82A 5murB-3upuA:
undetectable
5murB-3upuA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2g 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
4 ILE A  96
ILE A 100
THR A  61
ILE A  86
None
0.76A 5murB-3v2gA:
undetectable
5murB-3v2gA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbj GALACTOSIDE
O-ACETYLTRANSFERASE


(Bacillus cereus)
PF00132
(Hexapep)
4 TYR A  90
ILE A 131
ILE A 132
ILE A  83
None
0.87A 5murB-3vbjA:
undetectable
5murB-3vbjA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
4 ILE A 423
ILE A 538
MET A 501
ILE A 545
None
0.93A 5murB-3wkyA:
undetectable
5murB-3wkyA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE


(Podospora
anserina)
PF02156
(Glyco_hydro_26)
PF16990
(CBM_35)
4 TYR A  65
ILE A  63
ILE A 122
THR A  74
None
0.92A 5murB-3zm8A:
undetectable
5murB-3zm8A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL


(Cavia porcellus)
PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C)
4 ILE A  83
ILE A  82
THR A 283
ILE A 282
None
0.91A 5murB-4bc7A:
undetectable
5murB-4bc7A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgu PROTEIN INTERACTING
WITH HSP90 1


(Saccharomyces
cerevisiae)
no annotation 4 PRO B 299
ILE B 329
ILE B 342
ILE B 316
PRO  B 299 ( 1.1A)
ILE  B 329 ( 0.7A)
ILE  B 342 ( 0.6A)
ILE  B 316 ( 0.7A)
0.94A 5murB-4cguB:
undetectable
5murB-4cguB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d70 SORTASE FAMILY
PROTEIN


(Clostridium
perfringens)
PF04203
(Sortase)
4 ILE A 168
ILE A 106
MET A 166
ILE A 132
None
0.88A 5murB-4d70A:
undetectable
5murB-4d70A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa)
PF01979
(Amidohydro_1)
4 TYR A 133
ILE A 110
ILE A 139
ILE A 118
None
0.89A 5murB-4dykA:
undetectable
5murB-4dykA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihq FLAI ATPASE

(Sulfolobus
acidocaldarius)
PF00437
(T2SSE)
4 TYR A 494
ILE A 495
THR A 232
ILE A 231
None
0.93A 5murB-4ihqA:
undetectable
5murB-4ihqA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT


(Acidaminococcus
fermentans)
PF00766
(ETF_alpha)
PF01012
(ETF)
4 TYR A  18
ILE A 106
MET A 166
ILE A  96
None
0.82A 5murB-4kpuA:
undetectable
5murB-4kpuA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr4 HYPOTHETICAL PROTEIN

([Eubacterium]
rectale)
no annotation 4 TYR A 185
ILE A 176
ILE A 184
ILE A 220
None
0.94A 5murB-4lr4A:
undetectable
5murB-4lr4A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER


(Proteus
mirabilis)
PF02028
(BCCT)
4 ILE A 235
ILE A 236
THR A 419
ILE A 423
None
0.61A 5murB-4m8jA:
2.4
5murB-4m8jA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqb THYMIDYLATE KINASE

(Staphylococcus
aureus)
PF02223
(Thymidylate_kin)
4 TYR A 167
ILE A 170
ILE A 171
THR A 128
None
0.93A 5murB-4mqbA:
undetectable
5murB-4mqbA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT


(Desulfovibrio
salexigens)
PF03480
(DctP)
4 TYR A 258
ILE A 261
ILE A 262
ILE A  66
None
0.71A 5murB-4n6kA:
undetectable
5murB-4n6kA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o87 N-TAGGED NUCLEASE

(Millerozyma
acaciae)
no annotation 5 PRO A   3
TYR A  83
ILE A  84
ILE A  80
THR A   5
None
1.15A 5murB-4o87A:
undetectable
5murB-4o87A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omj SEC14-LIKE PROTEIN 2

(Homo sapiens)
PF00650
(CRAL_TRIO)
4 TYR A 153
ILE A 151
ILE A 152
ILE A 258
2TX  A 310 (-4.3A)
2TX  A 310 ( 4.4A)
None
None
0.87A 5murB-4omjA:
undetectable
5murB-4omjA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE


(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
4 PRO A 304
TYR A 263
ILE A 216
ILE A 245
None
0.89A 5murB-4pj6A:
undetectable
5murB-4pj6A:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbl VRR-NUC

(Psychrobacter
sp. PRwf-1)
PF08774
(VRR_NUC)
4 TYR A  34
ILE A  78
ILE A  76
ILE A 129
None
0.91A 5murB-4qblA:
undetectable
5murB-4qblA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwo PROFILIN

(Monkeypox virus)
PF00235
(Profilin)
4 PRO A  60
ILE A  94
ILE A  96
ILE A  43
None
0.85A 5murB-4qwoA:
undetectable
5murB-4qwoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqv ALGM1

(Sphingomonas
sp.)
PF00528
(BPD_transp_1)
4 TYR A 204
ILE A 238
ILE A 208
ILE A 230
None
0.88A 5murB-4tqvA:
2.4
5murB-4tqvA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfs INTERLEUKIN-18

(Homo sapiens)
PF00340
(IL1)
4 PRO A  88
ILE A  48
THR A  63
ILE A  64
None
0.94A 5murB-4xfsA:
undetectable
5murB-4xfsA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
6 PRO A 120
ILE A 208
ILE A 209
MET A 212
THR A 262
ILE A 265
None
0.78A 5murB-4yeuA:
20.1
5murB-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
6 TYR A 204
ILE A 208
ILE A 209
MET A 212
THR A 262
ILE A 265
None
0.78A 5murB-4yeuA:
20.1
5murB-4yeuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyq FICIN ISOFORM A

(Ficus carica)
PF00112
(Peptidase_C1)
4 TYR A 111
ILE A  78
ILE A 108
ILE A  83
None
0.93A 5murB-4yyqA:
undetectable
5murB-4yyqA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE


(Saccharophagus
degradans)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
4 TYR A 360
ILE A 361
THR A 366
ILE A 365
None
0.91A 5murB-4zlgA:
2.7
5murB-4zlgA:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4m HYDROGENASE-1 SMALL
CHAIN


(Escherichia
coli)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
4 ILE S 159
ILE S 160
MET S 163
ILE S  72
None
0.84A 5murB-5a4mS:
undetectable
5murB-5a4mS:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum)
no annotation 4 ILE A 456
ILE A 452
THR A 476
ILE A 480
None
0.86A 5murB-5affA:
2.9
5murB-5affA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1r B-CELL
DIFFERENTIATION
ANTIGEN CD72


(Mus musculus)
no annotation 4 PRO A 283
TYR A 239
ILE A 237
ILE A 339
None
0.92A 5murB-5b1rA:
undetectable
5murB-5b1rA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT


(Sulfurisphaera
tokodaii)
PF01558
(POR)
PF01855
(POR_N)
4 ILE A 187
ILE A 190
THR A 173
ILE A 172
None
0.86A 5murB-5b48A:
undetectable
5murB-5b48A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110)
4 PRO A 204
TYR A 488
ILE A 584
ILE A 583
None
0.68A 5murB-5djwA:
undetectable
5murB-5djwA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA


(Escherichia
coli)
PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
5 PRO A 814
TYR A 833
ILE A 838
ILE A 835
ILE A 816
None
1.47A 5murB-5fkuA:
2.2
5murB-5fkuA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC98


(Saccharomyces
cerevisiae)
PF04130
(Spc97_Spc98)
4 TYR B 652
ILE B 656
ILE B 657
ILE B 586
None
0.88A 5murB-5flzB:
4.0
5murB-5flzB:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans)
PF01580
(FtsK_SpoIIIE)
4 TYR A 987
ILE A 973
ILE A1197
ILE A 999
None
0.93A 5murB-5fv0A:
undetectable
5murB-5fv0A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy0 GLUCANASE

(Ruminiclostridium
thermocellum)
PF00759
(Glyco_hydro_9)
PF00942
(CBM_3)
4 TYR A 511
ILE A 556
ILE A 558
ILE A 532
None
0.82A 5murB-5gy0A:
undetectable
5murB-5gy0A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh9 PVDN

(Pseudomonas
aeruginosa)
PF00266
(Aminotran_5)
4 TYR A 235
ILE A 233
ILE A 234
ILE A 141
None
0.87A 5murB-5hh9A:
undetectable
5murB-5hh9A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE


(Streptococcus
porcinus)
PF01791
(DeoC)
4 PRO A 104
TYR A 144
ILE A 148
ILE A 145
None
0.84A 5murB-5hjlA:
undetectable
5murB-5hjlA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix1 MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
3


(Mus musculus)
PF07496
(zf-CW)
PF13589
(HATPase_c_3)
5 ILE A 347
ILE A 315
MET A 317
THR A 370
ILE A 371
None
1.46A 5murB-5ix1A:
undetectable
5murB-5ix1A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8q CYSTEINE DESULFURASE
SUFS


(Bacillus
subtilis)
PF00266
(Aminotran_5)
4 ILE A   3
ILE A   6
MET A   1
ILE A 299
None
0.91A 5murB-5j8qA:
undetectable
5murB-5j8qA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum)
PF00232
(Glyco_hydro_1)
4 PRO A 173
TYR A 270
ILE A 214
ILE A 274
None
0.90A 5murB-5jboA:
undetectable
5murB-5jboA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li4 TAIL SHEATH PROTEIN

(Staphylococcus
phage 812)
no annotation 4 ILE A 525
ILE A 524
THR A 517
ILE A 518
None
0.87A 5murB-5li4A:
undetectable
5murB-5li4A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkc CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN (JO),CELL
WALL SURFACE ANCHOR
FAMILY PROTEIN (IN)


(Streptococcus
pneumoniae)
no annotation 4 TYR A 204
ILE A 193
ILE A 206
ILE A 715
None
0.94A 5murB-5mkcA:
2.7
5murB-5mkcA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol8 TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL


(Homo sapiens)
no annotation 4 TYR A 229
ILE A 171
ILE A 173
ILE A 219
None
0.87A 5murB-5ol8A:
undetectable
5murB-5ol8A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ola TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL


(Homo sapiens)
no annotation 4 TYR A 229
ILE A 171
ILE A 173
ILE A 219
None
0.86A 5murB-5olaA:
undetectable
5murB-5olaA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opg ENVELOPE
GLYCOPROTEIN GN


(Hantaan
orthohantavirus)
PF01567
(Hanta_G1)
4 TYR A 143
ILE A  41
ILE A 145
ILE A 246
None
0.91A 5murB-5opgA:
undetectable
5murB-5opgA:
12.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL


(Gloeobacter
violaceus)
no annotation 7 PRO C 120
TYR C 197
ILE C 201
ILE C 202
MET C 205
THR C 255
ILE C 258
None
0.44A 5murB-5v6nC:
36.0
5murB-5v6nC:
97.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1x MUTATOR MUTT PROTEIN

(Staphylococcus
aureus)
PF00293
(NUDIX)
4 PRO A  36
ILE A  11
ILE A  12
ILE A  54
None
0.78A 5murB-5x1xA:
undetectable
5murB-5x1xA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xz3 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN


(Apis mellifera)
no annotation 4 TYR A  33
ILE A 144
ILE A  35
ILE A 150
None
0.65A 5murB-5xz3A:
undetectable
5murB-5xz3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE


(Bacillus
licheniformis)
no annotation 4 PRO A  14
ILE A 278
THR A  25
ILE A  37
None
0.83A 5murB-6b7kA:
undetectable
5murB-6b7kA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE


(Methanosarcinales)
no annotation 4 TYR A 256
ILE A 291
ILE A 246
ILE A 299
None
0.91A 5murB-6c8zA:
undetectable
5murB-6c8zA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cud SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 3


(Homo sapiens)
no annotation 4 TYR A 774
ILE A 771
MET A 767
ILE A 274
None
0.91A 5murB-6cudA:
4.5
5murB-6cudA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT


(Influenza A
virus)
no annotation 4 TYR B 555
ILE B 552
THR B 527
ILE B 530
None
0.87A 5murB-6evjB:
undetectable
5murB-6evjB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1i -

(-)
no annotation 4 PRO A 222
ILE A 168
ILE A 169
ILE A 267
None
None
None
OHI  A 264 ( 4.0A)
0.84A 5murB-6g1iA:
undetectable
5murB-6g1iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 2,
MITOCHONDRIAL


(Mus musculus)
no annotation 4 TYR E  98
ILE E 156
ILE E 100
ILE E 169
None
0.90A 5murB-6g72E:
undetectable
5murB-6g72E:
20.99