SIMILAR PATTERNS OF AMINO ACIDS FOR 5MUO_D_PFLD402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knb ADENOVIRUS TYPE 5
FIBER PROTEIN

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob) 		5 THR A 535
SER A 553
ILE A 458
THR A 533
SER A 555
 None
 0.90A 5muoA-1knbA:
0.4
5muoB-1knbA:
undetectable
5muoC-1knbA:
0.5
5muoD-1knbA:
0.0
5muoE-1knbA:
0.0		 5muoA-1knbA:
20.22
5muoB-1knbA:
20.22
5muoC-1knbA:
20.22
5muoD-1knbA:
20.22
5muoE-1knbA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Drosophila
melanogaster;
Escherichia
coli) 		no annotation 5 SER P 597
SER P 601
SER P 714
ILE P 715
THR P 642
 None
 1.49A 5muoA-1r6zP:
0.0
5muoB-1r6zP:
undetectable
5muoC-1r6zP:
0.0
5muoD-1r6zP:
0.0
5muoE-1r6zP:
0.0		 5muoA-1r6zP:
10.17
5muoB-1r6zP:
10.17
5muoC-1r6zP:
10.17
5muoD-1r6zP:
10.17
5muoE-1r6zP:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtk COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		5 SER A 255
THR A 328
SER A 253
ILE A 256
THR A 330
 MG  A 749 (-2.4A)
MG  A 749 (-2.9A)
MG  A 749 (-2.3A)
None
None
 1.47A 5muoA-1rtkA:
0.0
5muoB-1rtkA:
0.0
5muoC-1rtkA:
0.0
5muoD-1rtkA:
0.0
5muoE-1rtkA:
0.0		 5muoA-1rtkA:
10.86
5muoB-1rtkA:
10.86
5muoC-1rtkA:
10.86
5muoD-1rtkA:
10.86
5muoE-1rtkA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zso HYPOTHETICAL PROTEIN

(Plasmodium
falciparum) 		PF05907
(DUF866) 		5 THR A  34
SER A  33
SER A  72
ILE A 104
THR A  66
 None
 1.44A 5muoA-1zsoA:
undetectable
5muoB-1zsoA:
0.0
5muoC-1zsoA:
0.0
5muoD-1zsoA:
undetectable
5muoE-1zsoA:
0.0		 5muoA-1zsoA:
16.67
5muoB-1zsoA:
16.67
5muoC-1zsoA:
16.67
5muoD-1zsoA:
16.67
5muoE-1zsoA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00266
(Aminotran_5) 		5 THR A 150
SER A 149
ILE A 344
THR A  94
THR A 144
 None
None
GLV  A1384 ( 4.3A)
None
PLP  A1201 (-4.3A)
 1.50A 5muoA-2bkwA:
0.0
5muoB-2bkwA:
0.0
5muoC-2bkwA:
0.0
5muoD-2bkwA:
0.0
5muoE-2bkwA:
0.0		 5muoA-2bkwA:
12.57
5muoB-2bkwA:
12.57
5muoC-2bkwA:
12.57
5muoD-2bkwA:
12.57
5muoE-2bkwA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4i AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		5 SER A 126
SER A  18
ILE A 256
THR A 117
THR A 114
 None
BTN  A1274 (-3.3A)
None
BTN  A1274 (-4.0A)
BTN  A1274 (-3.7A)
 1.48A 5muoA-2c4iA:
0.0
5muoB-2c4iA:
0.3
5muoC-2c4iA:
0.0
5muoD-2c4iA:
0.0
5muoE-2c4iA:
0.0		 5muoA-2c4iA:
12.92
5muoB-2c4iA:
12.92
5muoC-2c4iA:
12.92
5muoD-2c4iA:
12.92
5muoE-2c4iA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3k HAPTOGLOBIN-BINDING
SURFACE ANCHORED
PROTEIN

(Staphylococcus
aureus) 		PF05031
(NEAT) 		5 SER A 115
THR A 117
SER A  45
ILE A  65
THR A 130
 None
 1.46A 5muoA-2h3kA:
2.4
5muoB-2h3kA:
undetectable
5muoC-2h3kA:
2.4
5muoD-2h3kA:
0.0
5muoE-2h3kA:
2.4		 5muoA-2h3kA:
20.14
5muoB-2h3kA:
20.14
5muoC-2h3kA:
20.14
5muoD-2h3kA:
20.14
5muoE-2h3kA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE

(Rhodobacter
sphaeroides) 		PF00221
(Lyase_aromatic) 		5 THR A 331
SER A 113
ILE A 114
THR A 205
SER A 206
 None
 1.45A 5muoA-2o78A:
2.8
5muoB-2o78A:
2.9
5muoC-2o78A:
2.8
5muoD-2o78A:
2.8
5muoE-2o78A:
2.7		 5muoA-2o78A:
9.94
5muoB-2o78A:
9.94
5muoC-2o78A:
9.94
5muoD-2o78A:
9.94
5muoE-2o78A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 SER G1585
THR G1546
THR G1620
ILE G1579
THR G1642
 None
 1.43A 5muoA-2uv8G:
0.1
5muoB-2uv8G:
0.1
5muoC-2uv8G:
0.1
5muoD-2uv8G:
0.0
5muoE-2uv8G:
0.1		 5muoA-2uv8G:
3.30
5muoB-2uv8G:
3.30
5muoC-2uv8G:
3.30
5muoD-2uv8G:
3.30
5muoE-2uv8G:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xbl PHOSPHOHEPTOSE
ISOMERASE

(Burkholderia
pseudomallei) 		PF13580
(SIS_2) 		5 SER A  58
SER A 128
ILE A 131
SER A 125
THR A 171
 M7P  A1198 ( 4.2A)
M7P  A1198 (-2.5A)
None
M7P  A1198 (-2.6A)
M7P  A1198 (-3.7A)
 1.26A 5muoA-2xblA:
undetectable
5muoB-2xblA:
undetectable
5muoC-2xblA:
undetectable
5muoD-2xblA:
undetectable
5muoE-2xblA:
1.0		 5muoA-2xblA:
25.78
5muoB-2xblA:
25.78
5muoC-2xblA:
25.78
5muoD-2xblA:
25.78
5muoE-2xblA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX

(Escherichia
coli) 		PF03320
(FBPase_glpX) 		5 SER A 320
ILE A   7
THR A  13
SER A 281
THR A 283
 None
 1.43A 5muoA-3d1rA:
2.2
5muoB-3d1rA:
2.0
5muoC-3d1rA:
undetectable
5muoD-3d1rA:
undetectable
5muoE-3d1rA:
2.2		 5muoA-3d1rA:
13.10
5muoB-3d1rA:
13.10
5muoC-3d1rA:
13.10
5muoD-3d1rA:
13.10
5muoE-3d1rA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbq CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13786
(DUF4179) 		5 SER A 175
THR A 103
SER A  55
ILE A  48
THR A 105
 None
 1.15A 5muoA-3fbqA:
3.7
5muoB-3fbqA:
3.9
5muoC-3fbqA:
undetectable
5muoD-3fbqA:
undetectable
5muoE-3fbqA:
undetectable		 5muoA-3fbqA:
13.99
5muoB-3fbqA:
13.99
5muoC-3fbqA:
13.99
5muoD-3fbqA:
13.99
5muoE-3fbqA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbq CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13786
(DUF4179) 		5 THR A 103
SER A  55
ILE A  48
THR A 229
SER A 175
 None
 1.40A 5muoA-3fbqA:
3.7
5muoB-3fbqA:
3.9
5muoC-3fbqA:
undetectable
5muoD-3fbqA:
undetectable
5muoE-3fbqA:
undetectable		 5muoA-3fbqA:
13.99
5muoB-3fbqA:
13.99
5muoC-3fbqA:
13.99
5muoD-3fbqA:
13.99
5muoE-3fbqA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbq CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13786
(DUF4179) 		5 THR A 103
THR A  53
ILE A  48
THR A 229
SER A 175
 None
 1.36A 5muoA-3fbqA:
3.7
5muoB-3fbqA:
3.9
5muoC-3fbqA:
undetectable
5muoD-3fbqA:
undetectable
5muoE-3fbqA:
undetectable		 5muoA-3fbqA:
13.99
5muoB-3fbqA:
13.99
5muoC-3fbqA:
13.99
5muoD-3fbqA:
13.99
5muoE-3fbqA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbq CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13786
(DUF4179) 		5 THR A 229
SER A 175
THR A 103
SER A  55
THR A 105
 None
 1.31A 5muoA-3fbqA:
3.7
5muoB-3fbqA:
3.9
5muoC-3fbqA:
undetectable
5muoD-3fbqA:
undetectable
5muoE-3fbqA:
undetectable		 5muoA-3fbqA:
13.99
5muoB-3fbqA:
13.99
5muoC-3fbqA:
13.99
5muoD-3fbqA:
13.99
5muoE-3fbqA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzk PROTEIN TRANSPORT
PROTEIN SEC16

(Saccharomyces
cerevisiae) 		PF12931
(Sec16_C)
PF12932
(Sec16) 		5 THR B1308
SER B1311
SER B1302
THR B1273
SER B1277
 None
 1.49A 5muoA-3mzkB:
2.7
5muoB-3mzkB:
2.6
5muoC-3mzkB:
undetectable
5muoD-3mzkB:
undetectable
5muoE-3mzkB:
2.6		 5muoA-3mzkB:
13.61
5muoB-3mzkB:
13.61
5muoC-3mzkB:
13.61
5muoD-3mzkB:
13.61
5muoE-3mzkB:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9w PROLINE RACEMASE
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05544
(Pro_racemase) 		5 SER A  98
THR A  16
SER A   9
ILE A 290
THR A  11
 None
 1.12A 5muoA-4j9wA:
undetectable
5muoB-4j9wA:
undetectable
5muoC-4j9wA:
undetectable
5muoD-4j9wA:
undetectable
5muoE-4j9wA:
undetectable		 5muoA-4j9wA:
14.54
5muoB-4j9wA:
14.54
5muoC-4j9wA:
14.54
5muoD-4j9wA:
14.54
5muoE-4j9wA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE

(Leptospira
biflexa) 		PF00682
(HMGL-like) 		5 SER A 222
THR A 249
ILE A   6
THR A 244
THR A 208
 None
 1.34A 5muoA-4ov4A:
undetectable
5muoB-4ov4A:
undetectable
5muoC-4ov4A:
undetectable
5muoD-4ov4A:
undetectable
5muoE-4ov4A:
undetectable		 5muoA-4ov4A:
11.08
5muoB-4ov4A:
11.08
5muoC-4ov4A:
11.08
5muoD-4ov4A:
11.08
5muoE-4ov4A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yo0 HEAVY CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB
LIGHT CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 SER A 203
THR B 138
THR B 136
SER B 159
ILE B 194
 None
 1.05A 5muoA-4yo0A:
undetectable
5muoB-4yo0A:
2.2
5muoC-4yo0A:
undetectable
5muoD-4yo0A:
undetectable
5muoE-4yo0A:
undetectable		 5muoA-4yo0A:
14.35
5muoB-4yo0A:
14.35
5muoC-4yo0A:
14.35
5muoD-4yo0A:
14.35
5muoE-4yo0A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yo0 HEAVY CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB
LIGHT CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 THR B 138
THR B 136
SER B 159
ILE B 194
THR A 205
 None
 1.24A 5muoA-4yo0B:
undetectable
5muoB-4yo0B:
undetectable
5muoC-4yo0B:
undetectable
5muoD-4yo0B:
undetectable
5muoE-4yo0B:
undetectable		 5muoA-4yo0B:
16.13
5muoB-4yo0B:
16.13
5muoC-4yo0B:
16.13
5muoD-4yo0B:
16.13
5muoE-4yo0B:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum) 		PF02055
(Glyco_hydro_30) 		5 THR A 280
THR A  37
ILE A 265
THR A  33
SER A  31
 CL  A 617 (-4.8A)
None
None
P6G  A 624 (-3.2A)
P6G  A 624 (-3.4A)
 0.96A 5muoA-5cxpA:
undetectable
5muoB-5cxpA:
undetectable
5muoC-5cxpA:
undetectable
5muoD-5cxpA:
undetectable
5muoE-5cxpA:
undetectable		 5muoA-5cxpA:
12.98
5muoB-5cxpA:
12.98
5muoC-5cxpA:
12.98
5muoD-5cxpA:
12.98
5muoE-5cxpA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 THR H 140
SER H 183
THR L 126
THR L 124
SER L 147
 None
 0.95A 5muoA-5eorH:
undetectable
5muoB-5eorH:
undetectable
5muoC-5eorH:
undetectable
5muoD-5eorH:
undetectable
5muoE-5eorH:
undetectable		 5muoA-5eorH:
16.35
5muoB-5eorH:
16.35
5muoC-5eorH:
16.35
5muoD-5eorH:
16.35
5muoE-5eorH:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN

(Homo sapiens) 		no annotation 5 THR L  19
THR L  73
SER L  66
THR L  71
SER L  68
 None
 1.30A 5muoA-5ocyL:
undetectable
5muoB-5ocyL:
undetectable
5muoC-5ocyL:
undetectable
5muoD-5ocyL:
undetectable
5muoE-5ocyL:
undetectable		 5muoA-5ocyL:
27.96
5muoB-5ocyL:
27.96
5muoC-5ocyL:
27.96
5muoD-5ocyL:
27.96
5muoE-5ocyL:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		5 SER B  23
THR B 482
THR B  46
ILE B  17
SER B  51
 None
 1.32A 5muoA-5of4B:
2.5
5muoB-5of4B:
2.5
5muoC-5of4B:
undetectable
5muoD-5of4B:
undetectable
5muoE-5of4B:
2.5		 5muoA-5of4B:
7.76
5muoB-5of4B:
7.76
5muoC-5of4B:
7.76
5muoD-5of4B:
7.76
5muoE-5of4B:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulj RAI1

(Scheffersomyces
stipitis) 		PF08652
(RAI1) 		5 THR A 365
SER A 356
THR A 363
THR A 361
SER A 360
 None
 1.30A 5muoA-5uljA:
0.5
5muoB-5uljA:
0.5
5muoC-5uljA:
undetectable
5muoD-5uljA:
undetectable
5muoE-5uljA:
0.5		 5muoA-5uljA:
10.05
5muoB-5uljA:
10.05
5muoC-5uljA:
10.05
5muoD-5uljA:
10.05
5muoE-5uljA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vye L-THREONINE ALDOLASE

(Pseudomonas
putida) 		no annotation 5 THR A 150
THR A 146
ILE A 142
THR A  87
SER A  85
 None
 1.46A 5muoA-5vyeA:
undetectable
5muoB-5vyeA:
undetectable
5muoC-5vyeA:
undetectable
5muoD-5vyeA:
undetectable
5muoE-5vyeA:
undetectable		 5muoA-5vyeA:
18.82
5muoB-5vyeA:
18.82
5muoC-5vyeA:
18.82
5muoD-5vyeA:
18.82
5muoE-5vyeA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 5 THR A 251
SER A 248
THR A 236
SER A 240
ILE A 244
 None
 1.34A 5muoA-6es9A:
5.7
5muoB-6es9A:
5.6
5muoC-6es9A:
undetectable
5muoD-6es9A:
undetectable
5muoE-6es9A:
5.6		 5muoA-6es9A:
24.71
5muoB-6es9A:
24.71
5muoC-6es9A:
24.71
5muoD-6es9A:
24.71
5muoE-6es9A:
24.71