SIMILAR PATTERNS OF AMINO ACIDS FOR 5MUG_A_VIVA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		5 ILE A 341
ILE A 227
VAL A 260
LEU A 263
ILE A 186
 None
 1.01A 5mugA-1a2oA:
undetectable		 5mugA-1a2oA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2r CYTOCHROME C2

(Rhodobacter
capsulatus) 		no annotation 5 ILE A  57
LEU A 100
ILE A  72
VAL A 107
LEU A 111
 HEM  A 120 (-4.2A)
HEM  A 120 ( 4.2A)
HEM  A 120 ( 4.7A)
None
None
 1.03A 5mugA-1c2rA:
undetectable		 5mugA-1c2rA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czf POLYGALACTURONASE II

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		5 ILE A 260
LEU A 204
VAL A 241
VAL A 309
ILE A 306
 None
 1.05A 5mugA-1czfA:
undetectable		 5mugA-1czfA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		5 LEU A  83
ILE A  66
ILE A 128
LEU A  88
PHE A  43
 None
 0.93A 5mugA-1eb3A:
1.6		 5mugA-1eb3A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezr NUCLEOSIDE HYDROLASE

(Leishmania
major) 		PF01156
(IU_nuc_hydro) 		5 ILE A 132
ILE A   5
LEU A  30
VAL A  61
ILE A  33
 None
 1.09A 5mugA-1ezrA:
1.7		 5mugA-1ezrA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		5 VAL A 394
VAL A 141
LEU A 140
VAL A 401
PHE A 275
 None
 0.94A 5mugA-1f26A:
undetectable		 5mugA-1f26A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 ILE A 108
VAL A  31
ILE A 103
VAL A 209
LEU A 123
 None
 0.89A 5mugA-1fizA:
undetectable		 5mugA-1fizA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  39
VAL A  90
LEU A  59
VAL A  62
ILE A  79
 None
 0.96A 5mugA-1gq4A:
undetectable		 5mugA-1gq4A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu1 GAMMA1-ADAPTIN

(Homo sapiens) 		PF02883
(Alpha_adaptinC2) 		5 ILE A 707
LEU A 762
ILE A 778
ILE A 796
LEU A 798
 None
 0.92A 5mugA-1iu1A:
undetectable		 5mugA-1iu1A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqe HISTAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF13489
(Methyltransf_23) 		5 ILE A 139
ILE A 151
LEU A 155
PHE A 157
ILE A 170
 None
 0.68A 5mugA-1jqeA:
undetectable		 5mugA-1jqeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5l TRANSCRIPTIONAL
REGULATOR, CRP
FAMILY

(Thermotoga
maritima) 		PF00027
(cNMP_binding) 		5 ILE A  67
LEU A   7
ILE A  86
VAL A  12
PHE A  74
 None
 0.95A 5mugA-1o5lA:
undetectable		 5mugA-1o5lA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orr CDP-TYVELOSE-2-EPIME
RASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		5 ILE A  69
VAL A  65
LEU A  68
VAL A  55
ILE A  29
 None
 1.08A 5mugA-1orrA:
undetectable		 5mugA-1orrA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		5 ILE A 784
TRP A 689
VAL A 740
LEU A 741
ILE A 702
 None
 1.09A 5mugA-1p15A:
undetectable		 5mugA-1p15A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		5 ILE A 199
ILE A  57
LEU A  17
VAL A  88
ILE A 225
 None
 0.91A 5mugA-1pk9A:
undetectable		 5mugA-1pk9A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		5 ILE A 130
ILE A   6
LEU A  31
VAL A  61
ILE A  34
 None
 0.95A 5mugA-1q8fA:
1.7		 5mugA-1q8fA:
19.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		12 ILE A 119
VAL A 132
LEU A 137
ILE A 154
TRP A 163
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
ILE A 194
PHE A 203
 None
VIV  A 301 ( 4.7A)
VIV  A 301 ( 4.8A)
None
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
VIV  A 301 ( 4.5A)
None
 0.42A 5mugA-1r5lA:
37.0		 5mugA-1r5lA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli) 		PF00294
(PfkB) 		5 ILE A 184
ILE A 197
VAL A 211
VAL A 220
ILE A 222
 None
 0.83A 5mugA-1rk2A:
undetectable		 5mugA-1rk2A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Vibrio cholerae) 		PF12727
(PBP_like) 		5 VAL A 213
ILE A 107
LEU A 118
VAL A 137
ILE A 126
 None
 1.03A 5mugA-1twyA:
undetectable		 5mugA-1twyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		5 ILE A  17
LEU A  60
VAL A  76
LEU A  80
ILE A  44
 None
 0.93A 5mugA-1vpeA:
undetectable		 5mugA-1vpeA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		5 LEU A 143
ILE A  84
VAL A  77
ILE A  89
PHE A  68
 None
 1.09A 5mugA-1wkrA:
undetectable		 5mugA-1wkrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE

(Bos taurus) 		PF00587
(tRNA-synt_2b) 		5 LEU A 225
ILE A 473
ILE A 445
VAL A 458
ILE A 191
 None
 0.95A 5mugA-1wleA:
undetectable		 5mugA-1wleA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		5 ILE A 418
TRP A 390
VAL A 141
VAL A 110
ILE A 179
 None
 0.99A 5mugA-1wmrA:
undetectable		 5mugA-1wmrA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2

(Homo sapiens) 		PF00179
(UQ_con) 		5 ILE A  54
ILE A  88
LEU A  89
VAL A  67
ILE A 106
 None
 1.03A 5mugA-1y6lA:
undetectable		 5mugA-1y6lA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmr PHOSPHOGLYCERATE
KINASE

(Escherichia
coli) 		PF00162
(PGK) 		5 VAL A 112
LEU A  60
VAL A  77
LEU A  81
ILE A  44
 None
 1.04A 5mugA-1zmrA:
undetectable		 5mugA-1zmrA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pyrococcus
horikoshii) 		PF02540
(NAD_synthase) 		5 ILE A 153
ILE A 125
LEU A 127
VAL A  38
ILE A  17
 None
 1.09A 5mugA-2e18A:
undetectable		 5mugA-2e18A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew9 COPPER-TRANSPORTING
ATPASE 2

(Homo sapiens) 		PF00403
(HMA) 		5 ILE A  53
ILE A  22
LEU A  26
VAL A  32
ILE A  46
 None
 1.00A 5mugA-2ew9A:
undetectable		 5mugA-2ew9A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fph YLMH

(Streptococcus
pneumoniae) 		no annotation 5 ILE X 155
ILE X 108
LEU X 149
VAL X 157
ILE X  94
 None
 0.89A 5mugA-2fphX:
undetectable		 5mugA-2fphX:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2he4 NA(+)/H(+) EXCHANGE
REGULATORY COFACTOR
NHE-RF2

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A 176
VAL A 227
LEU A 196
VAL A 199
ILE A 216
 None
 1.00A 5mugA-2he4A:
undetectable		 5mugA-2he4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk0 D-PSICOSE
3-EPIMERASE

(Agrobacterium
tumefaciens) 		PF01261
(AP_endonuc_2) 		5 ILE A  40
ILE A 136
LEU A  93
VAL A  96
ILE A 104
 ILE  A  40 ( 0.7A)
ILE  A 136 ( 0.6A)
LEU  A  93 ( 0.6A)
VAL  A  96 ( 0.6A)
ILE  A 104 ( 0.7A)
 1.08A 5mugA-2hk0A:
1.7		 5mugA-2hk0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE

(Crithidia
fasciculata) 		PF01156
(IU_nuc_hydro) 		5 ILE A 132
ILE A   5
LEU A  30
VAL A  61
ILE A  33
 None
 1.08A 5mugA-2masA:
1.8		 5mugA-2masA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmz DNA-DIRECTED RNA
POLYMERASE SUBUNIT L

(Sulfolobus
solfataricus) 		PF13656
(RNA_pol_L_2) 		5 ILE L  63
ILE L  28
LEU L  32
VAL L  38
ILE L  57
 None
 0.95A 5mugA-2pmzL:
undetectable		 5mugA-2pmzL:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm3 PREDICTED
METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF01861
(DUF43) 		5 LEU A  76
ILE A  51
LEU A  52
VAL A  67
ILE A  37
 None
 0.92A 5mugA-2qm3A:
2.2		 5mugA-2qm3A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 LEU A 686
ILE A  95
VAL A 695
LEU A 698
VAL A  90
 None
 1.09A 5mugA-2v26A:
undetectable		 5mugA-2v26A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3c SIGNAL RECOGNITION
54 KDA PROTEIN

(Methanocaldococcus
jannaschii) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 ILE C 154
LEU C  93
ILE C 186
LEU C 105
VAL C 218
 None
 0.97A 5mugA-2v3cC:
undetectable		 5mugA-2v3cC:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1j PUTATIVE SORTASE

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		5 ILE A  22
LEU A 105
ILE A 128
LEU A 190
ILE A  87
 None
 0.93A 5mugA-2w1jA:
undetectable		 5mugA-2w1jA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2weu TRYPTOPHAN
5-HALOGENASE

(Streptomyces
rugosporus) 		PF04820
(Trp_halogenase) 		5 ILE A   2
LEU A  33
LEU A 232
VAL A 198
ILE A 206
 None
 1.04A 5mugA-2weuA:
undetectable		 5mugA-2weuA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wia FERROUS IRON
TRANSPORT PROTEIN B

(Klebsiella
pneumoniae) 		PF02421
(FeoB_N) 		5 VAL A 175
LEU A 172
ILE A 255
LEU A 137
VAL A 145
 None
 1.04A 5mugA-2wiaA:
undetectable		 5mugA-2wiaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 368
ILE A 227
TRP A 296
ILE A  89
VAL A 178
 None
None
FOM  A 701 (-3.8A)
NDP  A 501 (-4.4A)
None
 1.05A 5mugA-3au9A:
2.1		 5mugA-3au9A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbx DISHEVELLED-2

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A 294
ILE A 347
VAL A 320
LEU A 349
ILE A 280
 None
 0.92A 5mugA-3cbxA:
undetectable		 5mugA-3cbxA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d12 EPHRIN-B3

(Mus musculus) 		PF00812
(Ephrin) 		5 VAL B 167
LEU B  50
ILE B 138
ILE B 115
LEU B 101
 None
 1.10A 5mugA-3d12B:
undetectable		 5mugA-3d12B:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dip ENOLASE

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 389
VAL A 359
LEU A 382
VAL A 386
ILE A  10
 None
 1.02A 5mugA-3dipA:
3.1		 5mugA-3dipA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE

(Brucella
abortus) 		PF00171
(Aldedh) 		5 ILE A  21
ILE A 217
LEU A 221
VAL A 227
ILE A 179
 None
 0.88A 5mugA-3ek1A:
undetectable		 5mugA-3ek1A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1

(Candida
parapsilosis) 		PF00026
(Asp) 		5 VAL A  20
ILE A   8
ILE A  95
LEU A   5
ILE A  31
 None
 0.95A 5mugA-3fv3A:
undetectable		 5mugA-3fv3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxq LYSR TYPE REGULATOR
OF TSAMBCD

(Comamonas
testosteroni) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		5 ILE A 270
ILE A  94
LEU A 111
PHE A 118
VAL A 123
 None
 0.93A 5mugA-3fxqA:
undetectable		 5mugA-3fxqA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 LEU A 827
ILE A 783
VAL A 781
LEU A 760
VAL A 700
 None
 1.02A 5mugA-3h09A:
undetectable		 5mugA-3h09A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h14 AMINOTRANSFERASE,
CLASSES I AND II

(Ruegeria
pomeroyi) 		PF00155
(Aminotran_1_2) 		5 ILE A 202
ILE A 131
LEU A 132
VAL A 118
ILE A 120
 None
 1.02A 5mugA-3h14A:
undetectable		 5mugA-3h14A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		5 ILE M 215
ILE M 301
VAL M 173
LEU M 176
VAL M 302
 None
 1.02A 5mugA-3i04M:
undetectable		 5mugA-3i04M:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iby FERROUS IRON
TRANSPORT PROTEIN B

(Legionella
pneumophila) 		PF02421
(FeoB_N) 		5 VAL A 250
ILE A 168
ILE A  91
VAL A 143
VAL A 113
 None
 1.10A 5mugA-3ibyA:
undetectable		 5mugA-3ibyA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig4 XAA-PRO
AMINOPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 LEU A 229
ILE A 191
VAL A 194
LEU A 195
ILE A 408
 None
 0.69A 5mugA-3ig4A:
undetectable		 5mugA-3ig4A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8e D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE

(Escherichia
coli) 		PF13242
(Hydrolase_like) 		5 LEU A 173
ILE A  32
ILE A   8
VAL A 134
LEU A  10
 None
 1.09A 5mugA-3l8eA:
undetectable		 5mugA-3l8eA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me8 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aquifex
aeolicus) 		PF02630
(SCO1-SenC) 		5 ILE A  90
LEU A 133
ILE A 143
ILE A  47
PHE A  84
 None
 1.01A 5mugA-3me8A:
undetectable		 5mugA-3me8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7z ACETYLTRANSFERASE,
GNAT FAMILY

(Bacillus
anthracis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 ILE A 328
ILE A 372
ILE A 309
LEU A 341
ILE A 349
 None
 1.08A 5mugA-3n7zA:
undetectable		 5mugA-3n7zA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Salmonella
enterica) 		PF00290
(Trp_syntA) 		5 ILE A 237
ILE A  97
LEU A  50
VAL A  23
ILE A  37
 None
 1.04A 5mugA-3pr2A:
1.7		 5mugA-3pr2A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3q ALKALINE PHOSPHATASE

(Sphingomonas
sp. BSAR-1) 		PF01663
(Phosphodiest) 		5 ILE A 292
LEU A  67
ILE A 503
PHE A  56
ILE A  96
 None
 0.86A 5mugA-3q3qA:
undetectable		 5mugA-3q3qA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r67 PUTATIVE GLYCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		5 ILE A 280
VAL A 232
LEU A 238
VAL A 154
ILE A 214
 None
 1.02A 5mugA-3r67A:
undetectable		 5mugA-3r67A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		5 ILE A 122
ILE A 188
LEU A 185
VAL A 216
ILE A 199
 None
 1.09A 5mugA-3rjyA:
1.8		 5mugA-3rjyA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		5 ILE A 247
LEU A 271
VAL A 276
ILE A 279
PHE A 286
 None
 0.92A 5mugA-3t6qA:
undetectable		 5mugA-3t6qA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		5 ILE A 299
VAL A  94
ILE A  67
LEU A  63
VAL A 228
 None
 0.97A 5mugA-3tsyA:
undetectable		 5mugA-3tsyA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2p RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 VAL A 391
ILE A 447
ILE A 417
LEU A 441
ILE A 435
 None
 0.99A 5mugA-3u2pA:
undetectable		 5mugA-3u2pA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwd PHOSPHOGLYCERATE
KINASE

(Bacillus
anthracis) 		PF00162
(PGK) 		5 VAL A 117
LEU A  60
VAL A  76
LEU A  80
ILE A  44
 None
 1.06A 5mugA-3uwdA:
undetectable		 5mugA-3uwdA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhc PHYTASE

(Citrobacter
braakii) 		PF00328
(His_Phos_2) 		5 ILE A 299
VAL A  12
LEU A 297
VAL A 294
ILE A 290
 None
 0.95A 5mugA-3zhcA:
undetectable		 5mugA-3zhcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zto NUCLEOSIDE
DIPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00334
(NDK) 		5 ILE A  89
ILE A  34
LEU A  77
VAL A  86
ILE A   8
 None
 0.74A 5mugA-3ztoA:
undetectable		 5mugA-3ztoA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2

(Mus musculus) 		PF07528
(DZF) 		5 ILE A 128
VAL A 135
LEU A 138
VAL A  97
ILE A  99
 None
 0.75A 5mugA-4atbA:
undetectable		 5mugA-4atbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkf EPHRIN-B3

(Homo sapiens) 		PF00812
(Ephrin) 		5 VAL C 167
LEU C  50
ILE C 138
ILE C 115
LEU C 101
 None
 1.10A 5mugA-4bkfC:
undetectable		 5mugA-4bkfC:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmb GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 ILE A 105
ILE A  23
LEU A 138
PHE A  64
ILE A 149
 None
 1.07A 5mugA-4bmbA:
undetectable		 5mugA-4bmbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus) 		PF00793
(DAHP_synth_1) 		5 LEU A  46
ILE A 224
VAL A 228
LEU A 243
ILE A 210
 None
 0.96A 5mugA-4c1lA:
undetectable		 5mugA-4c1lA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dib GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A  12
VAL A 322
ILE A  71
VAL A  66
ILE A  44
 None
 0.93A 5mugA-4dibA:
undetectable		 5mugA-4dibA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grs PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE,
2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus;
Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 LEU A 117
ILE A 295
VAL A 299
LEU A 314
ILE A 281
 None
 0.95A 5mugA-4grsA:
undetectable		 5mugA-4grsA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxi KELCH-LIKE PROTEIN 3

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE A  93
VAL A  96
LEU A 101
ILE A 105
PHE A  79
 None
 0.98A 5mugA-4hxiA:
undetectable		 5mugA-4hxiA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis) 		PF00005
(ABC_tran) 		5 LEU A  49
ILE A  83
VAL A  64
LEU A  71
VAL A  79
 None
 1.04A 5mugA-4hzuA:
undetectable		 5mugA-4hzuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 ILE A 234
ILE A 214
LEU A 210
VAL A 237
ILE A 206
 None
 1.09A 5mugA-4jcmA:
2.2		 5mugA-4jcmA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng4 PHOSPHOGLYCERATE
KINASE

(Coxiella
burnetii) 		PF00162
(PGK) 		5 VAL A 115
LEU A  63
VAL A  80
LEU A  84
ILE A  47
 None
 0.99A 5mugA-4ng4A:
undetectable		 5mugA-4ng4A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0c NA(+)/H(+) EXCHANGE
REGULATORY COFACTOR
NHE-RF2/LYSOPHOSPHAT
IDIC ACID RECEPTOR 2
CHIMERIC PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  36
VAL A  87
LEU A  56
VAL A  59
ILE A  76
 None
 1.00A 5mugA-4p0cA:
undetectable		 5mugA-4p0cA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum pratense) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 VAL A 204
ILE A  79
LEU A 106
VAL A 104
ILE A  65
 None
None
FAD  A 601 (-4.8A)
None
None
 0.90A 5mugA-4pveA:
undetectable		 5mugA-4pveA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2n INAD-LIKE PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 VAL A 434
VAL A 445
LEU A 368
VAL A 366
ILE A 412
 None
 1.03A 5mugA-4q2nA:
undetectable		 5mugA-4q2nA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE

(Leishmania
major) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ILE A 407
VAL A 200
ILE A 307
ILE A 233
VAL A 296
 None
 0.63A 5mugA-4qg5A:
undetectable		 5mugA-4qg5A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 ILE A  41
ILE A 247
ILE A 241
LEU A 243
ILE A  26
 None
 1.01A 5mugA-4r6lA:
undetectable		 5mugA-4r6lA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8v CRISPR SYSTEM CMR
SUBUNIT CMR6

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		5 ILE A 226
LEU A 203
LEU A 320
VAL A 325
ILE A 149
 None
 1.03A 5mugA-4w8vA:
undetectable		 5mugA-4w8vA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvw GALECTIN

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		5 ILE A 104
ILE A  22
LEU A 137
PHE A  63
ILE A 148
 None
 1.06A 5mugA-4wvwA:
undetectable		 5mugA-4wvwA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x54 OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella ovis) 		PF13561
(adh_short_C2) 		5 VAL A 161
ILE A  75
LEU A  79
VAL A  77
ILE A  85
 None
 0.95A 5mugA-4x54A:
2.2		 5mugA-4x54A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x REELIN

(Mus musculus) 		PF07974
(EGF_2) 		5 LEU A2563
ILE A2661
VAL A2659
VAL A2624
ILE A2626
 None
 1.09A 5mugA-5b4xA:
undetectable		 5mugA-5b4xA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 ILE A 583
ILE A 711
ILE A 685
LEU A 669
ILE A 637
 None
 0.89A 5mugA-5bs5A:
undetectable		 5mugA-5bs5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt8 PHOSPHOGLYCERATE
KINASE

(Acinetobacter
baumannii) 		PF00162
(PGK) 		5 VAL A 112
LEU A  60
VAL A  77
LEU A  81
ILE A  44
 None
 1.05A 5mugA-5bt8A:
undetectable		 5mugA-5bt8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		5 LEU B 157
ILE B 192
VAL B 225
LEU B 228
VAL B 191
 None
 1.05A 5mugA-5do7B:
undetectable		 5mugA-5do7B:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elz TYPE II PANTOTHENATE
KINASE

(Staphylococcus
aureus) 		PF03630
(Fumble) 		5 ILE A  32
ILE A  63
LEU A  39
VAL A  35
ILE A   5
 None
 1.08A 5mugA-5elzA:
undetectable		 5mugA-5elzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsy MACRODOMAIN

(Trypanosoma
brucei) 		PF01661
(Macro) 		5 ILE A 192
VAL A 209
LEU A 218
VAL A 260
ILE A 102
 None
AR6  A1262 ( 4.5A)
None
None
None
 0.76A 5mugA-5fsyA:
undetectable		 5mugA-5fsyA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmk PRE-MRNA-SPLICING
FACTOR CWC22

(Saccharomyces
cerevisiae) 		PF02847
(MA3) 		5 VAL Z  61
ILE Z  21
LEU Z  44
VAL Z  47
ILE Z  49
 None
 1.07A 5mugA-5gmkZ:
undetectable		 5mugA-5gmkZ:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzg GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 ILE A 105
ILE A  23
LEU A 138
PHE A  64
ILE A 149
 None
 1.08A 5mugA-5gzgA:
undetectable		 5mugA-5gzgA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA

(Geobacillus
stearothermophilus) 		no annotation 5 ILE B 114
ILE B  71
LEU B  74
VAL B  76
ILE B 131
 None
 1.09A 5mugA-5ivlB:
undetectable		 5mugA-5ivlB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		5 VAL A 112
ILE A 552
ILE A 109
LEU A  97
VAL A 553
 None
 1.04A 5mugA-5mq6A:
undetectable		 5mugA-5mq6A:
17.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		12 ILE A 119
VAL A 132
LEU A 137
ILE A 154
TRP A 163
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
ILE A 194
PHE A 203
 None
VIV  A 302 (-4.4A)
VIV  A 302 ( 4.8A)
None
None
VIV  A 302 (-4.0A)
VIV  A 302 (-4.4A)
None
VIV  A 302 (-4.0A)
VIV  A 302 ( 4.9A)
VIV  A 302 ( 4.6A)
None
 0.31A 5mugA-5mueA:
39.4		 5mugA-5mueA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oom 39S RIBOSOMAL
PROTEIN L22,
MITOCHONDRIAL

(Homo sapiens) 		PF00237
(Ribosomal_L22) 		5 ILE T  73
ILE T 117
VAL T 120
LEU T 121
ILE T 142
 None
 1.03A 5mugA-5oomT:
undetectable		 5mugA-5oomT:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 5 ILE B 267
VAL B 328
VAL B 189
LEU B 190
ILE B 202
 None
 0.85A 5mugA-5txrB:
undetectable		 5mugA-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s DNA REPLICATION
LICENSING FACTOR
MCM4

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 LEU 4 544
ILE 4 671
ILE 4 577
VAL 4 581
LEU 4 578
 None
 0.96A 5mugA-5u8s4:
undetectable		 5mugA-5u8s4:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7f UGGT

(Thermomyces
dupontii) 		PF01501
(Glyco_transf_8) 		5 ILE A1350
LEU A1311
ILE A1399
LEU A1279
ILE A1276
 None
 1.04A 5mugA-5y7fA:
undetectable		 5mugA-5y7fA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		no annotation 5 ILE A 109
VAL A 208
ILE A  74
VAL A  76
PHE A  85
 None
 0.79A 5mugA-5yt0A:
undetectable		 5mugA-5yt0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zby HYDROGENASE
MATURATION PROTEASE
HYCI

(Thermococcus
kodakarensis) 		no annotation 5 ILE A  87
ILE A 154
LEU A 155
VAL A  46
ILE A  16
 None
 0.77A 5mugA-5zbyA:
undetectable		 5mugA-5zbyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 5 ILE A  14
VAL A  51
LEU A  54
VAL A  13
PHE A  70
 None
 0.92A 5mugA-6bfiA:
undetectable		 5mugA-6bfiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A 389
VAL A 374
LEU A 377
VAL A 419
ILE A 137
 None
 0.93A 5mugA-6c26A:
undetectable		 5mugA-6c26A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpe ATPASE YJEE,
PREDICTED TO HAVE
ESSENTIAL ROLE IN
CELL WALL
BIOSYNTHESIS

(Thermotoga
maritima) 		no annotation 5 ILE E 104
ILE E 126
LEU E  17
VAL E 136
ILE E 138
 None
 1.05A 5mugA-6fpeE:
undetectable		 5mugA-6fpeE:
undetectable