SIMILAR PATTERNS OF AMINO ACIDS FOR 5MUG_A_VIVA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		5 ILE A 341
ILE A 227
VAL A 260
LEU A 263
ILE A 186
 None
 1.01A 5mugA-1a2oA:
undetectable		 5mugA-1a2oA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2r CYTOCHROME C2

(Rhodobacter
capsulatus) 		no annotation 5 ILE A  57
LEU A 100
ILE A  72
VAL A 107
LEU A 111
 HEM  A 120 (-4.2A)
HEM  A 120 ( 4.2A)
HEM  A 120 ( 4.7A)
None
None
 1.03A 5mugA-1c2rA:
undetectable		 5mugA-1c2rA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czf POLYGALACTURONASE II

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		5 ILE A 260
LEU A 204
VAL A 241
VAL A 309
ILE A 306
 None
 1.05A 5mugA-1czfA:
undetectable		 5mugA-1czfA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		5 LEU A  83
ILE A  66
ILE A 128
LEU A  88
PHE A  43
 None
 0.93A 5mugA-1eb3A:
1.6		 5mugA-1eb3A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezr NUCLEOSIDE HYDROLASE

(Leishmania
major) 		PF01156
(IU_nuc_hydro) 		5 ILE A 132
ILE A   5
LEU A  30
VAL A  61
ILE A  33
 None
 1.09A 5mugA-1ezrA:
1.7		 5mugA-1ezrA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		5 VAL A 394
VAL A 141
LEU A 140
VAL A 401
PHE A 275
 None
 0.94A 5mugA-1f26A:
undetectable		 5mugA-1f26A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 ILE A 108
VAL A  31
ILE A 103
VAL A 209
LEU A 123
 None
 0.89A 5mugA-1fizA:
undetectable		 5mugA-1fizA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  39
VAL A  90
LEU A  59
VAL A  62
ILE A  79
 None
 0.96A 5mugA-1gq4A:
undetectable		 5mugA-1gq4A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu1 GAMMA1-ADAPTIN

(Homo sapiens) 		PF02883
(Alpha_adaptinC2) 		5 ILE A 707
LEU A 762
ILE A 778
ILE A 796
LEU A 798
 None
 0.92A 5mugA-1iu1A:
undetectable		 5mugA-1iu1A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqe HISTAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF13489
(Methyltransf_23) 		5 ILE A 139
ILE A 151
LEU A 155
PHE A 157
ILE A 170
 None
 0.68A 5mugA-1jqeA:
undetectable		 5mugA-1jqeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5l TRANSCRIPTIONAL
REGULATOR, CRP
FAMILY

(Thermotoga
maritima) 		PF00027
(cNMP_binding) 		5 ILE A  67
LEU A   7
ILE A  86
VAL A  12
PHE A  74
 None
 0.95A 5mugA-1o5lA:
undetectable		 5mugA-1o5lA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orr CDP-TYVELOSE-2-EPIME
RASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		5 ILE A  69
VAL A  65
LEU A  68
VAL A  55
ILE A  29
 None
 1.08A 5mugA-1orrA:
undetectable		 5mugA-1orrA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		5 ILE A 784
TRP A 689
VAL A 740
LEU A 741
ILE A 702
 None
 1.09A 5mugA-1p15A:
undetectable		 5mugA-1p15A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		5 ILE A 199
ILE A  57
LEU A  17
VAL A  88
ILE A 225
 None
 0.91A 5mugA-1pk9A:
undetectable		 5mugA-1pk9A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		5 ILE A 130
ILE A   6
LEU A  31
VAL A  61
ILE A  34
 None
 0.95A 5mugA-1q8fA:
1.7		 5mugA-1q8fA:
19.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		12 ILE A 119
VAL A 132
LEU A 137
ILE A 154
TRP A 163
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
ILE A 194
PHE A 203
 None
VIV  A 301 ( 4.7A)
VIV  A 301 ( 4.8A)
None
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
VIV  A 301 ( 4.5A)
None
 0.42A 5mugA-1r5lA:
37.0		 5mugA-1r5lA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli) 		PF00294
(PfkB) 		5 ILE A 184
ILE A 197
VAL A 211
VAL A 220
ILE A 222
 None
 0.83A 5mugA-1rk2A:
undetectable		 5mugA-1rk2A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Vibrio cholerae) 		PF12727
(PBP_like) 		5 VAL A 213
ILE A 107
LEU A 118
VAL A 137
ILE A 126
 None
 1.03A 5mugA-1twyA:
undetectable		 5mugA-1twyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		5 ILE A  17
LEU A  60
VAL A  76
LEU A  80
ILE A  44
 None
 0.93A 5mugA-1vpeA:
undetectable		 5mugA-1vpeA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		5 LEU A 143
ILE A  84
VAL A  77
ILE A  89
PHE A  68
 None
 1.09A 5mugA-1wkrA:
undetectable		 5mugA-1wkrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE

(Bos taurus) 		PF00587
(tRNA-synt_2b) 		5 LEU A 225
ILE A 473
ILE A 445
VAL A 458
ILE A 191
 None
 0.95A 5mugA-1wleA:
undetectable		 5mugA-1wleA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		5 ILE A 418
TRP A 390
VAL A 141
VAL A 110
ILE A 179
 None
 0.99A 5mugA-1wmrA:
undetectable		 5mugA-1wmrA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2

(Homo sapiens) 		PF00179
(UQ_con) 		5 ILE A  54
ILE A  88
LEU A  89
VAL A  67
ILE A 106
 None
 1.03A 5mugA-1y6lA:
undetectable		 5mugA-1y6lA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmr PHOSPHOGLYCERATE
KINASE

(Escherichia
coli) 		PF00162
(PGK) 		5 VAL A 112
LEU A  60
VAL A  77
LEU A  81
ILE A  44
 None
 1.04A 5mugA-1zmrA:
undetectable		 5mugA-1zmrA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pyrococcus
horikoshii) 		PF02540
(NAD_synthase) 		5 ILE A 153
ILE A 125
LEU A 127
VAL A  38
ILE A  17
 None
 1.09A 5mugA-2e18A:
undetectable		 5mugA-2e18A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew9 COPPER-TRANSPORTING
ATPASE 2

(Homo sapiens) 		PF00403
(HMA) 		5 ILE A  53
ILE A  22
LEU A  26
VAL A  32
ILE A  46
 None
 1.00A 5mugA-2ew9A:
undetectable		 5mugA-2ew9A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fph YLMH

(Streptococcus
pneumoniae) 		no annotation 5 ILE X 155
ILE X 108
LEU X 149
VAL X 157
ILE X  94
 None
 0.89A 5mugA-2fphX:
undetectable		 5mugA-2fphX:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2he4 NA(+)/H(+) EXCHANGE
REGULATORY COFACTOR
NHE-RF2

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A 176
VAL A 227
LEU A 196
VAL A 199
ILE A 216
 None
 1.00A 5mugA-2he4A:
undetectable		 5mugA-2he4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk0 D-PSICOSE
3-EPIMERASE

(Agrobacterium
tumefaciens) 		PF01261
(AP_endonuc_2) 		5 ILE A  40
ILE A 136
LEU A  93
VAL A  96
ILE A 104
 ILE  A  40 ( 0.7A)
ILE  A 136 ( 0.6A)
LEU  A  93 ( 0.6A)
VAL  A  96 ( 0.6A)
ILE  A 104 ( 0.7A)
 1.08A 5mugA-2hk0A:
1.7		 5mugA-2hk0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE

(Crithidia
fasciculata) 		PF01156
(IU_nuc_hydro) 		5 ILE A 132
ILE A   5
LEU A  30
VAL A  61
ILE A  33
 None
 1.08A 5mugA-2masA:
1.8		 5mugA-2masA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmz DNA-DIRECTED RNA
POLYMERASE SUBUNIT L

(Sulfolobus
solfataricus) 		PF13656
(RNA_pol_L_2) 		5 ILE L  63
ILE L  28
LEU L  32
VAL L  38
ILE L  57
 None
 0.95A 5mugA-2pmzL:
undetectable		 5mugA-2pmzL:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm3 PREDICTED
METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF01861
(DUF43) 		5 LEU A  76
ILE A  51
LEU A  52
VAL A  67
ILE A  37
 None
 0.92A 5mugA-2qm3A:
2.2		 5mugA-2qm3A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 LEU A 686
ILE A  95
VAL A 695
LEU A 698
VAL A  90
 None
 1.09A 5mugA-2v26A:
undetectable		 5mugA-2v26A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3c SIGNAL RECOGNITION
54 KDA PROTEIN

(Methanocaldococcus
jannaschii) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 ILE C 154
LEU C  93
ILE C 186
LEU C 105
VAL C 218
 None
 0.97A 5mugA-2v3cC:
undetectable		 5mugA-2v3cC:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1j PUTATIVE SORTASE

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		5 ILE A  22
LEU A 105
ILE A 128
LEU A 190
ILE A  87
 None
 0.93A 5mugA-2w1jA:
undetectable		 5mugA-2w1jA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2weu TRYPTOPHAN
5-HALOGENASE

(Streptomyces
rugosporus) 		PF04820
(Trp_halogenase) 		5 ILE A   2
LEU A  33
LEU A 232
VAL A 198
ILE A 206
 None
 1.04A 5mugA-2weuA:
undetectable		 5mugA-2weuA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wia FERROUS IRON
TRANSPORT PROTEIN B

(Klebsiella
pneumoniae) 		PF02421
(FeoB_N) 		5 VAL A 175
LEU A 172
ILE A 255
LEU A 137
VAL A 145
 None
 1.04A 5mugA-2wiaA:
undetectable		 5mugA-2wiaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 368
ILE A 227
TRP A 296
ILE A  89
VAL A 178
 None
None
FOM  A 701 (-3.8A)
NDP  A 501 (-4.4A)
None
 1.05A 5mugA-3au9A:
2.1		 5mugA-3au9A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbx DISHEVELLED-2

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A 294
ILE A 347
VAL A 320
LEU A 349
ILE A 280
 None
 0.92A 5mugA-3cbxA:
undetectable		 5mugA-3cbxA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d12 EPHRIN-B3

(Mus musculus) 		PF00812
(Ephrin) 		5 VAL B 167
LEU B  50
ILE B 138
ILE B 115
LEU B 101
 None
 1.10A 5mugA-3d12B:
undetectable		 5mugA-3d12B:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dip ENOLASE

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 389
VAL A 359
LEU A 382
VAL A 386
ILE A  10
 None
 1.02A 5mugA-3dipA:
3.1		 5mugA-3dipA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE

(Brucella
abortus) 		PF00171
(Aldedh) 		5 ILE A  21
ILE A 217
LEU A 221
VAL A 227
ILE A 179
 None
 0.88A 5mugA-3ek1A:
undetectable		 5mugA-3ek1A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1

(Candida
parapsilosis) 		PF00026
(Asp) 		5 VAL A  20
ILE A   8
ILE A  95
LEU A   5
ILE A  31
 None
 0.95A 5mugA-3fv3A:
undetectable		 5mugA-3fv3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxq LYSR TYPE REGULATOR
OF TSAMBCD

(Comamonas
testosteroni) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		5 ILE A 270
ILE A  94
LEU A 111
PHE A 118
VAL A 123
 None
 0.93A 5mugA-3fxqA:
undetectable		 5mugA-3fxqA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 LEU A 827
ILE A 783
VAL A 781
LEU A 760
VAL A 700
 None
 1.02A 5mugA-3h09A:
undetectable		 5mugA-3h09A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h14 AMINOTRANSFERASE,
CLASSES I AND II

(Ruegeria
pomeroyi) 		PF00155
(Aminotran_1_2) 		5 ILE A 202
ILE A 131
LEU A 132
VAL A 118
ILE A 120
 None
 1.02A 5mugA-3h14A:
undetectable		 5mugA-3h14A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		5 ILE M 215
ILE M 301
VAL M 173
LEU M 176
VAL M 302
 None
 1.02A 5mugA-3i04M:
undetectable		 5mugA-3i04M:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iby FERROUS IRON
TRANSPORT PROTEIN B

(Legionella
pneumophila) 		PF02421
(FeoB_N) 		5 VAL A 250
ILE A 168
ILE A  91
VAL A 143
VAL A 113
 None
 1.10A 5mugA-3ibyA:
undetectable		 5mugA-3ibyA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig4 XAA-PRO
AMINOPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 LEU A 229
ILE A 191
VAL A 194
LEU A 195
ILE A 408
 None
 0.69A 5mugA-3ig4A:
undetectable		 5mugA-3ig4A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8e D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE

(Escherichia
coli) 		PF13242
(Hydrolase_like) 		5 LEU A 173
ILE A  32
ILE A   8
VAL A 134
LEU A  10
 None
 1.09A 5mugA-3l8eA:
undetectable		 5mugA-3l8eA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me8 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aquifex
aeolicus) 		PF02630
(SCO1-SenC) 		5 ILE A  90
LEU A 133
ILE A 143
ILE A  47
PHE A  84
 None
 1.01A 5mugA-3me8A:
undetectable		 5mugA-3me8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7z ACETYLTRANSFERASE,
GNAT FAMILY

(Bacillus
anthracis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 ILE A 328
ILE A 372
ILE A 309
LEU A 341
ILE A 349
 None
 1.08A 5mugA-3n7zA:
undetectable		 5mugA-3n7zA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Salmonella
enterica) 		PF00290
(Trp_syntA) 		5 ILE A 237
ILE A  97
LEU A  50
VAL A  23
ILE A  37
 None
 1.04A 5mugA-3pr2A:
1.7		 5mugA-3pr2A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3q ALKALINE PHOSPHATASE

(Sphingomonas
sp. BSAR-1) 		PF01663
(Phosphodiest) 		5 ILE A 292
LEU A  67
ILE A 503
PHE A  56
ILE A  96
 None
 0.86A 5mugA-3q3qA:
undetectable		 5mugA-3q3qA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r67 PUTATIVE GLYCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		5 ILE A 280
VAL A 232
LEU A 238
VAL A 154
ILE A 214
 None
 1.02A 5mugA-3r67A:
undetectable		 5mugA-3r67A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		5 ILE A 122
ILE A 188
LEU A 185
VAL A 216
ILE A 199
 None
 1.09A 5mugA-3rjyA:
1.8		 5mugA-3rjyA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		5 ILE A 247
LEU A 271
VAL A 276
ILE A 279
PHE A 286
 None
 0.92A 5mugA-3t6qA:
undetectable		 5mugA-3t6qA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		5 ILE A 299
VAL A  94
ILE A  67
LEU A  63
VAL A 228
 None
 0.97A 5mugA-3tsyA:
undetectable		 5mugA-3tsyA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2p RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 VAL A 391
ILE A 447
ILE A 417
LEU A 441
ILE A 435
 None
 0.99A 5mugA-3u2pA:
undetectable		 5mugA-3u2pA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwd PHOSPHOGLYCERATE
KINASE

(Bacillus
anthracis) 		PF00162
(PGK) 		5 VAL A 117
LEU A  60
VAL A  76
LEU A  80
ILE A  44
 None
 1.06A 5mugA-3uwdA:
undetectable		 5mugA-3uwdA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhc PHYTASE

(Citrobacter
braakii) 		PF00328
(His_Phos_2) 		5 ILE A 299
VAL A  12
LEU A 297
VAL A 294
ILE A 290
 None
 0.95A 5mugA-3zhcA:
undetectable		 5mugA-3zhcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zto NUCLEOSIDE
DIPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00334
(NDK) 		5 ILE A  89
ILE A  34
LEU A  77
VAL A  86
ILE A   8
 None
 0.74A 5mugA-3ztoA:
undetectable		 5mugA-3ztoA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2

(Mus musculus) 		PF07528
(DZF) 		5 ILE A 128
VAL A 135
LEU A 138
VAL A  97
ILE A  99
 None
 0.75A 5mugA-4atbA:
undetectable		 5mugA-4atbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkf EPHRIN-B3

(Homo sapiens) 		PF00812
(Ephrin) 		5 VAL C 167
LEU C  50
ILE C 138
ILE C 115
LEU C 101
 None
 1.10A 5mugA-4bkfC:
undetectable		 5mugA-4bkfC:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmb GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 ILE A 105
ILE A  23
LEU A 138
PHE A  64
ILE A 149
 None
 1.07A 5mugA-4bmbA:
undetectable		 5mugA-4bmbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus) 		PF00793
(DAHP_synth_1) 		5 LEU A  46
ILE A 224
VAL A 228
LEU A 243
ILE A 210
 None
 0.96A 5mugA-4c1lA:
undetectable		 5mugA-4c1lA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dib GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A  12
VAL A 322
ILE A  71
VAL A  66
ILE A  44
 None
 0.93A 5mugA-4dibA:
undetectable		 5mugA-4dibA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grs PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE,
2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus;
Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 LEU A 117
ILE A 295
VAL A 299
LEU A 314
ILE A 281
 None
 0.95A 5mugA-4grsA:
undetectable		 5mugA-4grsA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxi KELCH-LIKE PROTEIN 3

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE A  93
VAL A  96
LEU A 101
ILE A 105
PHE A  79
 None
 0.98A 5mugA-4hxiA:
undetectable		 5mugA-4hxiA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis) 		PF00005
(ABC_tran) 		5 LEU A  49
ILE A  83
VAL A  64
LEU A  71
VAL A  79
 None
 1.04A 5mugA-4hzuA:
undetectable		 5mugA-4hzuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 ILE A 234
ILE A 214
LEU A 210
VAL A 237
ILE A 206
 None
 1.09A 5mugA-4jcmA:
2.2		 5mugA-4jcmA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng4 PHOSPHOGLYCERATE
KINASE

(Coxiella
burnetii) 		PF00162
(PGK) 		5 VAL A 115
LEU A  63
VAL A  80
LEU A  84
ILE A  47
 None
 0.99A 5mugA-4ng4A:
undetectable		 5mugA-4ng4A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0c NA(+)/H(+) EXCHANGE
REGULATORY COFACTOR
NHE-RF2/LYSOPHOSPHAT
IDIC ACID RECEPTOR 2
CHIMERIC PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  36
VAL A  87
LEU A  56
VAL A  59
ILE A  76
 None
 1.00A 5mugA-4p0cA:
undetectable		 5mugA-4p0cA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum pratense) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 VAL A 204
ILE A  79
LEU A 106
VAL A 104
ILE A  65
 None
None
FAD  A 601 (-4.8A)
None
None
 0.90A 5mugA-4pveA:
undetectable		 5mugA-4pveA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2n INAD-LIKE PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 VAL A 434
VAL A 445
LEU A 368
VAL A 366
ILE A 412
 None
 1.03A 5mugA-4q2nA:
undetectable		 5mugA-4q2nA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE

(Leishmania
major) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ILE A 407
VAL A 200
ILE A 307
ILE A 233
VAL A 296
 None
 0.63A 5mugA-4qg5A:
undetectable		 5mugA-4qg5A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 ILE A  41
ILE A 247
ILE A 241
LEU A 243
ILE A  26
 None
 1.01A 5mugA-4r6lA:
undetectable		 5mugA-4r6lA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8v CRISPR SYSTEM CMR
SUBUNIT CMR6

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		5 ILE A 226
LEU A 203
LEU A 320
VAL A 325
ILE A 149
 None
 1.03A 5mugA-4w8vA:
undetectable		 5mugA-4w8vA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvw GALECTIN

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		5 ILE A 104
ILE A  22
LEU A 137
PHE A  63
ILE A 148
 None
 1.06A 5mugA-4wvwA:
undetectable		 5mugA-4wvwA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x54 OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella ovis) 		PF13561
(adh_short_C2) 		5 VAL A 161
ILE A  75
LEU A  79
VAL A  77
ILE A  85
 None
 0.95A 5mugA-4x54A:
2.2		 5mugA-4x54A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x REELIN

(Mus musculus) 		PF07974
(EGF_2) 		5 LEU A2563
ILE A2661
VAL A2659
VAL A2624
ILE A2626
 None
 1.09A 5mugA-5b4xA:
undetectable		 5mugA-5b4xA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 ILE A 583
ILE A 711
ILE A 685
LEU A 669
ILE A 637
 None
 0.89A 5mugA-5bs5A:
undetectable		 5mugA-5bs5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt8 PHOSPHOGLYCERATE
KINASE

(Acinetobacter
baumannii) 		PF00162
(PGK) 		5 VAL A 112
LEU A  60
VAL A  77
LEU A  81
ILE A  44
 None
 1.05A 5mugA-5bt8A:
undetectable		 5mugA-5bt8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		5 LEU B 157
ILE B 192
VAL B 225
LEU B 228
VAL B 191
 None
 1.05A 5mugA-5do7B:
undetectable		 5mugA-5do7B:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elz TYPE II PANTOTHENATE
KINASE

(Staphylococcus
aureus) 		PF03630
(Fumble) 		5 ILE A  32
ILE A  63
LEU A  39
VAL A  35
ILE A   5
 None
 1.08A 5mugA-5elzA:
undetectable		 5mugA-5elzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsy MACRODOMAIN

(Trypanosoma
brucei) 		PF01661
(Macro) 		5 ILE A 192
VAL A 209
LEU A 218
VAL A 260
ILE A 102
 None
AR6  A1262 ( 4.5A)
None
None
None
 0.76A 5mugA-5fsyA:
undetectable		 5mugA-5fsyA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmk PRE-MRNA-SPLICING
FACTOR CWC22

(Saccharomyces
cerevisiae) 		PF02847
(MA3) 		5 VAL Z  61
ILE Z  21
LEU Z  44
VAL Z  47
ILE Z  49
 None
 1.07A 5mugA-5gmkZ:
undetectable		 5mugA-5gmkZ:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzg GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 ILE A 105
ILE A  23
LEU A 138
PHE A  64
ILE A 149
 None
 1.08A 5mugA-5gzgA:
undetectable		 5mugA-5gzgA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA

(Geobacillus
stearothermophilus) 		no annotation 5 ILE B 114
ILE B  71
LEU B  74
VAL B  76
ILE B 131
 None
 1.09A 5mugA-5ivlB:
undetectable		 5mugA-5ivlB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		5 VAL A 112
ILE A 552
ILE A 109
LEU A  97
VAL A 553
 None
 1.04A 5mugA-5mq6A:
undetectable		 5mugA-5mq6A:
17.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		12 ILE A 119
VAL A 132
LEU A 137
ILE A 154
TRP A 163
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
ILE A 194
PHE A 203
 None
VIV  A 302 (-4.4A)
VIV  A 302 ( 4.8A)
None
None
VIV  A 302 (-4.0A)
VIV  A 302 (-4.4A)
None
VIV  A 302 (-4.0A)
VIV  A 302 ( 4.9A)
VIV  A 302 ( 4.6A)
None
 0.31A 5mugA-5mueA:
39.4		 5mugA-5mueA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oom 39S RIBOSOMAL
PROTEIN L22,
MITOCHONDRIAL

(Homo sapiens) 		PF00237
(Ribosomal_L22) 		5 ILE T  73
ILE T 117
VAL T 120
LEU T 121
ILE T 142
 None
 1.03A 5mugA-5oomT:
undetectable		 5mugA-5oomT:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 5 ILE B 267
VAL B 328
VAL B 189
LEU B 190
ILE B 202
 None
 0.85A 5mugA-5txrB:
undetectable		 5mugA-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s DNA REPLICATION
LICENSING FACTOR
MCM4

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 LEU 4 544
ILE 4 671
ILE 4 577
VAL 4 581
LEU 4 578
 None
 0.96A 5mugA-5u8s4:
undetectable		 5mugA-5u8s4:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7f UGGT

(Thermomyces
dupontii) 		PF01501
(Glyco_transf_8) 		5 ILE A1350
LEU A1311
ILE A1399
LEU A1279
ILE A1276
 None
 1.04A 5mugA-5y7fA:
undetectable		 5mugA-5y7fA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		no annotation 5 ILE A 109
VAL A 208
ILE A  74
VAL A  76
PHE A  85
 None
 0.79A 5mugA-5yt0A:
undetectable		 5mugA-5yt0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zby HYDROGENASE
MATURATION PROTEASE
HYCI

(Thermococcus
kodakarensis) 		no annotation 5 ILE A  87
ILE A 154
LEU A 155
VAL A  46
ILE A  16
 None
 0.77A 5mugA-5zbyA:
undetectable		 5mugA-5zbyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 5 ILE A  14
VAL A  51
LEU A  54
VAL A  13
PHE A  70
 None
 0.92A 5mugA-6bfiA:
undetectable		 5mugA-6bfiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A 389
VAL A 374
LEU A 377
VAL A 419
ILE A 137
 None
 0.93A 5mugA-6c26A:
undetectable		 5mugA-6c26A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpe ATPASE YJEE,
PREDICTED TO HAVE
ESSENTIAL ROLE IN
CELL WALL
BIOSYNTHESIS

(Thermotoga
maritima) 		no annotation 5 ILE E 104
ILE E 126
LEU E  17
VAL E 136
ILE E 138
 None
 1.05A 5mugA-6fpeE:
undetectable		 5mugA-6fpeE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao5 GLANDULAR
KALLIKREIN-13

(Mus musculus) 		PF00089
(Trypsin) 		3 SER A 214
SER A 195
PHE A  94
 None
 0.91A 5mugA-1ao5A:
undetectable		 5mugA-1ao5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dju AROMATIC
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		3 SER A 332
SER A 336
PHE A 322
 None
 0.87A 5mugA-1djuA:
undetectable		 5mugA-1djuA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		3 SER A 368
SER A 394
PHE A 254
 PIN  A 506 ( 3.8A)
None
None
 0.88A 5mugA-1ecgA:
undetectable		 5mugA-1ecgA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ept PORCINE E-TRYPSIN
PORCINE E-TRYPSIN

(Sus scrofa;
Sus scrofa) 		PF00089
(Trypsin)
PF00089
(Trypsin) 		3 SER C 214
SER C 195
PHE B  94
 None
 0.92A 5mugA-1eptC:
undetectable		 5mugA-1eptC:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		3 SER B 646
SER B 583
PHE B 526
 None
 0.92A 5mugA-1gh6B:
undetectable		 5mugA-1gh6B:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		3 SER T 214
SER T 195
PHE T  94
 None
SO4  T 600 ( 2.6A)
None
 0.91A 5mugA-1j17T:
undetectable		 5mugA-1j17T:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		3 SER A 221
SER A 247
PHE A 101
 None
 0.89A 5mugA-1k4yA:
undetectable		 5mugA-1k4yA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 SER A 215
SER A 218
PHE A 435
 None
 0.92A 5mugA-1lamA:
undetectable		 5mugA-1lamA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mke FUSION PROTEIN
CONSISTING OF
WISKOTT-ALDRICH
SYNDROME PROTEIN
INTERACTING PROTEIN
(WIP), GSGSG LINKER,
AND NEURAL
WISKOTT-ALDRICH
SYNDROME PROTEIN
(N-WASP)

(Homo sapiens;
Rattus
norvegicus) 		PF00568
(WH1) 		3 SER A  17
SER A  24
PHE A  79
 None
 0.96A 5mugA-1mkeA:
undetectable		 5mugA-1mkeA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nln ADENAIN

(Human
mastadenovirus
C) 		PF00770
(Peptidase_C5) 		3 SER A  95
SER A  99
PHE A  29
 None
 0.80A 5mugA-1nlnA:
undetectable		 5mugA-1nlnA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		3 SER A 238
SER A 242
PHE A 371
 SO4  A 593 (-1.9A)
None
I40  A 997 (-4.9A)
 0.88A 5mugA-1qonA:
undetectable		 5mugA-1qonA:
17.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		3 SER A 136
SER A 140
PHE A 158
 VIV  A 301 (-3.5A)
VIV  A 301 (-3.1A)
VIV  A 301 (-3.9A)
 0.15A 5mugA-1r5lA:
37.0		 5mugA-1r5lA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgf NERVE GROWTH FACTOR

(Mus musculus) 		PF00089
(Trypsin) 		3 SER A 214
SER A 195
PHE A  94
 None
 0.91A 5mugA-1sgfA:
undetectable		 5mugA-1sgfA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgf NERVE GROWTH FACTOR

(Mus musculus) 		PF00089
(Trypsin) 		3 SER G 214
SER G 195
PHE G  94
 None
 0.71A 5mugA-1sgfG:
undetectable		 5mugA-1sgfG:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		3 SER A 460
SER A 457
PHE A 442
 None
 0.96A 5mugA-1ukcA:
undetectable		 5mugA-1ukcA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		3 SER A 438
SER A 436
PHE A 390
 None
 0.84A 5mugA-1ulvA:
undetectable		 5mugA-1ulvA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyh PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT

(Mus musculus) 		PF00400
(WD40) 		3 SER C 291
SER C 294
PHE C 346
 None
 0.75A 5mugA-1vyhC:
undetectable		 5mugA-1vyhC:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xuv HYPOTHETICAL PROTEIN
MM0500

(Methanosarcina
mazei) 		PF08327
(AHSA1) 		3 SER A 132
SER A 134
PHE A  41
 None
 0.70A 5mugA-1xuvA:
undetectable		 5mugA-1xuvA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlp PETAL DEATH PROTEIN

(Dianthus
caryophyllus) 		PF13714
(PEP_mutase) 		3 SER A 257
SER A  66
PHE A 207
 GAQ  A 402 ( 3.8A)
None
None
 0.97A 5mugA-1zlpA:
1.8		 5mugA-1zlpA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avt DNA POLYMERASE III
BETA SUBUNIT

(Streptococcus
pyogenes) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 SER A 321
SER A 319
PHE A 260
 None
 0.92A 5mugA-2avtA:
undetectable		 5mugA-2avtA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 SER A 766
SER A 768
PHE A 851
 None
 0.79A 5mugA-2b5mA:
undetectable		 5mugA-2b5mA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buf ACETYLGLUTAMATE
KINASE

(Pseudomonas
aeruginosa) 		PF00696
(AA_kinase) 		3 SER A 269
SER A 296
PHE A  25
 None
 0.93A 5mugA-2bufA:
undetectable		 5mugA-2bufA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ezv TYPE II RESTRICTION
ENZYME SFII

(Streptomyces
fimbriatus) 		PF11487
(RestrictionSfiI) 		3 SER A 243
SER A 240
PHE A 266
 None
 0.74A 5mugA-2ezvA:
undetectable		 5mugA-2ezvA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa1 PROBABLE
TRANSCRIPTIONAL
REGULATOR PHNF

(Escherichia
coli) 		PF07702
(UTRA) 		3 SER A 228
SER A 226
PHE A 237
 None
 0.71A 5mugA-2fa1A:
undetectable		 5mugA-2fa1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Saccharomyces
cerevisiae) 		PF03770
(IPK) 		3 SER A 257
SER A 329
PHE A 243
 None
 0.94A 5mugA-2iewA:
undetectable		 5mugA-2iewA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C

(Rattus
norvegicus;
Rattus
norvegicus) 		PF00089
(Trypsin)
PF00089
(Trypsin) 		3 SER C 214
SER C 195
PHE B  94
 None
 0.95A 5mugA-2jetC:
undetectable		 5mugA-2jetC:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
RIBONUCLEASE P
PROTEIN COMPONENT 4

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF01868
(UPF0086)
PF04032
(Rpr2) 		3 SER B  32
SER A  19
PHE A  30
 None
 0.90A 5mugA-2ki7B:
undetectable		 5mugA-2ki7B:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		3 SER A 678
SER A 659
PHE A 524
 None
 0.87A 5mugA-2odpA:
2.8		 5mugA-2odpA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opi L-FUCULOSE-1-PHOSPHA
TE ALDOLASE

(Bacteroides
thetaiotaomicron) 		PF00596
(Aldolase_II) 		3 SER A  72
SER A  41
PHE A  77
 SO4  A 301 (-2.6A)
None
None
 0.83A 5mugA-2opiA:
undetectable		 5mugA-2opiA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A 138
SER A 163
PHE A  53
 None
 0.90A 5mugA-2pceA:
1.8		 5mugA-2pceA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pka KALLIKREIN A
KALLIKREIN A

(Sus scrofa;
Sus scrofa) 		PF00089
(Trypsin)
PF00089
(Trypsin) 		3 SER B 214
SER B 195
PHE A  94
 None
BEN  B   1 ( 4.0A)
None
 0.83A 5mugA-2pkaB:
undetectable		 5mugA-2pkaB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv5 UNCHARACTERIZED
PROTEIN ATU2773

(Agrobacterium
fabrum) 		PF04748
(Polysacc_deac_2) 		3 SER A 312
SER A 309
PHE A 303
 None
 0.76A 5mugA-2qv5A:
1.7		 5mugA-2qv5A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6b BASEPLATE STRUCTURAL
PROTEIN GP27

(Escherichia
virus T4) 		PF09096
(Phage-tail_2)
PF09097
(Phage-tail_1) 		3 SER D 257
SER D 278
PHE D 376
 None
 0.77A 5mugA-2z6bD:
undetectable		 5mugA-2z6bD:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 3 SER A 730
SER A 676
PHE A 487
 None
 0.96A 5mugA-3a0fA:
undetectable		 5mugA-3a0fA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agb RED CHLOROPHYLL
CATABOLITE
REDUCTASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF06405
(RCC_reductase) 		3 SER A 121
SER A 137
PHE A 296
 None
 0.71A 5mugA-3agbA:
undetectable		 5mugA-3agbA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beu TRYPSIN

(Streptomyces
griseus) 		PF00089
(Trypsin) 		3 SER A 214
SER A 195
PHE A  94
 None
SO4  A 246 ( 2.5A)
None
 0.85A 5mugA-3beuA:
undetectable		 5mugA-3beuA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Bacteroides
fragilis) 		PF13407
(Peripla_BP_4) 		3 SER A 174
SER A 177
PHE A 169
 None
 0.96A 5mugA-3gbvA:
undetectable		 5mugA-3gbvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3he0 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Vibrio
parahaemolyticus) 		PF00440
(TetR_N)
PF16295
(TetR_C_10) 		3 SER A 156
SER A 186
PHE A 135
 None
 0.93A 5mugA-3he0A:
undetectable		 5mugA-3he0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		3 SER A 421
SER A 399
PHE A 461
 None
 0.87A 5mugA-3iu1A:
undetectable		 5mugA-3iu1A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		3 SER A 295
SER A 299
PHE A 333
 None
 0.75A 5mugA-3j4sA:
undetectable		 5mugA-3j4sA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 SER A 174
SER A 218
PHE A 193
 None
 0.68A 5mugA-3lk6A:
undetectable		 5mugA-3lk6A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myo TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 1

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		3 SER A  15
SER A  64
PHE A 160
 None
 0.89A 5mugA-3myoA:
undetectable		 5mugA-3myoA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		3 SER A 512
SER A 922
PHE A 909
 None
 0.93A 5mugA-3nafA:
undetectable		 5mugA-3nafA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus) 		PF08762
(CRPV_capsid) 		3 SER A 212
SER A 210
PHE A 261
 None
 0.67A 5mugA-3napA:
undetectable		 5mugA-3napA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nf4 ACYL-COA
DEHYDROGENASE

(Mycolicibacterium
thermoresistibile) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 SER A 317
SER A 321
PHE A 240
 None
 0.70A 5mugA-3nf4A:
undetectable		 5mugA-3nf4A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocd SOXA

(Starkeya
novella) 		no annotation 3 SER A  61
SER A  70
PHE A 142
 None
 0.93A 5mugA-3ocdA:
undetectable		 5mugA-3ocdA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdg FIBRONECTIN(III)-LIK
E MODULE

(Ruminiclostridium
thermocellum) 		no annotation 3 SER A   6
SER A  22
PHE A  13
 None
 0.97A 5mugA-3pdgA:
undetectable		 5mugA-3pdgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 SER A 203
SER A 207
PHE A 193
 ERC  A1201 (-2.8A)
ERC  A1201 (-2.7A)
ERC  A1201 (-4.4A)
 0.94A 5mugA-3pdsA:
undetectable		 5mugA-3pdsA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc2 GLYCOSYL HYDROLASE

(Bacteroides
ovatus) 		PF04041
(Glyco_hydro_130) 		3 SER A 203
SER A 205
PHE A 347
 None
 0.93A 5mugA-3qc2A:
undetectable		 5mugA-3qc2A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 3 SER N 302
SER N 219
PHE N 341
 None
 0.86A 5mugA-3rkoN:
undetectable		 5mugA-3rkoN:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8i PURINE NUCLEOSIDASE,
(IUNH-2)

(Sulfolobus
solfataricus) 		PF01156
(IU_nuc_hydro) 		3 SER A 239
SER A 243
PHE A 214
 None
 0.93A 5mugA-3t8iA:
undetectable		 5mugA-3t8iA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux9 INTERFERON
ALPHA-1/13

(Homo sapiens) 		PF00143
(Interferon) 		3 SER A 151
SER A 155
PHE A 124
 None
 0.90A 5mugA-3ux9A:
undetectable		 5mugA-3ux9A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w08 ALDOXIME DEHYDRATASE

(Pseudomonas
chlororaphis) 		PF13816
(Dehydratase_hem) 		3 SER A 325
SER A 323
PHE A 332
 None
 0.87A 5mugA-3w08A:
undetectable		 5mugA-3w08A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN

(Caenorhabditis
elegans) 		no annotation 3 SER A 291
SER A 294
PHE A 367
 None
 0.91A 5mugA-3zheA:
undetectable		 5mugA-3zheA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR

(Mus musculus) 		PF00079
(Serpin) 		3 SER A  59
SER A  63
PHE A 135
 None
 0.63A 5mugA-4ajtA:
undetectable		 5mugA-4ajtA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgv MALATE DEHYDROGENASE

(Picrophilus
torridus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 SER A  77
SER A 119
PHE A  33
 None
 0.70A 5mugA-4bgvA:
undetectable		 5mugA-4bgvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		3 SER A 421
SER A 399
PHE A 461
 None
 0.80A 5mugA-4c2xA:
undetectable		 5mugA-4c2xA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF05207
(zf-CSL) 		3 SER A 335
SER A   2
PHE A 323
 None
 0.86A 5mugA-4d4pA:
undetectable		 5mugA-4d4pA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e13 DIKETOREDUCTASE

(Acinetobacter
baylyi) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 SER A 248
SER A 251
PHE A 236
 1PE  A 306 (-3.1A)
1PE  A 306 ( 4.9A)
None
 0.90A 5mugA-4e13A:
undetectable		 5mugA-4e13A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		3 SER A  98
SER A 101
PHE A 132
 None
 0.96A 5mugA-4h1xA:
undetectable		 5mugA-4h1xA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifd EXOSOME COMPLEX
COMPONENT RRP43

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH) 		3 SER C 158
SER C 162
PHE C 227
 None
 0.87A 5mugA-4ifdC:
undetectable		 5mugA-4ifdC:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo sapiens) 		PF00089
(Trypsin) 		3 SER E 666
SER E 645
PHE E 526
 None
 0.82A 5mugA-4iw4E:
undetectable		 5mugA-4iw4E:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		3 SER A 229
SER A 224
PHE A 312
 None
 0.94A 5mugA-4j9uA:
undetectable		 5mugA-4j9uA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 128
SER A 115
PHE A 119
 None
 0.82A 5mugA-4jy4B:
undetectable		 5mugA-4jy4B:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n54 INOSITOL
DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 SER A 176
SER A  78
PHE A 167
 None
NAI  A 401 (-3.1A)
None
 0.85A 5mugA-4n54A:
undetectable		 5mugA-4n54A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onz PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
ovatus) 		PF04041
(Glyco_hydro_130) 		3 SER A 201
SER A 203
PHE A 345
 None
None
UNL  A 400 ( 3.9A)
 0.88A 5mugA-4onzA:
undetectable		 5mugA-4onzA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei) 		PF02608
(Bmp) 		3 SER A 120
SER A 118
PHE A  49
 BR  A 402 (-3.3A)
None
None
 0.72A 5mugA-4p98A:
undetectable		 5mugA-4p98A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7

(Colwellia
psychrerythraea) 		PF03480
(DctP) 		3 SER A 281
SER A 285
PHE A  49
 None
None
PYR  A 402 (-4.2A)
 0.78A 5mugA-4petA:
undetectable		 5mugA-4petA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 3 SER B 233
SER B 211
PHE B 131
 SF4  B 401 ( 4.8A)
None
SF4  B 401 ( 4.6A)
 0.92A 5mugA-4pl2B:
3.7		 5mugA-4pl2B:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		3 SER A 348
SER A 362
PHE A 245
 None
 0.93A 5mugA-4q6rA:
undetectable		 5mugA-4q6rA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		3 SER A  60
SER A  91
PHE A 366
 None
 0.62A 5mugA-4qmkA:
undetectable		 5mugA-4qmkA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 SER A 214
SER A 195
PHE A  94
 None
3KM  A 900 (-3.6A)
None
 0.92A 5mugA-4r0iA:
undetectable		 5mugA-4r0iA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryi INTEGRAL MEMBRANE
PROTEIN

(Bacillus cereus) 		PF03073
(TspO_MBR) 		3 SER A  22
SER A  91
PHE A  55
 PKA  A 201 (-2.9A)
PKA  A 201 (-2.9A)
PKA  A 201 (-4.9A)
 0.93A 5mugA-4ryiA:
undetectable		 5mugA-4ryiA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkr THIAMINE TRANSPORTER
THIA

(Listeria
monocytogenes) 		PF09515
(Thia_YuaJ) 		3 SER A  36
SER A  34
PHE A  87
 TPP  A 301 (-2.9A)
TPP  A 301 (-3.0A)
TPP  A 301 (-4.8A)
 0.50A 5mugA-4tkrA:
undetectable		 5mugA-4tkrA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4l BETA-LACTAMASE NDM-1

(Klebsiella
pneumoniae) 		PF00753
(Lactamase_B) 		3 SER A  75
SER A  63
PHE A 205
 ZN  A 302 ( 4.9A)
None
None
 0.88A 5mugA-4u4lA:
2.5		 5mugA-4u4lA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG

(Homo sapiens) 		PF04049
(ANAPC8)
PF13181
(TPR_8)
PF13414
(TPR_11) 		3 SER C  51
SER C  55
PHE C 170
 None
 0.93A 5mugA-4ui9C:
undetectable		 5mugA-4ui9C:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8i PROBABLE
SPHINGOSINE-1-PHOSPH
ATE LYASE

(Legionella
pneumophila) 		PF00282
(Pyridoxal_deC) 		3 SER A 355
SER A 369
PHE A 255
 None
 0.96A 5mugA-4w8iA:
undetectable		 5mugA-4w8iA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		3 SER B 200
SER B 202
PHE B 344
 MAN  B1386 ( 4.3A)
None
MAN  B1386 ( 4.1A)
 0.90A 5mugA-5a7vB:
undetectable		 5mugA-5a7vB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 SER A  56
SER A  59
PHE A  97
 None
 0.94A 5mugA-5ahkA:
undetectable		 5mugA-5ahkA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 SER A 470
SER A 372
PHE A 604
 None
 0.94A 5mugA-5ck0A:
undetectable		 5mugA-5ck0A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN

(Macaca mulatta;
Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 SER L  30
SER L  28
PHE H 100
 None
 0.83A 5mugA-5dd5L:
undetectable		 5mugA-5dd5L:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxe EUGENOL OXIDASE

(Rhodococcus
jostii) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 SER A 101
SER A  55
PHE A 521
 None
 0.94A 5mugA-5fxeA:
undetectable		 5mugA-5fxeA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggy IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		3 SER A 300
SER A 304
PHE A 143
 None
 0.84A 5mugA-5ggyA:
undetectable		 5mugA-5ggyA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		3 SER A 299
SER A 301
PHE A 268
 None
 0.89A 5mugA-5gmhA:
undetectable		 5mugA-5gmhA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnb SPIKE GLYCOPROTEIN

(Human
coronavirus
HKU1) 		PF09408
(Spike_rec_bind) 		3 SER A 381
SER A 606
PHE A 373
 None
 0.76A 5mugA-5gnbA:
undetectable		 5mugA-5gnbA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr6 RLMN METHYLASE

(Escherichia
coli) 		PF04055
(Radical_SAM) 		3 SER A 213
SER A 211
PHE A 131
 MET  A 501 ( 3.3A)
MET  A 501 (-2.5A)
5AD  A 503 (-4.6A)
 0.94A 5mugA-5hr6A:
3.8		 5mugA-5hr6A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		3 SER A1170
SER A1172
PHE A1133
 None
 0.93A 5mugA-5i6hA:
2.3		 5mugA-5i6hA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE

(Plasmodium
falciparum) 		PF07992
(Pyr_redox_2) 		3 SER A 241
SER A 239
PHE A 286
 None
 0.90A 5mugA-5jwbA:
undetectable		 5mugA-5jwbA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021

(Burkholderia
pseudomallei) 		PF00282
(Pyridoxal_deC) 		3 SER A 266
SER A 280
PHE A 162
 None
 0.84A 5mugA-5k1rA:
undetectable		 5mugA-5k1rA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		3 SER A 589
SER A 592
PHE A 712
 None
 0.93A 5mugA-5kd5A:
undetectable		 5mugA-5kd5A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l26 NUCLEOSIDE PERMEASE

(Neisseria
wadsworthii) 		PF01773
(Nucleos_tra2_N)
PF07662
(Nucleos_tra2_C)
PF07670
(Gate) 		3 SER A 187
SER A 109
PHE A 366
 URI  A 505 ( 4.3A)
None
URI  A 505 (-3.8A)
 0.88A 5mugA-5l26A:
undetectable		 5mugA-5l26A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlp UNCHARACTERIZED
PROTEIN

(Rickettsiella
grylli) 		no annotation 3 SER A  98
SER A 101
PHE A 239
 None
 0.95A 5mugA-5mlpA:
2.1		 5mugA-5mlpA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		3 SER A 136
SER A 140
PHE A 158
 VIV  A 302 (-3.5A)
VIV  A 302 (-3.2A)
VIV  A 302 (-3.9A)
 0.10A 5mugA-5mueA:
39.4		 5mugA-5mueA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oon UNDECAPRENYL-DIPHOSP
HATASE

(Escherichia
coli) 		no annotation 3 SER A 193
SER A 196
PHE A 254
 None
 0.91A 5mugA-5oonA:
undetectable		 5mugA-5oonA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svd NUCLEOLAR PROTEIN 9

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		3 SER A 295
SER A 301
PHE A 325
 SER  A 295 ( 0.0A)
SER  A 301 ( 0.0A)
PHE  A 325 ( 1.3A)
 0.90A 5mugA-5svdA:
undetectable		 5mugA-5svdA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		3 SER A 545
SER A1161
PHE A 496
 EDO  A1804 (-3.8A)
None
None
 0.95A 5mugA-5x7sA:
undetectable		 5mugA-5x7sA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 3 SER A 280
SER A 283
PHE A 490
 None
 0.85A 5mugA-6arxA:
undetectable		 5mugA-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2

(Eptatretus
burgeri;
Danio rerio;
Petromyzon
marinus) 		no annotation
no annotation 		3 SER C  36
SER C  57
PHE A  75
 None
 0.83A 5mugA-6bxaC:
undetectable		 5mugA-6bxaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC

(Acetobacterium
woodii) 		no annotation 3 SER C  83
SER C  87
PHE C 358
 None
SO4  C 406 (-2.9A)
None
 0.88A 5mugA-6fahC:
undetectable		 5mugA-6fahC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 3 SER B 340
SER B 344
PHE B 385
 None
CLA  B1222 (-3.3A)
BCR  B4008 (-4.8A)
 0.93A 5mugA-6fosB:
undetectable		 5mugA-6fosB:
undetectable