SIMILAR PATTERNS OF AMINO ACIDS FOR 5MUE_A_VIVA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		5 ILE L  14
VAL L 471
LEU L 468
VAL L  30
ILE L  28
 None
 0.83A 5mueA-1cc1L:
undetectable		 5mueA-1cc1L:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		6 VAL A 302
ILE A 257
VAL A 260
LEU A 261
VAL A 175
ILE A 333
 None
 1.27A 5mueA-1cliA:
0.0		 5mueA-1cliA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		6 ILE A 375
VAL A 440
ILE A 424
LEU A 488
VAL A 464
ILE A 385
 None
 1.45A 5mueA-1d4eA:
0.2		 5mueA-1d4eA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 VAL A  42
ILE A  99
LEU A  60
VAL A  91
ILE A  88
 None
 0.91A 5mueA-1ex9A:
2.7		 5mueA-1ex9A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		5 VAL A 394
VAL A 141
LEU A 140
VAL A 401
PHE A 275
 None
 0.98A 5mueA-1f26A:
0.0		 5mueA-1f26A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f75 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Micrococcus
luteus) 		PF01255
(Prenyltransf) 		5 ILE A 220
ILE A  20
ILE A  56
VAL A  65
ILE A  24
 None
 0.83A 5mueA-1f75A:
2.6		 5mueA-1f75A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis aries) 		PF00089
(Trypsin) 		6 ILE A 108
VAL A  31
ILE A 103
VAL A 209
LEU A 123
ILE A 238
 None
 1.19A 5mueA-1fiwA:
undetectable		 5mueA-1fiwA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 ILE A 108
VAL A  31
ILE A 103
VAL A 209
LEU A 123
 None
 0.87A 5mueA-1fizA:
undetectable		 5mueA-1fizA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvf SEC1

(Doryteuthis
pealeii) 		PF00995
(Sec1) 		5 ILE A 588
ILE A 430
ILE A 448
LEU A 421
VAL A 425
 None
 0.98A 5mueA-1fvfA:
0.0		 5mueA-1fvfA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  39
VAL A  90
LEU A  59
VAL A  62
ILE A  79
 None
 0.98A 5mueA-1gq4A:
undetectable		 5mueA-1gq4A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqe HISTAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF13489
(Methyltransf_23) 		5 ILE A 139
ILE A 151
LEU A 155
PHE A 157
ILE A 170
 None
 0.71A 5mueA-1jqeA:
undetectable		 5mueA-1jqeA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no5 HYPOTHETICAL PROTEIN
HI0073

(Haemophilus
influenzae) 		PF01909
(NTP_transf_2) 		6 ILE A  94
VAL A  37
ILE A 101
VAL A  17
LEU A  21
ILE A  51
 None
 1.41A 5mueA-1no5A:
undetectable		 5mueA-1no5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pe9 PECTATE LYASE A

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		5 ILE A  65
PHE A  44
ILE A 118
VAL A 116
ILE A  57
 None
 0.95A 5mueA-1pe9A:
undetectable		 5mueA-1pe9A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		5 ILE A 199
ILE A  57
LEU A  17
VAL A  88
ILE A 225
 None
 0.96A 5mueA-1pk9A:
undetectable		 5mueA-1pk9A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		5 VAL A 401
ILE A 371
ILE A 427
LEU A 426
ILE A 352
 None
 0.62A 5mueA-1q5aA:
undetectable		 5mueA-1q5aA:
14.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		12 ILE A 119
VAL A 132
ILE A 154
PHE A 158
TRP A 163
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
ILE A 194
PHE A 203
 None
VIV  A 301 ( 4.7A)
None
VIV  A 301 (-3.9A)
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
VIV  A 301 ( 4.5A)
None
 0.20A 5mueA-1r5lA:
39.2		 5mueA-1r5lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		6 VAL A 135
PHE A 158
VAL A 182
LEU A 183
VAL A 191
ILE A 194
 None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-4.7A)
VIV  A 301 ( 4.5A)
 1.21A 5mueA-1r5lA:
39.2		 5mueA-1r5lA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli) 		PF00294
(PfkB) 		5 ILE A 184
ILE A 197
VAL A 211
VAL A 220
ILE A 222
 None
 0.88A 5mueA-1rk2A:
undetectable		 5mueA-1rk2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR

(Bacillus
megaterium) 		no annotation 5 ILE G  73
ILE G 121
LEU G  95
VAL G  65
ILE G  67
 None
 0.97A 5mueA-1rzrG:
undetectable		 5mueA-1rzrG:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tq4 INTERFERON-INDUCIBLE
GTPASE

(Mus musculus) 		PF05049
(IIGP) 		5 ILE A 165
PHE A 160
LEU A 229
PHE A 240
VAL A 185
 None
 0.95A 5mueA-1tq4A:
undetectable		 5mueA-1tq4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE

(Pinus
sylvestris) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ILE A 192
LEU A 130
PHE A 145
VAL A 157
ILE A 127
 None
 0.89A 5mueA-1u0uA:
undetectable		 5mueA-1u0uA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		5 ILE C 701
ILE C 690
VAL C 693
LEU C 694
ILE C 730
 None
 0.87A 5mueA-1u6gC:
undetectable		 5mueA-1u6gC:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vk9 CONSERVED
HYPOTHETICAL PROTEIN
TM1506

(Thermotoga
maritima) 		PF08973
(TM1506) 		5 ILE A 101
ILE A 128
VAL A  39
LEU A  36
VAL A 132
 None
 0.97A 5mueA-1vk9A:
undetectable		 5mueA-1vk9A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3e 50S RIBOSOMAL
PROTEIN L30E

(Thermococcus
celer) 		PF01248
(Ribosomal_L7Ae) 		5 ILE X  16
PHE X   3
LEU X  34
VAL X  85
ILE X  93
 None
 0.97A 5mueA-1w3eX:
undetectable		 5mueA-1w3eX:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9r UMECYANIN

(Armoracia
rusticana) 		PF02298
(Cu_bind_like) 		5 ILE A  84
ILE A  73
LEU A  75
VAL A 101
ILE A  99
 None
 0.92A 5mueA-1x9rA:
undetectable		 5mueA-1x9rA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yht DSPB

(Aggregatibacter
actinomycetemcomitans) 		PF00728
(Glyco_hydro_20) 		5 VAL A  34
ILE A 329
LEU A 327
VAL A 353
PHE A 287
 None
 0.96A 5mueA-1yhtA:
1.5		 5mueA-1yhtA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytf PROTEIN
(TRANSCRIPTION
FACTOR IIA - TOA1C
SUBUNIT)
PROTEIN
(TRANSCRIPTION
FACTOR IIA - TOA2
SUBUNIT)

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF03153
(TFIIA)
PF02268
(TFIIA_gamma_N)
PF02751
(TFIIA_gamma_C) 		5 ILE D 113
VAL D  80
LEU D 111
VAL D 108
ILE C 269
 None
 0.91A 5mueA-1ytfD:
undetectable		 5mueA-1ytfD:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1

(Medicago
truncatula) 		PF00201
(UDPGT) 		5 ILE A  15
ILE A  59
VAL A  62
LEU A  63
ILE A  69
 None
 0.84A 5mueA-2acvA:
undetectable		 5mueA-2acvA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be7 ASPARTATE
CARBAMOYLTRANSFERASE
CATALYTIC CHAIN

(Moritella
profunda) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ILE A 125
VAL A 303
LEU A 300
ILE A  64
PHE A  49
 None
 0.99A 5mueA-2be7A:
2.2		 5mueA-2be7A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew9 COPPER-TRANSPORTING
ATPASE 2

(Homo sapiens) 		PF00403
(HMA) 		5 ILE A  53
ILE A  22
LEU A  26
VAL A  32
ILE A  46
 None
 0.99A 5mueA-2ew9A:
undetectable		 5mueA-2ew9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fph YLMH

(Streptococcus
pneumoniae) 		no annotation 5 ILE X 155
ILE X 108
LEU X 149
VAL X 157
ILE X  94
 None
 0.91A 5mueA-2fphX:
undetectable		 5mueA-2fphX:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gup ROK FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF00480
(ROK) 		5 ILE A   8
PHE A  82
LEU A  97
VAL A  59
ILE A  70
 None
 0.99A 5mueA-2gupA:
undetectable		 5mueA-2gupA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi6 UPF0107 PROTEIN
AF0055

(Archaeoglobus
fulgidus) 		PF01989
(DUF126) 		5 VAL A  48
PHE A  26
ILE A  99
LEU A 101
ILE A  90
 None
 0.92A 5mueA-2hi6A:
1.7		 5mueA-2hi6A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxd DCTP DEAMINASE,
DUMP-FORMING

(Methanocaldococcus
jannaschii) 		PF00692
(dUTPase) 		5 ILE A 142
VAL A  34
ILE A  65
LEU A 125
VAL A  67
 DUP  A 206 (-4.3A)
None
None
None
None
 0.99A 5mueA-2hxdA:
undetectable		 5mueA-2hxdA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l2b STICHOLYSIN-2

(Stichodactyla
helianthus) 		PF06369
(Anemone_cytotox) 		5 ILE A   7
VAL A  20
PHE A 102
VAL A 100
ILE A  35
 None
 0.98A 5mueA-2l2bA:
undetectable		 5mueA-2l2bA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN

(Bacillus
megaterium) 		PF13377
(Peripla_BP_3) 		5 ILE G  73
ILE G 121
LEU G  95
VAL G  65
ILE G  67
 BG6  G1092 (-4.4A)
None
None
None
None
 0.96A 5mueA-2nzuG:
1.5		 5mueA-2nzuG:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW

(Escherichia
virus T4) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		6 ILE A 482
ILE A 430
VAL A 432
LEU A 433
VAL A 451
ILE A 299
 None
 1.26A 5mueA-2ocaA:
undetectable		 5mueA-2ocaA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prz OROTATE
PHOSPHORIBOSYLTRANSF
ERASE 1

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		5 ILE A  78
VAL A 118
ILE A 146
VAL A 154
ILE A 129
 None
 0.94A 5mueA-2przA:
undetectable		 5mueA-2przA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4

(Azotobacter
vinelandii) 		PF12708
(Pectate_lyase_3) 		5 ILE A 267
VAL A 277
LEU A 254
VAL A 252
ILE A 239
 None
 0.98A 5mueA-2pyhA:
undetectable		 5mueA-2pyhA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjl UBIQUITIN-RELATED
MODIFIER 1

(Saccharomyces
cerevisiae) 		PF09138
(Urm1) 		6 ILE A  15
PHE A   8
ILE A  38
VAL A  34
LEU A  37
VAL A   4
 None
None
EDO  A2001 (-4.3A)
None
None
None
 1.40A 5mueA-2qjlA:
undetectable		 5mueA-2qjlA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		5 ILE A 328
VAL A 332
LEU A 299
ILE A 304
PHE A 372
 None
 0.89A 5mueA-2r6fA:
undetectable		 5mueA-2r6fA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN

(Bacillus
thuringiensis) 		PF01338
(Bac_thur_toxin) 		6 ILE A 205
VAL A 195
ILE A 189
PHE A 143
ILE A 101
ILE A 139
 ILE  A 205 ( 0.7A)
VAL  A 195 ( 0.5A)
ILE  A 189 ( 0.7A)
PHE  A 143 ( 1.3A)
ILE  A 101 ( 0.7A)
ILE  A 139 ( 0.7A)
 1.49A 5mueA-2rciA:
undetectable		 5mueA-2rciA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN

(Bacillus
thuringiensis) 		PF01338
(Bac_thur_toxin) 		6 ILE A 205
VAL A 195
ILE A 189
PHE A 143
VAL A 100
ILE A 139
 ILE  A 205 ( 0.7A)
VAL  A 195 ( 0.5A)
ILE  A 189 ( 0.7A)
PHE  A 143 ( 1.3A)
VAL  A 100 ( 0.6A)
ILE  A 139 ( 0.7A)
 1.47A 5mueA-2rciA:
undetectable		 5mueA-2rciA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 292
LEU A 322
VAL A 297
ILE A 390
PHE A 394
 None
 0.94A 5mueA-2rjtA:
undetectable		 5mueA-2rjtA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		6 ILE A 319
PHE A 243
ILE A 253
VAL A 226
VAL A 215
ILE A 284
 None
 1.45A 5mueA-2rmpA:
undetectable		 5mueA-2rmpA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0s LR1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 ILE A  15
ILE A 111
ILE A  62
VAL A 100
ILE A  98
 None
 0.97A 5mueA-2v0sA:
undetectable		 5mueA-2v0sA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-RELATED
GTP-BINDING PROTEIN
RHOE

(Homo sapiens) 		PF00071
(Ras) 		5 VAL B 198
ILE B  26
LEU B  99
VAL B 133
ILE B 189
 None
 0.90A 5mueA-2v55B:
undetectable		 5mueA-2v55B:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vo1 CTP SYNTHASE 1

(Homo sapiens) 		PF06418
(CTP_synth_N) 		6 VAL A 236
ILE A   4
ILE A 242
LEU A 257
VAL A  23
ILE A  19
 None
 1.43A 5mueA-2vo1A:
undetectable		 5mueA-2vo1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqd BIOTIN CARBOXYLASE

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A  95
ILE A   7
VAL A   5
LEU A   6
ILE A  66
 None
 0.96A 5mueA-2vqdA:
undetectable		 5mueA-2vqdA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		6 VAL A1648
ILE A1769
ILE A1687
LEU A1659
ILE A1673
PHE A1712
 None
NAP  A3001 (-4.1A)
None
None
None
None
 1.36A 5mueA-2vz9A:
undetectable		 5mueA-2vz9A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5q SSO1986

(Sulfolobus
solfataricus) 		no annotation 5 VAL A  11
ILE A 161
LEU A 158
VAL A 181
ILE A 153
 None
 0.92A 5mueA-2x5qA:
undetectable		 5mueA-2x5qA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfm PIWI-LIKE PROTEIN 1

(Mus musculus) 		PF02170
(PAZ) 		5 ILE A 308
ILE A 323
LEU A 363
VAL A 309
PHE A 296
 A  B   5 ( 2.9A)
None
None
None
None
 0.96A 5mueA-2xfmA:
undetectable		 5mueA-2xfmA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 VAL A 883
LEU A 891
PHE A 967
ILE A 905
PHE A 943
 None
 0.94A 5mueA-2xvgA:
1.5		 5mueA-2xvgA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
SUBUNIT 5A

(Bos taurus) 		PF02284
(COX5A) 		5 ILE E  24
PHE E  19
ILE E  67
VAL E  70
ILE E  47
 None
 0.79A 5mueA-2y69E:
undetectable		 5mueA-2y69E:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzt PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF16916
(ZT_dimer) 		5 ILE A 220
VAL A 223
LEU A 224
VAL A 230
ILE A 251
 None
 0.98A 5mueA-2zztA:
undetectable		 5mueA-2zztA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbx DISHEVELLED-2

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A 294
ILE A 347
VAL A 320
LEU A 349
ILE A 280
 None
 0.98A 5mueA-3cbxA:
undetectable		 5mueA-3cbxA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d79 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0734

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF09183
(DUF1947) 		5 VAL A  54
ILE A 166
ILE A  67
ILE A 137
PHE A  25
 None
 0.99A 5mueA-3d79A:
undetectable		 5mueA-3d79A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum) 		PF00067
(p450) 		5 ILE A  11
PHE A 355
LEU A  71
VAL A  51
ILE A 357
 None
 0.99A 5mueA-3danA:
undetectable		 5mueA-3danA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 VAL A 340
ILE A 348
LEU A 220
VAL A 196
ILE A 186
 None
 0.92A 5mueA-3db2A:
undetectable		 5mueA-3db2A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF04045
(P34-Arc)
PF05856
(ARPC4) 		5 VAL F 142
PHE F 116
VAL D 294
LEU D 295
ILE F 103
 None
 0.93A 5mueA-3dwlF:
undetectable		 5mueA-3dwlF:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE

(Brucella
abortus) 		PF00171
(Aldedh) 		5 ILE A  21
ILE A 217
LEU A 221
VAL A 227
ILE A 179
 None
 0.84A 5mueA-3ek1A:
undetectable		 5mueA-3ek1A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjy PROBABLE MUTT1
PROTEIN

(Bifidobacterium
adolescentis) 		PF00293
(NUDIX)
PF00300
(His_Phos_1) 		5 VAL A 304
ILE A 351
ILE A 298
LEU A 191
ILE A 286
 None
 0.99A 5mueA-3fjyA:
undetectable		 5mueA-3fjyA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnk CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		5 ILE A  27
ILE A  95
PHE A 125
VAL A  44
LEU A  98
 None
 0.93A 5mueA-3fnkA:
undetectable		 5mueA-3fnkA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxq LYSR TYPE REGULATOR
OF TSAMBCD

(Comamonas
testosteroni) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		5 ILE A 270
ILE A  94
LEU A 111
PHE A 118
VAL A 123
 None
 0.93A 5mueA-3fxqA:
undetectable		 5mueA-3fxqA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghp CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		5 ILE A  27
ILE A  95
PHE A 125
VAL A  44
LEU A  98
 None
 0.96A 5mueA-3ghpA:
undetectable		 5mueA-3ghpA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		6 VAL A  33
PHE A  74
ILE A  80
LEU A  97
PHE A  86
VAL A  99
 None
 1.44A 5mueA-3i2tA:
undetectable		 5mueA-3i2tA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		6 ILE A 356
ILE A 368
VAL A 359
LEU A 518
PHE A 360
VAL A 345
 None
 1.38A 5mueA-3iayA:
undetectable		 5mueA-3iayA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		5 ILE A 190
ILE A 258
PHE A 288
VAL A 207
LEU A 261
 None
 0.96A 5mueA-3l8qA:
undetectable		 5mueA-3l8qA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5u PHOSPHOSERINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00266
(Aminotran_5) 		5 ILE A  35
PHE A 238
ILE A  17
LEU A  13
ILE A 195
 None
 0.96A 5mueA-3m5uA:
undetectable		 5mueA-3m5uA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9u CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 7

(Homo sapiens) 		PF00076
(RRM_1) 		5 VAL C 138
LEU C 141
VAL C 107
ILE C 102
PHE C  89
 None
 0.92A 5mueA-3n9uC:
undetectable		 5mueA-3n9uC:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of3 PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE 1

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 ILE A 213
ILE A  71
LEU A  31
VAL A 102
ILE A 239
 None
 0.98A 5mueA-3of3A:
undetectable		 5mueA-3of3A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 ILE B 206
VAL B 301
ILE B 142
ILE B 319
VAL B 165
 None
 0.99A 5mueA-3or2B:
undetectable		 5mueA-3or2B:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 ILE B 134
PHE B 122
ILE B 147
LEU B 153
ILE B 127
 None
 0.96A 5mueA-3pcoB:
undetectable		 5mueA-3pcoB:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		5 ILE A 288
PHE A   6
LEU A 253
PHE A 221
ILE A  10
 None
 0.89A 5mueA-3pieA:
undetectable		 5mueA-3pieA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3q ALKALINE PHOSPHATASE

(Sphingomonas
sp. BSAR-1) 		PF01663
(Phosphodiest) 		5 ILE A  35
ILE A  96
PHE A 505
ILE A 503
PHE A 513
 None
 0.87A 5mueA-3q3qA:
undetectable		 5mueA-3q3qA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtg PYRUVATE KINASE

(Pyrobaculum
aerophilum) 		PF00224
(PK)
PF02887
(PK_C) 		5 VAL A 227
ILE A  61
LEU A  49
VAL A  57
ILE A 190
 None
 0.93A 5mueA-3qtgA:
2.2		 5mueA-3qtgA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r07 PUTATIVE
LIPOATE-PROTEIN
LIGASE A SUBUNIT 2

(Thermoplasma
acidophilum) 		PF10437
(Lip_prot_lig_C) 		5 VAL C  71
ILE C  63
LEU C  85
VAL C  18
ILE C  30
 None
 0.99A 5mueA-3r07C:
undetectable		 5mueA-3r07C:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 ILE A 888
ILE A 851
ILE A 919
LEU A 916
VAL A 848
 None
 0.92A 5mueA-3s5kA:
undetectable		 5mueA-3s5kA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2

(Rattus
norvegicus) 		PF01070
(FMN_dh) 		5 ILE A 104
ILE A 298
VAL A 319
LEU A 320
ILE A 100
 None
 0.96A 5mueA-3sgzA:
undetectable		 5mueA-3sgzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		5 ILE A 247
LEU A 271
VAL A 276
ILE A 279
PHE A 286
 None
 0.96A 5mueA-3t6qA:
undetectable		 5mueA-3t6qA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		5 ILE A 299
VAL A  94
ILE A  67
LEU A  63
VAL A 228
 None
 0.99A 5mueA-3tsyA:
undetectable		 5mueA-3tsyA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2p RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 VAL A 391
ILE A 447
ILE A 417
LEU A 441
ILE A 435
 None
 0.94A 5mueA-3u2pA:
undetectable		 5mueA-3u2pA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uh8 ORF48

(Lactococcus
phage TP901-1) 		PF10651
(DUF2479) 		5 PHE A  52
VAL A 121
LEU A  22
VAL A  20
ILE A  32
 None
 0.95A 5mueA-3uh8A:
undetectable		 5mueA-3uh8A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyl L-RIBULOSE
3-EPIMERASE

(Mesorhizobium
loti) 		PF01261
(AP_endonuc_2) 		5 ILE A  35
ILE A  47
LEU A  98
VAL A  61
ILE A  63
 None
 0.86A 5mueA-3vylA:
1.6		 5mueA-3vylA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162

(Thermotoga
maritima) 		PF12706
(Lactamase_B_2) 		5 ILE A 136
PHE A  98
ILE A  69
LEU A  45
ILE A  19
 None
 0.99A 5mueA-3x2zA:
undetectable		 5mueA-3x2zA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zto NUCLEOSIDE
DIPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00334
(NDK) 		5 ILE A  89
ILE A  34
LEU A  77
VAL A  86
ILE A   8
 None
 0.78A 5mueA-3ztoA:
undetectable		 5mueA-3ztoA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3x EPA1P

([Candida]
glabrata) 		PF10528
(GLEYA) 		5 PHE A 248
ILE A 219
VAL A 169
LEU A 221
ILE A 109
 None
 0.80A 5mueA-4a3xA:
undetectable		 5mueA-4a3xA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4k ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF13234
(rRNA_proc-arch) 		5 ILE A1035
ILE A 983
LEU A 899
VAL A 922
ILE A 895
 None
 0.95A 5mueA-4a4kA:
undetectable		 5mueA-4a4kA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asl EPA1P

([Candida]
glabrata) 		PF10528
(GLEYA) 		5 PHE A 248
ILE A 219
VAL A 169
LEU A 221
ILE A 109
 None
 0.82A 5mueA-4aslA:
undetectable		 5mueA-4aslA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2

(Mus musculus) 		PF07528
(DZF) 		6 ILE A 128
ILE A 175
VAL A 135
LEU A 138
VAL A  97
ILE A  99
 None
 1.03A 5mueA-4atbA:
undetectable		 5mueA-4atbA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA

(Drosophila
melanogaster;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		6 ILE R 257
VAL R 264
ILE R 216
ILE R 250
VAL R 247
LEU R 226
 None
 1.42A 5mueA-4bv4R:
undetectable		 5mueA-4bv4R:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Bacillus
subtilis) 		PF01048
(PNP_UDP_1) 		5 ILE A 198
ILE A  57
LEU A  17
VAL A  88
ILE A 224
 None
 0.95A 5mueA-4daoA:
undetectable		 5mueA-4daoA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfs GLYCOSIDE HYDROLASE,
FAMILY 16

(Thermotoga
petrophila) 		PF00722
(Glyco_hydro_16) 		6 ILE A  32
ILE A  27
PHE A  30
ILE A  65
LEU A  63
ILE A  23
 None
 1.29A 5mueA-4dfsA:
undetectable		 5mueA-4dfsA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgf SULFATE TRANSPORTER
SULFATE TRANSPORTER
FAMILY PROTEIN

(Wolinella
succinogenes) 		PF01740
(STAS) 		5 ILE A 459
VAL A 522
LEU A 526
VAL A 492
ILE A 495
 FMT  A 602 (-4.7A)
None
None
None
None
 0.99A 5mueA-4dgfA:
3.3		 5mueA-4dgfA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans;
Homo sapiens) 		PF10275
(Peptidase_C65) 		6 ILE A 176
ILE A  82
ILE A 169
LEU A 160
VAL A  44
PHE A 111
 None
 1.42A 5mueA-4dhzA:
undetectable		 5mueA-4dhzA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dib GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A  12
VAL A 322
ILE A  71
VAL A  66
ILE A  44
 None
 0.91A 5mueA-4dibA:
undetectable		 5mueA-4dibA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		5 ILE A 144
ILE A  91
VAL A  94
LEU A  95
VAL A  99
 None
 0.83A 5mueA-4e4yA:
undetectable		 5mueA-4e4yA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 ILE A 758
ILE A 747
VAL A 750
LEU A 751
VAL A 755
 None
 0.97A 5mueA-4fddA:
undetectable		 5mueA-4fddA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gps KLLA0E02245P

(Kluyveromyces
lactis) 		no annotation 5 ILE A 192
VAL A 382
PHE A 158
ILE A 360
ILE A 253
 None
 0.99A 5mueA-4gpsA:
undetectable		 5mueA-4gpsA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE

(Homo sapiens) 		PF00291
(PALP) 		5 ILE A 282
ILE A 148
VAL A 177
LEU A 180
VAL A 149
 None
 0.79A 5mueA-4h27A:
undetectable		 5mueA-4h27A:
21.29