SIMILAR PATTERNS OF AMINO ACIDS FOR 5MTH_A_ACTA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ad0 ANTIBODY A5B7 (HEAVY
CHAIN)


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER B 112
ALA B 114
PHE B 146
LEU B 170
None
0.32A 5mthA-1ad0B:
27.3
5mthA-1ad0B:
57.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cr9 FAB ANTIBODY HEAVY
CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 109
ALA H 111
PHE H 143
LEU H 167
None
0.34A 5mthA-1cr9H:
27.7
5mthA-1cr9H:
71.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ct8 7C8 FAB FRAGMENT
LONG CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER B 112
ALA B 114
PHE B 146
LEU B 170
ASP B 173
None
1.01A 5mthA-1ct8B:
30.0
5mthA-1ct8B:
77.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1emt IGG ANTIBODY (HEAVY
CHAIN)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 115
ALA H 117
PHE H 149
LEU H 173
ASP H 176
None
0.55A 5mthA-1emtH:
28.7
5mthA-1emtH:
82.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 112
ALA H 114
PHE H 148
LEU H 178
ASP H 181
None
0.44A 5mthA-1fptH:
28.6
5mthA-1fptH:
79.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 117
ALA H 119
PHE H 151
LEU H 175
None
0.41A 5mthA-1i9iH:
27.9
5mthA-1i9iH:
72.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1igy IGG1 INTACT ANTIBODY
MAB61.1.3


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER B 112
ALA B 114
PHE B 148
LEU B 178
ASP B 183
None
1.03A 5mthA-1igyB:
18.8
5mthA-1igyB:
80.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ikf IGG1-KAPPA R45-45-11
FAB (HEAVY CHAIN)


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 125
ALA H 127
PHE H 159
LEU H 183
ASP H 186
None
0.45A 5mthA-1ikfH:
26.8
5mthA-1ikfH:
68.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1il1 MONOCLONAL ANTIBODY
G3-519 (HEAVY CHAIN)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER A 120
ALA A 122
PHE A 154
LEU A 178
ASP A 181
None
0.42A 5mthA-1il1A:
19.4
5mthA-1il1A:
79.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lk3 9D7 HEAVY CHAIN

(Rattus
norvegicus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 118
ALA H 120
PHE H 152
LEU H 176
None
0.38A 5mthA-1lk3H:
19.8
5mthA-1lk3H:
76.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mam IGG2B-KAPPA YST9.1
FAB (HEAVY CHAIN)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 118
ALA H 120
PHE H 152
LEU H 176
None
0.40A 5mthA-1mamH:
24.5
5mthA-1mamH:
63.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mj8 IMMUNOGLOBULIN
MS6-126


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 112
ALA H 114
PHE H 148
LEU H 178
ASP H 183
None
0.49A 5mthA-1mj8H:
28.2
5mthA-1mj8H:
76.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nld FAB1583

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 112
ALA H 114
PHE H 146
LEU H 170
ASP H 173
None
0.79A 5mthA-1nldH:
26.3
5mthA-1nldH:
64.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pz5 HEAVY CHAIN OF FAB
(SYA/J6)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER B 112
ALA B 114
PHE B 146
LEU B 170
None
0.36A 5mthA-1pz5B:
26.7
5mthA-1pz5B:
56.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q0y FAB 9B1, HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 112
ALA H 114
PHE H 148
LEU H 178
ASP H 183
None
0.82A 5mthA-1q0yH:
23.7
5mthA-1q0yH:
75.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rfd FAB M82G2, HEAVY
CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 112
ALA H 114
PHE H 148
LEU H 178
ASP H 181
None
0.60A 5mthA-1rfdH:
26.9
5mthA-1rfdH:
65.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rur IMMUNOGLOBULIN 13G5,
HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 112
ALA H 114
PHE H 148
LEU H 178
None
0.36A 5mthA-1rurH:
19.4
5mthA-1rurH:
84.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rz8 FAB 17B HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER B 112
ALA B 114
PHE B 146
LEU B 170
None
0.35A 5mthA-1rz8B:
17.3
5mthA-1rz8B:
56.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sbs MONOCLONAL ANTIBODY
3A2


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 122
ALA H 124
PHE H 156
LEU H 180
ASP H 183
None
0.69A 5mthA-1sbsH:
26.8
5mthA-1sbsH:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1seq MONOCLONAL ANTIBODY
MNAC13


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 112
ALA H 114
PHE H 146
LEU H 170
ASP H 173
None
0.65A 5mthA-1seqH:
27.4
5mthA-1seqH:
70.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sy6 OKT3 FAB HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 118
ALA H 120
PHE H 152
LEU H 176
None
0.25A 5mthA-1sy6H:
19.0
5mthA-1sy6H:
78.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t4k IMMUNOGLOBULIN IGG1,
HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER B 112
ALA B 114
PHE B 148
LEU B 178
ASP B 183
None
0.42A 5mthA-1t4kB:
27.7
5mthA-1t4kB:
68.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t66 IMMUNOGLOBULIN HEAVY
CHAIN


(Mus musculus)
no annotation 4 SER H 117
ALA H 119
PHE H 151
LEU H 175
None
0.30A 5mthA-1t66H:
26.2
5mthA-1t66H:
64.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1um4 ANTIBODY 21H3 H
CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 118
ALA H 120
PHE H 152
LEU H 176
None
0.41A 5mthA-1um4H:
27.1
5mthA-1um4H:
67.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vge TR1.9 FAB

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 121
ALA H 123
PHE H 155
LEU H 179
None
0.40A 5mthA-1vgeH:
27.6
5mthA-1vgeH:
60.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yed IGG1 FAB FRAGMENT
(D.2.4)


(Mus musculus)
no annotation 5 SER H 112
ALA H 116
PHE H 148
LEU H 172
ASP H 175
None
0.66A 5mthA-1yedH:
27.6
5mthA-1yedH:
84.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ztx HEAVY CHAIN OF E16
ANTIBODY


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 112
ALA H 114
PHE H 148
LEU H 178
None
0.41A 5mthA-1ztxH:
16.9
5mthA-1ztxH:
74.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ajx ANTIBODY 7A1 FAB'

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 112
ALA H 114
PHE H 148
LEU H 178
None
0.24A 5mthA-2ajxH:
19.7
5mthA-2ajxH:
70.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ck0 PROTEIN
(IMMUNOGLOBULIN
HEAVY CHAIN)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 116
ALA H 118
PHE H 150
LEU H 174
ASP H 177
None
0.68A 5mthA-2ck0H:
27.3
5mthA-2ck0H:
67.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g2r GREEN-FLUORESCENT
ANTIBODY
(11G10)-HEAVY CHAIN


(Mus musculus)
no annotation 4 SER H 112
ALA H 114
PHE H 148
LEU H 178
None
0.30A 5mthA-2g2rH:
29.0
5mthA-2g2rH:
73.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g60 ANTI-FLAG M2 FAB
HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 112
ALA H 114
PHE H 148
LEU H 178
ASP H 183
None
0.34A 5mthA-2g60H:
28.9
5mthA-2g60H:
79.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2mpa MN12H2
IGG2A-KAPPA,HEAVY
CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 120
ALA H 122
PHE H 154
LEU H 178
None
0.37A 5mthA-2mpaH:
26.5
5mthA-2mpaH:
73.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2or9 MONOCLONAL
ANTI-C-MYC ANTIBODY
9E10


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 112
ALA H 114
PHE H 146
LEU H 170
None
0.32A 5mthA-2or9H:
27.1
5mthA-2or9H:
71.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oz4 FAB FRAGMENT, HEAVY
CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 113
ALA H 115
PHE H 147
LEU H 171
ASP H 174
None
0.35A 5mthA-2oz4H:
27.8
5mthA-2oz4H:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pcp IMMUNOGLOBULIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER B 112
ALA B 114
PHE B 148
LEU B 178
ASP B 183
None
0.90A 5mthA-2pcpB:
27.1
5mthA-2pcpB:
81.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r1y FAB, ANTIBODY
FRAGMENT (IGG1K),
HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER B 110
ALA B 112
PHE B 144
LEU B 168
ASP B 171
None
0.37A 5mthA-2r1yB:
28.7
5mthA-2r1yB:
70.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9d ICSM 18-ANTI-PRP
THERAPEUTIC FAB
HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 115
ALA H 117
PHE H 148
LEU H 172
ASP H 175
None
0.33A 5mthA-2w9dH:
28.1
5mthA-2w9dH:
81.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xqy A13-D6.3 MONOCLONAL
ANTIBODY


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER G 112
ALA G 114
PHE G 146
LEU G 170
ASP G 173
None
0.33A 5mthA-2xqyG:
29.8
5mthA-2xqyG:
73.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER B 117
ALA B 119
PHE B 151
LEU B 175
ASP B 178
None
0.39A 5mthA-2z4qB:
28.5
5mthA-2z4qB:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d85 FAB OF ANTIBODY
7G10, HEAVY CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER B 114
ALA B 116
PHE B 148
LEU B 172
None
0.23A 5mthA-3d85B:
29.1
5mthA-3d85B:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e8u FAB 106.3 HEAVY
CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 112
ALA H 114
PHE H 148
LEU H 172
ASP H 175
None
0.46A 5mthA-3e8uH:
28.2
5mthA-3e8uH:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fo0 CATALYTIC ANTIBODY
FAB 13G5 IGG2B HEAVY
CHAIN CHIMERA


(Homo sapiens;
Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 120
ALA H 122
PHE H 154
LEU H 178
None
0.29A 5mthA-3fo0H:
26.9
5mthA-3fo0H:
52.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gnm JAA-F11 FAB ANTIBODY
FRAGMENT, HEAVY
CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 117
ALA H 119
PHE H 151
LEU H 175
None
0.35A 5mthA-3gnmH:
30.0
5mthA-3gnmH:
69.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hns CS-35 FAB HEAVY
CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 117
ALA H 119
PHE H 151
LEU H 175
None
0.32A 5mthA-3hnsH:
29.4
5mthA-3hnsH:
67.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ijs IMMUNOGLOBULIN HEAVY
CHAIN (IGG3)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER B 112
ALA B 114
PHE B 146
LEU B 170
None
0.26A 5mthA-3ijsB:
28.3
5mthA-3ijsB:
57.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iu4 CHP3 FAB HEAVY CHAIN

(Homo sapiens;
Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 112
ALA H 114
PHE H 146
LEU H 170
None
0.31A 5mthA-3iu4H:
27.0
5mthA-3iu4H:
46.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l7f H2L6 HEAVY CHAIN

(Homo sapiens)
no annotation 4 SER H 120
ALA H 122
PHE H 154
LEU H 178
None
0.30A 5mthA-3l7fH:
27.2
5mthA-3l7fH:
49.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qo0 FAB FRAGMENT OF
IMMUNOGLOBULIN G1
HEAVY CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER B 118
ALA B 120
PHE B 152
LEU B 176
None
0.31A 5mthA-3qo0B:
25.6
5mthA-3qo0B:
53.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ra7 FAB FRAGMENT, HEAVY
CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 124
ALA H 126
PHE H 158
LEU H 182
ASP H 185
None
0.80A 5mthA-3ra7H:
25.1
5mthA-3ra7H:
69.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt3 MOUSE MONOCLONAL
1GG1 FAB FRAGMENT,
KAPPA LIGHT CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 118
ALA H 120
PHE H 152
LEU H 176
ASP H 179
None
0.54A 5mthA-3tt3H:
28.8
5mthA-3tt3H:
81.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyr ANTIBODY FAB HEAVY
CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 116
ALA H 118
PHE H 150
LEU H 174
None
0.18A 5mthA-3uyrH:
27.7
5mthA-3uyrH:
62.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zkm FAB HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
5 SER C 115
ALA C 117
PHE C 149
LEU C 173
ASP C 176
None
0.37A 5mthA-3zkmC:
27.3
5mthA-3zkmC:
63.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 112
ALA H 114
PHE H 146
LEU H 170
None
0.40A 5mthA-4ag4H:
28.7
5mthA-4ag4H:
82.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bz1 FAB 3E31 HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 116
ALA H 118
PHE H 150
LEU H 174
None
0.33A 5mthA-4bz1H:
29.0
5mthA-4bz1H:
82.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d3c SFN68 FAB

(Oryctolagus
cuniculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 115
ALA H 117
PHE H 149
LEU H 173
None
0.30A 5mthA-4d3cH:
27.1
5mthA-4d3cH:
55.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d9q ANTI-FACTOR D, HEAVY
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER E 120
ALA E 122
PHE E 154
LEU E 178
None
0.29A 5mthA-4d9qE:
28.6
5mthA-4d9qE:
59.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4edx HEAVY CHAIN OF FAB
OF MURINE ANTI-NGF


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER B 112
ALA B 114
PHE B 148
LEU B 178
None
0.28A 5mthA-4edxB:
27.4
5mthA-4edxB:
63.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g6k HEAVY CHAIN OF
GEVOKIZUMAB ANTIBODY
BINDING FRAGMENT


(Homo sapiens;
Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 119
ALA H 121
PHE H 153
LEU H 177
None
0.35A 5mthA-4g6kH:
25.9
5mthA-4g6kH:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i77 LEBRIKIZUMAB HEAVY
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 112
ALA H 114
PHE H 146
LEU H 170
None
0.40A 5mthA-4i77H:
18.3
5mthA-4i77H:
50.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jlr MOTAVIZUMAB FAB
HEAVY CHAIN


(Homo sapiens)
no annotation 4 SER H 112
ALA H 114
PHE H 146
LEU H 170
None
0.30A 5mthA-4jlrH:
26.8
5mthA-4jlrH:
49.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jn2 ANTI DABIGATRAN FAB

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER B 122
ALA B 124
PHE B 156
LEU B 180
None
0.38A 5mthA-4jn2B:
25.3
5mthA-4jn2B:
55.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kvc IG HEAVY CHAIN V
REGION MOPC 21, IGH
PROTEIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 119
ALA H 121
PHE H 153
LEU H 177
ASP H 180
None
0.89A 5mthA-4kvcH:
26.3
5mthA-4kvcH:
65.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kxz GC1008 HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 119
ALA H 121
PHE H 153
LEU H 177
None
0.35A 5mthA-4kxzH:
27.1
5mthA-4kxzH:
61.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l5f HEAVY CHAIN OF E106
ANTIBODY (VH AND CH1
OF IGG2C)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 112
ALA H 114
PHE H 146
LEU H 170
None
0.20A 5mthA-4l5fH:
30.1
5mthA-4l5fH:
75.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lri MSL-109 HEAVY CHAIN

(Homo sapiens)
no annotation 4 SER P 129
ALA P 131
PHE P 163
LEU P 187
None
0.32A 5mthA-4lriP:
25.7
5mthA-4lriP:
53.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m1g MURINE IGG2A A27D7
HEAVY CHAIN FAB
DOMAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 117
ALA H 119
PHE H 151
LEU H 175
ASP H 178
None
1.09A 5mthA-4m1gH:
27.6
5mthA-4m1gH:
61.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mhh H5M9 ANTIBODY, HEAVY
CHAIN (IGG1)


(Mus musculus)
no annotation 5 SER H 112
ALA H 114
PHE H 148
LEU H 178
ASP H 183
None
0.77A 5mthA-4mhhH:
28.2
5mthA-4mhhH:
81.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nzr PGT135 HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 112
ALA H 114
PHE H 148
LEU H 178
None
0.41A 5mthA-4nzrH:
24.6
5mthA-4nzrH:
51.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o4y 2095-2 HEAVY CHAIN

(Homo sapiens;
Oryctolagus
cuniculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 113
ALA H 115
PHE H 147
LEU H 171
None
0.37A 5mthA-4o4yH:
25.4
5mthA-4o4yH:
52.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uom FAB FRAGMENT HEAVY
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 115
ALA H 117
PHE H 149
LEU H 173
None
0.39A 5mthA-4uomH:
27.6
5mthA-4uomH:
85.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xzu 3E6 ANTIBODY FAB
HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER A 115
ALA A 117
PHE A 149
LEU A 173
None
0.31A 5mthA-4xzuA:
27.2
5mthA-4xzuA:
66.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yue S4B6 FAB HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 125
ALA H 127
PHE H 159
LEU H 183
None
0.26A 5mthA-4yueH:
28.0
5mthA-4yueH:
73.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zxb FAB 83-7 HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER A 117
ALA A 119
PHE A 151
LEU A 175
None
0.41A 5mthA-4zxbA:
28.5
5mthA-4zxbA:
71.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5aum HEAVY CHAIN OF FAB
FRAGMENT


(Rattus)
no annotation 4 SER H 112
ALA H 114
PHE H 146
LEU H 170
None
0.33A 5mthA-5aumH:
18.4
5mthA-5aumH:
57.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c0n FAB CA33 HEAVY CHAIN

(Oryctolagus
cuniculus)
no annotation 4 SER H 119
ALA H 121
PHE H 153
LEU H 177
None
0.33A 5mthA-5c0nH:
26.9
5mthA-5c0nH:
71.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER A 112
ALA A 114
PHE A 146
LEU A 170
None
0.36A 5mthA-5dq9A:
25.8
5mthA-5dq9A:
65.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dyo FAB 43.1 HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER A 112
ALA A 114
PHE A 146
LEU A 170
None
0.39A 5mthA-5dyoA:
27.0
5mthA-5dyoA:
78.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ea0 HEAVY CHAIN OF
ANTIBODY 7968 FAB
FRAGMENT


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 114
ALA H 116
PHE H 148
LEU H 172
None
0.41A 5mthA-5ea0H:
26.9
5mthA-5ea0H:
53.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ebw ANTIBODY FAB
FRAGMENT LIGHT CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER A 117
ALA A 119
PHE A 151
LEU A 175
None
0.33A 5mthA-5ebwA:
28.6
5mthA-5ebwA:
82.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eoc FAB FRAGMENT (HEAVY
CHAIN)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 118
ALA H 120
PHE H 150
LEU H 174
None
0.29A 5mthA-5eocH:
29.0
5mthA-5eocH:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER H 115
ALA H 117
PHE H 149
LEU H 173
ASP H 176
None
0.55A 5mthA-5eorH:
26.7
5mthA-5eorH:
62.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezj FAB C12 HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER A 132
ALA A 134
PHE A 166
LEU A 190
None
0.41A 5mthA-5ezjA:
19.1
5mthA-5ezjA:
66.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fgc ANTI-HCV E2 FAB
HC33.8 HEAVY CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER E 126
ALA E 128
PHE E 160
LEU E 184
None
0.39A 5mthA-5fgcE:
26.7
5mthA-5fgcE:
53.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hdq FAB HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 112
ALA H 114
PHE H 146
LEU H 170
None
0.29A 5mthA-5hdqH:
30.0
5mthA-5hdqH:
75.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i73 8B6 ANTIBODY, HEAVY
CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER B 137
ALA B 139
PHE B 171
LEU B 195
None
0.34A 5mthA-5i73B:
28.3
5mthA-5i73B:
75.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i8k HHH1 FAB HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 115
ALA H 117
PHE H 149
LEU H 173
None
0.41A 5mthA-5i8kH:
26.1
5mthA-5i8kH:
52.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i8o HMM5 ANTIBODY HEAVY
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 115
ALA H 117
PHE H 149
LEU H 173
None
0.39A 5mthA-5i8oH:
25.9
5mthA-5i8oH:
50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mev FAB HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 118
ALA H 120
PHE H 152
LEU H 176
None
0.28A 5mthA-5mevH:
26.7
5mthA-5mevH:
70.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5myx FAB C#24 HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER B 114
ALA B 116
PHE B 148
LEU B 172
None
0.29A 5mthA-5myxB:
29.9
5mthA-5myxB:
86.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nb5 DESIGN OF ANTIBODIES

(Escherichia
coli)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 115
ALA H 117
PHE H 149
LEU H 173
None
0.37A 5mthA-5nb5H:
25.0
5mthA-5nb5H:
62.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o14 FAB 1A12 HEAVY CHAIN

(Homo sapiens)
no annotation 4 SER C 121
ALA C 123
PHE C 155
LEU C 179
None
0.38A 5mthA-5o14C:
28.8
5mthA-5o14C:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5obf FAB HEAVY CHAIN

(Mus musculus)
no annotation 4 SER H 111
ALA H 113
PHE H 145
LEU H 169
None
0.28A 5mthA-5obfH:
27.6
5mthA-5obfH:
71.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6m HEAVY CHAIN OF FAB
FRAGMENT OF RABBIT
ANTI-HIV1 GP120 V3
MAB 10A3


(Oryctolagus
cuniculus)
no annotation 4 SER H 108
ALA H 110
PHE H 142
LEU H 166
None
0.39A 5mthA-5v6mH:
26.3
5mthA-5v6mH:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vgj VRC38.01 FAB HEAVY
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 112
ALA H 114
PHE H 146
LEU H 170
None
0.28A 5mthA-5vgjH:
25.4
5mthA-5vgjH:
51.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vic FAB HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H 112
ALA H 114
PHE H 146
LEU H 170
None
0.36A 5mthA-5vicH:
17.2
5mthA-5vicH:
54.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN


(Mus musculus)
no annotation 4 SER H 118
ALA H 120
PHE H 152
LEU H 176
None
0.17A 5mthA-5vxrH:
26.4
5mthA-5vxrH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a0x ANTIBODY 13D4, FAB
HEAVY CHAIN


(Mus musculus)
no annotation 4 SER A 112
ALA A 114
PHE A 146
LEU A 170
None
0.33A 5mthA-6a0xA:
28.0
5mthA-6a0xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aq7 POM6 FAB HEAVY CHAIN

(Mus musculus)
no annotation 5 SER H 114
ALA H 116
PHE H 147
LEU H 171
ASP H 174
None
0.28A 5mthA-6aq7H:
29.3
5mthA-6aq7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bli CB002.5 FAB HEAVY
CHAIN


(Homo sapiens)
no annotation 4 SER A 112
ALA A 114
PHE A 146
LEU A 170
None
0.30A 5mthA-6bliA:
26.3
5mthA-6bliA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eyn -

(-)
no annotation 4 SER H 118
ALA H 120
PHE H 152
LEU H 176
None
0.31A 5mthA-6eynH:
17.6
5mthA-6eynH:
undetectable