SIMILAR PATTERNS OF AMINO ACIDS FOR 5MTH_A_ACTA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfz HYDROGENASE 2
MATURATION PROTEASE

(Escherichia
coli) 		PF01750
(HycI) 		4 THR A 131
VAL A 134
PRO A  71
THR A 133
 None
 1.32A 5mthA-1cfzA:
0.0
5mthH-1cfzA:
0.0		 5mthA-1cfzA:
25.94
5mthH-1cfzA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epv ALANINE RACEMASE

(Geobacillus
stearothermophilus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 THR A  32
VAL A 218
PRO A 211
THR A 214
 None
 1.03A 5mthA-1epvA:
0.0
5mthH-1epvA:
0.0		 5mthA-1epvA:
19.72
5mthH-1epvA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6o TATD-RELATED
DEOXYRIBONUCLEASE

(Thermotoga
maritima) 		PF01026
(TatD_DNase) 		4 THR A 226
VAL A 176
PRO A 207
THR A 177
 None
 1.37A 5mthA-1j6oA:
0.0
5mthH-1j6oA:
0.0		 5mthA-1j6oA:
22.18
5mthH-1j6oA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 THR A 437
VAL A 452
PRO A 455
THR A 453
 None
 1.33A 5mthA-1nneA:
0.0
5mthH-1nneA:
0.0		 5mthA-1nneA:
12.45
5mthH-1nneA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean pod mottle
virus) 		PF02247
(Como_LCP) 		4 THR 2  40
VAL 2  37
PRO 2  33
THR 2  36
 None
 1.39A 5mthA-1pgw2:
0.0
5mthH-1pgw2:
0.9		 5mthA-1pgw2:
22.16
5mthH-1pgw2:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zov MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
NS-129) 		PF01266
(DAO) 		4 THR A  85
VAL A 146
PRO A 257
THR A  87
 None
 1.42A 5mthA-1zovA:
0.0
5mthH-1zovA:
0.0		 5mthA-1zovA:
21.00
5mthH-1zovA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f96 RIBONUCLEASE T

(Pseudomonas
aeruginosa) 		PF00929
(RNase_T) 		4 THR A 199
VAL A  33
PRO A  66
THR A  54
 None
 1.41A 5mthA-2f96A:
0.0
5mthH-2f96A:
0.0		 5mthA-2f96A:
20.70
5mthH-2f96A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i32 ANTI-SILENCING
FACTOR 1 PARALOG A
HISTONE REGULATORY
HOMOLOG A

(Homo sapiens;
Homo sapiens) 		PF04729
(ASF1_hist_chap)
PF09453
(HIRA_B) 		4 THR E 452
VAL E 450
PRO A  64
THR E 462
 None
 1.21A 5mthA-2i32E:
undetectable
5mthH-2i32E:
undetectable		 5mthA-2i32E:
18.54
5mthH-2i32E:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		4 THR A 119
VAL A 117
PRO A  73
THR A  96
 None
 1.47A 5mthA-2isqA:
undetectable
5mthH-2isqA:
undetectable		 5mthA-2isqA:
22.12
5mthH-2isqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9t DING

(Pseudomonas
fluorescens) 		PF12849
(PBP_like_2) 		4 THR A  92
VAL A  90
PRO A  10
THR A 293
 None
 1.36A 5mthA-2q9tA:
undetectable
5mthH-2q9tA:
undetectable		 5mthA-2q9tA:
21.47
5mthH-2q9tA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1

(Homo sapiens) 		PF02144
(Rad1) 		4 THR C 218
VAL C 220
PRO C 186
THR C 180
 None
 1.25A 5mthA-3a1jC:
0.6
5mthH-3a1jC:
0.6		 5mthA-3a1jC:
20.48
5mthH-3a1jC:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 THR A 348
VAL A 379
PRO A 158
THR A 350
 None
 1.49A 5mthA-3ddrA:
undetectable
5mthH-3ddrA:
undetectable		 5mthA-3ddrA:
12.08
5mthH-3ddrA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go9 INSULINASE FAMILY
PROTEASE

(Yersinia pestis) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 THR A  65
VAL A  63
PRO A  82
THR A 121
 None
 1.26A 5mthA-3go9A:
0.4
5mthH-3go9A:
0.2		 5mthA-3go9A:
17.96
5mthH-3go9A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kop UNCHARACTERIZED
PROTEIN

(Arthrobacter
sp. FB24) 		PF12903
(DUF3830) 		4 THR A 106
VAL A 108
PRO A  64
THR A  82
 None
 1.15A 5mthA-3kopA:
undetectable
5mthH-3kopA:
undetectable		 5mthA-3kopA:
20.75
5mthH-3kopA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qrq PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB192

(Thermus
thermophilus) 		PF08798
(CRISPR_assoc) 		4 THR A  63
VAL A  61
PRO A  82
THR A   4
 None
 1.44A 5mthA-3qrqA:
undetectable
5mthH-3qrqA:
undetectable		 5mthA-3qrqA:
19.42
5mthH-3qrqA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr2 CYSTEINE SYNTHASE

(Mycobacterium
marinum) 		PF00291
(PALP) 		4 THR A 116
VAL A 114
PRO A  70
THR A  93
 None
 1.42A 5mthA-3rr2A:
undetectable
5mthH-3rr2A:
undetectable		 5mthA-3rr2A:
22.64
5mthH-3rr2A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		4 THR A 880
VAL A 633
PRO A 605
THR A 631
 None
 1.16A 5mthA-3ux8A:
undetectable
5mthH-3ux8A:
undetectable		 5mthA-3ux8A:
13.25
5mthH-3ux8A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9v PHOSPHATE-BINDING
PROTEIN

(unidentified
prokaryotic
organism) 		PF12849
(PBP_like_2) 		4 THR A  91
VAL A  89
PRO A  10
THR A 299
 None
 1.37A 5mthA-3w9vA:
undetectable
5mthH-3w9vA:
undetectable		 5mthA-3w9vA:
19.06
5mthH-3w9vA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN

(Saccharomyces
cerevisiae) 		PF00248
(Aldo_ket_red) 		4 THR A 151
VAL A 153
PRO A 324
THR A 159
 None
 1.00A 5mthA-4ijrA:
undetectable
5mthH-4ijrA:
undetectable		 5mthA-4ijrA:
21.60
5mthH-4ijrA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kps HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 THR A 217
VAL A 188
PRO A 200
THR A 191
 None
 1.35A 5mthA-4kpsA:
undetectable
5mthH-4kpsA:
undetectable		 5mthA-4kpsA:
19.63
5mthH-4kpsA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwf ENVELOPE
GLYCOPROTEIN E2

(Hepacivirus C) 		PF01560
(HCV_NS1) 		4 THR C 561
VAL C 563
PRO C 601
THR C 553
 None
 1.38A 5mthA-4mwfC:
undetectable
5mthH-4mwfC:
undetectable		 5mthA-4mwfC:
20.34
5mthH-4mwfC:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		4 THR A 111
VAL A 104
PRO A 245
THR A 101
 None
 1.43A 5mthA-4pdhA:
undetectable
5mthH-4pdhA:
undetectable		 5mthA-4pdhA:
20.52
5mthH-4pdhA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u65 PUTATIVE CYSTINE
PROTEASE

(Pseudomonas
fluorescens) 		PF06035
(Peptidase_C93) 		4 THR E 174
VAL E 172
PRO E 204
THR E 159
 None
 1.17A 5mthA-4u65E:
undetectable
5mthH-4u65E:
undetectable		 5mthA-4u65E:
21.03
5mthH-4u65E:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uug AMINE TRANSAMINASE

(Aspergillus
fumigatus) 		PF01063
(Aminotran_4) 		4 THR A 204
VAL A 166
PRO A 201
THR A 163
 None
 1.41A 5mthA-4uugA:
undetectable
5mthH-4uugA:
undetectable		 5mthA-4uugA:
21.65
5mthH-4uugA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli) 		PF00245
(Alk_phosphatase) 		4 THR A 107
VAL A 113
PRO A 130
THR A 111
 None
None
GOL  A 506 ( 4.8A)
None
 1.49A 5mthA-4yr1A:
undetectable
5mthH-4yr1A:
undetectable		 5mthA-4yr1A:
19.51
5mthH-4yr1A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		4 THR A 455
VAL A 459
PRO A 367
THR A 458
 None
 1.49A 5mthA-5djqA:
undetectable
5mthH-5djqA:
undetectable		 5mthA-5djqA:
19.75
5mthH-5djqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 THR B 521
VAL B 519
PRO B 544
THR B 422
 None
 1.46A 5mthA-5l3qB:
undetectable
5mthH-5l3qB:
undetectable		 5mthA-5l3qB:
16.22
5mthH-5l3qB:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myb ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF00041
(fn3) 		4 THR A 706
VAL A 730
PRO A 733
THR A 731
 None
 1.46A 5mthA-5mybA:
5.2
5mthH-5mybA:
undetectable		 5mthA-5mybA:
20.71
5mthH-5mybA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Brucella canis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 THR A 144
VAL A 161
PRO A 172
THR A 163
 None
 1.39A 5mthA-5u2aA:
undetectable
5mthH-5u2aA:
undetectable		 5mthA-5u2aA:
16.52
5mthH-5u2aA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5

(Aquareovirus C) 		no annotation 4 THR B 350
VAL B 348
PRO B 291
THR B 467
 None
 1.32A 5mthA-5zvtB:
undetectable
5mthH-5zvtB:
undetectable		 5mthA-5zvtB:
undetectable
5mthH-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0g PIRIN FAMILY PROTEIN

(Acinetobacter
baumannii) 		no annotation 4 THR A  95
VAL A 123
PRO A  75
THR A 121
 None
 1.39A 5mthA-6d0gA:
1.9
5mthH-6d0gA:
undetectable		 5mthA-6d0gA:
undetectable
5mthH-6d0gA:
undetectable