SIMILAR PATTERNS OF AMINO ACIDS FOR 5MSD_A_BEZA1202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1btc BETA-AMYLASE

(Glycine max) 		PF01373
(Glyco_hydro_14) 		4 ILE A 299
PHE A 200
SER A 357
ALA A 310
 None
GLC  A 499 ( 3.6A)
None
None
 1.21A 5msdA-1btcA:
2.6		 5msdA-1btcA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clx XYLANASE A

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10) 		4 HIS A 107
ILE A 108
PHE A 150
ALA A 163
 None
 1.26A 5msdA-1clxA:
2.6		 5msdA-1clxA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 ILE A 338
PHE A 341
SER A  26
ALA A 262
 None
 0.98A 5msdA-1dj3A:
1.2		 5msdA-1dj3A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA

(Enterococcus
faecium) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 ILE B  41
PHE B 112
SER B  96
ALA B   7
 None
 0.98A 5msdA-1e4eB:
undetectable		 5msdA-1e4eB:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fta FRUCTOSE-1,6-BISPHOS
PHATASE

(Homo sapiens) 		PF00316
(FBPase) 		4 HIS A 311
ILE A 310
SER A  96
ALA A 152
 None
 1.16A 5msdA-1ftaA:
undetectable		 5msdA-1ftaA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imh NUCLEAR FACTOR OF
ACTIVATED T CELLS 5

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 HIS C 216
ILE C 311
SER C 228
ALA C 270
 None
 1.18A 5msdA-1imhC:
undetectable		 5msdA-1imhC:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iz1 LYSR-TYPE REGULATORY
PROTEIN

(Cupriavidus
necator) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 HIS A 142
ILE A 280
SER A 123
ALA A 120
 None
 1.20A 5msdA-1iz1A:
undetectable		 5msdA-1iz1A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT

(Methylophilus
methylotrophus;
Methylophilus
methylotrophus) 		PF01012
(ETF)
PF01012
(ETF) 		4 HIS C 142
ILE C 132
PHE D  70
ALA D 103
 None
 1.18A 5msdA-1o94C:
2.4		 5msdA-1o94C:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		4 ILE A 214
PHE A 205
SER A 247
ALA A 217
 None
 1.15A 5msdA-1qafA:
undetectable		 5msdA-1qafA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw9 CHONDROITIN AC LYASE

(Paenarthrobacter
aurescens) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ILE A 103
PHE A  61
SER A  47
ALA A 102
 None
 1.24A 5msdA-1rw9A:
undetectable		 5msdA-1rw9A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA

(Bacillus
subtilis) 		PF00496
(SBP_bac_5) 		4 ILE A  86
PHE A 208
SER A  54
ALA A  70
 None
 1.20A 5msdA-1xocA:
undetectable		 5msdA-1xocA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zor ISOCITRATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00180
(Iso_dh) 		4 ILE A 203
PHE A 108
SER A 191
ALA A 196
 None
 0.99A 5msdA-1zorA:
undetectable		 5msdA-1zorA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		4 ILE A 175
PHE A  30
SER A  41
ALA A 168
 None
 1.20A 5msdA-2braA:
undetectable		 5msdA-2braA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		4 ILE A 154
PHE A 141
SER A 103
ALA A 156
 None
 1.17A 5msdA-2bwgA:
3.6		 5msdA-2bwgA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzn GMP REDUCTASE 2

(Homo sapiens) 		PF00478
(IMPDH) 		4 ILE A 154
PHE A 141
SER A 103
ALA A 156
 None
 1.15A 5msdA-2bznA:
3.5		 5msdA-2bznA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0g WINDBEUTEL PROTEIN

(Drosophila
melanogaster) 		PF07749
(ERp29)
PF07912
(ERp29_N) 		4 HIS A1070
ILE A1078
PHE A1042
ALA A1079
 None
 1.07A 5msdA-2c0gA:
2.4		 5msdA-2c0gA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exa PENICILLIN-BINDING
PROTEIN 4

(Escherichia
coli) 		PF02113
(Peptidase_S13) 		4 ILE A  67
PHE A 315
SER A 333
ALA A  71
 None
 1.02A 5msdA-2exaA:
undetectable		 5msdA-2exaA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj3 NITROGEN FIXATION
REGULATORY PROTEIN

(Azotobacter
vinelandii) 		PF00989
(PAS) 		4 HIS A 133
ILE A  57
SER A  39
ALA A  53
 FAD  A 500 ( 4.8A)
None
FAD  A 500 ( 4.7A)
None
 1.27A 5msdA-2gj3A:
undetectable		 5msdA-2gj3A:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 ILE A  33
PHE A  53
SER A  62
ALA A  21
 None
 1.14A 5msdA-2hyjA:
undetectable		 5msdA-2hyjA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iir ACETATE KINASE

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		4 HIS A  59
ILE A  34
SER A   8
ALA A  31
 None
 1.03A 5msdA-2iirA:
undetectable		 5msdA-2iirA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1

(Anopheles
gambiae) 		PF00481
(PP2C) 		4 HIS A 206
ILE A 181
SER A 203
ALA A 166
 None
 1.28A 5msdA-2irmA:
undetectable		 5msdA-2irmA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n8a POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		PF00645
(zf-PARP) 		4 HIS A  53
ILE A  28
SER A  25
ALA A  19
 ZN  A1000 (-3.1A)
None
None
None
 1.28A 5msdA-2n8aA:
undetectable		 5msdA-2n8aA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 HIS B1317
ILE B1313
SER B1297
ALA B1303
 None
 1.01A 5msdA-2o8eB:
undetectable		 5msdA-2o8eB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00215
(OMPdecase) 		4 ILE A  47
PHE A 223
SER A 205
ALA A  51
 None
 1.11A 5msdA-2p1fA:
2.5		 5msdA-2p1fA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ILE A 382
PHE A 290
SER A 376
ALA A 316
 None
 1.03A 5msdA-2p54A:
undetectable		 5msdA-2p54A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)

(Homo sapiens) 		PF00215
(OMPdecase) 		4 ILE A 236
PHE A 412
SER A 394
ALA A 240
 None
 1.10A 5msdA-2qcmA:
2.4		 5msdA-2qcmA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		4 ILE A 349
PHE A 117
SER A 357
ALA A  96
 None
 1.22A 5msdA-2qneA:
undetectable		 5msdA-2qneA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 HIS A 450
ILE A 317
PHE A 442
ALA A 351
 None
 0.81A 5msdA-2qo3A:
undetectable		 5msdA-2qo3A:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		4 ILE A 263
PHE A 353
SER A 394
ALA A 400
 None
None
HAS  A1016 (-3.7A)
None
 1.09A 5msdA-2yevA:
undetectable		 5msdA-2yevA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		4 ILE A  85
PHE A 141
SER A 169
ALA A  88
 None
 1.23A 5msdA-2ywdA:
undetectable		 5msdA-2ywdA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0d PUTATIVE NITRITE
REDUCTASE NADPH
(SMALL SUBUNIT)
OXIDOREDUCTASE
PROTEIN

(Vibrio
parahaemolyticus) 		PF13806
(Rieske_2) 		4 ILE A  59
PHE A  33
SER A  56
ALA A  70
 None
 1.19A 5msdA-3c0dA:
undetectable		 5msdA-3c0dA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8t FUMARATE LYASE

(Chelativorans
sp. BNC1) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 ILE A 348
PHE A 184
SER A 257
ALA A 352
 None
 1.27A 5msdA-3c8tA:
undetectable		 5msdA-3c8tA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlv SIGNAL RECOGNITION
PARTICLE 19 KDA
PROTEIN

(Pyrococcus
furiosus) 		no annotation 4 ILE B  37
PHE B  46
SER B  84
ALA B  40
 None
 1.24A 5msdA-3dlvB:
undetectable		 5msdA-3dlvB:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		4 HIS A 163
ILE A 159
PHE A  17
ALA A 223
 None
None
KAP  A 451 ( 4.1A)
KAP  A 451 ( 4.2A)
 1.05A 5msdA-3du4A:
undetectable		 5msdA-3du4A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA

(Pseudomonas
aeruginosa) 		PF05141
(DIT1_PvcA) 		4 HIS A 255
ILE A 254
SER A 235
ALA A  64
 PO4  A 329 (-4.0A)
None
PO4  A 329 ( 4.5A)
None
 1.27A 5msdA-3e59A:
undetectable		 5msdA-3e59A:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewk SENSOR PROTEIN

(Methylococcus
capsulatus) 		PF13426
(PAS_9) 		4 HIS A 132
ILE A 109
SER A 193
ALA A 112
 FAD  A 326 (-3.4A)
None
FAD  A 326 ( 4.1A)
None
 1.26A 5msdA-3ewkA:
undetectable		 5msdA-3ewkA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnd CHITINASE

(Bacteroides
thetaiotaomicron) 		PF00704
(Glyco_hydro_18) 		4 ILE A 111
PHE A  64
SER A  99
ALA A 104
 None
 1.15A 5msdA-3fndA:
undetectable		 5msdA-3fndA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnr ARGINYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00750
(tRNA-synt_1d)
PF05746
(DALR_1) 		4 ILE A 164
PHE A 204
SER A 212
ALA A 196
 None
 1.09A 5msdA-3fnrA:
2.3		 5msdA-3fnrA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A 659
PHE A 674
SER A 666
ALA A 692
 None
 1.22A 5msdA-3ho8A:
1.7		 5msdA-3ho8A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4j AMINOTRANSFERASE,
CLASS III

(Deinococcus
radiodurans) 		PF00202
(Aminotran_3) 		4 ILE A 256
PHE A 290
SER A 104
ALA A 109
 None
 1.10A 5msdA-3i4jA:
2.6		 5msdA-3i4jA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifc FRUCTOSE-1,6-BISPHOS
PHATASE ISOZYME 2

(Homo sapiens) 		PF00316
(FBPase) 		4 HIS A 311
ILE A 310
SER A  96
ALA A 152
 None
 1.16A 5msdA-3ifcA:
undetectable		 5msdA-3ifcA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd3 PHOSPHOSERINE
PHOSPHOHYDROLASE-LIK
E PROTEIN

(Francisella
tularensis) 		PF12710
(HAD) 		4 ILE A 123
PHE A   8
SER A 108
ALA A 113
 None
 1.01A 5msdA-3kd3A:
2.2		 5msdA-3kd3A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lao ENOYL-COA
HYDRATASE/ISOMERASE

(Pseudomonas
aeruginosa) 		PF00378
(ECH_1) 		4 HIS A 137
ILE A 167
PHE A 173
ALA A 163
 None
 0.98A 5msdA-3laoA:
undetectable		 5msdA-3laoA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE

(Listeria
monocytogenes) 		PF00198
(2-oxoacid_dh) 		4 HIS A 211
ILE A 209
SER A 383
ALA A 353
 CL  A   1 (-4.3A)
None
None
None
 1.25A 5msdA-3maeA:
undetectable		 5msdA-3maeA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n00 REV-ERBA-ALPHA
NUCLEAR RECEPTOR
COREPRESSOR 1

(Homo sapiens;
Homo sapiens) 		PF00104
(Hormone_recep)
no annotation 		4 HIS B2054
ILE B2058
SER A 440
ALA A 446
 None
 1.14A 5msdA-3n00B:
undetectable		 5msdA-3n00B:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na8 PUTATIVE
DIHYDRODIPICOLINATE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00701
(DHDPS) 		4 HIS A 195
ILE A 191
PHE A 207
ALA A 218
 None
 0.91A 5msdA-3na8A:
4.0		 5msdA-3na8A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of4 NITROREDUCTASE

(Idiomarina
loihiensis) 		PF00881
(Nitroreductase) 		4 ILE A  21
PHE A  16
SER A 152
ALA A  74
 None
 1.23A 5msdA-3of4A:
undetectable		 5msdA-3of4A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Staphylococcus
aureus) 		PF03099
(BPL_LplA_LipB)
PF08279
(HTH_11) 		4 ILE A 206
PHE A 109
SER A 101
ALA A 204
 None
 0.86A 5msdA-3rkxA:
undetectable		 5msdA-3rkxA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8i PURINE NUCLEOSIDASE,
(IUNH-2)

(Sulfolobus
solfataricus) 		PF01156
(IU_nuc_hydro) 		4 ILE A 235
PHE A 296
SER A 239
ALA A 189
 None
 1.24A 5msdA-3t8iA:
undetectable		 5msdA-3t8iA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 ILE A 920
PHE A 949
SER A 487
ALA A 923
 None
 1.19A 5msdA-3u44A:
2.3		 5msdA-3u44A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 ILE A 253
PHE A 264
SER A 242
ALA A 237
 None
 1.19A 5msdA-3zh4A:
undetectable		 5msdA-3zh4A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		4 HIS A 339
ILE A 151
SER A 257
ALA A 155
 None
 1.22A 5msdA-4c4aA:
3.3		 5msdA-4c4aA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Mycoplasma
penetrans) 		PF00145
(DNA_methylase) 		4 ILE A  51
PHE A  62
SER A  99
ALA A 104
 None
 1.07A 5msdA-4dkjA:
2.9		 5msdA-4dkjA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drt DE NOVO DESIGNED
SERINE HYDROLASE,
OR89

(synthetic
construct) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 HIS A  48
ILE A 107
SER A 152
ALA A 115
 None
 1.13A 5msdA-4drtA:
undetectable		 5msdA-4drtA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 HIS A 232
ILE A 215
PHE A 263
ALA A 202
 0SF  A 610 (-3.3A)
0SF  A 610 (-3.4A)
0SF  A 610 ( 4.1A)
0SF  A 610 (-2.6A)
 1.18A 5msdA-4f2aA:
undetectable		 5msdA-4f2aA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8

(Thermus
thermophilus) 		no annotation 4 ILE H  88
PHE H 244
SER H 139
ALA H 132
 None
 1.05A 5msdA-4he8H:
undetectable		 5msdA-4he8H:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyj RHODOPSIN

(Exiguobacterium
sibiricum) 		PF01036
(Bac_rhodopsin) 		4 HIS A  57
ILE A  81
PHE A  15
ALA A  64
 None
LFA  A 305 ( 4.5A)
None
None
 1.26A 5msdA-4hyjA:
undetectable		 5msdA-4hyjA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j16 NAD/NADP
TRANSHYDROGENASE
ALPHA SUBUNIT 1

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 ILE A 253
PHE A 155
SER A 151
ALA A 144
 None
 1.25A 5msdA-4j16A:
3.7		 5msdA-4j16A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Vibrio cholerae) 		no annotation 4 ILE D 319
PHE D 400
SER D 408
ALA D 303
 None
 1.18A 5msdA-4jrmD:
undetectable		 5msdA-4jrmD:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Brachyspira
murdochii) 		PF13407
(Peripla_BP_4) 		4 ILE A 297
PHE A  60
SER A  32
ALA A 301
 None
 1.25A 5msdA-4kqcA:
4.4		 5msdA-4kqcA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		4 HIS A  13
ILE A  16
PHE A  41
ALA A  64
 None
 1.23A 5msdA-4kriA:
3.0		 5msdA-4kriA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN E

(Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox) 		4 ILE B 282
PHE B 216
SER B 265
ALA B 272
 None
 1.20A 5msdA-4p1cB:
undetectable		 5msdA-4p1cB:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht TYPE II SECRETION
SYSTEM PROTEIN L

(Vibrio
vulnificus) 		PF05134
(T2SSL) 		4 HIS X 162
ILE X 149
SER X 168
ALA X 151
 None
 1.18A 5msdA-4phtX:
undetectable		 5msdA-4phtX:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		4 HIS A 570
ILE A 542
SER A 566
ALA A 504
 None
 1.17A 5msdA-4pspA:
undetectable		 5msdA-4pspA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE

(Neurospora
crassa) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		4 ILE A 577
PHE A 375
SER A 404
ALA A 599
 None
 1.23A 5msdA-4qi7A:
undetectable		 5msdA-4qi7A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ILE A 311
PHE A 296
SER A 340
ALA A 309
 None
 1.06A 5msdA-4r16A:
3.3		 5msdA-4r16A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3n CALCIUM-REGULATED
ACTIN-BUNDLING
PROTEIN

(Dictyostelium
discoideum) 		no annotation 4 HIS A 180
ILE A 183
SER A 271
ALA A 275
 None
 1.09A 5msdA-4x3nA:
undetectable		 5msdA-4x3nA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yba REGULATORY PROTEIN C

(Klebsiella
pneumoniae) 		PF01381
(HTH_3) 		4 ILE A  57
PHE A  68
SER A  17
ALA A  60
 ILE  A  57 ( 0.7A)
PHE  A  68 ( 1.3A)
SER  A  17 ( 0.0A)
ALA  A  60 ( 0.0A)
 1.25A 5msdA-4ybaA:
undetectable		 5msdA-4ybaA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypt REPLICASE
POLYPROTEIN 1AB

(Murine
coronavirus) 		PF08715
(Viral_protease) 		4 ILE A1603
PHE A1595
SER A1582
ALA A1598
 None
 1.23A 5msdA-4yptA:
undetectable		 5msdA-4yptA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2

(Homo sapiens) 		PF00043
(GST_C) 		4 HIS B 225
ILE B 233
PHE B 218
ALA B 277
 None
None
GOL  B1321 ( 4.9A)
None
 1.22A 5msdA-5a1nB:
undetectable		 5msdA-5a1nB:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 NEQ263

(Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab) 		4 ILE B 344
PHE B 383
SER B 117
ALA B 340
 None
 1.28A 5msdA-5bn4B:
undetectable		 5msdA-5bn4B:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dan 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Thermotoga
maritima) 		PF00248
(Aldo_ket_red) 		4 HIS A 221
ILE A 260
SER A 263
ALA A 231
 None
 1.25A 5msdA-5danA:
2.5		 5msdA-5danA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		4 ILE A 346
PHE A 116
SER A  95
ALA A 385
 None
 1.15A 5msdA-5ddsA:
4.0		 5msdA-5ddsA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 4 ILE B 137
PHE B 167
SER B 127
ALA B 120
 None
 1.27A 5msdA-5dlqB:
undetectable		 5msdA-5dlqB:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ILE C 159
PHE C  47
SER C 156
ALA C 174
 None
 1.05A 5msdA-5dwzC:
undetectable		 5msdA-5dwzC:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exk LIPOYL SYNTHASE

(Mycobacterium
tuberculosis) 		PF04055
(Radical_SAM)
PF16881
(LIAS_N) 		4 ILE A 143
PHE A  74
SER A 109
ALA A 118
 None
 1.09A 5msdA-5exkA:
2.9		 5msdA-5exkA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f38 ACETYL-COA
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ILE B 110
PHE B  82
SER B  94
ALA B 101
 None
 1.07A 5msdA-5f38B:
undetectable		 5msdA-5f38B:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbu PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N) 		4 ILE A 679
PHE A 466
SER A 454
ALA A 683
 None
 1.19A 5msdA-5fbuA:
undetectable		 5msdA-5fbuA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt2 PROBABLE
DEFERROCHELATASE/PER
OXIDASE YFEX

(Escherichia
coli) 		PF04261
(Dyp_perox) 		4 ILE A  99
PHE A  45
SER A 109
ALA A 114
 None
 1.21A 5msdA-5gt2A:
undetectable		 5msdA-5gt2A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h11 UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF07393
(Sec10) 		4 HIS A 458
ILE A 459
SER A 412
ALA A 489
 None
 1.20A 5msdA-5h11A:
2.1		 5msdA-5h11A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00180
(Iso_dh) 		4 ILE A 135
PHE A 160
SER A 212
ALA A 140
 None
 1.00A 5msdA-5hn4A:
2.6		 5msdA-5hn4A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA

(Lactobacillus
plantarum) 		PF09861
(DUF2088) 		4 HIS A 133
ILE A 190
SER A 140
ALA A 159
 None
None
SO4  A 512 ( 4.5A)
None
 1.11A 5msdA-5huqA:
undetectable		 5msdA-5huqA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irc RHO
GTPASE-ACTIVATING
PROTEIN 35

(Rattus
norvegicus) 		PF00620
(RhoGAP) 		4 HIS A1378
ILE A1272
PHE A1400
ALA A1318
 None
 1.20A 5msdA-5ircA:
undetectable		 5msdA-5ircA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE

(Arabidopsis
thaliana) 		PF03254
(XG_FTase) 		4 HIS A 523
ILE A 551
PHE A 368
ALA A 480
 None
None
GDP  A 601 (-4.9A)
None
 1.19A 5msdA-5kx6A:
undetectable		 5msdA-5kx6A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II
PROTEIN D1
PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00124
(Photo_RC)
PF00421
(PSII) 		4 ILE A 283
PHE C 435
SER A 148
ALA A 153
 PHO  A 404 (-4.1A)
None
None
CLA  A 402 ( 3.7A)
 1.20A 5msdA-5mdxA:
undetectable		 5msdA-5mdxA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 HIS A 579
ILE A 559
SER A 578
ALA A 390
 None
 1.23A 5msdA-5mkkA:
undetectable		 5msdA-5mkkA:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5msc CARBOXYLIC ACID
REDUCTASE

(Nocardia
iowensis) 		PF00501
(AMP-binding) 		5 HIS A 300
ILE A 301
PHE A 341
SER A 395
ALA A 425
 AMP  A1201 (-4.1A)
None
None
None
None
 0.55A 5msdA-5mscA:
59.0		 5msdA-5mscA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oei UNCHARACTERIZED
PROTEIN FAMILY
UPF0065:TAT PATHWAY
SIGNAL

(Rhodopseudomonas
palustris) 		no annotation 4 ILE A 107
PHE A  48
SER A  82
ALA A  86
 None
OOG  A 401 (-4.0A)
None
None
 1.19A 5msdA-5oeiA:
undetectable		 5msdA-5oeiA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tch TRYPTOPHAN SYNTHASE
BETA CHAIN

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		4 HIS B 256
ILE B 252
PHE B  19
ALA B 205
 None
 1.21A 5msdA-5tchB:
undetectable		 5msdA-5tchB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		4 HIS E 331
ILE E 496
SER E 420
ALA E 427
 None
 1.20A 5msdA-5u8sE:
undetectable		 5msdA-5u8sE:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vg9 PROTEIN-S-ISOPRENYLC
YSTEINE
O-METHYLTRANSFERASE

(Tribolium
castaneum) 		no annotation 4 ILE A  66
PHE A 123
SER A   9
ALA A  63
 None
 1.11A 5msdA-5vg9A:
undetectable		 5msdA-5vg9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		4 HIS A 399
ILE A 402
PHE A 540
ALA A 406
 None
 1.14A 5msdA-5w1uA:
undetectable		 5msdA-5w1uA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqs BETA-AMYLASE

(Ipomoea batatas) 		no annotation 4 ILE A 301
PHE A 201
SER A 359
ALA A 312
 None
IPA  A 501 ( 4.4A)
None
None
 1.16A 5msdA-5wqsA:
2.4		 5msdA-5wqsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Pseudomonas
aeruginosa) 		no annotation 4 ILE B  30
PHE B 108
SER B 112
ALA B  28
 None
 1.20A 5msdA-5wybB:
undetectable		 5msdA-5wybB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
aureus) 		no annotation 4 HIS A 382
ILE A 431
SER A 446
ALA A 453
 None
 0.93A 5msdA-5xexA:
undetectable		 5msdA-5xexA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjg VACUOLAR PROTEIN 8

(Saccharomyces
cerevisiae) 		PF00514
(Arm) 		4 ILE A 418
PHE A 373
SER A 409
ALA A 416
 None
 1.11A 5msdA-5xjgA:
undetectable		 5msdA-5xjgA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
epidermidis) 		no annotation 4 HIS A 382
ILE A 431
SER A 446
ALA A 453
 None
 0.97A 5msdA-5yjjA:
undetectable		 5msdA-5yjjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2

(Candidatus
Methanoperedens
nitroreducens) 		no annotation 4 HIS A 123
ILE A  99
SER A 176
ALA A 102
 None
 1.25A 5msdA-6bxnA:
2.6		 5msdA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ct0 DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 HIS 0 445
ILE 0 443
SER 0 617
ALA 0 585
 None
 1.22A 5msdA-6ct00:
undetectable		 5msdA-6ct00:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 4 HIS K 788
ILE K 506
SER K 510
ALA K 559
 None
 1.22A 5msdA-6d6qK:
2.2		 5msdA-6d6qK:
undetectable