SIMILAR PATTERNS OF AMINO ACIDS FOR 5MO4_A_NILA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  41
LYS A  56
GLU A  74
PHE A 111
MET A 112
 ANP  A 400 (-4.1A)
ANP  A 400 (-2.9A)
None
ANP  A 400 ( 4.3A)
None
 0.69A 5mo4A-1cm8A:
18.7		 5mo4A-1cm8A:
22.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 209
GLU A 236
ILE A 264
MET A 269
GLY A 272
 None
 0.63A 5mo4A-1k9aA:
26.8		 5mo4A-1k9aA:
39.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
TYR A 272
VAL A 275
GLU A 305
ILE A 332
MET A 337
GLY A 340
 P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-4.1A)
None
P16  A   2 (-3.4A)
 0.74A 5mo4A-1opkA:
54.2		 5mo4A-1opkA:
98.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 267
VAL A 275
LYS A 290
GLU A 305
ILE A 332
PHE A 336
MET A 337
GLY A 340
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-4.1A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
 0.58A 5mo4A-1opkA:
54.2		 5mo4A-1opkA:
98.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  78
VAL A  86
ILE A 145
MET A 150
GLY A 153
 ATP  A 535 (-3.9A)
ATP  A 535 (-4.1A)
5EA  A1001 ( 3.7A)
None
ATP  A 535 ( 4.7A)
 0.59A 5mo4A-1s9iA:
5.9		 5mo4A-1s9iA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
VAL A 603
LYS A 623
GLU A 640
GLY A 676
PHE A 811
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 ( 3.8A)
STI  A   3 (-3.6A)
 1.23A 5mo4A-1t46A:
9.0		 5mo4A-1t46A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 344
VAL A 352
LYS A 369
GLU A 386
GLY A 420
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
None
STU  A 100 (-3.5A)
 0.46A 5mo4A-1u59A:
25.4		 5mo4A-1u59A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B 281
LYS B 296
GLU B 308
ILE B 364
PHE B 368
GLY B 372
 None
 0.70A 5mo4A-2a1aB:
18.1		 5mo4A-2a1aB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  26
VAL A  34
LYS A  49
GLU A  65
PHE A 100
GLY A 104
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 ( 4.0A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
 0.66A 5mo4A-2bujA:
19.7		 5mo4A-2bujA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
VAL X  25
GLU X  54
ILE X  80
MET X  85
GLY X  88
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-3.5A)
 0.54A 5mo4A-2dq7X:
26.4		 5mo4A-2dq7X:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
VAL X  25
LYS X  39
GLU X  54
ILE X  80
GLY X  88
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-3.5A)
 0.54A 5mo4A-2dq7X:
26.4		 5mo4A-2dq7X:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 162
VAL A 170
LYS A 186
GLU A 201
ILE A 234
GLY A 240
 None
 0.74A 5mo4A-2eu9A:
7.4		 5mo4A-2eu9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
LYS A  42
GLU A  59
ILE A  91
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
None
None
 0.58A 5mo4A-2f9gA:
18.9		 5mo4A-2f9gA:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
ILE A 336
MET A 341
GLY A 344
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 ( 4.5A)
None
H8H  A 534 (-3.3A)
 0.64A 5mo4A-2h8hA:
38.3		 5mo4A-2h8hA:
40.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
LYS A 295
ILE A 336
PHE A 340
MET A 341
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
QUE  A   1 (-4.2A)
None
 0.84A 5mo4A-2hckA:
37.5		 5mo4A-2hckA:
38.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
GLU A 288
ILE A 314
PHE A 318
MET A 319
GLY A 322
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.9A)
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
 1.05A 5mo4A-2hk5A:
26.8		 5mo4A-2hk5A:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
LYS A 273
GLU A 288
ILE A 314
PHE A 318
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.9A)
1BM  A 499 (-4.1A)
 0.77A 5mo4A-2hk5A:
26.8		 5mo4A-2hk5A:
29.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLU A 286
ILE A 313
PHE A 317
MET A 318
GLY A 321
PHE A 382
 GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-4.3A)
None
None
GIN  A 600 (-4.0A)
 0.87A 5mo4A-2hz0A:
7.5		 5mo4A-2hz0A:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 248
VAL A 256
GLU A 286
ILE A 313
PHE A 317
MET A 318
GLY A 321
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-4.3A)
None
None
 0.51A 5mo4A-2hz0A:
7.5		 5mo4A-2hz0A:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
VAL A 256
LYS A 271
GLU A 286
ILE A 313
PHE A 317
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-4.3A)
 0.67A 5mo4A-2hz0A:
7.5		 5mo4A-2hz0A:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 VAL A 436
LYS A 454
GLU A 471
ILE A 497
GLY A 505
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
 0.30A 5mo4A-2j0jA:
27.0		 5mo4A-2j0jA:
30.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
GLU A 288
ILE A 314
MET A 319
GLY A 322
PHE A 383
 None
None
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.72A 5mo4A-2og8A:
26.3		 5mo4A-2og8A:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		5 LEU A  25
VAL A  33
LYS A  48
MET A 106
GLY A 109
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
 0.61A 5mo4A-2phkA:
16.6		 5mo4A-2phkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		5 VAL A  33
LYS A  48
GLU A  73
MET A 106
GLY A 109
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
None
 0.62A 5mo4A-2phkA:
16.6		 5mo4A-2phkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
LYS A  42
GLU A  64
GLY A  99
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
 0.67A 5mo4A-2w4kA:
20.2		 5mo4A-2w4kA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 635
LYS A 653
ILE A 697
MET A 702
GLY A 705
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
None
Q9G  A1898 ( 3.8A)
 0.52A 5mo4A-2xyuA:
27.9		 5mo4A-2xyuA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
LYS A  42
GLU A  64
GLY A  99
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
None
None
 0.63A 5mo4A-2yabA:
20.3		 5mo4A-2yabA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 313
LYS A 328
GLU A 346
ILE A 374
GLY A 382
 770  A 901 ( 4.7A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
None
770  A 901 (-3.4A)
 0.70A 5mo4A-2z2wA:
16.4		 5mo4A-2z2wA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  68
VAL A  76
LYS A  94
PHE A 143
GLY A 147
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
 0.61A 5mo4A-2z7rA:
16.5		 5mo4A-2z7rA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 253
VAL A 261
ILE A 317
PHE A 321
MET A 322
GLY A 325
 None
 0.95A 5mo4A-2zv7A:
26.5		 5mo4A-2zv7A:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 253
VAL A 261
LYS A 275
GLU A 290
ILE A 317
 None
 0.63A 5mo4A-2zv7A:
26.5		 5mo4A-2zv7A:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  97
VAL A 105
LYS A 123
GLU A 143
GLY A 178
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.4A)
 0.45A 5mo4A-3a62A:
18.0		 5mo4A-3a62A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 484
VAL A 492
LYS A 514
GLU A 531
GLY A 567
PHE A 489
 C4F  A   1 ( 3.9A)
None
None
None
None
C4F  A   1 (-3.7A)
 0.76A 5mo4A-3c4fA:
9.9		 5mo4A-3c4fA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 209
GLU A 236
ILE A 264
MET A 269
GLY A 272
 None
 0.62A 5mo4A-3d7uA:
26.8		 5mo4A-3d7uA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 647
LYS A 665
GLU A 682
ILE A 709
PHE A 713
MET A 714
PHE A 777
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
None
None
None
IHZ  A1001 (-4.7A)
 0.77A 5mo4A-3dkoA:
26.5		 5mo4A-3dkoA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 647
LYS A 665
ILE A 709
PHE A 713
MET A 714
GLY A 717
PHE A 777
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
None
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.7A)
 0.71A 5mo4A-3dkoA:
26.5		 5mo4A-3dkoA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  59
VAL A  67
LYS A  82
ILE A 127
MET A 132
 STU  A   1 (-3.8A)
None
STU  A   1 ( 4.2A)
None
None
 0.40A 5mo4A-3fmeA:
16.9		 5mo4A-3fmeA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 833
VAL A 841
LYS A 861
GLU A 878
GLY A 915
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
 0.57A 5mo4A-3hngA:
25.9		 5mo4A-3hngA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		5 LEU A 226
VAL A 234
ILE A 299
MET A 304
GLY A 307
 None
 0.66A 5mo4A-3i6uA:
17.9		 5mo4A-3i6uA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 LEU A 680
VAL A 689
LYS A 702
GLU A 715
ILE A 743
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
ADP  A2101 (-2.7A)
None
None
 0.62A 5mo4A-3lj0A:
18.3		 5mo4A-3lj0A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  49
VAL A  57
LYS A  72
GLU A  91
GLY A 126
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
None
None
None
 0.58A 5mo4A-3mvjA:
undetectable		 5mo4A-3mvjA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 726
VAL A 734
LYS A 753
MET A 801
GLY A 804
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-4.7A)
None
03Q  A   1 ( 3.9A)
 0.64A 5mo4A-3pp0A:
9.7		 5mo4A-3pp0A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  63
VAL A  71
LYS A  86
GLU A 115
PHE A 146
GLY A 150
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.8A)
None
 0.93A 5mo4A-3q5iA:
17.1		 5mo4A-3q5iA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  50
VAL A  58
LYS A  73
GLU A  84
ILE A 116
GLY A 124
 I85  A 350 (-3.7A)
I85  A 350 (-4.9A)
I85  A 350 (-2.8A)
None
None
I85  A 350 (-3.0A)
 0.86A 5mo4A-3sheA:
16.0		 5mo4A-3sheA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 484
VAL A 492
LYS A 514
GLU A 531
GLY A 567
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
 0.47A 5mo4A-3tt0A:
26.4		 5mo4A-3tt0A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 361
VAL A 369
LYS A 384
GLU A 403
PHE A 435
GLY A 439
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
None
 0.74A 5mo4A-3txoA:
14.0		 5mo4A-3txoA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 544
VAL A 552
LYS A 572
MET A 620
GLY A 623
PHE A 698
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.0A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.1A)
 1.05A 5mo4A-3v5qA:
14.3		 5mo4A-3v5qA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
LYS A 868
GLU A 885
PHE A 918
GLY A 922
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
 0.54A 5mo4A-3vidA:
8.5		 5mo4A-3vidA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  75
VAL A  83
ILE A 142
MET A 147
GLY A 150
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
CHU  A 403 (-3.8A)
None
ANP  A 401 ( 4.3A)
 0.70A 5mo4A-3wigA:
18.8		 5mo4A-3wigA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  75
VAL A  83
LYS A  98
ILE A 142
GLY A 149
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
None
 0.67A 5mo4A-3wigA:
18.8		 5mo4A-3wigA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
LYS A 868
GLU A 885
PHE A 918
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
LEV  A1201 (-3.7A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
 0.63A 5mo4A-3wzdA:
undetectable		 5mo4A-3wzdA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
GLU A 885
PHE A 918
GLY A 922
PHE A1047
 B49  A2000 (-3.7A)
None
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.0A)
 1.03A 5mo4A-4agdA:
9.2		 5mo4A-4agdA:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 560
VAL A 568
LYS A 588
MET A 636
GLY A 639
 LTI  A1839 ( 4.2A)
None
None
None
LTI  A1839 (-3.4A)
 0.52A 5mo4A-4at3A:
26.6		 5mo4A-4at3A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 105
ILE A 167
PHE A 171
MET A 172
GLY A 175
 30K  A1365 ( 4.6A)
None
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
 0.65A 5mo4A-4aw5A:
25.0		 5mo4A-4aw5A:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  42
VAL A  50
GLU A  81
ILE A 108
PHE A 112
GLY A 116
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
 0.84A 5mo4A-4bc6A:
14.0		 5mo4A-4bc6A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  42
VAL A  50
LYS A  65
ILE A 108
PHE A 112
GLY A 116
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
 0.71A 5mo4A-4bc6A:
14.0		 5mo4A-4bc6A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		5 LEU A 246
VAL A 254
LYS A 269
GLU A 288
GLY A 324
 None
 0.56A 5mo4A-4c0tA:
15.8		 5mo4A-4c0tA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
LYS A 655
GLU A 672
MET A 704
GLY A 707
PHE A 785
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
None
None
DI1  A1000 (-4.5A)
 0.80A 5mo4A-4ckrA:
11.1		 5mo4A-4ckrA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 663
VAL A 671
LYS A 686
GLU A 705
GLY A 743
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
None
 0.68A 5mo4A-4crsA:
16.1		 5mo4A-4crsA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
LYS A  38
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.63A 5mo4A-4eutA:
16.3		 5mo4A-4eutA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
LYS A  38
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
 0.52A 5mo4A-4euuA:
15.7		 5mo4A-4euuA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1122
VAL A1130
GLU A1167
ILE A1194
MET A1199
GLY A1201
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
None
None
None
0UV  A1501 (-4.4A)
 1.12A 5mo4A-4fodA:
10.2		 5mo4A-4fodA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1122
VAL A1130
GLU A1167
ILE A1194
MET A1199
GLY A1202
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
None
None
None
0UV  A1501 (-3.6A)
 0.86A 5mo4A-4fodA:
10.2		 5mo4A-4fodA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1122
VAL A1130
LYS A1150
GLU A1167
ILE A1194
GLY A1201
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.7A)
None
None
0UV  A1501 (-4.4A)
 1.18A 5mo4A-4fodA:
10.2		 5mo4A-4fodA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 VAL A 416
LYS A 431
GLU A 442
ILE A 469
GLY A 477
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
0WB  A 701 (-3.9A)
0WB  A 701 ( 4.5A)
 0.43A 5mo4A-4g3fA:
18.7		 5mo4A-4g3fA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 855
VAL A 863
LYS A 882
GLU A 898
GLY A 935
 IZA  A2001 (-3.7A)
None
IZA  A2001 ( 4.7A)
None
IZA  A2001 (-3.3A)
 0.69A 5mo4A-4gl9A:
23.6		 5mo4A-4gl9A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 156
VAL A 164
LYS A 179
GLU A 198
GLY A 233
 0XZ  A 501 ( 4.1A)
0XZ  A 501 (-4.5A)
GOL  A 503 ( 2.8A)
GOL  A 503 (-3.6A)
None
 0.61A 5mo4A-4gv1A:
18.2		 5mo4A-4gv1A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 828
VAL A 836
LYS A 855
GLU A 871
GLY A 908
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.5A)
None
19S  A1201 ( 3.8A)
 0.53A 5mo4A-4hviA:
23.9		 5mo4A-4hviA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 406
VAL A 414
LYS A 429
GLU A 440
ILE A 467
GLY A 475
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
None
T28  A 701 ( 3.0A)
 0.92A 5mo4A-4idtA:
18.9		 5mo4A-4idtA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU A  15
VAL A  23
LYS A  38
PHE A  88
GLY A  92
 SU6  A 701 (-3.6A)
None
None
SU6  A 701 (-4.0A)
SU6  A 701 (-3.8A)
 0.62A 5mo4A-4jlcA:
13.3		 5mo4A-4jlcA:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
LYS A 295
GLU A 310
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 (-4.2A)
 0.66A 5mo4A-4lggA:
25.5		 5mo4A-4lggA:
37.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL B  38
LYS B  53
GLU B  70
ILE B  97
GLY B 103
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.1A)
None
None
None
 0.57A 5mo4A-4o27B:
17.5		 5mo4A-4o27B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 903
VAL A 911
LYS A 930
GLU A 947
GLY A 984
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
2TT  A1202 (-3.4A)
 0.63A 5mo4A-4oliA:
23.0		 5mo4A-4oliA:
27.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		5 LEU A  14
VAL A  22
ILE A  79
MET A  84
GLY A  87
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
ACP  A1264 (-3.5A)
 0.63A 5mo4A-4ueuA:
9.4		 5mo4A-4ueuA:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		5 LEU A  14
VAL A  22
LYS A  37
GLU A  52
ILE A  79
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
 0.58A 5mo4A-4ueuA:
9.4		 5mo4A-4ueuA:
37.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		5 LEU A 104
VAL A 112
LYS A 127
GLU A 146
GLY A 181
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
None
 0.63A 5mo4A-4wb7A:
18.3		 5mo4A-4wb7A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  52
VAL A  60
LYS A  74
ILE A 124
PHE A 128
GLY A 132
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
 0.69A 5mo4A-4wsqA:
19.0		 5mo4A-4wsqA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  60
LYS A  74
GLU A  90
ILE A 124
PHE A 128
GLY A 132
 KSA  A 405 ( 4.9A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
 0.82A 5mo4A-4wsqA:
19.0		 5mo4A-4wsqA:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
VAL B 275
ILE B 332
PHE B 336
MET B 337
GLY B 340
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-4.1A)
1N1  B 601 ( 4.2A)
None
1N1  B 601 (-3.5A)
 0.78A 5mo4A-4xeyB:
28.4		 5mo4A-4xeyB:
80.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
VAL A 624
LYS A 644
GLU A 661
GLY A 697
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.1A)
 0.83A 5mo4A-4xufA:
11.6		 5mo4A-4xufA:
26.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 LEU A 408
VAL A 416
ILE A 472
MET A 477
GLY A 480
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
None
None
746  A 702 (-3.6A)
 0.47A 5mo4A-4y93A:
26.6		 5mo4A-4y93A:
34.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 477
LYS A 490
GLU A 509
ILE A 537
GLY A 545
 None
4CV  A 801 (-3.9A)
None
None
4CV  A 801 ( 4.0A)
 0.60A 5mo4A-4yffA:
20.8		 5mo4A-4yffA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LEU A  34
VAL A  42
LYS A  57
GLU A  76
GLY A 111
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
None
None
 0.70A 5mo4A-4ysjA:
19.0		 5mo4A-4ysjA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
VAL A 607
LYS A 627
GLU A 644
ILE A 672
GLY A 680
PHE A 837
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 ( 4.0A)
748  A1001 (-3.7A)
 1.08A 5mo4A-5grnA:
23.0		 5mo4A-5grnA:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  57
VAL A  65
LYS A  79
ILE A 128
GLY A 136
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
 0.62A 5mo4A-5i3oA:
18.9		 5mo4A-5i3oA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
LYS A  45
GLU A  61
ILE A  88
PHE A  92
GLY A  96
 6G2  A 901 ( 4.9A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
 0.61A 5mo4A-5j5tA:
12.5		 5mo4A-5j5tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 647
LYS A 665
ILE A 709
PHE A 713
MET A 714
 None
None
6P6  A1001 ( 4.5A)
6P6  A1001 ( 4.5A)
None
 0.61A 5mo4A-5l6oA:
26.9		 5mo4A-5l6oA:
25.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 542
VAL A 550
PHE A 622
MET A 623
GLY A 626
 7YS  A9001 (-4.1A)
7YS  A9001 (-4.2A)
7YS  A9001 (-4.3A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
 0.58A 5mo4A-5u6bA:
25.8		 5mo4A-5u6bA:
30.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 6 LEU A  17
VAL A  25
LYS A  40
GLU A  59
ILE A  90
GLY A  97
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-3.2A)
G93  A 301 ( 3.8A)
GOL  A 305 ( 4.3A)
 0.72A 5mo4A-5u94A:
18.3		 5mo4A-5u94A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 6 LEU A 686
VAL A 694
LYS A 709
GLU A 725
ILE A 752
GLY A 760
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-2.8A)
None
None
9E1  A1001 (-3.4A)
 0.67A 5mo4A-5vilA:
18.4		 5mo4A-5vilA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 5 LEU A  24
VAL A  32
ILE A  93
MET A  98
GLY A 101
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.9A)
None
9WS  A 401 ( 4.3A)
 0.56A 5mo4A-5w5jA:
8.3		 5mo4A-5w5jA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 5 LEU A 891
VAL A 899
LYS A 919
ILE A 961
GLY A 969
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
None
ANP  A1201 ( 4.6A)
 0.63A 5mo4A-5wnoA:
5.4		 5mo4A-5wnoA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 5 LEU A 366
VAL A 374
LYS A 390
GLU A 409
GLY A 444
 EE4  A 701 ( 4.6A)
EE4  A 701 (-4.4A)
DMS  A 702 (-3.5A)
DMS  A 702 ( 4.2A)
None
 0.57A 5mo4A-6c0tA:
16.5		 5mo4A-6c0tA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 LEU A 881
VAL A 889
GLU A 925
PHE A 958
GLY A 962
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
None
None
ADP  A1201 ( 4.1A)
 0.64A 5mo4A-6c7yA:
23.7		 5mo4A-6c7yA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 LEU A 881
VAL A 889
LYS A 908
GLU A 925
PHE A 958
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-2.8A)
None
None
 0.40A 5mo4A-6c7yA:
23.7		 5mo4A-6c7yA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 LEU A 197
VAL A 205
ILE A 262
MET A 267
GLY A 270
PHE A 331
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
None
FKY  A9001 (-3.3A)
FKY  A9001 (-3.9A)
 1.04A 5mo4A-6cz4A:
21.1		 5mo4A-6cz4A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 LEU A 197
VAL A 205
LYS A 219
ILE A 262
MET A 267
PHE A 331
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
None
None
FKY  A9001 (-3.9A)
 0.99A 5mo4A-6cz4A:
21.1		 5mo4A-6cz4A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 LEU A 169
VAL A 177
LYS A 193
GLU A 208
ILE A 241
GLY A 247
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
None
None
 0.67A 5mo4A-6fylA:
19.0		 5mo4A-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 5 LEU A 167
VAL A 175
LYS A 191
GLU A 206
ILE A 239
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
 0.42A 5mo4A-6fyoA:
18.8		 5mo4A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 6 LEU A 167
VAL A 175
LYS A 191
GLU A 206
ILE A 239
GLY A 245
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
 0.67A 5mo4A-6fyvA:
9.7		 5mo4A-6fyvA:
undetectable