SIMILAR PATTERNS OF AMINO ACIDS FOR 5MO4_A_NILA601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  41
LYS A  56
GLU A  74
PHE A 111
MET A 112
 ANP  A 400 (-4.1A)
ANP  A 400 (-2.9A)
None
ANP  A 400 ( 4.3A)
None
 0.69A 5mo4A-1cm8A:
18.7		 5mo4A-1cm8A:
22.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 209
GLU A 236
ILE A 264
MET A 269
GLY A 272
 None
 0.63A 5mo4A-1k9aA:
26.8		 5mo4A-1k9aA:
39.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
TYR A 272
VAL A 275
GLU A 305
ILE A 332
MET A 337
GLY A 340
 P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-4.1A)
None
P16  A   2 (-3.4A)
 0.74A 5mo4A-1opkA:
54.2		 5mo4A-1opkA:
98.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 267
VAL A 275
LYS A 290
GLU A 305
ILE A 332
PHE A 336
MET A 337
GLY A 340
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-4.1A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
 0.58A 5mo4A-1opkA:
54.2		 5mo4A-1opkA:
98.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  78
VAL A  86
ILE A 145
MET A 150
GLY A 153
 ATP  A 535 (-3.9A)
ATP  A 535 (-4.1A)
5EA  A1001 ( 3.7A)
None
ATP  A 535 ( 4.7A)
 0.59A 5mo4A-1s9iA:
5.9		 5mo4A-1s9iA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
VAL A 603
LYS A 623
GLU A 640
GLY A 676
PHE A 811
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 ( 3.8A)
STI  A   3 (-3.6A)
 1.23A 5mo4A-1t46A:
9.0		 5mo4A-1t46A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 344
VAL A 352
LYS A 369
GLU A 386
GLY A 420
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
None
STU  A 100 (-3.5A)
 0.46A 5mo4A-1u59A:
25.4		 5mo4A-1u59A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B 281
LYS B 296
GLU B 308
ILE B 364
PHE B 368
GLY B 372
 None
 0.70A 5mo4A-2a1aB:
18.1		 5mo4A-2a1aB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  26
VAL A  34
LYS A  49
GLU A  65
PHE A 100
GLY A 104
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 ( 4.0A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
 0.66A 5mo4A-2bujA:
19.7		 5mo4A-2bujA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
VAL X  25
GLU X  54
ILE X  80
MET X  85
GLY X  88
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-3.5A)
 0.54A 5mo4A-2dq7X:
26.4		 5mo4A-2dq7X:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
VAL X  25
LYS X  39
GLU X  54
ILE X  80
GLY X  88
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-3.5A)
 0.54A 5mo4A-2dq7X:
26.4		 5mo4A-2dq7X:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 162
VAL A 170
LYS A 186
GLU A 201
ILE A 234
GLY A 240
 None
 0.74A 5mo4A-2eu9A:
7.4		 5mo4A-2eu9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
LYS A  42
GLU A  59
ILE A  91
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
None
None
 0.58A 5mo4A-2f9gA:
18.9		 5mo4A-2f9gA:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
ILE A 336
MET A 341
GLY A 344
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 ( 4.5A)
None
H8H  A 534 (-3.3A)
 0.64A 5mo4A-2h8hA:
38.3		 5mo4A-2h8hA:
40.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
LYS A 295
ILE A 336
PHE A 340
MET A 341
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
QUE  A   1 (-4.2A)
None
 0.84A 5mo4A-2hckA:
37.5		 5mo4A-2hckA:
38.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
GLU A 288
ILE A 314
PHE A 318
MET A 319
GLY A 322
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.9A)
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
 1.05A 5mo4A-2hk5A:
26.8		 5mo4A-2hk5A:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
LYS A 273
GLU A 288
ILE A 314
PHE A 318
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.9A)
1BM  A 499 (-4.1A)
 0.77A 5mo4A-2hk5A:
26.8		 5mo4A-2hk5A:
29.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLU A 286
ILE A 313
PHE A 317
MET A 318
GLY A 321
PHE A 382
 GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-4.3A)
None
None
GIN  A 600 (-4.0A)
 0.87A 5mo4A-2hz0A:
7.5		 5mo4A-2hz0A:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 248
VAL A 256
GLU A 286
ILE A 313
PHE A 317
MET A 318
GLY A 321
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-4.3A)
None
None
 0.51A 5mo4A-2hz0A:
7.5		 5mo4A-2hz0A:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
VAL A 256
LYS A 271
GLU A 286
ILE A 313
PHE A 317
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-4.3A)
 0.67A 5mo4A-2hz0A:
7.5		 5mo4A-2hz0A:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 VAL A 436
LYS A 454
GLU A 471
ILE A 497
GLY A 505
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
 0.30A 5mo4A-2j0jA:
27.0		 5mo4A-2j0jA:
30.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
GLU A 288
ILE A 314
MET A 319
GLY A 322
PHE A 383
 None
None
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.72A 5mo4A-2og8A:
26.3		 5mo4A-2og8A:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		5 LEU A  25
VAL A  33
LYS A  48
MET A 106
GLY A 109
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
 0.61A 5mo4A-2phkA:
16.6		 5mo4A-2phkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		5 VAL A  33
LYS A  48
GLU A  73
MET A 106
GLY A 109
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
None
 0.62A 5mo4A-2phkA:
16.6		 5mo4A-2phkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
LYS A  42
GLU A  64
GLY A  99
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
 0.67A 5mo4A-2w4kA:
20.2		 5mo4A-2w4kA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 635
LYS A 653
ILE A 697
MET A 702
GLY A 705
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
None
Q9G  A1898 ( 3.8A)
 0.52A 5mo4A-2xyuA:
27.9		 5mo4A-2xyuA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
LYS A  42
GLU A  64
GLY A  99
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
None
None
 0.63A 5mo4A-2yabA:
20.3		 5mo4A-2yabA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 313
LYS A 328
GLU A 346
ILE A 374
GLY A 382
 770  A 901 ( 4.7A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
None
770  A 901 (-3.4A)
 0.70A 5mo4A-2z2wA:
16.4		 5mo4A-2z2wA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  68
VAL A  76
LYS A  94
PHE A 143
GLY A 147
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
 0.61A 5mo4A-2z7rA:
16.5		 5mo4A-2z7rA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 253
VAL A 261
ILE A 317
PHE A 321
MET A 322
GLY A 325
 None
 0.95A 5mo4A-2zv7A:
26.5		 5mo4A-2zv7A:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 253
VAL A 261
LYS A 275
GLU A 290
ILE A 317
 None
 0.63A 5mo4A-2zv7A:
26.5		 5mo4A-2zv7A:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  97
VAL A 105
LYS A 123
GLU A 143
GLY A 178
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.4A)
 0.45A 5mo4A-3a62A:
18.0		 5mo4A-3a62A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 484
VAL A 492
LYS A 514
GLU A 531
GLY A 567
PHE A 489
 C4F  A   1 ( 3.9A)
None
None
None
None
C4F  A   1 (-3.7A)
 0.76A 5mo4A-3c4fA:
9.9		 5mo4A-3c4fA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 209
GLU A 236
ILE A 264
MET A 269
GLY A 272
 None
 0.62A 5mo4A-3d7uA:
26.8		 5mo4A-3d7uA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 647
LYS A 665
GLU A 682
ILE A 709
PHE A 713
MET A 714
PHE A 777
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
None
None
None
IHZ  A1001 (-4.7A)
 0.77A 5mo4A-3dkoA:
26.5		 5mo4A-3dkoA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 647
LYS A 665
ILE A 709
PHE A 713
MET A 714
GLY A 717
PHE A 777
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
None
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.7A)
 0.71A 5mo4A-3dkoA:
26.5		 5mo4A-3dkoA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  59
VAL A  67
LYS A  82
ILE A 127
MET A 132
 STU  A   1 (-3.8A)
None
STU  A   1 ( 4.2A)
None
None
 0.40A 5mo4A-3fmeA:
16.9		 5mo4A-3fmeA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 833
VAL A 841
LYS A 861
GLU A 878
GLY A 915
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
 0.57A 5mo4A-3hngA:
25.9		 5mo4A-3hngA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		5 LEU A 226
VAL A 234
ILE A 299
MET A 304
GLY A 307
 None
 0.66A 5mo4A-3i6uA:
17.9		 5mo4A-3i6uA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 LEU A 680
VAL A 689
LYS A 702
GLU A 715
ILE A 743
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
ADP  A2101 (-2.7A)
None
None
 0.62A 5mo4A-3lj0A:
18.3		 5mo4A-3lj0A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  49
VAL A  57
LYS A  72
GLU A  91
GLY A 126
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
None
None
None
 0.58A 5mo4A-3mvjA:
undetectable		 5mo4A-3mvjA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 726
VAL A 734
LYS A 753
MET A 801
GLY A 804
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-4.7A)
None
03Q  A   1 ( 3.9A)
 0.64A 5mo4A-3pp0A:
9.7		 5mo4A-3pp0A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  63
VAL A  71
LYS A  86
GLU A 115
PHE A 146
GLY A 150
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.8A)
None
 0.93A 5mo4A-3q5iA:
17.1		 5mo4A-3q5iA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  50
VAL A  58
LYS A  73
GLU A  84
ILE A 116
GLY A 124
 I85  A 350 (-3.7A)
I85  A 350 (-4.9A)
I85  A 350 (-2.8A)
None
None
I85  A 350 (-3.0A)
 0.86A 5mo4A-3sheA:
16.0		 5mo4A-3sheA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 484
VAL A 492
LYS A 514
GLU A 531
GLY A 567
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
 0.47A 5mo4A-3tt0A:
26.4		 5mo4A-3tt0A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 361
VAL A 369
LYS A 384
GLU A 403
PHE A 435
GLY A 439
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
None
 0.74A 5mo4A-3txoA:
14.0		 5mo4A-3txoA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 544
VAL A 552
LYS A 572
MET A 620
GLY A 623
PHE A 698
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.0A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.1A)
 1.05A 5mo4A-3v5qA:
14.3		 5mo4A-3v5qA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
LYS A 868
GLU A 885
PHE A 918
GLY A 922
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
 0.54A 5mo4A-3vidA:
8.5		 5mo4A-3vidA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  75
VAL A  83
ILE A 142
MET A 147
GLY A 150
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
CHU  A 403 (-3.8A)
None
ANP  A 401 ( 4.3A)
 0.70A 5mo4A-3wigA:
18.8		 5mo4A-3wigA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  75
VAL A  83
LYS A  98
ILE A 142
GLY A 149
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
None
 0.67A 5mo4A-3wigA:
18.8		 5mo4A-3wigA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
LYS A 868
GLU A 885
PHE A 918
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
LEV  A1201 (-3.7A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
 0.63A 5mo4A-3wzdA:
undetectable		 5mo4A-3wzdA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
GLU A 885
PHE A 918
GLY A 922
PHE A1047
 B49  A2000 (-3.7A)
None
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.0A)
 1.03A 5mo4A-4agdA:
9.2		 5mo4A-4agdA:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 560
VAL A 568
LYS A 588
MET A 636
GLY A 639
 LTI  A1839 ( 4.2A)
None
None
None
LTI  A1839 (-3.4A)
 0.52A 5mo4A-4at3A:
26.6		 5mo4A-4at3A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 105
ILE A 167
PHE A 171
MET A 172
GLY A 175
 30K  A1365 ( 4.6A)
None
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
 0.65A 5mo4A-4aw5A:
25.0		 5mo4A-4aw5A:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  42
VAL A  50
GLU A  81
ILE A 108
PHE A 112
GLY A 116
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
 0.84A 5mo4A-4bc6A:
14.0		 5mo4A-4bc6A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  42
VAL A  50
LYS A  65
ILE A 108
PHE A 112
GLY A 116
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
 0.71A 5mo4A-4bc6A:
14.0		 5mo4A-4bc6A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		5 LEU A 246
VAL A 254
LYS A 269
GLU A 288
GLY A 324
 None
 0.56A 5mo4A-4c0tA:
15.8		 5mo4A-4c0tA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
LYS A 655
GLU A 672
MET A 704
GLY A 707
PHE A 785
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
None
None
DI1  A1000 (-4.5A)
 0.80A 5mo4A-4ckrA:
11.1		 5mo4A-4ckrA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 663
VAL A 671
LYS A 686
GLU A 705
GLY A 743
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
None
 0.68A 5mo4A-4crsA:
16.1		 5mo4A-4crsA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
LYS A  38
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.63A 5mo4A-4eutA:
16.3		 5mo4A-4eutA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
LYS A  38
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
 0.52A 5mo4A-4euuA:
15.7		 5mo4A-4euuA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1122
VAL A1130
GLU A1167
ILE A1194
MET A1199
GLY A1201
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
None
None
None
0UV  A1501 (-4.4A)
 1.12A 5mo4A-4fodA:
10.2		 5mo4A-4fodA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1122
VAL A1130
GLU A1167
ILE A1194
MET A1199
GLY A1202
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
None
None
None
0UV  A1501 (-3.6A)
 0.86A 5mo4A-4fodA:
10.2		 5mo4A-4fodA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1122
VAL A1130
LYS A1150
GLU A1167
ILE A1194
GLY A1201
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.7A)
None
None
0UV  A1501 (-4.4A)
 1.18A 5mo4A-4fodA:
10.2		 5mo4A-4fodA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 VAL A 416
LYS A 431
GLU A 442
ILE A 469
GLY A 477
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
0WB  A 701 (-3.9A)
0WB  A 701 ( 4.5A)
 0.43A 5mo4A-4g3fA:
18.7		 5mo4A-4g3fA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 855
VAL A 863
LYS A 882
GLU A 898
GLY A 935
 IZA  A2001 (-3.7A)
None
IZA  A2001 ( 4.7A)
None
IZA  A2001 (-3.3A)
 0.69A 5mo4A-4gl9A:
23.6		 5mo4A-4gl9A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 156
VAL A 164
LYS A 179
GLU A 198
GLY A 233
 0XZ  A 501 ( 4.1A)
0XZ  A 501 (-4.5A)
GOL  A 503 ( 2.8A)
GOL  A 503 (-3.6A)
None
 0.61A 5mo4A-4gv1A:
18.2		 5mo4A-4gv1A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 828
VAL A 836
LYS A 855
GLU A 871
GLY A 908
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.5A)
None
19S  A1201 ( 3.8A)
 0.53A 5mo4A-4hviA:
23.9		 5mo4A-4hviA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 406
VAL A 414
LYS A 429
GLU A 440
ILE A 467
GLY A 475
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
None
T28  A 701 ( 3.0A)
 0.92A 5mo4A-4idtA:
18.9		 5mo4A-4idtA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU A  15
VAL A  23
LYS A  38
PHE A  88
GLY A  92
 SU6  A 701 (-3.6A)
None
None
SU6  A 701 (-4.0A)
SU6  A 701 (-3.8A)
 0.62A 5mo4A-4jlcA:
13.3		 5mo4A-4jlcA:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
LYS A 295
GLU A 310
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 (-4.2A)
 0.66A 5mo4A-4lggA:
25.5		 5mo4A-4lggA:
37.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL B  38
LYS B  53
GLU B  70
ILE B  97
GLY B 103
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.1A)
None
None
None
 0.57A 5mo4A-4o27B:
17.5		 5mo4A-4o27B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 903
VAL A 911
LYS A 930
GLU A 947
GLY A 984
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
2TT  A1202 (-3.4A)
 0.63A 5mo4A-4oliA:
23.0		 5mo4A-4oliA:
27.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		5 LEU A  14
VAL A  22
ILE A  79
MET A  84
GLY A  87
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
ACP  A1264 (-3.5A)
 0.63A 5mo4A-4ueuA:
9.4		 5mo4A-4ueuA:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		5 LEU A  14
VAL A  22
LYS A  37
GLU A  52
ILE A  79
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
 0.58A 5mo4A-4ueuA:
9.4		 5mo4A-4ueuA:
37.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		5 LEU A 104
VAL A 112
LYS A 127
GLU A 146
GLY A 181
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
None
 0.63A 5mo4A-4wb7A:
18.3		 5mo4A-4wb7A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  52
VAL A  60
LYS A  74
ILE A 124
PHE A 128
GLY A 132
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
 0.69A 5mo4A-4wsqA:
19.0		 5mo4A-4wsqA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  60
LYS A  74
GLU A  90
ILE A 124
PHE A 128
GLY A 132
 KSA  A 405 ( 4.9A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
 0.82A 5mo4A-4wsqA:
19.0		 5mo4A-4wsqA:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
VAL B 275
ILE B 332
PHE B 336
MET B 337
GLY B 340
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-4.1A)
1N1  B 601 ( 4.2A)
None
1N1  B 601 (-3.5A)
 0.78A 5mo4A-4xeyB:
28.4		 5mo4A-4xeyB:
80.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
VAL A 624
LYS A 644
GLU A 661
GLY A 697
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.1A)
 0.83A 5mo4A-4xufA:
11.6		 5mo4A-4xufA:
26.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 LEU A 408
VAL A 416
ILE A 472
MET A 477
GLY A 480
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
None
None
746  A 702 (-3.6A)
 0.47A 5mo4A-4y93A:
26.6		 5mo4A-4y93A:
34.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 477
LYS A 490
GLU A 509
ILE A 537
GLY A 545
 None
4CV  A 801 (-3.9A)
None
None
4CV  A 801 ( 4.0A)
 0.60A 5mo4A-4yffA:
20.8		 5mo4A-4yffA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LEU A  34
VAL A  42
LYS A  57
GLU A  76
GLY A 111
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
None
None
 0.70A 5mo4A-4ysjA:
19.0		 5mo4A-4ysjA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
VAL A 607
LYS A 627
GLU A 644
ILE A 672
GLY A 680
PHE A 837
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 ( 4.0A)
748  A1001 (-3.7A)
 1.08A 5mo4A-5grnA:
23.0		 5mo4A-5grnA:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  57
VAL A  65
LYS A  79
ILE A 128
GLY A 136
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
 0.62A 5mo4A-5i3oA:
18.9		 5mo4A-5i3oA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
LYS A  45
GLU A  61
ILE A  88
PHE A  92
GLY A  96
 6G2  A 901 ( 4.9A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
 0.61A 5mo4A-5j5tA:
12.5		 5mo4A-5j5tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 647
LYS A 665
ILE A 709
PHE A 713
MET A 714
 None
None
6P6  A1001 ( 4.5A)
6P6  A1001 ( 4.5A)
None
 0.61A 5mo4A-5l6oA:
26.9		 5mo4A-5l6oA:
25.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 542
VAL A 550
PHE A 622
MET A 623
GLY A 626
 7YS  A9001 (-4.1A)
7YS  A9001 (-4.2A)
7YS  A9001 (-4.3A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
 0.58A 5mo4A-5u6bA:
25.8		 5mo4A-5u6bA:
30.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 6 LEU A  17
VAL A  25
LYS A  40
GLU A  59
ILE A  90
GLY A  97
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-3.2A)
G93  A 301 ( 3.8A)
GOL  A 305 ( 4.3A)
 0.72A 5mo4A-5u94A:
18.3		 5mo4A-5u94A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 6 LEU A 686
VAL A 694
LYS A 709
GLU A 725
ILE A 752
GLY A 760
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-2.8A)
None
None
9E1  A1001 (-3.4A)
 0.67A 5mo4A-5vilA:
18.4		 5mo4A-5vilA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 5 LEU A  24
VAL A  32
ILE A  93
MET A  98
GLY A 101
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.9A)
None
9WS  A 401 ( 4.3A)
 0.56A 5mo4A-5w5jA:
8.3		 5mo4A-5w5jA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 5 LEU A 891
VAL A 899
LYS A 919
ILE A 961
GLY A 969
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
None
ANP  A1201 ( 4.6A)
 0.63A 5mo4A-5wnoA:
5.4		 5mo4A-5wnoA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 5 LEU A 366
VAL A 374
LYS A 390
GLU A 409
GLY A 444
 EE4  A 701 ( 4.6A)
EE4  A 701 (-4.4A)
DMS  A 702 (-3.5A)
DMS  A 702 ( 4.2A)
None
 0.57A 5mo4A-6c0tA:
16.5		 5mo4A-6c0tA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 LEU A 881
VAL A 889
GLU A 925
PHE A 958
GLY A 962
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
None
None
ADP  A1201 ( 4.1A)
 0.64A 5mo4A-6c7yA:
23.7		 5mo4A-6c7yA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 LEU A 881
VAL A 889
LYS A 908
GLU A 925
PHE A 958
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-2.8A)
None
None
 0.40A 5mo4A-6c7yA:
23.7		 5mo4A-6c7yA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 LEU A 197
VAL A 205
ILE A 262
MET A 267
GLY A 270
PHE A 331
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
None
FKY  A9001 (-3.3A)
FKY  A9001 (-3.9A)
 1.04A 5mo4A-6cz4A:
21.1		 5mo4A-6cz4A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 LEU A 197
VAL A 205
LYS A 219
ILE A 262
MET A 267
PHE A 331
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
None
None
FKY  A9001 (-3.9A)
 0.99A 5mo4A-6cz4A:
21.1		 5mo4A-6cz4A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 LEU A 169
VAL A 177
LYS A 193
GLU A 208
ILE A 241
GLY A 247
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
None
None
 0.67A 5mo4A-6fylA:
19.0		 5mo4A-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 5 LEU A 167
VAL A 175
LYS A 191
GLU A 206
ILE A 239
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
 0.42A 5mo4A-6fyoA:
18.8		 5mo4A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 6 LEU A 167
VAL A 175
LYS A 191
GLU A 206
ILE A 239
GLY A 245
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
 0.67A 5mo4A-6fyvA:
9.7		 5mo4A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
VAL A  64
HIS A 124
LEU A 133
ALA A 143
 None
 0.50A 5mo4A-1h4lA:
16.4		 5mo4A-1h4lA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 428
LEU A 457
VAL A 458
PHE A 517
HIS A 519
LEU A 528
 None
 0.62A 5mo4A-1k2pA:
24.8		 5mo4A-1k2pA:
28.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
MET A 240
LEU A 248
VAL A 249
HIS A 312
LEU A 321
 None
 0.69A 5mo4A-1k9aA:
26.8		 5mo4A-1k9aA:
39.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
VAL A 239
MET A 240
VAL A 249
HIS A 312
LEU A 321
 None
 0.65A 5mo4A-1k9aA:
26.8		 5mo4A-1k9aA:
39.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 606
VAL A 638
PHE A 720
HIS A 722
LEU A 731
ALA A 741
 None
 0.71A 5mo4A-1lufA:
12.0		 5mo4A-1lufA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 638
PHE A 720
HIS A 722
ALA A 741
ASP A 742
 None
 0.65A 5mo4A-1lufA:
12.0		 5mo4A-1lufA:
29.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 288
VAL A 308
MET A 309
ILE A 312
LEU A 317
HIS A 380
LEU A 389
 P16  A   2 (-3.4A)
None
P16  A   2 (-3.3A)
None
None
None
P16  A   2 (-4.4A)
 0.62A 5mo4A-1opkA:
54.2		 5mo4A-1opkA:
98.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 288
VAL A 308
MET A 309
LEU A 317
HIS A 380
LEU A 389
ALA A 399
 P16  A   2 (-3.4A)
None
P16  A   2 (-3.3A)
None
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.59A 5mo4A-1opkA:
54.2		 5mo4A-1opkA:
98.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 288
VAL A 308
MET A 309
LEU A 317
VAL A 318
HIS A 380
LEU A 389
 P16  A   2 (-3.4A)
None
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
None
P16  A   2 (-4.4A)
 0.58A 5mo4A-1opkA:
54.2		 5mo4A-1opkA:
98.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 389
LEU A 418
VAL A 419
HIS A 480
LEU A 489
 None
 0.64A 5mo4A-1snxA:
25.2		 5mo4A-1snxA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 621
VAL A 643
VAL A 654
HIS A 790
LEU A 799
ASP A 810
 STI  A   3 (-3.5A)
None
STI  A   3 (-4.3A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.38A 5mo4A-1t46A:
9.0		 5mo4A-1t46A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA X  37
MET X  58
LEU X  66
VAL X  67
HIS X 128
LEU X 137
ALA X 147
 STU  X 902 (-3.1A)
None
None
None
None
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.68A 5mo4A-2dq7X:
26.4		 5mo4A-2dq7X:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 184
ILE A 208
VAL A 220
HIS A 281
ALA A 319
 None
 0.61A 5mo4A-2eu9A:
7.4		 5mo4A-2eu9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 184
VAL A 204
ILE A 208
VAL A 220
ALA A 319
 None
 0.65A 5mo4A-2eu9A:
7.4		 5mo4A-2eu9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 208
VAL A 220
HIS A 281
LEU A 290
ALA A 319
 None
 0.75A 5mo4A-2eu9A:
7.4		 5mo4A-2eu9A:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 H8H  A 534 (-3.2A)
None
None
None
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.76A 5mo4A-2h8hA:
38.3		 5mo4A-2h8hA:
40.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.53A 5mo4A-2hckA:
37.5		 5mo4A-2hckA:
38.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 271
LEU A 300
VAL A 301
HIS A 362
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
None
None
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.53A 5mo4A-2hk5A:
26.7		 5mo4A-2hk5A:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
VAL A 291
MET A 292
LEU A 300
VAL A 301
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
None
1BM  A 499 ( 3.8A)
None
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.75A 5mo4A-2hk5A:
26.7		 5mo4A-2hk5A:
29.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
VAL A 289
MET A 290
ILE A 293
LEU A 298
VAL A 299
LEU A 370
ALA A 380
 GIN  A 600 (-3.1A)
None
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.56A 5mo4A-2hz0A:
7.5		 5mo4A-2hz0A:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 298
VAL A 299
HIS A 361
ALA A 380
ASP A 381
 GIN  A 600 (-4.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.3A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.55A 5mo4A-2hz0A:
7.5		 5mo4A-2hz0A:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 290
LEU A 298
VAL A 299
ALA A 380
ASP A 381
 GIN  A 600 (-3.2A)
GIN  A 600 (-4.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.69A 5mo4A-2hz0A:
7.5		 5mo4A-2hz0A:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 289
ILE A 293
LEU A 298
VAL A 299
HIS A 361
LEU A 370
ALA A 380
 None
GIN  A 600 (-4.5A)
GIN  A 600 (-4.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.70A 5mo4A-2hz0A:
7.5		 5mo4A-2hz0A:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 ALA A 452
MET A 475
VAL A 484
PHE A 542
HIS A 544
LEU A 553
 4ST  A1687 (-3.3A)
None
None
None
None
4ST  A1687 (-4.4A)
 0.75A 5mo4A-2j0jA:
27.0		 5mo4A-2j0jA:
30.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
VAL A  64
HIS A 125
LEU A 134
ALA A 144
 None
 0.46A 5mo4A-2jgzA:
16.2		 5mo4A-2jgzA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 452
MET A 475
VAL A 484
PHE A 542
HIS A 544
LEU A 553
 BII  A1687 (-3.5A)
None
None
None
None
BII  A1687 (-4.2A)
 0.65A 5mo4A-2jkmA:
27.2		 5mo4A-2jkmA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
MET A 292
LEU A 300
VAL A 301
HIS A 362
LEU A 371
ALA A 381
ASP A 382
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.9A)
None
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
 0.65A 5mo4A-2og8A:
7.4		 5mo4A-2og8A:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 614
MET A 637
VAL A 647
HIS A 776
LEU A 785
 None
 0.77A 5mo4A-2ogvA:
25.5		 5mo4A-2ogvA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 853
ILE A 902
PHE A 960
ALA A 981
ASP A 982
 MR9  A 301 (-3.5A)
MR9  A 301 (-4.1A)
MR9  A 301 ( 4.7A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
 0.65A 5mo4A-2p4iA:
22.2		 5mo4A-2p4iA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
VAL A 875
ILE A 902
HIS A 962
LEU A 971
ALA A 981
ASP A 982
 MR9  A 301 (-3.5A)
MR9  A 301 ( 4.8A)
MR9  A 301 (-4.1A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
 0.50A 5mo4A-2p4iA:
22.2		 5mo4A-2p4iA:
27.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 515
MET A 538
ILE A 541
HIS A 624
LEU A 633
ALA A 643
 None
 0.67A 5mo4A-2psqA:
26.6		 5mo4A-2psqA:
30.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		5 ALA B  67
LEU B  97
VAL B  98
HIS B 162
LEU B 171
 None
 0.64A 5mo4A-2qkwB:
20.1		 5mo4A-2qkwB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 749
LEU A 780
VAL A 781
HIS A 841
LEU A 850
 GW7  A   1 (-3.3A)
None
GW7  A   1 ( 4.7A)
None
GW7  A   1 (-4.2A)
 0.78A 5mo4A-2r4bA:
25.3		 5mo4A-2r4bA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1028
VAL A1050
MET A1051
VAL A1060
HIS A1130
 S91  A   1 (-3.2A)
None
None
None
None
 0.66A 5mo4A-2z8cA:
21.6		 5mo4A-2z8cA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 273
LEU A 302
VAL A 303
HIS A 365
LEU A 374
ALA A 384
 None
 0.58A 5mo4A-2zv7A:
26.5		 5mo4A-2zv7A:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum) 		no annotation 5 ALA C 123
VAL C 179
ILE C 136
LEU C 172
ALA C 168
 None
 0.75A 5mo4A-3a28C:
undetectable		 5mo4A-3a28C:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 515
MET A 538
HIS A 624
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
None
None
M33  A1996 (-4.5A)
None
 0.59A 5mo4A-3b2tA:
26.0		 5mo4A-3b2tA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 538
ILE A 541
HIS A 624
LEU A 633
ALA A 643
 None
None
None
M33  A1996 (-4.5A)
None
 0.76A 5mo4A-3b2tA:
26.0		 5mo4A-3b2tA:
26.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1108
MET A1131
PHE A1200
HIS A1202
ASP A1222
 CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 ( 4.8A)
CKK  A1500 (-4.2A)
CKK  A1500 (-4.5A)
 0.65A 5mo4A-3c1xA:
26.4		 5mo4A-3c1xA:
30.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 512
MET A 535
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.53A 5mo4A-3c4fA:
9.9		 5mo4A-3c4fA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
MET A 240
LEU A 248
VAL A 249
HIS A 312
LEU A 321
 None
 0.69A 5mo4A-3d7uA:
26.8		 5mo4A-3d7uA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
VAL A 239
MET A 240
VAL A 249
HIS A 312
LEU A 321
 None
 0.65A 5mo4A-3d7uA:
26.8		 5mo4A-3d7uA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ALA A 663
MET A 686
VAL A 695
HIS A 756
ASP A 776
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
 0.67A 5mo4A-3dkoA:
26.5		 5mo4A-3dkoA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 663
VAL A 695
ILE A 711
HIS A 756
LEU A 765
ASP A 776
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.73A 5mo4A-3dkoA:
26.5		 5mo4A-3dkoA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ALA A  80
MET A 104
VAL A 113
ALA A 192
ASP A 193
 None
 0.78A 5mo4A-3iecA:
19.6		 5mo4A-3iecA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ALA A  80
MET A 104
VAL A 113
HIS A 173
ALA A 192
 None
 0.72A 5mo4A-3iecA:
19.6		 5mo4A-3iecA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  46
VAL A  79
HIS A 147
LEU A 156
ALA A 166
 None
 0.60A 5mo4A-3mi9A:
19.8		 5mo4A-3mi9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 ALA A  49
VAL A  82
HIS A 142
LEU A 151
ALA A 161
 ADP  A 314 (-3.5A)
None
None
ADP  A 314 (-4.6A)
None
 0.53A 5mo4A-3nizA:
19.6		 5mo4A-3nizA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 ALA A  38
VAL A  72
HIS A 132
LEU A 141
ALA A 151
 None
 0.78A 5mo4A-3oz6A:
18.6		 5mo4A-3oz6A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 ALA A 576
MET A 600
VAL A 609
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.3A)
 0.58A 5mo4A-3ppzA:
7.1		 5mo4A-3ppzA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swd UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 ALA A 203
VAL A 228
ILE A  41
LEU A  34
ALA A  31
 None
 0.78A 5mo4A-3swdA:
undetectable		 5mo4A-3swdA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 443
MET A 464
LEU A 472
VAL A 473
HIS A 534
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
None
None
PP2  A   1 (-4.6A)
 0.61A 5mo4A-3sxsA:
8.2		 5mo4A-3sxsA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 512
MET A 535
HIS A 621
LEU A 630
ALA A 640
 07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
None
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.62A 5mo4A-3tt0A:
26.4		 5mo4A-3tt0A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 570
VAL A 601
PHE A 675
HIS A 677
LEU A 686
ASP A 697
 0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.2A)
0F4  A 902 (-4.1A)
0F4  A 902 (-4.5A)
None
 0.51A 5mo4A-3v5qA:
14.5		 5mo4A-3v5qA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 866
VAL A 899
HIS A1026
LEU A1035
ASP A1046
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.8A)
None
 0.71A 5mo4A-3vidA:
8.5		 5mo4A-3vidA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wye DIACETYL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING]

(Corynebacterium
glutamicum;
Klebsiella
pneumoniae) 		PF13561
(adh_short_C2) 		5 ALA A 121
VAL A 177
ILE A 134
LEU A 170
ALA A 166
 None
 0.80A 5mo4A-3wyeA:
undetectable		 5mo4A-3wyeA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
LEU A  62
VAL A  63
HIS A 123
LEU A 132
 38R  A 350 (-3.4A)
None
38R  A 350 ( 4.9A)
None
38R  A 350 (-4.3A)
 0.63A 5mo4A-3zduA:
16.5		 5mo4A-3zduA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 866
VAL A 899
HIS A1026
LEU A1035
ASP A1046
 B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
None
B49  A2000 (-4.5A)
None
 0.73A 5mo4A-4agdA:
9.2		 5mo4A-4agdA:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
LEU A  63
VAL A  64
HIS A 124
LEU A 133
 D15  A 500 (-3.4A)
None
None
None
D15  A 500 (-4.5A)
 0.52A 5mo4A-4aguA:
19.5		 5mo4A-4aguA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
LEU A  63
VAL A  64
HIS A 124
LEU A 133
 TC0  A 500 (-3.5A)
None
TC0  A 500 (-4.7A)
None
TC0  A 500 (-4.3A)
 0.73A 5mo4A-4bbmA:
19.4		 5mo4A-4bbmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  63
VAL A  94
ILE A 110
HIS A 155
LEU A 164
ALA A 174
 XZN  A1317 (-3.5A)
XZN  A1317 (-4.4A)
XZN  A1317 (-3.3A)
None
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.67A 5mo4A-4bc6A:
13.9		 5mo4A-4bc6A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 653
MET A 676
HIS A 764
LEU A 773
ALA A 783
ASP A 784
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.82A 5mo4A-4ckrA:
11.1		 5mo4A-4ckrA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ALA A 684
LEU A 720
VAL A 721
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.56A 5mo4A-4crsA:
12.9		 5mo4A-4crsA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 400
VAL A 423
MET A 424
VAL A 433
LEU A 501
 0SB  A 701 (-3.3A)
None
None
None
0SB  A 701 (-4.4A)
 0.74A 5mo4A-4f4pA:
24.2		 5mo4A-4f4pA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 853
VAL A 884
HIS A 947
LEU A 956
ALA A 966
 19S  A1201 (-3.3A)
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.63A 5mo4A-4hviA:
23.9		 5mo4A-4hviA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		5 ALA A 156
LEU A 189
PHE A 248
HIS A 250
LEU A 259
 None
 0.66A 5mo4A-4hzsA:
19.5		 5mo4A-4hzsA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 0J9  A 601 (-3.3A)
None
None
None
0J9  A 601 (-4.5A)
0J9  A 601 (-3.5A)
 0.58A 5mo4A-4k11A:
38.1		 5mo4A-4k11A:
40.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 506
ILE A 532
HIS A 615
LEU A 624
ALA A 634
 ACP  A 801 (-3.3A)
None
None
ACP  A 801 (-4.4A)
None
 0.65A 5mo4A-4k33A:
26.1		 5mo4A-4k33A:
26.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 506
MET A 529
ILE A 532
LEU A 624
ALA A 634
 ACP  A 801 (-3.3A)
None
None
ACP  A 801 (-4.4A)
None
 0.72A 5mo4A-4k33A:
26.1		 5mo4A-4k33A:
26.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  54
MET A  74
VAL A  83
HIS A 144
ALA A 163
 GOL  A 404 ( 3.1A)
None
GOL  A 403 (-4.1A)
None
GOL  A 403 ( 3.0A)
 0.62A 5mo4A-4lg4A:
16.9		 5mo4A-4lg4A:
20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 VGG  A 601 (-3.5A)
None
VGG  A 601 ( 4.8A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.55A 5mo4A-4lggA:
25.5		 5mo4A-4lggA:
37.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 293
VAL A 313
LEU A 322
VAL A 323
ALA A 403
 VGG  A 601 (-3.5A)
None
None
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.2A)
 0.76A 5mo4A-4lggA:
25.5		 5mo4A-4lggA:
37.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA A 388
VAL A 416
HIS A 480
LEU A 489
ALA A 499
 None
 0.80A 5mo4A-4o1oA:
13.4		 5mo4A-4o1oA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		6 ALA B 390
LEU B 417
VAL B 418
HIS B 483
LEU B 492
ALA B 502
 ACP  B 801 (-3.2A)
None
None
None
ACP  B 801 (-4.5A)
None
 0.75A 5mo4A-4oavB:
14.0		 5mo4A-4oavB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 642
VAL A 675
HIS A 809
LEU A 818
ASP A 829
 P30  A1001 (-3.4A)
None
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
None
 0.71A 5mo4A-4rt7A:
27.1		 5mo4A-4rt7A:
28.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 ALA A  35
LEU A  64
VAL A  65
HIS A 127
LEU A 136
ALA A 146
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 ( 4.8A)
None
 0.46A 5mo4A-4ueuA:
9.4		 5mo4A-4ueuA:
37.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  61
VAL A  92
HIS A 153
LEU A 162
ALA A 172
ASP A 173
 6UI  A 700 (-3.3A)
None
None
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
 0.69A 5mo4A-4usfA:
14.8		 5mo4A-4usfA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  72
MET A  94
VAL A 104
HIS A 174
LEU A 183
 KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.6A)
 0.71A 5mo4A-4wsqA:
19.0		 5mo4A-4wsqA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 501
VAL A 523
MET A 524
HIS A 610
ALA A 629
 40M  A1002 ( 4.1A)
None
40M  A1002 (-3.8A)
None
40M  A1002 (-3.0A)
 0.52A 5mo4A-4xcuA:
26.6		 5mo4A-4xcuA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 523
MET A 524
HIS A 610
LEU A 619
ALA A 629
 None
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.60A 5mo4A-4xcuA:
26.6		 5mo4A-4xcuA:
27.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 7 ALA B 288
VAL B 308
MET B 309
ILE B 312
LEU B 317
HIS B 380
LEU B 389
 1N1  B 601 (-3.5A)
None
1N1  B 601 (-3.7A)
None
None
None
1N1  B 601 (-4.3A)
 0.67A 5mo4A-4xeyB:
28.4		 5mo4A-4xeyB:
80.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 7 ALA B 288
VAL B 308
MET B 309
LEU B 317
HIS B 380
LEU B 389
ALA B 399
 1N1  B 601 (-3.5A)
None
1N1  B 601 (-3.7A)
None
None
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.60A 5mo4A-4xeyB:
28.4		 5mo4A-4xeyB:
80.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 7 ALA B 288
VAL B 308
MET B 309
LEU B 317
VAL B 318
HIS B 380
LEU B 389
 1N1  B 601 (-3.5A)
None
1N1  B 601 (-3.7A)
None
1N1  B 601 ( 4.3A)
None
1N1  B 601 (-4.3A)
 0.65A 5mo4A-4xeyB:
28.4		 5mo4A-4xeyB:
80.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
MET A 665
VAL A 675
HIS A 809
LEU A 818
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
None
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
 0.97A 5mo4A-4xufA:
11.6		 5mo4A-4xufA:
26.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 ALA A 428
LEU A 457
VAL A 458
HIS A 519
LEU A 528
 746  A 702 (-2.4A)
None
None
None
746  A 702 (-4.4A)
 0.78A 5mo4A-4y93A:
26.6		 5mo4A-4y93A:
34.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 512
MET A 535
HIS A 621
LEU A 630
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.47A 5mo4A-5a46A:
26.4		 5mo4A-5a46A:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  44
VAL A  76
HIS A 136
LEU A 145
ALA A 164
 51W  A 401 (-3.4A)
None
None
51W  A 401 (-4.5A)
None
 0.62A 5mo4A-5ci7A:
19.3		 5mo4A-5ci7A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 625
MET A 648
VAL A 658
HIS A 816
LEU A 825
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.61A 5mo4A-5grnA:
23.0		 5mo4A-5grnA:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1108
MET A1131
PHE A1200
HIS A1202
ALA A1221
 63K  A1401 (-3.5A)
None
None
None
63K  A1401 (-3.3A)
 0.72A 5mo4A-5horA:
5.6		 5mo4A-5horA:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 ALA A  41
VAL A  74
HIS A 134
LEU A 143
ALA A 156
 ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.43A 5mo4A-5hu3A:
19.0		 5mo4A-5hu3A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A  76
HIS A 136
LEU A 145
ALA A 155
ASP A 156
 65U  A 301 (-4.7A)
65U  A 301 (-3.3A)
None
65U  A 301 ( 3.9A)
65U  A 301 (-4.7A)
 0.59A 5mo4A-5hx6A:
22.4		 5mo4A-5hx6A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  43
MET A  65
VAL A  74
HIS A 134
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.73A 5mo4A-5j5tA:
12.5		 5mo4A-5j5tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ALA A 909
LEU A 939
VAL A 940
HIS A1007
LEU A1016
 ATP  A1200 (-3.5A)
None
None
None
ATP  A1200 (-4.6A)
 0.60A 5mo4A-5lpyA:
16.9		 5mo4A-5lpyA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ALA A 909
LEU A 939
VAL A 940
HIS A1007
LEU A1016
 ADP  A1200 (-3.5A)
None
None
None
ADP  A1200 (-4.7A)
 0.62A 5mo4A-5lpzA:
19.7		 5mo4A-5lpzA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 5 ALA A 754
VAL A 787
HIS A 857
LEU A 866
ALA A 876
 CJM  A1102 (-3.1A)
None
None
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
 0.50A 5mo4A-6b3eA:
20.1		 5mo4A-6b3eA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 5 ALA A 192
VAL A 249
HIS A 310
LEU A 319
ALA A 329
 BI9  A 501 (-3.3A)
None
None
BI9  A 501 (-4.7A)
NH4  A 506 ( 3.7A)
 0.48A 5mo4A-6bqlA:
18.8		 5mo4A-6bqlA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 5 ALA A 155
VAL A 212
HIS A 273
LEU A 282
ALA A 292
 H1N  A 501 (-3.4A)
H1N  A 501 (-4.9A)
None
H1N  A 501 (-4.8A)
H1N  A 501 ( 3.9A)
 0.47A 5mo4A-6ccfA:
16.1		 5mo4A-6ccfA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 5 ALA A 192
VAL A 249
HIS A 310
LEU A 319
ALA A 329
 F6J  A 501 (-3.4A)
None
None
F6J  A 501 (-4.5A)
F6J  A 501 ( 4.0A)
 0.56A 5mo4A-6cmjA:
19.0		 5mo4A-6cmjA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 5 ALA A 211
LEU A 245
VAL A 246
HIS A 309
LEU A 318
 CJT  A 502 (-3.4A)
None
None
None
CJT  A 502 (-4.7A)
 0.55A 5mo4A-6f3dA:
20.0		 5mo4A-6f3dA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 5 ALA U  42
VAL U  75
HIS U 135
LEU U 144
ALA U 156
 DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
None
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.60A 5mo4A-6fdyU:
15.5		 5mo4A-6fdyU:
undetectable