SIMILAR PATTERNS OF AMINO ACIDS FOR 5MLM_A_STRA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9l CLATHRIN

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link) 		5 PHE A  37
ILE A  52
SER A  97
VAL A  79
ILE A  80
 None
 1.34A 5mlmA-1c9lA:
undetectable		 5mlmA-1c9lA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT

(Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 PHE A 516
ILE A 512
ASN A 279
VAL A 108
ILE A 264
 None
 1.04A 5mlmA-1e6vA:
undetectable		 5mlmA-1e6vA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ez4 LACTATE
DEHYDROGENASE

(Lactobacillus
pentosus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 PHE A 129
ALA A 136
SER A 161
VAL A  93
ILE A  94
 None
NAD  A1352 (-4.2A)
NAD  A1352 (-2.8A)
None
None
 1.44A 5mlmA-1ez4A:
7.6		 5mlmA-1ez4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggv DIENELACTONE
HYDROLASE

(Pseudomonas
putida) 		PF01738
(DLH) 		5 PHE A 227
ALA A 107
SER A 113
ILE A  31
PRO A  29
 None
 1.39A 5mlmA-1ggvA:
3.0		 5mlmA-1ggvA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktw IOTA-CARRAGEENASE

(Alteromonas sp.
ATCC 43554) 		PF12708
(Pectate_lyase_3) 		5 PHE A 140
ILE A 172
ALA A 185
VAL A 161
ILE A 187
 None
None
CL  A 530 (-3.5A)
None
None
 1.11A 5mlmA-1ktwA:
undetectable		 5mlmA-1ktwA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 ALA A  56
SER A  54
VAL A  49
ILE A  35
PRO A  52
 None
 1.24A 5mlmA-1l0wA:
undetectable		 5mlmA-1l0wA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldn L-LACTATE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 PHE A 129
ALA A 136
SER A 161
VAL A  93
ILE A  94
 None
NAD  A 352 (-4.3A)
NAD  A 352 (-3.1A)
None
None
 1.39A 5mlmA-1ldnA:
7.5		 5mlmA-1ldnA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		5 PHE A 439
ALA A 458
SER A 585
VAL A 446
PRO A 583
 None
 1.37A 5mlmA-1lzxA:
undetectable		 5mlmA-1lzxA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onl GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Thermus
thermophilus) 		PF01597
(GCV_H) 		5 ILE A 100
ALA A  55
VAL A  58
ILE A  68
PRO A  44
 None
 1.30A 5mlmA-1onlA:
undetectable		 5mlmA-1onlA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0n ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Bacillus
subtilis) 		PF01070
(FMN_dh) 		5 MET A 310
PHE A  30
ILE A 309
SER A  56
VAL A 266
 None
 1.48A 5mlmA-1p0nA:
2.1		 5mlmA-1p0nA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)

(Rhinovirus A) 		PF00073
(Rhv) 		5 MET 1 143
ILE 1 141
VAL 1 234
ILE 1 131
PRO 1 129
 None
 1.13A 5mlmA-1r1a1:
undetectable		 5mlmA-1r1a1:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C)
PF13177
(DNA_pol3_delta2) 		5 PHE D 327
ILE C 318
ASN D 334
ALA D 298
SER E 175
 None
 1.25A 5mlmA-1sxjD:
undetectable		 5mlmA-1sxjD:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 LYS A 612
ASN A 425
ALA A 152
SER A 762
ILE A 156
 None
 1.47A 5mlmA-1tmoA:
undetectable		 5mlmA-1tmoA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis) 		PF02595
(Gly_kinase) 		5 ILE A  23
ALA A 334
VAL A 284
ILE A 315
CYH A 316
 None
 1.34A 5mlmA-1to6A:
2.9		 5mlmA-1to6A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcn CTP SYNTHETASE

(Thermus
thermophilus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 LYS A 254
ALA A 326
SER A 527
ILE A 328
PRO A 529
 None
 1.39A 5mlmA-1vcnA:
3.3		 5mlmA-1vcnA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 ILE A 424
ALA A 443
SER A 447
VAL A 358
ILE A 427
 None
 1.41A 5mlmA-1x9nA:
undetectable		 5mlmA-1x9nA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csu 457AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		5 PHE A 179
ILE A 132
ALA A 186
VAL A 182
ILE A 125
 None
 1.44A 5mlmA-2csuA:
3.0		 5mlmA-2csuA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de6 FERREDOXIN COMPONENT
OF CARBAZOLE

(Pseudomonas
resinovorans) 		PF00355
(Rieske) 		5 ILE D  19
ALA D  71
ILE D  63
CYH D  65
PRO D  66
 None
None
None
FES  D 201 (-2.3A)
None
 1.23A 5mlmA-2de6D:
undetectable		 5mlmA-2de6D:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF00156
(Pribosyltran) 		5 PHE A  28
ALA A  40
SER A  44
VAL A  31
ILE A  15
 None
 1.28A 5mlmA-2dy0A:
undetectable		 5mlmA-2dy0A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghi TRANSPORT PROTEIN

(Plasmodium
yoelii) 		PF00005
(ABC_tran) 		5 PHE A  20
ILE A  18
SER A  90
VAL A  83
ILE A  78
 None
 1.32A 5mlmA-2ghiA:
undetectable		 5mlmA-2ghiA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Staphylococcus
aureus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 258
ALA A 186
SER A 246
VAL A 179
ILE A 241
 None
 1.39A 5mlmA-2gqdA:
undetectable		 5mlmA-2gqdA:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2v6g PROGESTERONE
5-BETA-REDUCTASE

(Digitalis
lanata) 		PF01370
(Epimerase) 		6 LYS A 147
MET A 150
PHE A 153
MET A 215
SER A 248
CYH A 352
 NAP  A1390 (-4.5A)
None
None
None
None
None
 0.85A 5mlmA-2v6gA:
58.6		 5mlmA-2v6gA:
87.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2v6g PROGESTERONE
5-BETA-REDUCTASE

(Digitalis
lanata) 		PF01370
(Epimerase) 		7 MET A 150
PHE A 153
ASN A 205
MET A 215
ALA A 243
SER A 248
CYH A 352
 None
 0.62A 5mlmA-2v6gA:
58.6		 5mlmA-2v6gA:
87.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrn PROTEASE I

(Deinococcus
radiodurans) 		PF01965
(DJ-1_PfpI) 		5 ILE A  12
ALA A  34
VAL A 177
ILE A  32
PRO A  28
 None
 1.46A 5mlmA-2vrnA:
4.3		 5mlmA-2vrnA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzk GLUTAMATE
N-ACETYLTRANSFERASE
2 BETA CHAIN

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		5 PHE B 328
ILE B 326
ALA B 279
VAL B 268
ILE B 364
 None
 1.39A 5mlmA-2vzkB:
undetectable		 5mlmA-2vzkB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybq METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00590
(TP_methylase) 		5 ILE A 194
ALA A 210
VAL A 247
ILE A 245
PRO A 231
 None
 1.19A 5mlmA-2ybqA:
undetectable		 5mlmA-2ybqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzj 167AA LONG
HYPOTHETICAL DUTPASE

(Sulfurisphaera
tokodaii) 		PF00692
(dUTPase) 		5 MET A 139
ILE A  41
ALA A 129
SER A 133
ILE A 127
 None
 1.39A 5mlmA-2yzjA:
undetectable		 5mlmA-2yzjA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 5 PHE A 500
ILE A 385
SER A 524
VAL A 533
PRO A 378
 None
 1.38A 5mlmA-3ahmA:
undetectable		 5mlmA-3ahmA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dby UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		5 PHE A 100
ILE A 101
MET A 231
ALA A  33
ILE A  94
 None
 1.33A 5mlmA-3dbyA:
undetectable		 5mlmA-3dbyA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do5 HOMOSERINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 PHE A  34
ILE A   4
ALA A  86
SER A 113
VAL A  16
 None
 1.41A 5mlmA-3do5A:
8.3		 5mlmA-3do5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9d ZGC:56074

(Danio rerio) 		PF00300
(His_Phos_1) 		5 MET A 180
PHE A 223
ILE A   8
ALA A 185
ILE A 187
 None
 1.39A 5mlmA-3e9dA:
undetectable		 5mlmA-3e9dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4w PUTATIVE HEXULOSE 6
PHOSPHATE SYNTHASE

(Salmonella
enterica) 		PF00215
(OMPdecase) 		5 MET A 110
ALA A  99
SER A  70
ILE A  96
CYH A  95
 None
 1.39A 5mlmA-3f4wA:
2.7		 5mlmA-3f4wA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE

(Comamonas
testosteroni) 		PF00155
(Aminotran_1_2) 		5 ILE A 511
ASN A  29
MET A  32
VAL A 482
ILE A 475
 None
 1.13A 5mlmA-3fddA:
undetectable		 5mlmA-3fddA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1

(Klebsiella
pneumoniae) 		PF00563
(EAL)
PF04940
(BLUF) 		5 MET A 297
ILE A 271
ALA A 220
SER A 258
ILE A 238
 None
 1.44A 5mlmA-3gg0A:
undetectable		 5mlmA-3gg0A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1

(Staphylococcus
aureus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 PHE A 115
ALA A 122
SER A 147
VAL A  79
ILE A  80
 None
NAD  A 500 (-4.2A)
NAD  A 500 (-3.3A)
None
None
 1.38A 5mlmA-3h3jA:
8.4		 5mlmA-3h3jA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jur EXO-POLY-ALPHA-D-GAL
ACTURONOSIDASE

(Thermotoga
maritima) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		5 MET A 249
ILE A 251
VAL A 264
ILE A 241
PRO A 218
 None
 1.26A 5mlmA-3jurA:
undetectable		 5mlmA-3jurA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfo NUCLEOPORIN NUP133

(Saccharomyces
cerevisiae) 		no annotation 5 PHE A1016
ILE A1061
VAL A1041
ILE A1045
PRO A1079
 None
 1.48A 5mlmA-3kfoA:
undetectable		 5mlmA-3kfoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9d PUTATIVE GTP
PYROPHOSPHOKINASE

(Streptococcus
mutans) 		PF04607
(RelA_SpoT) 		5 PHE A  21
ILE A  76
MET A  97
VAL A 119
ILE A 140
 None
 1.42A 5mlmA-3l9dA:
undetectable		 5mlmA-3l9dA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mt0 UNCHARACTERIZED
PROTEIN PA1789

(Pseudomonas
aeruginosa) 		PF00582
(Usp) 		5 ILE A  78
SER A   6
VAL A   9
ILE A  90
CYH A  87
 None
 1.41A 5mlmA-3mt0A:
undetectable		 5mlmA-3mt0A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne2 PROBABLE AQUAPORIN
AQPM

(Archaeoglobus
fulgidus) 		PF00230
(MIP) 		5 ILE A 105
ALA A 233
VAL A  86
ILE A  88
PRO A 201
 None
 1.42A 5mlmA-3ne2A:
undetectable		 5mlmA-3ne2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3num SERINE PROTEASE
HTRA1

(Homo sapiens) 		PF13365
(Trypsin_2) 		5 PHE A 363
ILE A 360
ALA A 328
SER A 205
ILE A 342
 None
 1.20A 5mlmA-3numA:
undetectable		 5mlmA-3numA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6b CELL DIVISION
CONTROL PROTEIN 53
DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1

(Saccharomyces
cerevisiae) 		PF03556
(Cullin_binding)
PF10557
(Cullin_Nedd8) 		5 MET B 759
ILE B 755
ALA A 253
VAL B 771
ILE B 793
 None
 1.28A 5mlmA-3o6bB:
undetectable		 5mlmA-3o6bB:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qj4 RENALASE

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		5 ILE A 273
VAL A 266
ILE A 221
CYH A 220
PRO A 219
 None
 1.47A 5mlmA-3qj4A:
5.9		 5mlmA-3qj4A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 PHE A 680
ILE A 494
ALA A 651
SER A 510
ILE A 667
 None
 1.25A 5mlmA-3rimA:
undetectable		 5mlmA-3rimA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rvx PEPTIDASE 1

(Dermatophagoides
pteronyssinus) 		PF00112
(Peptidase_C1) 		5 ILE A 127
ALA A  42
SER A  38
VAL A 175
ILE A 138
 None
 1.43A 5mlmA-3rvxA:
undetectable		 5mlmA-3rvxA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sks PUTATIVE
OLIGOENDOPEPTIDASE F

(Bacillus
anthracis) 		no annotation 5 PHE A 500
ILE A 385
SER A 524
VAL A 533
PRO A 378
 None
 1.29A 5mlmA-3sksA:
undetectable		 5mlmA-3sksA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ILE A 355
ALA A 111
SER A 141
VAL A 211
ILE A 212
 None
 1.23A 5mlmA-3sunA:
undetectable		 5mlmA-3sunA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 MET A  18
ALA A 126
SER A  95
VAL A  91
ILE A  92
 None
 1.47A 5mlmA-3tz6A:
2.4		 5mlmA-3tz6A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE

(Methanocaldococcus
jannaschii) 		PF05889
(SepSecS) 		5 ILE A  79
ALA A 238
SER A 285
VAL A 280
ILE A 279
 None
 1.37A 5mlmA-3wksA:
3.2		 5mlmA-3wksA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh9 DELTA

(Bacillus
subtilis) 		PF06144
(DNA_pol3_delta) 		5 PHE B 195
ILE B 196
ALA B 171
VAL B 207
ILE B 202
 None
 1.33A 5mlmA-3zh9B:
undetectable		 5mlmA-3zh9B:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif PENTON PROTEIN

(Bovine
mastadenovirus
B) 		PF01686
(Adeno_Penton_B) 		5 PHE M 239
ILE M 262
MET M 173
VAL M 139
CYH M 235
 None
 1.38A 5mlmA-3zifM:
undetectable		 5mlmA-3zifM:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00111
(Fer2)
PF14574
(DUF4445) 		5 ALA X 296
SER X 359
VAL X 294
ILE X 345
PRO X 347
 None
 1.44A 5mlmA-3zyyX:
undetectable		 5mlmA-3zyyX:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		5 ILE A 526
ALA A 630
SER A 346
VAL A 529
ILE A 531
 None
 1.26A 5mlmA-4bl3A:
undetectable		 5mlmA-4bl3A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsq CATHEPSIN S

(Mus musculus) 		PF00112
(Peptidase_C1) 		5 PHE A 198
ILE A 201
ALA A 209
VAL A 153
ILE A 207
 None
 1.45A 5mlmA-4bsqA:
undetectable		 5mlmA-4bsqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE SUBUNIT
RPT4

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 ILE L 262
ALA L 285
VAL L 252
ILE L 251
PRO L 247
 None
 1.25A 5mlmA-4cr4L:
undetectable		 5mlmA-4cr4L:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eag EG:132E8.2 PROTEIN

(Drosophila
melanogaster) 		PF16579
(AdenylateSensor) 		5 ILE A 464
MET A 474
ALA A 575
ILE A 577
CYH A 573
 None
 1.37A 5mlmA-4eagA:
undetectable		 5mlmA-4eagA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		5 PHE A 460
ILE A 461
ALA A 453
ILE A 451
CYH A 450
 None
 1.38A 5mlmA-4ex4A:
undetectable		 5mlmA-4ex4A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN

(Francisella
tularensis) 		PF02230
(Abhydrolase_2) 		5 PHE A  36
ILE A 216
ALA A  12
ILE A  43
CYH A  15
 None
 1.30A 5mlmA-4f21A:
2.3		 5mlmA-4f21A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
NAD-BINDING

(Dyadobacter
fermentans) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 PHE A   7
ILE A   5
ALA A 142
VAL A  91
ILE A  61
 None
 0.88A 5mlmA-4gbjA:
7.0		 5mlmA-4gbjA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		5 PHE A 374
ILE A 380
MET A 391
ILE A 408
PRO A 434
 None
 1.41A 5mlmA-4gfjA:
undetectable		 5mlmA-4gfjA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h18 CMT1

(Corynebacterium
glutamicum) 		PF00756
(Esterase) 		5 LYS A 130
PHE A 126
ALA A 208
ILE A 102
PRO A 100
 None
 1.46A 5mlmA-4h18A:
undetectable		 5mlmA-4h18A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12

(Saccharomyces
cerevisiae) 		no annotation 5 MET A 156
ILE A 170
SER A 182
VAL A 198
ILE A 199
 None
 1.38A 5mlmA-4h5iA:
undetectable		 5mlmA-4h5iA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		5 PHE A 182
ILE A 181
MET A 247
ALA A 154
ILE A 150
 None
 1.16A 5mlmA-4hjwA:
undetectable		 5mlmA-4hjwA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isb LONG CHAIN FATTY
ACID COA LIGASE
FADD10

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 PHE A 108
ILE A 105
ALA A 120
SER A  82
ILE A  72
 None
 1.46A 5mlmA-4isbA:
4.5		 5mlmA-4isbA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		5 PHE A 132
ILE A  46
ALA A 121
ILE A  21
PRO A  77
 None
 1.47A 5mlmA-4kpnA:
undetectable		 5mlmA-4kpnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmb CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		5 ILE A 226
MET A 101
ALA A 255
SER A 266
PRO A 296
 PLP  A 403 ( 4.7A)
CYS  A 402 (-4.5A)
None
None
PLP  A 403 (-4.1A)
 1.38A 5mlmA-4lmbA:
undetectable		 5mlmA-4lmbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln1 L-LACTATE
DEHYDROGENASE 1

(Bacillus cereus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 PHE A 114
ALA A 121
SER A 146
VAL A  78
ILE A  79
 None
 1.47A 5mlmA-4ln1A:
10.1		 5mlmA-4ln1A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1q L-LACTATE
DEHYDROGENASE

([Bacillus]
selenitireducens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 PHE A 113
ALA A 120
SER A 145
VAL A  77
ILE A  78
 None
 1.38A 5mlmA-4m1qA:
8.8		 5mlmA-4m1qA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 ILE A 316
ASN A 572
ALA A 563
SER A 567
ILE A 559
 None
EDO  A 612 ( 4.5A)
EDO  A 612 ( 4.1A)
EDO  A 612 (-2.4A)
None
 0.99A 5mlmA-4ph9A:
undetectable		 5mlmA-4ph9A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 PHE A  77
ILE A  80
ALA A 359
SER A 356
ILE A 384
 None
 1.26A 5mlmA-4phcA:
undetectable		 5mlmA-4phcA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3n MGS-M5

(unidentified) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 PHE A 112
ALA A 119
SER A 144
VAL A  76
ILE A  77
 None
 1.40A 5mlmA-4q3nA:
9.6		 5mlmA-4q3nA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnu ASPARTOACYLASE

(Homo sapiens) 		PF04952
(AstE_AspA) 		5 PHE A 209
ILE A 206
ALA A 171
SER A 108
ILE A 111
 None
 1.20A 5mlmA-4tnuA:
undetectable		 5mlmA-4tnuA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnx NETRIN-4

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		5 MET A  94
PHE A 134
MET A 142
ALA A 109
PRO A  91
 None
None
None
NAG  A 503 ( 4.5A)
None
 1.46A 5mlmA-4wnxA:
undetectable		 5mlmA-4wnxA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa7 NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio harveyi) 		PF04205
(FMN_bind) 		5 PHE A  66
ILE A  50
SER A 167
VAL A 131
ILE A  55
 None
 1.27A 5mlmA-4xa7A:
undetectable		 5mlmA-4xa7A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru HEN1

(Capnocytophaga
gingivalis) 		no annotation 5 MET C 165
ILE C 116
MET C   1
VAL C  48
ILE C   5
 None
 1.28A 5mlmA-4xruC:
6.1		 5mlmA-4xruC:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0z AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		5 PHE A  86
ILE A  72
ALA A  57
SER A 161
VAL A 281
 None
 1.36A 5mlmA-4z0zA:
undetectable		 5mlmA-4z0zA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		5 PHE A  86
ILE A  72
ALA A  57
SER A 161
VAL A 281
 None
 1.39A 5mlmA-4z11A:
undetectable		 5mlmA-4z11A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 ILE A 232
SER A 165
VAL A 244
ILE A 208
PRO A 163
 None
 1.37A 5mlmA-4ztxA:
2.1		 5mlmA-4ztxA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		5 PHE A 549
ASN A 510
ALA A  54
VAL A  65
ILE A  77
 None
 1.35A 5mlmA-5a29A:
undetectable		 5mlmA-5a29A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Coccidioides
immitis) 		PF00149
(Metallophos) 		5 ILE A 233
ALA A 251
SER A 275
ILE A 248
CYH A 246
 None
 1.27A 5mlmA-5b8iA:
undetectable		 5mlmA-5b8iA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dag PROTEIN AF-10

(Homo sapiens) 		PF13831
(PHD_2)
PF13832
(zf-HC5HC2H_2) 		5 ILE A 139
ALA A 153
VAL A 168
CYH A  85
PRO A  86
 None
None
None
ZN  A 304 (-2.3A)
None
 1.07A 5mlmA-5dagA:
undetectable		 5mlmA-5dagA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens) 		PF04858
(TH1) 		5 PHE B 317
ILE B 359
ALA B 308
VAL B 312
ILE B 310
 None
 1.25A 5mlmA-5l3xB:
undetectable		 5mlmA-5l3xB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7z MATERNAL PROTEIN
EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 5 MET A 293
ILE A 297
ALA A 265
VAL A  36
ILE A 136
 None
 1.24A 5mlmA-5l7zA:
undetectable		 5mlmA-5l7zA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l80 MATERNAL PROTEIN
EXUPERANTIA,MATERNAL
PROTEIN EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 5 MET A 240
ILE A 244
ALA A 212
VAL A  36
ILE A 136
 None
 1.15A 5mlmA-5l80A:
undetectable		 5mlmA-5l80A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5x DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA135

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF06883
(RNA_pol_Rpa2_4) 		5 MET B1013
ILE B1026
VAL B 775
ILE B 776
PRO B 945
 None
 1.36A 5mlmA-5m5xB:
undetectable		 5mlmA-5m5xB:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlh -

(-) 		no annotation 5 ILE A 156
ALA A 242
ILE A 350
CYH A 352
PRO A 353
 None
None
XOG  A 402 (-4.8A)
XOG  A 402 (-3.8A)
None
 1.45A 5mlmA-5mlhA:
62.8		 5mlmA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlh -

(-) 		no annotation 11 LYS A 147
PHE A 153
ILE A 156
ASN A 205
MET A 215
ALA A 243
SER A 248
VAL A 347
ILE A 350
CYH A 352
PRO A 353
 XOG  A 402 ( 2.7A)
XOG  A 402 (-3.9A)
None
XOG  A 402 (-2.8A)
XOG  A 402 ( 4.2A)
XOG  A 402 ( 4.2A)
XOG  A 402 ( 4.6A)
XOG  A 402 (-3.6A)
XOG  A 402 (-4.8A)
XOG  A 402 (-3.8A)
None
 0.55A 5mlmA-5mlhA:
62.8		 5mlmA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp2 TYPE II SECRETION
SYSTEM PROTEIN D

(Pseudomonas
aeruginosa) 		no annotation 5 ILE A 191
ALA A 174
SER A 106
VAL A 148
ILE A 184
 None
 1.08A 5mlmA-5mp2A:
undetectable		 5mlmA-5mp2A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 5 PHE A 453
ILE A 454
ALA A 446
ILE A 444
CYH A 443
 None
 1.33A 5mlmA-5oasA:
2.1		 5mlmA-5oasA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sui RIBOSOME BIOGENESIS
PROTEIN NSA1

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A  58
ALA A 162
ILE A  64
CYH A 149
PRO A 150
 None
 1.46A 5mlmA-5suiA:
undetectable		 5mlmA-5suiA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4x UDP-GLUCOSE
6-DEHYDROGENASE

(Homo sapiens) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 PHE A 314
ILE A 318
ALA A 408
VAL A 411
ILE A 331
 None
 1.27A 5mlmA-5w4xA:
4.9		 5mlmA-5w4xA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		no annotation 5 PHE A  77
ILE A  80
ALA A 359
SER A 356
ILE A 384
 None
 1.36A 5mlmA-5w6mA:
undetectable		 5mlmA-5w6mA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 5 MET A 599
PHE A 479
ILE A 600
MET A 367
PRO A 612
 None
 1.36A 5mlmA-5xiiA:
undetectable		 5mlmA-5xiiA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xil PUTATIVE PROLYL-TRNA
SYNTHETASE

(Leishmania
major) 		no annotation 5 PHE A 593
ALA A 579
VAL A 605
ILE A 543
CYH A 581
 None
 1.18A 5mlmA-5xilA:
undetectable		 5mlmA-5xilA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR

(Synechocystis
sp. PCC 6803) 		no annotation 5 PHE A 106
ILE A 107
MET A 297
ALA A 272
ILE A 146
 None
 1.28A 5mlmA-5y2wA:
undetectable		 5mlmA-5y2wA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 5 MET A 147
ILE A 169
ALA A 221
ILE A 203
PRO A 179
 None
 1.30A 5mlmA-6at7A:
undetectable		 5mlmA-6at7A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 5 PHE A   5
ILE A  14
MET A 795
ALA A 112
VAL A 776
 None
 1.13A 5mlmA-6bfiA:
undetectable		 5mlmA-6bfiA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bka NITRONATE
MONOOXYGENASE

(Cyberlindnera
mrakii) 		no annotation 5 PHE A  12
ILE A  41
ALA A 238
ILE A  19
PRO A  22
 None
None
FMN  A 401 ( 4.0A)
None
FMN  A 401 (-4.5A)
 1.31A 5mlmA-6bkaA:
2.0		 5mlmA-6bkaA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Acinetobacter
baumannii) 		no annotation 5 ILE A 261
MET A 143
ALA A 230
VAL A 306
ILE A 251
 None
 1.38A 5mlmA-6cauA:
5.5		 5mlmA-6cauA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 5 PHE A 423
ASN A 263
ALA A 313
ILE A 378
PRO A 294
 None
 1.26A 5mlmA-6chjA:
undetectable		 5mlmA-6chjA:
11.95