SIMILAR PATTERNS OF AMINO ACIDS FOR 5MIO_B_LOCB502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2r PROTEIN
(TRYPTOPHANYL TRNA
SYNTHETASE)

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		5 LEU A 272
ALA A 220
MET A 193
ILE A 213
ILE A  16
 None
 1.03A 5mioB-1d2rA:
undetectable		 5mioB-1d2rA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 5 LEU B 595
ALA B 815
LEU B 549
ALA B 885
ILE B 551
 None
 1.10A 5mioB-1ej6B:
undetectable		 5mioB-1ej6B:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g61 TRANSLATION
INITIATION FACTOR 6

(Methanocaldococcus
jannaschii) 		PF01912
(eIF-6) 		5 LEU A2020
LEU A2107
LEU A2070
ILE A2053
ILE A2084
 None
 0.94A 5mioB-1g61A:
undetectable		 5mioB-1g61A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6u INTERNALIN H

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		5 LEU A 103
ALA A  83
LEU A  53
ILE A  78
LYS A  58
 None
 0.99A 5mioB-1h6uA:
undetectable		 5mioB-1h6uA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 198
 None
 1.08A 5mioB-1htdA:
undetectable		 5mioB-1htdA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8a ENDO-1,4-BETA-XYLANA
SE A

(Thermotoga
maritima) 		PF06452
(CBM9_1) 		5 LEU A  52
LEU A 184
ASN A 183
ILE A 150
ILE A  25
 None
 1.01A 5mioB-1i8aA:
undetectable		 5mioB-1i8aA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izo CYTOCHROME P450
152A1

(Bacillus
subtilis) 		PF00067
(p450) 		5 LEU A 241
LEU A 102
LEU A 214
ALA A 218
ILE A 198
 None
 1.07A 5mioB-1izoA:
undetectable		 5mioB-1izoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko0 DIAMINOPIMELATE
DECARBOXYLASE

(Escherichia
coli) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A 175
LEU A 127
LEU A 185
ILE A 166
ILE A 188
 None
 1.09A 5mioB-1ko0A:
undetectable		 5mioB-1ko0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		5 LEU A 286
ALA A 259
ASN A 254
ALA A 234
ILE A 231
 None
 0.81A 5mioB-1l8wA:
undetectable		 5mioB-1l8wA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A   8
LEU A  33
ALA A  21
ALA A 141
ILE A  11
 None
None
None
FAD  A 459 (-4.5A)
FAD  A 459 (-4.5A)
 1.07A 5mioB-1lvlA:
undetectable		 5mioB-1lvlA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mus TN5 TRANSPOSASE

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5)
PF14706
(Tnp_DNA_bind) 		5 LEU A 356
LEU A  38
ALA A  60
ILE A  64
ILE A  46
 None
 1.06A 5mioB-1musA:
undetectable		 5mioB-1musA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0u BSTDEAD

(Geobacillus
stearothermophilus) 		PF00270
(DEAD) 		5 LEU A 185
ALA A  38
ALA A  75
ILE A  77
ILE A 129
 None
 1.03A 5mioB-1q0uA:
undetectable		 5mioB-1q0uA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 CYH A 929
LEU A 926
ALA A 889
LEU A 885
ILE A 806
 None
 1.08A 5mioB-1sojA:
undetectable		 5mioB-1sojA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 LEU A 517
LEU A 511
ALA A 495
THR A 609
ALA A 611
 None
 0.92A 5mioB-1w99A:
undetectable		 5mioB-1w99A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1

(Mus musculus) 		PF00104
(Hormone_recep) 		5 LEU A 345
LEU A 438
ALA A 434
THR A 273
ALA A 270
 PEF  A 201 (-4.2A)
None
PEF  A 201 ( 3.8A)
None
PEF  A 201 ( 4.4A)
 1.09A 5mioB-1yp0A:
undetectable		 5mioB-1yp0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp1 FII

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 197
 None
 1.02A 5mioB-1yp1A:
undetectable		 5mioB-1yp1A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 LEU A 410
LEU A 436
ASN A 437
LYS A 441
ILE A 397
 None
 1.06A 5mioB-2bucA:
undetectable		 5mioB-2bucA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		5 LEU A1176
MET A1179
ILE A1235
LYS A1153
ILE A1148
 None
 1.07A 5mioB-2ec5A:
undetectable		 5mioB-2ec5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fo1 LIN-12 PROTEIN

(Caenorhabditis
elegans) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU E1113
LEU E1100
ALA E1061
LEU E1057
ALA E1089
 None
 1.08A 5mioB-2fo1E:
undetectable		 5mioB-2fo1E:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		5 LEU A  49
ASN A  59
ALA A   4
ILE A   6
ILE A  63
 None
 0.96A 5mioB-2g4oA:
undetectable		 5mioB-2g4oA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gca FOLYLPOLYGLUTAMATE
SYNTHASE

(Lactobacillus
casei) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A 415
LEU A 395
THR A 337
ILE A 312
ILE A 310
 None
 1.02A 5mioB-2gcaA:
2.4		 5mioB-2gcaA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2krs PROBABLE ENTEROTOXIN

(Clostridium
perfringens) 		PF08239
(SH3_3) 		5 LEU A  27
ASN A  12
ALA A  54
ILE A  59
ILE A  45
 None
 1.03A 5mioB-2krsA:
undetectable		 5mioB-2krsA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		5 LEU A 242
ASN A 165
ALA A 160
ILE A 155
ILE A 127
 None
 1.09A 5mioB-2o1sA:
undetectable		 5mioB-2o1sA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A  46
LEU A 117
THR A 130
ILE A 109
ILE A 172
 None
 1.08A 5mioB-2oi6A:
undetectable		 5mioB-2oi6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I

(Schizosaccharomyces
pombe) 		no annotation 5 CYH G 132
LEU G 128
LEU G 167
THR G 177
ILE G 314
 None
 1.08A 5mioB-2ooxG:
undetectable		 5mioB-2ooxG:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3v INOSITOL-1-MONOPHOSP
HATASE

(Thermotoga
maritima) 		PF00459
(Inositol_P) 		5 LEU A1179
ALA A1113
ALA A1186
ILE A1208
ILE A1135
 None
 1.06A 5mioB-2p3vA:
undetectable		 5mioB-2p3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q42 PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 2

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 LEU A  47
ALA A  72
ASN A  63
ALA A  33
ILE A  37
 None
 0.98A 5mioB-2q42A:
undetectable		 5mioB-2q42A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Pseudomonas
syringae group
genomosp. 3) 		PF04198
(Sugar-bind) 		5 LEU A 283
ALA A 100
LEU A 104
ILE A 116
ILE A 114
 None
 0.98A 5mioB-2r5fA:
undetectable		 5mioB-2r5fA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 167
LEU A  65
ALA A 123
ILE A 125
ILE A  76
 None
 0.87A 5mioB-2v7bA:
2.0		 5mioB-2v7bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2k D-MANDELATE
DEHYDROGENASE

(Rhodotorula
graminis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 CYH B 223
THR B 117
ALA B 121
ILE B 125
ILE B 178
 None
 1.00A 5mioB-2w2kB:
undetectable		 5mioB-2w2kB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 LEU A 598
THR A 724
ALA A 715
ILE A 712
ILE A  79
 PGR  A1742 (-4.0A)
None
None
None
None
 1.03A 5mioB-2xe4A:
2.5		 5mioB-2xe4A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 LEU A 439
ALA A 373
THR A  40
ALA A 317
ILE A 437
 None
None
NAG  A 802 ( 4.0A)
None
None
 1.07A 5mioB-2yp2A:
undetectable		 5mioB-2yp2A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Corynebacterium
glutamicum) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 LEU A 252
ALA A 269
LEU A 416
ALA A 414
ILE A 412
 None
 1.06A 5mioB-2zciA:
undetectable		 5mioB-2zciA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zs0 EXTRACELLULAR GIANT
HEMOGLOBIN MAJOR
GLOBIN SUBUNIT B1

(Oligobrachia
mashikoi) 		PF00042
(Globin) 		5 LEU D 110
ALA D 113
ALA D  72
ILE D 137
ILE D  76
 HEM  D 200 (-3.8A)
None
HEM  D 200 ( 4.7A)
None
None
 1.03A 5mioB-2zs0D:
undetectable		 5mioB-2zs0D:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans) 		PF00903
(Glyoxalase) 		5 ALA A 188
LEU A 147
ASN A 197
ILE A   9
ILE A  68
 None
 0.97A 5mioB-3b59A:
undetectable		 5mioB-3b59A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgi PROPANEDIOL
UTILIZATION PROTEIN
PDUU

(Salmonella
enterica) 		PF00936
(BMC) 		5 LEU A  84
ALA A  64
THR A 110
ALA A  23
ILE A 113
 None
 1.06A 5mioB-3cgiA:
undetectable		 5mioB-3cgiA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 258
LEU A 208
ASN A 213
MET A 215
ILE A 218
 None
 1.00A 5mioB-3fxiA:
undetectable		 5mioB-3fxiA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)

(Clostridium
acetobutylicum) 		PF13377
(Peripla_BP_3) 		5 CYH A 248
LEU A 246
ALA A 185
ALA A 232
ILE A 253
 None
 1.01A 5mioB-3g85A:
2.8		 5mioB-3g85A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7p PUTATIVE NITROGEN
REGULATORY PROTEIN
PII

(Streptococcus
mutans) 		PF00543
(P-II) 		5 LEU A  20
ALA A  19
ALA A   6
ILE A   4
ILE A  92
 None
 1.09A 5mioB-3l7pA:
undetectable		 5mioB-3l7pA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n92 ALPHA-AMYLASE, GH57
FAMILY

(Thermococcus
kodakarensis) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 ALA A 185
LEU A 148
ALA A 142
ILE A 179
ILE A 161
 None
 1.00A 5mioB-3n92A:
undetectable		 5mioB-3n92A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouh EGL NINE HOMOLOG 1

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		5 LEU A 271
THR A 257
ALA A 298
LYS A 297
ILE A 386
 None
 1.10A 5mioB-3ouhA:
undetectable		 5mioB-3ouhA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3out GLUTAMATE RACEMASE

(Francisella
tularensis) 		PF01177
(Asp_Glu_race) 		5 LEU A 216
ASN A 219
ALA A  69
ILE A  71
ILE A   7
 None
 1.04A 5mioB-3outA:
undetectable		 5mioB-3outA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN

(Salmonella
enterica) 		PF00291
(PALP) 		5 LEU B 271
ALA B 284
THR B 199
ALA B 191
ILE B 238
 None
 1.00A 5mioB-3pr2B:
2.1		 5mioB-3pr2B:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv2 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 LEU A 115
THR A 209
ILE A 227
LYS A 180
ILE A 207
 None
 1.09A 5mioB-3pv2A:
undetectable		 5mioB-3pv2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 LEU A  40
LEU A  20
ASN A  19
MET A 154
ILE A  62
 None
 0.97A 5mioB-3q3cA:
3.8		 5mioB-3q3cA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5x D-ALANINE--D-ALANINE
LIGASE

(Bacillus
anthracis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 LEU A  58
LEU A  74
ALA A  50
ILE A  38
ILE A  53
 None
 1.02A 5mioB-3r5xA:
undetectable		 5mioB-3r5xA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR1

(Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA) 		5 CYH A 284
LEU A 278
LEU A 193
ASN A 192
ILE A 286
 None
 1.09A 5mioB-3r7wA:
5.3		 5mioB-3r7wA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 525
LEU A 498
LEU A 503
THR A 459
ILE A 486
 None
 1.07A 5mioB-3rg1A:
undetectable		 5mioB-3rg1A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		5 CYH A 317
LEU A 345
ALA A 367
ILE A 314
ILE A 294
 None
None
None
None
ADP  A1250 ( 4.8A)
 1.10A 5mioB-3sfzA:
undetectable		 5mioB-3sfzA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE

(Bartonella
henselae) 		PF00701
(DHDPS) 		5 ALA A 293
LEU A 244
ALA A 260
LYS A 263
ILE A 257
 None
 0.98A 5mioB-3si9A:
undetectable		 5mioB-3si9A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz3 TRYPTOPHANYL-TRNA
SYNTHETASE

(Vibrio cholerae) 		PF00579
(tRNA-synt_1b) 		5 ALA A 226
ASN A 208
MET A 199
ILE A 219
ILE A  18
 None
 1.02A 5mioB-3sz3A:
undetectable		 5mioB-3sz3A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1

(Arabidopsis
thaliana) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		5 CYH A  18
LEU A  19
LEU A 114
LEU A  64
ILE A  84
 None
 1.05A 5mioB-3twkA:
undetectable		 5mioB-3twkA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2h D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 LEU A  22
MET A   0
ALA A 237
ILE A 136
ILE A  84
 None
 0.97A 5mioB-3v2hA:
7.4		 5mioB-3v2hA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		5 LEU A  43
LEU A  20
THR A   8
ALA A   6
ILE A  57
 None
 1.09A 5mioB-3v8vA:
3.5		 5mioB-3v8vA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtc PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00106
(adh_short) 		5 LEU A  73
THR A  11
ALA A   9
ILE A   7
ILE A  33
 None
 0.95A 5mioB-3wtcA:
6.9		 5mioB-3wtcA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 284
LEU A 236
LEU A 262
ASN A 241
ILE A 246
 None
 1.10A 5mioB-3zynA:
undetectable		 5mioB-3zynA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bru ATP-DEPENDENT RNA
HELICASE DHH1

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 223
ALA A  80
ALA A 117
ILE A 119
ILE A 167
 None
 0.97A 5mioB-4bruA:
undetectable		 5mioB-4bruA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5r A49

(Vaccinia virus) 		PF06489
(Orthopox_A49R) 		5 LEU A  65
LEU A 153
ASN A 108
ILE A 146
ILE A 142
 None
 0.95A 5mioB-4d5rA:
undetectable		 5mioB-4d5rA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezb UNCHARACTERIZED
CONSERVED PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 LEU A  56
THR A   3
ALA A   5
ILE A   7
ILE A  62
 None
 1.03A 5mioB-4ezbA:
4.2		 5mioB-4ezbA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knw N-ACYLNEURAMINATE-9-
PHOSPHATASE

(Homo sapiens) 		PF13419
(HAD_2) 		5 CYH A  98
LEU A 101
LEU A  94
ALA A  47
ILE A  34
 None
 0.90A 5mioB-4knwA:
4.2		 5mioB-4knwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 LEU A 125
ALA A 121
ALA A 221
ILE A 224
ILE A 226
 None
 1.06A 5mioB-4lixA:
undetectable		 5mioB-4lixA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mpt PUTATIVE
LEU/ILE/VAL-BINDING
PROTEIN

(Bordetella
pertussis) 		PF13458
(Peripla_BP_6) 		5 LEU A 215
ALA A 237
ALA A 207
ILE A 152
ILE A 151
 None
 1.05A 5mioB-4mptA:
3.2		 5mioB-4mptA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1n SUPERANTIGEN-LIKE
PROTEIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		5 LEU A 142
ASN A 195
MET A 166
ILE A 133
ILE A 189
 None
 1.07A 5mioB-4o1nA:
undetectable		 5mioB-4o1nA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Escherichia
fergusonii) 		PF03480
(DctP) 		5 LEU A 248
LEU A  30
ASN A  31
ILE A 242
ILE A 241
 None
 1.06A 5mioB-4p1eA:
undetectable		 5mioB-4p1eA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3g SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68

(Chaetomium
thermophilum) 		PF16969
(SRP68) 		5 LEU A 116
LEU A 142
ALA A  73
LEU A  70
THR A   9
 None
 1.10A 5mioB-4p3gA:
undetectable		 5mioB-4p3gA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbv NT-3 GROWTH FACTOR
RECEPTOR

(Gallus gallus) 		PF00047
(ig)
PF13855
(LRR_8)
PF16920
(TPKR_C2) 		5 LEU A 146
LEU A  94
ASN A 117
ILE A 132
ILE A 110
 None
 1.10A 5mioB-4pbvA:
undetectable		 5mioB-4pbvA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6j LMO0131 PROTEIN

(Listeria
monocytogenes) 		PF00563
(EAL) 		5 LEU A  60
ALA A  62
ASN A  15
ALA A  11
ILE A   8
 None
 1.02A 5mioB-4q6jA:
undetectable		 5mioB-4q6jA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 LEU A 268
LEU A 273
ASN A 277
THR A 233
ILE A 244
 None
 1.05A 5mioB-4u09A:
undetectable		 5mioB-4u09A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase) 		5 LEU A 431
THR A 534
ALA A 532
ILE A 530
ILE A 519
 None
 0.91A 5mioB-4u3tA:
undetectable		 5mioB-4u3tA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj5 RAB-3A-INTERACTING
PROTEIN

(Homo sapiens) 		no annotation 5 LEU C 333
LEU C 340
LEU C 353
ILE C 403
ILE C 355
 None
 1.01A 5mioB-4uj5C:
undetectable		 5mioB-4uj5C:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF13407
(Peripla_BP_4) 		5 CYH A  99
THR A  52
ALA A  54
ILE A  56
ILE A 111
 None
 1.10A 5mioB-4wzzA:
4.0		 5mioB-4wzzA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Streptobacillus
moniliformis) 		PF13407
(Peripla_BP_4) 		5 ALA A 243
LEU A 241
THR A 267
ALA A 265
ILE A 262
 None
None
None
None
SO4  A 404 (-4.3A)
 1.09A 5mioB-4z0nA:
4.7		 5mioB-4z0nA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2z EXFOLIATIVE TOXIN D2

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 LEU A 266
LEU A 146
ASN A  94
ILE A  86
ILE A 148
 None
 1.05A 5mioB-5c2zA:
undetectable		 5mioB-5c2zA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 5 LEU B 517
LEU B 513
LEU B 329
MET B 307
ALA B 347
 None
 1.03A 5mioB-5cyrB:
undetectable		 5mioB-5cyrB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		5 LEU A 830
LEU A 734
ALA A 806
ILE A 860
ILE A 862
 None
 1.06A 5mioB-5d0fA:
undetectable		 5mioB-5d0fA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 CYH A 338
LEU A 362
LEU A 317
LEU A 344
ILE A 331
 None
 1.04A 5mioB-5gr8A:
undetectable		 5mioB-5gr8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 5 ALA A  40
LEU A  43
ILE A  54
LYS A  31
ILE A 104
 None
 0.97A 5mioB-5gt5A:
undetectable		 5mioB-5gt5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgz N-ALPHA-ACETYLTRANSF
ERASE 60

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		5 LEU A 101
LEU A  99
LEU A 120
ALA A  96
ILE A 135
 ACO  A 301 (-4.3A)
None
None
None
None
 1.06A 5mioB-5hgzA:
undetectable		 5mioB-5hgzA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh0 N-ALPHA-ACETYLTRANSF
ERASE 60

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		5 LEU A 101
LEU A  99
LEU A 120
ALA A  96
ILE A 135
 COA  A 201 (-4.7A)
None
None
None
None
 1.07A 5mioB-5hh0A:
undetectable		 5mioB-5hh0A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jdd TITIN

(Homo sapiens) 		PF07679
(I-set) 		5 LEU A 260
LEU A 184
LEU A 234
MET A 225
ILE A 217
 None
 1.01A 5mioB-5jddA:
undetectable		 5mioB-5jddA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkj ESTERASE E22

(uncultured
bacterium) 		PF00561
(Abhydrolase_1) 		5 LEU A 237
LEU A 244
ALA A 295
ASN A 118
ILE A 219
 None
 1.06A 5mioB-5jkjA:
2.9		 5mioB-5jkjA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA

(Escherichia
coli) 		PF01335
(DED)
PF13416
(SBP_bac_8) 		5 LEU A 151
LEU A 134
THR A 257
ILE A 144
LYS A 139
 None
 0.99A 5mioB-5jqeA:
undetectable		 5mioB-5jqeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtw COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 LEU B1141
THR B1203
ALA B1199
ILE B1195
ILE B1147
 None
 1.07A 5mioB-5jtwB:
undetectable		 5mioB-5jtwB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5z PARA

(Sulfolobus sp.
NOB8H2) 		PF13614
(AAA_31) 		5 LEU A  36
ALA A   3
ALA A 156
ILE A 140
ILE A 124
 None
 1.05A 5mioB-5k5zA:
3.8		 5mioB-5k5zA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis) 		PF00291
(PALP) 		5 LEU B 270
ALA B 283
THR B 198
ALA B 190
ILE B 237
 None
 1.06A 5mioB-5kzmB:
2.5		 5mioB-5kzmB:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 253
MET A 257
THR A 311
ALA A 313
ILE A 367
 None
 1.04A 5mioB-5mjsA:
54.6		 5mioB-5mjsA:
58.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 ALA B 250
ASN B 258
MET B 259
THR B 314
ILE B 378
 None
 0.82A 5mioB-5n5nB:
55.3		 5mioB-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 LEU B 255
ASN B 258
MET B 259
THR B 314
ILE B 378
 None
 0.90A 5mioB-5n5nB:
55.3		 5mioB-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 LEU B 255
MET B 259
THR B 314
ALA B 316
ILE B 378
 None
 1.01A 5mioB-5n5nB:
55.3		 5mioB-5n5nB:
97.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0v IRON SULFUR CLUSTER
ASSEMBLY PROTEIN 1,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01491
(Frataxin_Cyay) 		5 ALA a 150
LEU a  75
MET a  73
ALA a 143
ILE a 121
 None
 1.04A 5mioB-5t0va:
undetectable		 5mioB-5t0va:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bacillus
anthracis) 		PF00496
(SBP_bac_5) 		5 LEU A 275
LEU A 259
ASN A 258
ILE A 248
ILE A 245
 None
 1.01A 5mioB-5u4oA:
undetectable		 5mioB-5u4oA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6t PLEXIN-D1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 LEU A1714
ALA A1520
LEU A1518
THR A1788
ILE A1798
 None
 1.10A 5mioB-5v6tA:
undetectable		 5mioB-5v6tA:
22.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 LEU B 253
ASN B 256
THR B 312
ALA B 314
ILE B 368
 None
 0.80A 5mioB-5w3jB:
54.7		 5mioB-5w3jB:
75.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7z DNA POLYMERASE III
SUBUNIT BETA

(Rickettsia
conorii) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 LEU A 195
ALA A 200
THR A 234
ILE A 219
ILE A 217
 None
 1.04A 5mioB-5w7zA:
undetectable		 5mioB-5w7zA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6h FLAGELLAR BRAKE
PROTEIN YCGR

(Escherichia
coli) 		no annotation 5 LEU A 108
LEU A  23
THR A  77
ALA A  75
ILE A  73
 None
 0.99A 5mioB-5y6hA:
undetectable		 5mioB-5y6hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9k DARP14 - SUBUNIT A
WITH DARPIN

(synthetic
construct) 		no annotation 5 LEU A  87
ALA A 148
LEU A 146
ILE A  79
ILE A  66
 None
 1.06A 5mioB-6c9kA:
undetectable		 5mioB-6c9kA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 10
N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 5 LEU A 541
LEU B  11
ASN B  13
MET B  14
ALA B   6
 None
 0.92A 5mioB-6c9mA:
undetectable		 5mioB-6c9mA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxd PEPTIDASE B

(Yersinia pestis) 		no annotation 5 LEU A 244
THR A 305
ALA A 303
ILE A 301
ILE A 396
 None
 0.94A 5mioB-6cxdA:
undetectable		 5mioB-6cxdA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi) 		no annotation 5 LEU A 195
ALA A 200
THR A 234
ILE A 219
ILE A 217
 None
 1.03A 5mioB-6d46A:
undetectable		 5mioB-6d46A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dg4 ULP1-LIKE SUMO
PROTEASE

(Chaetomium
thermophilum) 		no annotation 5 ALA A 167
THR A 139
ALA A 141
ILE A 143
ILE A 130
 None
 0.81A 5mioB-6dg4A:
undetectable		 5mioB-6dg4A:
10.79