SIMILAR PATTERNS OF AMINO ACIDS FOR 5MIG_A_CUA601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 106
HIS A 450
HIS A 506
 CU  A 555 (-3.3A)
CU  A 555 ( 3.2A)
CU  A 555 (-3.1A)
 0.12A 5migA-1asoA:
40.5		 5migA-1asoA:
29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 HIS A 109
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.24A 5migA-1bt2A:
undetectable		 5migA-1bt2A:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 400
HIS A 452
 CU  A1501 (-3.4A)
CU  A1501 ( 3.2A)
CU  A1501 (-3.3A)
 0.11A 5migA-1gycA:
63.6		 5migA-1gycA:
65.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 401
HIS A 451
 CU  A 702 (-3.2A)
CU  A 702 (-3.2A)
CU  A 702 (-3.2A)
 0.13A 5migA-1hfuA:
60.6		 5migA-1hfuA:
56.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Escherichia
coli) 		PF00293
(NUDIX) 		3 HIS A  25
HIS A  32
HIS A  69
 MN  A1001 (-3.4A)
MN  A1001 (-3.4A)
MN  A1001 (-3.1A)
 0.50A 5migA-1i9aA:
undetectable		 5migA-1i9aA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A2562
HIS A2571
HIS A2543
 CUO  A 888 (-3.4A)
CUO  A 888 (-3.3A)
CUO  A 888 (-3.4A)
 0.31A 5migA-1js8A:
undetectable		 5migA-1js8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA

(Treponema
pallidum) 		PF01297
(ZnuA) 		3 HIS A 133
HIS A  68
HIS A 199
 None
 0.49A 5migA-1k0fA:
undetectable		 5migA-1k0fA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 163
HIS A 980
HIS A1020
 CU  A1050 (-3.3A)
CU  A1050 (-3.0A)
CU  A1050 (-3.2A)
 0.59A 5migA-1kcwA:
17.9		 5migA-1kcwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A1022
HIS A 103
HIS A 161
 CU  A1051 (-3.2A)
CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
 0.28A 5migA-1kcwA:
17.9		 5migA-1kcwA:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 400
HIS A 452
 CU  A 501 (-3.5A)
CU  A 501 ( 3.3A)
CU  A 501 (-3.4A)
 0.13A 5migA-1kyaA:
63.1		 5migA-1kyaA:
66.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A  61
HIS A  70
HIS A  41
 CU  A5001 (-3.6A)
CU  A5001 ( 3.1A)
CU  A5001 (-2.9A)
 0.39A 5migA-1lnlA:
undetectable		 5migA-1lnlA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toa PROTEIN (PERIPLASMIC
BINDING PROTEIN
TROA)

(Treponema
pallidum) 		PF01297
(ZnuA) 		3 HIS A 133
HIS A  68
HIS A 199
 ZN  A 501 ( 3.5A)
ZN  A 501 ( 3.4A)
ZN  A 501 ( 3.4A)
 0.44A 5migA-1toaA:
undetectable		 5migA-1toaA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ton TONIN

(Rattus rattus) 		PF00089
(Trypsin) 		3 HIS A  57
HIS A  97
HIS A  99
 ZN  A 247 (-3.2A)
ZN  A 247 (-3.2A)
ZN  A 247 (-3.2A)
 0.58A 5migA-1tonA:
undetectable		 5migA-1tonA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uio ADENOSINE DEAMINASE

(Mus musculus) 		PF00962
(A_deaminase) 		3 HIS A 214
HIS A  15
HIS A  17
 ZN  A 400 ( 3.3A)
ZN  A 400 (-3.4A)
HPR  A 353 ( 3.1A)
 0.55A 5migA-1uioA:
undetectable		 5migA-1uioA:
18.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 401
HIS A 451
 CU  A1501 (-3.3A)
CU  A1501 ( 3.2A)
CU  A1501 (-2.9A)
 0.24A 5migA-1v10A:
61.4		 5migA-1v10A:
57.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		3 HIS A  54
HIS A  63
HIS A  38
 CU  A 400 ( 3.3A)
CU  A 400 ( 3.5A)
CU  A 400 ( 3.3A)
 0.29A 5migA-1wx4A:
undetectable		 5migA-1wx4A:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 128
HIS A 418
HIS A 483
 CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.18A 5migA-1zpuA:
44.1		 5migA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amx ADENOSINE DEAMINASE

(Plasmodium
yoelii) 		PF00962
(A_deaminase) 		3 HIS A 239
HIS A  55
HIS A  57
 CO  A1000 (-3.4A)
CO  A1000 (-3.3A)
CO  A1000 (-3.2A)
 0.49A 5migA-2amxA:
undetectable		 5migA-2amxA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		3 HIS A 249
HIS A  80
HIS A  82
 ZN  A1601 (-3.4A)
ZN  A1601 (-3.4A)
ZN  A1601 (-3.4A)
 0.46A 5migA-2bb0A:
undetectable		 5migA-2bb0A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE

(Thermus
thermophilus) 		PF00596
(Aldolase_II) 		3 HIS A  88
HIS A  90
HIS A 151
 None
 0.55A 5migA-2fk5A:
undetectable		 5migA-2fk5A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 143
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.25A 5migA-2fqdA:
32.6		 5migA-2fqdA:
23.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 400
HIS A 452
 CU  A 602 (-3.2A)
CU  A 602 ( 3.2A)
CU  A 602 (-3.1A)
 0.14A 5migA-2hzhA:
63.1		 5migA-2hzhA:
62.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		3 HIS A  99
HIS A  97
HIS A 238
 ZN  A 500 (-3.2A)
ZN  A 500 (-3.3A)
ZN  A 500 (-3.2A)
 0.59A 5migA-2imrA:
undetectable		 5migA-2imrA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o03 PROBABLE ZINC UPTAKE
REGULATION PROTEIN
FURB

(Mycobacterium
tuberculosis) 		PF01475
(FUR) 		3 HIS A  80
HIS A  82
HIS A 118
 ZN  A 203 (-3.3A)
ZN  A 203 (-3.1A)
ZN  A 203 (-3.3A)
 0.59A 5migA-2o03A:
undetectable		 5migA-2o03A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o03 PROBABLE ZINC UPTAKE
REGULATION PROTEIN
FURB

(Mycobacterium
tuberculosis) 		PF01475
(FUR) 		3 HIS A 118
HIS A  82
HIS A  80
 ZN  A 203 (-3.3A)
ZN  A 203 (-3.1A)
ZN  A 203 (-3.3A)
 0.46A 5migA-2o03A:
undetectable		 5migA-2o03A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		3 HIS A 234
HIS A  79
HIS A  81
 GUN  A 600 ( 2.8A)
ZN  A 500 ( 3.3A)
ZN  A 500 ( 3.3A)
 0.49A 5migA-2oodA:
undetectable		 5migA-2oodA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 HIS A 108
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.18A 5migA-2p3xA:
undetectable		 5migA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puz IMIDAZOLONEPROPIONAS
E

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		3 HIS A 256
HIS A  86
HIS A  88
 FE  A 500 (-3.6A)
FE  A 500 (-3.3A)
FE  A 500 (-3.3A)
 0.47A 5migA-2puzA:
undetectable		 5migA-2puzA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q09 IMIDAZOLONEPROPIONAS
E

(unidentified) 		PF01979
(Amidohydro_1) 		3 HIS A 242
HIS A  72
HIS A  74
 FE  A 500 ( 3.5A)
FE  A 500 (-3.4A)
FE  A 500 (-3.2A)
 0.50A 5migA-2q09A:
undetectable		 5migA-2q09A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		3 HIS A 217
HIS A  60
HIS A  62
 ZN  A 501 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.47A 5migA-2qt3A:
undetectable		 5migA-2qt3A:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 399
HIS A 451
 CU  A 501 ( 3.2A)
CU  A 501 ( 3.2A)
CU  A 501 (-3.2A)
 0.11A 5migA-2qt6A:
63.7		 5migA-2qt6A:
64.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 400
HIS A 450
 CU  A 502 (-3.2A)
CU  A 502 (-3.2A)
CU  A 502 ( 3.3A)
 0.13A 5migA-2xybA:
63.7		 5migA-2xybA:
63.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		3 HIS A  85
HIS A  94
HIS A  61
 CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
 0.29A 5migA-2y9xA:
undetectable		 5migA-2y9xA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 136
HIS A 403
HIS A 456
 CU  A 701 (-3.2A)
CU  A 701 ( 3.1A)
CU  A 701 (-3.3A)
 0.31A 5migA-3abgA:
30.9		 5migA-3abgA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 134
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.19A 5migA-3aw5A:
13.1		 5migA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx3 LIPOPROTEIN

(Streptococcus
pneumoniae) 		PF01297
(ZnuA) 		3 HIS A 147
HIS A  71
HIS A 211
 ZN  A 314 (-3.2A)
ZN  A 314 (-3.1A)
ZN  A 314 (-3.3A)
 0.39A 5migA-3cx3A:
undetectable		 5migA-3cx3A:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 140
HIS A 436
HIS A 502
 CU  A 602 ( 3.3A)
CU  A 602 (-3.2A)
CU  A 602 ( 3.2A)
 0.20A 5migA-3dkhA:
42.7		 5migA-3dkhA:
30.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax) 		PF00962
(A_deaminase) 		3 HIS A 225
HIS A  42
HIS A  44
 ZN  A 371 ( 3.4A)
ZN  A 371 (-3.3A)
MCF  A 372 ( 3.3A)
 0.52A 5migA-3ewdA:
undetectable		 5migA-3ewdA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN

(Bos taurus) 		PF03055
(RPE65) 		3 HIS A 527
HIS A 180
HIS A 313
 FE2  A 534 (-3.3A)
FE2  A 534 (-3.4A)
FE2  A 534 (-3.4A)
 0.54A 5migA-3fsnA:
undetectable		 5migA-3fsnA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		3 HIS A 214
HIS A  61
HIS A  63
 FE  A 502 (-3.6A)
FE  A 502 (-3.1A)
FE  A 502 (-3.1A)
 0.49A 5migA-3g77A:
undetectable		 5migA-3g77A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 203
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.20A 5migA-3gyrA:
26.2		 5migA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht1 REMF PROTEIN

(Streptomyces
resistomycificus) 		PF07883
(Cupin_2) 		3 HIS A  55
HIS A  95
HIS A  59
 NI  A 151 (-3.3A)
NI  A 151 (-3.3A)
NI  A 151 (-3.3A)
 0.52A 5migA-3ht1A:
undetectable		 5migA-3ht1A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibm CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN

(Halorhodospira
halophila) 		PF07883
(Cupin_2) 		3 HIS A  72
HIS A 110
HIS A  76
 ZN  A 200 (-3.3A)
ZN  A 200 (-3.3A)
ZN  A 200 (-3.3A)
 0.44A 5migA-3ibmA:
undetectable		 5migA-3ibmA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzv UNCHARACTERIZED
PROTEIN RRU_A2000

(Rhodospirillum
rubrum) 		PF07883
(Cupin_2) 		3 HIS A  69
HIS A 107
HIS A  73
 MN  A 200 (-3.3A)
MN  A 200 (-3.6A)
MN  A 200 (-3.6A)
 0.48A 5migA-3jzvA:
undetectable		 5migA-3jzvA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgz CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Rhodopseudomonas
palustris) 		PF07883
(Cupin_2) 		3 HIS A  78
HIS A 116
HIS A  82
 MN  A   1 (-3.5A)
MN  A   1 (-3.5A)
MN  A   1 (-3.4A)
 0.42A 5migA-3kgzA:
undetectable		 5migA-3kgzA:
14.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 405
HIS A 455
 CU  A 603 (-3.2A)
CU  A 603 ( 3.0A)
CU  A 603 (-3.1A)
 0.24A 5migA-3kw7A:
62.6		 5migA-3kw7A:
65.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgg ADENOSINE DEAMINASE
CECR1

(Homo sapiens) 		PF00962
(A_deaminase)
PF08451
(A_deaminase_N) 		3 HIS A 330
HIS A  86
HIS A  88
 ZN  A 512 ( 3.5A)
ZN  A 512 (-3.4A)
CFE  A 513 ( 3.3A)
 0.49A 5migA-3lggA:
undetectable		 5migA-3lggA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Streptococcus
suis) 		PF01297
(ZnuA) 		3 HIS A 131
HIS A  68
HIS A 197
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.6A)
ZN  A 401 (-3.4A)
 0.47A 5migA-3mfqA:
undetectable		 5migA-3mfqA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwm PUTATIVE METAL
UPTAKE REGULATION
PROTEIN

(Streptomyces
coelicolor) 		PF01475
(FUR) 		3 HIS A  84
HIS A  86
HIS A 122
 ZN  A 142 (-3.1A)
ZN  A 142 (-3.2A)
ZN  A 142 (-3.2A)
 0.55A 5migA-3mwmA:
undetectable		 5migA-3mwmA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwm PUTATIVE METAL
UPTAKE REGULATION
PROTEIN

(Streptomyces
coelicolor) 		PF01475
(FUR) 		3 HIS A 122
HIS A  86
HIS A  84
 ZN  A 142 (-3.2A)
ZN  A 142 (-3.2A)
ZN  A 142 (-3.1A)
 0.45A 5migA-3mwmA:
undetectable		 5migA-3mwmA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pao ADENOSINE DEAMINASE

(Pseudomonas
aeruginosa) 		PF00962
(A_deaminase) 		3 HIS A 196
HIS A  16
HIS A  18
 ZN  A 327 ( 3.5A)
ZN  A 327 (-3.4A)
ADE  A 328 ( 3.0A)
 0.58A 5migA-3paoA:
undetectable		 5migA-3paoA:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 141
HIS A 437
HIS A 503
 CU  A 602 ( 3.3A)
CU  A 602 (-3.3A)
CU  A 602 ( 3.3A)
 0.18A 5migA-3ppsA:
41.9		 5migA-3ppsA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 400
HIS A 452
 CU  A1500 (-3.2A)
CU  A1500 ( 3.2A)
CU  A1500 (-3.1A)
 0.11A 5migA-3pxlA:
63.9		 5migA-3pxlA:
65.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rys ADENOSINE DEAMINASE
1

(Paenarthrobacter
aurescens) 		PF00962
(A_deaminase) 		3 HIS A 199
HIS A  19
HIS A  21
 ZN  A 344 ( 3.4A)
ZN  A 344 (-3.5A)
ADE  A 345 ( 3.2A)
 0.59A 5migA-3rysA:
undetectable		 5migA-3rysA:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 112
HIS A 402
HIS A 452
 CU  A 503 (-3.4A)
CU  A 503 ( 3.2A)
CU  A 503 ( 3.3A)
 0.11A 5migA-3t6wA:
68.2		 5migA-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		3 HIS A 206
HIS A  61
HIS A  63
 FE  A 429 (-3.3A)
FE  A 429 (-3.2A)
FE  A 429 (-3.2A)
 0.57A 5migA-3v7pA:
undetectable		 5migA-3v7pA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 133
HIS A 431
HIS A 488
 CU  A 602 (-3.3A)
CU  A 602 (-3.1A)
CU  A 602 (-3.1A)
 0.27A 5migA-3v9eA:
44.2		 5migA-3v9eA:
33.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		3 HIS A  94
HIS A 103
HIS A  67
 None
 0.57A 5migA-3w6qA:
undetectable		 5migA-3w6qA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxw ADIPONECTIN RECEPTOR
PROTEIN 2

(Homo sapiens) 		PF03006
(HlyIII) 		3 HIS A 202
HIS A 352
HIS A 348
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
 0.51A 5migA-3wxwA:
undetectable		 5migA-3wxwA:
19.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 132
HIS A 422
HIS A 474
 CU  A 616 (-3.2A)
CU  A 616 ( 3.2A)
CU  A 616 (-3.2A)
 0.06A 5migA-3x1bA:
63.2		 5migA-3x1bA:
62.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 182
HIS A 444
HIS A 494
 CU  A 603 ( 2.8A)
CU  A 603 (-3.1A)
CU  A 603 ( 3.1A)
 0.35A 5migA-3zx1A:
14.3		 5migA-3zx1A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 155
HIS A 424
HIS A 491
 CU  A 603 ( 3.2A)
CU  A 603 (-3.2A)
CU  A 603 ( 3.1A)
 0.15A 5migA-4akoA:
31.9		 5migA-4akoA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A  60
HIS A  69
HIS A  42
 CUO  A9001 (-3.1A)
CUO  A9001 (-3.1A)
CUO  A9001 (-3.4A)
 0.33A 5migA-4bedA:
undetectable		 5migA-4bedA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A 482
HIS A 491
HIS A 462
 CUO  A9002 (-3.4A)
CUO  A9002 (-3.4A)
CUO  A9002 (-3.2A)
 0.36A 5migA-4bedA:
undetectable		 5migA-4bedA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A 896
HIS A 905
HIS A 876
 CUO  A9003 (-3.4A)
CUO  A9003 (-3.5A)
CUO  A9003 (-3.3A)
 0.39A 5migA-4bedA:
undetectable		 5migA-4bedA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A1311
HIS A1320
HIS A1293
 CUO  A9004 (-3.4A)
CUO  A9004 (-3.5A)
CUO  A9004 (-3.2A)
 0.31A 5migA-4bedA:
undetectable		 5migA-4bedA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS B1725
HIS B1734
HIS B1705
 CUO  B9005 (-3.1A)
CUO  B9005 (-3.4A)
CUO  B9005 (-3.2A)
 0.36A 5migA-4bedB:
3.6		 5migA-4bedB:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS B2141
HIS B2150
HIS B2122
 CUO  B9006 (-3.1A)
CUO  B9006 (-3.3A)
CUO  B9006 (-3.2A)
 0.42A 5migA-4bedB:
3.6		 5migA-4bedB:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS B2561
HIS B2570
HIS B2542
 CUO  B9007 (-3.3A)
CUO  B9007 (-3.3A)
CUO  B9007 (-3.3A)
 0.36A 5migA-4bedB:
3.6		 5migA-4bedB:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxw ADENOSINE DEAMINASE

(Burkholderia
ambifaria) 		PF00962
(A_deaminase) 		3 HIS A 215
HIS A  34
HIS A  36
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
 0.57A 5migA-4gxwA:
undetectable		 5migA-4gxwA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0f LAMININ-BINDING
SURFACE PROTEIN

(Streptococcus
agalactiae) 		PF01297
(ZnuA) 		3 HIS A 142
HIS A  66
HIS A 206
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.1A)
ZN  A 401 (-3.4A)
 0.45A 5migA-4h0fA:
undetectable		 5migA-4h0fA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		3 HIS A 110
HIS A 119
HIS A 102
 CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 (-3.2A)
 0.39A 5migA-4j3qA:
undetectable		 5migA-4j3qA:
22.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 399
HIS A 449
 CU  A 501 (-3.2A)
CU  A 501 ( 3.2A)
CU  A 501 (-3.1A)
 0.10A 5migA-4jhvA:
63.1		 5migA-4jhvA:
62.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		3 HIS B  82
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.30A 5migA-4ouaB:
undetectable		 5migA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		3 HIS A  82
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.30A 5migA-4ouaA:
undetectable		 5migA-4ouaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		3 HIS A 209
HIS A  56
HIS A  58
 FE2  A 502 ( 3.4A)
FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
 0.42A 5migA-4r85A:
undetectable		 5migA-4r85A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		3 HIS A 390
HIS A 408
HIS A 406
 NI  A 502 ( 3.4A)
NI  A 502 (-3.2A)
NI  A 502 ( 3.3A)
 0.29A 5migA-4rnzA:
undetectable		 5migA-4rnzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		3 HIS A 243
HIS A  66
HIS A  68
 FE  A 481 (-4.1A)
FE  A 481 (-3.9A)
FE  A 481 (-3.9A)
 0.56A 5migA-4v1yA:
undetectable		 5migA-4v1yA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		3 HIS A 156
HIS A 298
HIS A 265
 ZN  A 402 (-3.4A)
ZN  A 402 (-3.4A)
ZN  A 402 (-3.4A)
 0.58A 5migA-4ymkA:
undetectable		 5migA-4ymkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0z AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 HIS A 116
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 700 (-3.1A)
 0.17A 5migA-4z0zA:
undetectable		 5migA-4z0zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		3 HIS A 116
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
 0.17A 5migA-4z11A:
undetectable		 5migA-4z11A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		3 HIS A 348
HIS A 272
HIS A 249
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.4A)
ZN  A 402 (-3.2A)
 0.54A 5migA-4zr0A:
undetectable		 5migA-4zr0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 3 HIS A 160
HIS A 302
HIS A 269
 ZN  A 402 (-3.2A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
 0.53A 5migA-4zyoA:
undetectable		 5migA-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq6 METAL-BINDING
PROTEIN ZINT

(Escherichia
coli) 		PF09223
(ZinT) 		3 HIS A   1
HIS A 193
HIS A   6
 ZN  A1194 (-3.1A)
ZN  A1194 (-3.1A)
ZN  A1194 (-3.2A)
 0.59A 5migA-5aq6A:
undetectable		 5migA-5aq6A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq6 METAL-BINDING
PROTEIN ZINT

(Escherichia
coli) 		PF09223
(ZinT) 		3 HIS A   6
HIS A 193
HIS A   1
 ZN  A1194 (-3.2A)
ZN  A1194 (-3.1A)
ZN  A1194 (-3.1A)
 0.46A 5migA-5aq6A:
undetectable		 5migA-5aq6A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce9 POLYPHENOL OXIDASE

(Juglans regia) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 HIS A 108
HIS A 117
HIS A  87
 CU  A 402 ( 3.2A)
CU  A 402 ( 3.2A)
CU  A 402 ( 3.2A)
 0.19A 5migA-5ce9A:
undetectable		 5migA-5ce9A:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 400
HIS A 450
 CU  A 507 ( 3.3A)
CU  A 507 ( 3.1A)
CU  A 507 (-3.2A)
 0.23A 5migA-5ehfA:
63.9		 5migA-5ehfA:
64.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 137
HIS A 398
HIS A 444
 CU  A1463 (-3.3A)
CU  A1463 (-2.9A)
CU  A1463 (-3.0A)
 0.45A 5migA-5g3fA:
35.3		 5migA-5g3fA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		3 HIS A  60
HIS A  69
HIS A  42
 ZN  A 301 ( 3.2A)
ZN  A 302 ( 4.9A)
ZN  A 301 ( 3.2A)
 0.40A 5migA-5i3aA:
undetectable		 5migA-5i3aA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kja APOCAROTENOID-15,15'
-OXYGENASE

(Synechocystis
sp. PCC 6803) 		PF03055
(RPE65) 		3 HIS A 484
HIS A 183
HIS A 304
 FE2  A 502 (-4.0A)
FE2  A 502 (-4.0A)
FE2  A 502 (-3.8A)
 0.55A 5migA-5kjaA:
undetectable		 5migA-5kjaA:
24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 154
HIS A 453
HIS A 515
 CU  A 602 ( 3.4A)
CU  A 602 (-3.1A)
CU  A 602 ( 3.2A)
 0.12A 5migA-5lm8A:
43.7		 5migA-5lm8A:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 517
HIS A 110
HIS A 152
 CU  A 601 ( 3.5A)
CU  A 601 (-2.9A)
CU  A 601 ( 3.2A)
 0.59A 5migA-5lm8A:
43.7		 5migA-5lm8A:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		3 HIS A 215
HIS A 224
HIS A 192
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
 0.36A 5migA-5m8tA:
undetectable		 5migA-5m8tA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 112
HIS A 402
HIS A 452
 CU  A 501 (-3.1A)
CU  A 501 (-3.2A)
CU  A 501 ( 3.0A)
 0.12A 5migA-5mewA:
70.6		 5migA-5mewA:
99.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 HIS A 162
HIS A 974
HIS A1014
 CU  A1101 (-3.3A)
CU  A1101 ( 3.2A)
CU  A1101 (-3.2A)
 0.33A 5migA-5n4lA:
11.8		 5migA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 HIS A1016
HIS A 103
HIS A 160
 CU  A1104 (-3.1A)
CU  A1104 ( 3.5A)
CU  A1104 (-3.6A)
 0.47A 5migA-5n4lA:
11.8		 5migA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 3 HIS A 110
HIS A 119
HIS A 102
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
 0.38A 5migA-5or4A:
undetectable		 5migA-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8z CAROTENOID OXYGENASE
1

(Neurospora
crassa) 		PF03055
(RPE65) 		3 HIS A 510
HIS A 197
HIS A 313
 FE2  A 601 (-3.3A)
FE2  A 601 (-3.3A)
FE2  A 601 ( 3.4A)
 0.54A 5migA-5u8zA:
undetectable		 5migA-5u8zA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN

(Paracoccus
denitrificans) 		PF01297
(ZnuA) 		3 HIS A 138
HIS A  61
HIS A 204
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
 0.53A 5migA-5w57A:
undetectable		 5migA-5w57A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 3 HIS A 133
HIS A 439
HIS A 489
 EDO  A 602 (-4.1A)
EDO  A 602 (-3.8A)
None
 0.53A 5migA-6evgA:
33.8		 5migA-6evgA:
undetectable